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Articles 2311 - 2340 of 4871
Full-Text Articles in Medicine and Health Sciences
Initial Experience With Delivery Of Palliative Care To Terminal Cancer Patients, Mustafa Süren, İsmai̇l Okan, Zi̇ya Kaya, Serkan Karaman, Semi̇h Arici, Mevlüt Çömlekçi̇, Murat Ayan, Mehmet Esen, Serkan Doğru, Aynur Şahi̇n, Tuğba Karaman
Initial Experience With Delivery Of Palliative Care To Terminal Cancer Patients, Mustafa Süren, İsmai̇l Okan, Zi̇ya Kaya, Serkan Karaman, Semi̇h Arici, Mevlüt Çömlekçi̇, Murat Ayan, Mehmet Esen, Serkan Doğru, Aynur Şahi̇n, Tuğba Karaman
Turkish Journal of Medical Sciences
No abstract provided.
Distribution Of Ldl Subgroups In Patients With Hyperlipidemia, Ebru Taylan, Emi̇ne Pinar Tuncel
Distribution Of Ldl Subgroups In Patients With Hyperlipidemia, Ebru Taylan, Emi̇ne Pinar Tuncel
Turkish Journal of Medical Sciences
Background/aim: Low-density lipoproteins (LDLs) have been shown to be a major risk factor for coronary artery disease. Multiple distinct subspecies have been identified among LDL particles on the basis of differences in size, density, and chemical composition. Particles with a diameter of
Management Of Hyperbilirubinemia In Preterm Infants In Turkey, Ni̇lüfer Güzoğlu, Ümi̇t Ayşe Tandircioğlu, Di̇dem Ali̇efendi̇oğlu
Management Of Hyperbilirubinemia In Preterm Infants In Turkey, Ni̇lüfer Güzoğlu, Ümi̇t Ayşe Tandircioğlu, Di̇dem Ali̇efendi̇oğlu
Turkish Journal of Medical Sciences
Background/aim: Prematurity is a significant risk factor for developing unconjugated hyperbilirubinemia. This study investigated the current approach to managing hyperbilirubinemia in preterm newborns in Turkey. Materials and methods: A study-specific questionnaire on the management of jaundice in preterm infants was sent to 100 level III neonatal intensive care units in Turkey. Results: Responses were obtained from 84 centers from all regions of Turkey. Of the centers, 75.3% used the Turkish Neonatology Society guidelines for deciding to start phototherapy, and 24.7% used different guidelines. The monitoring of bilirubin varied among the participants. Of the participants, 53.6% believed that prophylactic phototherapy was …
The Effect Of Enteral Immunonutrition In Upper Gastrointestinalsurgery For Cancer: A Prospective Study, Seli̇m Yi̇ği̇t Yildiz, Murat Burç Yazicioğlu, Çağri Ti̇ryaki̇, Ali̇ Çi̇ftçi̇, Zehra Boyacioğlu, Mehmet Özyildiz, Murat Coşkun, Özkan Subaşi
The Effect Of Enteral Immunonutrition In Upper Gastrointestinalsurgery For Cancer: A Prospective Study, Seli̇m Yi̇ği̇t Yildiz, Murat Burç Yazicioğlu, Çağri Ti̇ryaki̇, Ali̇ Çi̇ftçi̇, Zehra Boyacioğlu, Mehmet Özyildiz, Murat Coşkun, Özkan Subaşi
Turkish Journal of Medical Sciences
Background/aim: Enteral feeding and immunonutrition (ImN) have been shown to be associated with a number of favorable effects in patients undergoing cancer surgery. In this prospective study, we aimed to assess the perioperative use of enteral immunonutrition in patients undergoing radical gastrointestinal surgery for malignancy. Materials and methods: Forty-one patients with malignancy were included in this study and were randomized into one of the two following nutritional strategies: enteral only (EN) or enteral with enteral immunonutrition (ENIN). These regimens were followed for 7 days perioperatively by all patients. Nutritional parameters and postoperative morbidity, mortality, and length of hospital stay (LHS) …
Evaluation And Identification Of Idua Gene Mutations In Turkishpatients With Mucopolysaccharidosis Type I, Nazente Atçeken, Riza Köksal Özgül, Di̇dem Yücel Yilmaz, Ayşegül Tokatli, Turgay Coşkun, Hati̇ce Serap Si̇vri̇, Ali̇ Dursun, Mehmet Karaca
Evaluation And Identification Of Idua Gene Mutations In Turkishpatients With Mucopolysaccharidosis Type I, Nazente Atçeken, Riza Köksal Özgül, Di̇dem Yücel Yilmaz, Ayşegül Tokatli, Turgay Coşkun, Hati̇ce Serap Si̇vri̇, Ali̇ Dursun, Mehmet Karaca
Turkish Journal of Medical Sciences
