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Articles 71641 - 71670 of 196672

Full-Text Articles in Engineering

Impact Of Natural Fracture Induced Elastic Anisotropy On Completion And Hydraulic Fracturing Designs, Emre Can Dundar Jan 2019

Impact Of Natural Fracture Induced Elastic Anisotropy On Completion And Hydraulic Fracturing Designs, Emre Can Dundar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Shale has been usually recognized as a transverse isotropic (TI) medium in conventional geomechanical log interpretation due to its laminated nature. However, when natural fractures (NFs) exist in the rock body, additional elastic anisotropy can be introduced, converting Shale to an orthorhombic (OB) medium. Previous study illustrates that treating the naturally fractured shale rock as a TI medium by ignoring the NF-induced anisotropy can cause the erroneous estimation of the geomechanical properties (i.e. Young’s modulus, Poisson’s ratio, brittleness index, and etc.) and in-situ stress. In this paper, the study is extended to quantify the impact of NF-induced elastic anisotropy on …


Deformation Correlations And Machine Learning: Microstructural Inference And Crystal Plasticity Predictions, Michail Tzimas Jan 2019

Deformation Correlations And Machine Learning: Microstructural Inference And Crystal Plasticity Predictions, Michail Tzimas

Graduate Theses, Dissertations, and Problem Reports (ETD)

The present thesis makes a connection between spatially resolved strain correlations and material processing history. Such correlations can be used to infer and classify prior deformation history of a sample at various strain levels with the use of Machine Learning approaches. A simple and concrete example of uniaxially compressed crystalline thin films of various sizes, generated by two-dimensional discrete dislocation plasticity simulations is examined. At the nanoscale, thin films exhibit yield-strength size effects with noisy mechanical responses which create an interesting challenge for the application of Machine Learning techniques. Moreover, this thesis demonstrates the prediction of the average mechanical responses …


Reflectivity And Photoemission Electron Microscopy Studies Of Magnetic Heterostructures, Chih-Yeh Huang Jan 2019

Reflectivity And Photoemission Electron Microscopy Studies Of Magnetic Heterostructures, Chih-Yeh Huang

Graduate Theses, Dissertations, and Problem Reports (ETD)

When a thin film thickness becomes ultrathin, the magnetic properties of the thin film can be altered, degraded or even lost. The loss of magnetism has been called the magnetic dead layer (MDL). Considering the trend for miniaturization of information storage and other devices, the MDL is a significant challenge for materials science and engineering. La1-xSrxMnO3 (LSMO) with x=0.3 is an excellent model material that exhibits ferromagnetism at room temperature to study the MDL. This dissertation focuses on understanding the MDL in LSMO films on their own and the effect of this dead layer when …


Mechanism Study Of Shale Gas Conversion Via Chemical Looping And Heterocatalytic Processes, Lei Bai Jan 2019

Mechanism Study Of Shale Gas Conversion Via Chemical Looping And Heterocatalytic Processes, Lei Bai

Graduate Theses, Dissertations, and Problem Reports (ETD)

The shale gas revolution has significantly changed the energy landscape in US. The technical-feasible, energy-effective schemes for shale gas combustion and utilization, especially from remote resources, have attracted increasing interest due to expensive transportation/distribution cost. In this research, for the first time, chemical looping combustion (CLC) of methane with inherent CO2 capture, oxidative coupling of methane (OCM) and dehydro-aromatization (DHA) of ethane are systematically studied as promising alternatives at O2-rich, O2-lean and non-oxidative conditions, respectively.

Chemical looping combustion is bridging clean fuel combustion in energy production with inherent CO2 capture. CLC utilized an oxygen …


Modeling And Development Of The Dynamic Environmental Simulation Chamber (Desc) For Calibration Of Air Quality Monitoring Sensors, Filiz Kazan Jan 2019

Modeling And Development Of The Dynamic Environmental Simulation Chamber (Desc) For Calibration Of Air Quality Monitoring Sensors, Filiz Kazan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The thesis describes the development steps for the dynamic environmental simulation chamber (DESC) and carbon dioxide sensor calibration by using DESC. The sensors are Figaro, COZIR and K30 CO2 sensors


Retaining Wall System With Soldier Pile And Composite Resin Infused Lagging Elements, Shane Phillip Moore Jan 2019

