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Articles 2761 - 2790 of 4871
Full-Text Articles in Medicine and Health Sciences
Investigation Of The Protective Effect Of Erdosteine Against Cyclosporine-Inducedinjury In Rat Liver With Histological And Biochemical Methods, Ahmet Nacar, İhsan Karaboğa, Hamza Mali̇k Okuyan, Nebi̇hat Kaplan Sefi̇l, Emel Nacar, Sedat Motor, Seçki̇n Akküçük, Orhan Veli̇ Özkan
Investigation Of The Protective Effect Of Erdosteine Against Cyclosporine-Inducedinjury In Rat Liver With Histological And Biochemical Methods, Ahmet Nacar, İhsan Karaboğa, Hamza Mali̇k Okuyan, Nebi̇hat Kaplan Sefi̇l, Emel Nacar, Sedat Motor, Seçki̇n Akküçük, Orhan Veli̇ Özkan
Turkish Journal of Medical Sciences
Background/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg-1 day-1 i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg-1 day-1 orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections …
Comparison Of Helmet And Facial Mask During Noninvasiveventilation In Patients With Acute Exacerbation Of Chronic Obstructivepulmonary Disease: A Randomized Controlled Study, Özlem Çakir Gürbüz, Ali̇ Alagöz, Fatma Ulus, Mehtap Tunç, Şazi̇ye Şahi̇n
Comparison Of Helmet And Facial Mask During Noninvasiveventilation In Patients With Acute Exacerbation Of Chronic Obstructivepulmonary Disease: A Randomized Controlled Study, Özlem Çakir Gürbüz, Ali̇ Alagöz, Fatma Ulus, Mehtap Tunç, Şazi̇ye Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Noninvasive mechanical ventilation (NIMV) is an approach to prevent complications in acute respiratory failure. In this study we aimed to compare the efficacy of a full face mask and a helmet in chronic obstructive pulmonary disease (COPD). Materials and methods: Fifty patients were divided randomly into 2 groups as full face mask (Group F) and helmet (Group H). Demographic data, forced expiratory volume at 1 s (FEV1), additional disease, hemodynamic parameters, respiratory rate, APACHE II score, peripheral O2 saturation (SpO2), arterial blood gases (ABG), patient tolerance scale (PTS) score, and fraction of inspired oxygen (FiO2) were recorded. Parameters were …
High-Risk Febrile Neutropenia And Its Management In Childrenwith Solid Tumors And Lymphoma, Doğan Köse, Meli̇ke Emi̇roğlu, Yavuz Köksal
High-Risk Febrile Neutropenia And Its Management In Childrenwith Solid Tumors And Lymphoma, Doğan Köse, Meli̇ke Emi̇roğlu, Yavuz Köksal
Turkish Journal of Medical Sciences
Background/aim: The clinical characteristics and treatment results of febrile neutropenia attacks that occurred in patients with lymphoma and solid tumors were analyzed. Materials and methods: A total of 50 patients with 94 high-risk attacks were evaluated for malignant diseases in this study. Results: The fever etiology was determined as clinical (50%), microbiological (5.31%), clinical-microbiological (5.31%), or unknown (39.3%). A few of the attacks (21.3%) were observed in lymphoma cases and 77.7% were observed in patients with solid tumors. Patients who were in remission had 59.6% of the attacks, and 39.4% occurred in patients not in remission. Among the groups tested, …
Human Semen Quality And Sperm Dna Damage Assessed Bycomet Assay In Clinical Groups, Muhammad Haris Ramzan, Muhammad Ramzan, Muhammad Mumtaz Khan, Faiqah Ramzan, Fazal Wahab, Muhammad Aslam Khan, Musharraf Jillani, Mohsin Shah
Human Semen Quality And Sperm Dna Damage Assessed Bycomet Assay In Clinical Groups, Muhammad Haris Ramzan, Muhammad Ramzan, Muhammad Mumtaz Khan, Faiqah Ramzan, Fazal Wahab, Muhammad Aslam Khan, Musharraf Jillani, Mohsin Shah
Turkish Journal of Medical Sciences
