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Articles 75421 - 75450 of 196126

Full-Text Articles in Engineering

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala Aug 2018

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala

The Summer Undergraduate Research Fellowship (SURF) Symposium

The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …

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Improving Biomanufacturing Production With Novel Elp-Based Transcriptional Regulators, Juya Jeon, Logan R. Readnour, Kevin V. Solomon Aug 2018

Improving Biomanufacturing Production With Novel Elp-Based Transcriptional Regulators, Juya Jeon, Logan R. Readnour, Kevin V. Solomon

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microbes can be used to produce valuable drugs, chemicals, and biofuels, but their potential has not been fully realized due to low production yields. To improve biomanufacturing processes and yield, we are developing novel, transcriptional regulators using biosynthesis technology in order to improve cellular health and overall production. Our regulator contains elastin-like polypeptides (ELPs), which make ideal sensors since they exhibit a sharp, inverse phase transition to indicators of cell health such as intracellular pH and ionic strength, and external stimuli such as temperature. We hypothesize that ELP can be fused to transcription factors to control expression of target genes. …

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Indoor Premise Plumbing: The Relationship Between Water Stagnation, Chlorine Decay, And Total Organic Carbon Levels, Emerson M. Ringger, Andrew J. Whelton, Tolulope Odimayomi, Maryam Salehi Aug 2018

Indoor Premise Plumbing: The Relationship Between Water Stagnation, Chlorine Decay, And Total Organic Carbon Levels, Emerson M. Ringger, Andrew J. Whelton, Tolulope Odimayomi, Maryam Salehi

The Summer Undergraduate Research Fellowship (SURF) Symposium

Drinking water safety is critical to the health of populations worldwide, and modern plumbing infrastructure can influence drinking water chemical characteristics. Inside residential and commercial buildings however, water use and contact with different plumbing components can vary. For example, water can endure lengthy stagnation periods and residual disinfectant agents like chlorine can decay, leaving the water vulnerable to microbial growth. Plastic cross-linked polyethylene (PEX) pipes have become popular and have shown to influence water quality. While several studies have been carried out on chemical leaching from PEX piping, none were found that examined the role of pipe diameter in relation …

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Spatial Variation Of Surface Residual Stress In Metallic Materials, Chengyang Zhang, David Bahr, Siavash Ghanbari, Raheleh Mohammad Rahimi Aug 2018

Spatial Variation Of Surface Residual Stress In Metallic Materials, Chengyang Zhang, David Bahr, Siavash Ghanbari, Raheleh Mohammad Rahimi

The Summer Undergraduate Research Fellowship (SURF) Symposium

Shot peening is commonly used to reduce fatigue failures in industrial parts by introducing compressive residual stress into the surface of a material. However, it is challenging to assess the performance of the parts without destroying them. Solving this problem requires a combined model that predicts both recrystallization and residual stress using experimental measurements and predictive computational modelling. Experiments were performed to prove that the surface properties of materials after thermal treatments can be accessed, and the spatial variation of residual stress in metallic materials, including the relationship between surface and subsurface behavior can be evaluated. This process involves investigating …

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Fluidic Control With Wax Valves For Paper-Based Diagnostics, Emilie I. Newsham, Elizabeth A. Phillips, Katherine N. Clayton, Jacqueline C. Linnes Aug 2018

Fluidic Control With Wax Valves For Paper-Based Diagnostics, Emilie I. Newsham, Elizabeth A. Phillips, Katherine N. Clayton, Jacqueline C. Linnes

The Summer Undergraduate Research Fellowship (SURF) Symposium

Paper-fluidic devices are a common platform for point-of-care disease detection in under-resourced areas because of their low cost and minimal instrumentation requirements. Limited fluidic control in paper-fluidic devices has hindered the incorporation of multistep reactions that are necessary for more sensitive disease detection. One potential fluidic control mechanism is the incorporation of thermally actuated wax valves to separate assay stages. Such valving would expand the detection capabilities of these devices by permitting fluid obstruction for sustained reactions and facilitating controlled volume release within a fully-automated, self-contained device. Despite the potential to exploit wax valves for innovative paper-fluidic diagnostics, a thorough, …

