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Articles 2851 - 2880 of 4871
Full-Text Articles in Medicine and Health Sciences
Oxaliplatin And Ototoxicity: Is It Really Safe For Hearing?, Sali̇m Yüce, Mehmet Meti̇n Şeker, Sema Koç, İsmai̇l Önder Uysal, Turgut Kaçan, Mehtap Doğan, Mansur Doğan, Nalan Akgül Babacan, Saadetti̇n Kiliçkap
Oxaliplatin And Ototoxicity: Is It Really Safe For Hearing?, Sali̇m Yüce, Mehmet Meti̇n Şeker, Sema Koç, İsmai̇l Önder Uysal, Turgut Kaçan, Mehtap Doğan, Mansur Doğan, Nalan Akgül Babacan, Saadetti̇n Kiliçkap
Turkish Journal of Medical Sciences
Oxaliplatin is an effective and widely used chemotherapeutic agent in the treatment of many solid tumors. The most common side effects are peripheral neuropathy, gastrointestinal toxicity, and neutropenia. There have been some case reports about ototoxicity with oxaliplatin, but no clinical trials. In this trial, we explored whether or not oxaliplatin has ototoxic effects. Materials and methods: A total of 18 patients, 14 with colorectal cancer and 4 with pancreatic cancer, were included in this study. Four patients (22%) were treated with a capecitabine and oxaliplatin (CapeOx) regimen, and 14 patients (78%) were treated with fluorouracil, leucovorin, and oxaliplatin (FOLFOX-6). …
Pharmacological Profile Of A Nitric Oxide Donor Spermine Nonoate In The Mouse Corpus Cavernosum, Fatma Peyman Ertuğ, Erği̇n Şi̇ngi̇ri̇k, Hacer Si̇nem Büyüknacar, Cemi̇l Göçmen, Mehmet Ata Seçi̇lmi̇ş
Pharmacological Profile Of A Nitric Oxide Donor Spermine Nonoate In The Mouse Corpus Cavernosum, Fatma Peyman Ertuğ, Erği̇n Şi̇ngi̇ri̇k, Hacer Si̇nem Büyüknacar, Cemi̇l Göçmen, Mehmet Ata Seçi̇lmi̇ş
Turkish Journal of Medical Sciences
To investigate the effects of spermine NONOate in the cavernous tissue obtained from mice treated or untreated with sildenafil. Materials and methods: We studied the effects of spermine NONOate on the tone and nitrergic relaxation responses of isolated mouse corpus cavernosum and compared them with sodium nitroprusside in the absence or presence of L-nitroarginine, hydroxocobalamin, pyrogallol, diethyldithiocarbamate (DETCA), or 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ). The neurogenic contractions and relaxations of the tissues were induced by electrical field stimulation. Some mice received a single oral dose of sildenafil and after 1 h the effects of spermine NONOate were evaluated by in vitro studies. Results: …
The Comparison Of Folate And Vitamin B12 Levels Between Depressive And Nondepressive Postmenopausal Women, Özlem Şengül, Di̇lek Uygur, Mustafa Güleç, Berna Di̇lbaz, Esma Meltem Şi̇mşek, Ümi̇t Göktolga
The Comparison Of Folate And Vitamin B12 Levels Between Depressive And Nondepressive Postmenopausal Women, Özlem Şengül, Di̇lek Uygur, Mustafa Güleç, Berna Di̇lbaz, Esma Meltem Şi̇mşek, Ümi̇t Göktolga
Turkish Journal of Medical Sciences
To investigate if there is any association between the serum folate and vitamin B12 status and the depressive symptoms in postmenopausal women. Materials and methods: The study included 95 postmenopausal women. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess their depressive symptoms. The investigated women were classified into 2 groups based on the existence of depressive symptoms. These 2 groups were compared in terms of folic acid and vitamin B12 levels. Results: Among 95 cases, 27 postmenopausal women scored 16 or more on the CES-D scale and were classified as the depressive group (Group 1), and …
Incidence Of Maternal Vitamin D Deficiency In A Region Of Ankara, Turkey: A Preliminary Study, Gökçe Gür, Ayhan Abaci, Adem Yasi̇n Köksoy, Ahmet Anik, Gönül Çatli, Fati̇h Mehmet Kişlal, Kadi̇r Okhan Akin, Nesi̇be Andiran
Incidence Of Maternal Vitamin D Deficiency In A Region Of Ankara, Turkey: A Preliminary Study, Gökçe Gür, Ayhan Abaci, Adem Yasi̇n Köksoy, Ahmet Anik, Gönül Çatli, Fati̇h Mehmet Kişlal, Kadi̇r Okhan Akin, Nesi̇be Andiran
