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Articles 4261 - 4290 of 195925

Full-Text Articles in Engineering

Unveiling Microplastic Removal And Characteristics In Wastewater From Two Municipal Wastewater Treatment Facilities In Indonesia, Nurul Setiadewi, Prayatni Soewondo, Cynthia Henny Jan 2026

Unveiling Microplastic Removal And Characteristics In Wastewater From Two Municipal Wastewater Treatment Facilities In Indonesia, Nurul Setiadewi, Prayatni Soewondo, Cynthia Henny

Applied Environmental Research

Wastewater treatment plants (WWTPs) are considered an entrance pathways for microplastic (MP) pollution in aquatic environments. This study reveals the removal and characteristics of MPs in wastewater from two municipal WWTPs in Indonesia. The influent contained 17.1 ± 5.65 particles L-1 (WWTP A) and 15.45 ± 4.31 particles L-1 (WWTP B), whereas the effluent contained 1.41 ± 0.01 and 1.5 ± 0.16 particles L-1. The removal efficiency was 91.75% for WWTP A and 90.32% for WWTP B, with no statistically significant difference (p > 0.05). WWTP A employed advanced treatment units, whereas WWTP B used a conventional pond-based system. MPs were …


Activated Carbon Prepared From Residual Eucalyptus Wood For The Removal Of Methyl Orange: Equilibrium, Kinetics, Thermodynamics, And Desorption, Mathin Jaikua, Phuthidhorn Thanaphu, Sunisa Ungwiwatkul, Jakkrawut Maitip, Kanyarak Prasertboonyai Jan 2026

Activated Carbon Prepared From Residual Eucalyptus Wood For The Removal Of Methyl Orange: Equilibrium, Kinetics, Thermodynamics, And Desorption, Mathin Jaikua, Phuthidhorn Thanaphu, Sunisa Ungwiwatkul, Jakkrawut Maitip, Kanyarak Prasertboonyai

Applied Environmental Research

This research utilizes activated carbon derived from residual Eucalyptus wood (EW) for the removal of methyl orange (MO). The residual Eucalyptus wood-based activated carbon (EWAC) was produced through carbonization at 400 °C (EWC) followed by activation with a mass ratio of H3PO4 to EWC of 1:3, which was conducted at 800 °C for 1 h. The characterization of the EWAC involved various analytical techniques, including FTIR, XRD, BET, and CHN analysis. The adsorption parameters, such as pH (range: 3–8), adsorbent dose (range: 0.01–0.5 g per 50 mL of MO solution), contact time (range: 5–720 min), initial MO concentration (range: 5–600 …


Reduction Of Cr(Vi) With Infrared Light And Chemical Adsorption Of Cr(Iii) By A God-Crown/Bentonite Composite For Electroplating Waste Remediation, Andre Taufik Kurniawan, Muhammad Djoni Bustan, Sri Haryati Jan 2026

Reduction Of Cr(Vi) With Infrared Light And Chemical Adsorption Of Cr(Iii) By A God-Crown/Bentonite Composite For Electroplating Waste Remediation, Andre Taufik Kurniawan, Muhammad Djoni Bustan, Sri Haryati

Applied Environmental Research

Heavy metal pollution, particularly chromium (Cr) from electroplating industrial waste, has severely threatened environmental quality and human health. This study aims to develop a composite adsorbent material based on bentonite and god crown biomass capable of removing chromium ions from liquid waste through a combination of reduction and adsorption mechanisms. The god crown/bentonite (GC/Bt) composite was synthesized at a mass ratio of 2:1 and calcined at 900°C. FTIR characterization revealed active functional groups (–OH, C=O, Si–O, and Al–O–Si), whereas BET analysis revealed a mesoporous structure (surface area 31.12 m2 g-1, pore diameter 4.37 nm) suitable for ion diffusion. The reduction …