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Spice Based Compact Model For Electrical Switching Of Antiferromagnet, Xe Jin Chan, Jan Kaiser, Pramey Upadhyaya Aug 2018

Spice Based Compact Model For Electrical Switching Of Antiferromagnet, Xe Jin Chan, Jan Kaiser, Pramey Upadhyaya

The Summer Undergraduate Research Fellowship (SURF) Symposium

A simulation framework that can model the behavior of antiferromagnets (AFMs) is essential to building novel high-speed devices. The electrical switching of AFMs allows for high performance memory applications. With new phenomena in spintronics being discovered, there is a need for flexible and expandable models. With that in mind, we developed a model for AFMs which can be used to simulate AFM switching behavior in SPICE. This approach can be modified for adding modules, keeping pace with new developments. The proposed AFM switching model is based on the Landau-Lifshitz-Gilbert equation (LLG). LLG along with an exchange coupling module is implemented …

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Deep Neural Network Architectures For Modulation Classification Using Principal Component Analysis, Sharan Ramjee, Shengtai Ju, Diyu Yang, Aly El Gamal Aug 2018

Deep Neural Network Architectures For Modulation Classification Using Principal Component Analysis, Sharan Ramjee, Shengtai Ju, Diyu Yang, Aly El Gamal

The Summer Undergraduate Research Fellowship (SURF) Symposium

In this work, we investigate the application of Principal Component Analysis to the task of wireless signal modulation recognition using deep neural network architectures. Sampling signals at the Nyquist rate, which is often very high, requires a large amount of energy and space to collect and store the samples. Moreover, the time taken to train neural networks for the task of modulation classification is large due to the large number of samples. These problems can be drastically reduced using Principal Component Analysis, which is a technique that allows us to reduce the dimensionality or number of features of the samples …

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Design Of Selectively Compliant Morphing Wind Turbine Blade Section Using Bistable Laminate For Passive Load Alleviation, Abhishek Chopra, Dr. Andres Arrieta, Janav Udani, Jose Rivas Padilla Aug 2018

Design Of Selectively Compliant Morphing Wind Turbine Blade Section Using Bistable Laminate For Passive Load Alleviation, Abhishek Chopra, Dr. Andres Arrieta, Janav Udani, Jose Rivas Padilla

The Summer Undergraduate Research Fellowship (SURF) Symposium

The design of passively controlled compliant morphing structures for large scale wind turbine blades has been of interest due to the inherent advantages of lower mass and reduced complexity over their active counterparts. Previous studies have indicated that embedding a locally bi-stable element within the turbine blade section successfully allows for achieving passive load alleviation. The embedded bi-stable member switches from one stable state to another at a critical aerodynamic load. This local structural change results in a global shift in the aeroelastic response of the blade section. Building on these preliminary results, this research investigates a two- dimensional wind …

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Magnetically Actuated Cell Stretching Platform To Induce Phenotypic Changes In Metastatic Cells, Yong Gyun Cho, Hyunsu Park, Hyowon Lee, Sarah Libring Aug 2018

Magnetically Actuated Cell Stretching Platform To Induce Phenotypic Changes In Metastatic Cells, Yong Gyun Cho, Hyunsu Park, Hyowon Lee, Sarah Libring

The Summer Undergraduate Research Fellowship (SURF) Symposium

Although metastasis is responsible for about 90% of cancer deaths, only few in vitro models can be used to evaluate dynamic behaviors of metastatic cancer cells. Many studies have shown that mechanical stimuli can trigger various cellular responses such as gene and protein expression, which could lead to changes in cellular phenotype. Similarly, metastasized breast cancer cells in the lung tissue are constantly stretched by cyclic mechanical stress due to breathing, which alters cellular morphology and proliferation state. Such transitions can make the secondary tumors resistant to the chemotherapy used to effectively treat the primary tumors. In this work, we …