Background/aim: About 10%-15% of couples around the world suffer from infertility. Male infertility is responsible directly or indirectly in ~60% of cases. A deficiency in semen is the most common cause of male infertility. Materials and methods: The study included 180 male subjects aged 18-50 years with 26 fertile and 154 infertile. The infertile subjects were further subdivided according to the WHO guidelines of semen analysis (2010) into different clinical groups. Sperm DNA damage was estimated using a neutral comet assay. Plasma gonadotropin and testosterone levels were measured using a chemiluminescence assay. Results: The results of the study revealed no …
Esophageal Replacement By Hydroxylated Bacterial Cellulose Patch In A Rabbit Model, Changlai Zhu, Fang Liu, Wenbo Qian, Yingjie Wang, Qingsheng You, Tianyi Zhang, Feng Li
Esophageal Replacement By Hydroxylated Bacterial Cellulose Patch In A Rabbit Model, Changlai Zhu, Fang Liu, Wenbo Qian, Yingjie Wang, Qingsheng You, Tianyi Zhang, Feng Li
Turkish Journal of Medical Sciences
Background/aim: To repair esophageal defects by hydroxylated and kombucha -synthesized bacterial cellulose (HKBC) patch in a rabbit model. Materials and methods: Semicircular esophageal defects 1 cm in length of the cervical esophagus were initially created in 18 Japanese big-ear rabbits and then repaired with HKBC patch grafts. The clinical outcomes including survival rate, weight change, food intake, and hematological and radiologic evaluation were observed. After X-ray evaluation, the rabbits were sacrificed sequentially at 1, 3, and 6 months for histopathologic analysis with light microscopy and scanning electron microscopy. Results: Survival rate during the first month was 88.9% (n = 16). …
Urinary Incontinence Among Women Registered With A Family Health Center In The Southeastern Anatolia Region And The Factors Affecting Its Prevalence, Fatma Gözükara, İbrahi̇m Koruk, Burcu Kara
Urinary Incontinence Among Women Registered With A Family Health Center In The Southeastern Anatolia Region And The Factors Affecting Its Prevalence, Fatma Gözükara, İbrahi̇m Koruk, Burcu Kara
Turkish Journal of Medical Sciences
Background/aim: In regions such as Şanlıurfa, Turkey, where the fertility rate is high, suitable health policies to easily and successfully treat urinary incontinence (UI) are needed. This study was conducted to determine the prevalence and risk factors for UI among women in the region. Materials and methods: The participants in this cross-sectional study were selected by using 30 cluster sampling methods. A total of 300 women in the age group of 15-49 years were contacted to participate. Results: The prevalence of UI was 39.3% among women in this sample but only 8.0% actually received treatment. The logistic regression analysis showed …
Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç
Age-Related Macular Degeneration And Alzheimer Disease, Eren Çerman, Muhsi̇n Eraslan, Osman Çeki̇ç
Turkish Journal of Medical Sciences
This review highlight the similarities in the pathogenesis between Alzheimer disease and age-related macular degeneration. All studies published between 1990 and 2014 were reviewed to identify the common pathological pathways. Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …
Test Your Memory-Turkish Version (Tym-Tr): Reliability And Validity Study Of A Cognitive Screening Test, İlknur Mavi̇ş, Belgi̇n Demet Özbabalik Adapinar, Çinar Yeni̇lmez, Ayşe Aydin, Engi̇n Olgun, Cengi̇z Bal
Test Your Memory-Turkish Version (Tym-Tr): Reliability And Validity Study Of A Cognitive Screening Test, İlknur Mavi̇ş, Belgi̇n Demet Özbabalik Adapinar, Çinar Yeni̇lmez, Ayşe Aydin, Engi̇n Olgun, Cengi̇z Bal
Turkish Journal of Medical Sciences
