Quantification Of Tumor Biophysical Heterogeneity Through Mechanical And Ultrastructural Analysis., Bradley James Mahaffey

Electronic Theses and Dissertations

Glioblastoma (GBM) is a highly invasive, aggressive brain cancer that carries a median survival of 15 months. This poor prognosis is due, in part, to its resistance to standard therapeutic intervention. Recent studies have demonstrated that tumor heterogeneity plays a critical role in facilitation therapy resistance by mediating tumor adaptation through microenvironmental cues. Efforts to describe these microenvironmental differences may aid in the development of strategies to combat resistance. GBM can be separated into two distinct regions – a core and a rim, which are thought to drive specific aspects of tumor evolution. The core is proliferative as evidenced by …

Automated Usability Evaluation Utilizing Log Files And Data Mining Techniques., Sima Shafaei

Electronic Theses and Dissertations

Usability evaluation is one of the essential aspects of software production. This evaluation should be done during the entire life cycle of a software application, from pre-production to production and post-production. However, the collection and evaluation of usability data can be a very challenging, time-consuming, and expensive task to be conducted manually, particularly for certain types of products and working conditions. These challenges may include the need to recruit participants fully engage and motivate them during evaluation, and factor in environmental conditions. Other challenges may include collecting data in real-world environments, especially when the users are geographically dispersed, minimizing evaluator …

Investigating Mems Devices In Flow Conditions Relevant To Flow-Through Systems., Mohammad Shafquatul Islam

Electronic Theses and Dissertations

Advancements in microscale actuating technologies has substantially expanded the possibilities of interacting with the surrounding environment. Microstructures that deflect in response to mechanical forces are one of the largest application areas of microelectromechanical systems (MEMS). MEMS devices, functioning as sensors, actuators, and support structures, find applications in inertial sensors, pressure sensors, chemical sensors, and robotics, among others. Driven by the critical role of catalytic membrane reactors, this dissertation aims to evaluate enzyme activity on polymeric membranes and explore how fabrication methods from the field of Electrical and Computer Engineering (ECE) can incorporate sensing and actuation into these porous surfaces. Toward …

Adaptive Personalized Drug Delivery Method For Warfarin And Anemia Management: Modeling And Control., Affan Affan

Electronic Theses and Dissertations

Personalized precision medicine aims to develop the appropriate treatments for suitable patients at the right time to obtain optimal results. Personalized medicine is challenging due to inter- and intra-patient variability, narrow therapeutic window, the effect of other medications, comorbidity (more than one disease at a time), nonlinear patient dynamics, and time-varying patient dose response characteristics which include bleeding (internal and external). This research aims to develop a framework for an adaptive personalized modeling and control method with minimum clinical patient specific dose response data for optimal drug dosing. The proposed methodology is applied to anemia and warfarin management. It is …

Design, Fabrication, And Integration Of Robotic Skin Sensors For Human Robot Interaction., Olalekan Olakitan Olowo

Electronic Theses and Dissertations

Enhancing physical human-robot interaction in modern robotics relies on refining the tactile perception of robot skin sensors. This research focuses on crucial aspects of the development process, including fabrication techniques, miniaturization, and integration for a more efficient collaborative human-robot interface. The fabrication process of robot skin sensors, designed to mimic human skin, is explored both within and outside cleanroom environments. An enhanced technique is presented to increase fabrication yield and create more miniaturized sensor designs with feature sizes in the tens of microns. These sensors function as piezoresistive arrays using organic polymers like PEDOT: PSS as the pressure-sensing medium. Various …

Impact Of Weather Factors On Airport Arrival Rates: Application Of Machine Learning In Air Transportation, Robert W. Maxson, Dothang Truong, Woojin Choi

Publications

Weather is responsible for approximately 70% of air transportation delays in the National Airspace System, and delays resulting from convective weather alone cost airlines and passengers millions of dollars each year due to delays that could be avoided. This research sought to establish relationships between environmental variables and airport efficiency estimates by data mining archived weather and airport performance data at ten geographically and climatologically different airports. Several meaningful relationships were discovered from six out of ten airports using various machine learning methods within an overarching data mining protocol, and the developed models were tested using historical data.

