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Articles 1561 - 1590 of 4871
Full-Text Articles in Medicine and Health Sciences
Audiometric Threshold Shifts After Total Knee Arthroplasty By Using Gentamicin-Loaded Bone Cement, Adem Çöbden, İsmet Yalkin Çamurcu, Serap Bulut Çöbden, Hakan Sofu, Hani̇fi̇ Üçpunar, Ahmet Sevencan, Hüseyi̇n Demi̇rel
Audiometric Threshold Shifts After Total Knee Arthroplasty By Using Gentamicin-Loaded Bone Cement, Adem Çöbden, İsmet Yalkin Çamurcu, Serap Bulut Çöbden, Hakan Sofu, Hani̇fi̇ Üçpunar, Ahmet Sevencan, Hüseyi̇n Demi̇rel
Turkish Journal of Medical Sciences
Background/aim:The aim of this study was to investigate postoperative audiometric threshold shifts in patients who underwent primary total knee arthroplasty (TKA) using gentamicin-loaded bone cement (GLBC) in comparison with the ones who underwent TKA without GLBC.Materials and methods: Forty patients (gentamicin group) who underwent primary TKA usingGLBC and 29 patients (control group) who underwent primary TKA using standard bone cement were included in this prospective case-control study. Baseline pure-tone audiometric evaluation was performed preoperatively and repeated at the postoperative third day for all patients. Control audiometric evaluation was performed weekly for patients who were diagnosed with ototoxicity according to audiometric …
Is Body Mass Index A Risk Factor For Low Cerebral Oxygenation During Spinal Anesthesia In Women Undergoing Cesarean Section? A Preliminary Study, Gülçi̇n Aydin, Cemi̇le Dayangan Sayan
Is Body Mass Index A Risk Factor For Low Cerebral Oxygenation During Spinal Anesthesia In Women Undergoing Cesarean Section? A Preliminary Study, Gülçi̇n Aydin, Cemi̇le Dayangan Sayan
Turkish Journal of Medical Sciences
Background/aim: In this study, it was aimed to investigate the relationship between body mass index (BMI) and cerebral oxygenation during spinal anesthesia in women undergoing cesarean section. This study also aimed to demonstrate whether fetal cord blood oxygenation was affected by maternal BMI and/or delivery time.Materials and methods: The study included parturients with ASA I score undergoing cesarean section under spinal anesthesia in 2015 and 2016. They were divided into two groups according to BMI: Group 1 comprised parturients with BMI of
The Association Of Reduced Bone Density With Paraspinal Muscle Atrophy And Adipose Tissue In Geriatric Patients: A Cross-Sectional Ct Study, Eli̇f Evri̇m Eki̇n, Muhi̇tti̇n Emre Altunrende
The Association Of Reduced Bone Density With Paraspinal Muscle Atrophy And Adipose Tissue In Geriatric Patients: A Cross-Sectional Ct Study, Eli̇f Evri̇m Eki̇n, Muhi̇tti̇n Emre Altunrende
Turkish Journal of Medical Sciences
Background/aim: The aim of the study is to examine the relationship among bone density, adipose tissue, and muscle mass with abdominal CT in geriatric patients.Materials and methods: The study is a retrospective cohort study of patients 65 years and over who underwent abdominal CT for any reason between October 2017 and July 2018. Third lumbar vertebra density, fatty degeneration of the paraspinal muscle, subcutaneous adipose tissue, and mesenteric adipose tissue ratio were evaluated. Results: A total of 312 patients, 144 females and 168 males, were included in the study. Reduced bone density was found in 237 (76%) patients. Reduced bone …
Protective Effects Of Ghrelin On Kidney Tissue In Rats With Partial Ureteral Obstruction, Serhan Çi̇men, Cemal Taşdemi̇r, Ni̇gar Vardi, Burhan Ateş, Seda Taşdemi̇r, Ayla Özaydoğdu Çi̇men
Protective Effects Of Ghrelin On Kidney Tissue In Rats With Partial Ureteral Obstruction, Serhan Çi̇men, Cemal Taşdemi̇r, Ni̇gar Vardi, Burhan Ateş, Seda Taşdemi̇r, Ayla Özaydoğdu Çi̇men
Turkish Journal of Medical Sciences
Background/aim: The aim was to investigate the protective and therapeutic effects of ghrelin, which has antioxidant and antiinflammatory activity, on preventing kidney damage that occurs by induced partial ureteral obstruction in rats.Materials and methods: Twenty-eight adult male rats were included in the study, and the rats were divided into 4 groups. After the laparotomy operation on the sham group, the ureter was identified in the retroperitoneal area and was duly sutured (n = 7). Ghrelin was administered for seven days intraperitoneally, and after the nephrectomy performed on the 15th day, the rats were sacrificed (n = 7). A partial ureteral …
