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Articles 1081 - 1110 of 4871
Full-Text Articles in Medicine and Health Sciences
Factors Influencing The Length Of Stay In The Palliative Care Unit In Patients Dischargedhome: Results From A Tertiary Hospital In Turkey, Hi̇lal Zengi̇n, İlker Taşçi
Factors Influencing The Length Of Stay In The Palliative Care Unit In Patients Dischargedhome: Results From A Tertiary Hospital In Turkey, Hi̇lal Zengi̇n, İlker Taşçi
Turkish Journal of Medical Sciences
Background/aim: Increased length of stay (LOS) in the palliative care unit (PCU) is a serious burden to the patients and the health care system. The predictors of longer LOS in a PCU have not been reported so far from Turkey. Our aim in this study was to evaluate the factors associated with the LOS in the PCU of a tertiary hospital. Materials and methods: This cross-sectional analysis of a retrospective cohort evaluated adult patients' medical records admitted to the PCU between 2017 and 2019. The main inclusion criteria were 4 or more days of palliative unit stay and being discharged …
The Utility Of Magnetic Resonance Angiography In Children With Nutcracker Syndrome, Di̇lara Atasoy, Ayşegül Cansu, Ayşe Füsun Beki̇rçavuşoğlu, Eli̇f Bahat Özdoğan, Ali̇ Ahmetoğlu
The Utility Of Magnetic Resonance Angiography In Children With Nutcracker Syndrome, Di̇lara Atasoy, Ayşegül Cansu, Ayşe Füsun Beki̇rçavuşoğlu, Eli̇f Bahat Özdoğan, Ali̇ Ahmetoğlu
Turkish Journal of Medical Sciences
Background/aim: The presented study aimed to evaluate the utility of magnetic resonance angiography (MRA) in the pediatric population with nutcracker syndrome. Materials and methods: Patients with suggestive clinical symptoms and laboratory findings and got the diagnosis of nutcracker syndrome with Doppler ultrasonography between January 2011-2019 were included in the study. In addition, children who had renal MRA due to hypertension were evaluated as the control group. MRA images of all patients were examined retrospectively by three radiologists at different levels of experience, and the superior mesenteric artery angle, aorta-mesenteric distance, left renal vein diameter both in the regions of aorta-mesenteric, …
Assessment Of Fragmented Qrs Formation And Its Relationship With Left Ventricularhypertrophy In Nonhypertensive Acromegaly Patients, Muhammet Dural, Göknur Yorulmaz, Eli̇f Sevi̇l Alagüney, Kadi̇r Uğur Mert, Ezgi̇ Çamli, Ahmet Toygar Kalkan, Aysen Akalin, Medi̇ne Nur Kebapçi, Ahmet Serdar Yilmaz, Selda Murat, Fatma Belgi̇n Efe
Assessment Of Fragmented Qrs Formation And Its Relationship With Left Ventricularhypertrophy In Nonhypertensive Acromegaly Patients, Muhammet Dural, Göknur Yorulmaz, Eli̇f Sevi̇l Alagüney, Kadi̇r Uğur Mert, Ezgi̇ Çamli, Ahmet Toygar Kalkan, Aysen Akalin, Medi̇ne Nur Kebapçi, Ahmet Serdar Yilmaz, Selda Murat, Fatma Belgi̇n Efe
Turkish Journal of Medical Sciences
Background/aim: It is known that the presence of fragmented QRS (fQRS) on electrocardiography (ECG) is associated with cardiovascular events. The aim of this study was the evaluation of fQRS formation and its relationship with the left ventricular hypertrophy (LVH) parameters in acromegaly patients. Materials and methods: In total, 47 previously diagnosed with non-hypertensive acromegaly patients and 48 control subjects were included in the study. ECG and transthoracic echocardiography (TTE) were performed for each participant. Acromegaly patients were divided into two groups according to the fQRS formation on the ECG. Left ventricular wall thicknesses, and left atrial diameter (LAD), left ventricular …
Quantitative Analysis Of Distal Femoral Epiphysis Blood Supply In Healthy Infants Withsuperb Microvascular Imaging: A Pilot Study, Emi̇ne Çalişkan, Muhammed Samed Cansiz, Hati̇ce Ariöz Habi̇bi̇, Mehmet Öztürk
