Engineering Commons^™

Feasibility Of Using An Equilibrium Point Strategy To Control Reaching Movements Of Paralyzed Arms With Functional Electrical Stimulation, Matthew Huffman

ETD Archive

Functional electrical stimulation (FES) is a technology capable of improving the quality of life for those with the loss of limb movement related to spinal cord injuries. Individuals with high-level tetraplegia, in particular, have lost all movement capabilities below the neck. FES has shown promise in bypassing spinal cord damage by sending electrical impulses directly to a nerve or muscle to trigger a desired function. Despite advancements in FES, full-arm reaching motions have not been achieved, leaving patients unable to perform fundamental tasks such as eating and grooming. To overcome the inability in current FES models to achieve multi-joint coordination, …

A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr.

ETD Archive

Star polymers are a class of branched polymers comprised of several polymer chains extending from a central point. Star polymers have applications in biopharmaceuticals where they have been proposed to be suitable drug delivery vehicles. Star polymers have traditionally been synthesized through chemical synthesis with added functionality provided by grafting on the arms. This complex synthesis can be simplified by using a biosynthetic approach which enables precise control of molecular weight and composition. This approach is demonstrated using star polymers with arms composed of a temperature responsive protein-based polymer termed elastin-like polypeptide (ELP). Star polymers are characterized based on the …

Real-Time Assessment And Visual Feedback For Patient Rehabilitation Using Inertial Sensors, Deepa Adinarayanan

ETD Archive

Rehabilitation exercises needs have been continuously increasing and have been projected to increase in future as well based on its demand for aging population, recovering from surgery, injury and illness and the living and working lifestyle of the people. This research aims to tackle one of the most critical issues faced by the exercise administers-Adherence or Non-Adherence to Home Exercise problems especially has been a significant issue resulting in extensive research on the psychological analysis of people involved. In this research, a solution is provided to increase the adherence of such programs through an automated real-time assessment with constant visual …

Influence Of Natural Convection During Dendritic Array Growth Of Metal Alloys (Gradient Freeze Directional Solidification), Suyog N. Mahajan

ETD Archive

Purpose of this study was to examine the microstructural evolution of primary dendrites during Gradient Freeze Directional Solidification process in cylindrical Pb-5.8% Sb alloy samples to generate the ground- based research data to support a future microgravity experiment on the Space Station in a convection free environment. Pb-5.8Sb was selected for this study because of its ease of processing and availability of physical property data which will be required for predicting the dendrite morphology parameters, such as, primary dendrite spacing and dendrite trunk diameter. This alloy is also susceptible to thermosolutal convection caused by density inversion of the met in …

Effect Of History On The Binary Adsorption Equilibria Of Aluminium Terephthalate (Mil-53(Al)), Ufuoma Israel Kara

ETD Archive

Metal organic frameworks (MOFs) are highly porous solids with potential applications in a wide range of fields including gas separations and catalysis. Most of porous solids used in these applications such as zeolites and activated carbon usually have rigid structures. In contrast, a number of metal-organic frameworks (MOFs) exhibit structural transformation in response to external stimuli. Such materials show promise for applications such as sensors, actuators and adsorptive separations. Several thermodynamic formalisms were proposed in literature to explain this phenomenon, often known as gate-opening or “breathing” of the MOF material. In this study, the adsorptive behavior of MIL-53(Al), a MOF …

Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag

ETD Archive

Kidney cyst expansion, stagnant fluid accumulation, and insufficient vascular supply can result in localized chronic ischemia-hypoxia in kidney cysts, as well as in normal renal epithelia adjacent to a cyst. We hypothesize that in normal epithelia near a cyst, the stabilization of Hypoxia Inducible Factor 1a (HIF1a), a major regulator of cellular response to hypoxia, can cause altered paracellular and transcellular transport, transforming a normal absorptive phenotype to a secretory and paracellularly leaky phenotype, leading to cyst expansion. Using 100 µmol/L cobalt chloride (CoCl2), HIF1a was stabilized in cellular nucleus of a mouse cortical collecting duct cell line (mCCD 1296 …