Retaining Wall System With Soldier Pile And Composite Resin Infused Lagging Elements, Shane Phillip Moore

Graduate Theses, Dissertations, and Problem Reports (ETD)

Retaining walls are used as an alternative to installing drainage and soil reinforcement, depending on site conditions. This report discusses the design of a retaining wall with steel soldier piles and lagging elements for rocky slopes. The design consists of six different options, three options with a span of eight feet and three options with a span of ten feet between soldier piles. The three options for both spans are the same concept but designed for different load conditions. These options include: timber with glass fiber reinforced polymers (GFRP) wraps, reinforced concrete with GFRP wraps, and an FRP Prodeck system …


Design Of Dual-Band Rf-Dc Rectifier And Dc-Dc Boost Converter For Energy Harvesting Applications, Merghani K. Merghani Jan 2019

Design Of Dual-Band Rf-Dc Rectifier And Dc-Dc Boost Converter For Energy Harvesting Applications, Merghani K. Merghani

Theses

Wireless sensors are used in many industrial and commercial applications. However powering up those sensors is challenging, because batteries have limited lifetime, require periodic maintenance, and their depositions are toxic to the environment. One of the new methods to power up those small sensors is to capture energy from ambient sources and convert it into a steady dc output voltage, which is known as energy harvesting or scavenging. In this thesis, we propose an energy harvesting method by scavenging the electromagnetic (EM), or radio frequency (RF) energy in the ambient and converting it into a steady dc output voltage that …


Immune Modulation By Amphiphilic Oligonucleotides, Chunsong Yu Jan 2019

Immune Modulation By Amphiphilic Oligonucleotides, Chunsong Yu

Wayne State University Dissertations

Immunotherapy is emerging as one of the most promising therapeutic strategies for cancer treatment in clinical practice. Immunotherapy leverages the host’s immune system to attack and kill tumor cells. Rationally-designed cancer vaccines are emerging as one of the powerful immunotherapies primarily because of the promise of inducing tumor antigen-specific immune responses. To improve immunogenicity of cancer vaccines, vaccine antigens are administered with vaccine adjuvants which can robustly activate innate immune system and subsequently lead to adaptive immune response. However, the major challenge of achieving significant therapeutic efficacy is lack of efficient targeted-delivery of vaccine components. By taking advantage of endogenous …


Novel Cathode Framework, Effective Electrolyte Modification, And Electrode Structural Modification Of High Performance Lithium Sulfur Batteries, Wenduo Zeng Jan 2019

Novel Cathode Framework, Effective Electrolyte Modification, And Electrode Structural Modification Of High Performance Lithium Sulfur Batteries, Wenduo Zeng

Wayne State University Dissertations

Firstly, TiN nanotube arrays have been investigated as an effective skeleton in the cathode of lithium-sulfur batteries. A series of TiN nanotubes with various diameter and length have been synthesized and tested. Moreover, graphene nanoplatelets have been utilized as a structural anchor to support the TiN nanotubes, and the synergetic effect of composite material and its enhancement on Li-S battery electrochemical performance and cycling stability have been studied. Secondly, the improvement of electrode structural design has been evaluated for their effectiveness by using an in-situ characterization method with other electrochemical characterization. Lastly, the facile method of using transition metal cations …


Direct Laser Metal Deposition Of Nickel Based Superalloys, Abhishek Ramakrishnan-Sudha Jan 2019

Direct Laser Metal Deposition Of Nickel Based Superalloys, Abhishek Ramakrishnan-Sudha

Wayne State University Dissertations

Nickel-based superalloys are substantially used in the manufacturing of boilers for ultra-supercritical power plants and gas turbine hot-section as this grade of alloys provide higher yield strength with the rise in operating temperature and pressure owing to the presence of γʹ second phase precipitates. Conventionally, casting techniques such as centrifugal casting, investment casting, vacuum molding and several other casting based methods are used to fabricate the hot-section components. Nevertheless, a need for designing advanced materials with complex designs such as geometry, microstructure control, compositional changes, microstructure and property varying with the location as in functionally graded materials is not viable …


Programming Of Collaborative Robot (Cobot) To Selectively Disassemble Products To Obtain Critical Materials, Brittany Felder Jan 2019

Programming Of Collaborative Robot (Cobot) To Selectively Disassemble Products To Obtain Critical Materials, Brittany Felder

Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19

End-of-life products that contain critical materials, such as rare earth magnets, are often discarded even though there is remaining value that can be fed back into a remanufacturing process. This research aims to develop high throughput and economic value recovery from electric machines using collaborative robotics.