Assessment Of The Influence Of Human Activities On The Occurrence Of Forest Fires In Thailand Via Multiple Linear Regression (Mlr), Sittipong Ruktamatakul, Jirarat Insuk, Benjaporn Pinwongpet, Sarisa Ruktametakul, Pornpis Yimprayoon Jan 2026

Assessment Of The Influence Of Human Activities On The Occurrence Of Forest Fires In Thailand Via Multiple Linear Regression (Mlr), Sittipong Ruktamatakul, Jirarat Insuk, Benjaporn Pinwongpet, Sarisa Ruktametakul, Pornpis Yimprayoon

Applied Environmental Research

Forest fires represent one of the most critical environmental challenges in Thailand, with impacts varying depending on forest type, fuel characteristics, terrain conditions, fire intensity, and the frequency of fire occurrence on the same landscape. While forest fires can contribute to ecosystem degradation, biodiversity loss, and the depletion of natural resources, such effects are not uniformly severe across all forest ecosystems. Understanding the human-induced factors contributing to forest fire occurrence is crucial for developing effective prevention strategies and promoting sustainable forest management. This study aimed to identify the anthropogenic factors influencing forest fire areas in Thailand via multiple linear regression …


Effect Of Chromium Doping On The Uv- And Sunlight-Driven Photocatalytic Performance Of Srtio3, Ro’Ikhatul Jannah, Dianisa Khoirum Sandi, Fahru Nurosyid, Risa Suryana, Didier Fasquelle, Yofentina Iriani Jan 2026

Effect Of Chromium Doping On The Uv- And Sunlight-Driven Photocatalytic Performance Of Srtio3, Ro’Ikhatul Jannah, Dianisa Khoirum Sandi, Fahru Nurosyid, Risa Suryana, Didier Fasquelle, Yofentina Iriani

Applied Environmental Research

Chromium (Cr)-doped strontium titanate (SrTiO3, STO) photocatalysts with compositions of SrTi1-xCrxO3 (x = 0, 5, and 10%) were prepared via the coprecipitation method. This study aimed to investigate the effects of Cr doping on structural, morphological, and optical properties. Furthermore, this work aimed to examine the photocatalytic performance of pure and Cr-doped STO against methylene blue (MB) degradation under ultraviolet (UV) and sunlight exposure. X-ray diffraction confirmed the formation of the cubic STO phase and the insertion of the Cr dopant in the STO structures. Furthermore, Cr doping reduced the lattice constant, crystallite size, and average particle size and narrowed …


Fabrication Of Acid-Modified Corn Plant By-Product-Based Biochar For Efficient Adsorption Of Sulfamethoxazole From Aqueous Solutions, Thi An Hang Nguyen, Thi Duyen Le, Thi Hang Bui Jan 2026

Fabrication Of Acid-Modified Corn Plant By-Product-Based Biochar For Efficient Adsorption Of Sulfamethoxazole From Aqueous Solutions, Thi An Hang Nguyen, Thi Duyen Le, Thi Hang Bui

Applied Environmental Research

Antibiotic pollution is of great interest owing to growing concerns about antibiotic resistance worldwide. This study aims to fabricate acid-modified biochar (CBM-A) from corn plant byproducts (CRs) for sulfamethoxazole (SMX) adsorption in aqueous solutions. CBM-A was synthesized via pyrolysis at 700 °C and modified with 14% H3PO4. Kinetics, isotherms, and thermodynamics were investigated in combination with material characterization to elucidate the adsorption behaviors and mechanisms. The results showed that pyrolysis and acid modification effectively enhanced SMX adsorption by CR because of the increased number of binding groups, specific surface area, and porosity. SMX adsorption on CBM-A was optimized at a …


Blue Carbon Stock Assessment And Climate Resilience Potential Of Mangrove Forest In Hung Thang Commune, Vietnam, Hla Phong Ko, Pham Hong Tinh, Nguyen Thuy Duong Jan 2026