Background/aim: This study aimed to identify IDUA gene mutations in Turkish patients morphologically (phenotypic) diagnosed with MPS type I. It also sought to discuss the possible effects of detected mutations on alpha-L-iduronidase enzyme function based on current knowledge. Materials and methods: Genetic analysis was carried out in 15 patients using direct DNA sequencing. Moreover, segregation analysis was performed among family members to predict the pathogenic effect of novel mutations, and computational programs were used to predict their functional impact. Results: Nine different mutations (c.494-1G>A, c.793-6C>G, c.793-5C>A, p.M1L, p.Y64X, p.A327P, p.W402X, p.P533L, and p.R628X) were identified. Computational analysis …
The Role Of Baseline Ga-68 Dotatate Positron Emission Tomography/Computed Tomography In The Prediction Of Response To Fixed-Dose Peptide Receptor Radionuclide Therapy With Lu-177 Dotatate*, Çi̇ğdem Soydal, Ahmet Peker, Elgi̇n Özkan, Nuri̇ye Özlem Küçük, Kemal Meti̇n Kir
The Role Of Baseline Ga-68 Dotatate Positron Emission Tomography/Computed Tomography In The Prediction Of Response To Fixed-Dose Peptide Receptor Radionuclide Therapy With Lu-177 Dotatate*, Çi̇ğdem Soydal, Ahmet Peker, Elgi̇n Özkan, Nuri̇ye Özlem Küçük, Kemal Meti̇n Kir
Turkish Journal of Medical Sciences
Background/aim: To describe the role of baseline gallium (Ga)-68 DOTATATE positron emission tomography (PET)/computed tomography (CT) in the prediction of the response to peptide receptor radionuclide therapy (PRRT) using lutetium (Lu)-177 DOTATATE. Materials and methods: Analysis was made of baseline Ga-68 DOTATATE PET/CT images of 29 patients (17 females and 12 males; mean age: 50.7 ± 14.6 years) with metastatic neuroendocrine tumors who received PRRT with Lu-177 DOTATATE. Maximum standardized uptake values (SUVmax) of reference lesions and their ratios to physiological uptake organs were calculated. The relationship between these values and the radiological response was analyzed. Results: Partial response was …
Posterior Laminoforaminotomy In The Treatment Of Lateralcervical Herniated Disc And Foraminal Stenosis, Hakan Yilmaz, Ali̇ Riza Ertürk, Ayşe Karataş, İbrahi̇m Burak Atci, Alaetti̇n Yurt
Posterior Laminoforaminotomy In The Treatment Of Lateralcervical Herniated Disc And Foraminal Stenosis, Hakan Yilmaz, Ali̇ Riza Ertürk, Ayşe Karataş, İbrahi̇m Burak Atci, Alaetti̇n Yurt
Turkish Journal of Medical Sciences
Background/aim: Posterior cervical laminoforaminotomy is an effective surgical treatment in selected cases of cervical radiculopathy caused by posterolateral herniated discs or foraminal stenosis. The aim of the present study was to evaluate the surgical techniques, rates of complications, long-term outcomes, advantages, and disadvantages of keyhole foraminotomy retrospectively. Materials and methods: Keyhole foraminotomy was performed in 83 patients. In 51 patients (61.5%) soft disc herniation was removed, and in 32 of them (38.5%) osteophytes were evident. The clinical data were evaluated according to Odom's criteria, and the mean follow-up time was 6 months. Results: Postoperative results were classed as excellent in …
Common Variable Immunodeficiency In Adults Requires Reserved Protocols For Long-Term Follow-Up, Ahmet Zafer Çalişkaner, İsmai̇l Rei̇sli̇, Şevket Arslan, Ramazan Uçar, Hüseyi̇n Ataseven, Nedi̇m Yilmaz Selçuk
Common Variable Immunodeficiency In Adults Requires Reserved Protocols For Long-Term Follow-Up, Ahmet Zafer Çalişkaner, İsmai̇l Rei̇sli̇, Şevket Arslan, Ramazan Uçar, Hüseyi̇n Ataseven, Nedi̇m Yilmaz Selçuk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to establish follow-up protocols for adult patients with common variable immunodeficiency (CVID) in a recently founded adult immunology clinic in the Central Anatolia Region of Turkey, where a clinical immunology center for adults was not available previously. Materials and methods: A total of 25 patients with CVID aged 18 years and older were included in this study. The file format consisted of 13 pages and was developed for the purpose of the study. Separate sections were designated for identity information, medical history, disease course, previous and current laboratory and imaging studies, follow-up plans, …
