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Articles 2371 - 2400 of 4871
Full-Text Articles in Medicine and Health Sciences
Investigating The In Vitro Synergistic Activities Of Several Antibiotic Combinationsagainst Carbapenem-Resistant Acinetobacter Baumannii Isolates, Sevi̇m Yavaş, Meltem Arzu Yetki̇n, Bi̇rcan Kayaaslan, Ali̇ye Baştuğ, Hali̇de Aslaner, Ayşe But, Di̇lek Kanyilmaz, Berri̇n Sari, Esragül Akinci, Hurrem Bodur
Investigating The In Vitro Synergistic Activities Of Several Antibiotic Combinationsagainst Carbapenem-Resistant Acinetobacter Baumannii Isolates, Sevi̇m Yavaş, Meltem Arzu Yetki̇n, Bi̇rcan Kayaaslan, Ali̇ye Baştuğ, Hali̇de Aslaner, Ayşe But, Di̇lek Kanyilmaz, Berri̇n Sari, Esragül Akinci, Hurrem Bodur
Turkish Journal of Medical Sciences
Background/aim: Acinetobacter baumannii (A. baumannii) is one of the most common healthcare-associated infectious agents worldwide. The aim of this study was to investigate the in vitro synergistic activities of several antibiotic combinations against carbapenem-resistant (CR) A. baumannii isolates. Materials and methods: Eighteen CR A. baumannii strains were isolated from the patients who were hospitalized in the intensive care unit between June 2012 and August 2012. The in vitro effects of single and binary combinations of meropenem (MEM), colistin (CST), tigecycline (TGC), and sulbactam (SUL) on these isolates were determined using the Epsilometer test (E-test) method. Results: All 18 isolates were …
Molecular Prevalence And Antibiotics Resistance Pattern Of Class A Bla Ctx-M-1 And Bla Tem-1 Beta Lactamases In Uropathogenic Escherichia Coli Isolates From Pakistan, Hazir Rahman, Madiha Naeem, Ilyas Khan, Jafar Khan, Mohammad Haroon, Fazli Bari, Rahim Ullah, Muhammad Qasim
Molecular Prevalence And Antibiotics Resistance Pattern Of Class A Bla Ctx-M-1 And Bla Tem-1 Beta Lactamases In Uropathogenic Escherichia Coli Isolates From Pakistan, Hazir Rahman, Madiha Naeem, Ilyas Khan, Jafar Khan, Mohammad Haroon, Fazli Bari, Rahim Ullah, Muhammad Qasim
Turkish Journal of Medical Sciences
Background/aim: Extended spectrum beta lactamase (ESBL) production among E. coli is one of the principal mechanisms that augment resistance to antibiotics. In the current study the molecular detection of class A beta lactamases among uropathogenic Escherichia coli was evaluated. Materials and methods: A total of 355 urine samples were collected from a tertiary care hospital in Peshawar. The ESBL production among E. coli isolates was detected by using the disc synergy diffusion method. Moreover, the molecular detection of bla TEM-1 and bla CTX-M-1 ESBLs, the antibiotic resistance pattern, and the minimum inhibitory concentrations (MICs) were also documented. Results: Among the …
An Investigation Of The Bactericidal Activity Of Chlorhexidine Digluconateagainst Multidrug-Resistant Hospital Isolates, Meli̇ke Eki̇zoğlu, Meral Sağiroğlu, Ekrem Kiliç, Ayşe Gülşen Hasçeli̇k
An Investigation Of The Bactericidal Activity Of Chlorhexidine Digluconateagainst Multidrug-Resistant Hospital Isolates, Meli̇ke Eki̇zoğlu, Meral Sağiroğlu, Ekrem Kiliç, Ayşe Gülşen Hasçeli̇k
Turkish Journal of Medical Sciences
Background/aim: Hospital infections are among the most prominent medical problems around the world. Using proper biocides1397645907in an appropriate way is critically important in overcoming this problem. Several reports have suggested that microorganisms may develop resistance or reduce their susceptibility to biocides, similar to the case with antibiotics. In this study we aimed to determine the antimicrobial activity of chlorhexidine digluconate against clinical isolates. Materials and methods: The susceptibility of 120 hospital isolated strains of 7 bacterial genera against chlorhexidine digluconate was determined by agar dilution test, using minimum inhibitory concentration (MIC) values and the EN 1040 Basic Bactericidal Activity Test …
