Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 36751 - 36780 of 195925

Full-Text Articles in Engineering

Developing An Energy Service Interface Specification, Jaime T. Kolln May 2022

Developing An Energy Service Interface Specification, Jaime T. Kolln

Dissertations and Theses

Developing an Energy Service Interface (ESI) specification requires engaging a community of stakeholders including grid operators, Information and Communication Technology implementors, integrators, and finally standards bodies who will define an interface that respects and boundaries of ownership and roles of responsibility in order to activate millions of Distributed Energy Resources for the provision of grid services. By applying Interoperability Maturity Model Criteria and ESI principles to common grid-DER service use cases, the Grid Modernization Lab Consortium team will engage subject matter experts to develop a specification, with an eventual goal of informing development of ESI compliant profiles or standards. The …


Impact Of The Ban On Illegal Mining Activities On Raw Water Quality: A Case-Study Of Konongo Water Treatment Plant, Ashanti Region Of Ghana, Sadique Anyame Bawa, Prince Antwi-Agyei, Martin Kyereh Domfeh May 2022

Impact Of The Ban On Illegal Mining Activities On Raw Water Quality: A Case-Study Of Konongo Water Treatment Plant, Ashanti Region Of Ghana, Sadique Anyame Bawa, Prince Antwi-Agyei, Martin Kyereh Domfeh

Journal of Sustainable Mining

The Government of Ghana prohibited Artisanal and Small-Scale Mining (ASM) operations from 2017 to 2018 as part of its strategy to address the socio-environmental issues caused by illegal mining activities, also referred to as “galamsey” operations. This study assessed the trend in the water quality of raw water abstracted at the Konongo Water Treatment Plant (WTP) for treatment before and after implementing the ban on “galamsey” operations. The main source of raw water for the Konongo WTP is the Anuru River. Secondary data on physicochemical water quality from 2006 to 2019 was sourced from the Konongo WTP and the Ashanti …


Improved Methodology For Monitoring The Impact Of Mining Activities On Socio-Economic Conditions Of Local Communities, Binay Prakash Pandey, Devi Prasad Mishra May 2022

Improved Methodology For Monitoring The Impact Of Mining Activities On Socio-Economic Conditions Of Local Communities, Binay Prakash Pandey, Devi Prasad Mishra

Journal of Sustainable Mining

Mining activities can cause tangible socio-economic improvements in the surrounding regions. Such potential has not been fully realized, owing to the fact that the socio-economic impact assessment processes exercised in India merely predict the footprint of industrial activity on the surrounding population. Consequently, project proponents are mandated to implement a management plan in cases of foreseeable negative consequences. However, both, the assessment study, as well as the process of implementation of a management plan, are riddled with significant gaps and limitations. Primary data collected for this research makes it apparent that, in comparison to the revenue generated from the mining …


Final Report - Climbing Robots With Automated Deployments Of Sensors And Nde Devices For Steel Bridge Inspection, Hung La, Son Nguyen May 2022

Final Report - Climbing Robots With Automated Deployments Of Sensors And Nde Devices For Steel Bridge Inspection, Hung La, Son Nguyen

Project AS-2

Automated solutions for infrastructure inspection are desirable. However, arduous engineering is delaying our progress. A complete system needs to deal with three main problems: (1) locomotive performance for high complexity of steel bridges including differential curvatures, transitions between beams and obstacles; (2) data collection capability, inclusive of visible and invisible damages, in-depth information such as vibration, coat, and material thickness, etc.; and (3) working condition made up of gust wind. To have such a complete system, this technical report presents novel developments in inspection-climbing robots. Four different robot versions are designed to look for the simplest and most effective configuration …


Black Beyond Measure: An Antideficit Exploration Of Cultural Capital Within A National Society Of Black Engineers (Nsbe) Chapter At A Predominantly White Institution (Pwi), Rhonda Harley May 2022

