Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- COVID-19 (110)
- Children (97)
- Oxidative stress (90)
- Inflammation (65)
- Rat (62)
-
- Mortality (59)
- Treatment (57)
- Turkey (57)
- Breast cancer (51)
- Prognosis (51)
- Pregnancy (49)
- Apoptosis (47)
- Prevalence (47)
- Magnetic resonance imaging (46)
- Obesity (46)
- Diabetes mellitus (37)
- Quality of life (36)
- Risk factors (36)
- Diagnosis (34)
- Nitric oxide (32)
- Ultrasonography (32)
- Rheumatoid arthritis (31)
- Epidemiology (30)
- Asthma (29)
- Hypertension (29)
- Reliability (29)
- Child (28)
- Validity (28)
- Depression (26)
- Diabetes (26)
- Publication Year
Articles 2731 - 2760 of 4871
Full-Text Articles in Medicine and Health Sciences
The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan
The Relation Between Oxidative Stress Parameters, Ischemic Stroke,And Hemorrhagic Stroke, Ferhat İçme, Özcan Erel, Akkan Avci̇, Sali̇m Satar, Müge Gülen, Selen Acehan
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to investigate the significance of oxidative stress parameters in the pathogenesis of ischemic stroke and hemorrhagic stroke and to investigate their effects on stroke severity using the National Institutes of Health Stroke Scale (NIHSS). Materials and methods: A total of 92 patients, including 74 with ischemic stroke and 18 with hemorrhagic stroke, and 75 volunteers were enrolled in the study. Total oxidant status (TOS), total antioxidant status (TAS), paraoxonase, stimulating paraoxonase, arylesterase, and thiol levels were measured in both the patient and volunteer groups. NIHSS and oxidative stress index (OSI) scores were calculated. …
Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz
Investigation Of The Effect Of Changes In Muscle Strength In Gestational Ageupon Fear Of Falling And Quality Of Life, Emrah Atay, Fatma Başalan İz
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is the investigation of the effect of changes in muscle strength in gestational age upon fear of falling and quality of life. Materials and methods: This longitudinal, descriptive study included a sample of 37 pregnant women who volunteered to participate. The research data were collected at 20 and 32 weeks of gestation. Data collection instruments included a newly developed questionnaire form, the Tinetti Falls Efficacy Scale, a visual analog scale, and the Turkish language version of the WHO Quality of Life Scale. Upper body flexibility was measured by the back scratch test, while muscle …
Risk Factors And Maximum Standardized Uptake Values Within Lymph Nodes Of Anthracosis Diagnosed By Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Ni̇lgün Yilmaz Demi̇rci̇, İbrahi̇m Onur Alici, Aydin Yilmaz, Funda Demi̇rağ, Ebru Tatci, Yurdanur Erdoğan
Risk Factors And Maximum Standardized Uptake Values Within Lymph Nodes Of Anthracosis Diagnosed By Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Ni̇lgün Yilmaz Demi̇rci̇, İbrahi̇m Onur Alici, Aydin Yilmaz, Funda Demi̇rağ, Ebru Tatci, Yurdanur Erdoğan
Turkish Journal of Medical Sciences
Background/aim: Enlarged mediastinal lymph nodes can result from serious etiologies including granulomatous disease, neoplasia, etc., and a rare condition called anthracosis . The aim of this study was to determine the incidence of risk factors and the uptake values within the anthracotic lymph nodes. Materials and methods: 106 patients who underwent endobronchial ultrasound transbronchial needle aspiration and were diagnosed as having anthracosis were analyzed retrospectively. Patients with positive confirmation by surgical biopsies or a 1-year follow-up period were enrolled. Results: 201 lymph nodes were sampled from 106 patients. Subcarinal and interlobar lymph nodes were the most commonly affected stations (36.8% …
Cognitive Problems Related To Vertebro-Basilar Circulation, Abdulkadi̇r Koçer
Cognitive Problems Related To Vertebro-Basilar Circulation, Abdulkadi̇r Koçer
Turkish Journal of Medical Sciences
Neurodegenerative disorders are characterized by decreased regional cerebral blood flow. Supporting this concept, both cognitive training exercises and physical activity promote blood flow increase and correlate with healthy cognitive aging. The terminal branches of the posterior circulation supply blood to areas of the brain, such as the thalamus, hippocampus, occipital lobe, and cerebellum, involved with important intellectual functions, particularly recent memory, visual-spatial functioning, and visuomotor adaptations. Amnesia and visual agnosia may be a complication of not only posterior circulation infarctions but also vertebrobasilar insufficiency (VBI) without accompanying structural infarcts. The cognitive impairment may be a manifestation of transient attacks and …
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is one of the areas of interest in studies on the pathogenesis of AD. It is a process of self-digestion that is thought to be a response to stressors and allows cells to adapt to environmental changes. There is accumulating evidence showing an association between autophagy …
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Nutritional Issues In Dementia Patients, Mustafa Kemal Kiliç, Fati̇h Sümer, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Dementia is an inevitable disease of aging, leading not only to diminished cognitive ability but also behavioral changes, malnutrition, pressure sores, and infections. Acknowledging common problems and their solutions is essential for any health service worker who deals with demented geriatric patients.