Background/aim: The test your memory (TYM) is reported to be a sensitive cognitive function assessment scale for people with dementia. The aim of the present study was to investigate the reliability and validity of an adapted Turkish version of the TYM (TYM-TR) among Turkish dementia patients. Materials and methods: The TYM-TR was given to 59 patients with dementia aged 60+ and 336 normal controls aged 23-75+. The diagnostic utility of the TYM-TR was compared with that of the mini-mental state examination (MMSE) to validate it. Results: The internal consistency of the TYM-TR was α = 0.85. The test-retest reliability was …
The Prevalence Of Infectious Agents In Patients With Systemic Sclerosis, Hüseyi̇n Bi̇lgi̇n, Hi̇lal Kocabaş, Recep Keşli̇
The Prevalence Of Infectious Agents In Patients With Systemic Sclerosis, Hüseyi̇n Bi̇lgi̇n, Hi̇lal Kocabaş, Recep Keşli̇
Turkish Journal of Medical Sciences
Background/aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular injury, excessive extracellular matrix deposition, and fibrosis in the skin and internal organs. Bacterial and viral infectious agents have been suspected to be contributing factors in the development and progression of the pathologic features of SSc. Materials and methods: In this study, 30 SSc patients who were admitted to the rheumatology unit of the Konya Training and Research Hospital and 30 healthy controls were included. The presence of 9 different antibodies (IgM and IgG) against Helicobacter pylori, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and parvovirus B19 were investigated in sera …
Immunogenicity Of Conserved Cork And Ss-Barrel Domains Of Baumannii Acinetobactin Utilization Protein In An Animal Model, Yaqub Hajiaghatabar Sangroodi, Iraj Rasooli, Shahram Nazarian, Walead Ebrahimizadeh, Fatemeh Sefid
Immunogenicity Of Conserved Cork And Ss-Barrel Domains Of Baumannii Acinetobactin Utilization Protein In An Animal Model, Yaqub Hajiaghatabar Sangroodi, Iraj Rasooli, Shahram Nazarian, Walead Ebrahimizadeh, Fatemeh Sefid
Turkish Journal of Medical Sciences
Background/aim: The uptake of the ferric-acinetobactin complex into the periplasmic space relies on the baumannii acinetobactin utilization (BauA) protein. BauA is composed of cork and the β-barrel domains. We constructed a recombinant protein from conserved antigenic domains of cork and the β-barrel of BauA to evaluate their immunogenic role in an animal model. Materials and methods: The selected bauA domains were amplified from a purified genome of Acinetobacter baumannii ATCC 19606. The domains were then cloned into pET28a and the proteins expressed in E. coli BL21 (DE3) were purified using nickel nitrilotriacetic acid chromatography. Mice and rabbits were immunized with …
Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur
Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur
Turkish Journal of Medical Sciences
Ebola virus disease (EVD) was defined first in 1976. Since then, more than 24 epidemics have been reported from Africa, predominantly with the Zaire species. On 21 March 2014, the current West Africa outbreak was reported by the World Health Organization, the largest one ever recorded. The Congo epidemic was reported in July 2014. It was considered that the two epidemics had unrelated origins with 96.8% identical genomic sequence of the virus. EVD outbreaks occurred in areas with limited resources but it has a potentially global effect due to the possibility of imported infection and the potential misuse of the …
Gastrointestinal System Lesions In Children Due To The Ingestion Of Alkali And Acid Corrosive Substances, Kaan Demi̇rören, Hali̇l Kocamaz, Yaşar Doğan
Gastrointestinal System Lesions In Children Due To The Ingestion Of Alkali And Acid Corrosive Substances, Kaan Demi̇rören, Hali̇l Kocamaz, Yaşar Doğan
Turkish Journal of Medical Sciences
