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Articles 34441 - 34470 of 196448

Full-Text Articles in Engineering

Aircraft Engine Particulate Matter Emissions From Sustainable Aviation Fuels: Results From Ground-Based Measurements During The Nasa/Dlr Campaign Eclif2/Nd-Max, Tobias Schripp, Bruce E. Anderson, Uwe Bauder, Bastian Rauch, Joel C. Corbin, Greg J. Smallwood, Prem Lobo, Ewan C. Crosbie, Michael A. Shook, Richard C. Miake-Lye, Zhenhong Yu, Andrew Freedman, Philip D. Whitefield, Claire E. Robinson Oct 2022

Aircraft Engine Particulate Matter Emissions From Sustainable Aviation Fuels: Results From Ground-Based Measurements During The Nasa/Dlr Campaign Eclif2/Nd-Max, Tobias Schripp, Bruce E. Anderson, Uwe Bauder, Bastian Rauch, Joel C. Corbin, Greg J. Smallwood, Prem Lobo, Ewan C. Crosbie, Michael A. Shook, Richard C. Miake-Lye, Zhenhong Yu, Andrew Freedman, Philip D. Whitefield, Claire E. Robinson

Chemistry Faculty Research & Creative Works

The use of alternative jet fuels by commercial aviation has increased substantially in recent years. Beside the reduction of carbon dioxide emission, the use of sustainable aviation fuels (SAF) may have a positive impact on the reduction of particulate emissions. This study summarizes the results from a ground-based measurement activity conducted in January 2018 as part of the ECLIF2/ND-MAX campaign in Ramstein, Germany. Two fossil reference kerosenes and three different blends with the renewable fuel component HEFA-SPK (Hydroprocessed Esters and Fatty Acids Synthetic Paraffinic Kerosene) were burned in an A320 with V2527-A5 engines to investigate the effect of fuel naphthalene/aromatic …


Highly Sensitive Strain Sensor By Utilizing A Tunable Air Reflector And The Vernier Effect, Farhan Mumtaz, Muhammad Roman, Bohong Zhang, Lashari Ghulam Abbas, Muhammad Aqueel Ashraf, Yutang Dai, Jie Huang Oct 2022

Highly Sensitive Strain Sensor By Utilizing A Tunable Air Reflector And The Vernier Effect, Farhan Mumtaz, Muhammad Roman, Bohong Zhang, Lashari Ghulam Abbas, Muhammad Aqueel Ashraf, Yutang Dai, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

A highly sensitive strain sensor based on tunable cascaded Fabry–Perot interferometers (FPIs) is proposed and experimentally demonstrated. Cascaded FPIs consist of a sensing FPI and a reference FPI, which effectively generate the Vernier effect (VE). The sensing FPI comprises a hollow core fiber (HCF) segment sandwiched between single-mode fibers (SMFs), and the reference FPI consists of a tunable air reflector, which is constituted by a computer-programable fiber holding block to adjust the desired cavity length. The simulation results predict the dispersion characteristics of modes carried by HCF. The sensor's parameters are designed to correspond to a narrow bandwidth range, i.e., …


Reinforcement Learning-Based Cooperative Optimal Output Regulation Via Distributed Adaptive Internal Model, Weinan Gao, Mohammed Mynuddin, Donald C. Wunsch, Zhong Ping Jiang Oct 2022

Reinforcement Learning-Based Cooperative Optimal Output Regulation Via Distributed Adaptive Internal Model, Weinan Gao, Mohammed Mynuddin, Donald C. Wunsch, Zhong Ping Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

In this article, a data-driven distributed control method is proposed to solve the cooperative optimal output regulation problem of leader-follower multiagent systems. Different from traditional studies on cooperative output regulation, a distributed adaptive internal model is originally developed, which includes a distributed internal model and a distributed observer to estimate the leader's dynamics. Without relying on the dynamics of multiagent systems, we have proposed two reinforcement learning algorithms, policy iteration and value iteration, to learn the optimal controller through online input and state data, and estimated values of the leader's state. By combining these methods, we have established a basis …