A Comparison Of Hair And Serum Trace Elements In Patients With Alzheimer Disease And Healthy Participants, Emi̇ne Rabi̇a Koç, Ati̇lla İlhan, Zübeyde Aytürk, Burcu Acar, Mukaddes Gürler, Aynur Altuntaş, Mustafa Karapi̇rli̇, Abdurrahman Sai̇d Bodur
A Comparison Of Hair And Serum Trace Elements In Patients With Alzheimer Disease And Healthy Participants, Emi̇ne Rabi̇a Koç, Ati̇lla İlhan, Zübeyde Aytürk, Burcu Acar, Mukaddes Gürler, Aynur Altuntaş, Mustafa Karapi̇rli̇, Abdurrahman Sai̇d Bodur
Turkish Journal of Medical Sciences
Background/aim: To determine whether there was a difference between serum and hair trace elements' concentrations in patients with Alzheimer disease (AD) and healthy participants. Materials and methods: Hair and serum copper, selenium, zinc, magnesium, manganese, and iron levels were measured by inductively coupled plasma-mass spectrometry in patients with AD and healthy participants, and the obtained results were statistically compared. Results: The mean hair selenium and zinc levels of patients with AD were significantly lower than the levels found for control participants (P < 0.05). Patients with AD had significantly higher mean hair copper and manganese levels than the controls. There were no significant differences between AD patients and controls with respect to the hair iron and magnesium levels (P > 0.05). Hair and serum trace element (copper, selenium, zinc, magnesium, manganese, and iron) levels in patients with AD …
Forensic Medicine Evaluation Of Alzheimer Patients: A Series From Ankara, Turkey, Mehmet Cavlak, Ramazan Akçan, Ali̇ Riza Tümer, Aysun Balseven Odabaşi, Aykut Lale, Mahmut Şeri̇f Yildirim, Eyup Ruşen Heybet
Forensic Medicine Evaluation Of Alzheimer Patients: A Series From Ankara, Turkey, Mehmet Cavlak, Ramazan Akçan, Ali̇ Riza Tümer, Aysun Balseven Odabaşi, Aykut Lale, Mahmut Şeri̇f Yildirim, Eyup Ruşen Heybet
Turkish Journal of Medical Sciences
Background/aim: Pathophysiological changes due to Alzheimer disease and increasing age might result in situations requiring forensic evaluation in the elderly. Judicial bodies might need forensic evaluation of trauma and the decision-making capacity of Alzheimer patients. This study aimed to determine the demographic and clinical characteristics of Alzheimer patients seen for forensic evaluation. Materials and methods: Forensic records issued by the Department of Forensic Medicine of Hacettepe University in 2012 and 2013 were investigated. Patients with Alzheimer disease were included in the study and were analyzed in terms of age, sex, reason for application, comorbid medical conditions, occupation, and place and …
Vitamin D Status And Its Association With Gradual Decline In Cognitive Function, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Özgür Kara, Burçi̇n Halaçli, Sezgi̇n Etgül, Muhammet Cemal Kizilarslanoğlu, Burcu Balam Yavuz, Münevver Özcan, Meltem Gülhan Hali̇l, Eylem Şahi̇n Cankurtaran, Mustafa Cankurtaran, Servet Arioğul
Vitamin D Status And Its Association With Gradual Decline In Cognitive Function, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Özgür Kara, Burçi̇n Halaçli, Sezgi̇n Etgül, Muhammet Cemal Kizilarslanoğlu, Burcu Balam Yavuz, Münevver Özcan, Meltem Gülhan Hali̇l, Eylem Şahi̇n Cankurtaran, Mustafa Cankurtaran, Servet Arioğul
Turkish Journal of Medical Sciences