To examine esophageal and gastric lesions in children due to the ingestion of alkali and acid corrosive substances and to emphasize all related complications. Materials and methods: The reports of 103 children who ingested or were suspected to have ingested corrosive substances and who then underwent upper gastrointestinal endoscopic inspections were evaluated retrospectively. Results: Of the patients, the mean age was 41 ± 3.6 months, and 57.3% were male. Vomiting was the most common symptom (44.7%). Eighteen different commercial products were defined as corrosive substances: 59.2% of them were alkali, 39.8% were acids, and 1% had a neutral pH. These …
The Effect Of Total Intravenous Anesthesia On The Postoperative Cognitive Functions Of Young And Elderly Patients After Lumbar Disk Surgery, Gi̇zem İlvan, Hati̇ce Zerri̇n Özköse
The Effect Of Total Intravenous Anesthesia On The Postoperative Cognitive Functions Of Young And Elderly Patients After Lumbar Disk Surgery, Gi̇zem İlvan, Hati̇ce Zerri̇n Özköse
Turkish Journal of Medical Sciences
The negative effects of surgery and anesthesia on cognitive functions and their relationships with many factors are well known. In the present study we aimed to investigate the effect of the total intravenous anesthesia (TIVA) method on the postoperative cognitive functions between young and elderly patients scheduled to undergo lumbar disk surgery. Materials and methods: The TIVA method was applied to 40 patients less than 65 years old (young, Group Y) and => 65 years old (old, Group O), whose Mini Mental State Examination (MMSE) results and serum S-100 beta protein levels were compared preoperatively and postoperatively at the 24th …
The Effects Of Atorvastatin On Antioxidant/Antiinflammatory Propertiesof Hdls In Hypercholesterolemics, Gülşen Akalin Çi̇ftçi̇, İpek Ertorun, Aysen Akalin, İbrahi̇m Özkan Alataş, Ahmet Musmul
The Effects Of Atorvastatin On Antioxidant/Antiinflammatory Propertiesof Hdls In Hypercholesterolemics, Gülşen Akalin Çi̇ftçi̇, İpek Ertorun, Aysen Akalin, İbrahi̇m Özkan Alataş, Ahmet Musmul
Turkish Journal of Medical Sciences
Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in hypercholesterolemic subjects treated with atorvastatin. In this study, we aimed to evaluate effects of atorvastatin treatment on functionality of HDL, oxidative stress, and endothelial functions in hypercholesterolemic subjects. Materials and methods: Thirty patients (20 females, 10 males) aged from 40 to 60 years and diagnosed as hypercholesterolemic were included. Patients were treated with 10 mg/day atorvastatin for 3 months. Markers of endothelial functions, namely asymmetric dimethylarginine (ADMA), homocysteine, and nitric oxide (NO), and …
Treatment Of Ankylosing Spondylitis, İsmai̇l Sari, Mehmet Aki̇f Öztürk, Nurullah Akkoç
Treatment Of Ankylosing Spondylitis, İsmai̇l Sari, Mehmet Aki̇f Öztürk, Nurullah Akkoç
Turkish Journal of Medical Sciences
No abstract provided.
The Impact Of One Fraction Of 8 Gy Radiotherapy In Palliative Treatmentof Multiple Myeloma Patients With Painful Bone Destructions, Milda Rudzianskiene, Arturas Inciura, Elona Juozaityte, Rolandas Gerbutavicius, Renata Simoliuniene, Viktoras Rudzianskas, Greta Emilia Kiavialaitis
The Impact Of One Fraction Of 8 Gy Radiotherapy In Palliative Treatmentof Multiple Myeloma Patients With Painful Bone Destructions, Milda Rudzianskiene, Arturas Inciura, Elona Juozaityte, Rolandas Gerbutavicius, Renata Simoliuniene, Viktoras Rudzianskas, Greta Emilia Kiavialaitis
Turkish Journal of Medical Sciences