Optical And Electrical Interfaces For Biological Structures, Mehdi Bandali

Boise State University Theses and Dissertations

This dissertation presents novel solutions for recording optical and electrical data from biological structures. CHAPTER ONE discusses the 16×16 Time correlated SPAD image array I developed in a 180 nm HV CMOS process for single-molecule localization super-resolution microscopy (SRM). This image array has a maximum frame rate of 80 MHz and a fill factor of 17.4 %. To demonstrate SRM with this imaging array, we localized gold nanoparticle displacement at 40 nm. CHAPTER TWO discusses stimulation artifacts' time and frequency domain characteristics and potential strategies for canceling this interference on neural recording. CHAPTER THREE discusses an artifact-resilient neural recording front-end …

Hybrid Wall Outlet For Ac Or Dc Power Delivery, Garrett Knoller, Kerr Allan, Greg Perini

Electrical Engineering

The goal of this project is to develop hybrid DC and AC wall outlets for an efficient, flexible power interface. A DC plug standard is also proposed to allow DC devices to be safely powered by the outlet with the correct DC voltage for each device. The primary objective is to create a power outlet compatible with the proposed DC plug as well as NEMA 5-15 AC plugs, enabling the same outlet to power both types of load as needed. The outlet is intended for buildings and systems transitioning to an isolated DC grid to encourage DC development and adoption. …

Dc To Ac Inverter For A Microgrid-Inspired Power Distribution Architecture For Electric Vehicles, Bryan A. Carrillo Martinez, Eli Blacklock, Paul A. Samson, William S. Holt-Hillis

Electrical Engineering

This project builds upon the prototyping of a microgrid-inspired power distribution architecture for electric vehicles (EVs). The efficacy of this prototype aims to inform a full-scale power distribution system that charges an EV battery, supports the electric grid with important ancillary services, performs peer-to-peer EV charging, and works in conjunction with other AC and DC sources and loads. The scope of this report focuses specifically on the design, construction, and testing of the DC/AC inverter. Future development of this distribution architecture will incorporate synchronous generators, a battery management system, and an Arduino/Raspberry Pi-based communication system to fully simulate an electric …

Digital Filter Implementation On A Dsp Development Board, Tien Le, Helen Zhang

Electrical Engineering

This project to implement digital filters on a Digital Signal Processor (DSP) development board intends to demonstrate viability for future use in teaching digital signal processing lab courses. The digital filter types covered, including Finite Impulse Response (FIR) and Infinite Impulse Response (IIR) filters of various basic frequency responses, will mirror current DSP lab projects to fulfill course learning objectives for filter design and characterization. Design features will include speed optimization to enable real-time digital signal processing. This project will investigate the use of Code Composer Studio to compile C and assembly code to the DSP. Alternatives for currently available …

4-Band Personal Eq Device, Carson Kellerman

Electrical Engineering

The device is a 4-band EQ with 3.5mm audio input and output jacks. The device has 4 adjustable EQ bands. Each of the 4 bands are adjustable via knob potentiometers, and are able to boost or cut their respective center frequencies of 150Hz, 400Hz, 2500Hz, and 10kHz from -15dB to +15dB. The device is battery powered off of 1 9V battery and is able to function for 10 hours before needing to replace the batteries. The device has a Total Harmonic Distortion of less than 1% and a Signal to Noise Ratio greater than 60dB. Overall, this device allows music …

Design Of An Angle Measurement Device Using Ultrasonic Pairs, Shadi Khanpour Doustkar

Electrical Engineering

In this paper, a new concept for ultrasonic indoor positioning built upon instantaneous frequency of ultrasonic signals is presented. Ultrasonic sensors are inexpensive and manageable sensors; they are currently not used to good advantage with their potential for the electronics industry. The current ultrasonic sensors in the market only present a distance value to the nearest object for the user and due to this kind of feedback, it’s not attainable to find the relative position of the object from the sensor in a detection area; examples vary from workpieces and robots to even people. By using an algorithm and multiple …

The Private Pilot Check Ride: Applying The Spacing Effect Theory To Predict Time To Proficiency For The Practical Test, Michael Scott Harwin