Turkish Journal of Medical Sciences
To evaluate vitamin D levels and risk factors for vitamin D deficiency in healthy newborns and their mothers. Materials and methods: Ninety-nine healthy pregnant women (≥37 weeks of gestation) were enrolled in the study. Previous history of pregnancies and births, nutritional status, multivitamin supplementation, educational status, type of clothing, and the economic level of the family were recorded. Blood samples were drawn from the mothers and the umbilical cord of the newborns to measure serum 25(OH)D3, calcium, phosphorus, and parathormone levels. Results: While vitamin D insufficiency was identified as 62.6% in mothers, it was 58.6% in newborns; on the other …
Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir
Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir
Turkish Journal of Medical Sciences
To assess whether osteocytes have an effect on reflex myoelectrical activity during whole-body vibration (WBV) in postmenopausal women. Materials and methods: Participants were classified into 2 groups: the low bone mineral density (BMD) group (n = 37) and normal BMD group (n = 43). Hip BMD was measured using dual-energy X-ray absorptiometry. Surface electromyography data recorded from the adductor longus muscle were processed to obtain vibration-induced reflex myoelectrical activity. Changes in plasma sclerostin (SOST) levels with WBV were expressed as a standardized vibration-induced SOST index. Results: The standardized vibration-induced SOST index was 1.03 ± 0.24 in the low BMD group …
Determining Torsion Angle Of Humerus Head Using Mri Method, Ayfer Meti̇n Telli̇oğlu, Saci̇de Karakaş, Füsun Taşkin
Determining Torsion Angle Of Humerus Head Using Mri Method, Ayfer Meti̇n Telli̇oğlu, Saci̇de Karakaş, Füsun Taşkin
Turkish Journal of Medical Sciences
To measure the torsion angle of the humerus using images obtained via magnetic resonance imaging (MRI) in healthy volunteers and to evaluate outcomes with respect to sex and age groups. Materials and methods: The study consisted of 36 healthy adults (18 males and 18 females aged between 20 and 68 years). The humeral torsion angle (HTA) was calculated using axial MRI images. Differences between results in terms of sex and age groups were evaluated with the Mann-Whitney U test. Results: The median HTA was 21.5° (25th to 75th percentile: 7.8°-28°; range: -4° to 36°) in females, while it was 18.5° …
Clonal Comparison Of Acinetobacter Strains Isolated From Intensive Care Patients And The Intensive Care Unit Environment, Esra Kirkgöz, Yasemi̇n Zer
Clonal Comparison Of Acinetobacter Strains Isolated From Intensive Care Patients And The Intensive Care Unit Environment, Esra Kirkgöz, Yasemi̇n Zer
Turkish Journal of Medical Sciences
Acinetobacter baumannii is one of the most commonly encountered microorganisms in nosocomial infections. It is thought that strains found in the environment can be a source for contamination of patients by Acinetobacter strains that are resistant to environmental conditions. This study was carried out to compare Acinetobacter strains isolated from a variety of nonviable environments and from patients in intensive care units (ICUs), and to explore whether environmental areas may be a source for bacterial contamination. Materials and methods: We studied A. baumannii strains isolated from ICU patients. When A. baumannii was isolated from the clinical sample of a patient, …
Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya
Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya
Turkish Journal of Medical Sciences