Continuous Human Activity Tracking Over A Large Area With Multiple Kinect Sensors, Akshat C. Hans

ETD Archive

In recent years, researchers had been inquisitive about the use of technology to enhance the healthcare and wellness of patients with dementia. Dementia symptoms are associated with the decline in thinking skills and memory severe enough to reduce a person’s ability to pay attention and perform daily activities. Progression of dementia can be assessed by monitoring the daily activities of the patients. This thesis encompasses continuous localization and behavioral analysis of patient’s motion pattern over a wide area indoor living space using multiple calibrated Kinect sensors connected over the network. The skeleton data from all the sensor is transferred to …

School Logo Cleveland State University Logo Title Evolutionary Optimization For Safe Navigation Of An Autonomous Robot In Cluttered Dynamic Unknown Environments, Arash Roshanineshat

ETD Archive

We present a path planning approach based on probabilistic methods for a robot to navigate in a cluttered, dynamic, unknown environment. There are dynamic obstacles moving around and static obstacles located in the map. The robot does not have any prior information about them but should be able to navigate through the map beginning from a known starting point and safely ending at a known target point. The only information the robot has is the location of the starting point and the target point and it uses sensory information to collect information about its surroundings. Our method is compared to …

Determination Of Growth Kinetics, Yield Coefficients And Biodiesel Properties For The Green Microalgae Scenedesmus Dimorphus In Freshwater And Saline Medias, Morgan L. Cohara

ETD Archive

Of the many alternative resources capable of generating biofuel, microalgal oil serves as a promising feedstock. Unfortunately, biodiesel production from microalgae is currently hindered by high operational costs. One primary causes for these high costs is the large quantity of freshwater required for cultivation. This experiment was designed to assess the feasibility of growing the green, freshwater microalgae Scenedesmus dimorphus in an increasingly saline environment. Both average yield coefficients and growth rates were monitored with increasing salt concentration. Determination of average yield coefficients allows for process scale-up and the optimization of production costs by minimizing raw material waste. Salinity was …

Predictive Simulations Of Gait And Their Application In Prosthesis Design, Anne D. Koelewijin

ETD Archive

Predictive simulations predict human gait by solving a trajectory optimization problem by minimizing energy expenditure. These simulations could predict the effect of a prosthesis on gait before its use. This dissertation has four aims, to show the application of predictive simulations in prosthesis design and to improve the quality of predictive simulations. Aim 1 was to explain joint moment asymmetry in the knee and hip in gait of persons with a transtibial amputation (TTA gait). Predictive simulations showed that an asymmetric gait required less effort. However, a small effort increase yielded a gait with increased joint moment symmetry and reduced …

High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang

ETD Archive

The U.S Environmental Protection Agency (EPA) launched the Transform Tox Testing Challenge in 2016 with the goal of developing practical methods that can be integrated into conventional high-throughput screening (HTS) assays to better predict the toxicity of parent compounds and their metabolites in vivo. In response to this need and to retrofit existing HTS assays for assessing metabolism-induced toxicity of compounds, we have developed a 384-pillar plate that is complementary to traditional 384-well plates and ideally suited for culturing human cells in three dimensions (3D) at a microscale. Briefly, human embryonic kidney (HEK) 293 cells in a mixture of alginate …

Color Removal From Combined Dye And Fruit Nectar Wastewater Using Adsorption And Microfiltration, Oluwatobiloba A. Akinwande

ETD Archive

Pollution of the waterways is a great challenge of the 21st century. Textile effluents contain compounds which have the capacity to cause more harm when ingested. There are many dye removal technologies like coagulation, photo oxidation which help to remove color from dye wastewater. The use of adsorption to remove color from dye wastewater has been used for many centuries. Activated carbon can efficiently remove color from dye wastewater but it is very expensive and so different researches have been conducted to get the adsorption capacity of different forms of adsorbents. These adsorbents can be gotten from agricultural waste, biomass, …

Factors Affecting Minimum Dissolved Oxygen Concentration In Streams, Chistopher Robert Huhnke

