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Articles 79411 - 79440 of 196433
Full-Text Articles in Engineering
Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth
Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth
ETD Archive
Hepatocellular carcinoma (HCC) is an invasive and aggressive cancer of the liver that arises due to chronic cirrhosis. Research into understanding HCC has focused on two-dimensional (2D) and three-dimensional (3D) technologies to simulate the liver microenvironment and use animal models to model how HCC affects the rest of the body. 3D hydrogel models are desired because they can mimic the transport behavior observed in vivo by structurally mimicking the extracellular matrix (ECM) without the ethical concerns of animal models. However, hydrogels can be toxic to cells and require optimal procedures for appropriate handling. In this study, we created 3D models …
Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros
Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros
ETD Archive
In metallurgy, Titanium has been a staple for biomedical purposes. Its low toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between Titanium alloys (116 GPa) and human bone (40-60 GPa) contribute to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as Vanadium and Aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimers and Parkinsons. Alternative metals known to be less toxic are being explored as replacements for alloying elements in Titanium alloys. …
Implementation Of A Reverse Staggered-Herringbone Microfluidic Mixer For High-Throughput Polymeric Nanoparticles Synthesis, Alexa Roberts
Implementation Of A Reverse Staggered-Herringbone Microfluidic Mixer For High-Throughput Polymeric Nanoparticles Synthesis, Alexa Roberts
Undergraduate Research Posters 2018
The goal of this research is to implement and optimize the operating conditions of a microfluidic mixer to synthesize polymeric nanoparticles (NPs) in a high-throughput fashion. Using a reverse staggered-herringbone microfluidic mixer that we recently designed, the effects of experimental conditions such as flowrate and reactant composition on NP characteristics were investigated and optimized. The device design allowed for physical contact between two streams of fluids – one containing poly(lactic-co-glycolic acid; PLGA) in acetonitrile and the other deionized water, to allow for efficient mixing and NP precipitation to occur. The resulting NPs were characterized using dynamic light scattering (DLS) and …
Prediction Of Metabolism-Induced Neurotoxicity On A 384pillarplate, Rushabh Patel, Pranav Joshi, Soo-Yeon Kang, Stephen Hong, Parnian Bigdelou
Prediction Of Metabolism-Induced Neurotoxicity On A 384pillarplate, Rushabh Patel, Pranav Joshi, Soo-Yeon Kang, Stephen Hong, Parnian Bigdelou
Undergraduate Research Posters 2018
Metabolism of compounds including neurotoxins primarily occurs in the liver by a variety of drug-metabolizing enzymes (DMEs) followed by a series of downstream responses. Unmodified (or parent) neurotoxins are transported into human hepatocytes through several influx transporters or via passive diffusion and undergo Phase I and Phase II biotransformation by DMEs before they are cleared. Neurotoxins and their metabolites generated from human hepatocytes could potentially lead to the toxic effects on neural stem cells (NSCs) as the reactive metabolites have potential for producing reactive oxygen species (ROS), which can lead to irreversible oxidative damage to NSCs via lipid peroxidation, DNA, …
Dendrite Morphology Of Pb-5.8 Sb Alloy: Gradient Freeze Ds With Cross-Section Area Change, Michael Shannon
Dendrite Morphology Of Pb-5.8 Sb Alloy: Gradient Freeze Ds With Cross-Section Area Change, Michael Shannon
Undergraduate Research Posters 2018
Directional solidification (DS) is the process of solidifying a metal alloy from one end to another resulting in aligned primary dendrites which are branched tree like features. Alignment of primary dendrites along [100] direction and their uniformity and distribution along the DS length determines the mechanical properties. These properties are especially important for single crystal turbine blade applications in modern gas turbine engines. Convection during solidification plays an important role in formation of detrimental defects, such as, misaligned grains, non-uniformity of dendrites and composition inhomogeneity. In this study the microstructural evolution during “Gradient Freeze DS process”, involving an abrupt cross-section …
Bespoke Mobile Application Development: Facilitating Transition Of Foundation Students To Higher Education, Nevan Bermingham, Mark Prendergast
Bespoke Mobile Application Development: Facilitating Transition Of Foundation Students To Higher Education, Nevan Bermingham, Mark Prendergast
Books/Book Chapters
Smartphone usage by students has increased rapidly over the last number of years, and it is expected that the utilisation of mobile applications in educational environments will continue to increase. This chapter focuses on a bespoke mobile application which aims to facilitate the transition of Foundation students to Higher Education in an Irish setting. Foundation students comprise of Access and International Students participating on pre-degree foundation courses. These students experience a major life change in making this transition and it is important that efforts are made to ensure a successful adjustment experience. Research suggests that mobile technologies can play a …
Where There Is No Engineer Chapter 06, Liam Mccarton, Sean O'Hogain
Where There Is No Engineer Chapter 06, Liam Mccarton, Sean O'Hogain
Books/Book Chapters
This chapter summarises the learning outcomes from the design program.