Is Silicone Stent Insertion A Clinically Useful Option For Tracheobronchomalacia?, Levent Dalar, Seda Tural Önür, Cengi̇z Özdemi̇r, Si̇nem Nedi̇me Sökücü, Ahmet Levent Karasulu, Sedat Altin
Is Silicone Stent Insertion A Clinically Useful Option For Tracheobronchomalacia?, Levent Dalar, Seda Tural Önür, Cengi̇z Özdemi̇r, Si̇nem Nedi̇me Sökücü, Ahmet Levent Karasulu, Sedat Altin
Turkish Journal of Medical Sciences
Background/aim: Tracheobronchomalacia (TBM) leads to the obstruction of expiratory airflow and interference with secretion clearance. Stabilization of the airway wall using a silicon stent or laser coagulation of the posterior wall may be treatment options.1397645907This study aimed to retrospectively analyze which interventional bronchoscopic method could be used to provide airway stabilization and gain control of symptoms and for whom this method could be used. Materials and methods: Fifteen patients who had received treatment in our interventional pulmonology unit were analyzed. We analyzed the techniques used, stent duration, complications, and long-term treatment success retrospectively. Results: Stents were used in 10 patients: …
Physical Activity And Physical Fitness In Obese, Overweight, And Normal-Weight Children, Juozas Raistenskis, Aurelija Sidlauskiene, Birute Strukcinskiene, Serpi̇l Uğur Baysal, Raimondas Buckus
Physical Activity And Physical Fitness In Obese, Overweight, And Normal-Weight Children, Juozas Raistenskis, Aurelija Sidlauskiene, Birute Strukcinskiene, Serpi̇l Uğur Baysal, Raimondas Buckus
Turkish Journal of Medical Sciences
Background/aim: The aim was to assess the differences between physical activity and physical fitness in obese, overweight, and normal-weight children. Materials and methods: The cross-sectional study was accomplished using cluster sampling method at 3 Lithuanian schools. An analysis of anthropometric data for 532 Lithuanian children was performed. Height, weight, waist and hip circumferences, and skinfold thickness were measured. Body mass index, waist-to-hip ratio, and body fat percentage were calculated. The Youth Physical Activity Questionnaire and a 6-min walk test (6MWT) were administered to evaluate physical activity and physical fitness. Maximal oxygen consumption was calculated to assess the children's aerobic capacity. …
The Prevalence Of Tularemia In Occupational Groups That Have Contact With Animals, Fati̇h Büyük, Özgür Çelebi̇, Eli̇f Çeli̇k, Beki̇r Çelebi̇, Selçuk Kiliç, Ali̇ye Gülmez Sağlam, Doğan Akça, Mehmet Doğanay, Sali̇h Otlu, Mi̇tat Şahi̇n
The Prevalence Of Tularemia In Occupational Groups That Have Contact With Animals, Fati̇h Büyük, Özgür Çelebi̇, Eli̇f Çeli̇k, Beki̇r Çelebi̇, Selçuk Kiliç, Ali̇ye Gülmez Sağlam, Doğan Akça, Mehmet Doğanay, Sali̇h Otlu, Mi̇tat Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: The aim of the current study was to investigate the presence of antibodies against Francisella tularensis in individuals in different occupations that have contact with animals in the Kars region of northeastern Turkey. Materials and methods: A total of 201 blood samples specifically including 103 farmers, 45 clinical veterinarians, 42 butchers, and 11 hunters were analyzed. The results of the study were reported in relation to some sociodemographic features (age, sex, occupation, and experience) of the volunteers. The presence of antibodies was determined by a microagglutination (MA) test. In addition, positive sera were confirmed using an ELISA kit. Results: …
Review Of 306 Evisceration Surgeries Performed Between 2005 And 2013, Özgür Balta, Uğur Acar, Fatma Akbaş Kocaoğlu, Fi̇rdevs Örnek
Review Of 306 Evisceration Surgeries Performed Between 2005 And 2013, Özgür Balta, Uğur Acar, Fatma Akbaş Kocaoğlu, Fi̇rdevs Örnek
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to evaluate the reasons for eye evisceration surgeries performed from 2005 to 2013 in our clinic. Materials and methods: The medical records of patients who underwent evisceration surgery over the past 9 years were retrospectively evaluated. Detailed data were reviewed, with a focus on the first precipitating factor for evisceration. Results: Of the 306 patients who underwent evisceration surgery in the studied period, 111 (36.27%) were female (with a mean age of 41.56 ± 21.38 years) and 195 (63.73%) were male (with a mean age of 37.76 ± 21.92 years). The most …