ETD Archive

Modeling water quality has been shown to be a useful tool in strategizing water quality management. Dissolved oxygen (DO) has one of the largest impacts on water quality compared to other parameters. The purpose of the dissertation research is to generate a regression equation model, using the US EPA QUAL2K model as the base, to determine different factors affecting minimum dissolved oxygen concentrations in streams, to determine the critical distance for the minimum dissolved oxygen concentration, and the magnitude of impact of each parameter. Based on regression analysis, the factors affecting minimum DO in river water are effluent biochemical oxygen …

A Transformative Process Control Solution, Simone Castanho Nobrega De Almedia Soares

ETD Archive

Knowing that a technology invented almost hundred years ago (PID controller) is still dominating industrial process control, a historical review was done to understand how the control field evolved. Model dependency and high level of mathematics appear as the main reasons that prevent other technologies from penetrating the engineering practice. A relatively novel methodology introduced by J. Han in 1998 called Active Disturbance Rejection Control (ADRC) came with characteristics that matches process control needs and restrictions on model dependency. This study will present a transformative solution for process control based on that. The control algorithm is designed and discretized for …

Adsorption And Microfiltration Processes To Treat Dye And Coffee Wastewater., Abhiram Siva Prasad Pamula

ETD Archive

Wastewater from coffee processing industry creates high biological and chemical oxygen demand in the surface water. In addition to coffee wastewater from coffee industry, dyes from textile industry enter surface water affecting water quality in terms of transmissivity of light. Adsorption is an economical wastewater treatment process to remove color from dye and coffee wastewater. In the current thesis, adsorption using low-cost adsorbents like peanut hull and onion peel are used to treat combined dye and coffee wastewater. Three representative dyes including acid black 48, disperse yellow 3, crystal violet certified with processed coffee is used in preparing batch adsorption …

Drughelp.Care – A Web Application For The Discovery Of Drug Addiction Treatment Facilities, Sachin Hiriyanna

ETD Archive

One of the current and biggest problems in the system of emergency care for the drug overdose epidemic, is the failure of information delivery on nearby treatment facilities. Even though some initiatives on the internet tried to solve this issue, they either failed in delivering the information or in providing ease of usability. This thesis research aims to develop a web application which, 1. Delivers a highly accurate, easy-to-understand and targeted information in a timely manner for drug abusers and their well-wishers. 2. Provides an eco-system for the treatment facilities with an easy-to-use backend to constantly update their complex information …

Designing Novel Grooved Pallets For Industrial Application, Mirza Mohammed Abdullah Baig

ETD Archive

The purpose of this study was to model an improved pallet design which could overcome the drawbacks and failures of the pallets available in the market today. The new modeled pallets were designed to improve the capacity of the individual pallets and thereby increase the efficiency of the material handling process. The new modeled pallets were also designed with the aim to replace the racking system used for storage in the warehouse industry. The study was performed using two finite element analysis software, SOLIDWORKS and ANSYS, as analysis tools to study the behavior of the design under various real world …

An Anisotropic Constitutive Model For Nuclear Grade Graphite, James Christopher

ETD Archive

Graphite material is used extensively in nuclear reactors however the material has a limited strain range for elastic behavior. This provides the motivation to derive a constitutive model that captures the inelastic deformations exhibited by this material. This dissertation first presents details of an isotropic constitutive model derived using continuum principles of engineering mechanics that accounts for different inelastic behavior in tension and compression. An inelastic dissipation function was developed using an integrity basis proposed by Green and Mkrtichian (1977) for the isotropic version of the model. This isotropic model was then extended to capture anisotropic stress-strain behavior using directional …

G-Code Modeling For 3d Printer Quality Assessment, Tyler Welander, Ronald Marsh, Md Nurul Amin

