Engineering Commons^™

Recombinant Human Plasma Gelsolin Reverses Increased Permeability Of The Blood-Brain Barrier Induced By The Spike Protein Of The Sars-Cov-2 Virus., Łukasz Suprewicz, Kiet A Tran, Ewelina Piktel, Krzysztof Fiedoruk, Paul A Janmey, Peter Galie, Robert Bucki

Henry M. Rowan College of Engineering Departmental Research

BACKGROUND: Plasma gelsolin (pGSN) is an important part of the blood actin buffer that prevents negative consequences of possible F-actin deposition in the microcirculation and has various functions during host immune response. Recent reports reveal that severe COVID-19 correlates with reduced levels of pGSN. Therefore, using an in vitro system, we investigated whether pGSN could attenuate increased permeability of the blood-brain barrier (BBB) during its exposure to the portion of the SARS-CoV-2 spike protein containing the receptor binding domain (S1 subunit).

MATERIALS AND METHODS: Two- and three-dimensional models of the human BBB were constructed using the human cerebral microvascular endothelial …

Transcriptomic Analysis Of A 3d Blood-Brain Barrier Model Exposed To Disturbed Fluid Flow., Nesrine Bouhrira, Brandon J Deore, Kiet A Tran, Peter Galie

Henry M. Rowan College of Engineering Departmental Research

Cerebral aneurysms are more likely to form at bifurcations in the vasculature, where disturbed fluid is prevalent due to flow separation at sufficiently high Reynolds numbers. While previous studies have demonstrated that altered shear stress exerted by disturbed flow disrupts endothelial tight junctions, less is known about how these flow regimes alter gene expression in endothelial cells lining the blood-brain barrier. Specifically, the effect of disturbed flow on expression of genes associated with cell-cell and cell-matrix interaction, which likely mediate aneurysm formation, remains unclear. RNA sequencing of immortalized cerebral endothelial cells isolated from the lumen of a 3D blood-brain barrier …

Modeling, Control, And Operation Of A Grid-Tied Solar Photovoltaic Inverter In Unbalanced Conditions, Abdulhakim Alsaif

USF Tampa Graduate Theses and Dissertations

With the increasing penetration of inverter-based resources (IBRs) integrated into powersystem grids as well as in microgrids (MGs), operational challenges and stability issues have been identified by the industry. In the last few years, solar Photovoltaic (PV) farm plants were allowed to be disconnected (isolated from the grid) during abnormal operation conditions to not only avoid stability issues but also to protect any damage to the solar PV inverter from such overcurrent or overvoltage. Most solar PV inverters operate in a conventional grid-following (GFL) control, where unbalanced operation becomes a critical issue. This control scheme regulates only positive sequence currents. …

Aviation Supply And Demand In The São Paulo And Rio De Janeiro Systems Evolution: An Exploratory Study, Leila Halawi, Bruno De Paula Balan, Renan Cipriano Da Cunha, Maria Claudia Ferreira Da Cunha

Publications

Aim/purpose – Multiple factors affect a passenger’s origin and destination airport choice. This study explores some of the leading indicators associated with performance in cities with more than one airport. Two important Multi-Airport Systems (MAS) in Brazil were the object of this study: São Paulo (Congonhas and Guarulhos) and Rio de Janeiro (Santos Dumont and Galeão), the most significant demand-generating centers in the country and the most critical distribution centers of flights from South America.

Design/methodology/approach – Using public databases presenting the evolution of supply and demand from 2013 to 2018, the evolution of flights, and the sales by airlines …

Securing The Nation’S Critical Infrastructures 1st Edition - Chapter 8, Stanley Mierzwa, Lauren Spath

Center for Cybersecurity

When you consider industries that were reinvented in recent history, you will find companies that continued to morph and remain relevant and viable and those who started off valid and in favor, but alas, perhaps didn’t make the sustainable cut. Consider, for example, Blockbuster Video, they were at the forefront of providing the legal rental of movies using physical media, such as a tape or DVD. They had the opportunity to transition from physical movie rentals to online—they had a customer base and name recognition. Do you see any Blockbuster Video stores around? Chances are you do not, and this …

Bringing Science Into The Classroom With Lora Radiotechnology, Robert J. Twiggs

Robert "Bob" Twiggs STEM Education Collection

A PowerPoint Presentation created by Professor Bob Twiggs titled "Bringing Science Into the Classroom With LoRa Radiotechnology" from November 24, 2022.