Background/aim: Radiotherapy is required to overcome pain and to promote recalcification in multiple myeloma (MM) patients. The aim of our prospective study was to evaluate the impact of one fraction of 8 Gy regimen in palliative treatment of MM. Materials and methods: Forty-six patients with MM and painful bone destructions were treated by 8 Gy single fraction regimen. The visual analog scale was used for evaluation of pain. Analgesic use was measured prior to and after radiotherapy (4, 12, and 24 weeks). Recalcification was evaluated with radiographs before and after radiotherapy at 1 and 3 months. Quality of life questionnaires …
Hypolipidemic Effects Of Nimesulide And Celecoxib In Experimentally Induced Hypercholesterolemia In Rabbits, Sagheer Ahmed, Saima Gul, Muhammad Zia-Ul-Haq, Muhammad Riaz
Hypolipidemic Effects Of Nimesulide And Celecoxib In Experimentally Induced Hypercholesterolemia In Rabbits, Sagheer Ahmed, Saima Gul, Muhammad Zia-Ul-Haq, Muhammad Riaz
Turkish Journal of Medical Sciences
Hypercholesterolemia plays an important role in the development of atherosclerotic disease, which is one of the leading causes of mortality in the world. Previous studies showed that cyclooxygenase (COX) inhibitors could be used in treating hypercholesterolemia. The present study was designed to test whether COX-2 inhibition can improve lipid profiles in hypercholesterolemia. Materials and methods: Rabbits were fed a high-cholesterol diet to produce hypercholesterolemia. The role of COX-2 was evaluated using celecoxib and nimesulide. Rabbits were divided into 4 groups: the first with normal healthy rabbits, second with high-cholesterol diet and pretreatment with saline, third with high-cholesterol diet and pretreatment …
Selenium Status In Blood, Urine, And Hair Samples Of Newly Diagnosed Pediatric Cancer Patients, Serap Karaman, Banu Mansuroğlu, Kadri̇ye Kizilbey, Serap Derman, Afi̇fe Bi̇nnaz Hazar
Selenium Status In Blood, Urine, And Hair Samples Of Newly Diagnosed Pediatric Cancer Patients, Serap Karaman, Banu Mansuroğlu, Kadri̇ye Kizilbey, Serap Derman, Afi̇fe Bi̇nnaz Hazar
Turkish Journal of Medical Sciences
Background/aim: Selenium (Se) is a trace element that has multiple functions. Low Se amounts in serum and hair have been reported in pediatric and adult cancer patients. The aim of our study was to evaluate Se levels in the serum, urine, and hair of pediatric cancer patients with leukemia, lymphoma, and solid tumors when compared with healthy children. Materials and methods: The concentrations of Se in the serum, hair, and urine of 32 Turkish children as healthy controls and 88 Turkish children diagnosed with acute leukemia (58), lymphoma (16), and solid tumors (14) were measured using inductively coupled plasma mass …
The Effects Of Prenatal Long-Duration Exposure To 900-Mhz Electromagnetic Field On The 21-Day-Old Newborn Male Rat Liver, Zehra Topal, Hati̇ce Hanci, Tolga Mercantepe, Hüseyi̇n Serkan Erol, Osman Nuri̇ Keleş, Haydar Kaya, Sevdegül Mungan, Ersan Odaci
The Effects Of Prenatal Long-Duration Exposure To 900-Mhz Electromagnetic Field On The 21-Day-Old Newborn Male Rat Liver, Zehra Topal, Hati̇ce Hanci, Tolga Mercantepe, Hüseyi̇n Serkan Erol, Osman Nuri̇ Keleş, Haydar Kaya, Sevdegül Mungan, Ersan Odaci
Turkish Journal of Medical Sciences
Background/aim: To determine what effect a 900-MHz electromagnetic field (EMF) applied in the prenatal period would have on the liver in the postnatal period. Materials and methods: At the start of the study, adult pregnant rats were divided into two groups, control and experimental. The experimental group was exposed to a 900-MHz EMF for 1 h daily during days 13?21 of pregnancy. After birth, no procedure was performed on either mothers or pups. Male rat pups (n = 6) from the control group mothers (CGMR) and male rat pups (n = 6) from the experimental group mothers (EGMR) were sacrificed …
Utility Of M30, An Apoptotic Serum Marker, In Liver Diseases, Aki̇f Altinbaş, Şahi̇n Çoban, Ömer Başar, Osman Yüksel
