Engineering Commons^™

Effect Of Tcdd, An Environmental Contaminant, On Activation Of Ahr Leading To Induction Of Myeloid Derived Suppressor Cells (Mdscs) And The Ability Of Resveratrol, A Botanical, To Neutralize This Effect, Wurood Hantoosh Neamah

Theses and Dissertations

Aryl hydrocarbon receptor (AhR), is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control various cellular processes, such as the cell cycle, epithelial barrier function, cell migration and immune function. AhR was discovered as the receptor that binds with high affinity to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and leads to numerous of toxicological outcomes. In the current study, we discovered a critical role played by AhR, following activation by TCDD, in modulating a variety of immunological functions through regulation of epigenetic and microbial pathways. Our data demonstrated that AhR activation triggers MDSC mobilization from bone marrow to peritoneal …

Role Of Epigenetic, Molecular And Cellular Pathways In The Regulation Of Inflammation, William James Becker

Theses and Dissertations

Dysregulated inflammation is at the heart of countless human diseases. Graft rejection is the process by which an organ from an incompatible donor is rejected by the recipient whose immune cells attack the foreign tissue. Colitis is an inflammatory disorder caused by undue chronic inflammation in the colon and rectum that can progress to cancer. Colitis incidence is on the rise, especially in developing nations and Asia; and the list of patients who need organ transplants grow by the day. Therapies for both graft rejection and colitis are limited to immunosuppressive drugs that leaves patients vulnerable to infection, heart disease, …

Enhancing Thermal-Hydraulic Performance Of Parallel And Counter Flow Mini-Channel Heat Sinks Utilizing Secondary Flow: A Numerical And Experimental Study, Amitav Tikadar

Theses and Dissertations

Continual growth of hydraulic and thermal boundary layers along stream wise direction in conventional straight fin mini-channel heat sink causes gradual deterioration of their thermal performance. To enhance thermal-hydraulic performance by breaking and redevelopment of the boundary layers, this research aims to introduce a novel inter-connected mini-channel sinks. Two inter-connectors were positioned transversely between two adjacent mini-channels, which segmented the flow domain into three zones. Secondary flow was generated through the inter-connectors utilizing the pressure difference of the adjacent channels resulting in hydraulic and thermal boundary layers disruption and hence enhanced thermal-hydraulic performance of the mini-channel heat sink was achieved. …

Flame Spray Pyrolysis Of Ce-Mn Solid Solutions For Catalytic Applications, Nicole Cordonnier

Theses and Dissertations

Flame spray pyrolysis (FSP) is a method of quickly synthesizing active particles in a flame. Precursors are dissolved in a flammable organic solvent before being sprayed into the flame environment where they rapidly burn. Particle formation occurs on the order of 10 milliseconds. FSP has been shown to be a viable method of producing materials on an industrial scale, capable of producing grams of particles per minute. Metastable structures which exist in the liquid phase, but are difficult to synthesize using traditional impregnation methods can be formed with FSP due to fast quenching times. For example, solid solutions of Ce-Zr …

Epigenetic And Purinergic Regulation Of Mast Cells Mediator Release, Zahraa Abdulmohsin Mohammed

Theses and Dissertations

Mast cells (MCs) are well known for their implications in allergic reactions. They are also known to have multiple functions in the innate and adaptive immune system. Their activation plays an essential role in many aspects of physiological and pathological conditions. Allergies are considered chronic conditions that affect more than 60 million people in the U.S. These diseases are driven by the activation of MCs in response to IgE-mediated antigen, rendering these cells as targets for the management of allergies and asthma. Therefore, this research considers the understanding of their activation and the regulation of their response to be an …

Machine Learning Methods For Rapid Inspection Of Automated Fiber Placement Manufactured Composite Structures, Christopher Sacco

Theses and Dissertations

The advanced manufacturing capabilities provided through the automated fiber placement (AFP) system has allowed for faster layup time and more consistent production across a number of different geometries. This contributes to the modern production of large composite structures and the widespread adaptation of composites in industry in general and aerospace in particular. However, the automation introduced in this process increases the difficulty of quality assurance efforts and inspection. The AFP process can induce a number of manufacturing defects including wrinkles, twists, gaps, and overlaps. The manual identification of these defects is often laborious and requires a measure of expert knowledge. …