An Yb3+-Ho3+ Codoped Glass Microsphere Laser In The 2.0Μm Wavelength Regions, Angzhen Li, Jibo Yu, Meng Zhang, Xiaosong Lu, Jiquan Zhang, Elfed Lewis, Gerald Farrell, Pengfei Wang
An Yb3+-Ho3+ Codoped Glass Microsphere Laser In The 2.0Μm Wavelength Regions, Angzhen Li, Jibo Yu, Meng Zhang, Xiaosong Lu, Jiquan Zhang, Elfed Lewis, Gerald Farrell, Pengfei Wang
Articles
In this letter, an Yb 3+ -Ho 3+ codoped sol-gel silica microsphere lasing at around 2.0 μm is reported. The gain microsphere is fabricated by overlaying the 1.0 mol% Yb 3+ -0.2 mol% Ho 3+ codoped sol-gel solution on the surface of a pure silica microsphere and is then heated using a CO 2 laser. Using a traditional fiber taper-microsphere coupling method, we observe the single- and multi-mode microsphere laser outputs around 2.0 μm using a 980 nm laser diode as a pump source, with a low threshold pumping power of 14.7 mW. The ability to fabricate sol-gel codoped silica …
A High-Temperature Humidity Sensor Based On A Singlemode-Side Polished Multimode-Singlemode Fiber Structure, Xianfan Wang, Ke Tian, Libo Yuan, Elfed Lewis, Gerald Farrell, Pengfei Wang
A High-Temperature Humidity Sensor Based On A Singlemode-Side Polished Multimode-Singlemode Fiber Structure, Xianfan Wang, Ke Tian, Libo Yuan, Elfed Lewis, Gerald Farrell, Pengfei Wang
Articles
A relative humidity (RH) sensor based on a simple singlemode-side polished multimode-singlemode (SSPMS) fiber hybrid structure is investigated, which is capable of working over a relatively high-temperature range, at which many RH sensors based on moisture sensitive material coatings cannot operate. The beam propagation method is used to analyze the light transmission characteristics within the side polished multimode fiber (SPMMF) structure. Experimental results show that the SPMMF surface roughness has a significant influence on the sensor's humidity sensing performance, as a result of the adsorption and desorption of water molecules along the side polished surface. A higher surface roughness results …
A High Sensitivity Temperature Sensor Based On Balloon-Shaped Bent Smf Structure With Its Original Polymer Coating, Ke Tian, Gerald Farrell, Elfed Lewis, Xianfan Wang, Haidong Liang, Pengfei Wang
A High Sensitivity Temperature Sensor Based On Balloon-Shaped Bent Smf Structure With Its Original Polymer Coating, Ke Tian, Gerald Farrell, Elfed Lewis, Xianfan Wang, Haidong Liang, Pengfei Wang
Articles
A high sensitivity optical fibre temperature sensor is demonstrated based on a balloon-shaped bent single-mode (BSBS) fibre structure where the fibre retains its original protective polymer coating. The BSBS fibre structure can be simply realized by bending a coated straight singlemode fibre into the balloon shape using a section of silica capillary tube. By adjusting the bending radius of the balloon-shaped fibre section, a modal interferometer between the core mode and the coating mode can be effectively implemented at a suitable bending radius. Considering the intrinsically high thermo-optical coefficient and thermal expansion coefficient of the polymer coating, the BSBS fibre …
Position Paper: Collaborative Research, Caitriona Quinn
Position Paper: Collaborative Research, Caitriona Quinn
Other resources
This position paper is written on the topic of collaborative learning and how it might improve the ability of students, specifically third level students, to achieve learning outcomes within the construct of a project-based module. It is the author’s position that this statement is true. The topic is be discussed in relation to two specific aspects within the topic, student motivation and achievement of learning outcomes. Collaborative learning is based in social constructivism learning theory, which says that learning is co-created in a social context by learners. This is in contrast to the transmission method of learning, typified by traditional-style …
Validation Of Low-Cost Wireless Eeg System For Measuring Event-Related Potentials, Yongxiang Wang, Zhengwei Wang, William Clifford, Charles Markham, Tomas Ward, Catherine Deegan
Validation Of Low-Cost Wireless Eeg System For Measuring Event-Related Potentials, Yongxiang Wang, Zhengwei Wang, William Clifford, Charles Markham, Tomas Ward, Catherine Deegan
Conference Papers
This study used the traditional P300 speller paradigm to compare a medical grade Electroencephalography (EEG) system, the G.Tec, with a consumer grade EEG system, the Emotiv, in the detection of P300 components within Event Related Potential (ERP) signals. The experiment focused on four electrodes known to produce optically induced visual evoked potential. A successful comparison of the two approaches was made. It was shown that both systems could measure an ERP. The paper concludes with discussion comparing the low-cost wireless EEG system with the medical grade EEG system.
