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Articles 52471 - 52500 of 197098
Full-Text Articles in Engineering
Sustainability Key Performance Indicators For Mass Customization, Md Fahid Hasan Pulak
Sustainability Key Performance Indicators For Mass Customization, Md Fahid Hasan Pulak
Graduate Theses, Dissertations, and Problem Reports (ETD)
Today’s manufacturers are striving towards a more sustainable and customized product offering in their value chain to satisfy customer demand and compete on the marketplace. By adopting sustainability practices, companies are not only complying with environmental regulations but are strategically addressing the triple bottom line (TBL) of sustainability (environmental, social, and economic). Similarly, mass customization allows a company to better satisfy their customers by creating individualized products economically. Moving forward, it is important to better understand the relationship of these two competitive strategies. In order to assess the sustainability performance of mass customization, it is important to understand the appropriate …
Evaluating Social Media As A Medium Of Private Communication Through Steganographic Images, Kendall Weldon Coles
Evaluating Social Media As A Medium Of Private Communication Through Steganographic Images, Kendall Weldon Coles
Graduate Theses, Dissertations, and Problem Reports (ETD)
Social media is a vastly used communication tool with billions of users worldwide. These social networks provide users the ability to share their ideas and thoughts through the messages, videos, and images that they post. The images that are shared can possibly be embedded with private messages through the use of a steganographic tool. The messages are embedded in a fashion that doesn’t change the visual appearance of an image. This allows for these types of images to hide in plain sight, which creates the possibility of someone communicating privately in a public social media setting. This project proved how …
Iot Malicious Traffic Classification Using Machine Learning, Michael Austin
Iot Malicious Traffic Classification Using Machine Learning, Michael Austin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Although desktops and laptops have historically composed the bulk of botnet nodes, Internet of Things (IoT) devices have become more recent targets. Lightbulbs, outdoor cameras, watches, and many other small items are connected to WiFi and each other; and few have well-developed security or hardening. Research on botnets typically leverages honeypots, PCAPs, and network traffic analysis tools to develop detection models. The research questions addressed in this Problem Report are: (1) What machine learning algorithm performs the best in a binary classification task for a representative dataset of malicious and benign IoT traffic; and (2) What features have the most …
Development Of Collision Resilient Drone For Flying In Cluttered Environment, Al Mahmud
Development Of Collision Resilient Drone For Flying In Cluttered Environment, Al Mahmud
Graduate Theses, Dissertations, and Problem Reports (ETD)
The use of multi-rotor aerial vehicles, also known as drones, has increased significantly in the last decade due to their ease of use and applicability to an extended range of functions. Therefore, the importance of making these vehicles safe, for both themselves and the people around them, has also increased. A clear solution to this problem is the development of algorithms that generate collision-free paths using different sensors. However, even with such onboard computation, avoiding a collision is not always possible. Thus, the use of a protective structure (cage) around the aerial vehicle is a solution to keep it safe …
Deep Models For Improving The Performance And Reliability Of Person Recognition, Sobhan Soleymani
Deep Models For Improving The Performance And Reliability Of Person Recognition, Sobhan Soleymani
Graduate Theses, Dissertations, and Problem Reports (ETD)
Deep models have provided high accuracy for different applications such as person recognition, image segmentation, image captioning, scene description, and action recognition. In this dissertation, we study the deep learning models and their application in improving the performance and reliability of person recognition. This dissertation focuses on five aspects of person recognition: (1) multimodal person recognition, (2) quality-aware multi-sample person recognition, (3) text-independent speaker verification, (4) adversarial iris examples, and (5) morphed face images. First, we discuss the application of multimodal networks consisting of face, iris, fingerprint, and speech modalities in person recognition. We propose multi-stream convolutional neural network architectures …
Application Of 3d Seismic Signal And Geomechanical Attributes For Subsurface Fracture Characterization: A Case Study In Clearfield County, Central Pennsylvania, Iman F. Zulkapeli
Application Of 3d Seismic Signal And Geomechanical Attributes For Subsurface Fracture Characterization: A Case Study In Clearfield County, Central Pennsylvania, Iman F. Zulkapeli
Graduate Theses, Dissertations, and Problem Reports (ETD)
Hydrocarbon exploration in unconventional reservoirs is highly risky due to the nature of the reservoirs and the variability in fractures and reservoir geomechanical properties in the subsurface. The reservoir needs to be fully characterized to avoid any complication such as frac hit, wellbore failure, blowout, or even a dry hole. The Clearfield reservoir produces an exceptionally low amount of gas, compared to the neighboring region in the proximity, which has been poorly understood. This raises the question as to what causes the reservoir to have low productivity.