Theses and Dissertations

This study examined the relationship between a set of targeted factors and the total flight time students needed to become ready to take the private pilot check ride. The study was grounded in Ebbinghaus’s (1885/1913/2013) forgetting curve theory and spacing effect, and Ausubel’s (1963) theory of meaningful learning. The research factors included (a) training time to proficiency, which represented the number of training days needed to become check-ride ready; (b) flight training program (Part 61 vs. Part 141); (c) organization offering the training program (2- or 4-year college/university vs. FBO); (d) scheduling policy (mandated vs. student-driven); and demographical variables, which …

Experiments And Simulations Of Liquid Mass Gauging And Slosh Dynamics In Microgravity, Jedediah Morse Storey

Theses and Dissertations

Advancements in liquid propellant management science and technologies are key to increasing safety, decreasing cost, and increasing payload mass of space missions. Propellant usually comprises a large portion of the total mass of launch vehicles and spacecraft, so liquid propellant sensing, as well as predicting and controlling the motion of it, are important. Electrical Capacitance Tomography (ECT) is an emerging sensing technology that is capable of measuring the distribution of liquid anywhere inside of a tank, potentially making it useful for measuring slosh and gauging mass. An ECT-instrumented tank was successfully tested in microgravity for the first time. Basics of …

How Students Learn: Examining The Differences In Learning Strategies Between Flight And Nonflight Students, Jennifer A. Torres

Theses and Dissertations

The purpose of this study was to determine if there were any differences in learning strategies between undergraduate flight and nonflight students attending a 4-year university that offered a Part 141 flight training program. Learning strategies were measured using Panadero et al.’s (2021) 30-item Deep Learning Strategies Questionnaire and its four subscales—Basic Learning Self-Regulation Strategies, Visual Elaboration and Summarizing Strategies, Deep Information Processing Strategies, and Social Learning Self-Regulation Strategies—all of which were the dependent variables. The primary independent variable was group membership, but the study also incorporated two covariates—self-efficacy and intrinsic value—which were measured using the respective subscales of Pintrich …

Safety Culture Surveys: Towards A Unified Method, Brandon Judy

Theses and Dissertations

This thesis examines the relationship between two aviation safety culture scales: the Airline Safety Culture Index (ASCI; Flight Safety Foundation, 2001) and the Organizational Safety Culture Questionnaire (OSCQ; Patankar, 2003). This study compared two safety culture instruments using a correlational methodology. The two scales were combined into a questionnaire distributed to hundreds of aviation students and professionals. The students were sampled using a stratified cluster sample method, and the professionals were sampled using a snowball method. There were 259 initial usable responses; after outliers were removed, the sample size was 244. A Pearson’s product-moment correlation found that the ASCI and …

Design Space Visualization And Exploration For Many Goal Problems Under Uncertainity, Niharika Balaji

Theses and Dissertations

ABSTRACT

Designing a complex engineered system is challenging due to many conflicting goals, uncertainties, and multiple interactions. Traditional optimization approaches often yield single-point solutions, which may not be suitable for early design stages due to their susceptibility to changes in conditions and uncertainties. To address this challenge, a satisficing approach is employed. This approach enables designers to effectively navigate the design space and identify satisficing solutions that balance conflicting goals in the face of uncertainties and changes in conditions. From a systems design perspective, we view design as an iterative process that involves making informed decisions based on available information …

Metasurface Beam-Steering Antenna At X-Band Frequencies With Cloaking Applications, Erik Jermaine Kosh

Theses and Dissertations

I intend to use metasurface materials to adjust antenna field properties while applying a cloaking application to the antenna. Cloaking applications have been used to shield the neighboring antenna waveforms so that they do not affect it’s antenna patterns and reduce the mutual coupling between the two antennas [15], [16]. In this application, I propose a metasurface beam-steering antenna at X-band frequencies using mantle-cloaking techniques to adjust and direct the beam-steering while ignoring other adjacent antenna patterns.