Performance Analytics Of Cloud Networks, Derek Phanekham Oct 2022

Performance Analytics Of Cloud Networks, Derek Phanekham

Computer Science and Engineering Theses and Dissertations

As the world becomes more inter-connected and dependent on the Internet, networks become ever more pervasive, and the stresses placed upon them more demanding. Similarly, the expectations of networks to maintain a high level of performance have also increased. Network performance is highly important to any business that operates online, depends on web traffic, runs any part of their infrastructure in a cloud environment, or even hosts their own network infrastructure. Depending upon the exact nature of a network, whether it be local or wide-area, 10 or 100 Gigabit, it will have distinct performance characteristics and it is important for …


Cascadia Subduction Zone Earthquake Vertical Ground Acceleration Investigation And Potential Impact On Bridges In The Pacific Northwest, Rachel Caroline Bassil Oct 2022

Cascadia Subduction Zone Earthquake Vertical Ground Acceleration Investigation And Potential Impact On Bridges In The Pacific Northwest, Rachel Caroline Bassil

Civil and Environmental Engineering Master's Project Reports

The effects of vertical ground accelerations during subduction zone earthquakes currently are not sufficiently understood. There are numerous case studies and evidence that effects of vertical ground accelerations can significantly impact the performance of bridges during a seismic event, but most previous research has been focused on shallow crustal earthquakes. Current bridge design codes provide little guidance for accounting for vertical ground accelerations in seismic design, in part because additional information is needed about the characteristics of vertical ground motions during Cascadia Subduction Zone (CSZ) earthquakes in the Pacific Northwest.

For this study, recorded seismic data from recent subduction zone …


Deep Learning Prediction Models For Runway Configuration Selection And Taxi Times Based On Surface Weather, Shlok Misra Oct 2022

Deep Learning Prediction Models For Runway Configuration Selection And Taxi Times Based On Surface Weather, Shlok Misra

Doctoral Dissertations and Master's Theses

Growth in air traffic demand in the United States has led to an increase in ground delays at major airports in the nation. Ground delays, including taxi time delays, directly impacts the block time and block fuel for flights which affects the airlines operationally and financially. Additionally, runway configuration selection at an airport significantly impacts the airport capacity, throughput, and delays as it is vital in directing the flow of air traffic in and out of an airport. Runway configuration selection is based on interrelated factors, including weather variables such as wind and visibility, airport facilities such as instrument approach …


Effect Of Passive Clean Air Injection Into The Wake Region Of A Moving Ground Vehicle, Angelos Kaminis Oct 2022

Effect Of Passive Clean Air Injection Into The Wake Region Of A Moving Ground Vehicle, Angelos Kaminis

Doctoral Dissertations and Master's Theses

The wake region on a moving ground vehicle is responsible for 70% of the aerodynamic drag when the speed of 90km/h is achieved. The topic of wake region manipulation has been revisited multiple times and with varying techniques. When manipulating the flow utilizing a fully passive method, pressure drag can be reduced, increasing the overall performance of the vehicle. To ensure high velocity fluid injection, a venturi shaped roof was implemented with an inlet size of 352mm x 12.7mm, and 2 outlets of size 88.011mm x 25.4mm resulting in an area of 4,470.959 for both inlet and outlet to maintain …


Machine Learning And Artificial Intelligence Methods For Cybersecurity Data Within The Aviation Ecosystem, Anna Baron Garcia Oct 2022

Machine Learning And Artificial Intelligence Methods For Cybersecurity Data Within The Aviation Ecosystem, Anna Baron Garcia