Blue Carbon Stock Assessment And Climate Resilience Potential Of Mangrove Forest In Hung Thang Commune, Vietnam, Hla Phong Ko, Pham Hong Tinh, Nguyen Thuy Duong

Applied Environmental Research

Mangrove forests are vital blue carbon sinks that contribute to climate change mitigation and coastal resilience. This study assessed the carbon stock and spatial‒temporal dynamics of a mangrove forest in Hung Thang commune, Hai Phong Province, Vietnam, via a combination of field measurements, soil organic carbon (SOC) analysis, and normalized difference vegetation index (NDVI)-based remote sensing models. The results revealed that mangroves in the Hung Thang community store an average of 87.42 tC ha-1, with SOC accounting for approximately 19% of the total carbon. A generalized additive model (GAM) analysis revealed a consistent increase in carbon stocks between 1996 and …


Anaerobic Digestion Of Variable, Heterogeneous Organic Wastes Under Changing Operational Conditions And Bioaugmentation: Impacts On Process Performance And Microbiome Dynamics, Victoria Holliday Jan 2026

Anaerobic Digestion Of Variable, Heterogeneous Organic Wastes Under Changing Operational Conditions And Bioaugmentation: Impacts On Process Performance And Microbiome Dynamics, Victoria Holliday

Theses and Dissertations--Biosystems and Agricultural Engineering

Expanding the adoption of anaerobic digestion (AD) is limited by system instabilities caused by feedstock composition and variability. Understanding how changes in feedstock and operational parameters influence microbiome dynamics is essential for developing biology-driven strategies to improve digester stability.

Two semi-continuous reactors, an experimental and a control, operated over 39 weeks across five phases with varying feedstocks and organic loading rates. Substrate-specific enrichment cultures were developed for bioaugmentation and implemented in select phases to assess its impact. Both reactors exhibited similar performance, transitioning through periods of stability, stress, and recovery in response to operational changes. Corresponding shifts in dominant taxa …


Proposed Design Approach Of Bolted Cruciform Stiffened End-Plate Connections And Bolted Circular Flange Plate Connections Under Combined Loading For Enhanced Economy And Performance, Cesar E. Aguirre Jan 2026

Proposed Design Approach Of Bolted Cruciform Stiffened End-Plate Connections And Bolted Circular Flange Plate Connections Under Combined Loading For Enhanced Economy And Performance, Cesar E. Aguirre

Civil Engineering Dissertations

This research will deliver a substantive contribution to the advancement of design practice for bolted circular flange connections and cruciform stiffened end-plate connections — critically evaluating existing approaches, identifying their limitations, and proposing evidence-based design frameworks that enhance structural performance, predictability, and safety across relevant engineering applications.In addition provide economical benefits.


The Lie Group Basis Of Neuronal Membrane Architecture: Why The Hodgkin–Huxley Equations Take Their Form, Robert Melendy, Daniel Blue Jan 2026

The Lie Group Basis Of Neuronal Membrane Architecture: Why The Hodgkin–Huxley Equations Take Their Form, Robert Melendy, Daniel Blue

Faculty Publications - Department of Electrical Engineering and Computer Science

The Hodgkin–Huxley equations have successfully described neuronal excitability for over seventy years, yet their mathematical structure remains empirically justified rather than theoretically explained. Why are gating variables bounded between 0 and 1? Why does sodium conductance depend on m3h rather than other combinations? Why does potassium depend on n4? Why do all rate functions contain exponential voltage dependencies? Why are the kinetics first-order? We demonstrate that these structural features arise naturally from three fundamental physical symmetries governing ion channel dynamics: the compactness of conformational state space, the scaling invariance of membrane conductance, and temporal translation invariance. …


Synthesis Of Nickel Nanoparticles By Gamma Irradiation And Femtosecond Laser Ablation, V. M. Rao, Y. Han, H. Tsai, C. H.C. Giraldo, T. Akyurek Jan 2026