Background/aim: To compare plasma vitamin D concentrations among patients with normal cognitive function (control group), mild cognitive impairment (MCI), and Alzheimer disease (AD). Materials and methods: In total, 158 patients with AD, 228 patients with MCI, and 603 control subjects were included. Plasma levels of 25-hydroxyvitamin D were measured after comprehensive geriatric assessment and compared among groups. SPSS 15.0 was used for statistical analysis. Results: Mean levels of 25-hydroxyvitamin D were significantly different among the 3 groups of AD patients, MCI patients, and controls (P < 0.001). Post hoc analysis revealed that the levels were significantly lower in the MCI group than the control group (P = 0.002) and significantly lower in the AD group than the control group (P = 0.003). Multivariate analysis showed that age (OR: 1.070, 95% CI: 1.025-1.116, P = 0.002), instrumental activities of daily living score (OR: 0.920, 95% CI: 0.850-0.995, P = 0.037), 25-hydroxyvitamin D level (OR: 0.959, 95% CI: 0.932-0.987, P = 0.004), and diabetes mellitus (OR: 2.476, 95% CI: 1.153-5.319, P = 0.020) were factors independently associated with AD. Conclusion: This study demonstrated that there is a correlation between plasma 25-hydroxyvitamin D levels and cognitive functions.
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Alzheimer Disease, Inflammation, And Novel Inflammatory Marker: Resistin, Muhammet Cemal Kizilarslanoğlu, Özgür Kara, Yusuf Yeşi̇l, Mehmet Emi̇n Kuyumcu, Zeynel Abi̇di̇n Öztürk, Mustafa Cankurtaran, Samed Rahatli, Nagehan Pakaşti̇çali, Esat Çinar, Meltem Gülhan Hali̇l, Burçi̇n Şener, Eylem Şahi̇n Cankurtaran, Servet Arioğul
Turkish Journal of Medical Sciences
Background/aim: Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. A growing amount of evidence indicates that resistin has hallmark regulatory functions such as inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers such as hs-CRP and TNF-α. Materials and methods: In this cross-sectional study, 38 AD patients and 32 control subjects with normal cognitive function aged 65 years and over were included. The diagnosis of AD was made according to DSM-IV …
Malnutrition Is Associated With Dementia Severity And Geriatricsyndromes In Patients With Alzheimer Disease, Demet Yildiz, Ni̇lüfer Büyükkoyuncu Pekel, Ahmet Kasim Kiliç, Eli̇f Nalan Tolgay, Fati̇h Tufan
Malnutrition Is Associated With Dementia Severity And Geriatricsyndromes In Patients With Alzheimer Disease, Demet Yildiz, Ni̇lüfer Büyükkoyuncu Pekel, Ahmet Kasim Kiliç, Eli̇f Nalan Tolgay, Fati̇h Tufan
Turkish Journal of Medical Sciences
Background/aim: Malnutrition is associated with increased morbidity and mortality in patients with Alzheimer disease (AD). In this study, we aimed to screen for malnutrition and geriatric syndromes and seek their associations in patients with AD. Materials and methods: The Mini Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), Katz Activities of Daily Living (ADL), and Lawton Instrumental Activities of Daily Living (IADL) tests were applied. Mean daily oral fluid intake was assessed according to patients' and relatives' declarations. Results: Seventy-six patients with a mean age of 79 ± 7.4 years were included. Most of the patients had mild or moderate …
Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş
Plasma 8-Isopgf2? And Serum Melatonin Levels In Patients With Minimal Cognitive Impairment And Alzheimer Disease, Fevzi̇ye Burcu Şi̇ri̇n, Duygu Kumbul Doğuç, Hüseyi̇n Vural, İbrahi̇m Eren, İkbal İnanli, Recep Sütcü, Namik Deli̇baş
Turkish Journal of Medical Sciences
Background/aim: F2α-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2α levels were measured by enzyme immunoassay method. Results: Significant differences were observed in …
The Reliability And Validity Of The Turkish Version Of Theneuropsychiatric Inventory-Clinician, Eylem Şahi̇n Cankurtaran, Mustafa Danişman, Hasan Tutar, Semra Ulusoy Kaymak