Quantitative Analysis Of Distal Femoral Epiphysis Blood Supply In Healthy Infants Withsuperb Microvascular Imaging: A Pilot Study, Emi̇ne Çalişkan, Muhammed Samed Cansiz, Hati̇ce Ariöz Habi̇bi̇, Mehmet Öztürk
Turkish Journal of Medical Sciences
Background/aim: This study aimed to determine the blood supply of the distal femoral epiphysis (DFE) using superb microvascular imaging in newborns and infants, and to investigate the correlation with ossification center (OC) length, sex, and age. Materials and methods: A total of 140 cases were evaluated in this study. The cases were divided into 2 groups of less than 90 days and over 90 days. Cartilage blood supply was measured with vascularity index (%) (VI). Results: The mean OC length and median VI values were measured as 10.20 ± 3.72 mm and 0.80% (0.58-1.50) for boys and 10.03 ± 3.36 …
1,25-Dihydroxyvitamin D3 Regulates T Helper And B Lymphocyte Responsessubstantially In Drug-Naive Primary Sjögren's Syndrome Patients' Mononuclear Cells, Deni̇z Genç, Merve Sezer Kürkçü, Burcu Günaydin, Emi̇ne Fi̇gen Tarhan
1,25-Dihydroxyvitamin D3 Regulates T Helper And B Lymphocyte Responsessubstantially In Drug-Naive Primary Sjögren's Syndrome Patients' Mononuclear Cells, Deni̇z Genç, Merve Sezer Kürkçü, Burcu Günaydin, Emi̇ne Fi̇gen Tarhan
Turkish Journal of Medical Sciences
Background/aim: A correlation between vitamin D deficiency and primary Sjögren's syndrome (pSS) has already been described. The limited data has been reported regarding the pathological relevance of vitamin D in primary Sjögren's syndrome. In this study, the peripheral blood mononuclear cells were cocultured with 1,25-dihydroxyvitamin D3 to determine the modulatory effect of vitamin D3 on T and B lymphocyte phenotypes in pSS. Materials and methods: Venous blood samples were collected from 11 patients in the treatment phase and 9 drug-naive pSS patients. Peripheral blood mononuclear cells (PBMC) were isolated and separately cultured in the presence and absence of 1,25- dihydroxyvitamin …
Can Omentin-1 Be A Prognostic Marker In Surgical Intensive Care Patients?, Yücel Gülteki̇n, İsmai̇l Bi̇ri̇, Afi̇g Gojayev, Selen Yilmaz Işikhan, Oytun Portakal Akçi̇n, Yusuf Alper Kiliç
Can Omentin-1 Be A Prognostic Marker In Surgical Intensive Care Patients?, Yücel Gülteki̇n, İsmai̇l Bi̇ri̇, Afi̇g Gojayev, Selen Yilmaz Işikhan, Oytun Portakal Akçi̇n, Yusuf Alper Kiliç
Turkish Journal of Medical Sciences
Background/aim: A member of the adipokine family, omentin-1 is selectively secreted from visceral fat tissue and the omentum. It has been shown that omentin-1 is involved in the pathogenesis of certain diseases and can be used as a prognostic marker. This study first investigated the prognostic significance of omentin-1 in surgical intensive care patients. In addition, the relationship between omentin-1 and laboratory and clinical parameters commonly used in intensive care units (ICUs) was evaluated. Materials and methods: One hundred and fifty-four patients hospitalized in the surgical ICU were included in the study. Blood samples for omentin-1 were collected from the …
What Plays A Role In The Severity Of Atopic Dermatitis In Children?, Murat Cansever, Çi̇ğdem Oruç
What Plays A Role In The Severity Of Atopic Dermatitis In Children?, Murat Cansever, Çi̇ğdem Oruç
Turkish Journal of Medical Sciences
Background/aim: Determining the characteristics and risk factors of severe disease is extremely important to combat atopic dermatitis (AD), which has recently shown increasing prevalence. In this study, we aimed to investigate the clinical characteristics of pediatric patients with AD and identifying the factors associated with the severity of the disease. Materials and methods: A total of 304 pediatric patients diagnosed with atopic dermatitis were included in the study. The patients' age at admission, age at onset of symptoms, the presence of atopy history in their family, eosinophil levels obtained from blood counts were recorded, together with the data of cigarette …