Synthesis Of Nickel Nanoparticles By Gamma Irradiation And Femtosecond Laser Ablation, V. M. Rao, Y. Han, H. Tsai, C. H.C. Giraldo, T. Akyurek

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

Nickel nanoparticles were synthesized by (i) gamma irradiation of aqueous nickel chloride precursors and (ii) double scan femtosecond laser (FSL) ablation of a pure nickel foil in water. The nanoparticles produced by FSL ablation were further stabilized in acetone. Gamma radiolysis yielded nickel nanoparticles in the 2–22 nm range, with the average particle diameter governed by the total absorbed dose. Nickel nanoparticles produced by double scan FSL ablation were in the 2–17 nm range but less monodispersed than the nanoparticles produced via gamma radiolysis. FSL ablation proved to be superior in terms of yielding a higher number of smaller nanoparticles …


Formalizing Asymmetric Control-Telemetry Separation In Distributed Industrial Control Systems, Andrew Manison Jan 2026

Formalizing Asymmetric Control-Telemetry Separation In Distributed Industrial Control Systems, Andrew Manison

College of Graduate Studies: Theses & Dissertations

Distributed industrial control systems often place control and telemetry traffic on the same communication substrate even though the two workloads impose different requirements. Control paths need bounded request-response latency and predictable acknowledgement semantics, whereas telemetry paths benefit from scalable publish-subscribe fanout and tolerance for consumer-side delay. This thesis argues that, for the tested class of mixed workloads on shared commodity infrastructure, these communication roles should be separated architecturally rather than forced through a single protocol. To evaluate that claim, the thesis formalizes an asymmetric control- telemetry pattern and instantiates it in the Asymtra framework using gRPC for synchronous control and …


Effect Of Wall Movement On Porosity Formation In Ductile Iron Castings Under Varying Processing Parameters, Shamsul Alam Jan 2026

Effect Of Wall Movement On Porosity Formation In Ductile Iron Castings Under Varying Processing Parameters, Shamsul Alam

College of Graduate Studies: Theses & Dissertations

Shrinkage porosity is a major defect that significantly impairs the mechanical properties and overall performance of ductile iron castings. Although graphite formation during solidification induces volumetric expansion, this expansion alone is insufficient to fully compensate for the shrinkage occurring throughout solidification. During the solidification and cooling of ductile iron, multiple phase transformations occur, resulting in dynamic volume changes that exert pressure on mold walls and internal cavities. These pressures can deform mold walls and casting surfaces, leading to defects such as swell and porosity, while also influencing shrinkage formation. This study aims to analyze the mechanisms of porosity formation and …


Viscoelastic Behavior Of Magnetically Filled Pdms Elastomers: Influence Of Filler Loading And Particle Type, Madison Procyk Jan 2026

Viscoelastic Behavior Of Magnetically Filled Pdms Elastomers: Influence Of Filler Loading And Particle Type, Madison Procyk

College of Graduate Studies: Theses & Dissertations

Magnetorheological elastomers (MREs) offer a promising pathway for soft, magnetically actuated drug‑delivery systems, yet material‑selection guidelines remain unclear due to limited comparative data across particle chemistries, size scales, and concentrations. This study systematically evaluates how magnetic filler type (carbonyl iron and magnetite) and particle size (micro vs. nano), at two weight percentages – 40 wt% and 50 wt% – in Sylgard 184 PDMS influence the viscoelastic behavior of MREs intended for compliant biomedical actuation. Eight particle formulations were prepared through sieving, controlled mixing, vacuum degassing, and isotropic curing, producing nineteen total specimens (16 with filler particles and 3 without). Dynamic …


Influence Of The Sst K-Ω Stress-Limiter Coefficient On Transonic Shock Buffet Prediction For The Oat15a Supercritical Airfoil, Melinawo Vowotor Jan 2026

