Engineering Commons^™

Improving Nano-Drug Delivery By Using Near-Real Time Sensing And Feedback, Pratik Adhikari

Doctoral Dissertations

Personalized medicine, seen as the solution to address the variability among the individuals, is the movement which proposes customization of medical procedures based on the need of the patient during the stages of prevention, diagnosis, treatment, and follow up. As the technology in medicine expands and newer methods of diagnosis and treatment are introduced in the clinic, real time data from the procedures is critical to assess the performance at point of care. Real time feedback, through collection of data at point of care would help make informed clinical decisions, potentially improving the efficacy of the treatment. In this dissertation, …

Electron Beam Induced Deposition Of Highly Conductive Copper Nanowires From Bulk Liquids, Amjad M. Syam

Theses and Dissertations--Electrical and Computer Engineering

Electron-beam induced deposition (EBID) is a position-controlled technique that can directly fabricate nanometer-sized structures in functional materials. In the standard process, a gaseous precursor delivers the desired substance to the substrate for deposition. However, the material purity from these precursors is typically poor, which often negatively affects the functional properties of the deposit. Recently, bulk liquid precursors have been investigated as promising reactants for high purity deposition without the need for post-processing. In this work, EBID from bulk liquids is shown to yield highly conductive nanowire deposits. Aqueous solutions containing copper sulfate (CuSO₄) and sulfuric acid (H_{2 …}

Size Specific Transfection To Mammalian Cells By Micropillar Array Electroporation, Yingbo Zu

Doctoral Dissertations

Electroporation serves as a promising non-viral gene delivery approach, while its current configurations carry drawbacks associated with high-voltage electrical pulses and heterogeneous treatment on individual cells. Here, we developed a new micropillar array electroporation (MAE) platform to advance the delivery of plasmid DNA and RNA to mammalian cells. By introducing well-patterned micropillar array on the electrode surface, the number of pillars each cell faces varies with its cell membrane surface area, despite their large population and random locations. In this way, cell size specific electroporation is conveniently done and contributed to a 2.5~3 fold increase on plasmid DNA transfection and …

Development And Application Of Urban Landslide Vulnerability Assessment Methodology Reflecting Social And Economic Variables, Yoonkyung Park, Ananta Man Singh Pradhan, Ungtae Kim, Yun-Tae Kim, Sangdan Kim

Civil and Environmental Engineering Faculty Publications

An urban landslide vulnerability assessment methodology is proposed with major focus on considering urban social and economic aspects. The proposed methodology was developed based on the landslide susceptibility maps that Korean Forest Service utilizes to identify landslide source areas. Frist, debris flows are propagated to urban areas from such source areas by Flow-R (flow path assessment of gravitational hazards at a regional scale), and then urban vulnerability is assessed by two categories: physical and socioeconomic aspect. The physical vulnerability is related to buildings that can be impacted by a landslide event. This study considered two popular building structure types, reinforced-concrete …

Timing And Carrier Synchronization In Wireless Communication Systems: A Survey And Classification Of Research In The Last 5 Years, Ali A. Nasir, Salman Durrani, Hani Mehrpouyan, Steven D. Blostein, Rodney A. Kennedy

Electrical and Computer Engineering Faculty Publications and Presentations

Timing and carrier synchronization is a fundamental requirement for any wireless communication system to work properly. Timing synchronization is the process by which a receiver node determines the correct instants of time at which to sample the incoming signal. Carrier synchronization is the process by which a receiver adapts the frequency and phase of its local carrier oscillator with those of the received signal. In this paper, we survey the literature over the last 5 years (2010–2014) and present a comprehensive literature review and classification of the recent research progress in achieving timing and carrier synchronization in single-input single-output (SISO), …

Revealing Student Misconceptions And Instructor Blind Spots With Muddiest Point Formative Feedback, Cindy Waters, Stephen J. Krause, Janet Callahan, Barry Dupen, Mary B. Vollaro, Peggie Weeks

Materials Science and Engineering Faculty Publications and Presentations

Of interest to all engineering disciplines, well-designed formative feedback has the potential to enhance both instructor teaching and student learning. Delivering fundamental courses year after year, can ultimately lead faculty to use stale notes or slides from past years. This approach may save time, but does not meet the shifting needs of our students who have high expectations from their instructors. One simple method to improve teaching is to employ muddiest point reflections. Muddiest point reflections involve simply asking students to anonymously reflect on what was “muddy”, i.e. confusing, during class and to rank their level of confusion which not …