Experimental Methods And Techniques For Improved Biomechanical Characterization Of Diverse Murine Aortopathies, Brooks Alexander Lane

Theses and Dissertations

Aortopathies constitute a broad class of diseases affecting the aorta – the largest artery responsible for distributing oxygenated blood to the systemic circulation. Specifically, aortic aneurysms (AAs) are described as a focal dilation of the vascular wall exceeding 50% of the normal vessel diameter. Ultimately AAs may stabilize, dissect, or rupture, with the latter virtually ensuring mortality. Currently clinicians consider prophylactic intervention based on size and growth-rate criteria that have been estimated from large-cohort statistical analyses. These criteria, however, fail to address the underlying mechanisms. Furthermore, 13% of small-to-mid sized AAs have been found to rupture prior to meeting these …

Damage Evaluation Of Concrete Structures Using Acoustic Emission, Rafal Anay

Theses and Dissertations

The deterioration and aging of the infrastructure in the U.S. have become a crucial issue, especially for highway bridges and nuclear power plants. The reliability and safety of existing structures are affected by growing populations and limited resources. This issue has gained significant concern during the last two decades and efforts are being conducted to accelerate the improvement of nondestructive testing (NDT) and structural health monitoring (SHM) methods. Additional information regarding the condition of existing structures and the early detection of damage can aid in reducing overall maintenance costs. The studies presented in this dissertation employ acoustic emission (AE) as …

A Model For Condensation Heat Transfer In Hydrophobic-­Hydrophilic Surfaces, Abdulwahab E. Alhashem

Theses and Dissertations

The primary focus of this research is to provide a validated model for a comprehensive understanding of hydrophobic-­‐hydrophilic condensation on patterned-­‐ hybrid surface. Establishing the model requires the modeling of fully dropwise condensation (DWC) before applying modifications to evaluate heat transfer performance of patterned-­‐hybrid condensation surface.

The model for fully DWC consists of defining expressions for heat transfer through a single drop, maximum radius of the drop and drop-­‐size distribution which all are primarily based on the work in the literature. In this work the author utilized a proposed modified version of the simulation for drop-­‐size distribution for fully DWC, …

Health Monitoring Of Liquid Pipelines, Mohammed Hameed Sabhan Al-Tofan

Theses and Dissertations

The crude and refined oil, water, and other liquids are widely transported through pipelines over long distances within geographical boundaries of countries or beyond. Pipeline accidents, however, are frequent, affecting operation and reducing targeted performance. The frequency of these accidents presents a growing concern and necessitates the need for an effective health monitoring plan. This plan requires monitoring of flow conditions and warning of any changes or abnormal conditions. Abnormalities in the flow conditions include changes in the piping system performance due to defects, such as leaks and blockages. These changes can be located and quantified utilizing different approaches. Two …

Proactive Energy Optimization In Residential Buildings With Weather And Market Forecasts, Cody Ryan Simmons

Theses and Dissertations

This work explores the development of a home energy management system (HEMS) that uses weather and market forecasts to optimize the usage of home appliances and to manage battery usage and solar power production. A Moving Horizon Estimation (MHE) application is used to find the unknown home model parameters. These parameters are then updated in a Model Predictive Controller (MPC) which optimizes and balances competing comfort and economic objectives. Combining MHE and MPC applications alleviates model complexity commonly seen in HEMS by using a lumped parameter model that is adapted to fit a high-fidelity model. HVAC on/off behaviors are simulated …

Physico-Chemical Characteristics Of Ethanol–Diesel Blend Fuel, Tarek M. Aboul-Fotouh, Eslam Alaa, M. A. Sadek, Hany A. Elazab

Chemical and Biochemical Engineering Faculty Research & Creative Works

In this research we are discussing the physicochemical characteristics of sweet diesel after desulphurization alone and also these characteristics are tested with the adding of high purity HPLC ethanol (99.9%). Those fuel properties of ethanol blended with diesel were experimentally determined to find their stability and to increase their properties and efficiency in the diesel engines. First, we made 4 blends of diesel with ethanol and the fifth sample was pure diesel. The samples were 0% ethanol and 100 % diesel, the second sample was 5% ethanol and 95 % diesel, the third sample was 10 % ethanol and 90% …

Advanced Measurement Techniques For Enabling Multiphase Reactors And Flow Systems For Sustainable And Cleaner Processes, Muthanna H. Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

No abstract provided.

