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Articles 2881 - 2910 of 4871
Full-Text Articles in Medicine and Health Sciences
Early Surgical Results Of A 23-Gauge Trocar Combined With A One-Directional Valve System In Primary And Secondary Pars Plana Vitrectomy, Ayşe Gül Altintaş, Hasan Basri̇ Ari̇foğlu, Şükrü Gülteki̇n Köklü, Kenan Sönmez
Early Surgical Results Of A 23-Gauge Trocar Combined With A One-Directional Valve System In Primary And Secondary Pars Plana Vitrectomy, Ayşe Gül Altintaş, Hasan Basri̇ Ari̇foğlu, Şükrü Gülteki̇n Köklü, Kenan Sönmez
Turkish Journal of Medical Sciences
To elucidate the early surgical advantages of a 23-gauge trocar combined with a one-directional valve system in transconjunctival pars plana vitrectomies. Materials and methods: Early surgical results of 432 eyes of 432 patients (190 female and 242 male) who underwent 23-gauge (23G) transconjunctival sutureless vitrectomies (TSV) were evaluated. Sixty-three patients out of 432 underwent a second operation, 29 of them underwent silicone oil extraction, and 34 had phacoemulsification surgery with the help of vitreous infusion. If any sign of leakage was observed after the withdrawal of the cannulae, a suture was applied at the conjunctiva-scleral opening site. Results: A total …
Calcifying Fibrous Pseudotumor Of Lungs, Serdar Özkan, Funda Demi̇rağ, Erdal Yekeler, Nuretti̇n Karaoğlanoğlu
Calcifying Fibrous Pseudotumor Of Lungs, Serdar Özkan, Funda Demi̇rağ, Erdal Yekeler, Nuretti̇n Karaoğlanoğlu
Turkish Journal of Medical Sciences
Calcified fibrous pseudotumors can generally be detected as solitary masses in various regions of the body, and were first described in 1988. In this case report, we discuss an adult patient whose tumor was localized in the lung, which has not been reported in the literature before.
Assessment Of Left Ventricular Function By Strain–Strain Rate Echocardiography In Patients With Celiac Disease, Cenk Sari, Ayli̇n Demi̇rezer Bolat, Fatma Ebru Akin, Ni̇hal Akar Bayram, Sevi̇l Özer Sari, Serdal Baştuğ, Emi̇ne Bi̇len, Hüseyi̇n Ayhan, Telat Keleş, Tahi̇r Durmaz, Osman Ersoy, Engi̇n Bozkurt
Assessment Of Left Ventricular Function By Strain–Strain Rate Echocardiography In Patients With Celiac Disease, Cenk Sari, Ayli̇n Demi̇rezer Bolat, Fatma Ebru Akin, Ni̇hal Akar Bayram, Sevi̇l Özer Sari, Serdal Baştuğ, Emi̇ne Bi̇len, Hüseyi̇n Ayhan, Telat Keleş, Tahi̇r Durmaz, Osman Ersoy, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Celiac is predominantly a disease of the small intestine characterized by chronic malabsorption in genetically susceptible individuals who ingest grains containing gluten, such as wheat, barley, and rye. In the present study, we evaluate left ventricular function in patients with celiac disease by using strain and strain rate echocardiography imaging. Materials and methods: Twenty celiac patients and 20 healthy controls were included in this study. Left ventricle systolic and diastolic functions were evaluated with standard 2-dimension, M-mode, conventional Doppler echocardiography. Strain and strain rate parameters were obtained for 8 segments of the left ventricle. Results: There were no significant differences …
Relationship Of Admission Neutrophil-To-Lymphocyte Ratio With In-Hospital Mortality In Patients With Acute Type-I Aortic Dissection, Gökhan Lafçi, Ömer Faruk Çi̇çek, Haci Alper Uzun, Adnan Yalçinkaya, Adem İlkay Di̇ken, Osman Turak, Kumral Çağli, İrfan Taşoğlu, Hi̇kmet Selçuk Gedi̇k, Kemal Korkmaz, Orhan Eren Günertem, Keri̇m Çağli
Relationship Of Admission Neutrophil-To-Lymphocyte Ratio With In-Hospital Mortality In Patients With Acute Type-I Aortic Dissection, Gökhan Lafçi, Ömer Faruk Çi̇çek, Haci Alper Uzun, Adnan Yalçinkaya, Adem İlkay Di̇ken, Osman Turak, Kumral Çağli, İrfan Taşoğlu, Hi̇kmet Selçuk Gedi̇k, Kemal Korkmaz, Orhan Eren Günertem, Keri̇m Çağli
Turkish Journal of Medical Sciences