Computer Science Faculty Publications

The Department of Computer Science at the University of North Dakota (UND) has been evaluating optical/imaging methods for measuring the quality of 3D printed parts. In particular, we are interested in optical/imaging methods that can detect and measure such quality issues as layer shifting, layer separation and splitting, overheating, dimensional accuracy, and infill errors. This paper describes our work towards the analysis of infill errors as the quality of the infill does impact the structural integrity of the part being made. Externally, a part may look acceptable, but if the infill is faulty the part may be structurally unsound. Furthermore, …

Pedagogical Benefits From An Exercise In Reverse Engineering For An Aviation Software Systems, Emanuel S. Grant, Pann Ajjimaporn

Computer Science Faculty Publications

Since the Y2K crisis, reverse engineering has become a major area of work in industrial software application development, but lacks emphasis in US academia. This issue is exemplified by the high demand for software systems in new and expanding software application areas, which has resulted in systems being implemented before the requirements and design phases have been completed. Towards the maintenance of such systems, it is necessary to conducted reverse engineering for the derivation of software documentation for requirements and high-level and low-level design. When this scenario exists in the domain of safety-critical system, particularly in the aviation industry, reverse …

An Integrated Microstructural-Nanomechanical-Chemical Approach To Examine Material-Specific Characteristics Of Cementitious Interphase Regions, Mahdieh Khedmati, Yong-Rak Kim, Joseph A. Turner, Hani Alanazi, Charles Nguyen

Department of Mechanical and Materials Engineering: Faculty Publications

Effective properties and structural performance of cementitious mixtures are substantially governed by the quality of the interphase region because it acts as a bridge transferring forces between aggregates and a binding matrix and is generally susceptible to damage. As alternative binding agents like alkali-activated precursors have obtained substantial attention in recent years, there is a growing need for fundamental knowledge to uncover interphase formation mechanisms. In this paper, two different types of binding materials, i.e., fly ash-based geopolymer and ordinary portland cement, were mixed with limestone aggregate to examine and compare the microstructures and nanomechanical properties of interphase region. To …

Methods, Systems, And Devices For Surgical Access And Procedures, Shane M. Farritor, Mark Rentschler, Amy Lehman, Stephen R. Platt, Jeff Hawks

Department of Mechanical and Materials Engineering: Faculty Publications

The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Certain embodiments include various actuation system embodiments, including fluid actuation systems, drive train actuation systems, and motorless actuation systems. Additional embodiments include a reversibly lockable tube that can provide access for a medical device to a patient's cavity and further provides a reversible rigidity or stability during operation of the device. Further embodiments include various operational components for medical devices, including medical device arm mechanisms that have both axial and rotational movement while maintaining a relatively compact …

Excess Charge-Carrier Induced Instability Of Hybrid Perovskites, Yuze Lin, Bo Chen, Yanjun Fang, Jingjing Zhao, Chunxiong Bao, Zhenhua Yu, Yehao Deng, Peter N. Rudd, Yanfa Yan, Yongbo Yuan, Jinsong Huang

Department of Mechanical and Materials Engineering: Faculty Publications

Identifying the origin of intrinsic instability for organic–inorganic halide perovskites (OIHPs) is crucial for their application in electronic devices, including solar cells, photodetectors, radiation detectors, and light-emitting diodes, as their efficiencies or sensitivities have already been demonstrated to be competitive with commercial available devices. Here we show that free charges in OIHPs, whether generated by incident light or by current-injection from electrodes, can reduce their stability, while efficient charge extraction effectively stabilizes the perovskite materials. The excess of both holes and electrons reduce the activation energy for ion migration within OIHPs, accelerating the degradation of OIHPs, while the excess holes …

An Agile Quality Management System For Laboratory Developed Tests, Rita D'Angelo

Wayne State University Dissertations

ABSTRACT

AN AGILE QUALITY MANAGEMENT SYSTEM FOR LABORATORY DEVELOPED TESTS

By

RITA D’ANGELO

MAY 2017

Advisor: Dr. Ratna Babu Chinnan

Major: Industrial & Systems Engineering

Degree: Doctor of Philosophy Statement of the Problem: We explore the 2014 draft guidance by the FDA entitled Framework for Regulatory Oversight of Laboratory Developed Tests (LDT) extended from the medical device industry and discuss how these requirements may be applicable to laboratory medicine. We introduce terms, definitions and provide a call for action for leaders to prepare for the potential adherence to regulatory requirements and explore if compliance was achievable in a laboratory environment …

