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Articles 2341 - 2370 of 4871
Full-Text Articles in Medicine and Health Sciences
The Relationship Of Breast Arterial Calcification Detected In Mammographic Examinations With Cardiovascular Diseases, Cardiovascular Risk Factors, Parity, And Breastfeeding, Kadi̇han Yalçin Şafak, Ayşegül Eratalay, Ebru Dülger İli̇ş, Nesli̇han Umarusman Tanju, Begüm Damla Şencan, Tamer Baysal
The Relationship Of Breast Arterial Calcification Detected In Mammographic Examinations With Cardiovascular Diseases, Cardiovascular Risk Factors, Parity, And Breastfeeding, Kadi̇han Yalçin Şafak, Ayşegül Eratalay, Ebru Dülger İli̇ş, Nesli̇han Umarusman Tanju, Begüm Damla Şencan, Tamer Baysal
Turkish Journal of Medical Sciences
Background/aim: We aimed to detect the incidence of breast arterial calcification (BAC) in patients that underwent mammography and to reveal the relationship of BAC with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding. Materials and methods: A total of 1195 female patients were included in this study. Cases that were positive for BAC during mammography were recorded. The relationship of BAC with age, body mass index, parity, breastfeeding, menopause, smoking, alcohol consumption, oral contraceptive use, hormone replacement therapy, and histories of hypertension (HT), diabetes mellitus (DM), coronary artery disease (CAD), and cerebral vascular diseases were investigated. Results: Overall, 97 of …
Evaluation Of Tetanus Antibody Levels In Adults In Yozgat, Turkey, Çi̇ğdem Kader, Mehmet Balci, Ayşe Erbay
Evaluation Of Tetanus Antibody Levels In Adults In Yozgat, Turkey, Çi̇ğdem Kader, Mehmet Balci, Ayşe Erbay
Turkish Journal of Medical Sciences
Background/aim: To assess the immune status against tetanus in relation to self-declared vaccination status among an adult population in Yozgat, Turkey. Methods: Questionnaires and blood specimens were collected from 267 individuals over 18 years of age in Yozgat, Turkey. Antitetanus antibodies were determined quantitatively by enzyme-linked immunosorbent assay. Results: Among the 267 subjects (mean age 43.4 ± 15.6; male:female, 133:134) 168 (62.9%) had protective level of tetanus antibody titers. There was a characteristic distribution of the tetanus antibody titers in different age groups as it dropped with increasing age. Protective immunity was obtained in 74.1% of urban and 47.9% of …
Celiac Disease In Children With Chronic Constipation, Murat Çakir, Seçi̇l Cezaroğlu, Ümi̇t Çobanoğlu
Celiac Disease In Children With Chronic Constipation, Murat Çakir, Seçi̇l Cezaroğlu, Ümi̇t Çobanoğlu
Turkish Journal of Medical Sciences
Background/aim: Chronic constipation (CC) and celiac disease (CD) are the most common conditions encountered in pediatric gastroenterology. The association of these two disorders has not been evaluated properly. We analyzed the prevalence and outcome of CD in children with CC. Materials and methods: The study included children with CC (n = 313) and healthy children (n = 990). Serum IgA and IgA antitissue transglutaminase antibodies (IgA-tTG) were studied in all subjects. Intestinal biopsy and HLA-DQ2/DQ8 typing was performed in subjects with elevated IgA-tTG. Results: Serology was positive in 8 children (2.5%) with CC and 6 children (0.6%) from the control …
The Antioxidant And Antimutagenic Activities Of Ankaferd Blood Stopper,A Natural Hemostatic Agent Used In Dentistry, Aysel Uğur, Nurdan Saraç, Di̇lek Aynur Çankal, Murat Özle
The Antioxidant And Antimutagenic Activities Of Ankaferd Blood Stopper,A Natural Hemostatic Agent Used In Dentistry, Aysel Uğur, Nurdan Saraç, Di̇lek Aynur Çankal, Murat Özle
Turkish Journal of Medical Sciences
Background/aim: This study investigated the antioxidant and antimutagenic properties of Ankaferd blood stopper (ABS), a plant-based topical hemostatic agent used in Turkey to treat external hemorrhages and bleeding during dental surgery. While previous studies have examined the antimicrobial, antiinflammatory, and anticarcinogenic properties of ABS, to our knowledge, this is the first study to report on the antioxidant and antimutagenic activities of this drug. Materials and methods: Antioxidant activity was evaluated using DPPH radical-scavenging and β-carotene-linoleic acid tests. Antimutagenic activity was assessed using the Ames Salmonella/microsome mutagenicity test with the bacterial mutant strains Salmonella typhimurium TA98 and TA100. Results: Although ABS …
