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Articles 1531 - 1560 of 4871
Full-Text Articles in Medicine and Health Sciences
The Negative Effects Of Dry Eye Disease On Quality Of Life And Visual Function, Lee W. Guo, Esen Akpek
The Negative Effects Of Dry Eye Disease On Quality Of Life And Visual Function, Lee W. Guo, Esen Akpek
Turkish Journal of Medical Sciences
In recent years, dry eye has become a hot topic within ophthalmology and optometry, especially in regards to new frontiers in treatment modalities which include novel devices, procedures, and medications. However, some of the more understudied areas in dry eye involve its impact on quality of life. Although ocular discomfort symptoms are well known to be associated with dry eye, its negative effects on visual function remain underrecognized. This paper reviews these topics within the currently published literature to heighten awareness among clinicians.
Thalamocortical Network Interruption: A Fresh View For Migraine Symptoms, Hayrunni̇sa Bolay Belen
Thalamocortical Network Interruption: A Fresh View For Migraine Symptoms, Hayrunni̇sa Bolay Belen
Turkish Journal of Medical Sciences
Migraine is a multifaceted brain disorder where multisensory disturbances are associated with headache. Yet sensory symptoms are conventionally justified by dysfunctions confined to the cerebral cortex, a perspective through the complex interplay of thalamocortical network would provide the entire picture, more pertinent to the central sensory processing. It is important to consider thalamus as a hub that integrates multiple domains via extensive connections among anatomically and functionally separate cortical areas. Accordingly, cortical spreading depression (CSD), implicated in migraine pathophysiology can be seen as a tool to disconnect thalamocortical network by functionally eliminating cerebral cortex. Hence, including thalamic reticular nucleus and …
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Turkish Journal of Medical Sciences
A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and …
Adjustable Bone Plate: State Of Art, Gazi̇ Huri̇
Adjustable Bone Plate: State Of Art, Gazi̇ Huri̇
Turkish Journal of Medical Sciences
Background/aim: The success of treatment of bone fracture and defects are based on a proper contact and compression between the bone fracture fragments. Intraoperative manipulations such as bone compression or distractions are generally done in order to achieve this. However, none of the bone plates currently in routine use allow these manipulations after fixation to the bone, requiring refixation and repeated drilling, and screwing operations. Based on this shortcoming, we designed a novel adjustable bone plate (ABP) system which allows bone shortening and lengthening even after fixation to the bone surface. The aim of the paper is to clarify the …
Update On Liver Transplantation-Newer Aspects, Rahşan Olga Meti̇n, Cem Şi̇mşek, Ahmet Ömür Gürakar
Update On Liver Transplantation-Newer Aspects, Rahşan Olga Meti̇n, Cem Şi̇mşek, Ahmet Ömür Gürakar
Turkish Journal of Medical Sciences
Liver transplantation (LT) remains the only therapeutic option offering gold standard treatment for end-stage liver disease (ESLD) and acute liver failure (ALF), as well as for certain early-stage liver tumors. Currently, the greatest challenge facing LT is the simple fact that there are not enough adequate livers for all the potential patients that could benefit from LT. Despite efforts to expand the donor pool to include living and deceased donors, organ shortage is still a major problem in many countries. To solve this problem, the use of marginal liver grafts has become an inevitable choice. Although the definition of marginal …
Molecular Subtyping Bladder Cancer: Is It Ready For Clinical Practice?, Funda Vakar Lopez
Molecular Subtyping Bladder Cancer: Is It Ready For Clinical Practice?, Funda Vakar Lopez
Turkish Journal of Medical Sciences
Bladder cancer, one of the more common cancers, is a heterogeneous disease, both morphologically and clinically. Although histological classification and extent of the disease (staging) guide treatment options, the heterogeneity in responses to therapy highlights the need for better stratification of patients for the appropriate therapy in order to achieve better outcomes. Several molecular classifications of muscle-invasive bladder cancer have been proposed but currently their use in clinical practice is limited by the complexity of the methods used and diversity of the subtypes.