Utility Of M30, An Apoptotic Serum Marker, In Liver Diseases, Aki̇f Altinbaş, Şahi̇n Çoban, Ömer Başar, Osman Yüksel
Turkish Journal of Medical Sciences
The aim of this paper is to evaluate the role of apoptosis in some common liver diseases, and the utility of M30, an apoptotic serum marker, in the diagnosis of the severity of underlying hepatic injury. As is widely known, apoptosis is programmed cell death, and its deregulation results in an uncontrolled inflammatory process leading to upregulation of liver fibrogenesis. Both extrinsic and intrinsic pathways are crucial in apoptosis, and caspase cleavage of cytokeratin proteins occurs in both. Therefore, the measurement of caspase-cleaved cytokeratin fragments could be a novel method to assess the intensity of apoptotic cell numbers in epithelial …
Mucocutaneous Manifestations And The Relationship To Cd4 Lymphocyte Counts Among Turkish Hiv/Aids Patients In İstanbul, Turkey, Özlem Altuntaş Aydin, Hayat Kumbasar Karaosmanoğlu, Ramazan Korkusuz, Mehmet Özeren, Özcan Nazlican
Mucocutaneous Manifestations And The Relationship To Cd4 Lymphocyte Counts Among Turkish Hiv/Aids Patients In İstanbul, Turkey, Özlem Altuntaş Aydin, Hayat Kumbasar Karaosmanoğlu, Ramazan Korkusuz, Mehmet Özeren, Özcan Nazlican
Turkish Journal of Medical Sciences
Dermatologic findings differ among countries but no sufficient data about Turkish HIV-infected patients exist in the literature. Therefore, our aim in this study was to document the dermatologic manifestations and their relationships with CD4 cell counts among HIV/AIDS patients visiting our clinic for the first time in İstanbul, Turkey. Materials and methods: A retrospective analysis of 306 HIV/AIDS patients (260 men, mean age: 38.3 years) was done in a tertiary hospital in İstanbul from January 2006 to September 2012. Information on age, sex, transmission routes, socioeconomic and educational status, CD4 counts, and dermatologic findings was collected retrospectively from medical records. …
Salivary Glucose And Antioxidant Defense Markers In Type Ii Diabetes Mellitus, Sayeeda Mussavira, Mala Dharmalingam, Bindhu Omana Sukumaran
Salivary Glucose And Antioxidant Defense Markers In Type Ii Diabetes Mellitus, Sayeeda Mussavira, Mala Dharmalingam, Bindhu Omana Sukumaran
Turkish Journal of Medical Sciences
To evaluate salivary antioxidant defense markers, their correlation with salivary glucose, and glycemic status in type II diabetes mellitus (DM). Materials and methods: The study included 53 diabetic patients and 40 healthy subjects. Salivary glucose, blood glucose, and uric acid (UA) were determined by specific enzymatic methods. Total antioxidant activity (AOA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and total protein were determined spectrophotometrically. Results: Salivary UA (3.12 vs. 1.89 mg/dL), GSH (47 vs. 11.92 µg/mL), and total protein (375.12 vs. 202.23 mg/dL) were significantly higher (P < 0.001; r = 0.455, 0.735, 0.498 respectively) and AOA (653.1 vs. 897.3 µmol/L) was significantly lower in the DM group (P < 0.001, r = -0.431) compared to healthy controls. Among the antioxidant enzymes, CAT was significantly lower (1214 vs. 9468.9 kat) in the DM group (P < 0.001, r = -0.886). Spearman correlation analyses within the diabetic group showed a strong positive association between salivary glucose and blood glucose (P < 0.001, r = 0.9), salivary glucose and GSH, and salivary glucose and UA. Salivary glucose showed a negative correlation with AOA and CAT (P = 0.008, r = -0.447) in the diabetic group. Conclusion: Findings of this study, showing a strong correlation between salivary glucose and blood glucose as well as changes in antioxidant components in the DM group, suggest that saliva can be used for the diagnosis and management of DM.
