Engineering Commons^™

Effect Of Agitation On Protein Aggregation In Vials Made From Glass Or Plastics, Birgit Mueller-Chorus, Erica Tullo, Vinod Vilivalam, Lloyd Waxman

Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications

The increasing use of proteins as therapeutics including monoclonal antibodies has focused attention on the need to maintain the stability of these labile molecules during both storage and shipment. The degradation of therapeutic proteins can arise from aggregation and adsorption in primary containers, as well as from exposure to leachables, and chemical damage due to exposure to oxygen or light. Since vials continue to be used as primary containers for multiple-use applications, including vaccines and lyophilized drug products, we have compared the effect of mechanical stress on protein aggregation in vials made of glass versus vials made of the plastic …

Particulate Contamination In Single Use Systems: Measurement Challenges, Klaus Wormuth, Fanny Gaston, Mathieu Labedan

Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications

In conventional biopharmaceutical processes using stainless steel components, the pharmaceutical manufacturer is responsible for process cleanliness. However for single use systems, the pharmaceutical manufacturer “outsources” process cleanliness to the manufacturer of the single use systems, since no rinsing or cleaning occurs prior to implementation. Especially critical applications such as final fill and finish or aseptic processes demand a high degree of cleanliness with respect to particulate contamination. Although single use component assembly occurs in carefully controlled cleanroom environments, risks arise for particulate contamination from incoming components, cutting and welding operations, and human activity during manually intensive assembly processes. While visual …

Conference Program, Ekta Mahajan, Gary Lye, Regine Eibl-Schindler

Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications

No abstract provided.

Characterization Of Silicone Tubing – Effect Of Pressure And Irradiation On Tubing Diameter, Lise Tan-Sien-Hee, Csilla Kollar, Andrew Diehl, Ernie Jenness, Pietro Perrone

Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications

A Single-Use assembly or system consists of numerous flexible components connected together via heat seals, overmolds or mechanical fasteners. The integrity (e.g. leak assurance) of such a system is dependent on the internal surface being continuously sealed and free of disconnects between the various components. The diameter of the flexible tubing during manufacture of the assemblies and the tubing expansion at operational pressures are important characteristics to know. Understanding these factors can help in the design of assemblies that maintain their integrity throughout their use at operating conditions. The aim of the study was to characterize four different tubing types …

Improving Single Use Bioreactor Design And Process Development Using The Hyperforma 5:1 S.U.B, Michael Goodwin

Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications

Operating bioreactor vessels at low working volumes (high turn-down ratio) is often desirable but brings about challenges in regard to mixing, mass transfer, and process control. Research done towards optimizing cell culture has provided methods to improve performance and control when operating under these special conditions.  Impacts of enhanced energy transfer-Implementing bottom heat exchange, alternate impeller positions, and considering agitation dissipation rates.  Maximizing your platform-Taking advantage of the unique Thermo Fisher Scientific Drilled Hole Sparge design and implementing a new Cross Flow Sparge into the headspace have yielded reliable mass transfer and cell culture results from 10-2000L working …

Life Cycle Sustainability Analysis (Lcsa) Of Polymer-Based Piping For Plumbing Applications, Andy J. Rivas Bolivar

Senior Honors Projects, 2010-2019

Water conveyance systems play a critical role in modern developed areas. Polymer pipes have been used for about a century, and their convenient physical properties have positioned polymers as the leading material in the piping industry. Having such influence in the market means that changes in current material selection and manufacturing could lead to significant reductions in the footprint associated with their products. Currently, there are no comparative lifecycle assessments that evaluate the different polymer selections commercially available, which makes it hard to determine what products have the least impact on the environment. Understanding how such impacts are relative to …

Process Development And Implementation For The Imaging Of Heat Treated A2 Steel For Consolidation Into An Atlas, Jessica Roberts

Senior Honors Projects, 2010-2019

Material processes, properties, and microstructure are interconnected, often visualized as the points of a triangle. Changing the process a material goes through will in turn change the properties and microstructure of that material. In materials research and education (specifically with metals), comparison between research or experiment results and scholarly-accepted results is important. When reading textbooks addressing different properties of metals and the process of metal treatment, images are often shown of the various microstructures associated with each property or process stage. The difficulty comes in trying to compare the stages or properties to one another; often different materials and processes …

Experimental Analysis Of R134a, R22, And R404 For An Edibon Taab: Air Conditioning Lab Unit, Kyle T. Heesen