Multi-Responsive Macromolecular Coacervate Complexes For Efficient Biomolecular Encapsulation And Controlled Release, Adrian Lorenzana Jan 2019

Multi-Responsive Macromolecular Coacervate Complexes For Efficient Biomolecular Encapsulation And Controlled Release, Adrian Lorenzana

Research Opportunities for Engineering Undergraduates (ROEU) Program 2018-19

The project investigates the mechanistic (entropic) formation of organic-inorganic coacervates with improved mechanical strength. We seek to control and modify material properties and stimuli-responsive characteristics of hybrid coacervates, and to explore new practical applications of organic-inorganic coacervate complexes, i.e. (bio)separation, wastewater treatment, drug delivery, battery electrolyte and electrodes.


Ros-Based Sensor Fusion And Motion Planning For Autonomous Vehicles: Application To Automated Parkinig System, Yuanzhe Li Jan 2019

Ros-Based Sensor Fusion And Motion Planning For Autonomous Vehicles: Application To Automated Parkinig System, Yuanzhe Li

Wayne State University Theses

Research and development in autonomous vehicles are currently very active since these vehicles are expected to play an important role in future transportation. During the past decade, numerous Advanced Driver Assistance Systems (ADAS) features have been developed and implemented on production vehicles, such as Adaptive Cruise Control and Lane Keeping Assist. However, most ADAS features are aimed to assist driving on highways where the environments are usually more structured and decision making can be made more easily. Non-highway environments, such as in the case of self-parking, are unstructured and requires more complicated analysis of the image information, localization and path …


Molecular Exchange Monte Carlo. A Generalized Method For Identity Exchanges In Grand Canonical Monte Carlo Simulations, Mohammad Soroush Barhaghi Jan 2019

Molecular Exchange Monte Carlo. A Generalized Method For Identity Exchanges In Grand Canonical Monte Carlo Simulations, Mohammad Soroush Barhaghi

Wayne State University Theses

A generalized identity exchange algorithm is presented for Monte Carlo simulations in the grand canonical ensemble. The algorithm, referred to as Molecular Exchange Monte Carlo (MEMC), may be applied to multicomponent systems of arbitrary molecular topology, and provides significant enhancements in the sampling of phase space over a wide range of compositions and temperatures. Three different approaches are presented for the insertion of large molecules, and the pros and cons of each method are discussed. The performance of the algorithms is highlighted through grand canonical Monte Carlo histogram-reweighting simulations performed on several systems, including 2,2,4-trimethylpentane+neopentane, butane+perfluorobutane, methane+n-alkanes, and water+impurity. Relative …


A Formal Systems Engineering Methodology For Cyber-Physical Systems: The Verifiable Design Process, Nadew S. Kibret Jan 2019

A Formal Systems Engineering Methodology For Cyber-Physical Systems: The Verifiable Design Process, Nadew S. Kibret

Dissertations

Cyber-physical systems (CPS) are systems that exhibit tight integration between their physical and computational components. They are hybrid systems containing continuous states and discrete states emanating from the physical and computational components, respectively. Systems engineering of these systems is challenging due to the tight integration of their computational, physical and communication technologies. As their level of acceptance increases in mission critical applications such as health care, smart grid, autonomous vehicles and smart cities, the need to ensure their safe operation is paramount importance as well. Therefore, design methodologies followed in their development are required to result in system behavior that …


Comparison Study Of Supervised Machine Learning Algorithms For Real Time Prediction Of Uav Behaviors, Brian Baity Jan 2019

Comparison Study Of Supervised Machine Learning Algorithms For Real Time Prediction Of Uav Behaviors, Brian Baity

Theses

An American scientific writer/critic of the mid-20th century, Joseph Wood Krutch, stated, “Technology made large populations possible: large populations now make technology indispensable.” Unmanned aerial vehicles (UAVs) have become a vital part of society, evolving from solely military use to commercial and even personal day-to-day use. UAV application has grown for mobility on demand, increasing the number of UAVs in the sky. Consequently, more UAVs increases the possibility of aerial collisions, challenging the safety of passengers flying and bystanders on the ground. Understanding the behavior of UAVs and unmanned aerial systems (UAS) in general, therefore, will decrease the possibility of …