Hepatoprotective And Antidiabetic Activities Of Fraxinus Angustifolia Vahl Extracts In Animal Models: Characterization By High Performance Liquid Chromatography Analysis, Zineb Medjahed, Dina Atman-Kilani, Marie-Laure Fauconnier, Gaetan Richard, Djebbar Atmani
Hepatoprotective And Antidiabetic Activities Of Fraxinus Angustifolia Vahl Extracts In Animal Models: Characterization By High Performance Liquid Chromatography Analysis, Zineb Medjahed, Dina Atman-Kilani, Marie-Laure Fauconnier, Gaetan Richard, Djebbar Atmani
Turkish Journal of Medical Sciences
Background/aim: The present study was designed to explore antidiabetic and hepatoprotective potentials of Fraxinus angustifolia leaf (FAL) and bark (FAB) extracts in vivo. Materials and methods: Streptozotocin (STZ)-induced diabetic rats, pretreated with the extracts (25 and 50 mg/kg), were monitored for fasting blood glucose (FBG) levels. Hepatoprotective potential was examined after injection of an excessive dose of paracetamol (10 g/60 kg) by analysis of biochemical parameters (transaminases, bilirubin), malondialdehyde (MDA) levels, and histological sections. high performance liquid chromatography analysis was also performed for partial characterization. Results: A considerable hypoglycemic effect was noticed 2 h after the STZ-induction, with a higher …
Intestinal Trefoil Factor Increased The Bcl-2 Level In A Necrotizingenterocolitis Neonate Rat Model, Xiaolian Yi, Xiaojun Chang, Jijie Wang, Caixia Yan, Binghong Zhang
Intestinal Trefoil Factor Increased The Bcl-2 Level In A Necrotizingenterocolitis Neonate Rat Model, Xiaolian Yi, Xiaojun Chang, Jijie Wang, Caixia Yan, Binghong Zhang
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the therapeutic effect of intestinal trefoil factor (ITF) on necrotizing enterocolitis (NEC) by observing the pathological changes and detecting the protein level differences in Caspase-3, Bax, and Bcl-2 in an NEC neonate rat model. Materials and methods: A Wistar rat model of NEC was established and 30 one-day-old neonate Wistar rats were randomly divided into three groups including a normal control (group A), NEC rats treated with 0.2 ml physiological saline through intraperitoneal (i.p.) injection (group B), and NEC rats treated with 0.2 mg ITF by i.p injection (group C). Results: …
Paternal Exposure To Low-Dose Lead Acetate: Effect On Implantation Rate,Pregnancy Outcome, And Sex Ratio In Mice, Basima Al-Juboori, Farqad Hamdan, Anam Al-Salihi
Paternal Exposure To Low-Dose Lead Acetate: Effect On Implantation Rate,Pregnancy Outcome, And Sex Ratio In Mice, Basima Al-Juboori, Farqad Hamdan, Anam Al-Salihi
Turkish Journal of Medical Sciences
Background/aim: It has been reported from in vivo exposed experimental animals that paternal lead exposure reduces birth rate; however, there is limited evidence to suggest a decrease in the proportion of male births. This study investigated the role of paternal exposure to lower lead acetate doses on early embryonic development (implantation) and the sex ratio of their offspring. Materials and methods: In total 180 Swiss Webster mice were used (60 male and 120 female). The males were divided into 3 groups: G1 (untreated group), G2 (treated daily with 50 μg/kg BW lead acetate), and G3 (treated daily with 100 μg/kg …
First Report On The Distribution Of 3435c>T Abcb1/Mdr1polymorphism In Healthy Bosniak Population, Grazyna Adler, Anna Pawinska-Matecka, Agnieszka Garstka, Nermin Nusret Salkic, Amina Valjevac, Beata Karakiewicz
First Report On The Distribution Of 3435c>T Abcb1/Mdr1polymorphism In Healthy Bosniak Population, Grazyna Adler, Anna Pawinska-Matecka, Agnieszka Garstka, Nermin Nusret Salkic, Amina Valjevac, Beata Karakiewicz
Turkish Journal of Medical Sciences
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Depression, Anxiety, And Their Relation With Clinical Parametersand Androgen Levels In Hirsute Women, Leyla Irak, Hali̇se Çinar Yavuz, Berçem Ayçi̇çek Doğan, Türkan Mete, Di̇lek Berker, Serdar Güler