Black Beyond Measure: An Antideficit Exploration Of Cultural Capital Within A National Society Of Black Engineers (Nsbe) Chapter At A Predominantly White Institution (Pwi), Rhonda Harley

Dissertations

Historically, Black students have been excluded from Predominately White institutions (PWI) longer than welcomed to attend and matriculate (Harper et al., 2009). Due to this lack of inclusion, African American students' educational experiences often center on academic disparities, inequality of opportunity, and under-preparedness in career planning within the American education system. While there has been a fair amount of research on the lack of representation of Black students in the engineering disciplines, the heavy focus on quantitative data offers little insight into the unique ways students succeed and overcome institutional and systemic barriers in pursuit of their degree. Undergraduate experiences, …


Evaluating And Incorporating Site Variability In Different Geotechnical Engineering Applications, Md Habibur Rahman May 2022

Evaluating And Incorporating Site Variability In Different Geotechnical Engineering Applications, Md Habibur Rahman

LSU Doctoral Dissertations

Site investigation and characterization of subsurface soil conditions are crucial for geotechnical engineering design and analysis. Geotechnical properties vary inherently from one point to another within the same site. This study focused on evaluating the site variability from cone penetration tests (CPT) and soil boring data, and its implementation into the Load and Resistance Factor Design (LRFD) formulation. The total Coefficient of Variation (COVR,total) for each site was estimated from COVR,spatial (Spatial Coefficient of Variation) and COVR,method (Method Coefficient of Variation) which were then used to calibrate the resistance factors (ϕspatial, ϕtotal) …


Personal Library Organization And Tracking Application (Plot), Katie Honsinger May 2022

Personal Library Organization And Tracking Application (Plot), Katie Honsinger

Honors Projects

This project is inspired by my family's gloriously unmanageable book collection. Its primary goal is to provide a simple way to track your book collection, to avoid double-buying and help disorganized book-lovers everywhere stay sane! You can also track where a particular book is physically (or at least, where it should be!). There are a few features I'd still like to implement, but mainly I want this app to stay simple so it is easy to use and maintain.


Our Streets: Increasing Equity In Active Transportation Planning Through Community Outreach, Jordan Hoy May 2022

Our Streets: Increasing Equity In Active Transportation Planning Through Community Outreach, Jordan Hoy

Master's Projects and Capstones

ABSTRACT Significant research has demonstrated that active transportation infrastructure is essential for the growth and livability of San Francisco: it increases access to economic opportunities, promotes overall improved public health, encourages mobility without contributing to roadway congestion, prevents traffic injuries and fatalities, and supports the sustainability goals of the city. Despite the fact that communities of color will benefit the most from active transportation infrastructure development, historical disenfranchisement in tandem with a lack of diverse representation within public participation contributes to an inequitable distribution of walking and biking investments throughout the city of San Francisco. While research shows that Black …


A Proper Borehole Pattern Design For Coal Seam Methane Drainage In Tabas Coal Mine Using Comsol Multiphysics, Ali Bagherzadeh, Mehdi Najafi, Mohammad Fatehi Marji, Mehdi Noroozi May 2022

A Proper Borehole Pattern Design For Coal Seam Methane Drainage In Tabas Coal Mine Using Comsol Multiphysics, Ali Bagherzadeh, Mehdi Najafi, Mohammad Fatehi Marji, Mehdi Noroozi

Journal of Sustainable Mining

Optimizing the operational parameters of the borehole pattern in the coal seam includes the maximum amount of gas to be drained with the least amount of drilling, investment, and drainage time. The main purpose of this research is to properly design the drainage borehole pattern in the C1 coal seam of the Tabas coal mine. In this research, the Comsol Multiphysics software was used for numerical modeling of the boreholes. According to the method of diffusion of methane gas in a coal seam, the reduction of methane gas concentration and the amount of gas released from the coal blocks were …