The Effectiveness Of Renal Nephrometry Score In Ablated Renal Tumors Via Radiofrequency Ablation Or Cryoablation, Seda Aladağ Kurt, Cem Yücel, Suna Özhan Oktar, Gonca Erbaş, Tevfi̇k Si̇nan Sözen, Ali̇ Yusuf Öner
The Effectiveness Of Renal Nephrometry Score In Ablated Renal Tumors Via Radiofrequency Ablation Or Cryoablation, Seda Aladağ Kurt, Cem Yücel, Suna Özhan Oktar, Gonca Erbaş, Tevfi̇k Si̇nan Sözen, Ali̇ Yusuf Öner
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the clinical efficacy of radiofrequency ablation (RFA) and cryotherapy and to scrutinize the therapeutic success of the RENAL (radius, exophytic/endophytic, nearness to collecting system, anterior/posterior, and location) nephrometry score in terms of possible complications and the predictive status of oncological results.Materials and methods: Forty-five patients with biopsy-proven renal cell carcinomas (32 males, 13 females) treated with RFA and cryotherapy were included. Patients were 22-90 years old (average: 59.2 years). Statistical analyses were performed using SPSS for Windows. Results: A total of 79 lesions with dimensions varying between 0.9 and 4.5 cm (average: 2.2 cm) …
Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin
Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin
Turkish Journal of Medical Sciences
Background/aim: Application fields of bone tissue engineering studies continue to expand. New biocompatible materials aimed to improve bone repairment and regeneration of implants are being discovered everyday by scientists, engineers, and surgeons. Our objective in this study is to combine polylactic acid which is a polymer with hydroxyapatite in the repairment of bone defects considering the increased need by medical application fields. Materials and methods: After 750 g of PLA with a diameter of 2.85 mm was granulated into minimum particles, these particles were homogenously mixed with hydroxyapatite prepared in laboratory environment. Using this mixture, HA-PLA filament with a diameter …
Is Leptin Receptor Expression Triggered In The Case Of Embryo Transfer To Endometrium Coculture?, İskender Kaplanoğlu, Gülnur Take Kaplanoğlu, Özgür Çinar, Güleser Göktaş, Serdar Di̇lbaz, Cemi̇le Merve Seymen
Is Leptin Receptor Expression Triggered In The Case Of Embryo Transfer To Endometrium Coculture?, İskender Kaplanoğlu, Gülnur Take Kaplanoğlu, Özgür Çinar, Güleser Göktaş, Serdar Di̇lbaz, Cemi̇le Merve Seymen
Turkish Journal of Medical Sciences
Background/aim: A synchronized dialogue between maternal and embryonic tissues is required for successful implantation. Low uterine receptivity is responsible for two-thirds of implantation failures and leptin is effective in the physiology of reproduction by binding to specific receptors. In this study, we investigateleptin receptor expression in cases of embryo transfer to endometrial coculture. Materials and methods: Biopsy materials were taken from 20 females with indication for coculture application and were cultured in an appropriate medium after the epithelial cells were isolated. The grown cells were cultured in chamber slides as the first group. For the second group, day 3 embryo …
Association Between Ppargc1a Single Nucleotide Polymorphisms And Increased Risk Of Nonalcoholic Fatty Liver Disease Among Iranian Patients With Type 2 Diabetes Mellitus, Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Zahra Hosseini-Khah, Behrooz Johari, Zohreh Saltanatpour
Association Between Ppargc1a Single Nucleotide Polymorphisms And Increased Risk Of Nonalcoholic Fatty Liver Disease Among Iranian Patients With Type 2 Diabetes Mellitus, Leila Saremi, Shirin Lotfipanah, Masumeh Mohammadi, Hassan Hosseinzadeh, Zahra Hosseini-Khah, Behrooz Johari, Zohreh Saltanatpour
Turkish Journal of Medical Sciences