Depression, Anxiety, And Their Relation With Clinical Parametersand Androgen Levels In Hirsute Women, Leyla Irak, Hali̇se Çinar Yavuz, Berçem Ayçi̇çek Doğan, Türkan Mete, Di̇lek Berker, Serdar Güler
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to assess the prevalence of anxiety and depression among patients with hirsutism and to evaluate the relationships of anxiety and depression with clinical parameters and androgen levels. Materials and methods: One hundred and seven women with hirsutism were enrolled in the study. All participants completed standardized questionnaires to assess depression (Beck Depression Inventory (BDI)) and anxiety (Beck Anxiety Inventory (BAI)). The Ferriman-Gallwey (FG) scores, body mass indexes (BMIs), homeostatic model assessments of insulin resistance (HOMA-IR), and serum androgen levels of all patients were obtained. Results: Seventy-four of the 107 patients (69.15%) had BDI …
The Relationship Of Mean Platelet Volume With Microalbuminuriain Type 2 Diabetic Patients, Seyi̇t Murat Bayram, Gül Gürsoy, Asli Araz Güngör, Fati̇h Güngör, Eray Atalay
The Relationship Of Mean Platelet Volume With Microalbuminuriain Type 2 Diabetic Patients, Seyi̇t Murat Bayram, Gül Gürsoy, Asli Araz Güngör, Fati̇h Güngör, Eray Atalay
Turkish Journal of Medical Sciences
Background/aim: Activation and size of platelets have been suggested to be involved in the pathogenesis of vascular complications in diabetes mellitus. The purpose of the present study was to investigate the association of mean platelet volume with microalbuminuria in type 2 diabetic patients. Materials and methods: Mean platelet volume levels were investigated in healthy participants and type 2 diabetic patients with and without microalbuminuria. After their mean platelet volume values were compared, correlation of mean platelet volume with sex, duration of diabetes, microalbuminuria, fasting blood glucose, hemoglobin A1c, creatinine clearance, and body mass index was examined. Results: Mean platelet volume …
Total White Blood Cell Count, Liver Enzymes, And Metabolic Syndrome In Schizophrenia, Görkem Karakaş Uğurlu, Semra Ulusoy Kaymak, Mustafa Uğurlu, Si̇bel Örsel, Ali̇ Çayköylü
Total White Blood Cell Count, Liver Enzymes, And Metabolic Syndrome In Schizophrenia, Görkem Karakaş Uğurlu, Semra Ulusoy Kaymak, Mustafa Uğurlu, Si̇bel Örsel, Ali̇ Çayköylü
Turkish Journal of Medical Sciences
Background/aim: Metabolic syndrome (MetS) is an important clinical issue in patients with schizophrenia, but its associated factors are still ambiguous. The aim of the present study was to test whether there are any associations between MetS and white blood cell (WBC) levels, liver enzymes, or sociodemographic variables. Materials and methods: The study included 91 patients with a diagnosis of schizophrenia. We used the National Cholesterol Education Program's Third Adult Treatment Protocol criteria to evaluate MetS in patients. Schizophrenia patients with MetS were compared with those without MetS on the basis of demographic and clinical characteristics and total WBC counts. We …
Evaluation Of Borrelia Burgdorferi Sensu Lato Seroprevalencein The Province Of Bolu, Turkey, Özlem Bucak, Mücahi̇de Esra Koçoğlu, Teki̇n Taş, Firat Zafer Mengeloğlu
Evaluation Of Borrelia Burgdorferi Sensu Lato Seroprevalencein The Province Of Bolu, Turkey, Özlem Bucak, Mücahi̇de Esra Koçoğlu, Teki̇n Taş, Firat Zafer Mengeloğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of the present study was to determine the seroprevalence of Borrelia burgdorferi sensu lato in the city center and the province of Bolu, Turkey. Materials and methods: A stratified sampling method was used to determine the study population. A total of 196 blood samples were collected. A questionnaire was completed by each participant in the study. ELISA was performed and positive serologic results were confirmed using western blotting. Data were analyzed statistically using the chi-square test. Results: Seropositivity rates of B. burgdorferi IgM and IgG were determined as 14.8% (29/196) and 13.7% (27/196) respectively by ELISA. A …