The Reliability And Validity Of The Turkish Version Of Theneuropsychiatric Inventory-Clinician, Eylem Şahi̇n Cankurtaran, Mustafa Danişman, Hasan Tutar, Semra Ulusoy Kaymak
Turkish Journal of Medical Sciences
Background/aim: The Neuropsychiatric Inventory-Clinician (NPI-C) scale is one of the best-known scales for evaluating the behavioral and psychological symptoms of dementia. This study aimed to assess the reliability and validity of the Turkish version of the NPI-C scale in patients with Alzheimer disease (AD). Materials and methods: The NPI-C scale was administered to 125 patients with AD. For reliability, both Cronbach's α and interrater reliability were analyzed. The Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) scale was applied for validity and, in addition, the Mini Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL) scale, and Disability Assessment of Dementia …
Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇
Evaluation Of Retinal Nerve Fiber Layer Thickness In Alzheimer Disease Usingspectral-Domain Optical Coherence Tomography, Ali̇me Güneş, Seden Demi̇rci̇, Levent Tök, Özlem Tök, Serpi̇l Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls. Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and education-matched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results: The average RNFL thickness was 84 …
Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök
Is Alzheimer Disease Related To Age-Related Macular Degeneration?, Seden Demi̇rci̇, Ali̇me Güneş, Kadi̇r Demi̇rci̇, Serpi̇l Demi̇rci̇, Levent Tök, Özlem Tök
Turkish Journal of Medical Sciences
Background/aim: To compare the cognitive functions and define the frequency of Alzheimer disease (AD) between participants with and without age-related macular degeneration (AMD). Materials and methods: Fifty-nine patients with late-stage AMD (74.3 ± 7.3 years) and 49 age-, sex-, and education-matched control subjects were compared for the presence of AD according to the guidelines of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Detailed neuropsychological tests were performed for all subjects. Results: Neuropsychiatric tests scores were lower in the AMD group than the control group. The frequency of AD …
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
The Effects And Interactions Of Apoe And Aph-1a Polymorphisms In Alzheimer Disease, Burcu Acar Çi̇nleti̇, Ni̇lgül Yardimci, Zübeyde Aytürk, Ati̇lla İlhan, Gülhan Kaya, Muradi̇ye Acar, Emi̇ne Rabi̇a Koç, Esra Gündüz, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid β-peptide, which is derived from β-amyloid precursor protein through degradation by β-secretase and γ-secretase complexes. One of the major components of γ-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the γ-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies …
The Connection Between Mci And Alzheimer Disease: Neurocognitive Clues, Kübra Batum, Ni̇lgün Çinar, Şevki̇ Şahi̇n, Mi̇raç Ayşen Çakmak, Si̇bel Karşidağ
The Connection Between Mci And Alzheimer Disease: Neurocognitive Clues, Kübra Batum, Ni̇lgün Çinar, Şevki̇ Şahi̇n, Mi̇raç Ayşen Çakmak, Si̇bel Karşidağ
Turkish Journal of Medical Sciences
Background/aim: Mild cognitive impairment (MCI) is defined as a pathological stage between 'healthy aging' and 'dementia'. In this study, cases of MCI were compared with early-stage Alzheimer disease (AD) and age-related cognitive decline (ARCD) in terms of cognitive profiles in order to find a connection between MCI and AD. Materials and methods: Patients who were comparable in terms of age and sex and who met the criteria of MCI, ARCD, or early-stage AD were included in the study retrospectively. Wechsler memory scale, executive function, visuospatial, language, and memory tests were applied to all subjects. Additionally, all patients completed a mini-mental …