The Contribution Of Neurocognitive Situation, Physical Capacity And Daily Life Activities Toquality Of Life In Childhood Acute Lymphoblastic Leukemia Survivors, Eli̇f Keleş Gülnerman, Yağmur Çam, Bülent Elbasan, Şebnem Soysal, Zühre Kaya, İdi̇l Yeni̇cesu, Ülker Koçak
The Contribution Of Neurocognitive Situation, Physical Capacity And Daily Life Activities Toquality Of Life In Childhood Acute Lymphoblastic Leukemia Survivors, Eli̇f Keleş Gülnerman, Yağmur Çam, Bülent Elbasan, Şebnem Soysal, Zühre Kaya, İdi̇l Yeni̇cesu, Ülker Koçak
Turkish Journal of Medical Sciences
Background/aim: There are no extensive studies on the QL in children who completed acute lymphoblastic leukemia (ALL) treatment and currently living without any disease in Turkey. Our study aimed to analyze both the QL and the effects of physical, neurocognitive capacities on QL in childhood ALL survivors aged 7-12 years at the time of recruitment. Materials and methods: PedsQL cancer module 3.0 child and proxy report, for ages 5-7 and 8-12 years, WeeFIM scale, BOTMP Short Form, RPM, reading, writing, and mathematics assessment tools, sociodemographic information form were carried out to the children and their family. Results: There was no …
The Effects Of Vitamin D Supplemantation On Prognosis In Patients With Mildobstructive Sleep Apnea Syndrome, Feri̇de Ayyildiz, Hi̇lal Yildiran, Nigar Afandiyeva, Özlem Gülbahar, Oğuz Köktürk
The Effects Of Vitamin D Supplemantation On Prognosis In Patients With Mildobstructive Sleep Apnea Syndrome, Feri̇de Ayyildiz, Hi̇lal Yildiran, Nigar Afandiyeva, Özlem Gülbahar, Oğuz Köktürk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effect of vitamin D on the disease prognosis and biochemical parameters in patients with mild obstructive sleep apnea syndrome (OSAS). Materials and methods: Nineteen adult male individuals (18-65 years) who were diagnosed with mild OSAS after polysomnography and had low vitamin D levels were included in the study. Each week, patients took 50.000 IU Vitamin D3 supplementation for 8 weeks. Polysomnography, biochemical parameters FBG (fasting blood glucose), lipid profile (TG, TC, LDL-C, HDL-C, VLDL-C), calcium, phosphorus, parathormone, calcitonin, serum 25(OH)D, insulin, CRP, TNF-α, IL-6, and IL-10 of patients were evaluated …
Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman
Allergic Bronchopulmonary Aspergillosis In Children, Özge Atay, Suna Asi̇lsoy, Gi̇zem Atakul, Serdar Al, Özge Kangalli Boyacioğlu, Nevi̇n Uzuner, Özkan Karaman
Turkish Journal of Medical Sciences
Background/aim: Allergic bronchopulmonary aspergillus (ABPA) is a lung disease caused by hypersensitivity from Aspergillus fumigatus. Diagnostic criteria, staging systems and treatment methods for ABPA disease have been reported in studies evaluating populations, the majority of which are adult patients. Our study aimed to discuss the use of ABPA diagnostic criteria in children, the success of other alternative regimens to oral corticosteroids in the treatment of ABPA, and the changes that occur during treatment, in the light of the literature. Materials and methods: Between January 2017 and 2020, patients diagnosed with ABPA at the Dokuz Eylül University Child Allergy and Immunology …
Fatty Acid-Binding Protein-4 As A Biomarker Predicting Acromegaly-Associated Diabetesmellitus, Sema Hepşen, Pinar Akhanli, Hakan Düğer, Murat Çalapkulu, Beki̇r Uçan, Muhammed Erkam Sencar, Davut Sakiz, İlknur Öztürk Ünsal, Seyi̇t Murat Bayram, Mustafa Özbek, Erman Çakal