Doctoral Dissertations and Master's Theses

Aviation cybersecurity research has proven to be a complex topic due to the intricate nature of the aviation ecosystem. Over the last two decades, research has been centered on isolated modules of the entire aviation systems, and it has lacked the state-of-the-art tools (e.g. ML/AI methods) that other cybersecurity disciplines have leveraged in their fields. Security research in aviation in the last two decades has mainly focused on: (i) reverse engineering avionics and software certification; (ii) communications due to the rising new technologies of Software Defined Radios (SDRs); (iii) networking cybersecurity concerns such as the inter and intra connections of …


A Study Of Ship Airwakes Using Dual Plane Stereoscopic Piv, Guillermo Mazzilli Oct 2022

A Study Of Ship Airwakes Using Dual Plane Stereoscopic Piv, Guillermo Mazzilli

Doctoral Dissertations and Master's Theses

The airwake of a model Simple Frigate Shape 2 (SFS2) was studied in a low-speed wind tunnel. This airwake was measured using a novel time-dependent, dual plane, stereoscopic particle image velocimetry approach. Two flow planes over the flight deck, one parallel and one perpendicular to the free-stream were simultaneously measured. Measurements were carried out over four such pairs of streamwise-spanwise plane combinations. Additionally, the airwake with and without a simulated atmospheric boundary layer (sABL) was studied. The synchronicity of the measurements were taken advantage of to carry out conditional averages of the flow field to isolate and study certain flow …


Machine Learning To Predict Warhead Fragmentation In-Flight Behavior From Static Data, Katharine Larsen Oct 2022

Machine Learning To Predict Warhead Fragmentation In-Flight Behavior From Static Data, Katharine Larsen

Doctoral Dissertations and Master's Theses

Accurate characterization of fragment fly-out properties from high-speed warhead detonations is essential for estimation of collateral damage and lethality for a given weapon. Real warhead dynamic detonation tests are rare, costly, and often unrealizable with current technology, leaving fragmentation experiments limited to static arena tests and numerical simulations. Stereoscopic imaging techniques can now provide static arena tests with time-dependent tracks of individual fragments, each with characteristics such as fragment IDs and their respective position vector. Simulation methods can account for the dynamic case but can exclude relevant dynamics experienced in real-life warhead detonations. This research leverages machine learning methodologies to …


Passive, Self-Healable, Dielectric Elastomers For Structural Health Monitoring, Nicholas Smith Oct 2022

Passive, Self-Healable, Dielectric Elastomers For Structural Health Monitoring, Nicholas Smith

Doctoral Dissertations and Master's Theses

NASA maintains the ability to track a large majority of objects in Earth’s orbit, however lack the ability to track objects smaller than five centimeters in diameter. These untrackable objects represent a significant danger to inflatable structures. This work seeks to synthesize and fabricate a self-healable, passive, dielectric elastomer impact sensor for structural health monitoring on inflatable space structures subject to impact by micrometeoroids and orbital debris. In a setting in which impact repairs can be extremely costly, the implementation of such a technology would not only alert personnel of such an event but would also serve to decrease the …


A Design Flow For Additively Manufactured 3d Metasurface Antennas​, Justin Parkhurst Oct 2022

A Design Flow For Additively Manufactured 3d Metasurface Antennas​, Justin Parkhurst

Doctoral Dissertations and Master's Theses

Metasurface (MTS) antennas are complex arrays consisting of hundreds or thousands of individual elements that each exert their own influence on the performance of the antenna. Due to this, the process of designing and developing a MTS antenna can be intensive in terms of both the time to understand the how these antennas operate and time running calculations that achieve optimal performance. Through the use of automation for geometry creation in ANSYS HFSS, the work involved in making a MTS antenna can be greatly simplified. The overall objective of this thesis is to reduce the burden of constructing a MTS …


Wireless Coupled Feed Structure For Additively Manufactured Conformal Antennas, Blake Roberts Oct 2022

Wireless Coupled Feed Structure For Additively Manufactured Conformal Antennas, Blake Roberts