Influence Of The Sst K-Ω Stress-Limiter Coefficient On Transonic Shock Buffet Prediction For The Oat15a Supercritical Airfoil, Melinawo Vowotor

College of Graduate Studies: Theses & Dissertations

Transonic shock buffet predictions using the Shear Stress Transport (SST) k–ω turbulence model are known to be sensitive to the stress-limiter coefficient a₁, yet no systematic investigation of this sensitivity exists. This thesis presents a parametric study of a₁ for two-dimensional URANS simulation of shock buffet on the OAT15A supercritical airfoil at M = 0.73 and Re = 3 × 10⁶. Eleven a₁ values (0.25–0.37) are examined at α = 3.5°, and a matrix of five a₁ values across five angles of attack (3.0°–3.9°) maps the interaction with incidence. The results reveal that a₁ acts as a bifurcation parameter: a …


Effects Of Composition, Nodularity, Pouring Temperature, Inoculation, And Mold Strength On Wall-Movement In Sgi Castings During Solidification And Cooling, Noah Brack Jan 2026

Effects Of Composition, Nodularity, Pouring Temperature, Inoculation, And Mold Strength On Wall-Movement In Sgi Castings During Solidification And Cooling, Noah Brack

College of Graduate Studies: Theses & Dissertations

The iron-carbon casting alloy known as spheroidal graphite iron (SGI), nodular graphite iron, or ductile iron (DI) experiences complex volume changes during its solidification and cooling as graphite nodules and austenite form. These volume changes result in forces on the mold cavity walls and can deform the mold walls in cases when mold walls lack the strength to resist the deformation. This wall movement can cause the formation of casting defects such as swell, warped part geometry, and shrinkage porosity. Though this phenomenon has been studied in the past, it remains difficult to predict casting wall movement with existing data. …


Rm Sotheby’S Construction Of Value In The High-End Car Market, Pablo Mijares Musi Jan 2026

Rm Sotheby’S Construction Of Value In The High-End Car Market, Pablo Mijares Musi

MA Theses

The purpose of my thesis is to tell and enlighten any readers how the most prestigious and iconic auction house in the world, RM Sotheby’s sells more than just cars from the high-end car market and how the auction house adds value to through storytelling and provenance from each vehicle.  In today’s luxury market economics, we see somewhat of a radical shift. The high-end car market has moved into a very refined area where these beautiful machines are no longer seen and appraised just for their aesthetic design and mechanical engineering, now we see new value drivers for these works …


Drone Endurance In Hydrogen Fuel Cell Hybrid Technologies: Power Architectures And Design Strategies, Yaw Chong Tak, Tarek Abedin, Johnny Koh Siaw Paw, Jagadeesh Pasupuleti, Tan Jian Ding, Tiong Sieh Kiong, K. Kadirgama, F. Benedict, Mohammad Nur-E-Alam Jan 2026

Drone Endurance In Hydrogen Fuel Cell Hybrid Technologies: Power Architectures And Design Strategies, Yaw Chong Tak, Tarek Abedin, Johnny Koh Siaw Paw, Jagadeesh Pasupuleti, Tan Jian Ding, Tiong Sieh Kiong, K. Kadirgama, F. Benedict, Mohammad Nur-E-Alam

Research outputs 2022 to 2026

This study delivers an exhaustive exploration of novel and hybrid power systems for Unmanned Aerial Vehicles (UAVs) aimed at improving endurance, efficiency, and mission performance. In the wake of increasing requirements for long-endurance and high-performance UAVs, traditional battery systems are limited by their energy density and lifetime. To overcome this, the research compares four primary power sources: hydrogen fuel cells, lithium-based batteries, photovoltaic cells, and supercapacitors, with a focus on their hybrid architecture integration. The originality of this research is in the relative comparison of these power sources in multi-mode UAV operations, with an emphasis on their performance, energy management …