Structural Health Assessment Of Pavement Sections In The Southern Central United States Using Fwd Parameters, Nitish R. Bastola, Mena Souliman, Samer Dessouky, Raja Daoud

Civil Engineering Faculty Publications and Presentations

Various Departments of Transportation in the South-Central States and elsewhere have made extensive use of the Non-Destructive Testing (NDT) surface deflection bowl data. The falling weight deflectometer (FWD) test is a popular NDT-based test used by transportation authorities to evaluate the performance of flexible pavement. Nevertheless, it is rare to develop a method for evaluating pavement sections using FWD data from all sensors. There is a constant demand for DOTs and highway agencies to have a streamlined approach that can be applied directly to their databases. This research focuses on extending and verifying the concept of previously published area ratio …

Instructional Systems Design And The Diffusion And Adoption Of Technology: (Volume 1), Miguel Ramlatchan (Author & Editor), Mark Parsons (Author), Meghan Soldani (Author), Josie Joswick Mendoza (Author), Maria Satre (Author), Brittany Spitz (Author), Jasmine Bundy (Author), Amanda Kline (Author)

Distance Learning Faculty & Staff Books

Instructional designers, instructional systems designers, and other educational technologists are, by their nature, innovators. These professionals apply and extend the applied science of learning, systems, communication, and instructional design theory to help students learn. Technology in some capacity is used to make the connections between subject matter experts, teachers, instructors, and their learners. It is common for instructional designers to seek new tools, techniques, and innovations for the improvement of learning, access, quality, and student satisfaction. However, the adoption and diffusion of new educational technology and innovation is a complex process that depends on many variables. Understanding these processes and …

In Vitro Models For The Study Of Liver Biology And Diseases: Advances And Limitations, Savneet Kaur, Srivatsan Kidambi, Martí Ortega-Ribera, Le Thi Thanh Thuy, Natalia Nieto, Victoria C. Cogger, Wei-Fen Xie, Frank Tacke, Jordi Gracia-Sancho

Department of Chemical and Biomolecular Engineering: Faculty Publications

In vitro models of liver (patho)physiology, new technologies, and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multicellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of …

Gen. Thomas P. Stafford Looks At The Display In The Hallway At Stafford Elementary, Weatherford Daily News

Articles

Gen. Thomas P. Stafford looks at the display in the hallway at Stafford Elementary, which is named in his honor. His two sons, Stas, right, and Michael look on.

Unless stated otherwise within this repository collection, all materials are shared under the following Creative Commons license: [Creative Commons Attribution-NonCommercial 4.0 International License].

Gen. Thomas P. Stafford Elementary School And Weatherford Stafford Airport Terminal Dedications November 21 & 22, 2022, Weatherford Daily News

Articles

A collection of photos from the dedications of Stafford Elementary and Stafford Airport Terminal, seen in the November 23rd, 2022 issue of the Weatherford Daily News.

Unless stated otherwise within this repository collection, all materials are shared under the following Creative Commons license: [Creative Commons Attribution-NonCommercial 4.0 International License].

Exosomes Derived From Differentiated Human Admsc With The Schwann Cell Phenotype Modulate Peripheral Nerve-Related Cellular Functions, Bo Liu, Yunfan Kong, Wen Shi, Mitchell Kuss, Ke Liao, Guoku Hu, Peng Xiao, Jagadesan Sankarasubramanian, Chittibabu Guda, Xinglong Wang, Yuguo Lei, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden. Exosomes, especially those derived from mesenchymal stem cells (MSCs), are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration. In this study, we reported the differentiation of human adipose derived MSCs (hADMSCs) towards the Schwann cell (SC) phenotype (hADMSC-SCs) and then isolated exosomes from hADMSCs with and without differentiation (i.e., dExo vs uExo). We assessed and compared the effects of uExo and dExo on antioxidative, angiogenic, antiinflammatory, and axon growth promoting properties by using various peripheral nerve-related cells. …

A Novel Voc Breath Tracer Method To Evaluate Indoor Respiratory Exposures In The Near- And Far-Fields; Implications For The Spread Of Respiratory Viruses, Hooman Parhizkar, Mark Fretz, Aurelie Laguerre, Jason Stenson, Richard Corsi, Kevin Van Den Wymelenberg, Elliott T. Gall

Mechanical and Materials Engineering Faculty Publications and Presentations

Background

Several studies suggest that far-field transmission (>6 ft) explains a significant number of COVID-19 superspreading outbreaks.