The first part of this application provides a method for cloaking antennas that are close to each other in distance (less than a …

Qasm-To-Hls: A Framework For Accelerating Quantum Circuit Emulation On High-Performance Reconfigurable Computers, Anshul Maurya

Theses and Dissertations

High-performance reconfigurable computers (HPRCs) make use of Field-Programmable Gate Arrays (FPGAs) for efficient emulation of quantum algorithms. Generally, algorithm-specific architectures are implemented on the FPGAs and there is very little flexibility. Moreover, mapping a quantum algorithm onto its equivalent FPGA emulation architecture is challenging. In this work, we present an automation framework for converting quantum circuits to their equivalent FPGA emulation architectures. The framework processes quantum circuits represented in Quantum Assembly Language (QASM) and derives high-level descriptions of the hardware emulation architectures for High-Level Synthesis (HLS) on HPRCs. The framework generates the code for a heterogeneous architecture consisting of a …

Band Motor Crankshaft For Hydrogen Combustion Engine, Lincoln Hofer, Jacqueline Mendoza Cortes, Austin Rhee, Roze Raymond

Mechanical Engineering

This report outlines the steps in which a group of four mechanical engineers at California Polytechnic State University California, San Luis Obispo, addressed an issue brought up by Professor Roger Benham from the Materials Department. The task included developing an automated and modular testing platform for a revolutionary concept crankshaft prototype – meant for a hydrogen combustion engine - developed and produced by the sponsor: Roger Benham. A testing platform is necessary to measure the performance of the shaft design created to eventually implement this subsystem into a complete hydrogen engine design. Values being tested include geometric validation, maximum static …

Interactive Water Vortex Exhibit, Simon Way, Emily Laing, Roqaya Naseri, Makenzie Kan

Mechanical Engineering

The San Luis Obispo Children’s Museum requested an interactive water vortex exhibit to both engage and entertain inquisitive guests, ages two to eight. The goal was to design and manufacture an exhibit that would educate its users on the fluid mechanics behind water vortices. They activate the mechanics by spinning a wheel, which is perceived as the catalyst to manipulate the flow of water to successfully create a whirlpool. Our team has created an interactive display that will enlighten young minds, providing the museum with an educational exhibit which shares a concept not currently taught by any other. Our project …

Exploring The Potential Of Tesla Valve For Filtering And Sorting Microscale Active Swimmers: A Computational Study, Ariel Rogers, Zhiyao He, Yong Wang

Physics Faculty Publications and Presentations

It is well-known that a Tesla valve allows fluids to flow unidirectionally without moving parts; however, how Tesla valves interact with active matters and the potential applications of Tesla valves in biology remain largely unexplored. Here, we present a computational study on the potential use of Tesla valves for filtering and sorting microscale active swimmers such as bacteria. We investigated the behavior of microscale swimmers passing through the Tesla valve at different linear and angular velocities using numerical simulations and quantified the diodicity of the Tesla valve for active swimmers. Our results demonstrate that the Tesla valve can effectively filter …

The Shape Modulation Of Laser-Induced Nanowelded Microstructures Using Two Colors, Ariel Rogers, Isabelle Niyonshuti, Jun Ou, Diksha Shrestha, Deborah Okyere, Jingyi Chen, Yong Wang

Physics Faculty Publications and Presentations

The light-based nanowelding of metallic nanoparticles is of particular interest because it provides convenient and controlled means for the conversion of nanoparticles into microstructures and the fabrication of nanodevices. In this study, we investigated the wavelength dependence of laser-induced nanowelded shapes of silver nanoparticles (AgNPs). We observed that the nanowelded microstructures illuminated with only a 405 nm laser were more branched than those formed via illumination using both the 405 nm and 532 nm lasers. We quantified this observation by two compactness descriptors and examined the dependence of the power of the 532 nm laser. More importantly, to understand the …

Synthesis Of Glucomannan-Xylan Composite Biofilms: Characterization And Applications For Food Packaging, Kholoud Al-Ajlouni

Dissertations

Scientists are most concerned about the need for green alternatives for efficient food packaging polymers to replace petroleum-based packaging products. The waste of corn cobs and the roots of the konjac plant contain hemicellulose, xylan and glucomannan respectively, and can be used to produce biofilms for food packaging.