In Situ Observations Of Fish Attraction To Light-Emitting Diodes On An Undersea Observation Deck, Makoto Tomiyasu, Yoko Tanouchi, Yasuzumi Fujimori, Minato Kaji, Takuma Hayashi, Naoto Matsubara, Hiroki Yasuma, Susumu Shimizu, Seiji Katakura May 2022

In Situ Observations Of Fish Attraction To Light-Emitting Diodes On An Undersea Observation Deck, Makoto Tomiyasu, Yoko Tanouchi, Yasuzumi Fujimori, Minato Kaji, Takuma Hayashi, Naoto Matsubara, Hiroki Yasuma, Susumu Shimizu, Seiji Katakura

Journal of Marine Science and Technology–Taiwan

Many fisheries employ fishing lights to manipulate the behaviors of target fish and to attract them toward the light; however, relatively few long-time observations of fish attraction have been performed in the field. Here, an underwater observation deck was used to examine the differences in the fish-attracting effect of light-emitting diode (LED) lights on the number of attracted fish and on their behavior in the field, using white-edged rockfish as the target species. A total of 604 ± 324, 307 ± 203 and 171 ± 106 white-edged rockfish individuals were attracted to the observation window when it was illuminated with …


Inter-Annual Variability In Growth And Maturation Of The Swordtip Squid Uroteuthis Edulis In Yilan Bay Off Northeastern Taiwan, Jing-Yu Chen, Tzu-Yun Ching, Chih-Shin Chen May 2022

Inter-Annual Variability In Growth And Maturation Of The Swordtip Squid Uroteuthis Edulis In Yilan Bay Off Northeastern Taiwan, Jing-Yu Chen, Tzu-Yun Ching, Chih-Shin Chen

Journal of Marine Science and Technology–Taiwan

The swordtip squid Uroteuthis edulis, distributed in the temperate and tropical neritic waters in the Indo-Pacific region, is a crucial component of marine ecosystems and is a target species of fisheries in the Northwest Pacific. Although studies have elucidated the growth and maturation of the squid in the southern East China Sea (ECS) shelf, few have assessed the population biology of the squid in waters in the vicinity of the southern ECS. We collected samples of swordtip squid from a trawler in Yilan Bay (YLB) between January 2011 and December 2012 to examine the growth and maturation of the squid …


Study On The Improved Radiation Boundary Conditions Based On The Quadratic B-Spline Rankine Panel Method, Ming-Chung Fang, Chun-Hsien Wu May 2022

Study On The Improved Radiation Boundary Conditions Based On The Quadratic B-Spline Rankine Panel Method, Ming-Chung Fang, Chun-Hsien Wu

Journal of Marine Science and Technology–Taiwan

This study presents a higher-order Rankine source method that is based on a biquadratic B-spline scheme with an improved radiation boundary condition. This method solves flow problems under all conditions, where , including the undercritical condition ( < 0.25); this condition is present when a ship undergoes slow translational motion. The proposed method is thus more flexible than the many Rankine-source models in the literature that are applicable only to the overcritical condition ( > 0.25). Specifically, the improved radiation boundary condition is derived from upstream Seto radiation boundary conditions and by incorporating the Rayleigh damping distribution over a free surface; the improved condition is explicit and efficient for solving flow problems. In evaluations, the proposed method yields accurate solutions for unsteady flows, which are produced by an oscillating, translationally moving submerged singularity. The method is also compared …


Sensitive Analysis Of The Static Response Of Compliant Vertical Access Risers, Fuheng Li, Haiyan Guo, Xiaomin Li, Honglu Gu May 2022

Sensitive Analysis Of The Static Response Of Compliant Vertical Access Risers, Fuheng Li, Haiyan Guo, Xiaomin Li, Honglu Gu