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Turkish Journal of Medical Sciences
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in several organs. With the advent of genetic and molecular techniques, mutations in the TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with neurologic symptoms comprising a significant source of morbidity and mortality. In 2012, the diagnostic criteria for TSC were revised by …
Igg4-Related Disease: A Contemporary Review, Hazan Karadeni̇z, Augusto Vaglio
Igg4-Related Disease: A Contemporary Review, Hazan Karadeni̇z, Augusto Vaglio
Turkish Journal of Medical Sciences
Background/aim: Immunoglobulin G4-related disease (IgG4-RD), is an immune-mediated fibroinflammatory condition, which may involve multiple organs and mostly presents with high serum IgG4 levels and specific histopathological characteristics. As IgG4-RD is a relatively new entity the etiology, prevalence and epidemiologic knowledge is quite limited. Although involvement of almost all anatomical regions has been reported, the most commonly affected regions are pancreas, lacrimal glands, salivary glands, retroperitoneum, orbita, lymph nodes, kidney and lungs. Diagnosis is made with combined evaluation of clinical, radiological and histopathological findings. Typical histopathological features include storiform fibrosis, dense lymphoplasmacytic infiltrates and obliterative phlebitis. Its course is typically marked …
Graft-Versus-Cancereffect And Innovative Approaches In Thetreatment Of Refractorysolid Tumors, Uğur Şahi̇n, Taner Demi̇rer
Graft-Versus-Cancereffect And Innovative Approaches In Thetreatment Of Refractorysolid Tumors, Uğur Şahi̇n, Taner Demi̇rer
Turkish Journal of Medical Sciences
Background/aim: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been used for the treatment of various refractory solid tumors during the last two decades. After the demonstration of graft-versus-leukemia (GvL) effect in a leukemic murine model following allo-HSCT from other strains of mice, graft-versus-tumor (GvT) effect in a solid tumor after allo-HSCT has also been reported in a murine model in 1984. Several trials have reported the presence of a GvT effect in patients with various refractory solid tumors, including renal, ovarian and colon cancers, as well as soft tissue sarcomas [1]. The growing data on haploidentical transplants also indicate GvT …
Ankaferd Hemostat: From Molecules To Medicine, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu
Ankaferd Hemostat: From Molecules To Medicine, Rafi̇ye Çi̇ftçi̇ler, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Ankaferd hemostat (ABS; Ankaferd Blood Stopper® , İstanbul, Turkey) is a hemostatic agent having an impact on red blood cell-fibrinogen interactions. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The entire physiological process involves ABS-induced formation of the protein network by vital erythrocyte aggregation. Vital erythrocyte aggregation occurs with the spectrine, ankyrin, and actin proteins on the membrane of the red blood cells. ABS notably affects cell metabolism and cell cycle mechanisms. Meanwhile, ABS has antiproliferative effects on cancer cells. The aim of this review …
Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan
Thiol-Disulfide Homeostasis: An Integrated Approach With Biochemical And Clinical Aspects, Özcan Erel, Serpi̇l Erdoğan
Turkish Journal of Medical Sciences
Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition …
Data-Driven Identification Of Chemopreventive Agents For Breast Cancer, Deni̇z Can Güven, Cemal Orhan, Kazi̇m Şahi̇n, Fatih Mehmet Uçkun
Data-Driven Identification Of Chemopreventive Agents For Breast Cancer, Deni̇z Can Güven, Cemal Orhan, Kazi̇m Şahi̇n, Fatih Mehmet Uçkun
Turkish Journal of Medical Sciences
Preclinical animal models of breast cancer provide the opportunity to identify chemopreventive drugs with single-agent activity as well as effective multi-modality regimens for primary as well as secondary prevention in high-risk persons. Our group has used the 7,12-dimethylbenz(a)anthracene (DMBA) mouse model of carcinogen-induced breast cancer to explore the clinical potential of two tyrosine kinase inhibitors and a nucleoside analog as chemopreventive agents. All three agents exhibited promising preclinical activity both as monotherapy and as components of combination therapy with the standard chemotherapy drug paclitaxel. The tumors developing despite chemoprevention were not only small and grew slowly, but they also displayed …
Results Of Genicular Nerve Ablation By Radiofrequency In Osteoarthritis-Related Chronic Refractory Knee Pain, Zafer Yasi̇n Konya, Suna Akin Takmaz, Hülya Başar, Bülent Baltaci, Gülçi̇n Babaoğlu