Treatment Of Mixed Astigmatism: Early Clinical Outcomes With Wavelight And Technolas Excimer Lasers, Ayşe Ebru Kilavuzoğlu, Tansu Gönen, Ali̇ Riza Cenk Çelebi̇, Cemi̇le Banu Coşar Yurteri̇, Asim Bozkurt Şener
Treatment Of Mixed Astigmatism: Early Clinical Outcomes With Wavelight And Technolas Excimer Lasers, Ayşe Ebru Kilavuzoğlu, Tansu Gönen, Ali̇ Riza Cenk Çelebi̇, Cemi̇le Banu Coşar Yurteri̇, Asim Bozkurt Şener
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the results of WaveLight Allegretto Wave Eye-Q 400 Hz and Technolas 217z100 excimer lasers in the treatment of mixed astigmatism. Materials and methods: Forty-nine patients who underwent laser in situ keratomileusis for mixed astigmatism were included in this retrospective study. Twenty-eight eyes of 21 patients were treated with WaveLight and 46 eyes of 28 patients were treated with the Technolas excimer laser. The patients' visual acuities and refractive values were evaluated on postoperative day 1 and at 1 and 3 months. Results: In the WaveLight and Technolas groups, cylindrical refractive errors at month 3 were …
Enos Gene Polymorphisms In Paraffin-Embedded Tissues Of Prostate Cancer Patients, Fi̇kri̇ye Polat, Nesri̇n Turaçlar, Meral Yilmaz, Günsel Bi̇ngöl, Hasi̇be Ci̇ngi̇lli̇ Vural
Enos Gene Polymorphisms In Paraffin-Embedded Tissues Of Prostate Cancer Patients, Fi̇kri̇ye Polat, Nesri̇n Turaçlar, Meral Yilmaz, Günsel Bi̇ngöl, Hasi̇be Ci̇ngi̇lli̇ Vural
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to investigate whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in prostate cancer (PCa). Materials and methods: We examined three eNOS gene polymorphisms (T-786C promoter region, G894T, and Intron 4 VNTR 4a/b) at extracted DNAs from 50 formalin-fixed paraffin-embedded tissues of PCa patients. For the controls, blood samples obtained from 50 healthy men were studied. Genotyping of molecular variants was performed by PCR-RFLP technique. Results: We found that the TC genotype of the T-786C polymorphism was associated with PCa risk (OR: 3.325, CI: 1.350-8.188, P = 0.008). The eNOS …
Categorization Of Ureteroscopy Complications And Investigation Of Associated Factors By Using The Modified Clavien Classification System, Ercan Öğreden, Ural Oğuz, Erhan Demi̇relli̇, Erdal Benli̇, Eyüp Burak Sancak, Murat Tolga Gülpinar, Alpaslan Akbaş, Berkan Reşorlu, Ali̇ Ayyildiz, Orhan Yalçin
Categorization Of Ureteroscopy Complications And Investigation Of Associated Factors By Using The Modified Clavien Classification System, Ercan Öğreden, Ural Oğuz, Erhan Demi̇relli̇, Erdal Benli̇, Eyüp Burak Sancak, Murat Tolga Gülpinar, Alpaslan Akbaş, Berkan Reşorlu, Ali̇ Ayyildiz, Orhan Yalçin
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to review the complications of ureteroscopy (URS) by using the modified Clavien classification system (MCCS) and to investigate the factors associated with complications. Materials and methods: Data regarding 811 patients who underwent URS for ureteral calculus were analyzed. Peroperative and postoperative complications were recorded. The patients were divided into seven groups depending on the severity of the complications. The association of sex, stone size, number, and localization with each MCCS grade was also evaluated. Results: The average age was 45 years. The success of the procedure after one session was 93.5%. Complications …
Premenstrual Syndrome And Life Quality In Turkish Health Science Students, Hati̇ce Işik, Şule Ergöl, Öner Aynioğlu, Ahmet Şahbaz, Ayşe Kuzu, Müge Uzun
Premenstrual Syndrome And Life Quality In Turkish Health Science Students, Hati̇ce Işik, Şule Ergöl, Öner Aynioğlu, Ahmet Şahbaz, Ayşe Kuzu, Müge Uzun
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to investigate the incidence of PMS, risk factors affecting PMS symptoms, and life quality in health science students. Materials and methods: A total of 608 volunteer female students studying at the health campus of a state university in Turkey were included in the study. The participants were asked to fill out questionnaires on sociodemographic data, PMS symptoms, and SF-36 life quality tests. Results: The overall frequency of PMS among participants was 84.5%. The average PMS and general health SF scores were 118.34 ± 37.3 and 20.03 ± 3.72, respectively. Students who had …