Effect Of Capparis Spinosa L. On Cognitive Impairment Induced By D-Galactosein Mice Via Inhibition Of Oxidative Stress, Nergi̇z Hacer Turgut, Haki̇ Kara, Emre Arslanbaş, Derya Güli̇z Mert, Bektaş Tepe, Hüseyi̇n Güngör
Effect Of Capparis Spinosa L. On Cognitive Impairment Induced By D-Galactosein Mice Via Inhibition Of Oxidative Stress, Nergi̇z Hacer Turgut, Haki̇ Kara, Emre Arslanbaş, Derya Güli̇z Mert, Bektaş Tepe, Hüseyi̇n Güngör
Turkish Journal of Medical Sciences
Background/aim: To determine the phenolic acid levels and DNA damage protection potential of Capparis spinosa L. seed extract and to investigate the effect of the extract on cognitive impairment and oxidative stress in an Alzheimer disease mice model. Materials and methods: Thirty BALB/c mice divided into 5 groups (control??, D-galactose, D-galactose + C. spinosa 50, D-galactose + C. spinosa 100, D-galactose + C. spinosa 200) were used. Mice were administered an injection of D-galactose (100 mg/kg, subcutaneous) and orally administered C. spinosa (50, 100, or 200 mg/kg) daily for 8 weeks. Results: Syringic acid was detected and the total amount …
Molecular Docking And Ex Vivo And In Vitro Anticholinesterase Activity Studies Ofsalvia Sp. And Highlighted Rosmarinic Acid, Lütfi̇ye Ömür Demi̇rezer, Peri̇han Gürbüz, Emi̇ne Peli̇n Keli̇cen Uğur, Mi̇ne Bodur, Nadi̇re Özenver, Ayşe Uz, Zühal Güvenalp
Molecular Docking And Ex Vivo And In Vitro Anticholinesterase Activity Studies Ofsalvia Sp. And Highlighted Rosmarinic Acid, Lütfi̇ye Ömür Demi̇rezer, Peri̇han Gürbüz, Emi̇ne Peli̇n Keli̇cen Uğur, Mi̇ne Bodur, Nadi̇re Özenver, Ayşe Uz, Zühal Güvenalp
Turkish Journal of Medical Sciences
Background/aim: To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD). Materials and methods: The AChE inhibitory activity of different extracts from Salvia trichoclada, Salvia verticillata, and Salvia fruticosa was determined by the Ellman and isolated guinea pig ileum methods, and the antioxidant capacity was determined with DPPH. The AChE inhibitory activity of the major molecule rosmarinic acid was determined by in silico docking and isolated guinea pig ileum methods. Results: The methanol extract of Salvia trichoclada showed the highest inhibition …
Impaired Cognitive Performance And Hippocampal Atrophy In Parkinson Disease, Demet Yildiz, Sevda Erer, Mehmet Zari̇foğlu, Bahatti̇n Hakyemez, Mustafa Bakar, Necdet Karli, Zeynep Ni̇gar Varlibaş, Fati̇h Tufan
Impaired Cognitive Performance And Hippocampal Atrophy In Parkinson Disease, Demet Yildiz, Sevda Erer, Mehmet Zari̇foğlu, Bahatti̇n Hakyemez, Mustafa Bakar, Necdet Karli, Zeynep Ni̇gar Varlibaş, Fati̇h Tufan
Turkish Journal of Medical Sciences
Background/aim: Dementia is common in Parkinson disease (PD). Since magnetic resonance imaging has been used, hippocampal atrophy has been shown in PD patients with or without dementia. In this study we sought the correlation of cognitive decline with bilateral hippocampal volume in PD patients. Materials and methods: Thirty-three patients with diagnosis of idiopathic PD and 16 healthy subjects were included in this study. PD patients were divided into two groups as normal cognitive function and mild cognitive impairment (MCI). The Mini-Mental State Examination and detailed cognitive assessment tests were performed for all patients for cognitive analyses. Depression was excluded by …