Carbon Dioxide Adsorption Studies On Fly Ash Zeolites, Denitza Zgureva

Coal Combustion and Gasification Products Journal Archive

In this study, the potential of fly ash zeolites (FAZ) Linde (LTA) and faujasite (FAU) to adsorb carbon dioxide (CO2) was investigated in view of the results of implementation in postcombustion carbon-capture technologies. Adsorption isotherms of selected samples were measured at 273.15 K by a Micromeritics Tristar II 3020 surface analyzer. The highest adsorption capacity was obtained for FAZ with a FAU structure synthesized by a two-stage fusion hydrothermal process from fly ash (FA) that was composed of 65 wt% amorphous components. The adsorption capacity for this sample reached a value of 136.40 mg CO2/g FAZ at atmospheric pressure, a …

Analysis Of Scientific Investigations Related To Reclamation Of Surface Mining Control And Reclamation Act Permitted Coal Mines With Coal Combustion By-Products, Kimery C. Vories

Coal Combustion and Gasification Products Journal Archive

In the United states, the placement of coal combustion by-products (CCBs) (i.e., fly ash, bottom ash, boiler slag, flue gas desulfurization material, and fluidized bed combustion material) in coal mines has been an area of controversy. Federal and state governments, universities, the National Energy Technology Laboratory, and industrial research organizations have taken an active role in encouraging and promoting technological advances, research, and technology transfer related to the use of CCBs at coal mines. CCBs have been placed at Surface Mining Control and Reclamation Act of 1977 (SMCRA) permitted mines since 1977 to serve the following purposes: (1) a seal …

Coal Ash By-Product From Shanxi Province, China, For The Production Of Portland–Calcium Sulfoaluminate, Tristana Y. Duvallet, Thomas L. Robl, Kevin R. Henke, Yongmin Zhou, David Harris

Coal Combustion and Gasification Products Journal Archive

Twenty bulk samples were collected from ponded coal combustion ash in Shanxi Province, China, as part of an investigation of their beneficiation potential. The samples were shipped to the University of Kentucky, where they were chemically analyzed. The samples were highly consistent in chemistry, falling within the ASTM C-618 class F compositional range. The particle size of the ponded ash was relatively coarse, with only ,7% by weight on average, falling below 200 mesh (75 mm) particle size. The bulk of the material (.80%) was within 50 by 200 mesh (equivalent to 300 by 75 mm). X-ray diffraction investigation combined …

Effect Of Coal Fly Ash Leachate On The Bioluminescence Intensity Of Vibrio Fischeri, Shiro Ikeda, Irena Kostova, Hideaki Sekine, Yoshika Sekine

Coal Combustion and Gasification Products Journal Archive

Coal fly ash is a residue of coal-fired thermoelectric power plants (TPPs) and is mostly dumped in ash ponds or landfill sites, even though it potentially contains significant amounts of water-soluble hazardous contaminants. Bioassay using the bioluminescent bacterium *Vibrio fischeri* is known to be applicable for assessing the short-term and sublethal toxicity of complex mixtures without the need for precise chemical characterization. However, this type of bioassay is potentially adversely influenced by the pH-induced protein denaturation of cells. Because coal fly ash leachates often have alkaline or acidic properties, when applying the *V. fischeri*-based bioassay to the samples, we need …

Influence Of Coal-Fired Power Plant Emissions Regulations And Consequent Engineering Controls And Coal-Supply Modifications On Fly Ash Chemistry And Petrology: Examples From Kentucky Power Plants, Madison M. Hood, John G. Groppo, Michelle N. Johnston, James C. Hower, Herek L. Clack, Diego S. De Medeiros, Silvio R. Taffarel, Cesar M.N.L. Cutruneo, Luis F.O. Silva

Coal Combustion and Gasification Products Journal Archive

The chemistry and petrology of fly ash are controlled by a number of factors: (1) chemistry of the feed coal (and added fuels, such as petroleum coke, tires, biomass, etc.), (2) particle size of the fuel feed (controlled by pulverized fuel vs. cyclone combustion, maintenance of pulverizers, etc.), (3) design of the boiler and pollution-control system, and (4) temperature of the flue gas at the collection point. In general, for any electrostatic precipitator or baghouse system, the concentrations of volatile trace elements in fly ash will increase with a drop in the flue gas temperature and a decrease in the …