Background/aim: Environmental and genetic factors may play a major role in the development of nonalcoholic fatty liver disease (NAFLD) among people with obesity and type 2 diabetes mellitus. Based on the fact that PGC-1?, as the protein encoded by the PPARGC1A gene, plays a key role in energy metabolism pathways, it has been hypothesized that polymorphisms within the PPARGC1Agene may be associated with increased risks of NAFLD. Thus, this study was designed to evaluate the Gly482Ser polymorphism (rs8192678) within the PPARGC1A gene and its association with the increased risk of NAFLD in Iranian patients with type 2 diabetes.Materials and methods: …
Comparison Of Intestinal Ischemia After On-Pump Versus Off-Pump Coronary Artery Bypass Grafting Surgery, Lütfi̇ Soylu, Oğuz Uğur Aydin, Mehmet Yildiz, Hacer Serdaroğlu, Murat Kurtoğlu, Sedat Karademi̇r
Comparison Of Intestinal Ischemia After On-Pump Versus Off-Pump Coronary Artery Bypass Grafting Surgery, Lütfi̇ Soylu, Oğuz Uğur Aydin, Mehmet Yildiz, Hacer Serdaroğlu, Murat Kurtoğlu, Sedat Karademi̇r
Turkish Journal of Medical Sciences
Acute mesenteric ischemia (AMI), one of the gastrointestinal system complications, which occurs following cardiac surgery, is challenged in the literature with a diminished incidence of AMI by heart surgery without cardiopulmonary bypass (CPB) or with pulsatile CPB. This study aims to compare the incidence and mortality rate of mesenteric ischemia in a series of consecutive patients undergoing coronary artery bypass grafting (CABG) through on-pump and off-pump techniques.Materials and methods: This study included patients who underwent CABG between 1 January 2010 and 31 June 2016. All patients were divided into two groups: Group 1 comprised 6396 CABG patients operated on with …
Colostrum Immunoglobulins And Oxidative Capacity May Be Affected By Infant Sex And Maternal Age And Parity, Davut Si̇nan Kaplan, Cahi̇t Bağci, Mustafa Örkmez, Özge Kömürcü Karuserci̇, Seyhun Sucu, Haki̇m Çeli̇k, Seyi̇than Taysi
Colostrum Immunoglobulins And Oxidative Capacity May Be Affected By Infant Sex And Maternal Age And Parity, Davut Si̇nan Kaplan, Cahi̇t Bağci, Mustafa Örkmez, Özge Kömürcü Karuserci̇, Seyhun Sucu, Haki̇m Çeli̇k, Seyi̇than Taysi
Turkish Journal of Medical Sciences
The aims of this study were to determine the levels of the total antioxidant status (TAS), the total oxidant status (TOS), the oxidative stress index (OSI), and the concentration of immunoglobulin A (IgA) and M (IgM) in colostrum, and evaluate relationships between these parameters and maternal age, maternal parity, and infant sex. Materials and methods: The analysis was performed in serum samples of colostrum which were collected from 90 mothers on the first day of lactation between 10:00 and 12:00 AM.Results: The measurements established that no significant association existed between the TAS level of colostrum and parity, maternal age, or …
8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng
8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng
Turkish Journal of Medical Sciences
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in many diseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Materials and methods: A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in the stable phase, and 110 AECOPD patients. Peripheral blood samples, demographic information, and clinical characteristics were collected from all subjects at the time of being recruited into the study. Plasma 8-OHdG level was detected by enzyme-linked immunosorbent assay.Results: 8-OHdG …
Serum Adropin Levels In Psoriasis Vulgaris And Its Relation With Metabolic Parameters, Selma Korkmaz, Gülben Sayilan Özgün
Serum Adropin Levels In Psoriasis Vulgaris And Its Relation With Metabolic Parameters, Selma Korkmaz, Gülben Sayilan Özgün
Turkish Journal of Medical Sciences
Adropin is a peptide-structure hormone that plays a role in preventing the development of insulin resistance, which has been linked to obesity and metabolic regulation. The purpose of this study is to assess serum adropin levels and their relationship with metabolic parameters in psoriasis vulgaris patients both with and without metabolic syndrome (MetS).Materials and methods: Fifty-three patients and 26 healthy controls were included in this study. Serum adropin levels, fasting blood glucose, fasting serum insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, and triglyceride levels of all participants were analyzed. Enzyme-linked immunosorbent assay was used to measure serum adropin …
