Engineering Commons^™

A Multiscale Modeling Study Of Particle Size Effects On The Tissue Penetration Efficacy Of Drug-Delivery Nanoparticles, Mohammad Aminul Islam, Sutapa Barua, Dipak Barua

Chemical and Biochemical Engineering Faculty Research & Creative Works

Background: Particle size is a key parameter for drug-delivery nanoparticle design. It is believed that the size of a nanoparticle may have important effects on its ability to overcome the transport barriers in biological tissues. Nonetheless, such effects remain poorly understood. Using a multiscale model, this work investigates particle size effects on the tissue distribution and penetration efficacy of drug-delivery nanoparticles.

Results: We have developed a multiscale spatiotemporal model of nanoparticle transport in biological tissues. The model implements a time-adaptive Brownian Dynamics algorithm that links microscale particle-cell interactions and adhesion dynamics to tissue-scale particle dispersion and penetration. The model accounts …

Metabolomic Effects Of Ceo₂, Sio₂ And Cuo Metal Oxide Nanomaterials On Hepg2 Cells, Kirk T. Kitchin, Steve Stirdivant, Brian L. Robinette, Benjamin T. Castellon, Xinhua Liang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Background: To better assess potential hepatotoxicity of nanomaterials, human liver HepG2 cells were exposed for 3 days to five different CeO₂ (either 30 or 100 μg/ml), 3 SiO₂ based (30 μg/ml) or 1 CuO (3 μg/ml) nanomaterials with dry primary particle sizes ranging from 15 to 213 nm. Metabolomic assessment of exposed cells was then performed using four mass spectroscopy dependent platforms (LC and GC), finding 344 biochemicals.

Results: Four CeO₂, 1 SiO₂ and 1 CuO nanomaterials increased hepatocyte concentrations of many lipids, particularly free fatty acids and monoacylglycerols but only CuO elevated lysolipids and …

Classification Of Rest And Active Periods In Actigraphy Data Using Pca, Isaac W. Muns, Yogesh Lad, Ivan G. Guardiola, Matthew S. Thimgan

Engineering Management and Systems Engineering Faculty Research & Creative Works

In this paper we highlight a clustering algorithm for the purpose of identifying sleep and wake periods directly from actigraphy signals. The paper makes use of statistical Principal Component Analysis to identify periods of rest and activity. The aim of the proposed methodology is to develop a quick and efficient method to determine the sleep duration of an individual. In addition, a robust method that can identify sleep periods in the accelerometer data when duration, time of day varies by individual. A selected group of 10 individual's sensor data consisting of actigraphy from an accelerometer (3-axis), near body temperature, and …

Energy Consumption Modeling Of Stereolithography-Based Additive Manufacturing Toward Environmental Sustainability, Yiran Yang, Lin Li, Yayue Pan, Zeyi Sun

Engineering Management and Systems Engineering Faculty Research & Creative Works

Additive manufacturing (AM), also referred as three-dimensional printing or rapid prototyping, has been implemented in various areas as one of the most promising new manufacturing technologies in the past three decades. In addition to the growing public interest in developing AM into a potential mainstream manufacturing approach, increasing concerns on environmental sustainability, especially on energy consumption, have been presented. To date, research efforts have been dedicated to quantitatively measuring and analyzing the energy consumption of AM processes. Such efforts only covered partial types of AM processes and explored inadequate factors that might influence the energy consumption. In addition, energy consumption …

Reward/Penalty Design In Demand Response For Mitigating Overgeneration Considering The Benefits From Both Manufacturers And Utility Company, Md Monirul Islam, Zeyi Sun, Cihan H. Dagli

Engineering Management and Systems Engineering Faculty Research & Creative Works

The high penetration of renewable sources in electricity grid has led to significant economic, environmental, and societal benefits. However, one major side effect, overgeneration, due to the uncontrollable property of renewable sources has also emerged, which becomes one of the major challenges that impedes the further large-scale adoption of renewable technology. Electricity demand response is an effective tool that can balance the supply and demand of the electricity throughout the grid. In this paper, we focus on the design of reward/penalty mechanism for the demand response programs aiming to mitigate the overgeneration. The benefits for both manufacturers and utility companies …

A General Algorithm For Assessing Product Architecture Performance Considering Architecture Extension In Cyber Manufacturing, Md Monirul Islam, Zeyi Sun, Cihan H. Dagli