Effects Of Blood Pressure And Sex On Heart-Vessel Coupling In Essential Hypertension, Changjuan Hao, Chunsong Kang, Jiping Xue, Kailing Shi, Hong Lv, Zhaojun Li
Effects Of Blood Pressure And Sex On Heart-Vessel Coupling In Essential Hypertension, Changjuan Hao, Chunsong Kang, Jiping Xue, Kailing Shi, Hong Lv, Zhaojun Li
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the impact of blood pressure and sex on heart-vessel coupling in patients with essential hypertension via ultrasound. Materials and methods: We studied 76 patients with essential hypertension (48 males and 28 females) and 65 healthy controls (33 males and 32 females). Coupling parameters were obtained using ultrasound technology combined with brachial artery blood pressure measurement. Results: The Ea and Ees were higher in the hypertension group than in the control group (P < 0.01), with no statistically significant difference in Ea/Ees between the two groups (P >0.05). After subjects were classified by sex, the Ea and Ees of males and females in the hypertension group were higher than …
Brachiobasilic Arteriovenous Fistula With Transpositionof The Basilic Vein: A Multicenter Study, Stelian Pantea, Iustinian Michael Bengulescu, Gabriela Orosan, Irina Strambu, Victor Dan Eugen Strambu
Brachiobasilic Arteriovenous Fistula With Transpositionof The Basilic Vein: A Multicenter Study, Stelian Pantea, Iustinian Michael Bengulescu, Gabriela Orosan, Irina Strambu, Victor Dan Eugen Strambu
Turkish Journal of Medical Sciences
Background/aim: The aim of this paper was to present our 3-year multicenter experience in creating a vascular access using the basilic vein. The third choice in creating vascular access is the brachiobasilic arteriovenous fistula (AVFs) with transposition of the basilic vein. Materials and methods: During 2010-2012, out of a total of 874 AVFs that were performed in our two centers, 54 were brachiobasilic fistulas (6.71%), performed on 54 patients. All surgical procedures were performed by two surgical teams, one for each center. There were no significant differences regarding the patients' age, sex, and comorbidities between the two centers. Results: We …
Evaluation Of The Relationship Between Migraine Disorder Andoral Comorbidities: Multicenter Randomized Clinical Trial, Cem Peşkersoy, Şule Peker, Ayşegül Kaya, Aycan Ünalp, Necmi̇ Gökay
Evaluation Of The Relationship Between Migraine Disorder Andoral Comorbidities: Multicenter Randomized Clinical Trial, Cem Peşkersoy, Şule Peker, Ayşegül Kaya, Aycan Ünalp, Necmi̇ Gökay
Turkish Journal of Medical Sciences
Background/aim: Although migraine is a common disorder, there is a lack of research investigating the possible relationship between migraine and oral health. The aim of the present study was to explore the relationship between temporomandibular disorders, bruxism, dental caries, periodontal status, and migraine disorder in a multicenter, parallel, case-controlled clinical study. Materials and methods: A total of 2001 participants were divided into two groups: migraineurs (nm = 998) and nonmigraineurs (nh = 1003). International Headache Society's Second Edition of International Classification of Headache Disorders and modified Migraine Disability Assessment surveys were administered to evaluate the level of migraine; a pretreatment …
Effects Of A Self-Management Educational Program On Metabolic Control In Type 2 Diabetes, Hosein Ali Sadeghian, Sri Venkata Madu, Kamal Agrawal, Aanjor Tupil Kannan, Kireet Agrawal
Effects Of A Self-Management Educational Program On Metabolic Control In Type 2 Diabetes, Hosein Ali Sadeghian, Sri Venkata Madu, Kamal Agrawal, Aanjor Tupil Kannan, Kireet Agrawal
Turkish Journal of Medical Sciences
Background/aim: India has 63 million diabetic people and the overall prevalence of diabetes in this country is 8.37%. Lifestyle modification by education is the most cost-effective strategy to have better metabolic control. The aim of this study was to investigate the effects of a self-management educational program on control of type 2 diabetes Materials and methods: It was a randomized controlled interventional study conducted among 306 patients with type 2 diabetes mellitus attending the Diabetic Clinic at G.T.B. Hospital, Delhi, from March 2010 to May 2013. The intervention was in the form of group education based on a self-management program, …