To better understand the knowledge, attitudes, and demographic factors that influence the rate of influenza vaccination among high socioeconomic status parents. Materials and methods: questionnaire exploring the attitudes of parents to the influenza vaccine, and their knowledge about influenza and its vaccination, was given to parents of children from 1 through 16 years of age attending the Turgut Özal University Hospital after the 2011/12 influenza season. Results: In the present study, 285 mothers and their children participated and 8.8% (n = 25) of children had the influenza vaccination. Between the vaccinated and nonvaccinated groups, there were statistically significantly differences for …
Hepatitis C Virus Genotypes In Adana And Antakya Regions Of Turkey, Agah Bahadir Öztürk, Ümi̇t Bi̇lge Doğan, Nevi̇n Akçaer Öztürk, Gonca Özyazici, Mehmet Demi̇r, Mustafa Sali̇h Akin, Ali̇ Suha Bi̇ngöl
Hepatitis C Virus Genotypes In Adana And Antakya Regions Of Turkey, Agah Bahadir Öztürk, Ümi̇t Bi̇lge Doğan, Nevi̇n Akçaer Öztürk, Gonca Özyazici, Mehmet Demi̇r, Mustafa Sali̇h Akin, Ali̇ Suha Bi̇ngöl
Turkish Journal of Medical Sciences
Hepatitis C virus (HCV) genotype 1 was found to be dominant in Turkey. In this study, HCV genotypes were examined in the Adana and Antakya regions of Turkey. Materials and methods: The study consisted of 639 HCV-RNA–positive patients with chronic HCV infection in Adana (214 males and 101 females) and Antakya (139 males and 185 females) in Turkey. Real time-polymerase chain reaction was used for genotype determination. Results: In Antakya, it was determined that the percentages of genotypes of type 1a (0.31%), 1b (86.73%), 2 (9.26%), 3 (0.93%), and 4 (2.78%) were compatible with the nationwide results seen in Turkey. …
The Relationship Between Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia And Erectile Dysfunction: The Role Of Autonomic Hyperactivity, Mehmet Umul, Ahmet Bariş Altay, Fi̇kret Bademkiran, Burak Turna, Mehmet Bülent Semerci̇, Erdal Apaydin, Necmetti̇n Çikili
The Relationship Between Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia And Erectile Dysfunction: The Role Of Autonomic Hyperactivity, Mehmet Umul, Ahmet Bariş Altay, Fi̇kret Bademkiran, Burak Turna, Mehmet Bülent Semerci̇, Erdal Apaydin, Necmetti̇n Çikili
Turkish Journal of Medical Sciences
To investigate whether autonomic nervous system (ANS) hyperactivity may be a potential cause for the relationship between lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Materials and methods: Twenty-four patients were recruited for this study. Complete physical examinations, urine analysis, uroflowmetry, and postvoid residual urine volume (PVRU) analysis were performed. The potential impact of some factors such as hyperglycemia, obesity, and hyperlipidemia were analyzed. These values were correlated with the various symptom scores. We performed an electromyographic and an electrocardiographic evaluation. The alterations after treatment with 2 different alpha-blockers were also analyzed. Results: The electromyographic and electrocardiographic assessments revealed …
The Effect Of Lateral Internal Sphincterotomy On Resting Anal Sphincter Pressures, Kemal Peker, İsmayi̇l Yilmaz, İsmai̇l Demi̇ryilmaz, Abdullah İnal, Arda Işik
The Effect Of Lateral Internal Sphincterotomy On Resting Anal Sphincter Pressures, Kemal Peker, İsmayi̇l Yilmaz, İsmai̇l Demi̇ryilmaz, Abdullah İnal, Arda Işik
Turkish Journal of Medical Sciences
Anal fissures are one of the most common proctologic disorders. This study aimed to investigate alterations in anal sphincteric resting pressures after lateral internal sphincterotomy, which was performed for chronic anal fissure treatment. Materials and methods: Fifty-six (68.3%) male and 26 (31.7%) female patients were included in this study. Patients complicated with fistula-in-ano, abscess, cancer, inflammatory bowel disease, dermatitis, poor general condition, allergy to any of the standard medications, previous history of anal trauma, previous anal surgery, or diagnosis of a neurological disease and patients who did not give consent to the trial were excluded from the study. Two groups …