Comparison Of Conventional And Modern Methods In Determining Ischemic Stroke Etiology By General And Stroke Neurologists, Refi̇k Kunt, Mustafa Kürşad Kutluk, Bedi̇le İrem Ti̇fti̇kci̇oğlu, Nazi̇re Efser Yeşi̇m Afşar Fak, Ali̇ Kemal Erdemoğlu, Muhteşem Gedi̇zli̇oğlu, Vesi̇le Öztürk
Comparison Of Conventional And Modern Methods In Determining Ischemic Stroke Etiology By General And Stroke Neurologists, Refi̇k Kunt, Mustafa Kürşad Kutluk, Bedi̇le İrem Ti̇fti̇kci̇oğlu, Nazi̇re Efser Yeşi̇m Afşar Fak, Ali̇ Kemal Erdemoğlu, Muhteşem Gedi̇zli̇oğlu, Vesi̇le Öztürk
Turkish Journal of Medical Sciences
This study aimed to investigate the consistency between stroke and general neurologists in subtype assignment using the Trial of ORG-10172 in Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems.Materials and methods: Fifty consecutive acute ischemic stroke patients admitted to the stroke unit were recruited. Patients were classified by two stroke and two general neurologists, each from different medical centers, according to TOAST followed by the CCS. Each neurologist was assessed for consistency and compliance in pairs. Concordance among all four neurologists was investigated and evaluated using the kappa (ĸ) value.Results: The kappa (ĸ) value of diagnostic compliance …
Role Of Iliac Crest Tangent In Correct Numbering Of Lumbosacral Transitional Vertebrae, Nesri̇n Gündüz, Gülci̇n Durukan Günaydin, Mehmet Bi̇lgi̇n Eser, Ahmet Aslan, Adnan Kabaali̇oğlu
Role Of Iliac Crest Tangent In Correct Numbering Of Lumbosacral Transitional Vertebrae, Nesri̇n Gündüz, Gülci̇n Durukan Günaydin, Mehmet Bi̇lgi̇n Eser, Ahmet Aslan, Adnan Kabaali̇oğlu
Turkish Journal of Medical Sciences
The iliac crest tangent (ICT) has recently emerged as a reliable landmark to correctly number the lumbosacral transitional vertebrae (LSTV). We retrospectively evaluated the reproducibility and accuracy of the ICT as a landmark in subjects without disc degeneration.Materials and methods: Fifty-eight patients with LSTV [19 female, 41 (26-52) years] and 55 controls without LSTV [23 female, 40 (26-55) years] who had undergone spinal computed tomography were included. The ICT was drawn on the coronal images, with the cursor in the sagittal view set to the posterior ⅓ of the vertebral body located one level above the LSTV. When more than …
Evaluation Of Myocardial Dispersion Of Repolarization In Patients With Heart Transplantation, Cengi̇z Burak, Erkan Baysal, Muhammed Süleymanoğlu, Çağri Yayla, Serkan Çay, Ümi̇t Kervan
Evaluation Of Myocardial Dispersion Of Repolarization In Patients With Heart Transplantation, Cengi̇z Burak, Erkan Baysal, Muhammed Süleymanoğlu, Çağri Yayla, Serkan Çay, Ümi̇t Kervan
Turkish Journal of Medical Sciences
The number of patients with heart transplantation has dramatically increased in the last decade. Considerable studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. We analyzed the dispersion of myocardial repolarization using electrocardiographic Tp-e interval and Tp-e/QTc ratio in patients with heart transplantation. Materials and methods: This observational study included 38 patients (12 female and 26 male) with heart transplantation and 38 well-matched controls. From electrocardiograms, Tp-e interval and Tp-e/QTc …
Branch Retinal Vein Occlusion Associated With Platelet Activation, Emrullah Beyazyildiz, Mehmet Çitirik, Mert Şi̇mşek, Özlem Beyazyildiz, İbrahi̇m Celaletti̇n Haznedaroğlu
Branch Retinal Vein Occlusion Associated With Platelet Activation, Emrullah Beyazyildiz, Mehmet Çitirik, Mert Şi̇mşek, Özlem Beyazyildiz, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to study subclinical platelet activation by detecting three important platelet activation parameters of mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in healthy control subjects.Materials and methods: This prospective study included 43 patients with BRVO (Group 1)and 40 control subjects (Group 2). The levels of MPV, PDW, and PCT were measured in both of the studied groups.Results: The mean serum level of MPV value was 7.64 ± 0.64 in Group 1 and 7.39 ± 0.42 in Group 2. …