Doctoral Dissertations and Master's Theses

Due to advancements in additive manufacturing, it is possible to create electromagnetic devices that can be conformally printed directly onto 3D surfaces using conductive inks and dielectric pastes. Instance, the traditional antenna radomes that had the purpose of protecting the antenna on its inside can now become the antenna itself. With the components on the surface of the structure, instead of inside if it, a direct feed line would require cutting through dielectric layers and creating a direct electrical connection, also called vertical interconnect access (VIA). Such interconnects are frequent sources of failures, especially in applications that are subject to …


Assessment Of Iso-Ahola’S Theory Of Tourism Motivation On Willingness To Fly As A Point-To-Point Suborbital Space Tourist, Brian T. Musselman Oct 2022

Assessment Of Iso-Ahola’S Theory Of Tourism Motivation On Willingness To Fly As A Point-To-Point Suborbital Space Tourist, Brian T. Musselman

Doctoral Dissertations and Master's Theses

Suborbital space tourism involves flight in an air vehicle to an altitude exceeding 100 kilometers (62 miles). This altitude is referred to as the Karman Line and the edge of space. Point-to-point space travel is transportation in an air vehicle where the vehicle flies around the earth in space to decrease the time to travel from one point on the earth’s surface to another point on the earth’s surface. The commercial space flight industry has a vision for point-to-point space travel.

The study aimed to assess the influence of the four dimensions of Iso-Ahola’s (1982) theory of tourism motivation on …


Study Of Stochastic Market Clearing Problems In Power Systems With High Renewable Integration, Saumya Sakitha Sashrika Ariyarathne Oct 2022

Study Of Stochastic Market Clearing Problems In Power Systems With High Renewable Integration, Saumya Sakitha Sashrika Ariyarathne

Operations Research and Engineering Management Theses and Dissertations

Integrating large-scale renewable energy resources into the power grid poses several operational and economic problems due to their inherently stochastic nature. The lack of predictability of renewable outputs deteriorates the power grid’s reliability. The power system operators have recognized this need to account for uncertainty in making operational decisions and forming electricity pricing. In this regard, this dissertation studies three aspects that aid large-scale renewable integration into power systems. 1. We develop a nonparametric change point-based statistical model to generate scenarios that accurately capture the renewable generation stochastic processes; 2. We design new pricing mechanisms derived from alternative stochastic programming …


Heuristics For Capacity Allocation And Queue Assignment In Congested Service Systems With Stochastic Customer Demand And Immobile Servers, Adam Colley Oct 2022

Heuristics For Capacity Allocation And Queue Assignment In Congested Service Systems With Stochastic Customer Demand And Immobile Servers, Adam Colley

Operations Research and Engineering Management Theses and Dissertations

We propose easy-to-implement heuristics for a problem referred to in the literature as the facility location problem with immobile servers, stochastic demand, and congestion, or the service system design problem. The problem is typically posed as one of allocating capacity to a set of M/M/1 queues to which customers with stochastic demand are assigned with the objective of minimizing a cost function composed of a fixed capacity-acquisition cost, a variable customer-assignment cost, and an expected-waiting-time cost. The expected-waiting-time cost results in a non-linear term in the objective function of the standard binary programming formulation of the problem. Thus, the solution …


Design And Fabrication Of A Low-Cost And Programmable Dip Coating Machine, Christy Dunlap, Skylar Featherstone, Matthew Smith, Man Vu, Amanda Williams, Jason Bailey, Han Hu Oct 2022

Design And Fabrication Of A Low-Cost And Programmable Dip Coating Machine, Christy Dunlap, Skylar Featherstone, Matthew Smith, Man Vu, Amanda Williams, Jason Bailey, Han Hu

Mechanical Engineering Faculty Publications and Presentations

Dip coaters provide a compact device that can be used to obtain uniform and consistent coatings on a substrate. This article describes a less costly dip coater design with similar specifications to other dip coaters. The machine consists of a NEMA 23 stepper motor, touch screen display, and acrylic housing to protect the substrate from dust. The machine is programmed using Arduino IDE, allowing for easy changes to be made. The small size of the dip coater makes it ideal for use in labs. The majority of the components require no alterations after purchase, allowing for easy replacements and construction.