Fatty Acid-Binding Protein-4 As A Biomarker Predicting Acromegaly-Associated Diabetesmellitus, Sema Hepşen, Pinar Akhanli, Hakan Düğer, Murat Çalapkulu, Beki̇r Uçan, Muhammed Erkam Sencar, Davut Sakiz, İlknur Öztürk Ünsal, Seyi̇t Murat Bayram, Mustafa Özbek, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: The known pathogenesis of diabetes mellitus (DM) in acromegaly is mainly based on growth hormone (GH) and insulin-like growth factor-1 (IGF-1) excess. Fatty acid-binding protein 4 (FABP-4), a novel adipokine, is found to induce insulin resistance and type 2 DM. We aimed to investigate the possible effect of FABP-4 on glucose metabolism in patients with acromegaly. Materials and methods: This case-control study included 28 patients newly diagnosed with acromegaly and 57 healthy volunteers. The patients with acromegaly were classified according to their glycemic status as with DM, prediabetes, and normal glucose tolerance. Anthropometric measurements, laboratory test results, and FABP-4 …
A Nationwide Retrospective Study In Turkish Children With Nephrocalcinosis, Serra Sürmeli̇ Döven, Sebahat Tülpar, Funda Baştuğ, Zeynep Nagehan Yürük Yildirim, Esra Karabağ Yilmaz, Nesli̇han Çi̇çek, Nuran Küçük, Eli̇f Çomak, Burcu Yazicioğlu, Hülya Nalçacioğlu, Ali̇ Deli̇baş, Berfi̇n Uysal, Ayşe Ağbaş, Ati̇lla Gemi̇ci̇, Nesli̇han Günay
A Nationwide Retrospective Study In Turkish Children With Nephrocalcinosis, Serra Sürmeli̇ Döven, Sebahat Tülpar, Funda Baştuğ, Zeynep Nagehan Yürük Yildirim, Esra Karabağ Yilmaz, Nesli̇han Çi̇çek, Nuran Küçük, Eli̇f Çomak, Burcu Yazicioğlu, Hülya Nalçacioğlu, Ali̇ Deli̇baş, Berfi̇n Uysal, Ayşe Ağbaş, Ati̇lla Gemi̇ci̇, Nesli̇han Günay
Turkish Journal of Medical Sciences
Background/aim: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. Materials and methods: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010-2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. Results: …
Serum Antiganglioside Antibodies In Patients With Autoimmune Limbic Encephalitis, Ayla Çulha Oktar, Özlem Selçuk, Cansu Tunç, Şenol Işildak, Eli̇f Şanli, Vuslat Yilmaz, Bi̇rgül Baştan Tüzün, Murat Kürtüncü, Ayşe Özlem Çokar, Erdem Tüzün
Serum Antiganglioside Antibodies In Patients With Autoimmune Limbic Encephalitis, Ayla Çulha Oktar, Özlem Selçuk, Cansu Tunç, Şenol Işildak, Eli̇f Şanli, Vuslat Yilmaz, Bi̇rgül Baştan Tüzün, Murat Kürtüncü, Ayşe Özlem Çokar, Erdem Tüzün
Turkish Journal of Medical Sciences
Background/aim: Ganglioside antibodies are identified not only in patients with inflammatory neuropathies but also several central nervous system disorders and paraneoplastic neuropathies. Our aim was to investigate whether ganglioside antibodies are found in autoimmune encephalitis patients and may function as a diagnostic and prognostic biomarker. Materials and methods: Sera and cerebrospinal fluid (CSF) samples of 33 patients fulfilling the criteria for probable autoimmune encephalitis were collected within the first week of clinical manifestation. None of the patients had evident symptoms and findings of peripheral polyneuropathy. Well-characterized antineuronal and paraneoplastic antibodies were investigated in sera and CSF and antiganglioside (antiGM1, GM2, …
Mefv Mutation Frequencies In A Turkish Cohort With Low Prevalence Of Familialmediterranean Fever, Necati̇ Çakir, Hülya Azakli, Duran Üstek, Ömer Uysal, Eren Gözke
Mefv Mutation Frequencies In A Turkish Cohort With Low Prevalence Of Familialmediterranean Fever, Necati̇ Çakir, Hülya Azakli, Duran Üstek, Ömer Uysal, Eren Gözke
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF) is a genetically recessive autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene. The aim of this study was to investigate the frequencies of the most common MEFV mutations among a sample of healthy individuals from the Havsa population of European Turkey, where FMF is less prevalent compared to Asian Turkey. Materials and methods: The study group consisted of 263 unrelated healthy adults. All of the participants were analyzed for the M694V, V726A, M680I, and E148Q mutations in the MEFV gene. Results: In total, 25 of the 263 individuals carried MEFV mutations (9.5%). …