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Universality In Viscous Fluid Spreading And Leveling, Zoë S. Penko, Ivan C. Christov, Daihui Lu Aug 2018

Universality In Viscous Fluid Spreading And Leveling, Zoë S. Penko, Ivan C. Christov, Daihui Lu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Multiphase fluid flows, or flows where the dynamics of an interface between unlike fluids can be observed, require study to further understand the fundamental relationships of the fluids’ properties and their dynamics in multiple applications. The scope of this research project pertains to low Reynolds number flow, a dense fluid spreading through a less dense ambient fluid, with the spreading fluid movement being driven by gravitational buoyancy forces and density differences. The primary investigation involves studying the spreading and leveling of such fluids in shaped geometries, such as subsurface fractures. The objective is to determine the effect of a wide …

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Robust Allocation Of Funds For Nonstructural Flood Risk Mitigation In Coastal Louisiana, Simón Gómez Sierra, David R. Johnson, Matthew P. Shisler, Zachariah T. Richardson Aug 2018

Robust Allocation Of Funds For Nonstructural Flood Risk Mitigation In Coastal Louisiana, Simón Gómez Sierra, David R. Johnson, Matthew P. Shisler, Zachariah T. Richardson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Coastal Louisiana is a critical economic, ecological and cultural asset, acting as a major hub for waterborne commerce, fisheries, and the petrochemical industry, and also as one of the world’s unique wetlands. Unfortunately, this rich environment is in great danger from the threat of hurricanes and storm surge flooding. Direct economic losses are estimated to average $2.7 billion per year under current conditions, and this could increase to $12 billion a year, or more, within 50 years if nothing is done. To prevent this catastrophe, Louisiana has developed a Comprehensive Master Plan for a Sustainable Coast, which plans to spend …

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Computational Catalysis: Creating A User-Friendly Tool For Research And Education, Kevin P. Greenman, Peilin Liao Aug 2018

Computational Catalysis: Creating A User-Friendly Tool For Research And Education, Kevin P. Greenman, Peilin Liao

The Summer Undergraduate Research Fellowship (SURF) Symposium

Catalysis is used in a significant portion of production processes in the industrialized world, including most processing of chemicals and fuels. This makes maximizing the efficiency of catalysts a high priority. However, the immense number of candidates for new catalysts precludes the possibility of testing all of them by experiments. Density functional theory (DFT) has been widely and successfully used to calculate material properties relevant to catalysis and to screen promising candidates for experimental testing, but there currently exists no publicly- available, user-friendly tool for performing these DFT calculations. This work details the development of such a tool for nanoHUB.org …

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A High-Efficiency Low Power Rectifier For Wireless Power Transfer, Zachary Loy, Alden Fisher, Brian Vaughn, Dimitrios Peroulis Aug 2018

A High-Efficiency Low Power Rectifier For Wireless Power Transfer, Zachary Loy, Alden Fisher, Brian Vaughn, Dimitrios Peroulis

The Summer Undergraduate Research Fellowship (SURF) Symposium

With the number of implantable devices that utilize electronics increasing, there is an increasing need to find alternative ways of powering them. Currently, surgery is required to replace a battery for these devices; however, with advancements in Wireless Power Transfer (WPT) methods, the need for further surgeries will become negated. This paper explores the ability of WPT as an alternative powering method by investigating rectifier Power Conversion Efficiency (PCE). The rectifier converts high frequency waves to Direct Current (DC) energy that can provide usable power to devices requiring electrical power. It is targeted for low power applications centered around a …

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Load Distribution Of Adjacent Prestressed Concrete Box Beam Bridges, Luis F. Urrego, Ryan T. Whelchel, Robert J. Frosch, Christopher S. Williams Aug 2018