Acute aortic dissection is a life-threatening cardiovascular emergency. Neutrophil-to-lymphocyte ratio is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. The aim of the present study was to evaluate the relationship between admission neutrophil-to-lymphocyte ratio and in-hospital mortality in acute type I aortic dissection. Materials and methods: We retrospectively evaluated 123 consecutive patients who had undergone emergent surgery for acute type I aortic dissection. Patients were divided into 2 groups as patients dying in the hospital (Group 1) and those discharged alive (Group 2). All parameters, including neutrophil-to-lymphocyte ratio, were compared …
Evaluation Of Hepatocellular Carcinoma With Computed Tomography Perfusion Imaging, Ümmügülsüm Bayraktutan, Abdulmeci̇t Kantarci, Hayri̇ Oğul, Yeşi̇m Kizrak, Ömer Özyi̇ği̇t, Zeyneb Yüceler, Berhan Genç, Bünyami̇ Özoğul
Evaluation Of Hepatocellular Carcinoma With Computed Tomography Perfusion Imaging, Ümmügülsüm Bayraktutan, Abdulmeci̇t Kantarci, Hayri̇ Oğul, Yeşi̇m Kizrak, Ömer Özyi̇ği̇t, Zeyneb Yüceler, Berhan Genç, Bünyami̇ Özoğul
Turkish Journal of Medical Sciences
To evaluate the role of computed tomography (CT) perfusion imaging in patients with hepatocellular carcinoma (HCC). Materials and methods: Seventeen patients (9 men, 8 women) with newly diagnosed HCC, proven by biopsy, were evaluated with 256-slice helical CT. Perfusion parameters of blood flow (BF), blood volume (BV), arterial perfusion (AP), portal perfusion (PP), and hepatic perfusion index (HPI) were calculated in the normal liver parenchyma and HCC samples. Results: A total of 21 histologically proven HCC lesions were evaluated from CT perfusion images. BF, BV, AP, and HPI values were shown to be significantly higher (P < 0.05) in the HCC lesions than in the normal liver parenchyma. Conversely, PP values were found to be significantly lower (P < 0.05) in HCC relative to liver parenchyma. Conclusion: CT perfusion imaging has the ability to evaluate tumor assessment, characterization, and neoangiogenesis in HCC.
A Comparison Of The Generation Of Free Radicals In Saliva Of Active And Passive Smokers, Murat Demi̇rtaş, Ünal Şenel, Sevda Yüksel, Mustafa Yüksel
A Comparison Of The Generation Of Free Radicals In Saliva Of Active And Passive Smokers, Murat Demi̇rtaş, Ünal Şenel, Sevda Yüksel, Mustafa Yüksel
Turkish Journal of Medical Sciences
To reveal any correlation between cigarette smoke and malondialdehyde (MDA) values in the saliva fluid of subjects who are active smokers or nonsmoking subjects who are exposed to cigarette smoke in their environments. Materials and methods: Saliva samples were taken from 3 groups: a control group (group 1), a group inhaling smoke passively (group 2), and a test group (group 3) smoking 20 cigarettes per day; each group consisted of 20 members, giving a total sample of 60 people, aged 20 to 45 years. MDA, which is an indicator of lipid peroxidation, was measured via the colorimetric method. Results: Salivary …
A Comparison Of The Effects Of Hyperbaric And Isobaric Bupivacaine Spinal Anesthesia On Hemodynamics And Heart Rate Variability, Mehmet Toptaş, Si̇nan Uzman, İlke İşi̇temi̇z, Tümay Uludağ Yanaral, İbrahi̇m Akkoç, Gülşen Bi̇can
A Comparison Of The Effects Of Hyperbaric And Isobaric Bupivacaine Spinal Anesthesia On Hemodynamics And Heart Rate Variability, Mehmet Toptaş, Si̇nan Uzman, İlke İşi̇temi̇z, Tümay Uludağ Yanaral, İbrahi̇m Akkoç, Gülşen Bi̇can
Turkish Journal of Medical Sciences
To compare the effects of hyperbaric and isobaric bupivacaine spinal anesthesia on hemodynamics and heart rate variability (HRV) in nonobstetric surgery. Materials and methods: Sixty patients were randomly allocated to 2 groups. Group I (n = 30) received 15 mg (3 mL) of hyperbaric bupivacaine and Group II (n = 30) received 15 mg (3 mL) of isobaric bupivacaine for spinal anesthesia. Hemodynamic parameters were recorded before and after spinal anesthesia over 30 min. Analyses of HRV were performed on the day of surgery, after volume loading, and 20 min after spinal injection. Low frequency (LF) values, high frequency (HF) …
Prevalence Study Of Genital Tract Infections In Pregnant Women Referred To Health Centers In Iran, Mahmood Mobasheri, Narges Saedi Varnamkhast, Ali Karimi, Shayesteh Banaeiyan