Country-Based Report: The Safety Of Omalizumab Treatment In Pregnant Patients Withasthma, Bi̇lun Gemi̇ci̇oğlu, Arzu Di̇dem Yalçin, Yavuz Havlucu, Gül Karakaya, Levent Özdemi̇r, Meti̇n Keren, Sevi̇m Bavbek, Dane Edi̇ger, İpek Kivilcim Oğuzülgen, Zeynep Ferhan Özşeker, Ayşe Arzu Yorgancioğlu
Country-Based Report: The Safety Of Omalizumab Treatment In Pregnant Patients Withasthma, Bi̇lun Gemi̇ci̇oğlu, Arzu Di̇dem Yalçin, Yavuz Havlucu, Gül Karakaya, Levent Özdemi̇r, Meti̇n Keren, Sevi̇m Bavbek, Dane Edi̇ger, İpek Kivilcim Oğuzülgen, Zeynep Ferhan Özşeker, Ayşe Arzu Yorgancioğlu
Turkish Journal of Medical Sciences
Background/aim: We aimed to report outcomes of pregnant patients with asthma under omalizumab treatment and their infants in our country. Materials and methods: Patients with asthma who received omalizumab for at least 6 months and at least one dose during their pregnancy were retrospectively evaluated using a questionnaire regarding their disease and therapy and the health of their infants. Results: Twenty pregnant patients and their 23 infant's data were analyzed. The mean delivery age was 31.8 ± 7.4 years. They received omalizumab for 28.9 ± 21.8 months. Eight (36.4%) patients showed exacerbation of the disease during pregnancy. Forced expiratory volume …
Prediction Of Posttraumatic Stress Disorder By Acute Stress Disorder In Traffic Accidentsurvivors, Xiuli Li, Luyi Sun, Qiang Li, Li Wang
Prediction Of Posttraumatic Stress Disorder By Acute Stress Disorder In Traffic Accidentsurvivors, Xiuli Li, Luyi Sun, Qiang Li, Li Wang
Turkish Journal of Medical Sciences
Background/aim: To investigate the predictive effect of different symptoms of early acute stress disorder (ASD) on posttraumatic stress disorder (PTSD) in traffic accident survivors. Materials and methods: A total of 206 traffic accident survivors were assessed with the acute stress disorder scale (ASDS) within 2-23 days after accidents, as well as with 17-item PTSD checklist-specific stressor version (PCL-S) during 4?12 months after accidents. All into the first group of subjects by senior surgeon assessment, based on the clinical, radiological and laboratory examination, excluded traumatic brain injuries, and mild brain injury. And then, assessment by clinical psychological practitioner. Results: The severity …
Nondamaging Retinal Laser Therapy In Recurrent Diabetic Macular Edema After Antivegf Injections, Mehmet Çitirik
Nondamaging Retinal Laser Therapy In Recurrent Diabetic Macular Edema After Antivegf Injections, Mehmet Çitirik
Turkish Journal of Medical Sciences
Background/aim: Subthreshold yellow nondamaging retinal laser therapy (NRT) could provide a greater safety profile when compared to conventional laser methods. NRT may also improve diabetic macular edema (DME). This study aims to assess whether the severity of DME affects the efficacy of subthreshold yellow NRT. Materials and methods: The study included 70 eyes that had previously been treated with ranibizumab for DME and then developed recurrent macular edema, which was treated with NRT once. The central foveal thickness (CFT) and best-corrected visual acuity (BCVA) were evaluated retrospectively 2 months following the NRT. The eyes in the study were divided into …
Diagnostic Value Of Procalcitonin And C Reactive Protein For Infection And Sepsis Inelderly Patients, Çi̇ler Zi̇nci̇rci̇oğlu, Kazim Rollas, Işil Güldoğan, Aykut Saritaş, Hüseyi̇n Özkarakaş, Gürsel Ersan, Ni̇met Şenoğlu
Diagnostic Value Of Procalcitonin And C Reactive Protein For Infection And Sepsis Inelderly Patients, Çi̇ler Zi̇nci̇rci̇oğlu, Kazim Rollas, Işil Güldoğan, Aykut Saritaş, Hüseyi̇n Özkarakaş, Gürsel Ersan, Ni̇met Şenoğlu
Turkish Journal of Medical Sciences