Familial Mediterranean Fever In Children From The Aegean Region Of Turkey:Gene Mutation Frequencies And Phenotype?Genotype Correlation, Ebru Yilmaz, Ni̇da Di̇nçel, Betül Sözeri̇, Kadri̇ye Özdemi̇r, İpek Kaplan Bulut, Afig Berdeli, Makbule Sevgi̇ Mi̇r
Familial Mediterranean Fever In Children From The Aegean Region Of Turkey:Gene Mutation Frequencies And Phenotype?Genotype Correlation, Ebru Yilmaz, Ni̇da Di̇nçel, Betül Sözeri̇, Kadri̇ye Özdemi̇r, İpek Kaplan Bulut, Afig Berdeli, Makbule Sevgi̇ Mi̇r
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF) is diagnosed by fever episodes with sterile peritonitis, arthritis, pleurisy, and erysipelas-like erythema. The relationship between phenotype and genotype in FMF has not been adequately explained. The aim of this study was to characterize the phenotype and genotype correlation in FMF. Materials and methods: Clinical diagnosis of FMF was conducted according to the Tel Hashomer criteria. Pras scoring was used to determine clinical severity. FMF strip assay analysis was used, and the hotspot regions were observed with PCR amplification and automatic DNA sequence analysis method. Results: We showed commonly seen mutations (most frequently M694V) in …
Assessment Of Bloodstream Infections And Risk Factors In An Intensive Care Unit, Aynur Süner, İlkay Karaoğlan, Ayşe Özlem Mete, Mustafa Namiduru, Vuslat Boşnak, İbrahi̇m Baydar
Assessment Of Bloodstream Infections And Risk Factors In An Intensive Care Unit, Aynur Süner, İlkay Karaoğlan, Ayşe Özlem Mete, Mustafa Namiduru, Vuslat Boşnak, İbrahi̇m Baydar
Turkish Journal of Medical Sciences
Background/aim: Nosocomial bloodstream infection (BSI) increases mortality rates, duration of stay in hospital, and treatment costs. This study was conducted to determine the rate and the risk factors of BSIs among intensive care unit patients. Materials and methods: Sixty-four patients with BSIs (patient group) and 79 patients without a nosocomial infection (control group) were enrolled in the study. Centers for Disease Control and Prevention criteria were used for diagnosing BSIs. Potential risk factors were evaluated by multivariate logistic regression model. Results: The BSI development rate was 15.7% (64/407), with an incidence rate of 18.2/1000 patient days. Distribution of pathogens among …
Restless Legs Syndrome In Multiple Sclerosis, Mi̇ne Hayri̇ye Sorgun, Zeri̇n Aksun, Yahya Burak Atalay, Canan Yücesan
Restless Legs Syndrome In Multiple Sclerosis, Mi̇ne Hayri̇ye Sorgun, Zeri̇n Aksun, Yahya Burak Atalay, Canan Yücesan
Turkish Journal of Medical Sciences
Background/aim: There have been conflicting results in the literature regarding the relationship between functional system involvement, the expanded disability status scale (EDSS), and the presence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS). Materials and methods: Ninety-one patients with MS and 40 patients in a control group (headache, essential tremor, and benign positional paroxysmal vertigo) were studied. The patients underwent a complete neurological examination and Kurtzke functional system scores were calculated. In order to assess the temporal relation between the onset of RLS and MS, a semistructured interview guided by a questionnaire about RLS was applied to …
Mirna-Mediated Regulation Of Heat Shock Proteins In Human Ejaculated Spermatozoa, Tang Wenhao, Liu De-Feng, Hong Kai, Zhao Lian-Ming, Mao Jia-Ming, Zhuang Xin-Jie, Ma Lu-Lin, Jiang Hui
Mirna-Mediated Regulation Of Heat Shock Proteins In Human Ejaculated Spermatozoa, Tang Wenhao, Liu De-Feng, Hong Kai, Zhao Lian-Ming, Mao Jia-Ming, Zhuang Xin-Jie, Ma Lu-Lin, Jiang Hui
Turkish Journal of Medical Sciences