This study focuses on the natural fracture characterization using high-quality 3D seismic signal …
Real Vs Fake Faces: Deepfakes And Face Morphing, Jacob L. Dameron
Real Vs Fake Faces: Deepfakes And Face Morphing, Jacob L. Dameron
Graduate Theses, Dissertations, and Problem Reports (ETD)
The ability to determine the legitimacy of a person’s face in images and video can be important for many applications ranging from social media to border security. From a biometrics perspective, altering one’s appearance to look like a target identity is a direct method of attack against the security of facial recognition systems. Defending against such attacks requires the ability to recognize them as a separate identity from their target. Alternatively, a forensics perspective may view this as a forgery of digital media. Detecting such forgeries requires the ability to detect artifacts not commonly seen in genuine media. This work …
Increasing The Reliability Of Software Systems On Small Satellites Using Software-Based Simulation Of The Embedded System, Matthew D. Grubb
Increasing The Reliability Of Software Systems On Small Satellites Using Software-Based Simulation Of The Embedded System, Matthew D. Grubb
Graduate Theses, Dissertations, and Problem Reports (ETD)
The utility of Small Satellites (SmallSats) for technology demonstrations and scientific research has been proven over the past few decades by governments, universities, and private companies. While the research and technology demonstration objectives that can be provided by these SmallSats are becoming similar to larger spacecraft, their reliability still falls behind. This is in part due to the reduced cost of SmallSat missions in comparison to large spacecraft, which requires cheaper components, rapid development schedules, and accepted risk. In these missions, the importance of the flight software is often overlooked, and the software is rushed through development and not fully …
Erosion And Sediment Controls On Reclaimed Mine Refuse Impoundments, Sara Dalen
Erosion And Sediment Controls On Reclaimed Mine Refuse Impoundments, Sara Dalen
Graduate Theses, Dissertations, and Problem Reports (ETD)
To ensure the sustainable use of one of West Virginia’s precious resources, conscientious long-term management of residual waste is of immense importance. This thesis examined two main topics: i) the dewatering process of acid mine drainage (AMD) sludge, and ii) an investigation of soil loss predictions of a reclaimed coal refuse impoundment.
The first aspect of this thesis addresses clarification and remediation of AMD prior to disposal is a prominent component to preventing runoff and seepage of environmentally detrimental byproducts. To examine the effects of flocculation and dewatering more closely by means of geotextiles, an AMD sludge was analyzed. The …
Multimodel Operability Framework For Design Of Modular And Intensified Energy Systems, Vitor Gazzaneo
Multimodel Operability Framework For Design Of Modular And Intensified Energy Systems, Vitor Gazzaneo
Graduate Theses, Dissertations, and Problem Reports (ETD)
In this dissertation, a novel operability framework is introduced for the process design of modular and intensified energy systems that are challenged by complexity and highly constrained environments. Previously developed process operability approaches are reviewed and further developed in terms of theory, application, and software infrastructure. An optimization-based multilayer operability framework is introduced for process design of nonlinear energy systems. In the first layer of this framework, a mixed-integer linear programming (MILP)-based iterative algorithm considers the minimization of footprint and achievement of process intensification targets. Then, in the second layer, an operability analysis is performed to incorporate key features of …
The Role Of Structure Evolution For Prbaco2o6-Δ In Oxygen Reduction Reaction Kinetics At Sofc Cathode, Nan Zhang
Graduate Theses, Dissertations, and Problem Reports (ETD)
Mixed ion and electron conductive materials especially those with perovskite-related structures have been widely used as cathode and anode of solid oxide fuel cells (SOFC). Double perovskite LnBaCo2O6-δ (Ln=Pr, Nd, Sm, Nd, Y) cathodes have been shown better performance than single perovskite Ln0.5Ba0.5CoO3-δ in SOFC cathode studies. However, the effect of different double perovskite phases on oxygen transport properties has not been investigated. In this study, the electrochemical performance of different double perovskite materials PrBaCo2O6-δ (PBCO), NdBaCo2O6-δ (NBCO), YBaCo2O6-δ (YBCO), and single perovskite …
Touching Light: A Framework For The Facilitation Of Music-Making In Mixed Reality, Ian Thomas Riley
Touching Light: A Framework For The Facilitation Of Music-Making In Mixed Reality, Ian Thomas Riley
Graduate Theses, Dissertations, and Problem Reports (ETD)
Drawing upon the historical development of analog and digital technologies alongside the proliferation of computer-assisted performance practices, this research seeks to develop a framework for integrating Mixed Reality applications to live musical performance, specifically through the creation of a Microsoft HoloLens 2 Mixed Reality application in order to facilitate a live performance of an original musical composition for percussion and real-time Mixed Reality environment. Mixed Reality enables a performer to interact with virtual (holograms, VSTs, etc.) and physical (vibraphone, tuned drums, microphones, etc.) objects simultaneously. Tandem to the development of the conceptual framework was the composition of an original score …
Bibliometric Analysis Of Research Trends In Rice Straw/Husk Reinforced Polymer Composites, Deepak D Dr., Abhishek S. Madival, Anupkumar M. Bongale Dr.