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
The Effects Of Bupivacaine Combined With Different Adjuvants On Block Onset And Duration And On Ion Channel Expressions (Scn9a, Trpm) In Sciatic Nerve Block In Rats, Nurgül Dolu, Levent Şahi̇n, Davut Si̇nan Kaplan, Tuncer Demi̇r, Hasan Şi̇mşek, Mehri̇can Şahi̇n, Beyhan Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. Materials and methods: Rats were divided into five groups: Group S (sham), saline solution; Group B, bupivacaine; Group BD, bupivacaine + dexmedetomidine; Group BC, bupivacaine + clonidine; and Group BE, bupivacaine + epinephrine. For each group, 0.2 mL of local anesthetic was injected into the sciatic nerve bifurcation …
Growth Of Biometric Components And Development Of Refractive Errors In Premature Infants With Or Without Retinopathy Of Prematurity, Özdemi̇r Özdemi̇r, Zühal Özen Tunay, Damla Ergi̇ntürk Acar
Growth Of Biometric Components And Development Of Refractive Errors In Premature Infants With Or Without Retinopathy Of Prematurity, Özdemi̇r Özdemi̇r, Zühal Özen Tunay, Damla Ergi̇ntürk Acar
Turkish Journal of Medical Sciences
Background/aim: To investigate the biometric components and refractive errors in premature infants with or without retinopathy of prematurity (ROP). Materials and methods: Anterior chamber depth, lens thickness, vitreous length, and axial length were measured with an ultrasound biometer. Cycloplegic refraction was performed by streak skiascopy. Infants with or without ROP were grouped according to postmenstrual age at the time of ocular examination: Group 1, ≤33 weeks; Group 2, 34-37 weeks; Group 3, 38-41 weeks; Group 4, 42-45 weeks; Group 5, ?46 weeks. Results: The mean postnatal age of 894 infants (451 females and 443 males) was 8.7 ± 4.5 weeks, …
Polymorphisms In Androgen Metabolism Genes Ar, Cyp1b1, Cyp19, And Srd5a2 And Prostate Cancer Risk And Aggressiveness In Bulgarian Patients, Darina Kachakova, Atanaska Mitkova, Elenko Popov, Olga Beltcheva, Alexandrina Vlahova, Tihomir Dikov, Svetlana Christova, Vanio Mitev, Chavdar Slavov, Radka Kaneva
Polymorphisms In Androgen Metabolism Genes Ar, Cyp1b1, Cyp19, And Srd5a2 And Prostate Cancer Risk And Aggressiveness In Bulgarian Patients, Darina Kachakova, Atanaska Mitkova, Elenko Popov, Olga Beltcheva, Alexandrina Vlahova, Tihomir Dikov, Svetlana Christova, Vanio Mitev, Chavdar Slavov, Radka Kaneva
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to elucidate the role of polymorphisms in AR, CYP1B1, CYP19, and SRD5A2 genes for prostate cancer (PC) development in Bulgarian patients. Materials and methods: We genotyped 246 PC patients and 261 controls (155 with benign prostate hyperplasia and 107 healthy population controls) using direct sequencing, PCR-RFLP, SSCP, and fragment analysis. Results: The allele and genotype frequencies of most of the studied variants did not differ significantly between cases and controls. Increased frequencies of the C/C genotype and C allele of rs1056837 in CYP1B1, and genotype 7/8 of the (TTTA)n repeat polymorphism in CYP19, …
Genetic Association Of The Col1a1 Gene Promoter ?1997 G/T (Rs1107946) Andsp1 +1245 G/T (Rs1800012) Polymorphisms And Keloid Scars In A Jeddah Population, Sabah A. Linjawi, Sanaa E. Tork, Risa M. Shabiah
Genetic Association Of The Col1a1 Gene Promoter ?1997 G/T (Rs1107946) Andsp1 +1245 G/T (Rs1800012) Polymorphisms And Keloid Scars In A Jeddah Population, Sabah A. Linjawi, Sanaa E. Tork, Risa M. Shabiah
Turkish Journal of Medical Sciences
Background/aim: Scars develop at the end of the natural wound-healing process and are characterized by excessive collagen deposition, particularly types I and III collagen. This study aimed to investigate the genetic association of COL1A1 ?1997 G/T (rs1107946) and COL1A1 Sp1 +1245 G/T (rs1800012) polymorphisms with the incidence of scars. Materials and methods: A case-control association study was conducted with 84 volunteers from Jeddah, Saudi Arabia (47 patients and 37 controls). The allele frequency distribution and nucleotide genotypes of ?1997 G/T, +1245 G/T were ascertained by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: Our results indicated …