Evaluation Of Measles Immunity In Turkey: Is It Still A Threat?, Selda Karaayvaz, Melahat Melek Oğuz, Ufuk Beyazova, Fatma Gülay Korukluoğlu, Yasemi̇n Coşgun, Zeli̇ha Güzelküçük, Fatma Nur Baran Aksakal, Fi̇gen Şahi̇n Dağli
Evaluation Of Measles Immunity In Turkey: Is It Still A Threat?, Selda Karaayvaz, Melahat Melek Oğuz, Ufuk Beyazova, Fatma Gülay Korukluoğlu, Yasemi̇n Coşgun, Zeli̇ha Güzelküçük, Fatma Nur Baran Aksakal, Fi̇gen Şahi̇n Dağli
Turkish Journal of Medical Sciences
Background/aim: Measles is one of the important vaccine-preventable diseases with many complications in childhood. This study presents cross-sectional seroepidemiological data, beginning from neonatal cord blood in infants to children under 6 years of age, about waning of measles antibody and tries to suggest the proper time for measles immunization.Materials and methods: A total of 564 blood samples consisting of neonatal cord blood and samples taken from infants and children at ages of 6, 9, 24-48, and 49-72 months were analyzed for measles seropositivity in a period of 6 months. Results: Measles seropositivity rate was 72.5% in 109 cord blood samples, …
Effects Of Ankaferd Hemostat On Red Blood Cell Aggregation: A Hemorheological Study, Rafi̇ye Çi̇ftçi̇ler, Sali̇h Aksu, Nesli̇han Hacer Di̇kmenoğlu Falkmarken, İbrahi̇m Celaletti̇n Haznedaroğlu
Effects Of Ankaferd Hemostat On Red Blood Cell Aggregation: A Hemorheological Study, Rafi̇ye Çi̇ftçi̇ler, Sali̇h Aksu, Nesli̇han Hacer Di̇kmenoğlu Falkmarken, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Background/aim:Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a prohemostatic agent affecting erythrocytes. The hemostatic action of ABS depends upon fibrinogen gamma chain, prothrombin, and red blood cells. The aim of this study was to assess the effects of ABS on erythrocyte aggregation via hemorheological analyses.Materials and methods: To measure erythrocyte aggregation, blood samples were obtained from healthy, nonsmoker volunteers who had not taken any medication in the previous 10 days. One mL of blood was placed into the laser-assisted optical rotational cell analyzer (LORCA), into the chamber formed by the gap between two concentric glass cylinders. The solution …
In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi
In Silico Design And In Vitro Development Of A Highly Accurate Test To Detect Brucella Species, Hosein Safari, Setareh Shahnazari, Maysam Mard-Soltani, Somayeh Tavakoli, Bahman Khalesi
Turkish Journal of Medical Sciences
Background: Conventionalmethods of detecting Brucella spp. suffer from technical and biological complications. Besides, newly characterized species of the genus Brucella could be neglected by previously designed polymerase chain reaction (PCR) tests. Therefore, a more accurate PCR-based test seems to be imminently needed. Materials and methods: Blood samples were collected from 39 patients diagnosed with brucellosis and 25 healthy controls. Multiple sequence alignments (MSA) were performed on 500 Omp2-related protein and gene sequences. Thereafter, specific primers were designed and synthesized for the regions with highest conservancy. The collected samples were assessed by PCR test. To overcome the cross-reactivity issue, PCR thermal …
Retracted Article: Prevalence And Antimicrobial Susceptibility Pattern Of Toxigenic Clostridium Difficilestrains Isolated In Iran, Maryam Mohammadbeigi, Zahra Safayi Delouyi, Nima Mohammadzadeh, Arash Ala'almohadesin, Keyvan Taheri, Elahe Edalati, Mansour Sedighi, Abed Zahedi Bialvaei
Retracted Article: Prevalence And Antimicrobial Susceptibility Pattern Of Toxigenic Clostridium Difficilestrains Isolated In Iran, Maryam Mohammadbeigi, Zahra Safayi Delouyi, Nima Mohammadzadeh, Arash Ala'almohadesin, Keyvan Taheri, Elahe Edalati, Mansour Sedighi, Abed Zahedi Bialvaei
Turkish Journal of Medical Sciences
No abstract provided.