Bibliometric Analysis Of Research Trends In Rice Straw/Husk Reinforced Polymer Composites, Deepak D Dr., Abhishek S. Madival, Anupkumar M. Bongale Dr.
Library Philosophy and Practice (e-journal)
Bibliometric research is statistical analysis of publications to identify the most influencing sources of research pertaining to a specific area of research. This paper presents an overview research on rice straw/husk (RS/RH) reinforced polymer composites by using the bibliometric indicators to establish the research framework and to identify the essential research. The relevant journals, authors, institutions and countries which have significantly contributed to research on RS/RH based composite is focused. The bibliometric data is generated through Scopus database. It is observed that the number of publications on characterization of RS/RH based composites are consistently increasing over the last few years …
Hr Process Automation: A Bibliometric Analysis, Shubham Mishra, Monica Kunte, Netra Neelam, Sanjay Bhattacharya, Preeti Mulay
Hr Process Automation: A Bibliometric Analysis, Shubham Mishra, Monica Kunte, Netra Neelam, Sanjay Bhattacharya, Preeti Mulay
Library Philosophy and Practice (e-journal)
Automation is interpreted as the replacement of manual operations by electronics and computer-controlled systems. Human resource management is an indispensable part of every firm be it the space of retail, healthcare, education or any other sector. Activities such as hiring new workers, training, or making sure that local labour laws are obeyed with HR processes and are a crucial part of every organisation. HR has typically been believed of as an extremely manual department procedure. Employees are accustomed to doing this manually and getting the job done themselves. But everything around the HR processes are changing rapidly. HR Automation is …
Bibliometric Review On Applications Of Disease Detection Using Digital Image Processing Techniques, Jayant Jagtap, Rahil Sharma, Aryan Sinha, Nikhil Panda, Amulya Reddy
Bibliometric Review On Applications Of Disease Detection Using Digital Image Processing Techniques, Jayant Jagtap, Rahil Sharma, Aryan Sinha, Nikhil Panda, Amulya Reddy
Library Philosophy and Practice (e-journal)
Advances around the field of deep learning and cognitive computing have allowed mankind to look and solve the problems of the world in a completely new way. Deep learning has been making huge advancements in the field of healthcare, which most importantly focuses upon disease detection and disease prediction. Techniques such as these have been conceptualized the idea of early detection and economical ways of treating the predicted disease in particular. Still, it has been observed that there seems to be no change in the way diagnosis of a particular disease takes place even in the 21st generation of …
Bibliometric Review On Image Based Plant Phenotyping, Shrikrishna Ulhas Kolhar, Jayant Jagtap
Bibliometric Review On Image Based Plant Phenotyping, Shrikrishna Ulhas Kolhar, Jayant Jagtap
Library Philosophy and Practice (e-journal)
Plant phenotyping is a quantitative description of structural, physiological and temporal traits of plants resulting from interaction of plant genotypes with the environment. A rapid development is in progress in the field of image-based plant phenotyping. Plant phenotyping has wide range of applications in plant breeding research, plant growth prediction, biotic and abiotic stress analysis, crop management and early disease detection. The main motive is to provide detailed bibliometric review in order to know the available literature and current research trends in the area of plant phenotyping using plant images. The bibliometric analysis is primarily based on Scopus, web of …
Quantum Clustering Drives Innovations: A Bibliometric And Patentometric Analysis, Shradha Deshmukh, Preeti Mulay
Quantum Clustering Drives Innovations: A Bibliometric And Patentometric Analysis, Shradha Deshmukh, Preeti Mulay
Library Philosophy and Practice (e-journal)
The paper presents a bibliometric analysis from 2014 to 2020 of the emerging and engaging field of quantum computing called Quantum Machine Learning (QML). The study discusses the analysis results from the comprehensive high indexed databases worldwide such as Institute of Electrical and Electronics Engineers (IEEE), Scopus, Web of Science (WOS), Google Scholar and the Association for Computing Machinery (ACM). Tools like iMapbuilder, IBM and SPSS Statistics are used to provide meaningful insights and flawless representations of the extracted data. There has been little research to provide a macroscopic overview of renowned authors, subject areas, funding agencies and patent applications …
Impact Of Neutron Energy On Asteroid Deflection Performance, Lansing S. Horan Iv, Darren E. Holland, Megan Bruck Syal, James E. Bevins, Joseph W. Wasem