Cardiovascular Dieseases: From Data Generation To Analysis, Thomas Wischgoll

Computer Science and Engineering Faculty Publications

Cardiovascular diseases remain the leading cause of death in Western societies. This presentation will provide insight into the use of expert knowledge and models to derive diagnostic tools that have the potential to aid in the diagnosis of diffuse cardiovascular diseases that tend to be more difficult to detect in CT angiograms. In order to develop these methods more basic research is needed to prove the validity of the approach, including validation of accuracy as well as approach itself. For that, specimens of porcine hearts were prepared and then analyzed followed by a statistical comparison between computed and optical measurements. …

A Semi-Automated Computer Program For Assessment Of Skeletal Maturity In Children, Sara Gharabaghi, Thomas Wischgoll

Computer Science and Engineering Faculty Publications

In pediatric patients, skeletal maturity is an important tool for detection of hormonal, growth or genetic disorders. The Fels method is a well-known visual assessment method in which the skeletal age is estimated by grading 98 skeletal indicators in the hand-wrist radiographic (x-ray) image. These indicators are features that reflect the three-dimensional shape of the bones and change during the maturation process. Generally, the Fels indicators could be categorized into three main groups of the status of ossification, the ratios of bone widths, and epiphysealdiaphyseal fusion.

Stimulus And Optode Placement Effects On Functional Near-Infrared Spectroscopy Of Visual Cortex, Nasser H. Kashou, Brenna M. Giacherio

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Functional near-infrared spectroscopy has yet to be implemented as a stand-alone technique within an ophthalmology clinical setting, despite its promising advantages. The present study aims to further investigate reliability of visual cortical signals. This was achieved by: (1) assessing the effects of optode placements using the 10–20 International System of Electrode Placement consisting of 28 channels, (2) determining effects of stimulus size on response, and (3) evaluating response variability as a result of cap placement across three sessions. Ten participants with mean age 23.8 4.8 years (five male) and varying types of hair color and thickness were recruited. Visual stimuli …

Hand-Grasping And Finger Tapping Induced Similar Functional Near-Infrared Spectroscopy Cortical Responses, Nasser H. Kashou, Brenna M. Giacherio, Ramzi W. Nahhas, Sudarshan R. Jadcherla

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Despite promising advantages such as low cost and portability of functional near-infrared spectroscopy (fNIRS), it has yet to be widely implemented outside of basic research. Specifically, fNIRS has yet to be proven as a standalone tool within a clinical setting. The objective of this study was to assess hemodynamic concentration changes at the primary and premotor motor cortices as a result of simple whole-hand grasping and sequential finger-opposition (tapping) tasks. These tasks were repeated over 3 days in a randomized manner. Ten healthy young adults (23.8 4.8 years) participated in the study. Quantitatively, no statistically significant differences were discovered between …

Finite Element Analysis Of Superior C3 Cervical Vertebra Endplate And Cancellous Core Under Static Loads, Isaac Mabe, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Subsidence is a type of failure associated with implanted cervical cages or artificial intervertebral discs. It is defined as a loss of postoperative disc height. Actuarial rates show a risk of subsidence at 16 weeks at 70.7 percent. This study examines the changes in the vertebral endplate morphology and the resulting effect on the stresses developed in the endplate and in the vertebral core. A three-dimensional linear elastic model was created from computed tomographic (CT) scans and material properties were assigned according to various studies. Particular care was taken in the superior endplate that was modeled according to experimental measurements. …

Analysis Of A Clinically Failed, Mechanically Intact, Hemi-Toe Implant, Swetha Varadharajan, Richard T. Laughlin, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

In this case study a clinically failed, mechanically intact, hemi-toe device was investigated. The clinical indication of the failure constitutes radiolucent line indicating loosening of the implant and possible interactions among the bone-implant initiated by osteolysis may become a factor, producing pain, inflammatory reactions, deformity and discomfort. The patient file was not available to determine these parameters. The device was titanium coated, Cobalt Chromium alloy used for making hemi-toe. Degeneration of hemi implant was due to spalling of the coating from the surface, causing loosening of stem from bone. However, pre-removal X-ray films were not available to confirm. Mechanism by …

Personalized And Adaptive Semantic Information Filtering For Social Media, Pavan Kapanipathi