Alterations In Serum Levels Of Copper, Zinc, And Selenium Among Children With Sickle Cell Anemia, Rana Hasanato
Alterations In Serum Levels Of Copper, Zinc, And Selenium Among Children With Sickle Cell Anemia, Rana Hasanato
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress contributes to pathophysiological dysfunction in sickle cell anemia (SCA). Copper (Cu) is a prooxidant, whereas zinc (Zn) and selenium (Se) are antioxidant trace elements. This study investigates the serum levels of Cu, Zn, and Se among children with SCA.Materials and methods: This cross-sectional study was performed at King Khalid University Hospital, Riyadh. Thirty-three children with SCA in steady state and 33 age- and sex-matched normal healthy children were included in the study. Cu, Zn, and Se levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) instrument.Results: The median serum Cu levels among SCA patients (1.3 -g/mL) were …
Hemophagocytic Lymphohistiocytosis: Epidemiological, Clinical And Biological Profile, Hanane Zahir, Jihane Belkhir, Hanane Mouhib, Mustapha Ait Ameur, Mohammed Chakour
Hemophagocytic Lymphohistiocytosis: Epidemiological, Clinical And Biological Profile, Hanane Zahir, Jihane Belkhir, Hanane Mouhib, Mustapha Ait Ameur, Mohammed Chakour
Turkish Journal of Medical Sciences
Background/aim: Hemophagocytic lymphohistiocytosis (HLH) is a clinical, biological, and pathological entity that is rare but has certain morbidity that may be life-threatening. This work aims to establish a focus on the hemophagocytic lymphohistiocytosis and analyze different aspects of diagnosis while emphasizing the biological data.Materials and methods: We report the results of a retrospective study conducted in the hematology department of Avicenna Hospital in Marrakesh. Thirty-one patients with hemophagocytic lymphohistiocytosis were enrolled.Results: The clinical presentation was dominated by fever and deterioration of the general state for almost all our patients. Splenomegaly was objectified in 90% of the patients. Hepatomegaly, lymphadenopathy, and …
Neutrophil To Lymphocyte Ratio As A Predictor Of Treatment Response And Mortality In Septic Shock Patients In The Intensive Care Unit, Rabi̇a Sari, Zühal Karakurt, Mustafa Ay, Muhammed Emi̇n Çeli̇k, Ülgen Yalaz Tekan, Fulya Çi̇yi̇ltepe, Feyza Kargin, Cüneyt Saltürk, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Nalan Adigüzel
Neutrophil To Lymphocyte Ratio As A Predictor Of Treatment Response And Mortality In Septic Shock Patients In The Intensive Care Unit, Rabi̇a Sari, Zühal Karakurt, Mustafa Ay, Muhammed Emi̇n Çeli̇k, Ülgen Yalaz Tekan, Fulya Çi̇yi̇ltepe, Feyza Kargin, Cüneyt Saltürk, Özlem Yazicioğlu Moçi̇n, Gökay Güngör, Nalan Adigüzel
Turkish Journal of Medical Sciences
Background/aim: While C-reactive protein (CRP) is a well-studied marker for predicting treatment response and mortality in sepsis, it was aimed to assess the efficacy of the neutrophil lymphocyte ratio (NLR) as a predictor of mortality and treatment response in sepsis patients in the intensive care unit (ICU). Materials and methods: In this retrospective cross-sectional study, sepsis patients were divided according to the presence of septic shock on the 1st day of ICU stay, and then subgrouped according to mortality. Patient demographics, acute physiologic and chronic health evaluation II and sequential organ failure assessment scores, NLR and CRP (on the 1st, …
Does Tumor Size Have Prognostic Value In Patients Undergoing Lymphadenectomy In Endometrioid-Type Endometrial Cancer Confined To The Uterine Corpus?, Caner Çakir, İsmet Çi̇ğdem Kiliç, Di̇lek Yüksel, Yalin Ay Karyal, Işin Üreyen, Gökhan Boyraz, Yasi̇n Durmuş, Murat Gülteki̇n, Nejat Özgül, Mustafa Alper Karalök, Mehmet Coşkun Salman, Kunter Yüce, Ahmet Taner Turan