Investigation Of Enteropathogenic Escherichia Coli And Shiga Toxin-Producing Escherichia Coli Associated With Hemolytic Uremic Syndrome In İzmir Province, Turkey, Eli̇f Bozçal, Gürkan Yi̇ği̇ttürk, Ataç Uzel, Sabi̇re Şöhret Aydemi̇r
Investigation Of Enteropathogenic Escherichia Coli And Shiga Toxin-Producing Escherichia Coli Associated With Hemolytic Uremic Syndrome In İzmir Province, Turkey, Eli̇f Bozçal, Gürkan Yi̇ği̇ttürk, Ataç Uzel, Sabi̇re Şöhret Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to investigate Shiga toxin-producing Escherichia coli (STEC) and enteropathogenic Escherichia coli (EPEC) strains originating from diarrheagenic patients. Materials and methods: A total of 102 patients with diarrhea between October 2012 and January 2013 were enrolled in this study. Multiplex and standard polymerase chain reactions were performed to detect and distinguish STEC and EPEC strains. O serotyping of EPEC was carried out by monovalent antisera. The O and H serotyping of STEC strains was performed at the Refik Saydam Institute, Ankara. Results: A total of 5 (3.42%) strains were identified as STEC, and 3 …
Intravitreal Bevacizumab For Retinopathy Of Prematurity In Infants Ineligible For Laser Therapy, Ahmet Murad Hondur, Mehmet Özgür Çubuk, Zühal Özen Tunay, Hati̇ce Tuba Atalay, Özdemi̇r Özdemi̇r, İkbal Seza Petri̇çli̇, İhsan Gökhan Güreli̇k
Intravitreal Bevacizumab For Retinopathy Of Prematurity In Infants Ineligible For Laser Therapy, Ahmet Murad Hondur, Mehmet Özgür Çubuk, Zühal Özen Tunay, Hati̇ce Tuba Atalay, Özdemi̇r Özdemi̇r, İkbal Seza Petri̇çli̇, İhsan Gökhan Güreli̇k
Turkish Journal of Medical Sciences
Background/aim: To evaluate refractive and strabismic results and the efficacy of intravitreal bevacizumab in retinopathy of prematurity (ROP) ineligible for laser therapy. Materials and methods: Thirty-nine eyes of 20 consecutive infants with high-risk prethreshold ROP (11 infants with Zone I and 9 infants with Zone II disease) who were ineligible for laser therapy due to systemic and/or ocular conditions were treated with intravitreal bevacizumab. Recurrent retinopathy was treated with laser ablation. The final follow-up examination was performed at 29.8 ± 6.0 months of corrected age. Results: All eyes responded to the initial treatment with intravitreal bevacizumab. ROP recurred in 8 …
Sevoflurane Versus Propofol For Electroconvulsive Therapy: Effects On Seizure Parameters, Anesthesia Recovery, And The Bispectral Index, Melekşah Pekel, Nadi̇de Aysun Postaci, İsmai̇l Aytaç, Derya Karasu, Hüseyi̇n Keleş, Özlem Şen, Bayazi̇t Di̇kmen, Erol Göka
Sevoflurane Versus Propofol For Electroconvulsive Therapy: Effects On Seizure Parameters, Anesthesia Recovery, And The Bispectral Index, Melekşah Pekel, Nadi̇de Aysun Postaci, İsmai̇l Aytaç, Derya Karasu, Hüseyi̇n Keleş, Özlem Şen, Bayazi̇t Di̇kmen, Erol Göka
Turkish Journal of Medical Sciences
Background/aim: In this prospective randomized cross-over study we compare the effects of sevoflurane versus propofol for electroconvulsive therapy (ECT) anesthesia. Materials and methods: Twenty four patients (ASA I-III, 18-65 years old) receiving ECT three times per week were included. Anesthesia was induced with either propofol (0.75 mg/kg iv) or 5% sevoflurane in 100% oxygen. Consecutive ECT sessions followed a 2 × 2 crossover design and a 2-day washout period until the 10th ECT. Intravenous succinylcholine (1 mg/kg) was administered while bispectral index (BIS) values were ≤60%. Results: Electromyogram and electroencephalogram seizure duration, postictal suppression index, BIS values, mean arterial blood …
Levels Of Nitric Oxide, Asymmetric Dimethyl Arginine, Symmetric Dimethyl Arginine,And L-Arginine In Patients With Obsessive-Compulsive Disorder, Enver Demi̇rel Yilmaz, Mehmet Fati̇h Üstündağ, Ali̇ Görkem Gençer, Yüksel Kivrak, Özge Ünal, Mustafa Bi̇li̇ci̇
Levels Of Nitric Oxide, Asymmetric Dimethyl Arginine, Symmetric Dimethyl Arginine,And L-Arginine In Patients With Obsessive-Compulsive Disorder, Enver Demi̇rel Yilmaz, Mehmet Fati̇h Üstündağ, Ali̇ Görkem Gençer, Yüksel Kivrak, Özge Ünal, Mustafa Bi̇li̇ci̇