Senior Honors Projects, 2010-2019

This paper presents an experimental analysis of an Ebidon® TAABTM: Air Conditioning Lab unit running on R-134a being compared with R22 and R404 refrigerants, a $24,449 piece of equipment purchased by the JMU ISAT Department. In this paper we will compare the performance of the R-134a refrigerant under a range of working conditions and compare them to how the system would run on R22 or R404. The experimental tests use varying fan speeds and the R-134a data collected is compared to simulated data collected for R22 and R404. Analysis of the collected data and simulated data will be compared on …

Living Tiny Legally, James G. Rollin

Senior Honors Projects, 2010-2019

Over the last 40 years, the average new United States house has increased in size by more than 1,000 square feet, from an average size of 1,660 square feet in 1973 (earliest year available from the Census Bureau) to 2,687 square feet last year (Perry, 2016). In that same time period, there was a 91% increase in home square footage per inhabitant and a decrease in average household size. According to the U.S. Census Bureau, the average home in the United States costs approximately $358,000 to build, an increase of roughly $200,000 since 1998. Meanwhile, the average annual income in …

Carbon Particles, Stephen M. Lipka, Christopher R. Swartz

Center for Applied Energy Research Faculty Patents

A composition generally includes carbon particles. The particles are prepared by dissolving a carbohydrate-based precursor in water to form a precursor solution and placing the precursor solution in a pressure vessel. The precursor solution is placed in a pressure vessel. The pressure vessel is heated to a reaction temperature to form carbon particles. The carbon particles are subjected to a chemical activation and a physical activation. The composition includes, by weight, about 5% to about 30% oxygen.

Toward Measuring Network Aesthetics Based On Symmetry, Zengqiang Chen, Matthias Dehmer, Frank Emmert-Streib, Abbe Mowshowitz, Yongtang Shi

Publications and Research

In this exploratory paper, we discuss quantitative graph-theoretical measures of network aesthetics. Related work in this area has typically focused on geometrical features (e.g., line crossings or edge bendiness) of drawings or visual representations of graphs which purportedly affect an observer’s perception. Here we take a very different approach, abandoning reliance on geometrical properties, and apply information-theoretic measures to abstract graphs and networks directly (rather than to their visual representaions) as a means of capturing classical appreciation of structural symmetry. Examples are used solely to motivate the approach to measurement, and to elucidate our symmetry-based mathematical theory of network aesthetics.

Investigating The Classical And Non-Classical Mechanical Properties Of Gan Nanowires, Mohammad Reza Zamani Kouhpanji

Electrical and Computer Engineering ETDs

Study and prediction of classical and non-classical mechanical properties of GaN is crucial due to the potential application of GaN nanowires (NWs) in piezoelectric, probe-based nanometrology, and nanolithography areas. GaN is mainly grown on sapphire substrates whose lattice constant and thermal expansion coefficient are significantly different from GaN. These discrepancies cause mechanical defects and high residual stresses and strains in GaN, which reduce its quantum efficiency.

Specifically, for nanoscale applications, the mechanical properties of materials differ significantly compared to the bulk properties due to size-effects. Therefore, it is essential to investigate the mechanical properties of GaN NWs using the non-classical …

An Experimental Study On Drag Reduction Of Aftermarket Additions On An Suv, Christiana L. Katsoulos

Senior Honors Projects, 2010-2019

Over recent years, the awareness of climate change has become more prevalent worldwide and one major contributor to global warming has been the use of transportation. Vehicles contribute to global warming by releasing petroleum based emissions such as significant amounts of carbon dioxide and numerous other harmful environmental pollutants. SUVs contribute to the emissions problem more so than sedans, since they have lower gas mileage and need more gasoline regularly. The main functionality of sport utility vehicles, or SUVs, includes hauling or off-roading and fuel efficiency is not always the focus in the design process. However, aerodynamic enhancements could improve …

Technology From The Perspective Of Society And Public Interest, Chanwoon Park

Purdue Polytechnic Doctoral Dissertations

The ultimate goals of this study were to determine ways to reconcile technology with public interest and to understand the relationship between what we know and how we feel about technology. To achieve the goals, related literatures were reviewed; the mechanism of technology development was described with empirical data; and human perception of technology was tested with a survey. The duality of technology that implied technological inherencies of technical reason and social meanings was the principle assumption of the study. Neutrality of technology becomes a myth with the presence of social meanings embodied in technology. Given the huge impact of …

Study Of Knowledge-Based System (Kbs) And Decision Making Methodologies In Materials Selection For Lightweight Aircraft Metallic Structures, Pashupati R. Adhikari, Reza Mirshams