Amniotic Membrane Transplantation In Bacterial And Herpetic Stromal Keratitis, Yeşi̇m Altay, Sema Tamer, Ayşe Burcu, Özgür Balta
Amniotic Membrane Transplantation In Bacterial And Herpetic Stromal Keratitis, Yeşi̇m Altay, Sema Tamer, Ayşe Burcu, Özgür Balta
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to describe the results of amniotic membrane transplantation (AMT) in patients with bacterial and herpetic stromal keratitis. Materials and methods: This was a retrospective chart review study including 42 patients with herpetic keratitis (group 1) and 42 patients with bacterial keratitis (group 2). AMT was performed in addition to antimicrobial therapy. Topical steroids were administered after surgery. The outcome parameters evaluated were epithelialization time, decrease of stromal inflammation, and uncorrected visual acuity (UCVA). Results: The average age of our patients was 55.85 ± 19.07 years, and average follow-up was 14.70 ± 11.75 months. …
The Role Of 18f-Fdg Pet-Ct In The Detection Of Unknown Primary Malignancy: A Retrospective Study, Olga Yaylali, Fatma Suna Kiraç, Doğangün Yüksel
The Role Of 18f-Fdg Pet-Ct In The Detection Of Unknown Primary Malignancy: A Retrospective Study, Olga Yaylali, Fatma Suna Kiraç, Doğangün Yüksel
Turkish Journal of Medical Sciences
Background/aim: This study aimed to retrospectively evaluate the role of 18F-FDG PET/CT imaging in the detection of unknown primary tumor sites in patients with a suspicious malignancy. Materials and methods: We retrospectively examined the 18F-FDG PET/CT images of 50 unknown primary malignancy patients. The malignancy of the lesions with increased 18F-FDG uptake on PET images was defined by interpreting the nondiagnostic CT images that were obtained with the PET study. The primary tumor site was decided according to the combined PET/CT findings, and the results were subsequently confirmed with a histopathological examination. Results: Fifty patients (29 M; 21 F) aged …
Glycemic Index Values Of Monofloral Turkish Honeys And The Effect Oftheir Consumption On Glucose Metabolism*, Ali̇ Ti̇muçi̇n Atayoğlu, Meltem Soylu, Si̇bel Si̇li̇ci̇, Neri̇man İnanç
Glycemic Index Values Of Monofloral Turkish Honeys And The Effect Oftheir Consumption On Glucose Metabolism*, Ali̇ Ti̇muçi̇n Atayoğlu, Meltem Soylu, Si̇bel Si̇li̇ci̇, Neri̇man İnanç
Turkish Journal of Medical Sciences
Background/aim: Clinical trials have shown that low glycemic index (GI) nutrition reduces mean blood glucose concentrations and insulin secretions. The aim of the present study was to determine the GI values of various monofloral (citrus, milk-vetch, chestnut, thyme, lime, pine) honeys of Turkey, and the effect of their consumption on glucose metabolism. Materials and methods: Processing data from 20 healthy volunteers, GI values were determined from the glycemia values by using the incremental area method. Serum insulin and C-peptide levels were also measured before and 120 min after the test. Results: The GI values of citrus, thyme, lime, chestnut, pine, …
Evaluation Of Maternal Serum Folate, Vitamin B12, And Homocysteine Levels Andfactor V Leiden, Factor Ii G.20210g>A, And Mthfr Variations In Prenatallydiagnosed Neural Tube Defects, Hati̇p Aydin, Resul Arisoy, Ali̇ Karaman, Emre Erdoğdu, Arda Çeti̇nkaya, Bi̇lgen Bi̇lge Geçki̇nli̇, Hasan Şi̇mşek, Oya Demi̇rci̇
Evaluation Of Maternal Serum Folate, Vitamin B12, And Homocysteine Levels Andfactor V Leiden, Factor Ii G.20210g>A, And Mthfr Variations In Prenatallydiagnosed Neural Tube Defects, Hati̇p Aydin, Resul Arisoy, Ali̇ Karaman, Emre Erdoğdu, Arda Çeti̇nkaya, Bi̇lgen Bi̇lge Geçki̇nli̇, Hasan Şi̇mşek, Oya Demi̇rci̇
Turkish Journal of Medical Sciences
Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a result of interactions between several genes and environmental factors. Many factors have been investigated in order to understand the etiology of NTDs, and many studies have identified folate intake as a common contributing factor. The exact etiology of the disease is still unknown. Materials and methods: In this study, we compared serum folate, vitamin B12, and homocysteine levels, along with common thrombophilia-related genetic variations, including factor V Leiden, factor II g.20210G>A, MTHFR c.677C>T, and MTHFR c.1298A>C, in 35 pregnant women with fetal NTDs and …