Load Distribution Of Adjacent Prestressed Concrete Box Beam Bridges, Luis F. Urrego, Ryan T. Whelchel, Robert J. Frosch, Christopher S. Williams

The Summer Undergraduate Research Fellowship (SURF) Symposium

One of the most common bridge types is the adjacent prestressed concrete box beam bridge because the system is economical and simple to build; over 43,000 are currently in service within the US. However, they are highly susceptible to strand corrosion and concrete deterioration which can result in early loss of load capacity. Therefore, an experimental program sponsored by the Indiana Department of Transportation (INDOT) was initiated to determine the behavior of deteriorated beams and develop recommendations for load rating and design of this bridge type. Displacement sensors were installed on a bridge in service to measure its deformation under …

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Neural Coding Of An Auditory Pitch Illusion, Maria Alejandra Barrera, Mark Sayles, Ravinderjit Singh Aug 2018

Neural Coding Of An Auditory Pitch Illusion, Maria Alejandra Barrera, Mark Sayles, Ravinderjit Singh

The Summer Undergraduate Research Fellowship (SURF) Symposium

Pitch is an important perceptual dimension in audition, supporting auditory object segregation, melody recognition and lexical distinction. Huggins’ pitch, for example, is a phenomenon evoked by two sources of broadband noise presented binaurally with an inter-aural phase shift over a narrow frequency band. Huggins’ pitch and other dichotic pitches have been studied extensively using perceptual experiments. Several models have been proposed to explain and predict the perception of pitch; however, no studies have tried to record in vivo neuron responses to Huggins’ pitch (HP) nor have tried to explain how the HP is coded by neurons. The existence of pitches …

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Virtual Reality For Baseball Batting, Fengchen Gong, Tianjie Jia, Hong Tan, Casey Kohr Aug 2018

Virtual Reality For Baseball Batting, Fengchen Gong, Tianjie Jia, Hong Tan, Casey Kohr

The Summer Undergraduate Research Fellowship (SURF) Symposium

Nowadays, researchers explore the applications of Virtual Reality in different aspects of people’s lives. A few studies of Virtual Reality focus on applications in sports training. In this research area, one of the most important benefits is that athletes can focus on the training of one specific skill at one time. This SURF project focuses on the development of the virtual reality environment by designing targeted training for baseball batters, with the goal to achieve sufficient realism as judged by the Purdue baseball coaches. With the Virtual Reality training, baseball batters can practice and perfect a specific skill without a …

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Electronic Effect Of Platinum Alloy Catalysts On Olefin Hydrogenation Kinetics, Colin Reedy, Jeff Miller, Stephen Purdy Aug 2018

Electronic Effect Of Platinum Alloy Catalysts On Olefin Hydrogenation Kinetics, Colin Reedy, Jeff Miller, Stephen Purdy

The Summer Undergraduate Research Fellowship (SURF) Symposium

Dehydrogenation of alkanes is the first step in transforming light hydrocarbons into liquid fuels and chemicals. This process has traditionally used platinum alloys as catalysts. Alloys are used industrially because they have a greater selectivity than monometallic platinum. Alloying platinum with an inactive promoter modifies the crystalline structure of the surface (geometric effect), and the 5d electrons in platinum responsible for chemistry (electronic effect); both have been suggested to be primarily responsible for dehydrogenation selectivity in platinum alloys. Alloy catalysts have been synthesized using early 3d transition metal promoters with the same Pt3M crystal structure. X-Ray Absorption Spectroscopy …

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Evaluation And Analysis Of Ethane Transformation To Liquid Hydrocarbons Through Steam Cracking, Christian Omar Villa Santos, Wasiu Peter Oladipupo, Taufik Ridha, Rakesh Agrawal Aug 2018

Evaluation And Analysis Of Ethane Transformation To Liquid Hydrocarbons Through Steam Cracking, Christian Omar Villa Santos, Wasiu Peter Oladipupo, Taufik Ridha, Rakesh Agrawal