Prevalence Study Of Genital Tract Infections In Pregnant Women Referred To Health Centers In Iran, Mahmood Mobasheri, Narges Saedi Varnamkhast, Ali Karimi, Shayesteh Banaeiyan
Turkish Journal of Medical Sciences
Pregnancy has its own complications such as premature rupture of membranes, preterm delivery, premature birth, low-birth-weight children, and infection. This study aimed to determine the prevalence rate of reproductive tract infections among pregnant women. Materials and methods: In this cross-sectional study, 85 randomly selected pregnant women referred to the ambulatory care facilities of Ardal County, Iran, were recruited via a systematic classified random sampling. Questionnaires, clinical examination by midwives, and laboratory assessments were used to gather the required data. Results: According to the laboratory tests, 71.76% of samples were infectious. Candida albicans (35.76%), Escherichia coli (17.97%), and Streptococcus (13.06%) were …
Expression Of Nadph-D In The Vagal Nuclei Of The Chronic Esophagitis Model In Rats, Ümi̇t Süleyman Şehi̇rli̇, Hali̇l Tuğtepe, Ural Veri̇mli̇, Özlem Ki̇razli, Mazhar Özkan, Emrullah Tolga Dağli
Expression Of Nadph-D In The Vagal Nuclei Of The Chronic Esophagitis Model In Rats, Ümi̇t Süleyman Şehi̇rli̇, Hali̇l Tuğtepe, Ural Veri̇mli̇, Özlem Ki̇razli, Mazhar Özkan, Emrullah Tolga Dağli
Turkish Journal of Medical Sciences
To evaluate the changes in the number of NADPH diaphorase (NADPH-d) stained neurons in the vagal nuclei in a chronic esophagitis model. Materials and methods: There were 3 groups of rats examined: 1) a chronic gastroesophageal reflux rat group, which was created by a partial gastric outlet obstruction; 2) a sham group; and 3) a ranitidine treated group. Serial sections of brainstems of all groups were cut and NADPH-d staining, which selectively stains the nitric acid synthase-containing neurons, was done. Results: Histopathological changes due to chronic reflux esophagitis was observed in the reflux group. The ranitidine treatment and sham control …
A Comparison Of Total Thyroidectomies Carried Out Through Ligasure And Harmonic Scalpel: A Retrospective Study, Kemal Peker, Ayça Tuba Dumanli Özcan, Murat Şahi̇n, Abdullah İnal, Kemal Kiliç, Fati̇h Özçi̇çek
A Comparison Of Total Thyroidectomies Carried Out Through Ligasure And Harmonic Scalpel: A Retrospective Study, Kemal Peker, Ayça Tuba Dumanli Özcan, Murat Şahi̇n, Abdullah İnal, Kemal Kiliç, Fati̇h Özçi̇çek
Turkish Journal of Medical Sciences
Both LigaSure (LS) and Harmonic Scalpel (HS) are new surgical technologies that have been used to secure hemostasis in various fields of surgery. There is little information in the literature about the use of LS and HS in thyroid surgery. The aim of this study was to report our experience with LS and HS in thyroid surgery. Materials and methods: In this nonrandomized retrospective study 326 consecutive patients who underwent primary thyroid surgery were reviewed. HS was used in 136 patients and LS was used in 126 patients. A conventional technique was used in 64 patients. The were 42 male …
The Place Of Androgen Receptor Gene Mutation Analysis In The Molecular Diagnosis Of Prostate Cancer And Genotype–Phenotype Relationship, Fuat Kizilay, Mustafa Serdar Kalemci̇, Adnan Şi̇mşi̇r, Burak Turna, Oktay Nazli, Afi̇g Berdeli̇
The Place Of Androgen Receptor Gene Mutation Analysis In The Molecular Diagnosis Of Prostate Cancer And Genotype–Phenotype Relationship, Fuat Kizilay, Mustafa Serdar Kalemci̇, Adnan Şi̇mşi̇r, Burak Turna, Oktay Nazli, Afi̇g Berdeli̇
Turkish Journal of Medical Sciences
To determine the relationship between androgen receptor (AR) gene polymorphism and prostate cancer in our society. Materials and methods: Thirty-nine patients diagnosed with prostate cancer and 34 benign prostatic hyperplasia (BPH) patients who were diagnosed in 2010 met the study criteria. The inclusion criteria included patients whose diagnosis was confirmed with a biopsy, with the presence of adequate pathologic material for review, between the ages of 40 and 80, and who were healthy men without a family history of prostate cancer. The exclusion criteria excluded men diagnosed with another cancer and those who had kin with a history of prostate …