Does Tumor Size Have Prognostic Value In Patients Undergoing Lymphadenectomy In Endometrioid-Type Endometrial Cancer Confined To The Uterine Corpus?, Caner Çakir, İsmet Çi̇ğdem Kiliç, Di̇lek Yüksel, Yalin Ay Karyal, Işin Üreyen, Gökhan Boyraz, Yasi̇n Durmuş, Murat Gülteki̇n, Nejat Özgül, Mustafa Alper Karalök, Mehmet Coşkun Salman, Kunter Yüce, Ahmet Taner Turan
Turkish Journal of Medical Sciences
Background/aim: We aimed to define the effect of tumor size on recurrence and survival rates in patients with stage I?II endometrioid-type endometrial cancer.Materials and methods: A total of 550 patients who had total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic-paraaortic lymphadenectomy were included. Patients with extrauterine spread, sarcomatous components, or synchronized tumor and those who did not undergo lymphadenectomy or did not have data on tumor size were excluded.Results: The median tumor size was 35 mm (range: 3?335 mm). According to the 2009 International Federation of Obstetrics and Gynecology (FIGO) criteria, 245 cases were defined as stage IA, 271 as stage …
Serum Prolidase Level In Patients With Brucellosis And Its Possible Relationship With Pathogenesis Of The Disease: A Prospective Observational Study, Oğuzhan Sitki Di̇zdar, Ayşe Turunç Özdemi̇r, Osman Başpinar, Derya Koçer, Yavuz Katircilar, İlhami̇ Çeli̇k
Serum Prolidase Level In Patients With Brucellosis And Its Possible Relationship With Pathogenesis Of The Disease: A Prospective Observational Study, Oğuzhan Sitki Di̇zdar, Ayşe Turunç Özdemi̇r, Osman Başpinar, Derya Koçer, Yavuz Katircilar, İlhami̇ Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Changes in collagen metabolism and fibroblastic activity may play a role in the pathogenesis of brucellosis. The prolidase enzyme plays an important role in collagen synthesis. We aimed to investigate the association of prolidase levels with brucellosis.Materials and methods: Serum prolidase levels in 20 patients newly diagnosed with brucellosis were compared with levels in 30 healthy control subjects. Patients with brucellosis were reassessed 3 months later for prolidase, other laboratory measurements, and response to treatment. Results: The levels of serum prolidase were significantly higher in brucellosis patients compared with those of healthy controls. Prolidase, sedimentation, and C-reactive protein levels …
Fabp4 Levels In Hypothyroidism And Its Relationship With Subclinical Atherosclerosis, Mürşi̇de Tan, Hakan Korkmaz, Hüseyi̇n Aydin, Duygu Kumbul Doğuç
Fabp4 Levels In Hypothyroidism And Its Relationship With Subclinical Atherosclerosis, Mürşi̇de Tan, Hakan Korkmaz, Hüseyi̇n Aydin, Duygu Kumbul Doğuç
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the relationship between serum fatty acid binding protein 4 (FABP4) levels and carotid intima media thickness (CIMT) in patients with hypothyroidism.Materials and methods: Forty subclinical hypothyroidism patients, 40 overt hypothyroidism patients, and 40 healthy controls were enrolled in the study. Blood pressure, body mass index, CIMT, fasting blood sugar, creatine, alanine aminotransferase, lipid parameters, insulin, free thyroxine, triiodothyronine, thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), high-sensitivity C-reactive protein (Hs-CRP), and FABP4 levels of all participants were measured.Results: Serum FABP4 levels were significantly higher in patients with subclinical and …
Ultrasound-Guided Pulsed Radiofrequency Neuromodulation Of The Suprascapular Nerve In Partial Rotator Cuff Tears, Ender Si̇r, Sami̇ Eksert