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate and compare to healthy controls the variations in the levels of nitric oxide (NO), asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-arginine levels in patients with obsessive-compulsive disorder (OCD). Materials and methods: We enrolled 30 patients with OCD and 30 healthy controls in the study consecutively. Diagnostic interviews of all participants were conducted with the Structured Clinical Interview for Axis I Disorders (SCID-I), and sociodemographic data of the participants were recorded. Patients scoring 10 points or more on the Yale-Brown Obsessive-Compulsive Scale were enrolled in the study. Results: The NO levels of patients …
Nf-?? And Sod Expression In Preeclamptic Placentas, Abraham Silva Carmona, Hugo Mendieta Zeron
Nf-?? And Sod Expression In Preeclamptic Placentas, Abraham Silva Carmona, Hugo Mendieta Zeron
Turkish Journal of Medical Sciences
Background/aim: Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-?β) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background. Materials and methods: Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-?β and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression …
The Effect Of Addition Of Ketamine To Lidocaine On Postoperative Pain In Rhinoplasties, Mukadder Şanli, Nurçi̇n Gülhaş, Bi̇lge Türk Bi̇len, Gülay Erdoğan Kayhan, Muharrem Uçar, Ahmet Hamdi̇ Ayteki̇n, Sai̇m Yoloğlu
The Effect Of Addition Of Ketamine To Lidocaine On Postoperative Pain In Rhinoplasties, Mukadder Şanli, Nurçi̇n Gülhaş, Bi̇lge Türk Bi̇len, Gülay Erdoğan Kayhan, Muharrem Uçar, Ahmet Hamdi̇ Ayteki̇n, Sai̇m Yoloğlu
Turkish Journal of Medical Sciences
Background/aim: The objective of this study was to examine the effect of addition of subanesthetic doses of ketamine to an epinephrine-lidocaine solution on postoperative pain, analgesic use, and patient comfort during rhinoplasties. Materials and methods: Ninety patients were randomly divided into three groups: Group L, lidocaine with epinephrine; Group K, lidocaine with epinephrine plus ketamine; and Group S (control group), physiological saline solution with epinephrine. The local anesthetic solution was injected as preincisionally with intranasal submucosal infiltration following induction of general anesthesia. We evaluated visual pain score, analgesic demand, Wilson sedation score, and antiemetic demand at 5, 15, and 30 …
Complications Of Tracheobronchial Foreign Bodies, Bayram Altuntaş, Yener Aydin, Ati̇la Eroğlu
Complications Of Tracheobronchial Foreign Bodies, Bayram Altuntaş, Yener Aydin, Ati̇la Eroğlu
Turkish Journal of Medical Sciences
Background/aim: Tracheobronchial foreign bodies may cause several complications in the respiratory system. We aimed to present the complications of tracheobronchial foreign bodies. Materials and methods: Between January 1990 and March 2015, 813 patients with suspected tracheobronchial foreign body aspiration were hospitalized in our department. Patients with complications related to foreign bodies in airways were included in this study. We retrospectively evaluated the records of patients according to symptoms, foreign body type, localizations, and complications. Results: A foreign body was found in 701 of 813 patients (86.2%). Complications related to foreign bodies settled in airways were seen in 96 patients (13.7%). …
Long-Term Assessment Of Coronary Care Unit Patient Profile And Outcomes: Analyses Of The 12-Years Patient Records, Selami̇ Doğan, Hüseyi̇n Dursun, Hüseyi̇n Can, Hülya Elli̇dokuz, Dayi̇mi̇ Kaya
Long-Term Assessment Of Coronary Care Unit Patient Profile And Outcomes: Analyses Of The 12-Years Patient Records, Selami̇ Doğan, Hüseyi̇n Dursun, Hüseyi̇n Can, Hülya Elli̇dokuz, Dayi̇mi̇ Kaya
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the patient profile, treatment, and outcomes of a coronary care unit (CCU) by retrospective screening of 12-year patient records. Materials and methods: The data of 13,463 patients admitted to the CCU of a tertiary referral hospital between 1 January 1997 and 30 June 2008 were collected. The patients were assessed with respect to demographics, admission diagnosis, treatment, and outcomes. Results: The mean age of patients was 61 ± 13 years (66.7%, male). While the diagnosis of acute coronary syndrome (ACS) accounted for 65%, the rate of ST elevation myocardial infarction (STEMI) …