Early Graft Dysfunction And Mortality Rate In Marginal Donor Liver Transplantation, Pinar Sarkut, Bariş Gülcü, Remzi̇ İşçi̇men, Murat Kiyici, Gürkan Türker, Nai̇le Bolca Topal, Yilmaz Özen, Ekrem Kaya
Early Graft Dysfunction And Mortality Rate In Marginal Donor Liver Transplantation, Pinar Sarkut, Bariş Gülcü, Remzi̇ İşçi̇men, Murat Kiyici, Gürkan Türker, Nai̇le Bolca Topal, Yilmaz Özen, Ekrem Kaya
Turkish Journal of Medical Sciences
To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients. Materials and methods: Donors with any 1 of following were considered marginal donors: age =>65 years, sodium level =>165 mmol/L and cold ischemia time =>12 h. Donors were classified according to the donor risk index (DRI) 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if 20. Early graft dysfunction (EGD) and mortality rate were evaluated. Results: During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients …
Comparison Of High-Resolution Melting Analysis To Denaturing High Performance Liquid Chromatography In The Detection Of Point Mutations In Mefv, F5, And F2 Genes, Hülya Sümer Çelebi̇, Hi̇lal Özdağ
Comparison Of High-Resolution Melting Analysis To Denaturing High Performance Liquid Chromatography In The Detection Of Point Mutations In Mefv, F5, And F2 Genes, Hülya Sümer Çelebi̇, Hi̇lal Özdağ
Turkish Journal of Medical Sciences
Sensitive and cost-effective detection of point mutations is important in genetics research. Denaturing high-performance liquid chromatography (DHPLC) is known to be one of the most sensitive techniques for point mutation detection. A more recent technique, high-resolution melting (HRM), is based on the melting behavior of PCR products. In this study, the efficiency and sensitivity of HRM and DHPLC for the detection of MEFV, F5, and F2 gene point mutations were evaluated. Materials and methods: We studied 15 patients with MEFV mutations (E148Q, M680I, M694V, or V726A), 7 patients with the F51691G>A mutation, and 12 patients with the F220210G>A …
Evaluation And Comparison Of Alpha- And Beta-Amanitin Toxicity On Mcf-7 Cell Line, Ertuğrul Kaya, Recep Bayram, Kürşat Oğuz Yaykaşli, İsmai̇l Yilmaz, Sai̇t Bayram, Emi̇ne Yaykaşli, Muhsi̇ne Zeynep Yavuz, Ali̇ Akçahan Gepdi̇remen
Evaluation And Comparison Of Alpha- And Beta-Amanitin Toxicity On Mcf-7 Cell Line, Ertuğrul Kaya, Recep Bayram, Kürşat Oğuz Yaykaşli, İsmai̇l Yilmaz, Sai̇t Bayram, Emi̇ne Yaykaşli, Muhsi̇ne Zeynep Yavuz, Ali̇ Akçahan Gepdi̇remen
Turkish Journal of Medical Sciences
Alpha- and beta-amanitins are the main toxins of the poisonous Amanita phalloides mushroom. Although there are many studies available concerning alpha-amanitin, there are limited data about beta-amanitin in the literature. Therefore, this study is aimed at comparing the toxic effects of alpha- and beta-amanitin on the MCF-7 cell line. Materials and methods: The alpha- and beta-amanitins used for this research were purified from Amanita phalloides by preparative high-performance liquid chromatography. The MCF-7 breast cancer cell line was used, and specific concentrations of the toxins (100, 10, 1, 0.1, and 0.01 µg/mL) were applied to the cells. The MTT test was …
The Effect Of Malaysian Honey And Its Major Components On The Proliferation Of Cultured Fibroblasts, Al-Mahdi Al-Jadi, Francis Kanyang Enchang, Kamaruddi̇n Mohd Yusoff
The Effect Of Malaysian Honey And Its Major Components On The Proliferation Of Cultured Fibroblasts, Al-Mahdi Al-Jadi, Francis Kanyang Enchang, Kamaruddi̇n Mohd Yusoff
Turkish Journal of Medical Sciences
To examine, for the first time, the effect of a selected Malaysian honey and its major components on the proliferation of cultured fibroblasts. Materials and methods: Honey and some of its components, which include the sugars, the proteins, the hydrogen peroxide produced, and the phenolics, were exposed to cultured fibroblasts. The MTT colorimetric assay was used to assess cell viability and proliferation. Results: The stimulatory effect of honey on fibroblast proliferation was observed to be time- and dose-dependent. The continuous production of hydrogen peroxide by the honey-glucose oxidase system also acts to stimulate cell proliferation in a time- and dose-dependent …