Objective

Therefore, quantifying the ratio of near- and far-field exposure to emissions from a source is key to better understanding human-to-human airborne infectious disease transmission and associated risks.

Methods

In this study, we used an environmentally-controlled chamber to measure volatile organic compounds (VOCs) released from a healthy participant who consumed breath mints, which contained unique tracer compounds. Tracer measurements were made at 0.76 m (2.5 ft), 1.52 m (5 ft), 2.28 m (7.5 ft) from the participant, as well as in the …

Bulk Glass As Compressive Reinforcement In Structural Elements, John Cotter

USF Tampa Graduate Theses and Dissertations

All composites are formulations of materials that allow for the improvement of material properties by compositing materials with differing properties. For example, straw, which has a low compression strength and stiffness but relatively high tensile stiffness, composites well with clay, which has a high compression stiffness and low tensile strength, to create a material that utilizes a clay base with straw to greatly improve the strength of clay. In general, the most economical composites are those that combine a low-cost binder, or matrix, with higher strength reinforcing materials.

Contrary to popular knowledge, bulk glass is an exceedingly strong material when …

Predictions Of Household Water Affordability Under Conditions Of Climate Change, Demographic Growth, And Fresh Groundwater Depletion In A Southwest Us City Indicate Increasing Burdens On The Poor, Josiah M. Heyman, Alex S. Mayer, Jessica Alger

Michigan Tech Publications, Part 1

Reduced river flows and groundwater depletion as a result of climate change and population growth have increased the effort and difficulty accessing and processing water. In turn, residential water costs from municipal utilities are predicted to rise to unaffordable rates for poor residential water customers. Building on a regional conjunctive use model with future climate scenarios and 50-year future water supply plans, our study communicates the effects of climate change on poor people in El Paso, Texas, as water becomes more difficult and expensive to obtain in future years. Four scenarios for future water supply and future water costs were …

The Hole Sealing Technology Of Solid-Liquid Materials With Three Pluggings And Two Injections For Gas Extraction Hole In The Coal Mine, Shiyao Yu, Xianbo Su, Jinxing Song, Qian Wang, Zhenjiang You

Research outputs 2022 to 2026

The sealing quality of the gas extraction holes determines the extracted gas concentration. Based on this, the paper reveals the basic principle of hole sealing by analyzing the gas leakage mechanism of the borehole. The hole sealing technology of solid-liquid materials with three pluggings and two injections for the gas extraction hole is proposed, and the hole sealing device and material are developed. Through testing the granularity distribution of the solid material, as well as the surface tension and contact angle of the slurry, the hole sealing material that can meet the requirements of accessible, sticky, and anti-deformation is selected. …

Predicting The Stability Of Open Stopes Using Machine Learning, Alicja Szmigiel, Derek B. Apel

Journal of Sustainable Mining

The Mathews stability graph method was presented for the first time in 1980. This method was developed to assess the stability of open stopes in different underground conditions, and it has an impact on evaluating the safety of underground excavations. With the development of technology and growing experience in applying computer sciences in various research disciplines, mining engineering could significantly benefit by using Machine Learning. Applying those ML algorithms to predict the stability of open stopes in underground excavations is a new approach that could replace the original graph method and should be investigated. In this research, a Potvin database …

Designing And Cnc Machine Valve Sub-Plates And Quick Mounts For Hydraulic Power Training Systems, Connor Maxam

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Business and Technology at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Science by Connor Maxam on November 22, 2022.