Clinical Outcomes And Optical Performance Of Four Differentmultifocal Intraocular Lenses, Başak Bostanci Ceran, Tamer Takmaz, İzzet Can, Güli̇zar Demi̇rok, Betül Seher Uysal
Clinical Outcomes And Optical Performance Of Four Differentmultifocal Intraocular Lenses, Başak Bostanci Ceran, Tamer Takmaz, İzzet Can, Güli̇zar Demi̇rok, Betül Seher Uysal
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to evaluate clinical outcomes and optical performance of 4 different multifocal intraocular lenses (IOLs). Materials and methods: Ninety eyes of 51 patients who received Reviol MFM 611, Reviol MFM 625, Acri.LISA, and ReSTOR SN6AD3 multifocal IOLs after cataract surgery were retrospectively evaluated. The patients were similar in terms of age, sex, cataract hardness and axial length. The mean outcome measures were uncorrected and corrected distance visual acuity (UDVA, CDVA), distance-corrected intermediate and near visual acuity (DCIVA, DCNVA), intra or postoperative complications, and contrast sensitivity (CS) results under mesopic conditions. The mean follow …
Childhood Acute Lymphoblastic Leukemia: Refusal And Abandonmentof Treatment In The Southeast Of Iran, Majid Naderi, Samira Esmaeili Reykande, Shadi Tabibian, Shaban Alizadeh, Akbar Dorgalaleh, Morteza Shamsizadeh
Childhood Acute Lymphoblastic Leukemia: Refusal And Abandonmentof Treatment In The Southeast Of Iran, Majid Naderi, Samira Esmaeili Reykande, Shadi Tabibian, Shaban Alizadeh, Akbar Dorgalaleh, Morteza Shamsizadeh
Turkish Journal of Medical Sciences
Background/aim: Acute lymphoblastic leukemia (ALL) accounts for 25% of all malignancies in children. ALL treatment has standard protocols, and treatment abandonment is a main cause of treatment failure. Therefore, this study aimed to assess the relationship between socioeconomic status and rate as well as cause of abandoned treatment in children with ALL in the southeast of Iran. Materials and methods: This retrospective, descriptive cohort study was conducted with ALL patients at the Ali Asghar Hospital in the city of Zahedan. The study population included 22 children with different subtypes of ALL who had abandoned their treatment. A structural questionnaire was …
Impact Of Different Anesthetic Managements In Outcomes Of Transcatheteraortic Valve Implantation: The First Turkish Experience, Elvi̇n Kesi̇mci̇, Ezgi̇ Erkiliç, Tüli̇n Gümüş, Orhan Kanbak
Impact Of Different Anesthetic Managements In Outcomes Of Transcatheteraortic Valve Implantation: The First Turkish Experience, Elvi̇n Kesi̇mci̇, Ezgi̇ Erkiliç, Tüli̇n Gümüş, Orhan Kanbak
Turkish Journal of Medical Sciences
Background/aim: Transcatheter aortic valve implantation (TAVI) has emerged as a new therapy in aortic stenosis patients with high operative risk. Advances in experiences have shifted the choice of anesthesia from general to local anesthesia and sedation for these patients. We compared our anesthetic experiences in our institute in a period of 2.5 years. Materials and methods: A total of 151 (86 females, 65 males, mean age 76 years) symptomatic aortic stenosis patients undergoing transfemoral TAVI under general anesthesia (GA) (n = 79) and local anesthesia and sedation (LAS) (n = 72) were evaluated retrospectively in regards to anesthetic issues. Results: …
The Impact Of Calcineurin Inhibitors And Mammalian Target Of Rapamycininhibitors On Anxiety And Depression Scores In Kidney Transplant Patients, Ebru Gök Oğuz, Gülay Ulusal Okyay, Hadi̇m Akoğlu, Güner Karaveli̇ Gürsoy, Zafer Ercan, Özgür Merhametsi̇z, Başol Canbakan, Mehmet Deni̇z Ayli
The Impact Of Calcineurin Inhibitors And Mammalian Target Of Rapamycininhibitors On Anxiety And Depression Scores In Kidney Transplant Patients, Ebru Gök Oğuz, Gülay Ulusal Okyay, Hadi̇m Akoğlu, Güner Karaveli̇ Gürsoy, Zafer Ercan, Özgür Merhametsi̇z, Başol Canbakan, Mehmet Deni̇z Ayli