Ultrasound-Guided Pulsed Radiofrequency Neuromodulation Of The Suprascapular Nerve In Partial Rotator Cuff Tears, Ender Si̇r, Sami̇ Eksert
Turkish Journal of Medical Sciences
Background/Aim: Pulsed radiofrequency (PRF) of the suprascapular nerve has been shown to be effective in the treatment of chronic shoulder pain. Ultrasound (US) guidance has gained popularity in regional blocks recently. This study aims to investigate the efficacy of suprascapular nerve pulsed radiofrequency under the guidance of ultrasonography. Materials and methods: This retrospective study included patients treated with PRF of the suprascapular nerve with a diagnosis of partial rotator cuff tears. The patients were assessed with a numeric rating scale (NRS), the Shoulder Pain and Disability Index (SPADI), and a Likert patient satisfaction score before the treatment and 3 weeks …
Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar
Effects Of Phenytoin Injection On Vocal Cord Healing After Mechanical Trauma: An Experimental Study, Si̇bel Ali̇cura Tokgöz, Cem Saka, İstemi̇han Akin, Fatma Fulya Köybaşioğlu, Saffet Kiliçaslan, Murat Çalişkan, Ömer Beşalti, Emel Çadalli Tatar
Turkish Journal of Medical Sciences
Background/aim: Phenytoin is an anticonvulsant drug which causes fibroblast proliferation, collagen synthesis, and an increase in epidermal growth factor. Therefore, the aim of the present study is to evaluate the effect of phenytoin injection on the wound healing process in rats with vocal cord injury by histopathological methods. Materials and methods: The vocal cords of 10 albino Wistar rats were damaged bilaterally; the left vocal cord was kept as the control group. Phenytoin was injected in the right vocal cord. Ten rats were sacrificed. The thickness of the lamina propria and density of the fibroblast and collagen were evaluated histopathologically.Results: …
An Old Friend: Uric Acid And Its Association With Fractional Flow Reserve, Sali̇h Topal, Burak Sezenöz, Mustafa Candemi̇r, Eser Açikgöz, Sadik Kadri̇ Açikgöz, Nuri̇ Bülent Boyaci
An Old Friend: Uric Acid And Its Association With Fractional Flow Reserve, Sali̇h Topal, Burak Sezenöz, Mustafa Candemi̇r, Eser Açikgöz, Sadik Kadri̇ Açikgöz, Nuri̇ Bülent Boyaci
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography.Materials and methods: We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of 0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer.Results: The …
Evaluation Of Medial Olivocochlear Efferent System And Hearing Loss In Patients With Primary Sjögren's Syndrome, Bülent Gündüz, Nuri̇ye Yildirim, Serdar Can Güven, Emre Orhan, Recep Karamert, Zafer Günendi̇
Evaluation Of Medial Olivocochlear Efferent System And Hearing Loss In Patients With Primary Sjögren's Syndrome, Bülent Gündüz, Nuri̇ye Yildirim, Serdar Can Güven, Emre Orhan, Recep Karamert, Zafer Günendi̇
Turkish Journal of Medical Sciences
Background/aim: Autoimmune diseases are a remarkable issue for researchers due to their adverse effects on the auditory system, but for primary Sjögren's syndrome (pSS) there is little research on the comprehensive audiological findings in literature. The main objective of this study was to investigate the medial olivocochlear efferent functions of subjects with pSS and to examine the audiological findings.Materials and methods: The study included 36 subjects with pSS and 36 healthy subjects. All the subjects underwent testing including pure tone, speech, and high frequency audiometry; tympanometry and acoustic reflexes; distortion product otoacoustic emissions (DPOAE); and suppression of DPOAE.Results: The hearing …