The Concept Of Substrate Integrated Circularly Polarized Horn Antennas, Venkata Naga Kalyan Ram Akunuru Jan 2019

The Concept Of Substrate Integrated Circularly Polarized Horn Antennas, Venkata Naga Kalyan Ram Akunuru

All Graduate Theses, Dissertations, and Other Capstone Projects

In this thesis, a new type of Substrate Integrated Waveguide for Horn Antennas is proposed for implementing circularly polarization on printed circuit boards. E-plane type of circuits cannot be realized by the conventional substrate integrated waveguide. Substrate integrated E-plane waveguide consists of two circuit boards attached to each other by the two copper strips which are inserted in between two circuit boards, where plated through holes are penetrated through them along the transmission direction. The plated through holes and copper strips altogether played as side walls of a conventional waveguide to support longitudinal and vertical currents. Circular Polarization has its …


This Is The Last Straw: Reducing Plastic Straw Usage On A College Campus, Rajalakshmi Somasundaram Jan 2019

This Is The Last Straw: Reducing Plastic Straw Usage On A College Campus, Rajalakshmi Somasundaram

Graduate Theses - Engineering Management

Six Sigma is a disciplined, data-driven approach and methodology developed by Motorola in the mid-1980’s to optimize processes. Six Sigma allows for a quantitative study of a process with the goal of improving the quality of the output of the process by removing the causes of defects and reducing variability in the process. The methodology has been applied in numerous industries, such as manufacturing, healthcare, and education. Statistically speaking, it drives a process towards six sigma by centering the process’s mean and decreasing its standard deviation so that the distance between its mean and nearest specification limit is six standard …


Preliminary Examination Of The Effects Of Time And Flexural Direction On An Anisotropic Geosynthetic Cementitious Composite Mat, James M. Proctor Jan 2019

Preliminary Examination Of The Effects Of Time And Flexural Direction On An Anisotropic Geosynthetic Cementitious Composite Mat, James M. Proctor

Undergraduate Honors Theses

The significance of this research was to determine the effect the main fabric weave direction and cure time has on the maximum load of 0.34 inch anisotropic Geosynthetic Cementitious Composite Mat sample coupons. Two series of tests were run. The first used a three-point bend test on the material samples with varying cure times to determine the average maximum load associated with each. The second series of testing used followed ASTM D8030/D8030M - 16 for sample preparation and ASTM D8058 - 17 for testing to determine the flexural strength and modulus of elasticity of the test samples with and against …


Comparative Analysis Of Bolted Joint Assemblies Subjected To Cyclical Transverse Mechanical Stress, Carlton Drew Harris Jan 2019

Comparative Analysis Of Bolted Joint Assemblies Subjected To Cyclical Transverse Mechanical Stress, Carlton Drew Harris

Undergraduate Honors Theses

This research was conducted to determine the effectiveness of commonly-used washers in engineering structures by observing the difference in applied torque specifications and torque required to loosen bolted joint assemblies after being subjected to cyclical transverse mechanical stress. Two types of washers were tested: flat washers and split-ring helical lock washers. The physical concepts tested throughout this paper are theorized to scale to any size of bolted joint assembly. Based on the variables tested, the results are inconclusive. While the observed results did display the assemblies paired with split-ring helical lock washers required- on average- a greater force to loosen …


Strategies To Mitigate Supply Chain Disruption Risks, Daniel G. Haloukas Jan 2019

Strategies To Mitigate Supply Chain Disruption Risks, Daniel G. Haloukas

Walden Dissertations and Doctoral Studies

Businesses with global supply chains typically have a minimum of 1 interruption to their supply chain annually, which can decrease profitability and affect overall company performance. The purpose of this multiple case study was to explore strategies personal care business supply chain managers used to mitigate supply chain disruption risk. The targeted population was 9 supply chain managers working in 5 different Fortune 500 consumer packaged goods personal care companies in the northeastern United States who have successfully used strategies to mitigate supply chain disruptions. Corporate risk management was used as the conceptual framework of the study to determine how …


Solar Tracker Renewable Energy, Stephanie Christie, Annabeth Helmly, Matthew Smith, Katrina Vaughan Jan 2019

Solar Tracker Renewable Energy, Stephanie Christie, Annabeth Helmly, Matthew Smith, Katrina Vaughan

ENgaging Educators in Renewable enerGY (ENERGY): Lesson Plans & Slideshows (2017-2019)

No abstract provided.