Analysis Of Vaca/Caga Genotypes/Status In Helicobacter Pylori Isolates From Iranian Children And Their Association With Clinical Outcome, Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
Analysis Of Vaca/Caga Genotypes/Status In Helicobacter Pylori Isolates From Iranian Children And Their Association With Clinical Outcome, Tahereh Falsafi, Afsaneh Khani, Fatemeh Mahjoub, Ezat Asgarani, Nazli Sotoudeh
Turkish Journal of Medical Sciences
More than 50% of Iranian children are infected with Helicobacter pylori; however, no data exist about the association of vacA/cagA genotype/status with disease outcomes in them. We analyzed association of vacA/cagA genotypes/status of children's isolates with gastric inflammation status as the first step in H. pylori pathogenesis. Materials and methods: Antral biopsies for culture and histopathology were taken from 328 children in 1997-2009. vacA (s, m) alleles and cagA statuses of the isolates were determined by PCR. Histopathology was performed according to the Sydney system; gastritis was scored as normal, mild, moderate, severe, and follicular. Results: A total of 159 …
A Cgh Array Study In Nonsyndromic (Primary) Autism Patients: Deletions On16p13.11, 16p11.2, 1q21.1, 2q21.1q21.2, And 8p23.1, Kudret Esen Gümüşlü, Hakan Savli, Deni̇z Sünnetçi̇, Naci̇ Çi̇ne, Bülent Kara, Seda Eren Keski̇n, Rami̇s Ufuk Akkoyunlu
A Cgh Array Study In Nonsyndromic (Primary) Autism Patients: Deletions On16p13.11, 16p11.2, 1q21.1, 2q21.1q21.2, And 8p23.1, Kudret Esen Gümüşlü, Hakan Savli, Deni̇z Sünnetçi̇, Naci̇ Çi̇ne, Bülent Kara, Seda Eren Keski̇n, Rami̇s Ufuk Akkoyunlu
Turkish Journal of Medical Sciences
Background/aim: To detect specific molecular changes of DNA level in primary autism patients by using whole genome CGH array technology. Materials and methods: A cohort of 35 primary autism patients received clinical genetic testing by using an oligonucleotide-based CGH array platform to test for submicroscopic genomic deletions and duplications. Fluorescent in situ hybridization was performed in seven patients for confirmation of the results. Results: We found 16p13.11 deletion in thirteen patients, 16p11.2 deletion in twelve patients, 1q21.1 deletion in ten patients, 2q21.1q21.2 deletion in eight patients, and 8p23.1 deletion in seven patients. Conclusion: Our study indicates that genes in 16p13.11, …
Comparison Of The Analgesic Effects Of Paracetamol And Tramadol In Lumbar Disc Surgery, Mehmet Zi̇ya Yilmaz, Bahri̇ye Bi̇nnur Sarihasan, Ebru Kelsaka, Ni̇lay Taş, Aysun Çağlar Torun, Ersi̇n Köksal, Eni̇s Kuruoğlu
Comparison Of The Analgesic Effects Of Paracetamol And Tramadol In Lumbar Disc Surgery, Mehmet Zi̇ya Yilmaz, Bahri̇ye Bi̇nnur Sarihasan, Ebru Kelsaka, Ni̇lay Taş, Aysun Çağlar Torun, Ersi̇n Köksal, Eni̇s Kuruoğlu
Turkish Journal of Medical Sciences
Background/aim: To compare the postoperative analgesic efficacy and side effects of paracetamol and tramadol in patients undergoing lumbar disc surgery. Materials and methods: Group P (paracetamol group) was given 1 g of paracetamol intravenously 30 min before the end of the operation and 1 g each day at 6-h intervals. Group T (tramadol group) was given 1.5 mg/kg of tramadol as a loading dose and patient-controlled analgesia for 1 day. Hemodynamic parameters, modified Aldrete score, Ramsay sedation scale score, patient satisfaction scale (PSS) score, visual analog scale (VAS) score, nausea/vomiting scale score, and additional analgesic needs/times were recorded. Results: PSS …
Relationship Among Mif, Mcp-1, Viral Loads, And Hbs Ag Levelsin Chronic Hepatitis B Patients, Hayati̇ Güneş, Rafet Mete, Murat Aydin, Bi̇rol Topçu, Mustafa Oran, Mustafa Doğan, Oğuzhan Yildirim, İlknur Erdem, Aynur Eren Topkaya, Ahmet Gürel
Relationship Among Mif, Mcp-1, Viral Loads, And Hbs Ag Levelsin Chronic Hepatitis B Patients, Hayati̇ Güneş, Rafet Mete, Murat Aydin, Bi̇rol Topçu, Mustafa Oran, Mustafa Doğan, Oğuzhan Yildirim, İlknur Erdem, Aynur Eren Topkaya, Ahmet Gürel
Turkish Journal of Medical Sciences
Background/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters. Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant. Results: The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated. Conclusion: We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.
