Engineering Commons^™

Sex-Related Differences In Murine Models Of Chemically Induced Pulmonary Fibrosis, Pavel Solopov, Ruben Manuel Luciano Colunga Biancatelli, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

We developed two models of chemically induced chronic lung injury and pulmonary fibrosis in mice (intratracheally administered hydrochloric acid (HCl) and intratracheally administered nitrogen mustard (NM)) and investigated male-female differences. Female mice exhibited higher 30-day survival and less weight loss than male mice. Thirty days after the instillation of either HCl or NM, bronchoalveolar lavage fluid displayed a persistent, mild inflammatory response, but with higher white blood cell numbers and total protein content in males vs. females. Furthermore, females exhibited less collagen deposition, milder pulmonary fibrosis, and lower Ashcroft scores. After instillation of either HCl or NM, all animals displayed …

Advanced Raman Spectroscopy Detection Of Oxidative Damage In Nucleic Acid Bases: Probing Chemical Changes And Intermolecular Interactions In Guanosine At Ultralow Concentration, Francesca Ripanti, Claudia Fasolato, Flavia Mazzarda, Simonetta Palleschi, Marina Ceccarini, Chunchun Li, Margherita Bignami, Enrico Bodo, Steven E.J. Bell, Filomena Mazzei, Paolo Postorino

Bioelectrics Publications

DNA/RNA synthesis precursors are especially vulnerable to damage induced by reactive oxygen species occurring following oxidative stress. Guanosine triphosphates are the prevalent oxidized nucleotides, which can be misincorporated during replication, leading to mutations and cell death. Here, we present a novel method based on micro-Raman spectroscopy, combined with ab initio calculations, for the identification, detection, and quantification of oxidized nucleotides at low concentration. We also show that the Raman signature in the terahertz spectral range (<100 >cm(-1)) contains information on the intermolecular assembly of guanine in tetrads, which allows us to further boost the oxidative damage detection limit. Eventually, we …

Age-Dependent Chronic Lung Injury And Pulmonary Fibrosis Following Single Exposure To Hydrochloric Acid, Ruben M.L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) represents a threat to public health. Children may inhale higher doses and develop greater injury because of their smaller airways and faster respiratory rate. We have developed a mouse model of pediatric exposure to HCl by intratracheally instilling p24 mice (mice 24 days old; 8–10 g) with 2 µL/g 0.1 N HCl, and compared the profile of lung injury to that in HCl-instilled adults (10 weeks old; 25–30 g) and their age-matched saline controls. After 30 days, alveolar inflammation was observed with increased proteinosis and mononuclear cells in the bronchoalveolar lavage fluid (BALF) in both …

Development Of Efficient Wide-Bandgap Perovskite Solar Cells With Composition And Interface Engineering, Khan Mamun Reza

Electronic Theses and Dissertations

Metal halide perovskites are considered the most promising solar energy technology because of their distinct properties, such as defect tolerance, low cost, easy fabrication due to solution-processibility, band tunability, etc. Due to these properties, the efficiency of perovskite solar cells reaches more than 25% and approaches the limit of singlejunction within last few years. To increase the efficiency further in a more cost-effective way, double junction tandem solar cells with an efficient ‘top’ wide-bandgap cell is desired. But wide-bandgap perovskites still face some critical issues, such as poor morphology, smaller grain size, the formation of excessive lead halides, light-induced halide …

Neural Network Based Occupancy Prediction Using Patterns Detected In Wifi Occupancy, Krishna Chaitanya Jagadeesh Simma, Thomas P. Caudell, Susan M. Bogus

Civil Engineering Faculty Publications

The role of occupants in building energy management is well established. Occupant information from commercial buildings can function as a metric for the heating, ventilation, and air conditioning (HVAC) loads. Predicting these loads ahead in time could aid in setting up HVAC protocols to minimize wasteful energy demand and improve occupant comfort. To this extent, several frameworks were proposed that use occupancy data collected from commercial office buildings and graduate student offices to predict occupancy. However, the occupancy data collected in these frameworks are controlled and have limited complexity compared to larger commercial spaces such as airports, libraries, lecture halls, …

Indeterminacy In Neutrosophic Theories And Their Applications, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

Indeterminacy makes the main distinction between fuzzy / intuitionistic fuzzy (and other extensions of fuzzy) set / logic vs. neutrosophic set / logic, and between classical probability and neutrosophic probability. Also, between classical statistics vs. neutrosophic and plithogenic statistics, between classical algebraic structures vs. neutrosophic algebrais structures, between crisp numbers vs. neutrosophic numbers. We present a broad definition of indeterminacy, various types of indeterminacies, and many practical applications.