Background/aim: Heat shock proteins (HSPs) are expressed in human spermatozoa and play a role in sperm function. MicroRNAs (miRNAs) regulate gene expression, and the possible involvement of miRNAs in the regulation of HSP gene expression in sperm was investigated in this study. Materials and methods: miRNAs differentially expressed in 8 copies of an oligoasthenozoospermic semen group (OA) were identified by comparison with a normal male semen control group (NC) using microarray technology. Potential targets of HSP proteins among the differentially expressed miRNAs were further investigated. Results: HSP40, HSP60, HSP70, and HSP90 were all found to be expressed in human ejaculated …
Osteoprotegerin As A Marker Of Atherosclerosis In Type 1 And Type 2 Diabetic Patients, Çi̇ğdem Alkaç, Burak Alkaç, Feray Akbaş, Hale Aral, Yeşi̇m Karagöz, Esma Güldal Altunoğlu
Osteoprotegerin As A Marker Of Atherosclerosis In Type 1 And Type 2 Diabetic Patients, Çi̇ğdem Alkaç, Burak Alkaç, Feray Akbaş, Hale Aral, Yeşi̇m Karagöz, Esma Güldal Altunoğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the availability of osteoprotegerin (OPG) as a marker of atherosclerosis and compare serum OPG levels with ankle-brachial index (ABI) in diabetic patients. Materials and methods: A total of 31 type 1 and 31 type 2 diabetic patients without macrovascular complications and 20 healthy volunteers were included. Serum OPG levels and ABI were measured. Results: The duration of diabetes was significantly higher in type 1 diabetics than in type 2, although there was no significant difference between mean HbA1c levels. There was a weak and inverse correlation between OPG and atherosclerosis in …
Hypogastric Artery Ligation For Obstetrical Hemorrhage: Clinical Experiencein A Tertiary Care Center, Çağlar Yildiz, Özlem Bozoklu Akkar, Savaş Karakuş, Ali̇ Çeti̇n, Ali̇ Yanik
Hypogastric Artery Ligation For Obstetrical Hemorrhage: Clinical Experiencein A Tertiary Care Center, Çağlar Yildiz, Özlem Bozoklu Akkar, Savaş Karakuş, Ali̇ Çeti̇n, Ali̇ Yanik
Turkish Journal of Medical Sciences
Background/aim: Several authorities advocate the use of hypogastric artery ligation (HAL) in the treatment of cases of obstetrical hemorrhage related to uterine atony or placenta accreta. We assessed the morbidity and mortality of patients who underwent HAL as a component of emergency procedures to control life-threatening uterine bleeding in a tertiary-care university hospital. Materials and methods: In this retrospective study, the clinical data of 24 eligible patients who underwent HAL between 2010 and 2013 in a university hospital to prevent or control severe uterine bleeding were collected and analyzed with regard to intraoperative and postoperative findings. Results: In the study …
Applicability Of Xpert Mtb/Rif Assay For Routine Diagnosis Of Tuberculosis: A Four-Year Single-Center Experience, Cem Çeli̇k, Mustafa Gökhan Gözel, Mustafa Zahi̇r Bakici, Serdar Berk, Sefa Levent Özşahi̇n, Esra Gültürk
Applicability Of Xpert Mtb/Rif Assay For Routine Diagnosis Of Tuberculosis: A Four-Year Single-Center Experience, Cem Çeli̇k, Mustafa Gökhan Gözel, Mustafa Zahi̇r Bakici, Serdar Berk, Sefa Levent Özşahi̇n, Esra Gültürk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to assess the Xpert MTB/RIF assay for diagnosis of the Mycobacterium tuberculosis complex in clinical samples and to compare the results by reference to the diagnostic method, Bactec MGIT 960. Materials and methods: A total of 7407 samples were included from patients not primarily suggesting pulmonary or extrapulmonary tuberculosis (TB), collected from patients required to be screened for TB and excluding TB diagnoses since it was a differential diagnosis. Also included were a total of 411 samples from patients primarily suggesting pulmonary or extrapulmonary TB. Results: In the first group, 152 of 7407 …