Results Of Genicular Nerve Ablation By Radiofrequency In Osteoarthritis-Related Chronic Refractory Knee Pain, Zafer Yasi̇n Konya, Suna Akin Takmaz, Hülya Başar, Bülent Baltaci, Gülçi̇n Babaoğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the medium- to long-term effects of radiofrequency (RF) ablation of genicular nerves for chronic refractory knee pain due to osteoarthritis (OA).Materials and methods: Forty-eight patients who underwent RF ablation of the genicular nerves were evaluated retrospectively. The visual analogue scale (VAS) score, Western Ontario and McMaster universities osteoarthritis index (WOMAC index), opioid and nonsteroidal antiinflammatory drug (NSAID) use score, quality of life score, and treatment satisfaction score were examined at 1, 3, and 6 months after the procedure.Results: The mean VAS scores were significantly lower at the 1-, 3-, and 6-month …
The Efficacy Of The 3-Dimensional Vibe-Caipirinha-Dixon Technique In The Evaluation Of Pancreatic Steatosis, Ural Koç, Gökhan Ocakoğlu, Oktay Algin
The Efficacy Of The 3-Dimensional Vibe-Caipirinha-Dixon Technique In The Evaluation Of Pancreatic Steatosis, Ural Koç, Gökhan Ocakoğlu, Oktay Algin
Turkish Journal of Medical Sciences
Background/aim: CAIPIRINHA is a new technique in abdominal imaging. Pancreatic steatosis (PS) is a subject of increasing scientific interest. The aim of this study was to investigate the efficacy of the isotropic 3D-VIBE- CAIPIRINHA -DIXON technique on a new generation 3-tesla MR unit in the evaluation of PS.Materials and methods: In this retrospective study, the imaging findings of 49 patients with PS and 41 control subjects were examined. The pancreas-to-spleen ratio (PSR), pancreas-to-muscle ratio (PMR), and pancreatic signal intensity index (PSII) were defined as 3 new parameters and these indexes were calculated from the in-phase/out of phase 3D-VIBE- CAIPIRINHA-DIXON images. …
Effects Of Oral/Enteral Nutrition Alone Versus Plus Pantoprazole On Gastrointestinalbleeding In Critically Ill Patients With Low Risk Factor: A Multicenter, Randomizedcontrolled Trial, Kürşat Gündoğan, Emre Karakoc, Turgut Teke, Avşar Zerman, Ali̇ye Esmaoglu, Şahi̇n Temel, Muhammet Güven, Murat Sungur
Effects Of Oral/Enteral Nutrition Alone Versus Plus Pantoprazole On Gastrointestinalbleeding In Critically Ill Patients With Low Risk Factor: A Multicenter, Randomizedcontrolled Trial, Kürşat Gündoğan, Emre Karakoc, Turgut Teke, Avşar Zerman, Ali̇ye Esmaoglu, Şahi̇n Temel, Muhammet Güven, Murat Sungur
Turkish Journal of Medical Sciences
Background/aim: Critically ill patients are at risk of developing gastrointestinal (GI) bleeding due to stress causing mucosal damage. Aim of the study was to determine the effect of oral/enteral nutrition with or without concomitant pantoprazole on upper GI bleeding in low risk critically ill patients. Materials and methods: This was a prospective, randomized, open-label, multicenter study conducted with intensive care unit (ICU) patients receiving oral/enteral nutritional support. Patients were randomly assigned into two groups including intervention group (received oral/EN plus pantoprazole) and control group (received only oral/EN). Results: A total of 300 patients (intervention group: 152, control group: 148) participated …
Comparison The Accuracy And Trending Ability Of Cardiac Index Measured By The Fourth- Generation Of Flotrac With The Picco Device In Septic Shock Patients, Bodin Khwannimit, Rattina Jomsuriya
Comparison The Accuracy And Trending Ability Of Cardiac Index Measured By The Fourth- Generation Of Flotrac With The Picco Device In Septic Shock Patients, Bodin Khwannimit, Rattina Jomsuriya
Turkish Journal of Medical Sciences
Background/aim: FloTrac/Vigileo is a noncalibrated arterial pressure waveform analysis for cardiac index (CI) monitoring. The aim of our study was to compare the CI measured by the 4th generation of FloTrac with PiCCO in septic shock patients. Materials and methods: We simultaneously measured the CI using FloTrac (CIv) and compared it with the CI derived from transpulmonary thermodilution (CItd) as well as the pulse contour-derived CI using PiCCO (CIp). Results: Thirty-one septic shock patients were included. The CIv correlated with CItd (r = 0.62, P < 0.0001). The Bland-Altman analysis showed a bias of 0.14, and the limits of agreement were ?1.62?1.91 L/min/m2 with a percentage error of 47.4%. However, the concordance rate between CIv and CItd was 93.6%. The comparison of CIv with CIp (n = 352 paired measurements) revealed a bias of -0.16, and the limits of agreement were ?1.45?1.79 L/min/m2 with a percentage error of 44.8%. The overall correlation coefficient between CIv and CIp was 0.63 (P < 0.0001), and the concordance rate was 85.4%. Conclusion: The 4th generation of FloTrac has not acceptable agreement to assess CI; however, it has the ability to tracked changes of CI, when compared with the transpulmonary thermodilution method by PiCCO.