Molecular Discrimination Of Echinococcus Granulosus And Echinococcus Multilocularis By Sequencing And A New Pcr-Rflp Method With The Potential Use For Other Echinococcus Species, Çağri Şakalar, Sali̇h Kuk, Ahmet Erensoy, Adi̇le Ferda Dağli, İbrahi̇m Hani̇fi̇ Özercan, Ülfet Çeti̇nkaya, Süleyman Yazar
Molecular Discrimination Of Echinococcus Granulosus And Echinococcus Multilocularis By Sequencing And A New Pcr-Rflp Method With The Potential Use For Other Echinococcus Species, Çağri Şakalar, Sali̇h Kuk, Ahmet Erensoy, Adi̇le Ferda Dağli, İbrahi̇m Hani̇fi̇ Özercan, Ülfet Çeti̇nkaya, Süleyman Yazar
Turkish Journal of Medical Sciences
To develop a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol using a new genomic marker sequence and a novel set of restriction enzymes in order to detect and discriminate 2 Echinococcus species, E. granulosus and E. multilocularis, found in formalin-fixed paraffin-embedded (FFPE) human tissues. Materials and methods: DNA was isolated from 11 FFPE human tissue samples positive for cystic echinococcosis or alveolar echinococcosis. A mitochondrial genomic marker region was amplified and sequenced using a novel primer pair and a new PCR-RFLP protocol was developed for the detection and discrimination of E. granulosus and E. multilocularis using a set …
Effects Of Ozone Therapy And Taurine On Ischemia/Reperfusion-Induced Testicular Injury In A Rat Testicular Torsion Model, Tolga Reşat Aydos, Mehmet Murad Başar, Oğuz Kul, Hasan Tarik Atmaca, Tuba Uzunali̇oğlu, Üçler Kisa, Oğuzhan Eki̇n Efe
Effects Of Ozone Therapy And Taurine On Ischemia/Reperfusion-Induced Testicular Injury In A Rat Testicular Torsion Model, Tolga Reşat Aydos, Mehmet Murad Başar, Oğuz Kul, Hasan Tarik Atmaca, Tuba Uzunali̇oğlu, Üçler Kisa, Oğuzhan Eki̇n Efe
Turkish Journal of Medical Sciences
To investigate the effect of ozone and/or taurine treatment comparatively on testicular damage due to ischemia/reperfusion (I/R) injury in an experimental torsion model in rats. Materials and methods: Adult Wistar rats with and without torsion/detorsion were used. In order to monitor the effect of ozone and/or taurine treatment on testicular damage due to I/R injury, following histopathological investigation apoptotic indexes were scored by TUNEL method. Moreover, tumor necrosis factor receptor 1 (TNFR1), caspase 3, caspase 8, endothelial nitric oxide synthase (eNOS), tumor necrosis factor alpha (TNF\alpha), and cytochrome C immunostainings were performed and the levels of malondialdehyde, glutathione peroxidase, superoxide …
Early Extracorporeal Life Support Experiences In 2 Tertiary Pediatric Intensive Care Units In Turkey, Makbule Ni̇lüfer Öztürk, Koray Ak, Ni̇lgün Erkek, Edanur Yeşi̇l, Muhterem Duyu, Pinar Yazici, Ayşen Yaprak Engi̇n, Bülent Karapinar
Early Extracorporeal Life Support Experiences In 2 Tertiary Pediatric Intensive Care Units In Turkey, Makbule Ni̇lüfer Öztürk, Koray Ak, Ni̇lgün Erkek, Edanur Yeşi̇l, Muhterem Duyu, Pinar Yazici, Ayşen Yaprak Engi̇n, Bülent Karapinar
Turkish Journal of Medical Sciences
Extracorporeal membrane oxygenation (ECMO) is a unique life-support modality offered to patients unresponsive to optimal medical therapy. The aim of this study was to evaluate early experiences with ECMO support in 2 tertiary Turkish pediatric intensive care units (PICUs). Materials and methods: We retrospectively evaluated a total of 10 ECMO-supported patients between March 2012 and March 2013 in Marmara and Ege University Hospital PICUs. We reported data regarding demographics, laboratory and diagnostic information, and the clinical course of the patients. Results: The study consisted of 6 males and 4 females from 5 months to 14 years of age (mean age: …
Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi
Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi
Turkish Journal of Medical Sciences
Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH). Materials and methods: This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects. Results: Mean IGF-I levels and median ALT levels were higher in patients with IH and …
Investigating The Effects Of Negative-Calorie Diet Compared With Low-Calorie Diet Under Exercise Conditions On Weight Loss And Lipid Profile In Overweight/Obese Middle-Aged And Older Men, Mohammadreza Rezaeipour, Gennady Leonidovich Apanasenko, Vladimir Ivanovich Nychyporuk
Investigating The Effects Of Negative-Calorie Diet Compared With Low-Calorie Diet Under Exercise Conditions On Weight Loss And Lipid Profile In Overweight/Obese Middle-Aged And Older Men, Mohammadreza Rezaeipour, Gennady Leonidovich Apanasenko, Vladimir Ivanovich Nychyporuk
Turkish Journal of Medical Sciences
Negative-calorie diets (NCDs) are among the popular dieting guides for weight loss; however, there is still little knowledge about this method. The present study aimed to determine the effects of a NCD supplemented with exercise on weight loss and lipid profile, and to compare its efficiency with low-calorie diets (LCDs) with exercise among elderly adult men with abnormal weight gain. Materials and methods: Participants included sedentary men (aged 45-75 years) who were overweight or obese (n = 37). They were randomly divided into 2 groups: a group with a NCD and exercise, and a group with a LCD with exercise. …
Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim
Airway Inflammation And Tiotropium Treatment In Stable Copd Patients, Duygu Özol, Harun Karamanli, Sema Uysal, Muhammet Ramazan Yi̇ği̇toğlu, Zeki̇ Yildirim
Turkish Journal of Medical Sciences
Chronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lung associated with progressive airflow limitation. The aim of this study is to assess the influence of tiotropium treatment on airway inflammation and symptoms in stable COPD patients. Materials and methods: Inflammatory markers were measured in the expired breath condensate fluid (EBC) before starting tiotropium treatment and at the end of the first month. Results: Twenty-two patients (81% men) with a mean age of 65.4 ± 10.1 years completed the study. The mean nitrotyrosine and 8-isoprostane levels for oxidative stress markers in EBC before and after treatment were 4.5 …
Leptin And Leptin Receptor Polymorphisms Are Related To Body Mass Index In A Turkish Population, Uzay Görmüş, Özlem Ti̇mi̇rci̇ Kahraman, Bahar Toptaş, Turgay İsbi̇r, Çavlan Çi̇ftçi̇, Hasan Hakan Berkkan, Altay Burak Dalan, Muti̇a Canan Karatay
Leptin And Leptin Receptor Polymorphisms Are Related To Body Mass Index In A Turkish Population, Uzay Görmüş, Özlem Ti̇mi̇rci̇ Kahraman, Bahar Toptaş, Turgay İsbi̇r, Çavlan Çi̇ftçi̇, Hasan Hakan Berkkan, Altay Burak Dalan, Muti̇a Canan Karatay
Turkish Journal of Medical Sciences
Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal was to investigate the association between leptin levels and leptin receptor polymorphisms in a Turkish population. Materials and methods: The sample pool of this study consisted of 202 subjects. G2548A variant in the promoter region of the leptin gene and Q223R polymorphism of the leptin receptor gene were evaluated by using PCR-RFLP. Leptin levels were determined by ELISA. Results: Leptin levels were significantly higher …
The Relation Between Helicobacter Pylori And Ulcerative Colitis, Sedat Caner, Aki̇f Altinbaş, Yusuf Yeşi̇l, Yavuz Beyazit, Bariş Yilmaz, Osman Yüksel
The Relation Between Helicobacter Pylori And Ulcerative Colitis, Sedat Caner, Aki̇f Altinbaş, Yusuf Yeşi̇l, Yavuz Beyazit, Bariş Yilmaz, Osman Yüksel
Turkish Journal of Medical Sciences