Journal of Applied Science & Engineering Technology

This paper presents an overview of knowledge-based system (KBS) in the context of decision making methodologies used in materials selection for the design of light weight aircraft metallic structures. Overall aircraft weight reduction means substantially less fuel consumption and better efficiency. Part of the solution to this problem is to find a way to reduce overall weight of metallic structures in the aircraft. Two distinct multiple criteria decision making (MCDM) methodologies are presented with examples featuring a set of short-listed materials suitable in the design of the structures. Pre-defined constraint values, mainly mechanical properties, are employed as relevant attributes satisfying …

A Novel Technique For Designing High Power Semiconductor Optical Amplifier (Soa)-Based Tunable Fiber Compound-Ring Lasers Using Low Power Optical Components, Muhammad A. Ummy, Simeon Bikorimana, Roger Dorsinville

Publications and Research

A simple, stable and inexpensive dual-output port widely tunable semiconductor optical amplifier (SOA)-based fiber compound-ring laser structure is demonstrated. This unique nested ring cavity enables high optical power to split into different branches where amplification and wavelength selection are achieved by using low-power SOAs and a tunable filter. Furthermore, two Sagnac loop mirrors, which are spliced at the two ends of the compound-ring cavity not only serve as variable reflectors but also channel the optical energy back to the same port without using any high optical power combiner. We propose and discuss how the demonstrated fiber compound-ring laser structure can …

Children's Law Center Site Redevelopment, Caroline Olivia Haggard, Javonte Isaac, Joshua Joslin, E'Lexus Nelson, Ana Vieira, Adrien Williams, David Zalla

Senior Theses

Soda City Engineering and Consulting was contracted by the USC School of Law to redevelop the Children’s Law Center site in Columbia, SC. Currently, the site does not comply with current standards and specifications. The objective of this project is to completely redevelop the site with a new annex building and ensuring everything is up to code, while still allowing the historic structure to maintain its use throughout construction.

Behavior-Based Freight Modeling At Metro, Chris Johnson, Bud Reiff

PSU Transportation Seminars

Chris Johnson and Bud Reiff will present on a behavior-based freight model being used at Oregon Metro. This model will replace Metro’s current truck model with a hybrid freight model that both represents multi-modal freight flows through elements of national and regional supply chains and simulates the movement of individual trucks and shipments on local networks. Model estimation and calibration will also require collection of behavioral data from shippers and receivers representing a wide range of industries, common and contract freight carriers, business that operate non-freight commercial vehicles, warehouse managers, and logistics agents.

Key project objectives:

• Develop tools to enable …

Interactions Of A Co-Rotating Vortex Pair At Multiple Offsets, Kyle Forster, Tracie Barber, Sammy Diasinos, Graham Doig

Aerospace Engineering

Two NACA0012 vanes at various lateral offsets were investigated by wind tunnel testing to observe the interactions between the streamwise vortices. The vanes were separated by nine chord lengths in the streamwise direction to allow the upstream vortex to impact on the downstream geometry. These vanes were evaluated at an angle of incidence of 8° and a Reynolds number of 7 x 10⁴ using particle image velocimetry. A helical motion of the vortices was observed, with rotational rate increasing as the offset was reduced to the point of vortex merging. Downstream meandering of the weaker vortex was found to …

Fluid Isolator, Purdue Ect Team

ECT Fact Sheets Archive

The reliability of concrete infrastructure is vital to ensuring daily life, as well as commerce, can progress without interruption. From the pavement of interstate highways to the driveways and sidewalks in a local neighborhood, concrete is expensive to install and often even more expensive, and intrusive, when it needs to be replaced. Unfortunately, to maintain functionality in winter climates concrete is heavily exposed to deicing salts. This not only affects the roads, driveways, and sidewalks where salt is applied directly, but many other areas such as parking and residential garages where vehicles (and people) will track salt along with water …

Netpoint®, Purdue Ect Team

ECT Fact Sheets Archive

The vast majority of construction scheduling software uses a combination of spreadsheets and Gantt charts for developing and depicting Critical Path Method (CPM) schedules. While this paradigm works for the expert scheduler, it is not conducive to collaboration, and it is prohibitively difficult for non-scheduling experts to understand.