Journal of Marine Science and Technology–Taiwan

Compliant vertical access risers (CVARs) are considered as efficient and robust alternative options to achieve cost efficiency and safety. Design uncertainties emerge owing to the limited understanding of the effects of various parameters related to the structural properties and marine loads. In this paper, a reasonable three-dimensional (3D) numerical model of CVAR with internal flow is presented based on the slender rod theory. Accordingly, the finite element method combined with a Newton-Raphson scheme is employed to discretize and solve the equations. A sensitivity analysis is performed to investigate the influence of the structural and external load parameters on the static …


Influence Of Boundary Conditions And Internal Fluid Types On Dynamic Characteristics Of A Deepwater Riser, Lei Guo, Zong-Ming Zhu, Zhong-Jian Pan, Zhi-Ming Guo May 2022

Influence Of Boundary Conditions And Internal Fluid Types On Dynamic Characteristics Of A Deepwater Riser, Lei Guo, Zong-Ming Zhu, Zhong-Jian Pan, Zhi-Ming Guo

Journal of Marine Science and Technology–Taiwan

Deepwater Steel Catenary Riser (DSCR) is the key structure of oil and gas production system in the ocean. To design an optimized DSCR system, the dynamic characteristics of the DSCR are analyzed by setting some different boundary condi-tions and internal fluid types. The main vibration mode of the DSCR is found orthogonal to both mass and stiffness according to the normalization condition of the main mode, and then the regular mode function and the jth order principal stiffness Kpj are obtained. Under different initial conditions, the transverse responses of DSCR represented by regular coordinates under arbitrary excitation are obtained. Then, …


Variance Of Td-Mosaic Dual-Vortex Interactions Between In-Fa And Cempaka (2021) In The North Pacific, Tsorng-Lin Chia, Guang-Yang Pan, Ji-Chyun Liu May 2022

Variance Of Td-Mosaic Dual-Vortex Interactions Between In-Fa And Cempaka (2021) In The North Pacific, Tsorng-Lin Chia, Guang-Yang Pan, Ji-Chyun Liu

Journal of Marine Science and Technology–Taiwan

A study of the different types of dual-vortex interactions or “Fujiwara effects” between two storms is crucial for considerably improving weather forecasts. This study combined remote sensing images, empirical formulas based on the possibility of storm interaction (Liou–Liu formula), and vector addition techniques to accurately analyze In-Fa and Cempaka typhoons and the surrounding weather patterns during the 2021 typhoon season in the North Pacific. Although the distance separating the typhoons In-Fa and Cempaka was 1,800–2,040 km, the influence of middle air flow and a tropical depression (TD) caused a "vector superposition TD-mosaic double-vortex" interaction between the two typhoons. Therefore, this …


Optimal Deployment Of Flood Emergency Response Materials Under Stochastic Demands, Shangyao Yan, Jenn-Rong Lin, Chia-Fu Ku May 2022

Optimal Deployment Of Flood Emergency Response Materials Under Stochastic Demands, Shangyao Yan, Jenn-Rong Lin, Chia-Fu Ku

Journal of Marine Science and Technology–Taiwan

This study aims to develop a planning model for the deployment of flood emergency response materials under stochastic demands. For ease of modeling, a deterministic demand model is first proposed, from which the stochastic model is further extended. These models are used to determine the allocation of materials the transport truck routes and distribution of the stockpiled materials to emergency sites. The models are formulated as multiple integer network flow problems with special side constraints which are characterized as NP-hard in terms of optimization. To solve the complicated stochastic model efficiently, we also develop a solution algorithm based on a …


Graph-Based Heuristic Solution For Placing Distributed Video Processing Applications On Moving Vehicle Clusters, Kanika Sharma, Bernard Butler, Brendan Jennings May 2022

Graph-Based Heuristic Solution For Placing Distributed Video Processing Applications On Moving Vehicle Clusters, Kanika Sharma, Bernard Butler, Brendan Jennings