Nail Changes In Patients With Inflammatory Bowel Diseases, Özlem Eki̇z, Ebru Çeli̇k, İlknur Balta, Bi̇lge Bülbül Şen, Emi̇ne Nur Ri̇fai̇oğlu, Mehmet Demi̇r, Fuat Eki̇z, Ömer Başar, Osman Yüksel
Nail Changes In Patients With Inflammatory Bowel Diseases, Özlem Eki̇z, Ebru Çeli̇k, İlknur Balta, Bi̇lge Bülbül Şen, Emi̇ne Nur Ri̇fai̇oğlu, Mehmet Demi̇r, Fuat Eki̇z, Ömer Başar, Osman Yüksel
Turkish Journal of Medical Sciences
Background/aim: Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. To our knowledge, no studies to date pertain to the profile of nail changes in IBD, except for onychomycosis. We aimed to study the frequency and pattern of nail changes among patients with IBD and evaluate their potential relationships with several parameters in IBD. Materials and methods: The study included 73 patients with IBD and 51 healthy control subjects. Nails of both groups were examined for changes with regard to color, striations, texture, curvature of nail plates, dystrophy of nail plates, and pigmentation. …
Traditional Practices Of Konya Women During Pregnancy, Birth, The Postpartumperiod, And Newborn Care, Berri̇n Okka, Yasemi̇n Durduran, Nesli̇han Değerli̇ Kodaz
Traditional Practices Of Konya Women During Pregnancy, Birth, The Postpartumperiod, And Newborn Care, Berri̇n Okka, Yasemi̇n Durduran, Nesli̇han Değerli̇ Kodaz
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to identify traditional practices and the extent to which they are practiced by mothers during pregnancy, birth, the postpartum period, and newborn care. Materials and methods: This study was conducted in the city center of Konya (Turkey). Data were collected through questionnaires completed by volunteers. The research sample comprised 450 mothers, all of whom had given birth to at least one live baby. The forms were completed during face-to-face interviews. Results: Some traditional pregnancy practices were followed by 70.7% of the participants. Of the women who performed these practices, 57.4% consciously chose …
Free Radical-Induced Nephrotoxicity Following Repeated Oral Exposureto Chlorpyrifos Alone And In Conjunction With Fluoride In Rats, Naseer Baba, Rajinder Raina, Pawan Verma, Mudasir Sultana
Free Radical-Induced Nephrotoxicity Following Repeated Oral Exposureto Chlorpyrifos Alone And In Conjunction With Fluoride In Rats, Naseer Baba, Rajinder Raina, Pawan Verma, Mudasir Sultana
Turkish Journal of Medical Sciences
Background/aim: Chronic renal disorder is becoming a major health problem worldwide. The purpose of the present study was to investigate alterations in the renal antioxidant system in rats induced by repeated exposure to chlorpyrifos (CPF) alone and in conjunction with fluoride. Materials and methods: Wistar rats were randomly allocated to seven groups, each consisting of six rats, and were subjected to different treatment regiments for 28 days. Results: Significant increases (P < 0.05) in plasma protein, blood urea nitrogen, and creatinine levels indicated alterations in renal functions on repeated exposure to CPF or fluoride; moreover, these changes were more pronounced in animals exposed to both toxicants concurrently. A significant increase (P < 0.05) in malondialdehyde levels and decreases in superoxide dismutase, catalase, and glutathione peroxidase activities in renal tissue were noted, indicating renal damage on exposure to CPF, fluoride, or the combination of those. Conclusion: Our observations suggested that the concurrent exposure to CPF and fluoride increased the extent of renal damage. These findings indicate that this damage is due to increased free radical formation and a reduced function of the antioxidant system in renal tissue. Thus, the application of CPF as an insecticide should be reduced in areas where the fluoride levels in ground waters are high in order to minimize renal damage in exposed populations.