Browse all Theses and Dissertations

Social media has experienced immense growth in recent times. These platforms are becoming increasingly common for information seeking and consumption, and as part of its growing popularity, information overload pose a significant challenge to users. For instance, Twitter alone generates around 500 million tweets per day and it is impractical for users to have to parse through such an enormous stream to find information that are interesting to them. This situation necessitates efficient personalized filtering mechanisms for users to consume relevant, interesting information from social media. Building a personalized filtering system involves understanding users' interests and utilizing these interests to …

Aligned Carbon Nanotube Carpets On Carbon Substrates For High Power Electronic Applications, Betty Tun-Huan Quinton

Browse all Theses and Dissertations

Abstract Quinton, Betty Tun-Huan. Ph.D., Engineering Ph.D. Program, Wright State University, 2016. Aligned Carbon Nanotube Carpets On Carbon Substrates for High Power Electronic Applications. One of the driving forces behind nanotechnology research is the miniaturization of electronic devices. Electrical and thermal transport properties of device materials at micrometer and nanometer scales become very important in such applications. Carbon materials, especially carbon nanotubes (CNTs), have exceptionally low density and superior electrical, thermal, and mechanical properties. Vertically aligned CNTs attached to lightweight carbon substrates may hold the key to fully use these outstanding properties. However, the majority of studies reported to date …

Detecting Php-Based Cross-Site Scripting Vulnerabilities Using Static Program Analysis, Steven M. Kelbley

Browse all Theses and Dissertations

With the widespread adoption of dynamic web applications in recent years, a number of threats to the security of these applications have emerged as significant challenges for application developers. The security of developed applications has become a higher priority for both developers and their employers as cyber attacks become increasingly more prevalent and damaging. Some of the most used web application frameworks are written in PHP and have become major targets due to the large number of servers running these applications worldwide. A number of tools exist to evaluate PHP code for issues, however most of these applications are not …

Data Mining And Mathematical Models For Direct Market Campaign Optimization For Fred Meyer Jewelers, Lebin Lin

Browse all Theses and Dissertations

Jewelry retail companies like Fred Meyer Jewelers employ direct marketing such as mailing lists and catalogs as a primary means to promote products, maintain customer relationships, and drive sale growths. Most jewelry customers, however, do not purchase frequently – they make only a limited number of purchases at special times with long lead-times between purchases. This has created a series of challenging problems for the marketing team at these jewelry stores in a) predicting when and what the customer purchases, and b) deciding what customers to be targeted so as to maximize the return on investment in the design of …

Miniatured Inertial Motion And Position Tracking And Visualization Systems Using Android Wear Platform, Dhruvkumar Navinchandra Patel

Browse all Theses and Dissertations

In this thesis, we have designed and developed a motion tracking and visualization system using the latest motion tracking sensory technologies. It is one of the enabling technologies for our novel visual-inertial odometer and human anatomy based 3D Locating, Mapping and Navigation system for endoscopy and drug delivery capsules used inside GI tract. In particular, we have: i) designed and completed a cloud-based sensory data collecting, processing and storage system to provide the reliable computing and storage platform; ii) explored different data processing methods to obtain improved-quality motion results from extremely noisy raw data, e.g., by using a low pass …

Low-Cost, Wireless Optical Oximeter For Monitoring Of Brain Function In High-Risk Pediatric Population, Zahra Meghjani

Browse all Theses and Dissertations

Nearly 4 million neonates die every year due to brain injuries, most caused by hypoxia. Neonatal ICU requires newborns with critical health conditions to be monitored continuously calling for the need of a non-invasive, compact and portable device. However, commercial devices are mostly bulky and/or expensive. The neonatal mortality is higher in under-developed countries, where such expensive and large devices are not affordable. Hence, my thesis focuses on building first generation compact, inexpensive, and wireless device that can monitor and provide feedback to clinicians during intervention. This approach is based on light absorption by oxy- and deoxy-hemoglobin chromophores. The total …

Synthesis, Device Fabrication, And Characterization Of Two-Dimensional Molybdenum Disulfide, Gustavo Alberto Lara Saenz

Open Access Theses & Dissertations

The miniaturization of electronic devices according to Moore's Law has been propelled by the continuous demand for faster and smaller devices which continue to advance technology. One recent contribution to this trend was the isolation and characterization of one atom thick of graphite, known as graphene, which led to the Nobel Prize in physics in 2010 being awarded to Andre Geim and Konstantin Novoselov. Graphene and its related nanocarbon derivatives have exceptional mechanical, thermal, optical and electronic properties, making them a potential candidate for electronics and optoelectronics applications. However, this material has no intrinsic bandgap and complicated processes are required …

Development Of The Thermal Wire Embedding Technology For Electronic And Mechanical Applications On Fdm-Printed Parts, Daniel Abraham Marquez

Open Access Theses & Dissertations

Additive Manufacturing (AM) has increased in popularity and attracted much attention from many fields such as automotive, aviation, aerospace, and even the fashion industry. Since the early 2000s, Fused Deposition Modeling (FDM) technologies have been the most popular in the AM world ("Wohlers Talk" Popularity of FDM). These technologies have been mainly used for building parts for prototype and structural type of applications such as a fixture for components or a housing for mechanisms.