Besides some genetic explanations of the native course of ulcerative colitis (UC), the most attributable factors are pathogenic bacterial agents. There are some conflicting data about the relationship between Helicobacter pylori and the rate of UC in the literature. Therefore, we aimed to investigate the rate of H. pylori in UC patients. Materials and methods: Forty-nine individuals diagnosed with UC who had undergone upper gastrointestinal tract endoscopy for different reasons were included in the study. The presence of H. pylori in the stomach was checked by histopathological examination. Results: H. pylori positivity was present in 57.1% of patients with UC. …
The Correlation Of Echo Findings Of Right Cardiac Pathologies With Bnp, Uric Acid, And Crp In Osas, Ömer Araz, Eli̇f Yilmazel Uçar, Hüsnü Deği̇rmenci̇, Di̇dem Pulur, Hami̇t Acemoğlu, Ednan Bayram, Fuat Gündoğdu, Meti̇n Akgün
The Correlation Of Echo Findings Of Right Cardiac Pathologies With Bnp, Uric Acid, And Crp In Osas, Ömer Araz, Eli̇f Yilmazel Uçar, Hüsnü Deği̇rmenci̇, Di̇dem Pulur, Hami̇t Acemoğlu, Ednan Bayram, Fuat Gündoğdu, Meti̇n Akgün
Turkish Journal of Medical Sciences
Right cardiac pathologies develop in patients with obstructive sleep apnea syndrome (OSAS) and in most patients there are no symptoms in the early stages of right cardiac disorders. We aimed to evaluate a possible relationship between B-type natriuretic peptide (BNP), blood uric acid, C-reactive protein (CRP), and the right cardiac pathologies in patients with OSAS, and the role of these parameters in the management of patients with OSAS. Materials and methods: A total of 98 subjects, 31 (31.6%) controls and 67 (68.4%) with OSAS, were included in the study. All the subjects underwent polysomnography, and standard and tissue Doppler echocardiography …
Polymorphisms In Mmp-2 And Timp-2 In Turkish Patients With Prostate Cancer, Kürşat Oğuz Yaykaşli, Muhammet Ali̇ Kayikçi, Nesi̇be Yamak, Hati̇ce Soğuktaş, Selma Düzenli̇, Ali̇ Osman Arslan, Ahmet Meti̇n, Ertuğrul Kaya, Ömer Faruk Hati̇poğlu
Polymorphisms In Mmp-2 And Timp-2 In Turkish Patients With Prostate Cancer, Kürşat Oğuz Yaykaşli, Muhammet Ali̇ Kayikçi, Nesi̇be Yamak, Hati̇ce Soğuktaş, Selma Düzenli̇, Ali̇ Osman Arslan, Ahmet Meti̇n, Ertuğrul Kaya, Ömer Faruk Hati̇poğlu
Turkish Journal of Medical Sciences
Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the remodeling of the extracellular matrix (ECM). The imbalance between MMPs and TIMPs may lead to an emergence of pathological processes such as cancer. In this study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) polymorphisms and prostate cancer in the Turkish population was investigated. Materials and methods: Sixty-one prostate cancer patients and 46 healthy subjects were included in the study. DNA was isolated from 2 …
Does Lymph Node Involvement Affect The Patterns Of Recurrence In Stage Ib Cervical Cancer?, Işin Üreyen, Ülkü Aksoy, Betül Dündar, Ömer Lütfi̇ Tapisiz, Mustafa Alper Karalök, Ahmet Taner Turan, Nuretti̇n Boran, Hakki Gökhan Tulunay
Does Lymph Node Involvement Affect The Patterns Of Recurrence In Stage Ib Cervical Cancer?, Işin Üreyen, Ülkü Aksoy, Betül Dündar, Ömer Lütfi̇ Tapisiz, Mustafa Alper Karalök, Ahmet Taner Turan, Nuretti̇n Boran, Hakki Gökhan Tulunay
Turkish Journal of Medical Sciences
To investigate the variations in the recurrence patterns of stage IB cervical cancer according to lymph node involvement. Materials and methods: We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007. Results: Among the patients in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 patients developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence …
A Case--Ontrol Study Of The Factors Affecting Male Infertility, Mohammad Mahboubi, Fezollah Foroughi, Fariba Ghahramani, Hanieh Shahandeh, Sahar Moradi, Tooraj Shirzadian
A Case--Ontrol Study Of The Factors Affecting Male Infertility, Mohammad Mahboubi, Fezollah Foroughi, Fariba Ghahramani, Hanieh Shahandeh, Sahar Moradi, Tooraj Shirzadian