Evaluation Of Behavioral Problems In Patients With Monosymptomaticnocturnal Enuresis: A Prospective Controlled Trial, Mehmet Akyüz, Orhan Koca, Bi̇lal Karaman, Zeynep Yeşi̇m Özcan, Meti̇n İshak Öztürk, Musab Ali̇ Kutluhan, Muhammet İhsan Karaman
Evaluation Of Behavioral Problems In Patients With Monosymptomaticnocturnal Enuresis: A Prospective Controlled Trial, Mehmet Akyüz, Orhan Koca, Bi̇lal Karaman, Zeynep Yeşi̇m Özcan, Meti̇n İshak Öztürk, Musab Ali̇ Kutluhan, Muhammet İhsan Karaman
Turkish Journal of Medical Sciences
Background/aim: The aim of the present study was to evaluate the behavioral and emotional patterns of patients with nocturnal enuresis (NE) and compare them with those of healthy subjects. Materials and methods: Thirty-eight children and adolescents with monosymptomatic NE who were admitted to our hospital's pediatric and urologic outpatient clinics and 46 age-matched, healthy subjects were enrolled in this study. To compare behavioral patterns in these patients, the Child Behavior Checklist (CBCL) was used. Patients' ages, occupations, educational, and socioeconomic status, and mothers' age at delivery were compared in the two groups. One-way ANOVA was used for statistical analysis. Results: …
Potential Drug?Drug Interactions In A Medical Intensive Care Unit Of A University Hospital, Medi̇ne Gülçebi̇ İdri̇z Oğlu, Esra Küçüki̇brahi̇moğlu, Ati̇la Karaalp, Özlem Sarikaya, Mahluga Demirkapu, Fi̇li̇z Onat, Mehmet Zafer Gören
Potential Drug?Drug Interactions In A Medical Intensive Care Unit Of A University Hospital, Medi̇ne Gülçebi̇ İdri̇z Oğlu, Esra Küçüki̇brahi̇moğlu, Ati̇la Karaalp, Özlem Sarikaya, Mahluga Demirkapu, Fi̇li̇z Onat, Mehmet Zafer Gören
Turkish Journal of Medical Sciences
Background/aim: Drug-drug interactions (DDIs) can impact patient safety. Occurrence of clinically important DDIs is higher for intensive care unit (ICU) patients. This observational study aimed to evaluate the potential DDIs in medical ICU patients of a university hospital. Materials and methods: The Medical Pharmacology Department organized consultation reports for ICU patients in order to detect the DDIs. To focus on clinically important DDIs, interactions in the C, D, or X risk rating categories of the Lexi-Interact online database were analyzed. Frequency and clinical risk rating categories of DDIs were detected. Relationship between number of prescriptions and DDIs were assessed. The …
Evaluation Of The Gastrointestinal Findings Of Nodulocystic Acnepatients During Systemic Isotretinoin Therapy, Duru Tabanlioğlu Onan, Burcu Hazar Tantoğlu, Nuran Alli, Seçi̇l Özkan, Ufuk Samsar, Hasan Tankut Köseoğlu, Refi̇ka Ferda Artüz
Evaluation Of The Gastrointestinal Findings Of Nodulocystic Acnepatients During Systemic Isotretinoin Therapy, Duru Tabanlioğlu Onan, Burcu Hazar Tantoğlu, Nuran Alli, Seçi̇l Özkan, Ufuk Samsar, Hasan Tankut Köseoğlu, Refi̇ka Ferda Artüz
Turkish Journal of Medical Sciences
Background/aim: Systemic isotretinoin treatment is an effective treatment modality for nodulocystic acne, the clinical use of which has been associated with reports of adverse events. We conducted a prospective study with the aim of determining the possible gastrointestinal and laboratory findings of nodulocystic acne patients during systemic isotretinoin treatment. Materials and methods: Seventy patients with nodulocystic acne completed the study. During the monthly follow-up visits, liver function tests and lipid profiles of the patients were evaluated and gastrointestinal system complaints were examined. Results: We recorded a significant elevation in liver function tests and lipid profiles of the patients, the most …
Prospects Of Curcumin As An Additive In Storage Solutions: A Study On Erythrocytes, Soumya Ravikumar, Carl Hsieh, Vani Rajashekharaiah
Prospects Of Curcumin As An Additive In Storage Solutions: A Study On Erythrocytes, Soumya Ravikumar, Carl Hsieh, Vani Rajashekharaiah
Turkish Journal of Medical Sciences
Background/aim: Curcumin, a naturally occurring antioxidant, shows a wide variety of medicinal properties. The possibility of utilizing curcumin as an additive in storage solutions of blood has not been explored. The purpose of this study was to analyze the effect of curcumin on erythrocytes during storage. Materials and methods: Blood obtained from rats was stored (4 °C) for 20 days in citrate-phosphate-dextrose-adenine-1 solution. Samples were divided into four groups: 1) Controls; 2) Curcumin 10 mM; 3) Curcumin 30 mM; and 4) Curcumin 60 mM. Every fifth day, hemoglobin, superoxide, antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px)), lipid peroxidation …