The Summer Undergraduate Research Fellowship (SURF) Symposium

Process design and sensitivity studies for a steam cracking reactor was performed. Steam cracking is commonly employed to convert ethane to ethylene, a building block of many other products. Although this technology is generally employed at large scale (>6 Billion pounds of ethylene per year), understanding the process and its economic performance is critical to set target criteria for other processes under development. Aspen Plus was used to simulate the ethane steam cracking reactor and other process units. Sensitivity analysis was performed to determine the most efficient and cost-effective operation regarding product yield. The results show that the maximum …

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Grain Boundary Motion Analysis, Jeremy Marquardt, Xiaorong Cai, Marisol Koslowski Aug 2018

Grain Boundary Motion Analysis, Jeremy Marquardt, Xiaorong Cai, Marisol Koslowski

The Summer Undergraduate Research Fellowship (SURF) Symposium

Grain growth is a mechanism to relax residual stresses in thin films. These grains grow out of the thin film surface and are known as whiskers. These whiskers can cause short circuits, so developing scalable and cost effective solutions would increase the reliability and utility of tin electronics. A popular of method of examining tin whiskering is microscopic simulation, as it provides an accurate and cost effective way to predict the consequences of proposed models. Specifically examining the evolution of grain boundaries, this paper aims to present the results of grain boundary motion simulations through a generalized program that streamlines …

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Thienoisatin Oligomers As N-Type Molecular Semiconductors, Natalie M. Kadlubowski, Xuyi Luo, Jianguo Mei Aug 2018

Thienoisatin Oligomers As N-Type Molecular Semiconductors, Natalie M. Kadlubowski, Xuyi Luo, Jianguo Mei

The Summer Undergraduate Research Fellowship (SURF) Symposium

Organic field effect transistors (OFETs) offer many advantages compared to traditional inorganic transistors, such as flexibility and solution processability. In this study we design and synthesize two thienoisatin-based organic semiconducting small molecules, then investigate their electronic properties in n-type OFETs. To introduce n-type charge transport, electron-withdrawing dicarbonitrile moieties were installed on thienoisoindigo and bis-thienoisatin molecules, which led to a quinoidal conjugation on thienoisoindigo, while maintaining an aromatic conjugation on the bis-thienoisatin. Following the syntheses, the molecules were characterized to determine highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels via cyclic voltammetry, as well as any potential …

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Tissue Clearing As A Mechanism To Identify Changes In Fibronectin Structure During Breast Cancer Metastasis, Maryam Nuru, Kelsey Hopkins, Luis Solorio Aug 2018

Tissue Clearing As A Mechanism To Identify Changes In Fibronectin Structure During Breast Cancer Metastasis, Maryam Nuru, Kelsey Hopkins, Luis Solorio

The Summer Undergraduate Research Fellowship (SURF) Symposium

With metastasis accounting for approximately 90% of breast cancer deaths and an alarming number of over 300,000 new breast cancer cases to be diagnosed by the end of 2018, there is growing need to understand the process of breast cancer. Changes in the extracellular matrix (ECM) of the tumor microenvironment play an essential role in this deadly tumor progression. Specifically, the glycoprotein fibronectin (FN), has been identified to be up-regulated in patients with worse clinical outcomes. During tumor progression fibronectin undergoes conformational changes that aid in metastatic dissemination. In order to analyze the dynamic changes in FN expression and evaluate …

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Efvs Effects On Pilot Performance, Michael Campbell, Nsikak Udo-Imeh, Steven J. Landry Aug 2018

Efvs Effects On Pilot Performance, Michael Campbell, Nsikak Udo-Imeh, Steven J. Landry