Engineering Management and Systems Engineering Faculty Research & Creative Works

In modern manufacturing, the product architecture design options are usually restricted to those that can be produced with 100% confidence using those proven technologies to satisfy the existing customer requirement. As a result, the inefficiencies of architecture design are considerable due to such limitations. This issue is of particular interests in cyber manufacturing when exploring the tradeoff between generality and feasibility in product design and manufacturing. It can be expected that the improvement and extension of the existing product architecture may be required to meet new customer requirement when new technologies become available. An effective system performance assessment algorithm is …

Analysis Of Autonomous Unmanned Aerial Systems Based On Operational Scenarios Using Value Modelling, Akash Vidyadharan, Robert Philpott Iii, Benjamin J. Kwasa, Christina L. Bloebaum

Engineering Management and Systems Engineering Faculty Research & Creative Works

In recent years, the use of UAS (Unmanned Aerial Systems) has moved beyond the realm of military operations and has made its way into the hands of consumers and commercial industries. Although the applications of UAS in commercial industries are virtually endless, there are many issues regarding their operations that need to be considered before these valuable pieces of equipment are allowed for widespread civil use. Currently, UAS operations in the public domain are guided and controlled by the FAA Part 107 rules after overwhelming public pressure caused by the earlier 333 exemption. In order to approach such larger issues, …

Indiana Local Roads - An Asset Management Guide For Cities, Towns And Counties, Applied Pavement Technology, Inc.

Indiana Local Technical Assistance Program (LTAP) Publications

This Guide is designed to serve as a resource to agencies adopting an asset management philosophy. It presents an asset management process that can be used by any local agency in Indiana. It also introduces common terminology and helpful hints to get you started. The Guide promotes a statewide approach to gather and analyze the information you need to develop an asset management plan. You can use this Guide to: learn more about what asset management is, identify the steps involved with implementing asset management, discover ways to use data to better communicate with elected officials, develop an effective asset …

From Paper To Digital Maintenance With Electronic Signature, Marcelo Backes, Fernando Miwa, Cesar Okajima, Ari Souza Jr., Daniel Tkacz

Graduate Student Works

This research paper reviewed the impact of the implementation of digital maintenance records replacing paper documents in the commercial aviation through gains in efficiency and cost reduction in airplane transitions. Throughout the lifecycle of a commercial airplane, repairs are incorporated, components are replaced and maintenance tasks are accomplished every day, each of those activities generate records that need to be kept and reconciled. Lessors have strict contract terms that require operators to keep all required maintenance documents stored and available so that asset value is maintained, this process is done today mostly with paper documents and is very costly and …

A New Way To Improve Logistics Efficiency And Aircraft-Onground Recovery, Katia Regina Goncalves, Erica Maria Dias Ferreira Cruz Grudzinski, Fabio Pinto, Carlos Alberto De Queiroz, Gilson Macedo Dos Santos

Graduate Student Works

The objective of this project was to bring more efficiency to logistics, improving time of Aircraft-on-Ground (AOG) recovery and developing possible saving for airlines operations. There proposed goal was to develop a system that would allow airlines to easily visualize an available space at the aircraft cargo bay on a desired flight and book its company materials (COMAT) on it, still respecting all appropriate regulation and the final availability of space.

This project was inspired by an existing system called MyIDTravel that allows jointed airline’s personnel to buy available tickets with low fares. The objective was to develop something similar …

Environmental & Economical Solution For São Paulo Congonhas Airport (Iata: Cgh, Icao: Sbsp), Adriana Larcerda, Daniel Fischer P. De Campos, Euler Sousa, Renato Achoa, Renato Carbonieri

Graduate Student Works

The final recommendations of this Capstone Project are to reduce the usage of the aircraft APU, implement noise abatement procedures on departures and landings and use the reverse thrust at idle within São Paulo Congonhas Airport (IATA: CGH, ICAO: SBSP) operations.

The predicted, and conservative outcomes resulting from these recommendations shall impact on reducing noise, carbon emissions and aviation fuel burn, by combining in-flight and on the ground measures.