Evaluation Of Brain Perfusion In Alzheimer Disease With Perfusion Computed Tomography And Comparison To Elderly Patient Without Dementia, Tüli̇n Yildirim, Başak Karakurum Göksel, Şenay Demi̇r, Nai̇me Tokmak, Meli̇ha Tan
Evaluation Of Brain Perfusion In Alzheimer Disease With Perfusion Computed Tomography And Comparison To Elderly Patient Without Dementia, Tüli̇n Yildirim, Başak Karakurum Göksel, Şenay Demi̇r, Nai̇me Tokmak, Meli̇ha Tan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to evaluate perfusion computed tomography (PCT) findings in patients with Alzheimer disease and to compare them with those of patients without dementia. Materials and methods: PCT was performed in 35 patients: 20 with Alzheimer disease (mean age, 69.7 ± 5.5 years) and 15 control subjects (mean age, 67.5 ± 3.5 years). Control subjects were elderly individuals with no cognitive problems who were admitted with headaches. All PCT examinations were performed on a 4-slice CT unit. The PCT analysis software program was used to calculate regional cerebral blood flow (rCBF), regional cerebral blood volume …
The Incidence Of 18f-Fdg Pet/Ct Thyroid Incidentalomas Andthe Prevalence Of Malignancy: A Prospective Study, Mi̇ne Şencan Eren, Özhan Özdoğan, Arzu Gedi̇k, Mehmet Ceylan, Meri̇h Güray Durak, Mustafa Seçi̇l, Mehmet Ali̇ Koçdor, Abdurrahman Çömlekçi̇, Hati̇ce Durak
The Incidence Of 18f-Fdg Pet/Ct Thyroid Incidentalomas Andthe Prevalence Of Malignancy: A Prospective Study, Mi̇ne Şencan Eren, Özhan Özdoğan, Arzu Gedi̇k, Mehmet Ceylan, Meri̇h Güray Durak, Mustafa Seçi̇l, Mehmet Ali̇ Koçdor, Abdurrahman Çömlekçi̇, Hati̇ce Durak
Turkish Journal of Medical Sciences
Background/aim: To determine the prevalence of malignancy in thyroid incidentalomas (TIs) detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Materials and methods: 18F-FDG PET/CT images were evaluated prospectively for the presence of thyroid uptake. The patients with a TI were evaluated by an endocrinologist according to the predefined diagnostic algorithm. The final diagnosis was obtained clinically and/or by pathology. Results: TI was detected in 4.2% of 4204 patients. A malignant thyroid nodule was diagnosed in 29% and 33% of the focal and diffuse-focal uptake groups, respectively. However, no malignancy was detected in the diffuse uptake group. The standardized …
Three-Dimensional Cephalometric Norms Of Turkish Cypriots Using Cbctimages Reconstructed From A Volumetric Rendering Program In Vivo, Levent Vahdettin, Seçi̇l Aksoy, Ulaş Öz, Kaan Orhan
Three-Dimensional Cephalometric Norms Of Turkish Cypriots Using Cbctimages Reconstructed From A Volumetric Rendering Program In Vivo, Levent Vahdettin, Seçi̇l Aksoy, Ulaş Öz, Kaan Orhan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to create a database of 3D cephalometric measurements of Turkish Cypriot patients using a 3D rendering software program. Materials and methods: The study population comprised 121 subjects who had undergone cone beam CT imaging (CBCT). Invivo 5.1 software was used to generate cephalograms from the CBCT dataset that were then linked to the 3D hard-tissue surface representations. In total, 38 angular and 28 linear widely used measurements were recorded. Results: The results demonstrated that males had significantly larger mean values than females for all linear measurements, except for dentoalveolar parameters (P < 0.05). Additionally, significant differences were found in most of the mandibular anteroposterior and vertical measurements, especially SNB, GoGn/SN, FMA, and MP/SN, between the sexes (P < 0.05). Conclusion: This is the first population-based study to focus solely on Turkish Cypriots' craniofacial anatomy and orthodontic characteristics. The present findings will produce 3D cephalometric normative data for the Cypriot population and will be valuable for oral and maxillofacial surgeons and orthodontists in Cyprus, the UK, Australia, Turkey, and other European countries who treat a large number of Turkish Cypriot patients.