Articles

Vehicular fog computing (VFC) is envisioned as an extension of cloud and mobile edge computing to utilize the rich sensing and processing resources available in vehicles. We focus on slow-moving cars that spend a significant time in urban traffic congestion as a potential pool of onboard sensors, video cameras, and processing capacity. For leveraging the dynamic network and processing resources, we utilize a stochastic mobility model to select nodes with similar mobility patterns. We then design two distributed applications that are scaled in real-time and placed as multiple instances on selected vehicular fog nodes. We handle the unstable vehicular environment …


Hydrodynamic Limitations To Mangrove Seedling Retention In Subtropical Estuaries, Kelly M. Kibler, Christian Pilato, Linda Walters, Melinda Donnelly, Jyotismita Taye May 2022

Hydrodynamic Limitations To Mangrove Seedling Retention In Subtropical Estuaries, Kelly M. Kibler, Christian Pilato, Linda Walters, Melinda Donnelly, Jyotismita Taye

Flow-biota Interaction and Natural Infrastructure Design

Mangrove forest sustainability hinges upon propagule recruitment and seedling retention. This study evaluates biophysical limitations to mangrove seedling persistence by measuring anchoring force of two mangrove species (Rhizophora mangle and Avicennia germinans). Anchoring force was measured in 362 seedlings via lateral pull-tests administered in mangrove forests of two subtropical estuaries and in laboratory-based experiments. Removal mechanism varied with seedling age: newly-established seedlings failed due to root pull-out while seedlings older than 3 months failed by root breakage. Anchoring force of R. mangle seedlings was consistently and significantly greater than A. germinans (GLM: p = 0.002), however force to …


Scaling And Placing Distributed Services On Vehicle Clusters In Urban Environments, Kanika Sharma, Bernard Butler, Brendan Jennings May 2022

Scaling And Placing Distributed Services On Vehicle Clusters In Urban Environments, Kanika Sharma, Bernard Butler, Brendan Jennings

Articles

Many vehicles spend a significant amount of time in urban traffic congestion. Due to the evolution of autonomous vehicles, driver assistance systems, and in-vehicle entertainment, these vehicles have plentiful computational and communication capacity. How can we deploy data collection and processing tasks on these (slowly) moving vehicles to productively use any spare resources? To answer this question, we study the efficient placement of distributed services on a moving vehicle cluster. We present a macroscopic flow model for an intersection in Dublin, Ireland, using real vehicle density data. We show that such aggregate flows are highly predictable (even though the paths …


Recent Advances In Bone Research 2022 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet May 2022

Recent Advances In Bone Research 2022 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

More and more scientific and engineering applications in bone research make pivotal advances in treating patients with orthopedics issues. Hence, bone research in the 21st century combines, inter alia, biology, chemistry, mathematics, and mechanics with complementary characteristics that help a holistic approach to bone-related pathologies. Nowadays, it is hard to connect new evidence when jargoning and money remain two significant obstacles to sharing knowledge. “Recent Advances In Bone Research” is a free book – no money involved at any stage - that combines the most recent efforts in bone research from several experts with different backgrounds, every expert seeks to …


A Review Of Current Construction Guidelines To Inform The Design Of Rammed Earth Houses In Seismically Active Zones, David Thompson, Charles Augarde, Juan Pablo Osorio May 2022

A Review Of Current Construction Guidelines To Inform The Design Of Rammed Earth Houses In Seismically Active Zones, David Thompson, Charles Augarde, Juan Pablo Osorio

Articles

Sustainability in the materials we use for construction is a prime concern, focusing on reducing the embodied energy and carbon footprints of the materials used. The cement used in concrete products is responsible for a significant proportion of Man's CO2 emissions and its production requires substantial energy input, as do fired clay products. For this reason, products formed from unfired earthen materials are of increasing interest and the current challenges include devising means of robust design for strength and to address durability concerns. One form of earthen construction that employs an in-situ method is rammed earth, and it is a …


Open Hardware In Science: The Benefits Of Open Electronics, Michael Oellermann, Jolle W. Jolles, Diego Ortiz, Rui Seabra, Tobias Wenzel, Hannah Wilson, Richelle L. Tanner May 2022