Application And Evaluation Of Full-Field Surrogate Models In Engineering Design Space Exploration, Christopher Murray Thelin

Theses and Dissertations

When designing an engineering part, better decisions are made by exploring the entire space of design variations. This design space exploration (DSE) may be accomplished manually or via optimization. In engineering, evaluating a design during DSE often consists of running expensive simulations, such as finite element analysis (FEA) in order to understand the structural response to design changes. The computational cost of these simulations can make thorough DSE infeasible, and only a relatively small subset of the designs are explored. Surrogate models have been used to make cheap predictions of certain simulation results. Commonly, these models only predict single values …

Periodic Orbit Analytic Construction In The Circular Restricted Three-Body Problem, Jay Shriram Suryawanshi

Mechanical & Aerospace Engineering Theses & Dissertations

This thesis investigates an approximate analytic construction of halo-type periodic orbits about the collinear equilibrium points in the circular restricted three-body problem. The research follows a parallel approach to the one used by Ghazy and Newman, but the initial assumptions and utilized functions are unique to this thesis. A suppositional base solution constructed using Jacobi elliptic functions and satisfying Jacobi's integral equation is at the core of the analytic construction framework. The locus of this solution is a circle lying in the plane perpendicular to the line joining the primaries. The base solution elicits a closed-form expression for the period …

Nuclear Engineering At The Air Force Institute Of Technology: A Unique Graduate School Experience For A Unique Set Of Students, Michael B. Shattan

Faculty Publications

In August 2018, the Air University Commander formed a task force to review the Air Force’s Science, Technology, Engineering, and Mathematics (STEM) graduate education programs that are delivered and administered through the Air Force Institute of Technology (AFIT). The study was rooted in strategies to support the 2018 National Defense Strategy, and provided the necessary technologically equipped personnel for the 21st century. The study was commonly referred to as “reimagining AFIT”. Several themes emerged from the study, which include reaching a broader community of Airmen through alternate educational modes (e.g. distance learning, short course etc.), forming strategic educational and research …

The Resilient City: A Platform For Informed Decision-Making Process, Jarutpong Vasuthanasub

Engineering Management & Systems Engineering Theses & Dissertations

As over half of the world’s population lives in cities, the rapid growth in urbanization has made cities become more and more exposed and vulnerable to a broad spectrum of threats and hazards. In order to respond to such difficulties, a concept of resilience is considered a significant component for the long-term planning and sustainable development of cities. “Resilient City” is a new paradigm that challenges the idealistic principle of stability and resistance to change implicitly in sustainable development and long-term success. However, building a resilient city requires a holistic approach, as well as the appropriate adoption of knowledge and …

Reducing The Noise Impact Of Unmanned Aerial Vehicles By Flight Control System Augmentation, Matthew B. Galles

Mechanical & Aerospace Engineering Theses & Dissertations

The aim of this thesis is to explore methods to reduce the noise impact of unmanned aerial vehicles operating within acoustically sensitive environments by flight control system augmentation. Two methods are investigated and include: (i) reduction of sound generated by vehicle speed control while flying along a nominal path and (ii) reduction of acoustic exposure by vehicle path control while flying at a nominal speed. Both methods require incorporation of an acoustic model into the flight control system as an additional control objective and an acoustic metric to characterize primary noise sources dependent on vehicle state. An acoustic model was …

Using Feature Extraction From Deep Convolutional Neural Networks For Pathological Image Analysis And Its Visual Interpretability, Wei-Wen Hsu