Background/aim: Biomarkers are useful for diagnosing infection and sepsis in adults, but data are limited in elderly patients. Furthermore, clinical symptoms of infection in elderly patients are usually atypical or unclear. We aimed to assess the usefulness of PCT, CRP, and WBC in distinguishing elderly patients infected with sepsis from infected without sepsis and those with no-infection. We also aimed to find a cut-off value for diagnosing sepsis and infection without sepsis in elderly critically ill patients. Materials and methods: In this single-center and prospective observational study, patients older than 65 years were enrolled. Serum levels of PCT, CRP, and …
Incidence, Risk Factors, And Adverse Outcomes Of Acute Kidney Injury In Very Prematureneonates: A Single Center Experience, Nuran Üstün
Turkish Journal of Medical Sciences
Background/aim: Acute kidney injury (AKI) is a serious morbidity in premature neonates. The aim of this study was to determine the incidence of AKI and to evaluate its impact on morbidity and mortality in very premature infants. Materials and methods: This retrospective cohort study was conducted in the neonatal intensive care unit (NICU). A total of 410 preterm infants who were born before 32 gestational weeks were screened and 318 were included in this analysis. AKI was defined according to the modified neonatal Kidney Disease: Improving Global Outcomes criteria. Results: The incidence of AKI was 32.1% (102/318). Regression analyses revealed …
Risk Of Autism Spectrum Disorder In Children With A History Of Hospitalization Forneonatal Jaundice, Gaffari̇ Tunç, Ayla Uzun Çi̇çek, Fati̇h Kiliçbay
Risk Of Autism Spectrum Disorder In Children With A History Of Hospitalization Forneonatal Jaundice, Gaffari̇ Tunç, Ayla Uzun Çi̇çek, Fati̇h Kiliçbay
Turkish Journal of Medical Sciences
Background/aim: Limited research has focused explicitly on the association between neonatal jaundice and autism spectrum disorder (ASD), and inconclusive evidence exists in the literature within this framework. This study aimed specifically to investigate whether neonatal jaundice is a potential risk factor for ASD and whether there is a connection between the types of neonatal jaundice and the severity of ASD. Materials and method: This study involved 119 children with ASD [90 males (75.6%), 29 females (24.4%), mean age: 45.39 ± 11.29 months] and 133 healthy controls [100 males (75.2%), 33 females (24.8%), mean age: 46.92 ± 11.42 months]. Psychiatric disorders …
Relationship Between C-Reactive Protein To Albumin Ratio And Coronary Artery Calciumscore And Cad-Rads Scores With Coronary Computed Tomography Angiography, Mehmet Aki̇f Erdöl, Kadri̇ye Gayretli̇ Yayla
Relationship Between C-Reactive Protein To Albumin Ratio And Coronary Artery Calciumscore And Cad-Rads Scores With Coronary Computed Tomography Angiography, Mehmet Aki̇f Erdöl, Kadri̇ye Gayretli̇ Yayla
Turkish Journal of Medical Sciences
Background/aim: C-reactive protein (CRP) to albumin ratio (CAR) is predictive marker of systemic inflammatory state in atherosclerotic coronary diseases when compared to predictive value of these two markers separately. We aimed to evaluate the relationship between CAR and the coronary artery calcium (CAC) score, Coronary Artery Disease-Reporting and Data System (CAD-RADS) score in patients' unknown diagnosis of coronary artery disease (CAD) underwent coronary CTA (Computed Tomography Angiography) and were classified by CAD-RADS scores. Materials and methods: A total of 187 patients consecutively referred for the evaluation of their chest pain underwent coronary CTA were included retrospectively. Results: CRP, CAR, and …
Clinicopathologic Comparisons Of Iga Nephropathy And Iga Vasculitis Nephropathy Inchildren: A Ten-Year Single-Center Experience, Qingxiao Su, Yuheng Liang, Na Wang, Zhiyan Dou, Zanhua Rong, Xue Zhao, Bo Yu, Yuxue Wang, Xinliang Wang
Clinicopathologic Comparisons Of Iga Nephropathy And Iga Vasculitis Nephropathy Inchildren: A Ten-Year Single-Center Experience, Qingxiao Su, Yuheng Liang, Na Wang, Zhiyan Dou, Zanhua Rong, Xue Zhao, Bo Yu, Yuxue Wang, Xinliang Wang