Open Hardware In Science: The Benefits Of Open Electronics, Michael Oellermann, Jolle W. Jolles, Diego Ortiz, Rui Seabra, Tobias Wenzel, Hannah Wilson, Richelle L. Tanner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Openly shared low-cost electronic hardware applications, known as open electronics, have sparked a new open-source movement, with much untapped potential to advance scientific research. Initially designed to appeal to electronic hobbyists, open electronics have formed a global “maker” community and are increasingly used in science and industry. In this perspective article, we review the current costs and benefits of open electronics for use in scientific research ranging from the experimental to the theoretical sciences. We discuss how user-made electronic applications can help (I) individual researchers, by increasing the customization, efficiency, and scalability of experiments, while improving data quantity and quality; …


Active Testing Of Executive Functions: Toward More Efficient And Equitable Individual Behavioral Modeling, Mariluz Rojo Domingo May 2022

Active Testing Of Executive Functions: Toward More Efficient And Equitable Individual Behavioral Modeling, Mariluz Rojo Domingo

McKelvey School of Engineering Graduate Student Theses & Dissertations

Inferences about executive functions are commonly drawn through serial administration of various individual assessments that often take a long time to complete and cannot capture complex trends across multiple variables. In an attempt to improve upon current methods used to estimate latent brain constructs, this thesis makes two primary contributions to the field of behavioral modeling. First, it brings attention to sequential designs for more efficient diagnostic testing of fluctuations in executive functions with respect to a baseline level. It was shown that a sequential framework was successfully capable of detecting significant differences in cognitive performance more rapidly than conventional …


Design Of An Offner-Chrisp Imaging Spectrometer For A Planetary Fluorescence Instrument, Tristan Wells Carlson May 2022

Design Of An Offner-Chrisp Imaging Spectrometer For A Planetary Fluorescence Instrument, Tristan Wells Carlson

McKelvey School of Engineering Graduate Student Theses & Dissertations

Spectrometers have been an integral part of space exploration in the late 20th and 21st centuries and will continue to provide quantitative measurements to answer exciting questions like, “Is or was there life on other planets?” PERISCOPE, Probe for Exploring Regolith and Ice by Subsurface Classification of Organics, Polycyclic aromatic hydrocarbons, and Elements, is a next generation spectrometer designed to explore icy worlds like Europa. It uses time-resolved ultraviolet (UV) fluorescence spectroscopy, a technique that identifies organic molecules, polycyclic aromatic hydrocarbons (PAH), and rare earth elements (REE). Photon wavelength discrimination is very important for this technique and is accomplished by …


The Role Of Nickel And Brønsted Sites On Ethylene Oligomerization With Ni-H-Beta Catalysts, Gabriel V.S. Seufitelli, Jason J.W. Park, Phuong N. Tran, Anthony Dichiara, Fernando L.P. Resende, Rick Gustafson May 2022

The Role Of Nickel And Brønsted Sites On Ethylene Oligomerization With Ni-H-Beta Catalysts, Gabriel V.S. Seufitelli, Jason J.W. Park, Phuong N. Tran, Anthony Dichiara, Fernando L.P. Resende, Rick Gustafson

Jasper Department of Chemical Engineering Faculty Publications and Presentations

The present work studies the adsorption of ethylene on Ni-H-Beta particles to unravel the roles of nickel and Brønsted sites in the catalytic oligomerization of ethylene. Three models (i.e., two based on the Cossee-Arlman mechanism and one based on the metallacycle mechanism) are examined in terms of the nature of the active sites and the adsorption mechanism involved in the ethylene coordination step. The results are consistent with the participation of two active sites in the formation of [Ni(II)-H]+ Cossee-Arlman centers and also suggest that ethylene dissociates upon adsorption on [Ni(II)-H]+ sites. Further characterization of Ni-H-Beta catalysts prepared at different …


Experimental And Numerical Investigation Of 3d-Printed Viscoelastic Dampers, Mohammed Jaradat May 2022

Experimental And Numerical Investigation Of 3d-Printed Viscoelastic Dampers, Mohammed Jaradat

Civil Engineering ETDs

Elastomeric materials are extensively used in energy dissipation applications to mitigate large lateral displacements and attenuate vibrations. One way of exploiting the capabilities of elastomeric materials is using shear-damping mechanisms such as viscoelastic damping devices (VEDs).