1h-Magnetic Resonance Spectroscopy In First Episode And Chronic Schizophrenia Patients, Duygu Kirtaş, Ruki̇ye Fi̇li̇z Karadağ, Meli̇ke Ceyhan Balci Şengül, Yilmaz Kiroğlu
1h-Magnetic Resonance Spectroscopy In First Episode And Chronic Schizophrenia Patients, Duygu Kirtaş, Ruki̇ye Fi̇li̇z Karadağ, Meli̇ke Ceyhan Balci Şengül, Yilmaz Kiroğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to compare metabolite levels of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate gyrus (ACG), thalamus, and hippocampus in patients with chronic schizophrenia (CSPs) and first psychotic episode patients (FEPs) by the use of magnetic resonance spectroscopy (MRS). Materials and methods: Thirty CSPs, 20 FEPs, and 30 healthy subjects participated in this study. N-Acetylaspartate (NAA), creatine, choline (Cho), and myoinositol levels of the DLPFC, ACG, thalamus, and hippocampus were measured by 1H-MRS. Results: It was determined that the NAA/Cho ratio was lower in both the FEPs and CSPs than the healthy controls in the …
Pacaha Inhibits Proliferation Of Human Cancer Cells In Vitro, Sali̇ha Ekşi̇, Nebahat Ejder, Fati̇h Yilmaz, Ayşe Ertürk, Cemal Sandalli
Pacaha Inhibits Proliferation Of Human Cancer Cells In Vitro, Sali̇ha Ekşi̇, Nebahat Ejder, Fati̇h Yilmaz, Ayşe Ertürk, Cemal Sandalli
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the antiproliferative and cytotoxic effects of a newly synthesized molecule named paracetamol acetohydroxamic acid (PaCaHa) on human neoplastic cell lines. Materials and methods: A549, CRL 2923, HeLa, and ARPE were treated with various concentrations of PaCaHa and DMSO (vehicle control). The cytotoxic/cytostatic effects of PaCaHa were determined after a 24-h incubation period and compared to the DMSO control. The cytotoxic and antiproliferative effects were determined by the trypan blue dye exclusion and MTT methods. Results: A higher susceptibility to PaCaHA was found in CRL 2923 and HeLa cells, while A549 and …
Determination Of Virulence And Multidrug Resistance Genes With Polymerase Chain Reaction Method In Vancomycin-Sensitive And -Resistant Enterococci Isolated From Clinical Samples*, Şükran Saba Çopur, Fi̇kret Şahi̇n, Juli̇de Sedef Göçmen
Determination Of Virulence And Multidrug Resistance Genes With Polymerase Chain Reaction Method In Vancomycin-Sensitive And -Resistant Enterococci Isolated From Clinical Samples*, Şükran Saba Çopur, Fi̇kret Şahi̇n, Juli̇de Sedef Göçmen
Turkish Journal of Medical Sciences
Background/aim: Enterococci play an important role in nosocomial infections. Therefore, this study investigates multidrug resistance (MDR)1 gene areas in the pathogenicity of enterococci and virulence genes in both vancomycin-sensitive enterococci (VSE) and vancomycin-resistant enterococci (VRE) strains. Materials and methods: Virulence genes and MDR genes of enterococci were investigated by polymerase chain reaction (PCR). Results: We evaluated a total of 116 isolates, 93 being VRE and 23 being VSE. In this study, 95.6% of VRE (n = 93) were Enterococcus faecium (n = 89) and 4.3% were E. faecalis (n = 4), while 17.4% of VSE (n = 23) were E. …