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Turkish Journal of Medical Sciences
Background/aim: A scale for behavioural pain assessment is useful for the detection and determination of pain in the elderly with dementia. This study aimed to translate and evaluate the psychometric properties of Doloplus-2 in the elderly with dementia in Iran. Materials and methods: In this methodological study, after translation and evaluating the face and content validity of Doloplus-2, 100 elderly people were selected by the convenience sampling method in Kashan, 2018-2019. Exploratory factor analysis, convergent validity, and known-groups comparison were applied to determine construct validity. Reliability was also assessed through internal consistency, equivalence, and stability methods were used. The ceiling …
Posterior Fossa Horns; A New Calvarial Finding Of Mucopolysaccharidoses With Well-Known Cranial Mri Features, Çağri Damar, Betül Emi̇ne Deri̇nkuyu, Muazzez Asburçe Bi̇ke Olgaç Kiliçkaya, Mehmet Öztürk, Çi̇ğdem Öztunali, Ayşe Gül Alimli, Öznur Leman Boyunaga, Murat Uçar, Fati̇h Süheyl Ezgü, Leyla Tümer, Alp Özgün Börcek, Ahmet Siğirci
Posterior Fossa Horns; A New Calvarial Finding Of Mucopolysaccharidoses With Well-Known Cranial Mri Features, Çağri Damar, Betül Emi̇ne Deri̇nkuyu, Muazzez Asburçe Bi̇ke Olgaç Kiliçkaya, Mehmet Öztürk, Çi̇ğdem Öztunali, Ayşe Gül Alimli, Öznur Leman Boyunaga, Murat Uçar, Fati̇h Süheyl Ezgü, Leyla Tümer, Alp Özgün Börcek, Ahmet Siğirci
Turkish Journal of Medical Sciences
Background/aim: Mucopolysaccharidoses (MPS) are a group of hereditary metabolic diseases. The aim of this study was to share the previously unreported calvarial finding of internal hypertrophy of the occipitomastoid sutures (IHOMS) together with some other well- known cranial MRI findings in this patient series. Materials and methods: A retrospective evaluation was conducted of 80 cranial MRIs of patients who had been diagnosed and followed up with MPS from 2008 to 2019 in our center. Of these patients, 11 had Hurler, 14 had Hunter, 24 had Sanfilippo, 15 had Morquio, 14 had Maroteaux-Lamy, and 2 had Sly disease. The cranial MRIs …
Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan
Comparison Of The Efficacy Between Bilateral Proximal Tubal Occlusion And Total Salpingectomy On Ovarian Reserve And The Cholinergic System: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu, Cengi̇z Şanli, Şeyda Yavuzkir, Zehra Sema Özkan
Turkish Journal of Medical Sciences
Background and aim: To compare the effects of bilateral proximal tubal occlusion and bilateral total salpingectomy on ovarian reserve and the cholinergic system via rat experiment. Materials and methods: Twenty-one adult female rats were randomly divided into the following three groups: G1 (n = 7), sham group; G2 (n = 7), bilateral total salpingectomy group; and G3 (n = 7), bilateral proximal tubal occlusion group. Four weeks later, the abdomen of the rats was opened. The right ovarian tissues were stored in 10% formaldehyde, whereas the left ovarian tissues were stored at ?80 °C in aluminum foil. Serum samples were …
The Effect Of Baicalein On Wnt/Ss-Catenin Pathway And Mir-25 Expression In Saos-2 Osteosarcoma Cell Line, Esra Örenli̇li̇ Yaylagül, Celal Ülger
The Effect Of Baicalein On Wnt/Ss-Catenin Pathway And Mir-25 Expression In Saos-2 Osteosarcoma Cell Line, Esra Örenli̇li̇ Yaylagül, Celal Ülger
Turkish Journal of Medical Sciences