Combination Immunotherapy With Extract Of Heated 4t1 And Naloxone In Mouse Model Of Breast Cancer, Shervin Jahangiri, Seyyed Meysam Abtahi Froushani, Norouz Delirezh
Combination Immunotherapy With Extract Of Heated 4t1 And Naloxone In Mouse Model Of Breast Cancer, Shervin Jahangiri, Seyyed Meysam Abtahi Froushani, Norouz Delirezh
Turkish Journal of Medical Sciences
Background/aim: This study was designed to investigate the efficacy of a new vaccine against breast cancer, which was made by mixing the extract of heated 4T1 cells and naloxone, as an adjuvant. Materials and methods: Female BALB/c mice of 6-8 weeks old were challenged subcutaneously in the right flanks with 4T1 cells. When all animals developed a palpable tumor, immunotherapy was initiated. Mice in the experimental groups received, twice with a 1-week interval, either the extract of heated 4T1 alone or in combination with naloxone, and mice in the negative control group received phosphate-buffered saline. One week after the last …
Comparison Between The Protective Effects Of Vitamin K And Vitamin A On The Modulation Of Hypervitaminosis D3 Short-Term Toxicity In Adult Albino Rats, Said Said Elshama, Hosam-Eldin Hussein Osman, Ayman El-Meghawry El-Kenawy, Hamdi Mohamed Youseef
Comparison Between The Protective Effects Of Vitamin K And Vitamin A On The Modulation Of Hypervitaminosis D3 Short-Term Toxicity In Adult Albino Rats, Said Said Elshama, Hosam-Eldin Hussein Osman, Ayman El-Meghawry El-Kenawy, Hamdi Mohamed Youseef
Turkish Journal of Medical Sciences
Background/aim: Vitamin D3 has increased risk of toxicity due to its common use in multivitamin preparations. Vitamin K and vitamin A play an important role in vitamin D action. The goal of the current study was to compare the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 toxicity in rats by assessing serum calcium, renal function tests, cardiac enzymes, and related histopathological changes. Materials and methods: Eighty adult albino rats were divided into four groups; each group consisted of 20 rats. The first group received water; the second received a toxic dose of vitamin …
Evaluation Of The Effectiveness Of Biodegradable Electrospun Caprolactoneand Poly(Lactic Acid-?-Caprolactone) Nerve Conduits For Peripheral Nerveregenerations In A Rat Sciatic Nerve Defect Model, Mehmet Dadaci, Ni̇met Karagülle, Erhan Sönmez, Zeynep Dadaci, Evren Tevfi̇k İşci̇, Bi̇lsev İnce, İbrahi̇m Vargel, Erhan Pi̇şki̇n, Ali̇ Yücel Erk
Evaluation Of The Effectiveness Of Biodegradable Electrospun Caprolactoneand Poly(Lactic Acid-?-Caprolactone) Nerve Conduits For Peripheral Nerveregenerations In A Rat Sciatic Nerve Defect Model, Mehmet Dadaci, Ni̇met Karagülle, Erhan Sönmez, Zeynep Dadaci, Evren Tevfi̇k İşci̇, Bi̇lsev İnce, İbrahi̇m Vargel, Erhan Pi̇şki̇n, Ali̇ Yücel Erk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to compare electrospun caprolactone (EC) and poly(lactic acid-?-caprolactone) (PLCL) nerve conduits with nerve graft in a rat sciatic nerve defect model. Materials and methods: A total of 32 male Wistar albino rats were divided into 4 groups, with 8 rats in each group. A nerve defect of 1 cm was constructed in the left sciatic nerve of the rats. These defects were left denuded in the sham group, and reconstructed with nerve grafts, PLCL, and EC nerve conduits in the other groups. After 3 months, nerve regenerations were evaluated macroscopically, microscopically, and electrophysiologically. …
Ameliorating Effects Of Curcumin On Nicotine-Induced Mice Testes, Gülfi̇dan Coşkun, Hülya Özgür, Şaban Doran, Sai̇t Polat
Ameliorating Effects Of Curcumin On Nicotine-Induced Mice Testes, Gülfi̇dan Coşkun, Hülya Özgür, Şaban Doran, Sai̇t Polat
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the antioxidative effect of curcumin on nicotine-induced mice testis. Materials and methods: Sixty Swiss albino male mice were divided into five groups, each containing 12 mice. The first group was used as a control. To induce toxicity in the second and third group, nicotine (0.4 mg/kg/day) was injected intraperitoneally into mice for 14 and 28 days, respectively. The mice in the fourth and fifth group were injected with nicotine (0.4 mg/kg/day) and orally treated with curcumin (200 mg/kg) for 14 and 28 days, respectively. Testosterone levels were measured from blood samples …