Improved Embedded Atom Method Potentials For Metal Hydride Systems, Robert Fuller
Improved Embedded Atom Method Potentials For Metal Hydride Systems, Robert Fuller
Theses, Dissertations and Capstones
Metal hydride systems are an important research topic in materials science because of their many practical, industrial, and scientific applications. Therefore, the development of reliable and efficient interatomic potentials for metal hydrides systems, to be utilized in molecular simulations, can be of great value in accelerating the research in this field. In this research, fully analytical interatomic Embedded Atom Method (EAM) potentials are developed for the PdAgH system. Ab initio simulations were performed to obtain the properties of selected PdAgH structures for fitting. The potentials are fit utilizing the central atom method without employing time-consuming molecular dynamics simulations in the …
Design And Simulation Of A Pneumatic Actuator Bending Soft Robotics Based On 3d Printing, Chenyu Zheng
Design And Simulation Of A Pneumatic Actuator Bending Soft Robotics Based On 3d Printing, Chenyu Zheng
Theses, Dissertations and Capstones
Robots mechatronic devices are able to replicate human actions, especially in dangerous environments and in manufacturing. Recently, the development of robotics has been inspired by bionics. The advanced robotics allow advanced robots to be used in new environments where they were not traditionally applicable, such as narrow and small spaces. Compared to traditional rigid robots, soft robots are made by deformable materials and possess high dexterity and adaptivity in harsh working environments. Traditional soft robots are made by casting. The method implies that the molds of soft robots should be designed and printed by a 3D printer first, before casting. …
Comparing And Enhancing The Analytical Model For Exposure Of A Retail Facility Layout With Human Performance, Bradley R. Guthrie, Pratik Parikh, Tyler Whitlock, Madison Glines, Thomas Wischgoll, John Flach, Scott Watamaniuk
Comparing And Enhancing The Analytical Model For Exposure Of A Retail Facility Layout With Human Performance, Bradley R. Guthrie, Pratik Parikh, Tyler Whitlock, Madison Glines, Thomas Wischgoll, John Flach, Scott Watamaniuk
Computer Science and Engineering Faculty Publications
Recent research in retail facility layout has focused on developing analytical models to estimate visibility measures of novel rack layouts based on assumptions about a shopper’s field of view. However, because of the human element involved in the shopping experience, it is vital to compare these models relative to actual human performance. In this study, we evaluate the predictions of our previously developed analytical model (that estimates exposure of every location on a given rack layout assuming expected head movement) in a 3D Virtual Environment (VE). We conducted trials with 18 participants who were asked to find targets strategically placed …
Carbon Nanotube Ultracapacitor Characteristics And Cell Design, Antonis A. Orphanou
Carbon Nanotube Ultracapacitor Characteristics And Cell Design, Antonis A. Orphanou
Engineering Ph.D. Theses
A model of carbon nanotube (CNT) ultracapacitor (CNU) as a high-performance energy storage device is developed based on simulations of electrolyte ion motions between cathode and anode. Using a molecular dynamics (MD) approach, the equilibrium positions of electrode charges interacting through Coulomb potential are determined, which in turn yield the equipotential surface and electric field associated with the capacitor. With an applied AC voltage, the current is computed from the nanotube and electrolyte particle distribution and interaction, resulting in a frequency-dependent CNU impedance. From the current and impedance profiles, the Nyquist and Cyclic Voltammetry plots are then extracted. Results of …
Engineering News, Winter 2018, School Of Engineering
Engineering News, Winter 2018, School Of Engineering
Engineering News
No abstract provided.
Optimization Of Wavelength Selection For Multispectral Image Acquisition: A Case Study Of Atrial Ablation Lesions, Huda Asfour, S. Guan, Narine Muselimyan, Luther M. Swift, Murray Loew, Narine Sarvazyan
Optimization Of Wavelength Selection For Multispectral Image Acquisition: A Case Study Of Atrial Ablation Lesions, Huda Asfour, S. Guan, Narine Muselimyan, Luther M. Swift, Murray Loew, Narine Sarvazyan
Pharmacology and Physiology Faculty Publications
In vivo autofluorescence hyperspectral imaging of moving objects can be challenging due to motion artifacts and to the limited amount of acquired photons. To address both limitations, we selectively reduced the number of spectral bands while maintaining accurate target identification. Several downsampling approaches were applied to data obtained from the atrial tissue of adult pigs with sites of radiofrequency ablation lesions. Standard image qualifiers such as the mean square error, the peak signal-to-noise ratio, the structural similarity index map, and an accuracy index of lesion component images were used to quantify the effects of spectral binning, an increased spectral distance …
Mems Fabrication Of A Peristaltic Pump, Nicholas Amendola
Mems Fabrication Of A Peristaltic Pump, Nicholas Amendola
Journal of the Microelectronic Engineering Conference
No abstract provided.