In this research the freedom of design offered by additive manufacturing technology is utilized to produce 3D printed elastomeric parts that act as the viscoelastic layer in an energy damping device. A mechanically interlocked viscoelastic damper (MIVED) with a jigsaw-like interlocking mechanism was designed and manufactured. MIVED is composed of a rigid and soft phase. It operates in two modes, modes I and II, …


Application Of Crowdsourcing And Machine Learning To Predict Sentiments In Textual Student Feedback In Large Computer Science Classes, Robert Kasumba May 2022

Application Of Crowdsourcing And Machine Learning To Predict Sentiments In Textual Student Feedback In Large Computer Science Classes, Robert Kasumba

McKelvey School of Engineering Graduate Student Theses & Dissertations

With the increasing enrollment numbers into popular computer science courses, there is a need to bridge the similarly increasing feedback gap between individual students and course instructors. One way to address this challenge is for instructors to collect feedback from students in form of textual reviews or unit-of-study reflections – however, manually reading these reviews is time-consuming, and self-reported Likert scale responses are noisy. Rule-based approaches to sentiment analysis such as VADER (Valence Aware Dictionary and sEntiment Reasoner) have been used to capture the sentiments conveyed in textual feedback, they however fail to capture contextual differences as many words have …


Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan May 2022

Anti-Amyloid Chimeric Antigen Receptor Macrophages For Alzheimer's Disease Immunotherapy, Qiuyun Pan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s disease is the most common cause of dementia. None of the available drugs can cure the disease. Chimeric Antigen Receptor (CAR) macrophages, because of their phagocytic activity, have potential as a cellular treatment for amyloid aggregation. In this study, we generated an anti-amyloid CAR hematopoietic progenitor cell line. By inducing the progenitor cell line to differentiate into macrophages, we show that the anti-amyloid CAR-Macrophage has enhanced specific phagocytic activity towards amyloid in in vitro experiments. In addition, in ex vivo experiments, anti-amyloid CAR significantly reduces the plaque load on brain slice from APP/PS1 mice when compared to a non-targeted …


Application Of Neural Networks To Predict Patient-Specific Cellular Parameters In Computational Cardiac Models, Chang Hi Lee May 2022

Application Of Neural Networks To Predict Patient-Specific Cellular Parameters In Computational Cardiac Models, Chang Hi Lee

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sudden cardiac death(SCD) is a significant cause of death that accounts for more than 180,000 deaths in the US and 4 million deaths worldwide annually. SCDs are mainly caused by irregular heartbeats called arrhythmias, which are caused by abnormal electrical activity within the heart. Precision medicine, in the form of personalized computational cardiac models of a patient’s heart, can suggest optimal therapies for cardiac arrhythmias. Prior work has used finite element meshes derived from cardiac MRIs to simulate cardiac electrical activity. In this study, I sought to augment this approach by developing a neural network to learn the parameters that …


Optimal Design Of Bacterial Carpets For Fluid Pumping, Minghao W. Rostami, Weifan Liu, Amy Buchmann, Eva Strawbridge, Longhua Zhao May 2022

Optimal Design Of Bacterial Carpets For Fluid Pumping, Minghao W. Rostami, Weifan Liu, Amy Buchmann, Eva Strawbridge, Longhua Zhao

Biology and Medicine Through Mathematics Conference

No abstract provided.