Vitamin And Mineral Deficiency In Children Newly Diagnosed With Celiac Disease, Erdem Topal, Ferat Çatal, Nurdan Yildirim Acar, Hali̇me Ermi̇şteki̇n, Muhammed Selçuk Si̇nanoğlu, Hamza Karabi̇ber, Mukadder Ayşe Seli̇moğlu
Vitamin And Mineral Deficiency In Children Newly Diagnosed With Celiac Disease, Erdem Topal, Ferat Çatal, Nurdan Yildirim Acar, Hali̇me Ermi̇şteki̇n, Muhammed Selçuk Si̇nanoğlu, Hamza Karabi̇ber, Mukadder Ayşe Seli̇moğlu
Turkish Journal of Medical Sciences
Background/aim: To establish the frequency of vitamin and mineral deficiency in children newly diagnosed with celiac disease. Materials and methods: The files of patients diagnosed with celiac disease in our Pediatric Gastroenterology Clinic from June 2008 to June 2013 were reviewed retrospectively. Results: A total of 52 pediatric patients diagnosed with celiac disease via serology and duodenal biopsy and who fulfilled the study criteria were enrolled in the study. The mean diagnosis age of the patients was 8.5 ± 3.9 years and 33 (63.5%) of the patients were female. Vitamin D, vitamin A, vitamin E, zinc, and iron deficiencies were …
Prevalence Of Helicobacter Pylori Caga, Baba2, And Dupa Genotypes Andcorrelation With Clinical Outcome In Malaysian Patients With Dyspepsia, Hussein Ali Osman, Habsah Hasan, Rapeah Suppian, Syed Hassan, Dzulkarnaen Zakaria Andee, Noorizan Abdul Majid, Bin Alwi Zilfalil
Prevalence Of Helicobacter Pylori Caga, Baba2, And Dupa Genotypes Andcorrelation With Clinical Outcome In Malaysian Patients With Dyspepsia, Hussein Ali Osman, Habsah Hasan, Rapeah Suppian, Syed Hassan, Dzulkarnaen Zakaria Andee, Noorizan Abdul Majid, Bin Alwi Zilfalil
Turkish Journal of Medical Sciences
Background/aim: The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes. Materials and methods: H. pylori genotypes cagA, babA2, and dupA were identified by polymerase chain reactions from gastric biopsy samples in 105 H. pylori-positive patients. Results: The positive rates for cagA, babA2, and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, and 22.9%, respectively. cagA was more prevalent …
Asymmetric Dimethylarginine Is Not A Good Predictor Of Ischemiausing Myocardial Perfusion Scintigraphy, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ni̇lgün Yildiz, Ayşe Yilmaz, Yusuf Aslantaş, Serkan Bulur, Huri̇ Ti̇lla İlçe, Mustafa Yildirim, Ramazan Memi̇şoğullari, Ahmet Semi̇h Doğan
Asymmetric Dimethylarginine Is Not A Good Predictor Of Ischemiausing Myocardial Perfusion Scintigraphy, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ni̇lgün Yildiz, Ayşe Yilmaz, Yusuf Aslantaş, Serkan Bulur, Huri̇ Ti̇lla İlçe, Mustafa Yildirim, Ramazan Memi̇şoğullari, Ahmet Semi̇h Doğan
Turkish Journal of Medical Sciences
Background/aim: Asymmetric dimethylarginine (ADMA) plays role in the pathogenesis of coronary artery disease and related mortality and morbidity through a number of mechanisms. We hypothesized that plasma ADMA levels would be increased in the presence of reversible ischemia as measured by GATED single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy (MPS). Materials and methods: Fasting i.v. blood samples were drawn before testing. All patients underwent 99mTc-sestamibi GATED SPECT MPS with a one-day stress-rest protocol; the images were visually analyzed. Post-stress GATED parameters, including ejection fraction, end systolic and end diastolic volumes, and automatic stress defect scores, were recorded. Results: …