Comparison Of Different Ligation Techniques In Laparoscopic Varicocelectomy, Yi̇ği̇t Akin, Mutlu Ateş, Selçuk Yücel, Işil Başara, Orçun Çeli̇k, Ali̇seydi̇ Bozkurt, Bariş Nuhoğlu
Comparison Of Different Ligation Techniques In Laparoscopic Varicocelectomy, Yi̇ği̇t Akin, Mutlu Ateş, Selçuk Yücel, Işil Başara, Orçun Çeli̇k, Ali̇seydi̇ Bozkurt, Bariş Nuhoğlu
Turkish Journal of Medical Sciences
To evaluate the effects of different intracorporeal ligation techniques with titanium clips, Plasma Trisector (Gyrus, USA) (PTG), and surgical silk on bilateral laparoscopic varicocelectomy (LPVx). Materials and methods: Between May 2009 and August 2012, 100 patients who underwent bilateral LPVx were evaluated. The demographic parameters of patients, preoperative radiological findings, semen analysis, operative data, and follow-up were recorded. All of the patients were divided into 3 groups, randomized prospectively. The patients whose veins were ligated by 5-mm titanium clips were included in group I, those whose veins were ligated by PTG were included in group II, and those whose veins …
Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer
Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer
Turkish Journal of Medical Sciences
The hepatitis B virus (HBV) is an important healthcare problem. Chronic hepatitis B infection may present with a wide range of manifestations from inactive carrier state to cirrhosis and hepatocellular cancer. Therefore, treatment is very important in chronic hepatitis B. In this study, the treatment results of 199 chronic hepatitis B patients taking entecavir 0.5 mg/day for 48 weeks were evaluated. Materials and methods: This study retrospectively evaluated data of 199 treatment-naive chronic hepatitis B patients who were treated with entecavir. Results: Of the 199 treatment-naive chronic hepatitis B patients, 141 (70.9%) were males and 58 (29.1%) were females, and …
Investigation Of The Effects Of Magnetic Field Exposure On Febrile Seizure Latency, Seizure Duration, And Electroencephalographic Recordings In A Rat Febrile Convulsion Model, Tuncer Demi̇r, Sefa Gültürk, Ayşe Demi̇rkazik Çançalar, Nedi̇m Durmuş
Investigation Of The Effects Of Magnetic Field Exposure On Febrile Seizure Latency, Seizure Duration, And Electroencephalographic Recordings In A Rat Febrile Convulsion Model, Tuncer Demi̇r, Sefa Gültürk, Ayşe Demi̇rkazik Çançalar, Nedi̇m Durmuş
Turkish Journal of Medical Sciences
To investigate the effects of a magnetic field (MF) on febrile seizure latency, seizure duration, and electroencephalographic (EEG) recordings in a rat febrile convulsion model. Materials and methods: Thirty-six rats were randomly allocated into 1 of 6 groups: sham group (S), febrile convulsion (FC) group without MF exposure, MF group without FC, group exposed to MF before FC (MF + FC), group exposed to MF after FC (FC + MF), and group exposed to MF before and after FC (MF + FC + MF). The rectal temperature after febrile seizure induction, seizure latency, seizure duration, and EEG recordings were recorded …
Comparing The Fatty Acid Levels Of Preterm And Term Breast Milk In Turkish Women, İbrahi̇m Aydin, Özden Turan, Fevzi̇ Nuri̇ Aydin, Esi̇n Koç, İbrahi̇m Murat Hirfanoğlu, Mesut Akyol, Muzaffer Öztosun, Emi̇n Özgür Akgül, Hi̇lmi̇ Demi̇ri̇n, Seli̇m Kiliç, Mehmet Kemal Erbi̇l, Taner Özgürtaş
Comparing The Fatty Acid Levels Of Preterm And Term Breast Milk In Turkish Women, İbrahi̇m Aydin, Özden Turan, Fevzi̇ Nuri̇ Aydin, Esi̇n Koç, İbrahi̇m Murat Hirfanoğlu, Mesut Akyol, Muzaffer Öztosun, Emi̇n Özgür Akgül, Hi̇lmi̇ Demi̇ri̇n, Seli̇m Kiliç, Mehmet Kemal Erbi̇l, Taner Özgürtaş
Turkish Journal of Medical Sciences