Establishing Independent Tunability Of The Mechanical And Transport Properties Of Polymer Gels, Lucas Rankin

Master’s Theses

Polymer gels can be used in the fabrication of materials for filtering liquid and gaseous media, solid-state electrolytes, and transdermal medical patches. This diverse range of applications primarily relies on the transport and mechanical properties of polymer gels. Both sets of properties have shown excellent tunability, but typically in a coupled fashion. Establishing the independent tunability of the transport and mechanical properties of polymer gels (using simple, cost-effective methods) is paramount if polymer gels are to be used to their full potential. Specifically, block copolymer gels self-assemble into organized nanoscale networks within the gel solvent, which allows for facile control …

Study Of The Mechanlsm Of Flow-Induced Vibrations Of A Cylinder In Proximity To A Wall, Jonathan M. Chambers

Master’s Theses

Flexible bluff bodies exposed to a uniform fluid flow undergo vibration due to vortex-shedding from the body. This phenomenon is known as vortex-induced vibration (VIV). Structural members, such as cables, conduits, and pipes, are susceptible to VIV. Vortex-induced vibrations result in structural stresses due to elastic structural deformation from the flow-induced loading. Cylindrical structures in proximity to planar surfaces can undergo vortex-induced vibrations when the gap between the cylinder and the planar surfaces is above a critical value. This laboratory study investigated the mechanism of vibration and planar wall proximity effect on the cylinder response to the vortex shedding process. …

An Enumeration Of Nested Networks, Nathan Cornelius

Williams Honors College, Honors Research Projects

Nested networks have several applications in phylogenetics and electrical circuit theory. In many cases, there may exist more than one distinct network which correctly models a given data set. This proposes a combinatorial problem to determine all possible network solutions. In this paper, we partially solve this problem by developing exponential generating functions which enumerate all 1-nested and 2-nested unicyclic networks. We also describe our procedure to directly count all 1-nested and 2-nested networks and provide all 1-nested networks with 7, 8, and 9 terminal nodes.

The Characterization Of Purified Citrate-Coated Cerium Oxide Nanoparticles Prepared Via Hydrothermal Synthesis, Matthew L. Hancock, Robert A. Yokel, Matthew J. Beck, Julie L. Calahan, Travis W. Jarrells, Eric J. Munson, George A. Olaniyan, Eric A. Grulke

Chemical and Materials Engineering Faculty Publications

Hypothesis

Cerium oxide nanoparticles were synthesized using a hydrothermal approach with citric acid as a stabilizing agent. Citric acid adsorption onto the nanoceria particle surface can cease particle formation and create a stable dispersion for an extended shelf life. The product was dialyzed immediately following the synthesis to remove unreacted cerium that could contribute to biological effects. Nanoparticle characterization results are expected to help identify the surface citrate bonding structure.

Experiments

Many characterization techniques were utilized to determine size, morphology, surface properties, and citrate complexation on the nanoceria particle surface. These included transmission electron microscopy, electron energy loss spectroscopy, dynamic …

Leveraging Chemical And Computational Biology To Probe The Cellulose Synthase Complex, B. Kirtley Amos

Theses and Dissertations--Plant and Soil Sciences

Cellular expansion in plants is a complex process driven by the constraint of internal cellular turgor pressure by an expansible cell wall. The main structural element of the cell wall is cellulose. Cellulose is vital to plant fitness and the protein complex that creates it is an excellent target for small molecule inhibition to create herbicides. In the following thesis many small molecules (SMs) from a diverse library were screened in search of new cellulose biosynthesis inhibitors (CBI). Loss of cellular expansion was the primary phenotype used to search for putative CBIs. As such, this was approached in a forward …

Competency-Based Education: A Framework For A More Efficient And Safer Aviation Industry, Flavio A. C. Mendonca, Julius Keller, Brian G. Dillman