The Summer Undergraduate Research Fellowship (SURF) Symposium

Flight tests have been conducted at Purdue University using a computer-based flying simulator in an attempt to determine and measure the effects of Enhanced Flight Vision Systems (EFVS) on the performance of pilots during landing. Knowledge of these effects could help guide future design and implementation of EFVS in modern commercial aircraft, and further increase pilots’ ability to control the aircraft in low-visibility conditions. The problem that has faced researchers in the past has revolved around the difficulty in interpreting the data which is generated by these tests. The difficulty in making a generalized conclusion based on the large amount …

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Short-Term Organic Carbon Release And Chlorine Disinfectant Decay For Cross-Linked Polyethylene (Pex) Plumbing Pipes, Miriam Tariq, Christian J. Ley, Maryam Salehi, Andrew J. Whelton Aug 2018

Short-Term Organic Carbon Release And Chlorine Disinfectant Decay For Cross-Linked Polyethylene (Pex) Plumbing Pipes, Miriam Tariq, Christian J. Ley, Maryam Salehi, Andrew J. Whelton

The Summer Undergraduate Research Fellowship (SURF) Symposium

The use of cross-linked polyethylene (PEX) plumbing pipes has grown in popularity for residential applications. However, PEX pipes can leach organic materials into water that can enable biofilm growth, cause off-tastes and -odors, and may react with disinfectants to form disinfection by-products (DBP). Varied manufacturing processes that are applied to create PEX pipes add to the complexity of understanding organic materials released. In this study, organic carbon release from three PEX pipe brands was monitored for up to five days using a series of stagnation periods. Seven stagnation periods of 1, 2, 4, 8, 24, 72, and 120 hours were …

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Characterization And Modeling Of Discontinuous Fiber Composites, Kenneth M. Serrano Rodriguez, Imad Hanhan, Ronald F. Agyei, Michael Sangid Aug 2018

Characterization And Modeling Of Discontinuous Fiber Composites, Kenneth M. Serrano Rodriguez, Imad Hanhan, Ronald F. Agyei, Michael Sangid

The Summer Undergraduate Research Fellowship (SURF) Symposium

Composite materials, which are light and strong, are of great interest to engineers in the aerospace industry. Specifically in this work, a discontinuous short fiber reinforced polymer composite whose matrix is Polypropylene and fibers are Electric-glass oriented in different directions was studied. The performance of this material is highly dependent on its microstructure, and therefore the objective of this research is to non-destructively characterize the microstructure of the composite material. This includes characterization of its fiber orientation and length, fiber volume fraction, and void volume fraction. To do this, X-ray micro-computed tomography has been used, providing two dimensional cross-sectional images …

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Targeted Epigenetic Editing Using Optogenetic Tools, Joshua Hahn, Chongli Yuan Aug 2018

Targeted Epigenetic Editing Using Optogenetic Tools, Joshua Hahn, Chongli Yuan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Epigenetics markers, such as DNA methylation and histone post-translational modifications, are modifications to the structure of DNA that impact gene expression without altering the genetic code. Among them, DNA methylation plays a critical role in various biological processes including the differentiation of stem cells, regulation of gene expression, and adaptation to environmental signals. The ability to modify DNA methylation at particular genes in various cell types is thus desirable for engineering specific cell phenotypes. Although technologies exist that can alter DNA methylation at target genes, these techniques lack spatial and temporal resolution and are not able to selectively edit individual …

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Developing An Electromechanical Carbon Dioxide Sensor For Occupancy Monitoring, Joshua L. Jenkins, Allison K. Murray, Jeffrey F. Rhoads Aug 2018

Developing An Electromechanical Carbon Dioxide Sensor For Occupancy Monitoring, Joshua L. Jenkins, Allison K. Murray, Jeffrey F. Rhoads

The Summer Undergraduate Research Fellowship (SURF) Symposium

The Energy Information Administration reported in 2012 that heating and cooling processes consume nearly 35% of the total energy used by commercial buildings. In an effort to limit the amount of energy wasted in conditioning empty buildings and rooms, various occupancy detection techniques have been developed that can be paired with a smart heating, ventilation, and air conditioning (HVAC) control system. This work focused on the development of a novel carbon dioxide detector that is sensitive enough to accurately determine if, and when, a room is occupied. To test the new sensor design, a customized chamber with gas inlets was …