Increased Panel Height Enhances Cooling For Photovoltaic Solar Farms, Sarah E. Smith, Bianca Viggiano, Naseem Ali, Timothy J. Silverman, Martin Obligado, Marc Calaf, Raul Bayoan Cal Oct 2022

Increased Panel Height Enhances Cooling For Photovoltaic Solar Farms, Sarah E. Smith, Bianca Viggiano, Naseem Ali, Timothy J. Silverman, Martin Obligado, Marc Calaf, Raul Bayoan Cal

Mechanical and Materials Engineering Faculty Publications and Presentations

Solar photovoltaic (PV) systems suffer substantial efficiency loss due to environmental and internal heating. However, increasing the canopy height of these systems promotes surface heat transfer and boosts production. This work represents the first wind tunnel experiments to explore this concept in terms of array flow behavior and relative convective heat transfer, comparing model solar arrays of varied height arrangements - a nominal height, extended height, and a staggered height configuration. Analyses of surface thermocouple data show average Nusselt number (𝑁𝑢) to increase with array elevation, where panel convection at double height improved up to 1.88 times that of the …


Metaversekg: Knowledge Graph For Engineering And Design Application In Industrial Metaverse, Utkarshani Jaimini, Tongtao Zhang, Georgia Olympia Brikis Oct 2022

Metaversekg: Knowledge Graph For Engineering And Design Application In Industrial Metaverse, Utkarshani Jaimini, Tongtao Zhang, Georgia Olympia Brikis

Publications

While the term Metaverse was first coined by the author Neal Stephenson in 1992 in his science fiction novel “Snow Crash”, today the vision of an integrated virtual world is becoming a reality across different sectors. Applications in gaming and consumer products are gaining traction, industrial metaverse applications are, still in their early stages of development with one of the challenges being interoperability across various metaverse development platforms and existing software tools. In this work we propose the use of a knowledge graph based semantic data exchange layer, the Metaverse Knowledge Graph, to enable seamless transfer of information across platforms. …


Perovskite-Surface-Confined Grain Growth For High-Performance Perovskite Solar Cells, Sajid Sajid, Salem Alzahmi, Imen Ben Salem, Ihab M. Obaidat Oct 2022

Perovskite-Surface-Confined Grain Growth For High-Performance Perovskite Solar Cells, Sajid Sajid, Salem Alzahmi, Imen Ben Salem, Ihab M. Obaidat

All Works

The conventional post-annealing (CPA) process is frequently employed and regarded a crucial step for high-quality perovskite thin-films. However, most researchers end up with unwanted characteristics because controlling the evaporation rate of perovskite precursor solvents during heat treatment is difficult. Most perovskite thin-films result in rough surfaces with pinholes and small grains with multiple boundaries, if the evaporation of precursor solvents is not controlled in a timely manner, which negatively affects the performance of perovskite solar cells (PSCs). Here, we present a surface-confined post-annealing (SCPA) approach for controlling the evaporation of perovskite precursor solvents and promoting crystallinity, homogeneity, and surface morphology …


Multi-Bsm: An Anomaly Detection And Position Falsification Attack Mitigation Approach In Connected Vehicles, Zouheir Trabelsi, Syed Sarmad Shah, Kadhim Hayawi Oct 2022

Multi-Bsm: An Anomaly Detection And Position Falsification Attack Mitigation Approach In Connected Vehicles, Zouheir Trabelsi, Syed Sarmad Shah, Kadhim Hayawi