With the current state of the FDM technologies, the functionality of the parts that are printed are limited to the applications listed before or simply just …

Implementation Of New System For Oxygen Generation And Carbon Dioxide Removal, Angelo Peter Karavolos

Open Access Theses & Dissertations

This research effort develops an integrated system for CO2 removal and O2 production. A unique material, dodeca-tungsto-phosphoric acid (H3PO4W12O3; henceforth referred to as DTPA) is mixed with tetra-ethyl-ortho-silicate Si(OC2H5)4 or TEOS. This mixture exhibits unique properties of heat absorption and high electrical conductivity. In the system described herein, the DTPA resides within a cross linked arrangement of TEOS. The DTPA furnishes a source of O2, while the TEOS furnishes structural support for the large DTPA crystals. In addition, the large amount of H2O within the crystal also adsorbs CO2. It can also be cross-linked with other polymers such as polycarbonate, …

Structural Design Of Liquid Oxygen/Liquid Methane Robotic Lander Janus, Mariana Chaidez

Open Access Theses & Dissertations

As the attempt to send humans to Mars has gained momentum in the last decade, the need to find alternative propellants that are safer, less toxic, and yields a better performance has become apparent [1]. Liquid methane and oxygen have emerged as a suitable alternative. In addition, the incorporation of liquid methane/liquid oxygen into the propulsion system has demonstrated an increase in engine performance, as well as a reduction in the volume, size and complexity of the propulsion system. In an attempt to further understand the technologies that are possible to develop using liquid oxygen (LO2) and liquid methane (LCH4), …

Vascularization In Interconnected 3d Printed Ti-6al-4v Foams With Hydrogel Matrix For Biomedical Bone Replacement Implants, Victor Correa

Open Access Theses & Dissertations

Abstract:

Vascularization or angiogenesis on newly implanted metal orthopedic implants has remained a challenge in the field of tissue engineering. In this research, an interconnected foam structure of Ti-6Al-4V was micro-fabricated by Electron Beam Melting (EBM) technique. The foam in question has a density of 1.77g/cm3 with 60% porosity and a tensile strength of 18GPa. An Extracellular Matrix based hydrogel was added as an aqueous matrix to the foam in question. Hypoxia mimetic stress has been closely related to many wound healing biomedical applications as it increases survival and proliferation molecular signals. To that end, increased expression of Hypoxia-Inducible Factor-1α …

Characterization Of High Intensity Turbulent Flows Through Time Resolved Particle Image Velocimetry In A Backward Facing Step Combustor, Martin De La Torre

Open Access Theses & Dissertations

The fundamental understanding of turbulent premixed combustion has taken place as one of the major research topics of interest in industry thanks to advancements in kHz level laser diagnostics such as in Particle Image Velocimetry (PIV) and Planar Laser Induced Fluorescence (PLIF). Because of said advancements in this technology researchers and the scientific community are now able to expand their understanding of flame studies at high turbulence conditions to acquire a better understanding, and improve models used in turbine design, scram/ram jets, rocket engines, and emissions control. This surge of new technologies has made this topic a high priority one …

Development And Initial Testing Of A Low-Cost, Electronic, Microprocessor-Controlled Prosthetic Knee, Lucas Jonathan Galey

Open Access Theses & Dissertations

Cost-effective lower-limb prostheses have been successful in restoring mobility, independence, and a way of life to millions of global amputees who do not have the means to afford more sophisticated prosthetics. Comprehensively, the current above knee (AK) prosthetic market is segmented into two extremes â?? very affordable relief style knees that offer basic functionality with high risk of accident due to falls, and very expensive styles that offer electronic microprocessor stumble control and adaptive cadence. There remains a gap for a middle-ground system that provides stumble control and greater stability within an achievable price bracket for the developing world. This …