NetPoint® provides a dynamic, visual interface conducive to touch and gestural input. Activities are drawn directly on a time-scale and may be placed on the same row or arranged automatically using codes or the WBS. Such control of the presentation makes it easier to communicate the plan to any type of audience. …

Tum: Towards Ubiquitous Multi-Device Localization For Cross-Device Interaction, Han Xu, Zheng Yang, Zimu Zhou, Ke Yi, Chunyi Peng

Research Collection School Of Computing and Information Systems

Cross-device interaction is becoming an increasingly hot topic as we often have multiple devices at our immediate disposal in this era of mobile computing. Various cross-device applications such as file sharing, multi-screen display, and crossdevice authentication have been proposed and investigated. However, one of the most fundamental enablers remains unsolved: How to achieve ubiquitous multi-device localization? Though pioneer efforts have resorted to gesture-assisted or sensing-assisted localization, they either require extensive user participation or impose some strong assumptions on device sensing abilities. This introduces extra costs and constraints, and thus degrades their practicality. To overcome these limitations, we propose TUM, an …

College Of Engineering Senior Design Competition Spring 2017, University Of Nevada, Las Vegas

Fred and Harriet Cox Senior Design Competition Projects

Part of every UNLV engineering student’s academic experience, the senior design project stimulates engineering innovation and entrepreneurship. Each student in their senior year chooses, plans, designs, and prototypes a product in this required element of the curriculum. A capstone to the student’s educational career, the senior design project encourages the student to use everything learned in the engineering program to create a practical, real world solution to an engineering challenge. The senior design competition helps focus the senior students in increasing the quality and potential for commercial application for their design projects. Judges from local industry evaluate the projects on …

Mechanical Engineering News, Georgia Southern University

Mechanical Engineering: News & Publications (2013-2023)

No abstract provided.

Using Phase For Radar Scatterer Classification, Linda J. Moore, Brian D. Rigling, Robert Penno, Edmund G. Zelnio

Electrical and Computer Engineering Faculty Publications

Traditional synthetic aperture radar (SAR) systems tend to discard phase information of formed complex radar imagery prior to automatic target recognition (ATR). This practice has historically been driven by available hardware storage, processing capabilities, and data link capacity. Recent advances in high performance computing (HPC) have enabled extremely dense storage and processing solutions. Therefore, previous motives for discarding radar phase information in ATR applications have been mitigated. First, we characterize the value of phase in one-dimensional (1-D) radar range profiles with respect to the ability to correctly estimate target features, which are currently employed in ATR algorithms for target discrimination. …

Brake Specific Fuel Consumption (Bsfc) In Gasoline Powered Cars, Michael Carlson, Dr. Cecilia J. Vogel

Celebration of Learning

The goal of this experiment was to determine which driving behaviors result in the highest fuel efficiency for a given trip. We collected data for speed (MPH), engine speed (RPM), engine power (Torque/LOD), and fuel consumption (MPG) using the ScanGauge II.

Length Of Need And Minimum System Length For F-Shape Portable Concrete Barrier, Robert W. Bielenberg, Dylan T. Meyer, Ronald K. Faller, John D. Reid

Nebraska Department of Transportation: Research Reports

Portable concrete barrier (PCB) systems are often used to redirect errant vehicles through a combination of inertial resistance, lateral friction loads, and tensile loads developed from the mass and friction of the barrier segments. State departments of transportation (DOTs) and other end users may wish to utilize minimal length PCB installations to shield a hazard or work zone or limit the number of barriers required on the upstream and downstream ends to reduce overall system length. However, concerns with the performance of shorter PCB installations include increased lateral deflections and working widths and barrier pocketing. Additionally, no impact testing has …

Potential Benefits Of Combining Anomaly Detection With View Planning For Uav Infrastructure Modeling, R. Abraham Martin, Landen Blackburn, Joshua Pulsipher, Kevin W. Franke, John Hedengren

Faculty Publications

This paper presents a novel method for UAV-based 3D modeling of large infrastructure objects, such as pipelines, canals and levees, that combines anomaly detection with automatic on-board 3D view planning. The study begins by assuming that anomaly detections are possible and focuses on quantifying the potential benefits of the combined method and the view planning algorithm. A simulated canal environment is constructed, and several simulated anomalies are created and marked. The algorithm is used to plan inspection flights for the anomaly locations, and simulated images from the flights are rendered and processed to construct 3D models of the locations of …

Mechanical Engineering News, Georgia Southern University

Mechanical Engineering: News & Publications (2013-2023)

• Engineering Honor Society Induction Ceremonies

Developing And Implementing An Online Research Data Repository For Your University Or College Campus, Raymond J. Uzwyshyn

Digital Initiatives Symposium

Data-driven research is becoming increasingly important on university and college campuses. Most US federal and many international granting agencies mandatorily require that researchers applying for public grants possess a data management plan and make their research and data publically available through online access. This presentation overviews online research data repositories and implementation strategies for university and college campus libraries. The presentation pragmatically surveys this newer technology landscape and how organizations can begin to think about and implement an online data research repository. This session will survey the landscape but also makes use of practical example from Texas State University and …