The noise produced at the airport is estimated to reduce up to 50 dB at a given procedure, which shall improve health, environment and life quality of the population that live …

Security Baggage Process And On Time Performance At Guarulhos International Airport, Begara Diego, Adenil Oliveira, Davi Oliveira, Sabrina Santos, Ana Souza

Graduate Student Works

The study recommended starting the process of screening domestic passengers’ checked baggage at Guarulhos – São Paulo International Airport – for airlines efficiency and security improvement reasons. The aviation industry in Brazil is at risk. Domestic flights, which accounts for over 85% of the airport activity at Guarulhos International Airport, do not have a process in which checked baggage of the boarding passengers are duly screened. That risk is significant to personal welfare and business. This Capstone Project demonstrated that such an issue should be addressed. Not only is there a potential risk involved in not screening baggage of domestic …

Enabling Phased Array Signal Processing For Mobile Wifi Devices, Kun Qian, Chenshu Wu, Zheng Yang, Zimu Zhou, Xu Wang, Yunhao Liu

Research Collection School Of Computing and Information Systems

Modern mobile devices are equipped with multiple antennas, which brings various wireless sensing applications such as accurate localization, contactless human detection, and wireless human-device interaction. A key enabler for these applications is phased array signal processing, especially Angle of Arrival (AoA) estimation. However, accurate AoA estimation on commodity devices is non-trivial due to limited number of antennas and uncertain phase offsets. Previous works either rely on elaborate calibration or involve contrived human interactions. In this paper, we aim to enable practical AoA measurements on commodity off-the-shelf (COTS) mobile devices. The key insight is to involve users’ natural rotation to formulate …

Understanding Inactive Yet Available Assignees In Github, Jing Jiang, David Lo, Xinyu Ma, Fuli Feng, Li Zhang

Research Collection School Of Computing and Information Systems

Context In GitHub, an issue or a pull request can be assigned to a specific assignee who is responsible for working on this issue or pull request. Due to the principle of voluntary participation, available assignees may remain inactive in projects. If assignees ever participate in projects, they are active assignees; otherwise, they are inactive yet available assignees (inactive assignees for short). Objective Our objective in this paper is to provide a comprehensive analysis of inactive yet available assignees in GitHub. Method We collect 2,374,474 records of activities in 37 popular projects, and 797,756 records of activities in 687 projects …

Sourcevote: Fusing Multi-Valued Data Via Inter-Source Agreements, Xiu Susie Fang, Quan Z. Sheng, Xianzhi Wang, Mahmoud Barhamgi, Lina Yao, Anne H.H. Ngu

Research Collection School Of Computing and Information Systems

Data fusion is a fundamental research problem of identifyingtrue values of data items of interest from conflicting multi-sourceddata. Although considerable research efforts have been conducted on thistopic, existing approaches generally assume every data item has exactlyone true value, which fails to reflect the real world where data items withmultiple true values widely exist. In this paper, we propose a novel approach,SourceVote, to estimate value veracity for multi-valued data items.SourceVote models the endorsement relations among sources by quantifyingtheir two-sided inter-source agreements. In particular, two graphs areconstructed to model inter-source relations. Then two aspects of sourcereliability are derived from these graphs and …

Intent Recognition In Smart Living Through Deep Recurrent Neural Networks, Xiang Zhang, Lina Yao, Chaoran Huang, Quan Z. Sheng, Xianzhi Wang

Research Collection School Of Computing and Information Systems

Electroencephalography (EEG) signal based intent recognition has recently attracted much attention in both academia and industries, due to helping the elderly or motor-disabled people controlling smart devices to communicate with outer world. However, the utilization of EEG signals is challenged by low accuracy, arduous and time-consuming feature extraction. This paper proposes a 7-layer deep learning model to classify raw EEG signals with the aim of recognizing subjects’ intents, to avoid the time consumed in pre-processing and feature extraction. The hyper-parameters are selected by an Orthogonal Array experiment method for efficiency. Our model is applied to an open EEG dataset provided …

Animated Otto-Langen Atmospheric Engine, Keiran M. Hansen, Lance Hodgson, Rachel A. Jakob, Chris J. Splees

Mechanical Engineering

Based on an existing relationship between Dr. Owen and the Deutsches Museum, Otto-Mated was given the opportunity to collaborate with the two in a year-long senior design project. Otto-Mated was tasked with modeling and simulating the Otto-Langen Atmospheric Engine as a form of preservation and education. The model was created in SolidWorks and animated in Blender, effectively providing the museum with accurate and educational videos demonstrating the engine’s function. Within this document are the plans, decisions, and processes used to create our final product for Deutsches Museum.