Turkish Journal of Medical Sciences
Infertility is defined as the inability to conceive after at least 1 year of unprotected intercourse. In about one third of infertile couples, a male factor is the primary problem. Thus, the present study aimed to determine the most common risk factors for male infertility in Iranian men. Materials and methods: This case-control study included 268 men attending an infertility clinic in Shiraz, Iran. In this study, 161 fertile men were compared with 108 infertile ones regarding risk factors such as smoking habits, drug consumption, hernia, varicocele, job, and BMI. The data were analyzed using logistic regression analysis and t-test. …
Surgery For Intractable Temporal Lobe Epilepsy: Experience Of A Single Institution, Gökhan Kurt, Mehmet Tönge, Emrah Çelti̇kçi̇, İrem Çapraz, Ayşe Serdaroğlu, Erhan Bi̇li̇r
Surgery For Intractable Temporal Lobe Epilepsy: Experience Of A Single Institution, Gökhan Kurt, Mehmet Tönge, Emrah Çelti̇kçi̇, İrem Çapraz, Ayşe Serdaroğlu, Erhan Bi̇li̇r
Turkish Journal of Medical Sciences
In the treatment of epilepsy, encouraging results have been achieved with surgical treatment, especially for temporal lobe epilepsy (TLE). Drug resistance must be diagnosed as early as possible, because the ensuing seizures can be eliminated surgically via temporal lobe surgery in a high percentage (70%-90%) of patients. In this study we share our experience, in a single institution, of surgical treatment of intractable TLE. Materials and methods: Between March 2006 and November 2010 we performed 127 corticoamygdalohippocampectomy (CAH) procedures. All CAH surgical procedures were done as described by Niemeyer's technique. Resection lengths were 4-4.5 cm from the temporal pole. Results: …
Expression And Clinical Implications Of P53, P63, And P73 Protein In Malignant Tumor Of The Parotid Gland, Mei Yong, Ling Yang, Qimuge Suyila, Wenyan Han, Hongwei Yuan, Cheng Zhao, Xiulan Su
Expression And Clinical Implications Of P53, P63, And P73 Protein In Malignant Tumor Of The Parotid Gland, Mei Yong, Ling Yang, Qimuge Suyila, Wenyan Han, Hongwei Yuan, Cheng Zhao, Xiulan Su
Turkish Journal of Medical Sciences
To investigate the expression of P53, P63, and P73 proteins in malignant parotid gland tumors and adjacent nonneoplastic tissues and the association between the 3 proteins and their clinical characteristics. Materials and methods: A total of 40 pairs of paraffin-embedded malignant parotid gland tumors and adjacent nonneoplastic tissues were collected. We detected P53, P63, and P73 protein expression by immunohistochemistry. Statistical analysis was performed by using the chi-square test. Results: P53, P63, and P73 protein expression in malignant parotid gland tumors was higher than their expression in adjacent nonneoplastic tissue (P = 0.030, 0.001, and 0.001, respectively). Expression of P53, …
Comparative Study Of Photodynamic Therapy Monotherapy Versus Triple Management In Age-Related Macular Degeneration, Ahmet Seli̇m, Ni̇lüfer Koçak, Hüseyi̇n Aslankara, Süleyman Kaynak
Comparative Study Of Photodynamic Therapy Monotherapy Versus Triple Management In Age-Related Macular Degeneration, Ahmet Seli̇m, Ni̇lüfer Koçak, Hüseyi̇n Aslankara, Süleyman Kaynak
Turkish Journal of Medical Sciences
To compare the effectiveness of photodynamic therapy (PDT) and PDT combined with intravitreal triamcinolone (IVTA) and vascular endothelial growth factor inhibition (anti-VEGF) in age-related macular degeneration (AMD). Materials and methods: Eighty eyes of 80 patients diagnosed with choroidal neovascularization (CNV) caused by AMD were included in the study. PDT was carried out on 40 eyes in group I, and PDT combined with 4 mg IVTA and anti-VEGF (1.25 mg bevacizumab in 20 eyes, 0.3 mg pegaptanib sodium in 20 eyes) was carried out in group II. The primary efficacy endpoint was the mean change from baseline visual acuity at month …