All Works

With the dawn of the emerging technologies in the field of vehicular environment, connected vehicles are advancing at a rapid speed. The advancement of such technologies helps people daily, whether it is to reach from one place to another, avoid traffic, or prevent any hazardous incident from occurring. Safety is one of the main concerns regarding the vehicular environment when it comes to developing applications for connected vehicles. Connected vehicles depend on messages known as basic safety messages (BSMs) that are repeatedly broadcast in their communication range in order to obtain information regarding their surroundings. Different kinds of attacks can …


Achieving Sustainability In Urban Transit And High-Occupancy Vehicle Systems Through Emerging Technologies And Operations, Ruixiao Sun Oct 2022

Achieving Sustainability In Urban Transit And High-Occupancy Vehicle Systems Through Emerging Technologies And Operations, Ruixiao Sun

Theses and Dissertations

It is critical to reduce road transportation emissions, as it is the major source contributing to greenhouse gas emissions (GHGs) and air pollution. However, the increasing travel demand due to the rise of population and economy makes the task challenging. Mathematically, road transportation emissions can be minimized in the manner of reducing total vehicle miles traveled (VMT) and lowering vehicle emission rate. Many strategies have been proven viable for achieving transportation sustainability. For example, the total VMT can be reduced by switching low-occupancy transportation modes (i.e., driving alone) to high-occupancy transportation modes (i.e., public transit, ridesharing). The development of alternative-fuel …


Applications Of Laser Liftoff Technique For Wide Bandgap Power And Flexible Electronics, Md Didarul Alam Oct 2022

Applications Of Laser Liftoff Technique For Wide Bandgap Power And Flexible Electronics, Md Didarul Alam

Theses and Dissertations

Wide bandgap (WBG) AlGaN/GaN and ultrawide bandgap (UWBG) AlGaN/AlGaN III-nitride high electron mobility transistors (HEMTs) have come a long way since their initial demonstration and are desired for a multitude of applications in deep-scaled high-frequency, high-voltage, high-current, and high-temperature power electronics. Although AlGaN/GaN HEMTs have recently become state-of-the-art in consumer electronics chargers and amplifiers, the performance of the devices is limited by severe self-heating which significantly reduce their efficacy in demanding applications that require high-current density. One strategy to reduce this self-heating effect in GaN HEMTs is to use high thermal conductivity SiC or bulk AlN substrates. While this approach …


A Symmetric Matrix-Aided Mimo To Improve Reliability For Maritime Visible Light Communications, You Zhang, Yan Feng, Lin Zhang, Zhiqiang Wu Oct 2022

A Symmetric Matrix-Aided Mimo To Improve Reliability For Maritime Visible Light Communications, You Zhang, Yan Feng, Lin Zhang, Zhiqiang Wu

Electrical Engineering Faculty Publications

Turbulence in natural environments affects the reliability of communication. In this paper, we propose a symmetric matrix-assisted multiple-input multiple-output (MIMO) maritime visible light communication (VLC) system to confront turbulence and improve reliability. In our design, by exploiting the repeatability of elements in the symmetric matrix, the matrix can expand the Euclidean distance between signals and effectively restrains the interference between signals, thus improving the reliability of maritime VLC systems. In addition, we derive the theoretical symbol error rate (SER) of the proposed scheme. Then, simulation results are provided to validate the theoretical SER. In addition, the SER performances of the …


Me-Em Enewsbrief, September 2022, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University Oct 2022

Me-Em Enewsbrief, September 2022, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.


Big Lagoon Sea Level Rise, Kyra Cohen, Malia Seeley, Dustin Helliwell, Albert Wolff Oct 2022

Big Lagoon Sea Level Rise, Kyra Cohen, Malia Seeley, Dustin Helliwell, Albert Wolff

Student Projects

Cal Poly Humboldt Environmental Resources Engineering Senior Capstone.