Publications

Aircraft design and reliability as well as pilots’ education and training have steadily and significantly improved in the last 20 years. Nevertheless, high-profile accidents still occur, even when the aircraft and related systems are operating adequately. Controlled flight into terrain, runway incursion accidents, and loss of control in flight are examples of mishaps in which inadequate decision-making, poor leadership, and ineffective communication are frequently cited as contributing factors. Conversely, the investigation of accidents (e.g., US Airways Flight 1549, in the U.S. on Jan. 15, 2009) and serious incidents (e.g., TAM Linhas Aereas Flight 3756 in Brazil on June 17, 2011) …

Fluid-Wall Interactions In Pseudopotential Lattice Boltzmann Models, Cheng Peng, Luis F. Ayala, Orlando M. Ayala

Engineering Technology Faculty Publications

Designing proper fluid-wall interaction forces to achieve proper wetting conditions is an important area of interest in pseudopotential lattice Boltzmann models. In this paper, we propose a modified fluid-wall interaction force that applies for pseudopotential models of both single-component fluids and partially miscible multicomponent fluids, such as hydrocarbon mixtures. A reliable correlation that predicts the resulting liquid contact angle on a flat solid surface is also proposed. This correlation works well over a wide variety of pseudopotential lattice Boltzmann models and thermodynamic conditions.

Ship Deck Segmentation In Engineering Document Using Generative Adversarial Networks, Mohammad Shahab Uddin, Raphael Pamie-George, Daron Wilkins, Andres Sousa Poza, Mustafa Canan, Samuel Kovacic, Jiang Li

Engineering Management & Systems Engineering Faculty Publications

Generative adversarial networks (GANs) have become very popular in recent years. GANs have proved to be successful in different computer vision tasks including image-translation, image super-resolution etc. In this paper, we have used GAN models for ship deck segmentation. We have used 2D scanned raster images of ship decks provided by US Navy Military Sealift Command (MSC) to extract necessary information including ship walls, objects etc. Our segmentation results will be helpful to get vector and 3D image of a ship that can be later used for maintenance of the ship. We applied the trained models to engineering documents provided …

Schizophrenia Classification Using Resting State Eeg Functional Connectivity: Source Level Outperforms Sensor Level, Sima Azizi, Daniel B. Hier, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

Disrupted Functional and Structural Connectivity Measures Have Been Used to Distinguish Schizophrenia Patients from Healthy Controls. Classification Methods based on Functional Connectivity Derived from EEG Signals Are Limited by the Volume Conduction Problem. Recorded Time Series at Scalp Electrodes Capture a Mixture of Common Sources Signals, Resulting in Spurious Connections. We Have Transformed Sensor Level Resting State EEG Times Series to Source Level EEG Signals Utilizing a Source Reconstruction Method. Functional Connectivity Networks Were Calculated by Computing Phase Lag Values between Brain Regions at Both the Sensor and Source Level. Brain Complex Network Analysis Was Used to Extract Features and …

Modeling Conductive Properties Of Highly Aligned Single-Walled Carbon Nanotube And Graphene Thin Films, Mark Joseph Foster

Browse all Theses and Dissertations

Properties of layered material systems have been investigated since the 1940s and are currently very well understood. Classical mechanics combined with the well-developed lamination theory enable the prediction of multi-layered system properties once the properties of its constituents are known. The ability of the lamination theory to predict the conductive properties of multi-layered highly aligned single-walled carbon nanotube (SWCNT) and graphene thin films is investigated. Experimental results showed that the classical lamination theory is not valid in the case of the investigated nanofilm system. Using experimental results, we developed a closed form model using MATLAB which enabled the correct prediction …

Hard Hat Ambient Liability Observer (Halo), Hunter Hykes, Nathan Kish, Brian Thomson

Williams Honors College, Honors Research Projects

Capturing workplace incident information is a growing area of concern for most companies. To assist with this, the design team proposed the H.A.L.O. This design uses time-of-flight sensors connected to LEDs to create a proximity-based hazard warning system. It also records incident data using an accelerometer and micro-SD card. This helps workers avoid some of the most common workplace injuries, slips, trips, and falls and accidental collisions.