Turkish Journal of Medical Sciences
Background/aim: To investigate the similarities and differences of renal clinical and renal pathology between IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN) in children. Materials and methods: A total of 237 children with IgAN and 190 children with IgAVN were included. The general conditions, clinical characteristics, final diagnosis, clinical and pathological classification of the children were intercepted at the time of admission, and the retrospective comparative analysis was carried out. Results: The results showed that the median course of disease in IgAN group was longer than that in IgAVN group (p = 0.02). Patients with IgAN had a significantly higher …
The Role Of Circadian Rhythm In The Regulation Of Cellular Protein Profiles In The Brain, Mustafa Caglar Beker, Ertuğrul Kiliç
The Role Of Circadian Rhythm In The Regulation Of Cellular Protein Profiles In The Brain, Mustafa Caglar Beker, Ertuğrul Kiliç
Turkish Journal of Medical Sciences
Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, including Alzheimer's disease, Parkinson's disease, and ischemic stroke. Therefore, the identification of circadian rhythm-related proteins is crucial to be able to understand the molecular mechanism of the circadian rhythm and to define new therapeutic target for the treatment of degenerative disorders. Materials and methods: To identify the light and dark regulated proteins, 8-12 weeks, male Balb/C mice were used at two different time points (morning (Zeitgeber time-0 (ZT0)) …
The Protective Effect Of Boric Acid On Cholestatic Rat Liver Ischemia Reperfusion Injury, Serkan Güler, Ari̇f Aslaner, Hami̇t Yaşar Elli̇dağ, Şenay Yildirim, Tuğrul Çakir
The Protective Effect Of Boric Acid On Cholestatic Rat Liver Ischemia Reperfusion Injury, Serkan Güler, Ari̇f Aslaner, Hami̇t Yaşar Elli̇dağ, Şenay Yildirim, Tuğrul Çakir
Turkish Journal of Medical Sciences
Background/aim: To evaluate the potential protective effects of boric acid (BA) in experimental cholestatic liver ischemia reperfusion (IR) injury model. Materials and methods: The study included 24 female rats which were divided into 3 groups each containing 8 rats. The control group (Group 1) only received laparotomy. In the IR group (Group 2) biliary tract ligation was applied and 1 week later 45 min ischemia and 1 h reperfusion with relaparotomy without any treatment was implemented. In the treatment BA+IR group (Group 3). 1 week after the biliary ligation intraperitoneal administration of 200 mg/kg BA was given 10 min before …
What Is The Restorative Effect Of Vegf Inhibitor Bevacuzimab Against Subarachnoidhemorrhage In An Experimental Model?, Adnan Yalçin Demi̇rci̇, Yahya Güvenç, Ersi̇n Özeren, Çeti̇n Akyol, Pinar Bayram, Deni̇z Bi̇llur, Sevi̇m Aydin, Hakan Seçki̇n, Kazim Yi̇ği̇tkanli
What Is The Restorative Effect Of Vegf Inhibitor Bevacuzimab Against Subarachnoidhemorrhage In An Experimental Model?, Adnan Yalçin Demi̇rci̇, Yahya Güvenç, Ersi̇n Özeren, Çeti̇n Akyol, Pinar Bayram, Deni̇z Bi̇llur, Sevi̇m Aydin, Hakan Seçki̇n, Kazim Yi̇ği̇tkanli
Turkish Journal of Medical Sciences
Background/aim: This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Materials and methods: Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH+BVZ group (n = 6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ for 2 days after the SAH. Basilar artery diameters were measured with …
Antiinflammatory Effects Of Adalimumab, Tocilizumab, And Steroid Onlipopolysaccharide-Induced Lung Injury, Nurhan Sarioğlu, Fatma Bahar Sunay, Arzu Hanim Yay, Oğuzhan Korkut, Fuat Erel, Adnan Adi̇l Hi̇şmi̇oğullari, Mehmet Köse, Betül Yalçin
Antiinflammatory Effects Of Adalimumab, Tocilizumab, And Steroid Onlipopolysaccharide-Induced Lung Injury, Nurhan Sarioğlu, Fatma Bahar Sunay, Arzu Hanim Yay, Oğuzhan Korkut, Fuat Erel, Adnan Adi̇l Hi̇şmi̇oğullari, Mehmet Köse, Betül Yalçin