Turkish Journal of Medical Sciences
Background/aim: Depression and anxiety are prevalent symptoms in kidney transplant patients. We aimed to evaluate the frequency and the severity of depression and anxiety symptoms in kidney transplant recipients using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). The data were compared between the patients on CNI-based and mTORi-based maintenance immunosuppressive regimens. Materials and methods: A total of 94 kidney transplant patients were enrolled in the study after exclusion of the patients already taking neuropsychiatric medications or unwilling to participate in the study. Participants were asked to self-report the inventories. Results: Analysis of data showed that 62 (66%) …
Colistin Efficacy In The Treatment Of Multidrug-Resistant And Extremelydrug-Resistant Gram-Negative Bacterial Infections*, Çi̇ğdem Banu Çeti̇n, Deni̇z Özer Türk, Şebnem Şenol, Gönül Di̇nç Horasan, Özlem Tünger
Colistin Efficacy In The Treatment Of Multidrug-Resistant And Extremelydrug-Resistant Gram-Negative Bacterial Infections*, Çi̇ğdem Banu Çeti̇n, Deni̇z Özer Türk, Şebnem Şenol, Gönül Di̇nç Horasan, Özlem Tünger
Turkish Journal of Medical Sciences
Background/aim: Colistin is used as a salvage therapy for multidrug-resistant and extremely drug-resistant gram-negative bacterial infections. Our aim was to evaluate colistin efficiency and toxicity in the treatment of these resistant gram-negative bacterial infections. Materials and methods: This is a retrospective study carried out in a tertiary care hospital during 2011-2013. Study data were collected from the medical records and consultations of the infectious diseases clinic. Results: The study group included 158 patients with nosocomial infections and 136 (86.1%) of them were hospitalized in the ICU. Respiratory tract infections were the most commonly observed ones (n = 103, 65.2%). The …
Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r
Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to determine the reference ranges of 25-hydroxyvitamin D3 (25(OH)vitD3) by an indirect method using data obtained from patients over the course of 3 years. Materials and methods: The 25(OH)vitD3 test results of the patients who applied to the medical biochemistry laboratory of Balıkesir State Hospital between the years of 2010 and 2014 were analyzed. Patient data were retrospectively taken from the laboratory information system. The 25(OH)vitD3 levels of patients were examined after exclusion of outliers. Patients were divided into subgroups according to season, sex, and age. The central 95% reference intervals were calculated …
Genotypes And Virulence Factors Of Candida Species Isolated From Oralcavities Of Patients With Type 2 Diabetes Mellitus, Soley Arslan, Ayşe Nedret Koç, Ahmet Ercan Şekerci̇, Fati̇h Tanriverdi̇, Hafi̇ze Sav, Gonca Aydemi̇r, Hali̇t Di̇ri̇
Genotypes And Virulence Factors Of Candida Species Isolated From Oralcavities Of Patients With Type 2 Diabetes Mellitus, Soley Arslan, Ayşe Nedret Koç, Ahmet Ercan Şekerci̇, Fati̇h Tanriverdi̇, Hafi̇ze Sav, Gonca Aydemi̇r, Hali̇t Di̇ri̇
Turkish Journal of Medical Sciences
Background/aim: This study compared the genotypes and virulence factors of Candida species isolated from oral cavities of healthy individuals and patients with diabetes mellitus (DM). Materials and methods: A total of 142 healthy individuals and 73 diabetic patients participated in this study. Study populations were classified into 4 groups as follows: Group I " Healthy, without caries; Group II " Healthy, with caries; Group III " DM, with caries; Group IV " DM, without caries. Diabetic patients' blood glucose and hemoglobin A1c concentrations were determined. Identification of Candida species was performed with conventional methods. Biofilm production, proteinase, phospholipase, and esterase …