The California Department of Transportation (Caltrans) is highly concerned sea level rise (SLR), due to climate change and the potential negative impacts on the California transportation system. SLR is especially important for routes constructed at low elevations and those immediately adjacent to the coast where SLR is one of the largest threats to the transportation system along the coast. Rising sea levels are expected to disrupt the daily lives of Californians, specifically the coastal economies, which increases the risk to public safety and contributes to the decline of ecosystems that are vital …


Sea Level Rise Analysis: High-Importance Access Road Protection, Max Alvin, Taylor Goodwyn, Karly Johnson, Pedro Valverde Oct 2022

Sea Level Rise Analysis: High-Importance Access Road Protection, Max Alvin, Taylor Goodwyn, Karly Johnson, Pedro Valverde

Student Projects

Cal Poly Humboldt Environmental Resources Engineering Senior Capstone.

This report provides an analysis of design alternatives and ultimately a preferred design to ensure the longevity of Highway 101 near Orick, CA which is under threat of sea level rise (SLR). Highway 101 is the main transportation corridor for communities stretching from Arcata to Crescent City, California. Caltrans provided an area of interest along Highway 101 just southwest of Orick, between mile markers 119.58 and 119.92. The project area of interest is illustrated below in Figure ES-1. This stretch of Highway 101 borders low lying pastures and Redwood Creek's historic estuary. …


Impact Of Pipe Material On Microbial Communities In Biofilm Samples From Full-Scale Drinking Water Distribution Systems, San Marie Victoria Thomson Oct 2022

Impact Of Pipe Material On Microbial Communities In Biofilm Samples From Full-Scale Drinking Water Distribution Systems, San Marie Victoria Thomson

Master's Theses (2009 -)

The drinking water distribution system (DWDS) provides a habitat particularly supportive to biofilm-forming bacteria that can attach to pipe walls. These biofilms comprise the majority of bacteria in the DWDS, yet they have been understudied with respect to the pipe material on which they form. Biofilms can accelerate disinfectant decay, promote corrosion of pipes, and harbor opportunistic pathogens (OPs). The choice of pipe material could have a long-lasting effect on the characteristics of the biofilms formed in DWDSs. In this study, the impact of pipe material on biofilms residing in full-scale drinking water pipes was investigated by obtaining biofilm samples …


Development Of An In Vitro Model To Assess Endothelial Dysfunction From Coarctation Of The Aorta, Dylan James Schock Oct 2022

Development Of An In Vitro Model To Assess Endothelial Dysfunction From Coarctation Of The Aorta, Dylan James Schock

Master's Theses (2009 -)

Coarctation of the aorta (CoA) is a common congenital heart defect characterized by a stenosis of the descending thoracic aorta. Surgical treatment can alleviate the stenosis and restore physiologic blood flow; however, patients frequently develop cardiovascular morbidity with hypertension (HTN) being most common. Identifying the mechanisms involved with the onset of HTN in CoA patients is difficult due to confounding factors including the severity of coarctation, age of correction, and general lifestyle factors. To account for the variability seen in humans, a rabbit model of CoA and correction was developed previously. Microarray analysis of aortic samples from the model showed …


Comparison Of 3d Bio-Printed Ipsc-Cms Derived From Healthy Donors And Patients With Hlhs, Wei He Oct 2022

Comparison Of 3d Bio-Printed Ipsc-Cms Derived From Healthy Donors And Patients With Hlhs, Wei He

Master's Theses (2009 -)

Hypoplastic left heart syndrome (HLHS) is an extremely severe form of congenital heart disease, but current treatments are not adequate. In order to find more effective treatments, we need to reproduce in vitro the physiological characteristics of cardiomyocytes associated with HLHS. Such a tissue model could be of great help to current medical research, and 3D printing technology is an effective tool for this purpose. We print layer-by-layer cardiomyocytes from both healthy and HLHS patients with laminin-based bioink to form a three-dimensional model. With our 3D cell culture technology, this model can simulate the growth conditions of cardiomyocytes in vivo. …