Dynamic Study Of Inverter-Based Resources In Weak Grids, Zhengyu Wang

USF Tampa Graduate Theses and Dissertations

As the main technology behind renewable energy resources, such as solar PV and wind turbines, inverter-based generation penetration is increasing aggressively. Besides the congestion concerns when interconnecting a large-scale inverter-based resource (IBR) into the power grid, stability issues are commonly existing. The stability events occur more frequently when the resources are in remote area because the transmission line is long and grid strength is weak. One of the most representative and widely observed phenomena of IBR instability is low-frequency oscillation. And this dissertation focuses on investigating the low-frequency oscillations of IBR in weak grids.

The main objectives of the investigation …

Wind Tunnel Research, Dynamics, And Scaling For Wind Energy, Majid Bastankhah, Raul Bayoan Cal, Nicholas Hamilton

Mechanical and Materials Engineering Faculty Publications and Presentations

The interaction of wind turbines with turbulent atmospheric boundary layer (ABL) flows represents a complex multi-scale problem that spans several orders of magnitudes of spatial and temporal scales. These scales range from the interactions of large wind farms with the ABL (on the order of tens of kilometers) to the small length scale of the wind turbine blade boundary layer (order of a millimeter). Detailed studies of multi-scale wind energy aerodynamics are timely and vital to maximize the efficiency of current and future wind energy projects, be they onshore, bottom-fixed offshore, or floating offshore. Among different research modalities, wind tunnel …

Profess 12: Project Report Pr1: The Global View On Skills Needed For Sustainability, Una Beagon, Margaret Morgan, Ruchita Jani, Brian Bowe

Reports

Engineers of the future must be technical experts, able to solve problems in an integrated way, a systems thinker, a holistic thinker, a critical thinker, someone who can work with diverse people in multidisciplinary teams. Excellent communication skills and being able to work across cultural boundaries are key components of the engineers toolbox. They must also have a good ethical conscience, grit, adaptability and the ability to challenge the status quo. Finally, the engineer of the future must have sustainability-friendly attitudes and values and a focus on social responsibility so that they can do their part to achieve the SDGs. …

Cocm: Co-Occurrence-Based Consistency Matching In Domain-Adaptive Segmentation, Siyu Zhu, Yingjie Tian, Fenfen Zhou, Kunlong Bai, Xiaoyu Song

Electrical and Computer Engineering Faculty Publications and Presentations

This paper focuses on domain adaptation in a semantic segmentation task. Traditional methods regard the source domain and the target domain as a whole, and the image matching is determined by random seeds, leading to a low degree of consistency matching between domains and interfering with the reduction in the domain gap. Therefore, we designed a two-step, three-level cascaded domain consistency matching strategy—co-occurrence-based consistency matching (COCM)—in which the two steps are: Step 1, in which we design a matching strategy from the perspective of category existence and filter the sub-image set with the highest degree of matching from the image …

Quantifying A 21-Year Surface Water And Groundwater Interaction In A Ridge And Valley Lake Environment Using A Highly Constrained Modeling Approach, Richard T. Bowers Jr.

USF Tampa Graduate Theses and Dissertations

Karst lakes are ubiquitous in ridge terrain settings in limestone aquifer coastal plain environments. In west-central Florida, these lakes are frequently connected to the Upper Floridan aquifer and have unique aquifer recharge characteristics. They have been selectively studied because they commonly have no or very limited surface water discharge and limited drainage areas, have appreciable surface water and groundwater interaction and leak to the deep aquifer. An innovative modeling approach was developed to collectively understand and more precisely quantify this vertical leakage, both from a lake-specific and regional water budget standpoint, for a 21-year study period (2000-2020). A unique, calibrated …

Print3d, A Service-Learning Project For Improving Visually Impaired Accessibility Through Educational 3d Printing, Oscar R. Lozano

Journal of Pre-College Engineering Education Research (J-PEER)

Well-executed service-learning projects are a high-value educational element. However, these projects commonly focus on overused topics and unbalanced executions which can produce the opposite effect to that desired when working with groups of people with functional diversity. PRINT3D is a service-learning project aimed at improving accessibility for people with visual disabilities while helping primary and secondary school students learn basic engineering skills through 3D design and printing. Under the support of the European Erasmus+ Programme, this project brought together nongovernmental organizations, teacher professional development centers, business enterprises, and educational centers to collaborate for two school years. The project activities aimed …