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Reliability Of Lead-Free Solder Joints Under Combined Shear And Compressive Loads, Ian Bernander, Travis Dale, Yuvraj Singh, Ganesh Subbarayan Aug 2018

Reliability Of Lead-Free Solder Joints Under Combined Shear And Compressive Loads, Ian Bernander, Travis Dale, Yuvraj Singh, Ganesh Subbarayan

The Summer Undergraduate Research Fellowship (SURF) Symposium

In electronic assemblies, solder joints are used to create electrical connections, remove heat, and mechanically support the components. When an electronic device is powered on, the solder joints and the board they are attached to heat up, expanding at different rates. Due to the difference in expansion, shear stress is imposed on the solder joints. As the device is powered on and off, this shear stress can eventually fracture the solder joint, causing the device to fail. Therefore, to increase the lifespan of electronics, it is important to investigate the mechanical properties of solder alloys. The present study investigates how …

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High-Throughput Nanoliter Dispensing Device For Biological Applications, Cole Reynolds, Euiwon Bae Dr., J Paul Robinson Dr. Aug 2018

High-Throughput Nanoliter Dispensing Device For Biological Applications, Cole Reynolds, Euiwon Bae Dr., J Paul Robinson Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Pathogen identification is a field that can contribute largely to the prevention of the spreading of illness and disease. In the past, pathogen identification has been a long and arduous process due to the time-consuming processes and steps that requires technician’s time and effort. With new technologies emerging however, screening of bacteria colonies can be done in a quick and high-throughput way. The problem is that using the current methods, bacteria cannot be transferred to petri dishes fast enough to keep up with the new screening methods. The current study focuses on exploring different methods to create an ergonomic device …

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Creating A Mammary Duct Model To Study The Effects Of Cancer Heterogeneity On Tumor Metastasis, Megan Hofstetter, Mazin Hakim, Luis Solorio Aug 2018

Creating A Mammary Duct Model To Study The Effects Of Cancer Heterogeneity On Tumor Metastasis, Megan Hofstetter, Mazin Hakim, Luis Solorio

The Summer Undergraduate Research Fellowship (SURF) Symposium

During tumor progression, the process of clonal evolution gives rise to a variety of cell subpopulations that cause differential sensitivity to drugs and give rise to cell populations with the ability to metastasize, there are many mouse models available that can be used to study tumor progression and metastasis. However, there is a lack of models to study the effect of tumor heterogeneity using human cancers. Xenograft based systems require the use of immunodeficient mice, which limits the use of the model to evaluate microenvironmental factors involved in metastatic dissemination. Humanized mouse models with established human immune systems have been …

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Steady-State Method To Measure The In-Plane Thermal Conductivity Of Thin Sheet Materials, Evgeny Pakhomenko, Andrew James Wildridge, Abraham Mathew Koshy, Souvik Das, Andreas Jung Aug 2018

Steady-State Method To Measure The In-Plane Thermal Conductivity Of Thin Sheet Materials, Evgeny Pakhomenko, Andrew James Wildridge, Abraham Mathew Koshy, Souvik Das, Andreas Jung

The Summer Undergraduate Research Fellowship (SURF) Symposium

A new generation of silicon pixel detectors is required to cope with the unprecedented luminosities at the high-luminosity phase of the Large Hadron Collider (HL-LHC) in 2025. The HL-LHC provides a high radiation, high interaction rate environment for the innermost detector region of the CMS detector. This can lead to an uncontrolled increase in temperature of the detector that can destroy the silicon pixels. Moreover, too high operating temperature can add noise to the data obtained from the detector and can slow the read out cheap down. Therefore, the Phase II upgrade to the Compact Muon Solenoid (CMS) experiment requires …

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