Turkish Journal of Medical Sciences
Background/aim: Acute lung injury (ALI) is a major cause of death in the intensive care unit. Lipopolysaccharide (LPS) induced lung injury is the most widely used experimental ALI model and provides opportunities for new targeting therapy. In this study, we investigated the effects of tocilizumab, adalimumab, and methylprednisolone in LPS-induced acute lung injury. Materials and methods: Lung injury was established by intratracheal instillation of LPS. The rats were randomly divided into six groups: LPS, control, and treatment groups (adalimumab, tocilizumab, methylprednisolone, adalimumab + tocilizumab). Bronchoalveolar lavage (BAL) and lung tissues were collected at 48 h and 96 h following LPS …
An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari
An Immunohistochemical Examination Of Cinnamon Extract Administration Ondistribution Of Ngf (Nerve Growth Factor) And Trk-A (Tyrosine Kinase-A) Receptor Fordiabetic Rats With Pancreatic Tissue, Şükran Yedi̇el Aras, Ebru Karadağ Sari
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the administration of cinnamon extract that is known to be effective in decreasing the high blood glucose and the distribution of NGF and Trk-A receptor in pancreas with immunohistochemistry way. Materials and methods: The experimental groups were defined as control, sham, cinnamon, diabetes, and diabetes-cinnamon. At the end of the experiment, the pancreatic tissue samples were obtained for the rats. The hematoxylin-eosin and triple staining were used to examine histology. The immunohistochemical methods were performed on the sections of pancreatic tissue. In all groups, the body weight and fasting blood glucose …
The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner
The Protective Effects Of Anakinra In A Neonatal Rat Model Of Necrotizing Enterocolitis, Hati̇ce Güneş, Sevcan İpek, Sadik Yurttutan, Tuncay Kuloğlu, Fatma İnanç Tolun, Ülkü Kazanci, Adem Doğaner
Turkish Journal of Medical Sciences
Background/aim: Necrotizing enterocolitis (NEC) is a commonly seen life-threatening condition in newborns characterized by ischemic necrosis. This study aimed to investigate anakinra's effects, an interleukin-1 receptor antagonist, on oxidative stress, inflammation, and tissue necrosis in an NEC rat model. Materials and methods: Forty Wistar albino pups were divided into four groups randomly as follows; group 1, control group; group 2, anakinra-treated control group; group 3, NEC group; and group 4, NEC and anakinra treatment group. The rats were given hyperosmolar formula feeding, and they were exposed to hypoxia after cold stress at +4 °C and oxygen in order to create …
Effect Of Coronavirus Pandemic On Organ Donation And Transplantation In Turkey, Emi̇ne Gülşah Torun, Mutlu Uysal Yazici
Effect Of Coronavirus Pandemic On Organ Donation And Transplantation In Turkey, Emi̇ne Gülşah Torun, Mutlu Uysal Yazici
Turkish Journal of Medical Sciences
No abstract provided.
Effects Of Bevacizumab Administration On The Hypoxia - Induced Pulmonaryhypertension Rat Model, Canan Demi̇r, Meral Karaman, Eyüp Sabri̇ Uçan, Ali̇ Necati̇ Gökmen, Duygu Gürel, Şadi̇ye Canan Çoker, Yasemen Adali, Osman Yilmaz
Effects Of Bevacizumab Administration On The Hypoxia - Induced Pulmonaryhypertension Rat Model, Canan Demi̇r, Meral Karaman, Eyüp Sabri̇ Uçan, Ali̇ Necati̇ Gökmen, Duygu Gürel, Şadi̇ye Canan Çoker, Yasemen Adali, Osman Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia - induced pulmonary hypertension (PH) rat model. Materials and methods: 24 adult Wistar Albino rats were randomly divided into four groups: control group - saline; Bevacizumab Group; PH Group; PH + Bevacizumab Group. In hypoxia - induced model, 10% oxygen and 90% nitrogen were applied in a plexiglas box for eight days to PH Group and PH + …