Students have created a design with engineering, and marketing requirements that accomplish this task. The proposed design allows for this monitoring and mitigation systems to be attached to hard hats. Team members developed …

Electrospinning Of Formic Acid/Acetic Acid And Nylon-6 Solutions For Wearable Hydration Sensors, Nichole Cooper, Jonathan Doak

Williams Honors College, Honors Research Projects

Students have been working on the development of wearable hydration sensors at the startup company RooSense. The goal of the company is to develop a lightweight wearable sensor that enables the user to know their hydration level, thus elevating their performance goals. To measure the hydration of the wearer, the sodium and other salt ions are collected from the user’s sweat as they exercise. This sweat is analyzed as it is collected to give the user an exact level of hydration, so they know how much fluids they need. The production of this ion sensor requires numerous steps and iteration …

Ecg Monitoring In Athletes, Jalal Jwayyed, Kelly Purgason, Joseph Linder, Annamarie Alfery, Silvia Furman

Williams Honors College, Honors Research Projects

Athletes and medical personnel need reliable methods to monitor vital signs and detect potentially life-threatening issues before they occur. Electrocardiograph (ECG) monitors are currently the best method of detecting heart-related health issues. Current ECG monitors worn by athletes are difficult to use and lack the ability to track ECGs in real time. Through research and interviews with various clinicians, further problems have been identified that include poor electrode adhesion, and a lack of compatibility with the equipment worn by athletes. Our team proposes to develop solutions that will improve performance and comfort associated with ECG monitors for athletic applications. This …

Cold Plasma Enhanced Active Sites On Supported Nip Nanoparticles For The Oxygen Evolution Reaction, Michael Ricci

Williams Honors College, Honors Research Projects

Identifying materials to efficiently facilitate the oxygen evolution reaction (OER) is key to advancing water electrolysis, an essential technology in the pathway towards a sustainable energy future. Here, we explore cold-plasma treatment as a facile method to enhance the activity of NiP nanoparticles supported on activated carbon. NiP nanoparticles were synthesized on an activated carbon support using a solid-state method and were then treated with argon, oxygen, and hydrogen plasmas for extended times. In all cases, plasma treatment reduced the number of active sites on the support. OER activity was evaluated by testing the materials in alkaline conditions. The activities …

Analyzing And Improving Calculation And Tuning Process For A Uav, Laurel Wardell

Williams Honors College, Honors Research Projects

The nature of this project is confidential and cannot be disclosed in detail. Generally, this project deals with the analysis of a control system of a UAV with several electric motors and gimbals. The goal of this analysis is to improve control calculations for increased stability. In addition, development has been started on an application to streamline the tuning of gains for this particular controller, allowing for more efficient use of precious flight time.

Development Of A Heavy-Duty Aluminum Rail Hole Punch Manufacturing Fixture, Reese Hawthorne

Williams Honors College, Honors Research Projects

This report details the development and testing of an improved replacement for a worn manufacturing fixture which was used to position the location of four drilled holes on the outside of a heavy-duty aluminum rail. Commissioned by JohnDow Industries, the new process improves upon the old one by implementing an electro-hydraulic punch and new locating fixture. The new design produced higher quality slots, decreased cycle time by 15%, and aimed to improve the ergonomics of the process for the employees. All these factors contributed to making the aluminum rails a high-quality end product for JohnDow’s customers. Further iteration of the …

Customizable Armor Set, Olivia Reedy

Williams Honors College, Honors Research Projects

This project is intended to help people who make costume armor by reducing the amount of time and money it takes to create a set of armor. Making armor can take a lot of resources for beginners, and this project is intended to help hobbyists with that process. This customizable armor set goes through the engineering design process, from the initial design of the parts to creating the prototype using vacuum forming. The prototype armor can be painted and adhered to using acrylic paint and contact cement, respectively, and fits three sizes of small, medium, and large.