Electrical & Computer Engineering Theses & Dissertations

This dissertation presents a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification from the convolutional neural networks (CNN) are demonstrated in this study to provide comprehensive interpretability for the proposed CAD system using the domain knowledge in pathology. In the experiment, a total of 186 slides of WSIs were collected and classified into three categories: Non-Carcinoma, Ductal Carcinoma in Situ (DCIS), and Invasive Ductal Carcinoma (IDC). Instead of conducting pixel-wise classification (segmentation) into three classes directly, a hierarchical framework with the …

Unsupervised-Learning Assisted Artificial Neural Network For Optimization, Varun Kote

Mechanical & Aerospace Engineering Theses & Dissertations

Innovations in computer technology made way for Computational Fluid Dynamics (CFD) into engineering, which supported the development of new designs by reducing the cost and time by lowering the dependency on experimentation. There is a further need to make the process of development more efficient. One such technology is Artificial Intelligence. In this thesis, we explore the application of Artificial Intelligence (AI) in CFD and how it can improve the process of development.

AI is used as a buzz word for the mechanism which can learn by itself and make the decision accordingly. Machine learning (ML) is a subset of …

Deep Reinforcement Learning Approach For Lagrangian Control: Improving Freeway Bottleneck Throughput Via Variable Speed Limit, Reza Vatani Nezafat

Civil & Environmental Engineering Theses & Dissertations

Connected vehicles (CVs) will enable new applications to improve traffic flow. The focus of this dissertation is to investigate how reinforcement learning (RL) control for the variable speed limit (VSL) through CVs can be generalized to improve traffic flow at different freeway bottlenecks. Three different bottlenecks are investigated: A sag curve, where the gradient changes from negative to positive values causes a reduction in the roadway capacity and congestion; a lane reduction, where three lanes merge to two lanes and cause congestion, and finally, an on-ramp, where increase in demand on a multilane freeway causes capacity drop. An RL algorithm …

Performance Of Cognitive Radio Networks With Unknown Dynamic Primary User Signals, Sara L. Macdonald

Electrical & Computer Engineering Theses & Dissertations

The current static assignment of RF spectrum in the United States and other parts of the world has led to a large portion of the RF spectrum to be geographically and temporally underutilized. While the amount of RF spectrum is finite, the demand for spectrum continues to increase making it necessary to increase utilization of many bands. Several innovative methods for allowing licensed primary users (PUs) to share spectrum with unlicensed secondary users (SUs) have being proposed. Of these methods Cognitive Radio (CR) has emerged as a promising technology that enables SUs to dynamically access spectrum after first sensing the …

A Design Of Inductive Coupling Wireless Power Transfer System For Electric Vehicle Applications, Sarika Reddy Daida

Electrical & Computer Engineering Theses & Dissertations

This research focuses on the study of using an inductive-coupled Wireless Power Transfer (WPT) system for electric vehicle charging applications in Medium Voltage DC (MVDC) power networks. Implementing WPT in Electric Vehicles (EVs) can provide a convenient alternative charging option, versus static charging in a station that would take hours. Also, it can prevent the potential of electrocution hazards that might occur due to the usage of physical medium like wires in EV charging. Even though inductive coupling has been applied in some applications of WPT, it is still not efficient enough to transfer high power at the kilowatts level …

Endogenous Force Transmission Between Epithelial Cells And A Role For Α-Catenin, Sandeep Dumbali

Mechanical & Aerospace Engineering Theses & Dissertations

In epithelial tissues, epithelial cells adhere to each other as well as to the underlying extra-cellular matrix (ECM). E-cadherin-based intercellular junctions play an important role in tissue integrity. These junctions experience cell-generated mechanical forces via apparent adaptor proteins such as beta (β) catenin, alpha (α) catenin and vinculin. Abnormalities in these junctions may result in skin related diseases and cancers. Here, I devised methods to determine the endogenous intercellular force within cell pairs as well as in large epithelial islands. I further ascertained the factors that affect the level of inter-cellular tension.