Electric Solid Propellant Ablation In An Arc Discharge, Matthew S. Glascock, Joshua L. Rovey, Kurt A. Polzin Jan 2019

Electric Solid Propellant Ablation In An Arc Discharge, Matthew S. Glascock, Joshua L. Rovey, Kurt A. Polzin

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Electric solid propellants are advanced solid chemical rocket propellants that can be controlled (ignited, throttled, and extinguished) through the application and removal of an electric current. Electric solid propellants are also being considered for pulsed arc ablation electric thrusters, such as the pulsed plasma thruster. The focus of this work is the electrical and ablation characteristics of electric solid propellant within an arc discharge. Arc discharges of 5–20 J per pulse were created within a cylindrical cavity, and results for the electric solid propellant are compared with polytetrafluoroethylene (PTFE), which is a traditional propellant in ablative pulsed plasma thrusters. The …


Experimental Investigation Of Mixtures Of 1-Ethyl-3-Methylimidazolium Ethyl Sulfate And Ethylammonium Nitrate With Electrospray Propulsion Applications, Mitchell J. Wainwright, Joshua L. Rovey, Shawn W. Miller, Benjamin D. Prince Jan 2019

Experimental Investigation Of Mixtures Of 1-Ethyl-3-Methylimidazolium Ethyl Sulfate And Ethylammonium Nitrate With Electrospray Propulsion Applications, Mitchell J. Wainwright, Joshua L. Rovey, Shawn W. Miller, Benjamin D. Prince

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Physical properties, performance metrics, and mass spectra of mixtures of two ionic liquids (1-ethyl-3-methylimidazolium ethyl-sulfate aka [Emim][EtSO4] and ethyl ammonium nitrate aka EAN) are investigated from the standpoint of electrospray propulsive characteristics. Spectra suggest that as the [Emim][EtSO4] mixture fraction increases, the intensity of [Emim][EtSO4] related species in the plume also increases, while the presence of EAN decreases. Spectra also show presence of both EAN proton transfer species and species related to chemical reaction of [EtSO4] and water. Despite the volatility of EAN, it emits stably into vacuum at low flow rates when mixed with 25% [Emim][EtSO4]. Spectra also show …


Hydroxylammonium Nitrate Species In A Monopropellant Electrospray Plume, Mitchell J. Wainwright, Joshua L. Rovey, Shawn W. Miller, Benjamin D. Prince, Steven P. Berg Jan 2019

Hydroxylammonium Nitrate Species In A Monopropellant Electrospray Plume, Mitchell J. Wainwright, Joshua L. Rovey, Shawn W. Miller, Benjamin D. Prince, Steven P. Berg

Mechanical and Aerospace Engineering Faculty Research & Creative Works

A mixture of 1-ethyl-3-methylimidazolium ethyl sulfate ([Emim][EtSO4]) and hydroxylammonium nitrate (HAN) is an energetic monopropellant potentially suitable in a multi-mode chemical-electric microtube-electrospray micro propulsion system. In this work, electrospray plume mass spectra are compared between the monopropellant mixture and neat [Emim][EtSO4]. This comparison clearly indicates new and additional species present in the plume due to the addition of HAN. Mass spectra from 20-600 amu/q were obtained over a variety of angles and flow rates from 2 pL/sec to 3 nL/sec in both cation and anion extraction modes. Mass spectrum dependence on flow rate and angular orientation agree qualitatively well with …


Perceptions Of Vulnerability To Flooding, Hurricanes, And Climate Change On Grand Isle, Louisiana’S Only Inhabited Barrier Island, Lauren Miller Jan 2019

Perceptions Of Vulnerability To Flooding, Hurricanes, And Climate Change On Grand Isle, Louisiana’S Only Inhabited Barrier Island, Lauren Miller