Metascriptura: A General Data Provenance Framework, Maria Joseph Israel

Engineering Ph.D. Theses

Digital technology makes it easy to generate and distribute large volumes of data. However, it has also complicated the process of verifying and validating sources of data and their derivatives risking obfuscation of truth amidst the deluge of data. To address this issue, I trace and develop an approach based on data provenance tracking. Specifically, I make it possible to deep trace the origins and lineages of data, by applying state-of-the-art data provenance technologies, which I extend beyond traditional data provenance applications. In this dissertation, I demonstrate that with the right data infrastructure it is feasible to grant greater agency …

Stochastic Models For Resilience Assessment And Improvement, Weimar Ardila Rueda

USF Tampa Graduate Theses and Dissertations

Resilience refers to the ability of a system to absorb and mitigate the impact of potential disruptions and return to normal operational conditions. The above notion of resilience allows us to distinguish two stages in a system's post-disruption response, the absorptive dimension and the recovery dimension. The absorptive dimension is related to a system's robustness and capacity to mitigate initial loss posterior to a disruption. Meanwhile, the recovery dimension is the system's rapidity to return and reach an acceptable level of functionality after the disruption occurrence.

A social-physical (SP) system's post-disruption response is related to its resilience capacity so building …

Aldosterone Treatment Protects Connexin 30 And 43 Expression For Age-Related Hearing Loss, Jennifer A. Pineros Valencia

USF Tampa Graduate Theses and Dissertations

Age-related hearing loss (ARHL), also known as presbycusis, is the number one communication disorder affecting our aged population. Connexin proteins are essential for intercellular communication throughout the human body. Mutations in connexin genes have been linked to human syndromic and nonsyndromic deafness; thus, we hypothesize changes in connexin gene and protein expression with age may be involved in the development of ARHL. In our current study, connexin mRNA gene expression for CBA/CaJ mice at different age points were examined and correlations were analyzed between the changes in gene expression and functional hearing measures, such as ABRs and DPOAEs. Moreover, we …

Spacecraft Systems & Navigation, Christopher Vanacore

Student Works

This textbook is steered towards higher educational course entailed in Commercial Space Operations. This textbook will be covering in detail Orbital Satellites, and Spacecraft. These topics are discussed according to their application, design, and environment. The power system, shielding and communication systems are reviewed along with their missions, space, environment and limitations. Any vehicle, whether manned or unmanned, intended for space travel is a spacecraft. A spacecraft's required systems and equipment depend on the information it will acquire and the tasks it will perform. Although their levels of sophistication vary widely, they re all subject to the harsh conditions of …

Applying Biomimetic Passive Dynamics To A Quadruped Robot Leg, Emma Krnacik

Dissertations and Theses

The study of synthetic nervous systems is an emerging field within biomimetic robotics as an alternative to more classic control techniques. As the modeling of these nervous systems becomes more accurate, it is important to note that the nervous system and physical system co-evolved and continue to operate in an interdependent fashion. Many legged robots, including the existing quadruped in the AARL, have leg systems that may have similar geometrical properties to that of a mammal, but have significantly different dynamic properties. This paper presents a method for designing a limb so that the passive dynamics more accurately represent that …

Passive Cooling Analysis Of An Electronic Chipset Using Nanoparticles And Metal-Foam Composite Pcm: An Experimental Study, Faisal Hassan, Abid Hussain, Furqan Jamil, Adeel Arshad, Hafiz Muhammad Ali

Research outputs 2022 to 2026

Thermal management of electronic components is critical for long-term reliability and continuous operation, as the over-heating of electronic equipment leads to decrement in performance. The novelty of the current experimental study is to investigate the passive cooling of electronic equipment, by using nano-enriched phase change material (NEPCM) with copper foam having porosity of 97 %. The phase change material of PT-58 was used with graphene nanoplatelets (GNPs) and magnesium oxide (MgO) nanoparticles (NPs), having concentrations of 0.01 wt. % and 0.02 wt. %. Three power levels of 8 W, 16 W, and 24 W, with corresponding heating inputs of 0.77 …