Lipids are the main source of calories and considered very important in infant growth. We aimed to compare fatty acid composition of term and preterm breast milk. This is the first study that compares the fatty acid levels of preterm and term breast milk in Turkish women. Materials and methods: Breast milk samples were obtained from mothers of term (n = 15) and preterm (n = 15) infants on postnatal days 3, 7, and 28. Fatty acid composition of human breast milk was determined longitudinally by gas-chromatography/mass spectrometry. Results: There were 31 fatty acids measured in the milk samples. In …
Anti Tnf-\Alpha Therapy Might Be Responsible For An Increased Incidence Of Varicocele In Patients With Ankylosing Spondylitis, Ömer Yilmaz, Yunus Ugan, Mahmut Yener, Mehmet Umul, Mustafa Kayan, Aykut Recep Aktaş, Eli̇f Ni̇sa Ünlü, Bünyami̇n Kisacik, Bumi̇n Deği̇rmenci̇, Meltem Çeti̇n
Anti Tnf-\Alpha Therapy Might Be Responsible For An Increased Incidence Of Varicocele In Patients With Ankylosing Spondylitis, Ömer Yilmaz, Yunus Ugan, Mahmut Yener, Mehmet Umul, Mustafa Kayan, Aykut Recep Aktaş, Eli̇f Ni̇sa Ünlü, Bünyami̇n Kisacik, Bumi̇n Deği̇rmenci̇, Meltem Çeti̇n
Turkish Journal of Medical Sciences
To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-\alpha) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound. Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-\alpha treatment and patients with AS who were not regularly taking any antiinflammatory drugs. Thirty-one healthy volunteers were included as controls. Results: Left-sided varicocele was determined in 14 patients of Group 1 (44%), 10 patients of Group 2 (33%), and 7 of the controls (23%). There was a statistically significant difference only between Group 1 and controls (P = …
Hemodynamic Effects Of Chest-Knee Position: Comparison Of Rioperative Propofol And Sevoflurane Anesthesia, Hasan Kutluk Pampal, Yusuf Ünal, Berri̇n Işik, Hati̇ce Zerri̇n Özköse, Recep Şahi̇n Yardim
Hemodynamic Effects Of Chest-Knee Position: Comparison Of Rioperative Propofol And Sevoflurane Anesthesia, Hasan Kutluk Pampal, Yusuf Ünal, Berri̇n Işik, Hati̇ce Zerri̇n Özköse, Recep Şahi̇n Yardim
Turkish Journal of Medical Sciences
There are limited data in the literature investigating the effects of anesthetic agents on cardiac output used in the chest-knee position. The aim of this study is to compare the effects of inhalation and total intravenous anesthesia on cardiac output in patients undergoing lumbar discectomy in the chest-knee position. Materials and methods: Forty patients undergoing discectomy in the chest-knee position were allocated to 2 groups. The first group (GrS, n = 20) received sevoflurane after thiopental induction, while the second group (GrP, n = 20) received propofol induction and infusion. Heart rate (HR), mean arterial pressure (MAP), peripheral oxygen saturation, …
Pediatric Reference Intervals For Plasma And Urine Essential Amino Acids In A Turkish Population, Eni̇s Maci̇t, Murat Kizilgün, Erdi̇nç Çakir, Abdulbaki̇ Karaoğlu, Emi̇n Özgür Akgül, Muzaffer Öztosun, İbrahi̇m Aydin, Fevzi̇ Nuri̇ Aydin, Mehmet Ağilli, Türker Türker, Recai̇ Oğur, Yasemi̇n Gülcan Kurt, Hüsametti̇n Gül, Tuncer Çayci, Esi̇n Özkan
Pediatric Reference Intervals For Plasma And Urine Essential Amino Acids In A Turkish Population, Eni̇s Maci̇t, Murat Kizilgün, Erdi̇nç Çakir, Abdulbaki̇ Karaoğlu, Emi̇n Özgür Akgül, Muzaffer Öztosun, İbrahi̇m Aydin, Fevzi̇ Nuri̇ Aydin, Mehmet Ağilli, Türker Türker, Recai̇ Oğur, Yasemi̇n Gülcan Kurt, Hüsametti̇n Gül, Tuncer Çayci, Esi̇n Özkan
Turkish Journal of Medical Sciences
To establish age- and sex-specific reference intervals for essential amino acids in a healthy Turkish pediatric population. Materials and methods: A total of 945 clinically healthy children (531 boys and 414 girls, ranging in age from birth to 14 years) were enrolled. Plasma and urine amino acids' concentrations were measured by high-performance liquid chromatography. Results: Concentrations of essential amino acids in plasma were higher in girls than in boys in the age groups of 0-1 months and 7-14 years; however, there was no difference in the other age groups. Concentrations of essential amino acids in urine were higher in girls …