The Protective Effect Of Capparis Ovata In Acute Hepatotoxicity Induced By Paracetamol, Nurcan Doğan, Mustafa Akçam, Tuğba Koca, Duygu Kumbul Doğuç, Meltem Özgöçmen
The Protective Effect Of Capparis Ovata In Acute Hepatotoxicity Induced By Paracetamol, Nurcan Doğan, Mustafa Akçam, Tuğba Koca, Duygu Kumbul Doğuç, Meltem Özgöçmen
Turkish Journal of Medical Sciences
Background/aim: To investigate the efficiency of Capparis ovata as a protective agent against acute paracetamol toxicity of the liver. Materials and methods: A total of 36 Wistar albino rats were divided into 4 groups: 1) paracetamol, 2) Capparis ovata + paracetamol, 3) Capparis ovata, and 4) control. Groups 2 and 3 were given Capparis ovata and Groups 1 and 4 distilled water for 8 days. On day 8, 3000 mg kg-1 paracetamol was administered orally to Groups 1 and 2. Samples were taken on day 9. AST, ALT, total bilirubin, direct bilirubin, GGT, and ALP levels were assessed. Lipid peroxidation …
Efficacy Of Pegylated Liposomal Etoposide Nanoparticles On Breast Cancer Cell Lines, Mohammadreza Mehrabi, Parisa Esmaeilpour, Azim Akbarzadeh, Zahra Saffari, Maryam Farahnak, Ali Farhangi, Mohsen Chiani
Efficacy Of Pegylated Liposomal Etoposide Nanoparticles On Breast Cancer Cell Lines, Mohammadreza Mehrabi, Parisa Esmaeilpour, Azim Akbarzadeh, Zahra Saffari, Maryam Farahnak, Ali Farhangi, Mohsen Chiani
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the efficacy of pegylated liposomal etoposide nanoparticles (NPs) against T-47D and MCF-7 breast cancer cell lines. Materials and methods: Pegylated liposomal etoposide NPs were prepared by reverse phase evaporation method. The size, size distribution, and zeta potential of the NPs was measured by a Zetasizer instrument. The cytotoxicity of NPs was inspected by methyl thiazol tetrazolium assay. The release pattern of the drug from the vesicles was studied by the dialysis method. Drug loading and encapsulation efficiency (EE) were also measured. Results: The mean size, size distribution, and zeta potential of pegylated liposomal etoposide …
Role Of Flt3 In The Proliferation And Aggressiveness Of Hepatocellular Carcinoma, Muammer Merve Aydin, Nermi̇n Sumru Bayin, Tolga Acun, Mustafa Cengi̇z Yakicier, Kami̇l Can Akçali
Role Of Flt3 In The Proliferation And Aggressiveness Of Hepatocellular Carcinoma, Muammer Merve Aydin, Nermi̇n Sumru Bayin, Tolga Acun, Mustafa Cengi̇z Yakicier, Kami̇l Can Akçali
Turkish Journal of Medical Sciences
Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models. Materials and methods: We used Snu398 cells that express FLT3. We investigated these cells' in vitro proliferation and invasion abilities by treatment with the FLT3 inhibitor K-252a or by knocking-down with FLT3 shRNA,. Furthermore, the effect of blocking FLT3 activity and …
Correlation Between Hfe Gene Polymorphisms And Increased Risk Of Coronary Artery Disease Among Patients With Type 2 Diabetes In Iran, Leila Saremi, Marzieh Saremi, Shirin Lotfipanah, Saber Imani, Junjiang Fu, Tianyu Zhang
Correlation Between Hfe Gene Polymorphisms And Increased Risk Of Coronary Artery Disease Among Patients With Type 2 Diabetes In Iran, Leila Saremi, Marzieh Saremi, Shirin Lotfipanah, Saber Imani, Junjiang Fu, Tianyu Zhang
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus is a risk factor for cardiovascular diseases (CVDs), which are among the major causes of deaths in type 2 diabetes (T2D). The purpose of the present study was to determine the association of C282Y and H63D mutations in the HFE gene with increased risk of coronary artery disease (CAD) in T2D patients. Materials and methods: Two hundred and ninety individuals were divided into two groups: a case group and a control group. Genomic DNA of peripheral venous blood cells was extracted and the HFE gene mutations were analyzed using the PCR-RFLP technique. Results: Data analysis revealed a …