Automated Droplet Manipulation Through Electrowetting On Dielectric For Solid-Phase Oligonucleotide Synthesis, Hee Tae An
Journal of the Microelectronic Engineering Conference
No abstract provided.
Installation And Operation Of An Inductively-Coupled Plasma (Icp) Etcher, Eve Arnold
Installation And Operation Of An Inductively-Coupled Plasma (Icp) Etcher, Eve Arnold
Journal of the Microelectronic Engineering Conference
This project follows the design of the full timeline of an equipment installation in a microelectronics cleanroom, from developing an understanding of the tool through preparation of facilities, installation of the tool, and setup for use. The tool installed is a Plasmatherm Apex SLR Inductively-Coupled Plasma (ICP) Etcher manufactured by Advanced Vacuum. This tool was purchased by an RIT professor for ICP etching on III-V substrates, a new capability for the RIT SMFL. Installed additionally are the auxiliary equipment units, including two chillers, a Gas Reactor Column (GRC), and a roughing pump. The operation of the main tool for processing …
Installation And Operation Of An Inductively-Coupled Plasma (Icp) Etcher, Eve Arnold
Installation And Operation Of An Inductively-Coupled Plasma (Icp) Etcher, Eve Arnold
Journal of the Microelectronic Engineering Conference
No abstract provided.
Installation And Operation Of An Inductively-Coupled Plasma (Icp) Etcher, Eve Arnold
Installation And Operation Of An Inductively-Coupled Plasma (Icp) Etcher, Eve Arnold
Journal of the Microelectronic Engineering Conference
No abstract provided.
Characterization Of Alsi And Alsi-Tisi2 Metal-Semiconductor Contacts, Mark Davis
Characterization Of Alsi And Alsi-Tisi2 Metal-Semiconductor Contacts, Mark Davis
Journal of the Microelectronic Engineering Conference
No abstract provided.
Characterization Of Alsi And Alsi-Tisi2 Metal-Semiconductor Contacts, Mark Davis
Characterization Of Alsi And Alsi-Tisi2 Metal-Semiconductor Contacts, Mark Davis
Journal of the Microelectronic Engineering Conference
No abstract provided.
Pulsatory Mixing Of Laminar Flow Using Bubble-Driven Micro-Pumps, Brandon Hayes, Austin Hayes, Matthew Rolleston, Alexander Ferreira, James Krisher
Pulsatory Mixing Of Laminar Flow Using Bubble-Driven Micro-Pumps, Brandon Hayes, Austin Hayes, Matthew Rolleston, Alexander Ferreira, James Krisher
Journal of the Microelectronic Engineering Conference
Microfluidics differ from conventional fluid flows in that viscous forces dominate. As a result, microfluidics offer unprecedented control over fluid flows. The precise manipulation of fluids can be applied anywhere from healthcare in medical diagnostics to pharmaceutical companies miniaturizing reactions to reduce reagent consumption. In order to apply microfluidics as a comprehensive solution, unit operations must be performed – such as mixing, sorting, dilution, and much more. This work investigates mixing using thermal inkjet technology. Unlike macroscopic fluid flows with turbulence, transport phenomena become restricted in microfluidics. Active mixing approaches apply external forces (such as thermal or electric) to enhance …
Pulsatory Mixing Of Laminar Flow Using Bubble-Driven Micro-Pumps, Brandon Hayes, Austin Hayes, Matthew Rolleston, Alexander Ferreira, James Krisher
Pulsatory Mixing Of Laminar Flow Using Bubble-Driven Micro-Pumps, Brandon Hayes, Austin Hayes, Matthew Rolleston, Alexander Ferreira, James Krisher
Journal of the Microelectronic Engineering Conference
No abstract provided.
Pulsatory Mixing Of Laminar Flow Using Bubble-Driven Micro-Pumps, Matthew Rolleston, Brandon Hayes
Pulsatory Mixing Of Laminar Flow Using Bubble-Driven Micro-Pumps, Matthew Rolleston, Brandon Hayes
Journal of the Microelectronic Engineering Conference
No abstract provided.
Design And Fabrication Of A Three-Axis Capacitive Accelerometer, Eddie Huang
Design And Fabrication Of A Three-Axis Capacitive Accelerometer, Eddie Huang
Journal of the Microelectronic Engineering Conference
No abstract provided.
Fabrication And Characterization Of High-K Al2o3 And Hfo2 Capacitors, Jesse Judd
Fabrication And Characterization Of High-K Al2o3 And Hfo2 Capacitors, Jesse Judd
Journal of the Microelectronic Engineering Conference
No abstract provided.