Factors Affecting Daily Instrumental Activities Of The Elderly, Ayfer Şahi̇n, Oğuz Teki̇n, Sevsen Cebeci̇, Bünyami̇n Işik, Adem Özkara, Rabi̇a Kahveci̇, Meti̇n Canbal, Şeyda Kunt, İrfan Şencan
Factors Affecting Daily Instrumental Activities Of The Elderly, Ayfer Şahi̇n, Oğuz Teki̇n, Sevsen Cebeci̇, Bünyami̇n Işik, Adem Özkara, Rabi̇a Kahveci̇, Meti̇n Canbal, Şeyda Kunt, İrfan Şencan
Turkish Journal of Medical Sciences
Background/aim: In order to determine elderly people's capabilities in daily activities, we evaluated the factors that may affect their daily instrumental activities. Materials and methods: We performed an observational, analytical, and cross-sectional study on 101 patients above 60 years of age in 2008 and 2009. We applied the Lawton Instrumental Activity of Daily Living (IADL) scale, the Standardized Mini-Mental State Examination (SMMSE), and the Geriatric Depression Scale (GDS) during one-on-one interviews with the patients. Demographic data and disability levels were also recorded. These data were used to evaluate the possible effects of factors on the IADL scale. Results: Statistical analyses …
Histopathological Findings Obtained From Reduction Mammoplasty Specimens, Aynur Albayrak, Çi̇ğdem Güler Mesci̇, Gülnur Güler
Histopathological Findings Obtained From Reduction Mammoplasty Specimens, Aynur Albayrak, Çi̇ğdem Güler Mesci̇, Gülnur Güler
Turkish Journal of Medical Sciences
Background/aim: Reduction mammoplasty is a common surgical procedure. We report the incidence of nonproliferative and proliferative breast lesions in breast reduction specimens from a single institution over a 6-year period. Materials and methods: The histopathology reports of all patients were analyzed. The clinical and histopathological findings of the patients were recorded. Results: Between 2004 and 2010, 106 patients underwent breast reduction. Fifty-six patients (52.8%) had proliferative breast lesions, 84 patients (79.2%) had nonproliferative lesions, 8 patients (7.5%) had columnar cell lesions without atypia, 61 patients (57.5%) had columnar cell lesions with atypia, 5 patients (4.7%) had atypical ductal hyperplasia, and …
Spontaneous Withdrawal In Intermittent Morphine Administration In Rats And Mice: Effect Of Clonidine Coadministration And Sex-Related Differences, Oruc Allahverdi̇yev, Asli Zengi̇n Türkmen, Asi̇ye Nurten, İclal Şehi̇rli̇, Nurhan Engi̇nar
Spontaneous Withdrawal In Intermittent Morphine Administration In Rats And Mice: Effect Of Clonidine Coadministration And Sex-Related Differences, Oruc Allahverdi̇yev, Asli Zengi̇n Türkmen, Asi̇ye Nurten, İclal Şehi̇rli̇, Nurhan Engi̇nar
Turkish Journal of Medical Sciences
Background/aim: Treating animals repeatedly with intermittent and increasing morphine doses has been suggested to allow some withdrawal during each dosing interval, which causes repeated stress. The present study aimed to test this hypothesis and assess sex-related differences in withdrawal signs and their suppression by clonidine. Materials and methods: Male and female rats and mice were administered with increasing doses of morphine twice daily at different dosing intervals. Rats were given clonidine in drinking water (5 μg/mL). Spontaneous and naloxone-precipitated withdrawal signs and novelty-induced grooming were evaluated. Results: Male rats and male and female rats displayed manifestations of morphine withdrawal at …