Ai-Enhanced Smart Sensors For Heavy Metal Detection In Water Treatment, Fatemeh Noorisafa, Amir Razmjou, Asghar Taheri-Kafrani, Fatemeh Ejeian, Mohsen Asadnia, Hamidreza Akbari Ghavamabadi Jan 2026

Ai-Enhanced Smart Sensors For Heavy Metal Detection In Water Treatment, Fatemeh Noorisafa, Amir Razmjou, Asghar Taheri-Kafrani, Fatemeh Ejeian, Mohsen Asadnia, Hamidreza Akbari Ghavamabadi

Research outputs 2022 to 2026

Artificial intelligence (AI) enhances biosensor design by efficiently processing and modeling environmental data. This study employs machine learning algorithms to optimize biosensor parameters for the detection of trace-level heavy metals in aquatic environments, utilizing enzymes, DNAzymes, and aptamers as recognition elements. Machine learning models, including decision trees, random forests, gradient boosting, ensemble neural networks, and GLMM,were trained on extensive laboratory datasets. Among these, the random forest model exhibited the highest predictive accuracy, achieving 71 % for the limit of detection (LOD), 75 % for the minimum concentration of linearity, and 62 % for the maximum concentration of linearity. The AI-driven …


Wings Of Perception: Investigating Customer Sentiments In Indian Aviation Sector, Yashodhan Karulkar, Kaiwan Vaghchhipawala, Aditya Trivedi, Anushree Talekar Jan 2026

Wings Of Perception: Investigating Customer Sentiments In Indian Aviation Sector, Yashodhan Karulkar, Kaiwan Vaghchhipawala, Aditya Trivedi, Anushree Talekar

Journal of International Technology and Information Management

India's aviation sector, a key contributor to the nation's economy, has experienced rapid growth, supporting nearly 7.5 million jobs and contributing approximately $30 billion annually to the GDP (Gross Domestic Product). The growth, driven by increased demand for air travel and government incentives, has resulted in more competition among carriers. In the competitive market, it is necessary to understand customer preferences to enhance the quality of service and maintain a competitive edge. The dissemination of customer opinions on social media and review platforms offers airlines the opportunity to access passenger views. However, extracting useful information from this unstructured data is …


Business Process Redesign For Reducing Undelivered Product Return Losses In E-Commerce – An Explainable Ai Approach, Venkataraghavan Krishnaswamy, Deepa R, Himanshu Sharma Jan 2026

Business Process Redesign For Reducing Undelivered Product Return Losses In E-Commerce – An Explainable Ai Approach, Venkataraghavan Krishnaswamy, Deepa R, Himanshu Sharma

Journal of International Technology and Information Management

Product returns in e-commerce affect the profitability of the e-tailer. We adopt a two-stage approach to reduce undelivered product returns in an e-commerce firm. First, we develop and compare machine learning techniques—logistic regression, decision trees, Naïve Bayes, random forest, adaptive boosting, gradient boosting, stochastic gradient boosting, and deep neural networks—on their ability to predict undelivered returns. Next, we use explainable methods, such as relative importance and Shapley values, to develop insights from the best-performing machine learning model. Finally, we use these insights and the predictive model to redesign the firm’s order fulfillment and return processes. A Post-implementation evaluation of the …


Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton Jan 2026

Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton

Department of Biomedical and Translational Sciences Faculty Publications

We report the first crystal structure of the telmisartan-tempol conjugate 2,2,6,6-tetramethyl-1-(λ'-oxidaneyl)piperidin-4-yl 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl]-[1,1'-biphenyl]-2-carboxylate free radical (YK-4-250, C₄₂H₄₆N₅O₃), a dual-function inhibitor designed to target both the angiotensin II type 1 receptor (AT₁R) and reactive oxygen species (ROS). Structural analysis reveals a unique crystal architecture in which the nitroxide radical is stabilized within a sterically protected environment while preserving the telmisartan pharmacophore essential for high-affinity receptor antagonism. YK-4-250 is a novel small-molecule conjugate of telmisartan and tempol that incorporates a catalytic stabilized nitroxide radical and was rationally designed to mitigate gastrointestinal acute radiation syndrome (GI-ARS).


Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson Jan 2026

Dietary Intake Of Micro- And Nanoplastics: Potential Adverse Gi Effects On Microbiome, Inflammation, And Neoplasia, Michael Saadeh, Gordon Hong, Sana Rabeeah, Priyata Dutta, Edward C. Oldfield, Iv, David A. Johnson

Department of Medicine Faculty Publications

Micro- and nanoplastics (MNPs) are pervasive in food-contact environments and the human diet, positioning the gastrointestinal (GI) tract as the primary portal of entry and a plausible site of early biological effects. Human exposure is supported by detection of microplastics in stool and colon tissue, and emerging clinical studies report associations between fecal microplastic burden and GI disease states, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). Preclinical studies provide mechanistic plausibility, reporting that ingested MNPs can modulate microbial ecology, alter mucus membrane integrity, increase intestinal permeability through changes in cellular tight junction biology, and induce inflammatory gene expression. …


Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey Jan 2026

Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey

Bioelectrics Publications

Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …


Determining The Electric Field In A 10 Ns Pulsed Plasma In Fuel-Air Mixtures Using Efish, Md Ziaur Rahman, Christopher J. Kliewer, Brian D. Patterson, Chunqi Jiang Jan 2026

Determining The Electric Field In A 10 Ns Pulsed Plasma In Fuel-Air Mixtures Using Efish, Md Ziaur Rahman, Christopher J. Kliewer, Brian D. Patterson, Chunqi Jiang

Bioelectrics Publications

Transient plasma ignition (TPI) utilizes non-equilibrium plasmas, produced by nanosecond high-voltage pulses, to improve lean-fuel combustion performance and reduce emission. It is known that the relatively high reduced electric field (E/N) in TPI plays an important role in generating energetic electrons and facilitating energy-efficient radical productions, resulting in reliable ignition for lean combustion. Determining the reduced electric field in the discharge is hence important for the understanding of the TPI process and ultimately allowing for the control of the plasma chemistry. This study reports spatiotemporally resolved measurements of the electric field (E) in a 10 ns pulsed plasma that is …


Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova Jan 2026

Establishment And Histopathological Characterization Of A Kyse-30 Subcutaneous Xenograft Model Of Esophageal Squamous Cell Carcinoma, Pavel A. Solopov, Alayna Enos, Mantas Silkunas, Giedre Silkuniene, Eleni Zivla, Andrei G. Pakhomov, Olga N. Pakhomova

Bioelectrics Publications

Background/Objectives: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor prognosis and limited treatment options, highlighting the need for reliable preclinical models for translational research. Although xenograft models are widely used in cancer biology, systematic characterization of subcutaneous ESCC models under defined implantation conditions remains limited. The objective of this study was to systematically compare implantation conditions and define histopathological and growth-related parameters that enable reproducible tumor establishment while maintaining a practical experimental window for therapeutic studies. Methods: We established and characterized a subcutaneous ESCC xenograft model using human ESCC cell line KYSE-30 implanted into immunodeficient J:NU mice. …


Ammonia Synthesis By Nanosecond Pulsed Atmospheric Pressure Plasma Jets Impinging On Water, Zach Caudell, Lynnet Rich, Olga Pakhomova, Chunqi Jiang Jan 2026

Ammonia Synthesis By Nanosecond Pulsed Atmospheric Pressure Plasma Jets Impinging On Water, Zach Caudell, Lynnet Rich, Olga Pakhomova, Chunqi Jiang