Background/aim: Osteosarcoma is the most common primary bone malignancy that occurs frequently in children and adolescents. Baicalein, a flavonoid that has attracted great attention in recent years with its strong antitumor activity, shows a wide range of biological and pharmaceutical effects.MicroRNAs have been found to be involved in many critical processes in cancers. This study aimed to investigate the effect of baicalein and miR-25 on Wnt/ß-catenin signaling pathway of osteosarcoma cell line Saos-2. Materials and methods: Cell viability was assessed, and qRT-PCR and Western blot were performed to study the effects of baicalein on expression of Wnt/ß-catenin signaling pathway-realted genes …
Alcohol Consumption And Alcohol Policy, Mustafa Necmi̇ İlhan, Di̇lek Yapar
Alcohol Consumption And Alcohol Policy, Mustafa Necmi̇ İlhan, Di̇lek Yapar
Turkish Journal of Medical Sciences
Alcohol is a unique addictive substance used by many people for different reasons. Alcohol use affects not only the users but also the family and the whole society in a negative way. Alcohol is one of the most commonly used substances for entertainment purposes in the world and 1 in 3 people is a current drinker. 2348 billion people (43% of the population) aged 15 and over are current drinkers and males drink about 2 times more frequently than females (53.6%/32.3%). According to the Global Alcohol and Health Report published by the World Health Organization (WHO) (2018), total alcohol per …
Validity And Reliability Study Of The Turkish Version Of The Self-Efficacy For Managing Chronic Disease 6-Item Scale, Kübra İnci̇rkuş, Nursen Nahci̇van
Validity And Reliability Study Of The Turkish Version Of The Self-Efficacy For Managing Chronic Disease 6-Item Scale, Kübra İnci̇rkuş, Nursen Nahci̇van
Turkish Journal of Medical Sciences
Background/aim: The measurement of self-efficacy is an important step toward improving chronic disease management, enhancing adherence to treatment, and assessing patients with chronic diseases. The purpose of this study was to assess the validity and reliability of the Turkish version of theSelf-Efficacy for Managing Chronic Disease 6-Item Scale. Materials and methods: In this methodological study, the sample consisted of 211 patients receiving chronic disease care in 2 family health centers in İstanbul, Turkey. Data were analyzed with descriptive statistics, exploratory and confirmatory factor analyses, concurrent validity, Cronbach's alpha, item-total correlation, and test-retest reliability.Results: Most of the sample were women (72%), …
Treatment Of Idiopathic Granulomatous Mastitis And Factors Related With Disease Recurrence, Emre Tekgöz, Seda Çolak, Muhammet Çinar, Sedat Yilmaz
Treatment Of Idiopathic Granulomatous Mastitis And Factors Related With Disease Recurrence, Emre Tekgöz, Seda Çolak, Muhammet Çinar, Sedat Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Idiopathic granulomatous mastitis is a rare, benign inflammatory disease of breast. There is no general agreement on the appropriate treatment choice.The aim of the study was to investigate the immunosuppressive administer for idiopathic granulomatous mastitis and risk factors related with disease recurrence.Materials and methods: The data of 53 patients with idiopathic granulomatous mastitis were evaluated for this cross-sectional retrospective study. Demographic features and clinical characteristics and course of the patients were obtained from file records. Results: The mean age of the patients was 37.2 ± 6.6 years. Fifty-one of 53 patients received immunosuppressive treatment with or without surgery. Forty-seven …
Omics Era In Forensic Medicine: Towards A New Age, Ramazan Akçan, Burak Taşteki̇n, Mahmut Şeri̇f Yildirim, Hali̇t Canberk Aydogan, Necdet Sağlam
Omics Era In Forensic Medicine: Towards A New Age, Ramazan Akçan, Burak Taşteki̇n, Mahmut Şeri̇f Yildirim, Hali̇t Canberk Aydogan, Necdet Sağlam
Turkish Journal of Medical Sciences