Impact Of Neutron Energy On Asteroid Deflection Performance, Lansing S. Horan Iv, Darren E. Holland, Megan Bruck Syal, James E. Bevins, Joseph W. Wasem
Faculty Publications
In the future, a hazardous asteroid will find itself on a collision course with Earth. For asteroids of moderate size or larger, a nuclear device is one of humanity's only technologies capable of mitigating this threat via deflection on a timescale of less than a decade. This work examined how the output neutron energy from a nuclear device standoff detonation affects the deflection of a notional asteroid that is 300 meters in diameter and composed of silicon dioxide at a bulk density of 1.855 g/cm3. 14.1 MeV and 1 MeV neutron energy sources were modeled in MCNP to …
Resilience For Multi-Filter All-Source Navigation Framework With Integrity, Jonathon S. Gipson, Robert C. Leishman
Resilience For Multi-Filter All-Source Navigation Framework With Integrity, Jonathon S. Gipson, Robert C. Leishman
Faculty Publications
The Autonomous and Resilient Management of All-source Sensors (ARMAS) framework monitors residual-space test statistics across unique sensor-exclusion banks of filters, (known as subfilters) to provide a resilient, fault-resistant all-source navigation architecture with assurance. A critical assumption of this architecture, demonstrated in this paper, is fully overlapping state observability across all subfilters. All-source sensors, particularly those that only provide partial state information (altimeters, TDoA, AOB, etc.) do not intrinsically meet this requirement.
This paper presents a novel method to monitor real-time overlapping position state observability and introduces an "observability bank" within the ARMAS framework, known as Stable Observability Monitoring (SOM). SOM …
Understanding Flow Characteristics In Metal Additive Manufacturing, Carl R. Hartsfield, Travis E. Shelton, Gregory R. Cobb, Ryan A. Kemnitz, Joseph Weber
Understanding Flow Characteristics In Metal Additive Manufacturing, Carl R. Hartsfield, Travis E. Shelton, Gregory R. Cobb, Ryan A. Kemnitz, Joseph Weber
Faculty Publications
In fluid flow, the frictional effects from interior surfaces of flow components create pressure loss across the surface. Understanding this inherent pressure loss due to friction and other phenomena is important when designing a flow system. For conventional manufacturing, friction loss has been empirically studied and is well known in the engineering community. However, newer manufacturing techniques, such as laser powder bed fusion (LPBF), an additive manufacturing technique, need to be understood. The inherent flow conditions resulting from the additive processes were studied. Test samples were printed with the flow path oriented in the vertical direction with different channel diameters …
Intermittent Theta Burst Stimulation: Application To Spinal Cord Injury Rehabilitation And Computational Modeling, Neil Mittal
Intermittent Theta Burst Stimulation: Application To Spinal Cord Injury Rehabilitation And Computational Modeling, Neil Mittal
Theses and Dissertations
Loss of motor function from spinal cord injuries (SCI) results in loss of independence. Rehabilitation efforts are targeted to enhance the ability to perform activities of daily living (ADLs), but outcomes from physical therapy alone are often insufficient. Neuromodulation techniques that induce neuroplasticity may push the limits on recovery. Neuromodulation by intermittent theta burst transcranial magnetic stimulation (iTBS) induces neuroplasticity by increasing corticomotor excitability, though this has most frequently been studied with motor targets and on individuals not in need of rehabilitation. Increased corticomotor excitability is associated with motor learning. The response to iTBS, however, is highly variable and unpredictable, …
Agile Software Development: Creating A Cost Of Delay Framework For Air Force Software Factories, J. Goljan, Jonathan D. Ritschel, Scott Drylie, Edward D. White
Agile Software Development: Creating A Cost Of Delay Framework For Air Force Software Factories, J. Goljan, Jonathan D. Ritschel, Scott Drylie, Edward D. White
Faculty Publications
The Air Force software development environment is experiencing a paradigm shift. The 2019 Defense Innovation Board concluded that speed and cycle time must become the most important software metrics if the US military is to maintain its advantage over adversaries.1 This article proposes utilizing a cost-of-delay (CoD) framework to prioritize projects toward optimizing readiness. Cost-of-delay is defined as the economic impact resulting from a delaying product delivery or, said another way, opportunity cost. In principle, CoD assesses the negative impacts resulting from changes to the priority of a project.