The Utility Of The Timi Risk Index On Admission For Predicting Angiographic No-Reflow After Primary Percutaneous Coronary Intervention In Patients With Stemi, Hali̇t Acet, Faruk Ertaş, Mehmet Ata Akil, Mehmet Zi̇hni̇ Bi̇li̇k, Mesut Aydi̇n, Ni̇hat Polat, Abdulkadi̇r Yildiz, Murat Yüksel, Leyla Çi̇ftçi̇, Necdet Özaydoğdu, Mehmet Özbek, Sai̇t Alan, Ni̇zametti̇n Toprak
The Utility Of The Timi Risk Index On Admission For Predicting Angiographic No-Reflow After Primary Percutaneous Coronary Intervention In Patients With Stemi, Hali̇t Acet, Faruk Ertaş, Mehmet Ata Akil, Mehmet Zi̇hni̇ Bi̇li̇k, Mesut Aydi̇n, Ni̇hat Polat, Abdulkadi̇r Yildiz, Murat Yüksel, Leyla Çi̇ftçi̇, Necdet Özaydoğdu, Mehmet Özbek, Sai̇t Alan, Ni̇zametti̇n Toprak
Turkish Journal of Medical Sciences
Background/aim: The thrombolysis in myocardial infarction (TIMI) risk score (TRS), and the TIMI risk index (TRI) have been reported in coronary artery disease patients. We investigated whether admission TRI is associated with no-reflow (NRF) in patients undergoing primary percutaneous coronary intervention (p-PCI). Materials and methods: ST-segment elevation myocardial infarction (STEMI) patients treated with p-PCI were included in the study. TRI was calculated on admission using specified variables. We defined the angiographic NRF phenomenon as a coronary TIMI flow grade of ≤2 after the vessel was recanalized or a TIMI flow grade of 3 together with a final myocardial blush grade …
Seroprevalence Of Measles, Mumps, Rubella, And Varicella Amongphysicians And Nurses In Jordan, Faris Ghalib Bakri, Zakaria Mohammad Abdelrahim, Alqahira Samih Alkalbani, Ghada Mohammad Khrais, Deena Shamroukh, Ferial Ahmad Hayajneh, Azmi Mahafza
Seroprevalence Of Measles, Mumps, Rubella, And Varicella Amongphysicians And Nurses In Jordan, Faris Ghalib Bakri, Zakaria Mohammad Abdelrahim, Alqahira Samih Alkalbani, Ghada Mohammad Khrais, Deena Shamroukh, Ferial Ahmad Hayajneh, Azmi Mahafza
Turkish Journal of Medical Sciences
Background/aim: Measles, mumps, rubella, and varicella can affect susceptible healthcare workers who might subsequently spread the infection to susceptible patients and workers. Here, we aim to determine the seroprevalence of these infections among physicians and nurses and to compare the history of varicella with the results of varicella antibodies among study participants. Materials and methods: Two randomly selected groups, one group of physicians and one of nurses, from a university hospital in Jordan were interviewed and their serum IgG antibodies were measured. Results: The physicians and nurses group had 252 and 241 participants, respectively. The physicians group had significantly more …
Effectiveness Of P6 Acupoint Electrical Stimulation In Preventing Postoperativenausea And Vomiting Following Laparoscopic Surgery, Aik Hoe Yeoh, Shereen Suet Ping Tang, Norsidah Abdul Manap, Wan Rahiza Wan Mat, Shuraya Said, Muhamad Rahimi Che Hassan, Raha Abdul Rahman
Effectiveness Of P6 Acupoint Electrical Stimulation In Preventing Postoperativenausea And Vomiting Following Laparoscopic Surgery, Aik Hoe Yeoh, Shereen Suet Ping Tang, Norsidah Abdul Manap, Wan Rahiza Wan Mat, Shuraya Said, Muhamad Rahimi Che Hassan, Raha Abdul Rahman
Turkish Journal of Medical Sciences
Background/aim: The effects of pericardium 6 (P6) electrical stimulation in patients at risk of postoperative nausea and vomiting (PONV) following laparoscopic surgery were evaluated. Materials and methods: Eighty patients for laparoscopic surgery with at least one of the determined risks (nonsmoker, female, previous PONV/motion sickness, or postoperative opioid use) were randomized into either an active or sham group. At the end of surgery, Reletex electrical acustimulation was placed at the P6 acupoint. The active group had grade 3 strength and the sham group had inactivated electrodes covered by silicone. It was worn for 24 h following surgery. PONV scores were …