Pull-Out Strength Of Fiberglass/Epoxy Composite Rebarfabricated On A Three-Dimensional Braiding Machine, Tarisai Machanzi

Theses and Dissertations

The objective of this research was to explore and demonstrate the production andperformance of fiber-reinforced polymer (FRP) rebar manufactured on a continuous threedimensionalbraiding machine for use as reinforcement in concrete structures. Differentconfigurations of fiberglass/epoxy composite cylindrical rebar rods were manufactured,embedded in concrete, and tested in axial tension to identify the relationships betweenmanufacturing parameters and tensile pull-out strength of the rebar. The strength of the bondbetween concrete and FRP rebar was investigated using the pull-out test detailed by ACI 440.3R-12. The rebar was a No. 4 size and produced by combining multiple tows of fiberglass/epoxyprepreg to form the core of cylindrical …

Experimental Investigations Of Techniques To Enhance The Cooling Rate Of Hot Fluids By Utilizing Gallium As A Heat Sink Material, Abdallah M. S. Ghazal

Mechanical Engineering Theses

No abstract provided.

Alternative Mission Concepts For The Exploration Of Outer Planets Using Small Satellite Swarms, Andrew Gene Blocher

Master's Theses

Interplanetary space exploration has thus far consisted of single, expensive spacecraft missions. Mission costs are particularly high on missions to the outer planets and while invaluable, finite budgets limit our ability to perform extensive and frequent investigations of the planets. Planetary systems such as Jupiter and Saturn provide extremely complex exploration environments with numerous targets of interest. Exploring these targets in addition to the main planet requires multiple fly-bys and long mission timelines. In LEO, CubeSats have changed the exploration paradigm, offering a fast and low cost alternative to traditional space vehicles. This new mission development philosophy has the potential …

Twin-Wing Design Options Used For Unmanned Aerial Vehicles To Achieve High Altitudes At Low Speeds, Ian R. Mcandrew, Elena Vishnevskaya, Andrew Carruthers

Publications

The paper addresses the aerodynamic performance of twin‐wing aircraft (biplanes) that are remotely piloted. While twin wing aircraft are acknowledged as to having greater maneuverability than monoplanes, they have inherent disadvantages based on the set position of the upper wing to meet piloting needs which induces significant levels of drag from the struts that link the upper and lower wings together. In this research, the aerodynamics of the wing position in relationship to the lower wing are analyzed with Computational Fluid Mechanics/Dynamics and simulation models. It will show that modern material can eliminate the strut drag and allow for greater …

Developing New Classes Of Thick-Origami-Based Mechanisms: Conceal-And-Reveal Motion And Folding Printed Circuit Boards, Bryce Parker De Figueiredo

Theses and Dissertations

Origami-adapted mechanisms form the basis of an increasing number of engineered systems. As most of these systems require the use of non-paper materials, various methods for accommodating thickness have been developed. These methods have opened new avenues for origami-based design. This work introduces approaches for the design of two new classes of thick-origami systems and demonstrates the approaches in hardware. One type of system, called "conceal-and-reveal,'' is introduced, and a method of designing these mechanisms is developed. Techniques are also developed for designing folding printed circuit boards which are fabricated from a single sheet of material. This enables areas of …

Design, Fabrication, And Characterization Of Hg2 Sensor Based On Graphite Oxide And Metallic Nanoclusters, Abdul Rehman Said Rehman

Electrical Engineering Theses

It has been previously demonstrated that improving the detection of mercury (Hg²⁺) in water is of significant importance since the Hg²⁺ has detrimental effects on human health and could lead to toxicity, especially in utero. One way this could be achieved is through the design of highly sensitive and selective sensors for Hg²⁺ contents in water.