Quantifying The Effects Of Aircraft Engine Upgrades On Operating And Support Costs, Bradford A. Myers, Edward D. White, Jonathan D. Ritschel, R. David Fass
Quantifying The Effects Of Aircraft Engine Upgrades On Operating And Support Costs, Bradford A. Myers, Edward D. White, Jonathan D. Ritschel, R. David Fass
Faculty Publications
For fixed wing aircraft within the U.S. Air Force, Operating and Support (O&S) costs encompass a large portion of total life cycle costs. O&S costs include fuel, maintenance, and engine upgrades. To the authors’ knowledge, no study to date has attempted to empirically quantify the realized effects of new aircraft engines on sustainment costs. Utilizing the Air Force Total Ownership Cost database, they focused on new engines appearing on the C-5s, C-130s, and C-135s. Although narrow in scope, results suggest newer engines have lower fuel costs. Maintenance costs for newer engines were not consistently higher or lower than the engines …
Integrating Cost As A Decision Variable In Wargames, Joshua N. Reese, Jonathan D. Ritschel, Brent T. Langhals, Ryan D. Engle
Integrating Cost As A Decision Variable In Wargames, Joshua N. Reese, Jonathan D. Ritschel, Brent T. Langhals, Ryan D. Engle
Faculty Publications
The US military can no longer afford to be reactive, leaving critical cost analyses to the months and years following operations or full-scale conflicts. By leveraging cost in wargaming as part of the Joint planning process, DOD can provide Congress and the American taxpayers a range of potential costs associated with various military engagements that reflect fiscal and operational realities.
Evaluation Of Spinal Anatomy Segmentation Methods Using Synthetic Computed Tomography Volumes, Austin Tapp, Michel Audette
Evaluation Of Spinal Anatomy Segmentation Methods Using Synthetic Computed Tomography Volumes, Austin Tapp, Michel Audette
Electrical & Computer Engineering Faculty Publications
Severe adolescent idiopathic scoliosis (AIS) is corrected by surgical procedures that necessitate ligament releases. To determine appropriate release allotments, soft tissues must be localized on a patient-specific basis, However, routine computer tomography (CT) imaging precludes traditional, voxel-based soft tissue localization. Fortunately, recent studies have proposed top-down segmentation methods, which elucidate soft tissues using pre-operative CT volumes. While the accuracy of vertebral segmentations obtained from these methods has not been determined, the accuracy of soft tissue segmentations has not. To ensure the soft tissue segmentation methods are clinically applicable, soft tissue validation must occur. This study presents an evaluation measure for …
Generation Of Excited Species In A Streamer Discharge, Shirshak K. Dhali
Generation Of Excited Species In A Streamer Discharge, Shirshak K. Dhali
Electrical & Computer Engineering Faculty Publications
At or near atmospheric pressure, most transient discharges, particularly in molecular gases or gas mixture containing molecular gases, result in a space charge dominated transport called a streamer discharge. The excited species generation in such discharges forms the basis for plasma chemistry in most technological applications. In this paper, we simulate the propagation of streamers in atmospheric pressure N2 to understand the energy partitioning in the formation of various excited species and compare the results to a uniform Townsend discharge. The model is fully two-dimensional with azimuthal symmetry. The results show a significantly larger fraction of the energy goes …
Monopolar Gene Electrotransfer Enhances Plasmid Dna Delivery To Skin, Anna Bulysheva, Loree Heller, Michael Francis, Frency Varghese, Carly Boye, Richard Heller
Monopolar Gene Electrotransfer Enhances Plasmid Dna Delivery To Skin, Anna Bulysheva, Loree Heller, Michael Francis, Frency Varghese, Carly Boye, Richard Heller
Electrical & Computer Engineering Faculty Publications