Liporotein-Associated Phospholipase-A2 Can Be A Diagnostic Marker Inthe Early Stage Diagnosis Of Acute Mesenteric Ischemia, Tarik Acar, Sedat Koçak, Başar Cander, Mehmet Ergi̇n, Cesareddi̇n Di̇kmetaş
Liporotein-Associated Phospholipase-A2 Can Be A Diagnostic Marker Inthe Early Stage Diagnosis Of Acute Mesenteric Ischemia, Tarik Acar, Sedat Koçak, Başar Cander, Mehmet Ergi̇n, Cesareddi̇n Di̇kmetaş
Turkish Journal of Medical Sciences
Background/aim: The purpose of this experimental study was to investigate the role of lipoprotein-associated phospholipase-A2 (Lp-PLA2) in the diagnosis of acute mesenteric ischemia (AMI) in the early stage. Materials and methods: Twenty-seven New Zealand rabbits were randomly divided into 3 groups in this study. Blood specimens were obtained from the groups at hours 0, 1, 3, and 6. Using the blood samples drawn from all groups, Lp-PLA2 and C-reactive protein (CRP) parameters were investigated. Results: There was a significant rise in the levels of both Lp-PLA2 and CRP starting at hour 1 (P < 0.05) (hour 1; Lp-PLA2, P = 0.003) in the ischemia group. In the sham group, the levels of Lp-PLA2 and CRP started to rise at hour 3 (P < 0.05) (hour 3; Lp-PLA2, P = 0.011). At hour 6 of ischemia, the area under the ROC curve was 100%, and the cut-off value of 63.91 ng/mL revealed a sensitivity of 88% and a specificity of 100% for Lp-PLA2. Conclusion: These findings showed the role of serum Lp-PLA2 and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA2 in the early diagnosis of AMI.
Promoter Methylation Profile Of Gstp1 And Rassf1a In Prostate Cancerand Benign Hyperplasia In Vietnamese Men, Thi Thuong Lan Vo, Bich Thuan Ta, Van To Ta, Dieu Linh Vuong, Quynh Uyen Nguyen
Promoter Methylation Profile Of Gstp1 And Rassf1a In Prostate Cancerand Benign Hyperplasia In Vietnamese Men, Thi Thuong Lan Vo, Bich Thuan Ta, Van To Ta, Dieu Linh Vuong, Quynh Uyen Nguyen
Turkish Journal of Medical Sciences
Background/aim: The GSTP1 and RASSF1A methylations that were considered as prostate cancer-specific molecular biomarkers have been extensively reported in Western/American patients with prostate cancer but are rarely reported in Southeast Asian patients. In the present study, the methylation status of the GSTP1 and RASSF1A promoters was evaluated in prostate cancer (PCa) and benign prostate hyperplasia (BPH) tissues from Vietnamese men. Materials and methods: The accuracy of methylation-specific polymerase chain reaction (MSP) was validated to analyze the methylation pattern of GSTP1 and RASSF1A in 59 PCa and 37 BPH patients, respectively. The methylation status was confirmed by the sequencing of cloned …
Crp, Hba1c, Lipid, And Biochemical Parameters And Their Relation With Maternal Visceral Adipose Tissue And Subcutaneous Fat Tissue Thickness, Müzeyyen Duran, Aydin Köşüş, Nermi̇n Köşüş, Ni̇lgün Turhan
Crp, Hba1c, Lipid, And Biochemical Parameters And Their Relation With Maternal Visceral Adipose Tissue And Subcutaneous Fat Tissue Thickness, Müzeyyen Duran, Aydin Köşüş, Nermi̇n Köşüş, Ni̇lgün Turhan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to find whether maternal visceral tissue (VAT) or subcutaneous fat tissue (SCFT) thicknesses are associated with CRP, HbA1c, lipid, and biochemical parameters in the first trimester of pregnancy. Materials and methods: Ninety pregnant women were enrolled. Body mass index (BMI), VAT, and SCFT were measured. The best cut-off points for grouping subjects were found to be 4 cm for VAT and 2 cm for SCFT. Venous blood samples were collected. Results: VAT was higher than 4 cm in all cases with high BMIs. High CRP and HbA1c were found in 45.5% and 18.2% …
Analysis Of The Hip Fracture Records Of A Central Training And Research Hospital By Selected Characteristics, Deni̇z Çankaya, Burak Yoldaş, Eli̇f Çankaya, Yalçin Çakir, Cemal Aydin, Abdullah Yalçin Tabak
Analysis Of The Hip Fracture Records Of A Central Training And Research Hospital By Selected Characteristics, Deni̇z Çankaya, Burak Yoldaş, Eli̇f Çankaya, Yalçin Çakir, Cemal Aydin, Abdullah Yalçin Tabak