Graduate Student Theses, Dissertations, & Professional Papers

This study used in-depth interviews of permanent residents on Grand Isle, Louisiana, a remote barrier island, to better understand their perceptions of structural flood measures, non-structural responses to flooding and hurricanes, and perceptions of vulnerability to flooding, hurricanes, and climate change on a remote barrier island-Grand Isle, Louisiana. Residents' perceptions regarding the various structural measures implemented by the federal, state, and local government appeared mixed. Non-structural responses to flooding risks implemented at the household, community, state, and federal level continue to strengthen resiliency on Grand Isle. According to interviewees, aspects of environmental, rural, and economic vulnerability on Grand Isle impact …


Enhanced Quantum Dots Spontaneous Emission With Metamaterial Perfect Absorbers, Wei Wang, Xiaodong Yang, Ting S. Luk, Jie Gao Jan 2019

Enhanced Quantum Dots Spontaneous Emission With Metamaterial Perfect Absorbers, Wei Wang, Xiaodong Yang, Ting S. Luk, Jie Gao

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Metamaterial perfect absorbers (PAs) made of a hexagonal array of holes on Ag-SiO 2 -Ag thin films have been realized and utilized to enhance the spontaneous emission rate and photoluminescence intensity of CdSe/ZnS quantum dots (QDs) spin-coated on the absorber top surface. Perfect absorption of incoming light occurs at the wavelength where the impedance is matched to that of the free space. When QDs strongly excite both the electric and magnetic resonances at this perfect absorption wavelength, a significant Purcell effect on the spontaneous emission process and enhanced radiative outcoupling of photoluminescence intensity are expected. For perfect absorbers with near-unity …


Fabrication Of Alcocrfeni High-Entropy Alloy Coating On An Aisi 304 Substrate Via A Cofe₂Ni Intermediate Layer, Wenyuan Cui, Sreekar Karnati, Xinchang Zhang, Elizabeth Burns, Frank W. Liou Jan 2019

Fabrication Of Alcocrfeni High-Entropy Alloy Coating On An Aisi 304 Substrate Via A Cofe₂Ni Intermediate Layer, Wenyuan Cui, Sreekar Karnati, Xinchang Zhang, Elizabeth Burns, Frank W. Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Through laser metal deposition, attempts were made to coat AlCoCrFeNi, a high-entropy alloy (HEA), on an AISI 304 stainless steel substrate to integrate their properties. However, the direct coating of the AlCoCrFeNi HEA on the AISI 304 substrate was found to be unviable due to cracks at the interface between these two materials. The difference in compositional change was suspected to be the source of the cracks. Therefore, a new transition route was performed by coating an intermediate layer of CoFe2Ni on the AISI 304 substrate. Investigations into the microstructure, phase composition, elemental composition and Vickers hardness were …


Design And Implementation Of Periodic Unsteadiness Generator For Turbine Secondary Flow Studies, Nathan James Fletcher Jan 2019

Design And Implementation Of Periodic Unsteadiness Generator For Turbine Secondary Flow Studies, Nathan James Fletcher

Browse all Theses and Dissertations

A primary source of periodic unsteadiness in low-pressure turbines is the wakes shed from upstream blade rows due to the relative motion between adjacent stators and rotors. These periodic perturbations can affect boundary layer transition, secondary flow, and loss generation. In particular, for high-lift front-loaded blades, the secondary flowfield is characterized by strong three-dimensional vortical structures. It is important to understand how these flow features respond to periodic disturbances. A novel approach was taken to generate periodic unsteadiness which captures some of the physics of turbomachinery wakes. Using stationary pneumatic devices, pulsed jets were used to generate disturbances characterized by …


Scalable Clustering For Immune Repertoire Sequence Analysis, Prem Bhusal Jan 2019

Scalable Clustering For Immune Repertoire Sequence Analysis, Prem Bhusal

Browse all Theses and Dissertations

The development of the next-generation sequencing technology has enabled systems immunology researchers to conduct detailed immune repertoire analysis at the molecule level. Large sequence datasets (e.g., millions of sequences) are being collected to comprehensively understand how the immune system of a patient evolves over different stages of disease development. A recent study has shown that the hierarchical clustering (HC) algorithm gives the best results for B-cell clones analysis - an important type of immune repertoire sequencing (IR-Seq) analysis. However, due to the inherent complexity, the classical hierarchical clustering algorithm does not scale well to large sequence datasets. Surprisingly, no algorithms …