Bioelectrics Publications

Developing energy-efficient technologies for carbon-neutral ammonia (NH₃) synthesis is critical for decentralized fertilizer production and global decarbonization. This study investigates generating NH₃ from water using a nanosecond pulsed atmospheric pressure plasma jet (ns‑APPJ) operating in either N₂ or dry air. The plasma jet reactor employed approximately 250 ns, up-to-22 kV pulses at 500 Hz to sustain a nonequilibrium discharge impinging directly on static liquid water. The kinetics, energy efficiency, and product selectivity of NH3 formation were quantified as functions of the pulse voltage, repetition frequency (PRF), and gas flow rate. NH₃ production increased linearly with treatment time and scaled strongly …


Combination Therapy With Hsp90 Inhibitors And Nanopulse Stimulation Synergistically Impedes Hepatocellular Carcinoma And Breast Cancer Growth In Mice, Christiana Dimitropoulou, Gagan Thangjam, Brittany P. Lassiter, Teresa Hooker, Ruben M. L. Colunga Biancatelli, John D. Catravas, Stephen J. Beebe Jan 2026

Combination Therapy With Hsp90 Inhibitors And Nanopulse Stimulation Synergistically Impedes Hepatocellular Carcinoma And Breast Cancer Growth In Mice, Christiana Dimitropoulou, Gagan Thangjam, Brittany P. Lassiter, Teresa Hooker, Ruben M. L. Colunga Biancatelli, John D. Catravas, Stephen J. Beebe

Bioelectrics Publications

Nanopulse Stimulation (NPS) represents a promising and innovative therapeutic approach to cancer. Heat shock protein 90 Inhibitors (HI), on the other hand, are currently under investigation in multi-drug chemotherapy trials for various types of malignancies. Here we present results of a combination therapy employing two HSP90 inhibitors (AUY-922 or 17-AAG) and NPS to ablate cancer growth. We firstly tested the inhibitors alone or in combination with NPS in vitro in N1S1 cells, and then into two models of orthotopic Hepatocellular Carcinoma (HCC) and 4T1-Luc breast cancer. NPS + HI reduced tumor growth more than the sum of HI and NPS …


Nanosecond Electric Pulses As A Novel In Situ Vaccination Strategy For Cancer Treatment: Mechanisms, Challenges And Prospects, Siqi Guo Jan 2026

Nanosecond Electric Pulses As A Novel In Situ Vaccination Strategy For Cancer Treatment: Mechanisms, Challenges And Prospects, Siqi Guo

Bioelectrics Publications

Nanosecond electric pulses (nsEPs) are an emerging pulsed-power technology with unique bioelectric characteristics distinct from conventional long-pulse electroporation. As a tunable physical modality, nsEPs can modulate intracellular structures, membrane dynamics, and signaling pathways. Increasing evidence supports nsEPs as a promising non-thermal tumor ablation approach due to their high spatial precision, preservation of critical tissue structures, and minimal adverse effects. One of the most significant discoveries associated with nsEP tumor ablation is the induction of potent systemic antitumor immunity, particularly in situ vaccination (ISV) effects and, in some cases, abscopal effects against distant untreated tumors. Substantial evidence demonstrates that nsEPs can …


Effect Of Elemental Additions On The Microstructure, Macrostructure, And Mechanical Properties Of Gray Iron, August E. Rautmann Jan 2026

Effect Of Elemental Additions On The Microstructure, Macrostructure, And Mechanical Properties Of Gray Iron, August E. Rautmann

College of Graduate Studies: Theses & Dissertations

Gray iron is composed primarily of an iron matrix and flake graphite, with the higher percentage of volume taken up by the iron matrix. The iron matrix is the transformation product of austenite, and this prior austenite structure is understood to affect the final grain structure. Grain structure affects the properties of a metal, with a finer structure recognized as beneficial for most properties. Thus, the refinement of austenite structure has potential in improving the material properties of gray iron. This study aims to advance the limited knowledge about the control of austenite grain size via elemental additions. Building off …