Background/aim: Forensic medicine and sciences is a multidisciplinary branch of science, which frequently benefit from novel technologies. State of the art omics technologies have begun to be performed in forensic medicine and sciences, particularly in postmortem interval, intoxication, drugs of abuse, diagnosis of diseases and cause of death. This review aims to discuss the role and use of great omics (metabolomics, proteomics, genomics and transcriptomics) in forensic sciences, in detail. Materials and methods: A detailed review of related literature was performed, and studies were subdivided as per the type of omics.Results and conclusion: Omics seems as a revolutionary step in …
Diagnostic Approach In Parenchymal Lung Diseases: Transbronchial Lung Biopsy Or Cryobiopsy?, Ali̇ Kadri̇ Çirak, Nuran Katgi, Onur Fevzi̇ Erer, Pinar Çi̇men, Fatma Fevzi̇ye Tuksavul, Burçi̇n Hakoğlu
Diagnostic Approach In Parenchymal Lung Diseases: Transbronchial Lung Biopsy Or Cryobiopsy?, Ali̇ Kadri̇ Çirak, Nuran Katgi, Onur Fevzi̇ Erer, Pinar Çi̇men, Fatma Fevzi̇ye Tuksavul, Burçi̇n Hakoğlu
Turkish Journal of Medical Sciences
Background/aim: Diagnosis of interstitial lung diseases requires a multidisciplinary approach, and a gold standard for histological diagnosis is open lung biopsy. Transbronchial lung biopsy (TBLB) and in recent years an alternative method, cryobiopsy (TBLC), are used for the diagnosis of parenchymal lung lesions. The aim of this study is to compare the efficacy of concomitant conventional TBLB and TBLC. Materials and methods: A total of 82 patients who underwent TBLC for diagnosis of diffuse parenchymal lung diseases at Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital between 2015 and 2018 were screened retrospectively and included in the …
The Importance Of Quality And Accreditation In Health Care Services In The Process Ofstruggle Against Covid-19, Demet Gökmen Kavak, Ayşe Si̇bel Öksüz, Canan Cengi̇z, İbrahi̇m Hali̇l Kayral, Fi̇gen Çi̇zmeci̇ Şenel
The Importance Of Quality And Accreditation In Health Care Services In The Process Ofstruggle Against Covid-19, Demet Gökmen Kavak, Ayşe Si̇bel Öksüz, Canan Cengi̇z, İbrahi̇m Hali̇l Kayral, Fi̇gen Çi̇zmeci̇ Şenel
Turkish Journal of Medical Sciences
Background/aim: The aim of this research is to evaluate the relationship between the quality of health and accreditation standards with the Covid-19 process and to reveal the importance of quality and accreditation in health care in the process of combating coronavirus. Materials and methods: The relationship between hospital accreditation standards of Turkish Healthcare Quality and Accreditation Institute and the Covid-19 process was evaluated. The standards were analyzed within the framework of the technical guidance areas provided by the World Health Organization for countries for the Covid-19 process. Results: The standards were found to be 79,6% related to the Covid-19 process. …
The Effects Of Hand Splinting In Patients With Early-Stage Thumb Carpometacarpaljoint Osteoarthritis: A Randomized, Controlled Study, Asli Can, Ni̇hal Tezel
The Effects Of Hand Splinting In Patients With Early-Stage Thumb Carpometacarpaljoint Osteoarthritis: A Randomized, Controlled Study, Asli Can, Ni̇hal Tezel
Turkish Journal of Medical Sciences
Background/aim: Evidence for the effectiveness of splinting in thumb carpometacarpal osteoarthritis is limited. We aimed to evaluate the effects of a prefabricated carpometacarpal metacarpophalangeal immobilization splint on pain, hand function, and hand strength in patients with early-stage thumb carpometacarpal osteoarthritis. Materials and methods: Sixty-three hands with stage 1 or 2 thumb carpometacarpal osteoarthritis were enrolled in the study. The nonsplint group received oral information about how to accommodate daily activities. The splint group was given a prefabricated carpometacarpal metacarpophalangeal immobilization splint for 6 weeks. Pain was evaluated using the Australian/Canadian Osteoarthritis Hand Index (AUSCAN). Hand functions were evaluated using the …