Ping Pong Ball Collecting Robot, Gina Lanese, Jason Colonna, Sarah Kuchcinski, Johndavid Rogers

Williams Honors College, Honors Research Projects

The ping pong ball collecting robot will collect ping pong balls in a ping pong arena, such as after a game or practice session. Ball collection is now typically done by a human, collecting the balls either by hand or with a net. A robot, autonomously collecting the ping pong balls from the floor, would allow for the time spent playing or practicing to be maximized. The team will design the software and hardware for the robot, including the mechanical system, the software, and circuit boards. This robot will serve as a capstone project for the senior design team consisting …

Atmospheric Corrosion Of Galvanically Coupled Aluminum Alloys And Carbon Steel, Mitchell Felde

Williams Honors College, Honors Research Projects

Aluminum alloys are a steadily growing material being commonly used in lieu of typical steels. Additional alloying, heat treatment, and other property enhancing processes are expanding the use of these alloys. However, with this expansion, galvanic corrosion is becoming more of an issue in the design stage due to the combination of these alloys with steels. The automotive industry is one industry where the use of aluminum alloys is becoming common practice. Aluminum alloys provide a lightweight aspect over the conventional carbon steel that was used previously. As a result of this transition towards more lightweight materials, galvanic coupling is …

Testing The Effectiveness Of Various Fabrics For Use In Protective Face Coverings, Isaac Daley

Williams Honors College, Honors Research Projects

Facemask requirements have been heavily implemented as a result of the COVID-19 pandemic. The purpose of this study was to test various fabrics that could be used in face coverings and determine which materials are best for reducing virus transmission rates. Of the seven fabrics tested, five were conventional home-use fabrics and the other two were surfaces modified with hydrophobic organosilanes. Wettability and droplet adherence tests were performed on each material. The materials that performed the best were decyltrichlorosilane (DTS) modified cotton, perfluorotrichlorosilane (FTS) modified cotton, and polyester. Contact angles for water droplets on these fabrics were 106°, 93°, and …

Design For Additive Manufacturing (3d Printing), Michael O'Donnell, Michael J. Levy

Williams Honors College, Honors Research Projects

The goal of this project is to study the performance of a 3D printed mechanical part subjected to topology optimization. A part that is somewhat complex in its load bearing and geometry will be selected. That part will then be designed, finite element analysis will be performed on it to optimize its topology, and then it will be 3D printed and tested. The goal of topology optimization is to either save material cost and/or part weight due to the ability of 3D printing to manufacture parts with complex and obscure geometry.

Camper Conversion, Owen Christian Hafler, Zebediah Paul Benedict Zehentbauer, Madilyn Beatrice Willis, Zachary Eli Owen, Justin Robert Nicholas

Williams Honors College, Honors Research Projects

The COVID-19 pandemic of 2020-2021 has seen hundreds of thousands sequestered in quarantine for long periods of time. When quarantined in an urban setting, many cannot leave their respective apartment buildings which only adds to the strain of isolation. In the context of isolation, the design team of Hafler, Nicholas, Owen, Willis, and Zehentbauer personally sought to incorporate their individual enthusiasm for nature with the benefits of living off-grid. After initial research and deliberation, the team discovered the “Skoolie” community and the plans for a mobile tiny home began production.

The team outlined the design project as the full design, …

Design And Testing Of A Feed-Forward Control System For Deployable Vortex Generators Dependent On Angle Of Attack, Solomon B. Whitmire, Christopher J. Chapanar, Kirklin M. Anderson, Nickalus R. Amon, Daniel W. Chech

Williams Honors College, Honors Research Projects

A vortex generator (VG hereafter) is a common feature of an aircraft wing that disturbs the flow on the leading edge of the wing, thus energizing the boundary layer and reducing flow separation. For an aircraft experiencing flow separation, VGs can increase the lift-to-drag ratio of the wing and prevent stall; however, if flow separation isn’t an issue, the unnecessary frontal area of the VGs has the potential to produce parasitic drag. This study seeks to determine whether the use of a deployment system can improve the performance of VG’s by raising or lowering them depending on the angle of …

Design And Implementation Of Fully Integrated Cmos On-Chip Bandpass Filter With Wideband High-Gain Low Noise Amplifier, Yu Wang

Browse all Theses and Dissertations

Current trends of fully integrated CMOS on-chip bandpass filter are classified into 1) the component level (i.e., active inductor, Q-enhanced passive inductor, negative resistance cancellation), and 2) the circuit level (i.e., adding transmission zeros on stopband, applying the zigzag technique for fewer inductors, superposition of different resonators). The demand for monolithic designs for portable devices attracts market interest in a fully integrated CMOS on-chip bandpass filter. Optimized minimal inductors (OMI) bandpass filter is a good platform for use in both active and passive bandpass filters, mainly because 1) it provides good stopband rejection for high interface attenuation, and 2) the …