A novel monopolar electroporation system and methodologies were developed for in vivo electroporation intended for potential clinical applications such as gene therapy. We hypothesized that an asymmetric anode/cathode electrode applicator geometry could produce favorable electric fields for electroporation, without the typical drawback associated with traditional needle and parallel plate geometries. Three monopolar electrode applicator prototypes were built and tested for gene delivery of reporter genes to the skin in a guinea pig model. Gene expression was evaluated in terms of kinetics over time and expression distribution within the treatment site. Different pulsing parameters, including pulse amplitude, pulse duration, and pulse …
A Case Study: Influence Of Circuit Impedance On The Performance Of Class-E² Resonant Power Converter For Capacitive Wireless Power Transfer, Yashwanth Bezawada, Yucheng Zhang
A Case Study: Influence Of Circuit Impedance On The Performance Of Class-E² Resonant Power Converter For Capacitive Wireless Power Transfer, Yashwanth Bezawada, Yucheng Zhang
Electrical & Computer Engineering Faculty Publications
The evolution of power electronics led to rapid development in wireless charging technology; as a result, a single active switch topology was introduced. The present market utilizes inductive wireless power transfer (IPT); because of the disadvantages of cost, size, and safety concerns, research on wireless power transfer was diverted towards capacitive wireless power transfer (CPT). This paper studies the optimal impedance tracking of the capacitive wireless power transfer system for maximum power transfer. Compared to prior methods developed for maximum power point tracking in power control, this paper proposes a new approach by means of finding impedance characteristics of the …
Deep Neural Network Analysis Of Pathology Images With Integrated Molecular Data For Enhanced Glioma Classification And Grading, Linmin Pei, Karra A. Jones, Zeina A. Shboul, James Y. Chen, Khan M. Iftekharuddin
Deep Neural Network Analysis Of Pathology Images With Integrated Molecular Data For Enhanced Glioma Classification And Grading, Linmin Pei, Karra A. Jones, Zeina A. Shboul, James Y. Chen, Khan M. Iftekharuddin
Electrical & Computer Engineering Faculty Publications
Gliomas are primary brain tumors that originate from glial cells. Classification and grading of these tumors is critical to prognosis and treatment planning. The current criteria for glioma classification in central nervous system (CNS) was introduced by World Health Organization (WHO) in 2016. This criteria for glioma classification requires the integration of histology with genomics. In 2017, the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) was established to provide up-to-date recommendations for CNS tumor classification, which in turn the WHO is expected to adopt in its upcoming edition. In this work, we propose a novel …
Low-Temperature Gas Plasma Combined With Antibiotics For The Reduction Of Methicillin-Resistant Staphylococcus Aureus Biofilm Both In Vitro And In Vivo, Li Guo, Lu Yang, Yu Qi, Gulimire Niyazi, Jianbao Zheng, Ruobing Xu, Xusong Chen, Jingye Zhang, Wang Xi, Dingxin Liu, Xiaohua Wang, Hailan Chen, Michael G. Kong
Low-Temperature Gas Plasma Combined With Antibiotics For The Reduction Of Methicillin-Resistant Staphylococcus Aureus Biofilm Both In Vitro And In Vivo, Li Guo, Lu Yang, Yu Qi, Gulimire Niyazi, Jianbao Zheng, Ruobing Xu, Xusong Chen, Jingye Zhang, Wang Xi, Dingxin Liu, Xiaohua Wang, Hailan Chen, Michael G. Kong
Electrical & Computer Engineering Faculty Publications
Biofilm infections in wounds seriously delay the healing process, and methicillin-resistant Staphylococcus aureus is a major cause of wound infections. In addition to inactivating micro-organisms, low-temperature gas plasma can restore the sensitivity of pathogenic microbes to antibiotics. However, the combined treatment has not been applied to infectious diseases. In this study, low-temperature gas plasma treatment promoted the effects of different antibiotics on the reduction of S. aureus biofilms in vitro. Low-temperature gas plasma combined with rifampicin also effectively reduced the S. aureus cells in biofilms in the murine wound infection model. The blood and histochemical analysis demonstrated the biosafety of …