The aim of these studies is to formulate biofilms from glucomannan-xylan blends that compete with petroleum-based plastic wrap. The biofilms must be strong, smooth, transparent, have a water vapor barrier, have the required mechanical properties and be cheap. Biofilms from glucomannan were stiff, lacked mechanical properties, and absorbed moisture. Therefore, it reacts …

Experimental And Numerical Study Of Low-Velocity Impact Damage In Sandwich Panel With Uhmwpe Composite Facings, Bin Yang, Qi Zhou, Juhyeong Lee, Yan Li, Kunkun Fu, Dongmin Yang

Mechanical and Aerospace Engineering Faculty Publications

This paper is concerned with the low-velocity impact (LVI) response behaviour of sandwich composite panels (SCPs) with ultra-high molecular weight polyethylene (UHMWPE) composite facings and Polyvinyl Chloride (PVC)/Polyethylene Terephthalate (PET) foam cores. A series of LVI tests with SCPs subjected to 50 J, 80 J and 110 J were conducted to examine their impact characteristics and damage mechanisms. LVI-induced internal damage in the SCPs were characterised by compute micro-tomography (μCT) analysis. The effects of UHMWPE areal density and foam type on the LVI responses and associated failure modes of the panels were also examined. The experimental results showed that the …

Assessing Chondrocyte Viability Of Articular Cartilage Using Label-Free Imaging Methods, Hongming Fan

All Dissertations

ABSTRACT

Articular cartilage covers the ends of bones, providing a protective layer that can endure forces during movement. Chondrocytes, the only cell type found in articular cartilage, produce collagen fibers and proteoglycans that maintain the extracellular matrix (ECM). Cartilage damage impairs chondrocytes and their ability to maintain tissue stability. There are various factors that can cause cell death, which can be broadly classified into two categories: programmed cell death (apoptosis) and non-programmed cell death (necrosis). The consequences of cell death can have significant impacts on the extracellular matrix (ECM). The ECM is a complex network of proteins and carbohydrates that …

An In Vitro Platform To Characterize Myocardial Wound Remodeling, Jonathan Heywood

All Dissertations

Heart Failure, sometimes called Congestive Heart Failure, is a collection of pathological disruptions in which the heart is unable to pump blood properly. It affects over 6 million people in the United States, with the cost-per-patient at approximately $30,000 and the total cost estimated to be $160 billion by 2030. There is no single cause of heart failure, as it can manifest as a varying array of diseases, disorders, and syndromes. However, many of these underlying diseases result specifically from dysregulation of mechanically active cells called cardiac fibroblasts, which play a critical role in the remodeling of the extracellular matrix …

Model-Free Methods To Analyze Pmu Data In Real-Time For Situational Awareness And Stability Monitoring, Sean Kantra

All Dissertations

This dissertation presents and evaluates model-free methodologies to process Phasor Measurement Unit (PMU) data. Model-based PMU applications require knowledge of the system topology, most frequently the system admittance matrix. For large systems, the admittance matrix, or other system parameters, can be time-consuming to integrate into supporting PMU applications. These data sources are often sensitive and can require permissions to access, delaying the implementation of model-based approaches. This dissertation focuses on evaluating individual model-free applications to efficiently perform functions of interest to system operators for real-time situational awareness. Real-time situational awareness is evaluated with respect to central digitization where the PMU …

Physics-Based Machine Learning Methods For Control And Sensing In Fish-Like Robots, Colin Rodwell

All Dissertations

Underwater robots are important for the construction and maintenance of underwater infrastructure, underwater resource extraction, and defense. However, they currently fall far behind biological swimmers such as fish in agility, efficiency, and sensing capabilities. As a result, mimicking the capabilities of biological swimmers has become an area of significant research interest. In this work, we focus specifically on improving the control and sensing capabilities of fish-like robots.

Our control work focuses on using the Chaplygin sleigh, a two-dimensional nonholonomic system which has been used to model fish-like swimming, as part of a curriculum to train a reinforcement learning agent to …

Structural Characterization Of Cardiomyocyte Microenvironment In Murine Myocardium By Multimodal Stimulated Emission Depletion Microscopy, Zhao Zhang

All Dissertations

Cardiomyopathy, a disease of the heart muscle, is characterized by structural and functional abnormalities of the myocardium, in the absence of coronary artery disease, hypertension, valvular disease or congenital heart disease. In 2020, there were approximately 6.11 million prevalent cases of cardiomyopathy and myocarditis, and 0.37 million related deaths worldwide. Many affected individuals are asymptomatic, and chronically treated patients are at risk of heart failure. Within the myocardium, cardiomyocytes reside in a complex and dynamic extracellular matrix (ECM), consisting of basement membrane and interstitial matrix. The interactions between cardiomyocytes and myocardial ECM play a critical role in maintaining cardiac geometry …