Tetanus Vaccine During Pregnancy: Data Of A Tertiary Hospital In Turkey, Gülşah Dağdevi̇ren, Gökçen Örgül, Aykan Yücel, Di̇lek Şahi̇n
Tetanus Vaccine During Pregnancy: Data Of A Tertiary Hospital In Turkey, Gülşah Dağdevi̇ren, Gökçen Örgül, Aykan Yücel, Di̇lek Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: To evaluate the prevalence of tetanus vaccination in pregnant women and determine the factors affecting the vaccination and barriers to vaccination. Materials and methods: An observational-descriptive study was conducted on 494 women who gave birth at the Etlik Zübeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey. Participants were divided into 2 groups, vaccinated and unvaccinated. Sociodemographic characteristics, obstetric history, and prenatal care status were compared between the 2 groups. Results: There were 242 (48.9%) and 252 (51.1%) women in the vaccinated and unvaccinated groups, respectively. The vaccination rate decreased as the number of pregnancies increased (P = …
A Novel Turkish Instrument For Assessing Quality Of Life In Chronic Otitis Media -Translation And Validation Of Zurich Chronic Middle Ear Inventory, Belgi̇n Tutar, Zi̇ya Saltürk, Güler Berki̇ten, Muhammet Eni̇s Eki̇nci̇oğlu, Semi̇h Karaketi̇r, Meli̇s Ece Arkan, Muhammed Fati̇h Akgün, Ayça Başkadem Yilmazer, Ercan Kulak, Davi̇d Baechi̇nger, Yavuz Uyar
A Novel Turkish Instrument For Assessing Quality Of Life In Chronic Otitis Media -Translation And Validation Of Zurich Chronic Middle Ear Inventory, Belgi̇n Tutar, Zi̇ya Saltürk, Güler Berki̇ten, Muhammet Eni̇s Eki̇nci̇oğlu, Semi̇h Karaketi̇r, Meli̇s Ece Arkan, Muhammed Fati̇h Akgün, Ayça Başkadem Yilmazer, Ercan Kulak, Davi̇d Baechi̇nger, Yavuz Uyar
Turkish Journal of Medical Sciences
Background/aim: The Zurich Chronic Middle Ear Questionnaire (ZCMEI-21) is a newly-developed German-language questionnaire. The purpose of this study was to analyze the quality of life (QoL) of chronic otitis media (COM) patients and translate, transculturally adapt, and validate the ZCMEI-21 into Turkish. Materials and methods: Based on internationally accepted guidelines, the ZCMEI-21 was translated into Turkish. To assess its validity, the total score of the ZCMEI-21-Tur was compared to the scores taken from the original validation study and a question that was directly related to the health-related QoL (HRQoL), as well as the general criterion EQ-5D-5L. Questionnaires were completed by …
Down-Regulation Of Circular Rnaitch And Circhipk3 In Gastric Cancer Tissues, Sara Ghasemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour
Down-Regulation Of Circular Rnaitch And Circhipk3 In Gastric Cancer Tissues, Sara Ghasemi, Modjtaba Emadi-Baygi, Parvaneh Nikpour
Turkish Journal of Medical Sciences
Background/aim: Gastric cancer (GC) is one of the major causes of cancer mortality worldwide. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5' and 3' ends. They are very stable and abundant in eukaryotes. As there were no reported studies on the expression profiles of circular RNA ITCH (cir-ITCH) and circHIPK3 in GC, in the current study, we aimed to delineate the expression profiles and clinicopathological relevance of these two circRNAs in GC tissues compared to their paired adjacent noncancerous tissues.Materials and methods: Quantitative real-time polymerase chain reaction was performed …