Tc-99m Mdp Bone Scintigraphy In The Evaluation Of The Joint Damage In Asymptomatic Alpine Ski Racers, Erhan Varoğlu, Mustafa Yildirim, Recep Gürsoy, Bedri̇ Seven, Hati̇ce Uslu, Şi̇rzat Çoğalgi̇l, Fati̇h Kiyici
Tc-99m Mdp Bone Scintigraphy In The Evaluation Of The Joint Damage In Asymptomatic Alpine Ski Racers, Erhan Varoğlu, Mustafa Yildirim, Recep Gürsoy, Bedri̇ Seven, Hati̇ce Uslu, Şi̇rzat Çoğalgi̇l, Fati̇h Kiyici
Turkish Journal of Medical Sciences
To evaluate the role of 99m-technetium methylene diphosphonate (Tc-99m MDP) bone scintigraphy on the detection of joint damage in asymptomatic alpine ski racers. Materials and methods: This study included 20 male asymptomatic alpine ski racers (age range: 18-21 years). None of the skiers had a history of ski crashes. Bone scan findings of the racers were examined with Tc-99m MDP bone scintigraphy during the active racing season and the inactive training season. Planar anterior and posterior images of hip, knee, and ankle joints were obtained 4 h after intravenous injection of 20 mCi Tc-99m MDP. All images were interpreted visually …
Clinical And Prognostic Importance Of Chromosomal Abnormalities, Y Chromosome Microdeletions, And Cftr Gene Mutations In Individuals With Azoospermia Or Severe Oligospermia, Zeynep Ocak, Uğur Üyetürk, Muhammet Murat Di̇nçer
Clinical And Prognostic Importance Of Chromosomal Abnormalities, Y Chromosome Microdeletions, And Cftr Gene Mutations In Individuals With Azoospermia Or Severe Oligospermia, Zeynep Ocak, Uğur Üyetürk, Muhammet Murat Di̇nçer
Turkish Journal of Medical Sciences
To illustrate the importance of genetic screening in the assessment of fertility and the correct diagnosis in patients with azoospermia or severe oligospermia. Materials and methods: This study examined 500 patients with reproductive failure, having fewer than 5 million sperm/mL detected in at least 2 consecutive spermiograms, who presented at a medical genetics polyclinic between 2008 and 2012. Metaphase preparations obtained from cell cultures were stained by trypsin-Giemsa banding. After DNA isolation, Y chromosome loci, including AZFa (SY84, SY86), AZFb (SY127, SY134), AZFc (SY254 SY255), and AZFd, were amplified by polymerase chain reaction using specific primers. Thirty-five patients with congenital …
Effects Of The Medial Or Basolateral Amygdala Upon Social Anxiety And Social Recognition In Mice, Yu Wang, Shanshan Zhao, Xu Liu, Qunying Fu
Effects Of The Medial Or Basolateral Amygdala Upon Social Anxiety And Social Recognition In Mice, Yu Wang, Shanshan Zhao, Xu Liu, Qunying Fu
Turkish Journal of Medical Sciences
Though social anxiety and social recognition have been studied extensively, the roles of the medial or basolateral amygdala in the control of social anxiety and social recognition remain to be determined. This study investigated the effects of excitotoxic bilateral medial or basolateral amygdala lesions upon social anxiety and social recognition in mice. Materials and methods: Animals at 9 weeks of age were given bilateral medial or basolateral amygdala lesions via infusion of N-methyl-D-aspartate and then were used for behavioral tests: anxiety-related tests (including open-field test, light-dark test, and elevated-plus maze test), social behavior test in a novel environment, social recognition …
Neutrophil-Lymphocyte Ratio As A Predictive Factor For Tumor Staging In Colorectal Cancer, Gülay Özgehan, Şahi̇n Kahramanca, İsmai̇l Oskay Kaya, Köksal Bi̇lgen, Hasan Bostanci, Hakan Güzel, Tevfi̇k Hadi̇ Küçükpinar, Hülagü Kargici
Neutrophil-Lymphocyte Ratio As A Predictive Factor For Tumor Staging In Colorectal Cancer, Gülay Özgehan, Şahi̇n Kahramanca, İsmai̇l Oskay Kaya, Köksal Bi̇lgen, Hasan Bostanci, Hakan Güzel, Tevfi̇k Hadi̇ Küçükpinar, Hülagü Kargici
Turkish Journal of Medical Sciences
In the preoperative period, simple methods to identify the tumor stage of colorectal cancer patients are needed. In recent years, the neutrophil-lymphocyte ratio (NLR) has been used as a predictive parameter for systemic inflammatory response in many different clinical entities. This study aims to determine if the NLR predicts the tumor stage in colorectal cancer patients in the preoperative period. Materials and methods: A total of 206 patients diagnosed with colorectal cancer and admitted for surgical treatment over a 6-year period were identified from a retrospectively maintained database. NLR was calculated from preoperative full blood counts. NLRs were compared with …