Modular Product Architecture’S Decisions Support For Remanufacturing-Product Service System Synergy, Johnson Adebayo Fadeyi

Wayne State University Dissertations

Remanufacturing is identified as the most viable product end-of-life (EOL) management strategy. However, about 80% of manufactured products currently end up as wastes. Besides other benefits, the product service system (PSS) could curtail the main bottlenecks to remanufacturing namely quantity, quality, recovery time of used product, and negative perception of remanufactured products. Therefore, the integration of PSS and remanufacturing has been increasingly recommended as an enhanced product offering. However, an integration that is informed by mathematical analysis is missing. Meanwhile, the variables that bolster the performance of PSS and remanufacturing are substantially influenced by product development (PD) decisions. Among the …

Maximum Recovery Of Mechanical Energy Through Work Integration: A Work Exchange Network Synthesis Approach, Aida Amini Rankouhi

Wayne State University Dissertations

Sustainable development has become a key concern in industries, largely due to natural resource depletion, global competition, and environmental pressure. Despite the efforts for sustainability improvement, still over a half of energy consumption is wasted in manufacturing sectors, where the chemical industry is responsible for an energy efficiency lower than it should be. Many attempts have been made to recover the thermal energy using heat integration techniques. Although process work is more expensive than process heat, no efficient solution has been studied to recover mechanical energy yet. In chemical plants, many process streams need to be pressurized or depressurized in …

Data-Driven Modeling For Decision Support Systems And Treatment Management In Personalized Healthcare, Milad Zafar Nezhad

Wayne State University Dissertations

Massive amount of electronic medical records (EMRs) accumulating from patients and populations motivates clinicians and data scientists to collaborate for the advanced analytics to create knowledge that is essential to address the extensive personalized insights needed for patients, clinicians, providers, scientists, and health policy makers. Learning from large and complicated data is using extensively in marketing and commercial enterprises to generate personalized recommendations. Recently the medical research community focuses to take the benefits of big data analytic approaches and moves to personalized (precision) medicine. So, it is a significant period in healthcare and medicine for transferring to a new paradigm. …

Analysis Of Micromixers To Minimize Scaling Effects On Reverse Osmosis Membranes, Jeremy Walker

Wayne State University Dissertations

ABSTRACT

ANALYSIS OF MICROMIXERS TO MINIMIZE SCALING EFFECTS ON REVERSE OSMOSIS MEMBRANES

by

Jeremy Walker

December 2018

Advisor: Dr. Shawn McElmurry

Major: Civil Engineering

Degree: Doctor of Philosophy

Structural elements, typically mesh spacers, are required between membrane leaves in spiral

wound elements to ensure flow through reverse osmosis (RO) modules. The standard diamond-shaped

mesh spacer results in non-ideal hydrodynamics that can lead to fouling, which ultimately reduces the

flux of water through the membrane and the operational life of the unit. Additionally, traditional mesh

feed spacers do not allow for reverse flow cleaning due to obstructed flow paths and, once …

Using Regular Languages To Explore The Representational Capacity Of Recurrent Neural Architectures, Abhijit Mahalunkar, John D. Kelleher

Conference papers

The presence of Long Distance Dependencies (LDDs) in sequential data poses significant challenges for computational models. Various recurrent neural architectures have been designed to mitigate this issue. In order to test these state-of-the-art architectures, there is growing need for rich benchmarking datasets. However, one of the drawbacks of existing datasets is the lack of experimental control with regards to the presence and/or degree of LDDs. This lack of control limits the analysis of model performance in relation to the specific challenge posed by LDDs. One way to address this is to use synthetic data having the properties of subregular languages. …

Hierarchical Hybrid Architectures For Robust And Reusable Nano-Devices, Sharmila M. Mukhopadhyay

Mechanical and Materials Engineering Faculty Publications

No abstract provided.