In this work, it is hypothesized that sensors with silver nanoclusters enhance the sensitivity of the fabricated sensor and possess the highest selectivity to the Hg²⁺ detected in this study. In order to verify this hypothesis, sensors with silver …

Modelling And Simulation Of Hydrogen Production Via Membrane Reactor, Aya Abdel-Hamid Smail Mourad

Chemical and Petroleum Engineering Theses

A membrane reactor is a promising device to produce pure hydrogen and enrich CO₂ from syngas. A simulation study of a double tubular catalytic membrane reactor for the water-gas shift reaction (WGS) under steady-state operation is presented in this work. The membrane consists of a dense Pd layer (selective to H₂) deposited on a porous glass cylinder support. The reaction side was filled with a commercial iron-chromium oxide catalyst, designed as Girdler G-3. The mass of the catalyst was 12.1 g and the height of the catalyst bed was 8 cm. The WGS model was carried out …

Investigation Of The Effect Of Supercritical Carbon Dioxide Extraction On The Adsorption Capacity Of Date Pits, Haliemeh Imad Sweidan

Chemical and Petroleum Engineering Theses

This thesis aims to develop and investigate an innovative use of date pits, a common and abundant agricultural waste in the UAE. It is suggested that date pits may be used to produce date pit oil, and the powder residue from this extraction process may be used as a low cost adsorbent for removal of lead from water. This thesis aims to investigate the effects of the parameters pressure, temperature, and particle size on the extraction yield when using supercritical carbon dioxide (SC-CO₂) to extract oil from date pit powder. This oil is a valuable component which has many applications …

Numerical Modeling To Evaluate The Performance Of Slow-Release Candles For Groundwater Remediation, Chuyang Liu

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Slow-release candles (SRC) have been developed as a cost-effective technology to treat groundwater contaminants by passively delivering oxidants into the subsurface over a long time. In this thesis, a numerical model has been developed to simulate oxidant release kinetics, transport, and reaction in a field scale. Parameters of the model were obtained from a field site with SRC installed. Modeling results showed that the radius of influence of oxidants was influenced by the relative contribution of reaction and solute transport, and the limited lateral spreading could be an issue to restrict the application of SRC.

Enhanced aeration could increase or …

Calibrating And Evaluating Dynamic Rule-Based Transit-Signal-Priority Control Systems In Urban Traffic Networks, Md Didarul Alam

Civil and Environmental Engineering Dissertations

Setting the traffic controller parameters to perform effectively in real-time is a challenging task, and it entails setting several parameters to best suit some predicted traffic conditions. This study presents the framework and method that entail the application of the Response Surface Methodology (RSM) to calibrate the parameters of any control system incorporating advanced traffic management strategies (e.g., the complex integrated traffic control system developed by Ahmed and Hawas). The integrated system is a rule-based heuristic controller that reacts to specific triggering conditions, such as identification of priority transit vehicle, downstream signal congestion, and incidents by penalizing the predefined objective …

How Transportation Network Companies Could Replace Public Transportation In The United States, Matthew L. Kessler

USF Tampa Graduate Theses and Dissertations

The quantity of cell phone applications or mobile apps have seen an upsurge at an exponential rate in under a decade. Many have been created for a variety of industries, including transportation. The advent and subsequent commercialized implementation of near-instant transport by a middleman-type of app is now known as a Transportation Network Company or TNC. Examples of the more renowned TNCs are Uber, Lyft and Sidecar.

In recent years, TNCs have cultivated a tremendous following, to the degree of taxicab desertion. Moreover, the massive success of TNCs led to expansion of its capacities into public transportation.

The TNC’s expeditious …

A Case Study Of Instructional Methods Used For Private Pilot Certification At Utah Valley University Flight School, Michael Robert Graham

Theses and Dissertations

In this case study, researchers investigated the instructional methods used to train private pilot students at Utah Valley University. Traditional one-on-one individualized learning methods were replaced with cooperative learning methods. Descriptive statistics were used to determine the effectiveness and efficiency of the cooperative learning methods used. Reduced training time, less repeated lessons and a reduced number of flight hours showed that cooperative learning methods were more efficient and a more effective way to train private pilot students at Utah Valley University.

The State Of Bim-Based Quantity Take-Off Implementation Among Commercial General Contractors, Morgan Christian Tagg

Theses and Dissertations

Building Information Modeling (BIM) plays an important role in today's construction industry. Models are tools that help stakeholders communicate, visualize building geometry, perform trade coordination and clash detection among others. A less popular aspect of BIM that shows high potential is the quantity take-off (QTO) feature. Yet, its implementation among commercial general contractors (GC) has not received as much attention. The purpose of this study was to identify how the BIM QTO features were being implemented among commercial general contractors, what challenges they faced and how they worked to overcome those challenges. Through a three-step process including semi structured interviews …