Turkish Journal of Medical Sciences
Background/aim: Despite the importance of hip fractures, very few studies have assessed their epidemiological characteristics in Turkey. The aim of this study was to evaluate the frequency and demography of hip fractures from the recent data of a central training and research hospital. Materials and methods: In this descriptive study, we identified hip fracture cases between 2009 and 2013. The age, sex, region, injury pattern, and calendar year for all patients were evaluated. Results: Among the 687 patients (488 women, 199 men) described in our clinic's records, 122, 131, 144, 138, and 154 patients applied with hip fractures from the …
Clinical Features Of Infants Treated For Severe Retinopathy Of Prematurity: 8-Yearstudy From A Large Tertiary Neonatal Intensive Care Unit In Turkey, Zühal Özen Tunay, Özdemi̇r Özdemi̇r, Damla Ergi̇ntürk Acar, İkbal Seza Petri̇çli̇, Şeri̇fe Suna Oğuz
Clinical Features Of Infants Treated For Severe Retinopathy Of Prematurity: 8-Yearstudy From A Large Tertiary Neonatal Intensive Care Unit In Turkey, Zühal Özen Tunay, Özdemi̇r Özdemi̇r, Damla Ergi̇ntürk Acar, İkbal Seza Petri̇çli̇, Şeri̇fe Suna Oğuz
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to report the gestational age (GA) and birth weight (BW) distribution of premature babies who needed treatment for retinopathy of prematurity (ROP) and to assess the timing of the treatment. Materials and methods: The records of 9008 infants who were screened for ROP were examined and 556 infants who underwent laser therapy for ROP were reviewed. Sex, GA, BW, postnatal age, and postmenstrual (PM) age at the time of laser therapy were recorded. The babies were classified as in-born (Group 1) and out-born infants (Group 2). Results: The mean GA was 27.3 weeks …
A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz
A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz
Turkish Journal of Medical Sciences
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Minor Salivary Gland Evaluation: Sjögren?S Syndrome, Sülen Sarioğlu, Ülkü Küçük, Pinar Çeti̇n, İsmai̇l Sari, Ahmet Meri̇h Bi̇rli̇k
Minor Salivary Gland Evaluation: Sjögren?S Syndrome, Sülen Sarioğlu, Ülkü Küçük, Pinar Çeti̇n, İsmai̇l Sari, Ahmet Meri̇h Bi̇rli̇k
Turkish Journal of Medical Sciences
Background/aim:1397645907We aimed to analyze the value of 3 serial sections, spaced 2001397645907μm1397645907apart,1397645907for quantification of lymphocyte and plasma cell foci in1397645907minor salivary gland biopsy (MSGB).1397645907 Materials and methods:1397645907Labial MSGBs from 69 patients with Sjögren's syndrome (SS) and scleroderma were used for this study. Each sample was prepared as 3 serial sections spaced 2001397645907μm apart.1397645907Lymphocytic and plasma cell focus score (LFS, PFS) were determined for each section, and the diagnostic results were compared to those obtained from a single section. Results: For 22 of the 69 patients, all 3 sections1397645907were scored at1397645907
Seasonal Vitamin D Status And Endothelial Function In Healthcare Workers, Özlem Hali̇loğlu, Tolga Kasaci, Di̇lek Yavuz
Seasonal Vitamin D Status And Endothelial Function In Healthcare Workers, Özlem Hali̇loğlu, Tolga Kasaci, Di̇lek Yavuz
Turkish Journal of Medical Sciences
Background/aim: Healthcare workers have long working hours indoors and are at risk of vitamin D deficiency. The aim of this study was to determine seasonal vitamin D status and its relationship with early atherosclerotic markers, endothelial function, and carotid intima-media thickness (CIMT) in healthcare workers of Marmara University Hospital, İstanbul. Materials and methods: One hundred and ninety healthy volunteer healthcare workers and 66 nonmedical volunteers of Marmara University Hospital were included in the study and 25-hydroxyvitamin D (25(OH)D), calcium, intact parathyroid hormone (PTH), endothelial function, and CIMT were measured twice during winter and summer seasons. Results: Mean vitamin D levels …