Experiments with pairs of epithelial cells exogenously expressing …

Developing Algorithms To Detect Incidents On Freeways From Loop Detector And Vehicle Re-Identification Data, Biraj Adhikari

Civil & Environmental Engineering Theses & Dissertations

A new approach for testing incident detection algorithms has been developed and is presented in this thesis. Two new algorithms were developed and tested taking California #7, which is the most widely used algorithm to date, and SVM (Support Vector Machine), which is considered one of the best performing classifiers, as the baseline for comparisons. Algorithm #B in this study uses data from Vehicle Re-Identification whereas the other three algorithms (California #7, SVM and Algorithm #A) use data from a double loop detector for detection of an incident. A microscopic traffic simulator is used for modeling three types of incident …

Computational Analysis And Design Optimization Of Convective Pcr Devices, Jung Il Shu

Mechanical & Aerospace Engineering Theses & Dissertations

Polymerase Chain Reaction (PCR) is a relatively novel technique to amplify a few copies of DNA to a detectable level. PCR has already become common in biomedical research, criminal forensics, molecular archaeology, and so on. Many have attempted to develop PCR devices in numerous types for the purpose of the lab-on-chip (LOC) or point-of-care (POC). To use PCR devices for POC lab testing, the price must be lower, and the performance should be comparable to the lab devices. For current practices with the existing methods, the price is pushed up higher partially due to too much dependence on numerous developmental …

First Approach To Coupling Of Numerical Lifting-Line Theory And Linear Covariance Analysis For Uav State Uncertainty Propagation, Cory D. Goates, Randall S. Christensen, Robert C. Leishman

Faculty Publications

Numerical lifting-line is a computationally efficient method for calculating aerodynamic forces and moments on aircraft. However, its potential has yet to be tapped for use in guidance, navigation, and control (GN&C). Linear covariance analysis is becoming a popular GN&C design tool and shows promise for pairing with numerical lifting-line. Pairing numerical lifting-line with linear covariance analysis allows for forward propagation of state uncertainty for real-time decision making. We demonstrate this for select state variables in a drone aerial recapture situation. Linear covariance analysis uses finite difference derivatives obtained from numerical lifting-line to calculate force and moment variances. These show agreement …

The Potentiality Of Space Enterprise Force Reconstitution: Nationalizing Civilian Satellites During Kinetic Conflicts, Robert A. Bettinger, Sara Schmitt

Faculty Publications

This article will discuss the possibility of employing a policy of civilian satellite nationalization during a space war as a means of US Space Enterprise force re- constitution to ensure continued access to space capabilities necessary for the execution of the national strategy, as well as deterring potential adversaries from initiating counterspace hostilities. In terms of structure, the authors will examine the thesis by answering these questions. First, what historical precedent exists for the rapid military acquisition of civilian assets via nationalization? Second (given the unique nature of space as an operational environment), can that historical precedent be applied to …

M2 Factor Of A Vector Schell-Model Beam, Milo W. Hyde Iv, Mark F. Spencer

Faculty Publications

Extending existing scalar Schell-model source work, we derive the M² factor for a general electromagnetic or vector Schell-model source to assess beam quality. In particular, we compute the M² factors for two vector Schell-model sources found in the literature. We then describe how to synthesize vector Schell-model beams in terms of specified, desired M² and present Monte Carlo simulation results to validate our analysis.

Exact Analytical Formula For The Excess Noise Factor For Mixed Carrier Injection Avalanche Photodiodes, Md. Mottaleb Hossain, John P.R. David, Majeed M. Hayat

Electrical and Computer Engineering Faculty Research and Publications

The well-known analytical formula for the excess noise factor associated with avalanche photodiodes (APDs), developed by R. J. McIntyre in 1966, assumes the injection of either an electron or a hole at the edge of the APD's avalanche region. This formula is based on the statistics of the probabilities of carriers gaining and losing energy subject to high electric fields. However, this analytical formula, is not applicable in cases when photons are absorbed inside the avalanche region (even though the physics of the high field transport remains the same), and its use may severely underestimate or overestimate the actual excess …