Chronic Moderate Alcohol Consumption Induces Inos Expression In The Penis: An Immunohistochemical Study, Süheyla Gonca, Yusufhan Yazir, Semi̇l Selcen Göçmez, Eki̇m Nur Dalçik, Ti̇jen Utkan, Hakki Dalçik
Chronic Moderate Alcohol Consumption Induces Inos Expression In The Penis: An Immunohistochemical Study, Süheyla Gonca, Yusufhan Yazir, Semi̇l Selcen Göçmez, Eki̇m Nur Dalçik, Ti̇jen Utkan, Hakki Dalçik
Turkish Journal of Medical Sciences
To investigate the effect of moderate alcohol consumption on metabolic alterations, inducible nitric oxide synthase (iNOS), immunohistochemical distribution, and morphological damage to penile erectile tissue in rats. Materials and methods: Male Wistar albino rats were divided into 2 groups. Group 1 rats (control group, n = 8) received tap water ad libitum, and group 2 rats (n = 8) were fed with 20% ethanol. Increasing levels of alcohol were given to the rats over 12 weeks. Immunohistochemistry was then performed using the avidin-biotin-peroxidase technique on 5-um thickness tissue sections. Stained sections were examined by imaging microscope. Results: Alcohol consumption resulted …
Protective Effects Of Montelukast And Hypericum Perforatum Against Intestinal Ischemia-Reperfusion Injury In Hamsters, Tarik Ocak, Ari̇f Duran, Gülzade Özyalvaçli, Zeynep Ocak, Elçi̇n Hakan Terzi̇, Mehmet Tosun, Kemaletti̇n Erdem
Protective Effects Of Montelukast And Hypericum Perforatum Against Intestinal Ischemia-Reperfusion Injury In Hamsters, Tarik Ocak, Ari̇f Duran, Gülzade Özyalvaçli, Zeynep Ocak, Elçi̇n Hakan Terzi̇, Mehmet Tosun, Kemaletti̇n Erdem
Turkish Journal of Medical Sciences
To evaluate the effects of montelukast and Hypericum perforatum against ischemia/reperfusion (I/R)-induced intestinal damage. Materials and methods: Twenty-eight hamsters were divided into 4 groups following midline abdominal laparotomy: control group (n = 7), I/R group (n = 7), montelukast and I/R (MIR) group (n = 7), and Hypericum perforatum and I/R (HPIR) group (n = 7). After 60 min of ischemia through obstruction of the superior mesenteric artery, 24 h of reperfusion was maintained. Ten minutes prior to the reperfusion period, the MIR group received 7 mg/kg of intraperitoneal montelukast and the HPIR group received 7 mg/kg of intraperitoneal Hypericum …
Gleason Score At The Margin Can Predict Biochemical Recurrence After Radical Prostatectomy, In Addition To Preoperative Psa And Surgical Margin Status, Sidika Şeyma Özkanli, Itir Ebru Zemheri̇, Asif Yildirim, Hati̇ce Deni̇z Gür, Mevlana Derya Balbay, Serkan Şenol, Ahmet Oğuz Özkanli, Erdal Alkan, Tülay Zengi̇nki̇net, Abdullah Aydin, Turhan Çaşkurlu
Gleason Score At The Margin Can Predict Biochemical Recurrence After Radical Prostatectomy, In Addition To Preoperative Psa And Surgical Margin Status, Sidika Şeyma Özkanli, Itir Ebru Zemheri̇, Asif Yildirim, Hati̇ce Deni̇z Gür, Mevlana Derya Balbay, Serkan Şenol, Ahmet Oğuz Özkanli, Erdal Alkan, Tülay Zengi̇nki̇net, Abdullah Aydin, Turhan Çaşkurlu
Turkish Journal of Medical Sciences
To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels. Materials and methods: A total of 94 patients who underwent radical prostatectomy were recruited for this study and received postoperative follow-up care for 2 years. All specimens were evaluated for surgical margin status, PSM length, GS at positive margin, size of tumor, multifocality, invasion of seminal vesicle, lymphovascular invasion, and perineural invasion. PSM was defined as a prostate tumor. Results: Out of 94 patients, 34 patients …
Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan
Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan
Turkish Journal of Medical Sciences
To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment …
Relation Of Age And Sex With Carotid Intima Media Thickness In Healthy Children, Ali̇ Koçyi̇ği̇t, Mustafa Doğan, İsmai̇l Yilmaz, Murat Çağlar, Celi̇le Hati̇poğlu, Fi̇gen Koçyi̇ği̇t, Duygu Herek, Nevzat Karabulut
Relation Of Age And Sex With Carotid Intima Media Thickness In Healthy Children, Ali̇ Koçyi̇ği̇t, Mustafa Doğan, İsmai̇l Yilmaz, Murat Çağlar, Celi̇le Hati̇poğlu, Fi̇gen Koçyi̇ği̇t, Duygu Herek, Nevzat Karabulut
Turkish Journal of Medical Sciences
To investigate the age- and sex-associated carotid intima media thickness (cIMT) changes in healthy children to determine the age- and sex-specific normal range of values for childhood. Materials and methods: This study examined 91 healthy school-age children aged 7-15 years prospectively. Standardized sonographic cIMT measurements and analyses were performed. Body mass index and blood pressure were obtained, and atherosclerotic risk factors were investigated. Age-and sex-specific cIMT measurements for different age groups were calculated and the relation with sex was investigated. Results: Regarding the total study group, mean cIMT measurements for age groups 7-9, 10-12, and 13-15 years were 4.1 ± …
Is Trichoscan A New Diagnostic Method For Diffuse Hair Loss?, Hati̇ce Uce Özkol, Ömer Çalka, Necmetti̇n Akdeni̇z
Is Trichoscan A New Diagnostic Method For Diffuse Hair Loss?, Hati̇ce Uce Özkol, Ömer Çalka, Necmetti̇n Akdeni̇z
Turkish Journal of Medical Sciences
In this study, we investigated the sensitivity of TrichoScan, a computer-based phototrichogram, in the evaluation of diffuse hair loss in women and the relationship between iron deficiency anemia and hair loss. Materials and methods: We recruited 100 female patients with diffuse hair loss. In all of the patients, a 1-cm2 area of hair located in a temporoparietal region was shortened to 0.5 mm. The shaved scalp regions were stained with black dye. The subject then waited for 12 min. Subsequently, pictures of these regions were taken with a videodermoscope and analyzed with the TrichoScan software program. Results: The ferritin levels …
Neuropharmacological Effects Of Methanolic Extracts Of Rubus Fruticosus L., Muhammad Riaz, Muhammad Zia-Ul-Haq, Najm Ur-Rahman, Mansoor Ahmad
Neuropharmacological Effects Of Methanolic Extracts Of Rubus Fruticosus L., Muhammad Riaz, Muhammad Zia-Ul-Haq, Najm Ur-Rahman, Mansoor Ahmad
Turkish Journal of Medical Sciences
To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities. Materials and methods: The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming test, while line crossing in a special box was used for assessment of locomotor activity. Results: All extracts were found to be anxiolytic in nature, while no muscle relaxing activity or sedative effect was observed. The order of central nervous system (CNS) depressant effect for various …
Detection Of Kinase Amplifications In Gastric Adenocarcinomas, Muhsi̇n Özdemi̇r, Murat Öznur, Evri̇m Çi̇ftçi̇, Beyhan Durak Aras, Hüseyi̇n Aslan, Hande Saygili, Kevser Setenay Öner, Serdar Mustafa Erkasap, Ayşegül Özakyol, Özgül Paşaoğlu, Oğuz Çi̇li̇ngi̇r, Sevi̇lhan Artan
Detection Of Kinase Amplifications In Gastric Adenocarcinomas, Muhsi̇n Özdemi̇r, Murat Öznur, Evri̇m Çi̇ftçi̇, Beyhan Durak Aras, Hüseyi̇n Aslan, Hande Saygili, Kevser Setenay Öner, Serdar Mustafa Erkasap, Ayşegül Özakyol, Özgül Paşaoğlu, Oğuz Çi̇li̇ngi̇r, Sevi̇lhan Artan
Turkish Journal of Medical Sciences
To determine the incidences of copy number aberrations of receptor kinases and their relations in Turkish patients with gastric adenocarcinoma. Materials and methods: The prevalence of genomic copy number aberrations of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2)/topoisomerase IIa (TOP2A), centrosome-associated kinase aurora A (AURK A), centrosome-associated kinase aurora B (AURK B), and mesenchymal-epithelial transition factor (MET) genes and polysomies of related chromosomes were analyzed by fluorescent in situ hybridization (FISH) in tumor samples from 35 patients with gastric cancer. Results: There were 28.6%, 65.7%, 20.0%, 17.1%, 60.0%, and 45.7% cases considered FISH-positive for EGFR, …