Engineering Commons^™

Alteration Of Peripheral Cytokines In Alzheimer’S Disease, Zhengshi Yang

UNLV Theses, Dissertations, Professional Papers, and Capstones

Alzheimer’s disease (AD) is a progressive neurodegenerative disease with the clinical symptoms of gradual cognitive decline and memory loss. Biologically, abnormal accumulation of Aβ (Aβ) plaque and tau tangles in the brain are the core pathological hallmarks in AD. Although inflammatory response is not specific to AD, emerging evidence suggests that the disrupted innate immune system within the central nervous system, particularly microglial activation, might act as the bridge linking Aβ aggregation to pathological phosphorylation and aggregation of tau. The inflammatory response was suggested to initially have a neuroprotective role of attempting to clear Aβ plaques, and then become neurotoxic …

Design And Optimization Of Matrix Core Transformer For High Power Bidirectional Isolated Dc/Dc Converter, Zhe Zhao

Graduate Theses and Dissertations

Thanks to the advancement of semiconductor technology, the silicon carbide (SiC) devices with high voltage and power capability are developed and widely used in several industry applications, e.g., gird-connected photovoltaic (PV) system, data center power supply, and electrical vehicle (EV) charging station. After the concept of solid-state transformer (SST) was proposed as an important solution to the medium voltage (MV) power conversion systems, this bidirectional isolated DC/DC converter has attracted much attention in academia and industry. One of the main advantages of SST is to improve both the power density and efficiency of the power conversion system by replacing the …

Performance Evaluation Of Surface Treatment Waste Glass As Aggregate In Asphalt Mixture, Miao Yu, Dongzhao Jin, Yu Liu, Zhanping You, Yalong Li

Michigan Tech Publications

Surface modification is a crucial strategy for enhancing the pavement performance of waste glass hot mix asphalt (HMA) mixtures. This study conducts a comparative analysis of various surface modification techniques to pinpoint the key factors that influence the interfacial interaction between waste glass and asphalt. To assess the performance of asphalt mixtures containing surface-treated waste glass, the study employed methods such as Energy Dispersive X-ray Spectroscopy (EDS), boiling water tests, and contact angle measurements, which helped to quantify surface morphology and the effectiveness of different treatments. The evaluation also included assessments of water stability, dynamic stability, small beam bending, and …

Fabrication And Charcaterization Of Pullulan-Collagen Nanofibers Via Forcespinning, Valeria Leon Leal

Theses and Dissertations

Extensive research on collagen has spurred advancements in tissue engineering and biomaterial development, given collagen´s pivotal role in regulating various tissue structures across diverse organisms. This study delves into fabricating nanocomposites utilizing collagen, along with silver nanoparticles, chondroitin sulfate and pullulan, for potential applications in antibacterial medical devices, and cell regeneration. Collagen, abundant in the extracellular matrix, provides essential structural support, while silver nanoparticles and chondroitin confer antimicrobial properties, crucial for combating infections. Pullulan, a polysaccharide polymer, serves as a biocompatible carrier for silver nanoparticles whilst being the starting nanofiber forming material. Utilizing Forcespinning® technology, composite nanofibers were successfully synthesized. …

Recovery Resiliency Of Interdependent Power Systems Infrastructure Subject To Extreme Events, Partha P. Sarker

Graduate Theses and Dissertations (2019 - present)

When Hurricane Maria struck the island of Puerto Rico on September 20, 2017, it devastated the island’s aging power systems infrastructure and inflicted an island-wide power outage that left Puerto Rico in total darkness for an entire week before the system slowly started to recover. This unprecedented failure of the critical power systems infrastructure exacerbated the failure of other critical infrastructures or lifeline systems of the island. This research explores and quantifies the relationships or interdependencies that exist between the power systems and other critical infrastructure systems by investigating the post-hurricane recovery data of these lifeline systems. Subsequently, the research …

Three-Dimensional Environmentally Sustainable Neuromorphic Computing System Based On Natural Organic Memristor, Mohammed Rafeeq Khan

Graduate Theses and Dissertations (2019 - present)

A three-dimensional neuromorphic (3D) computing architecture based on environmentally sustainable natural organic honey memristors is proposed in this thesis. A set of comprehensive and experimental results indicate that the proposed systems exhibit remarkable inference accuracy, consistently surpassing the 90% threshold, even with different challenges such as device variations and nonlinearity. This study also considers four different conductance drift situations, the effects of analog-to-digital converter (ADC) quantization, and multiple algorithms, such as VGG8 and DenseNet-40. The deliverable of this thesis will test the stability of the proposed systems and explore their potential applications and scalability in real-world situations.

White Hall Green Roof Proposal, Hope Dwyer

Biological and Agricultural Engineering Undergraduate Honors Theses

This project will propose designs for a GR system while determining the potential cost, the feasibility of the system implementation, as well as potential psychological and educational benefits of a GR system. These factors will be examined and evaluated with regard to two different proposed GR designs: extensive and intensive.

Quantum Visual Feature Encoding Revisited, Xuan-Bac Nguyen, Hoang-Quan Nguyen, Hugh Churchill, Samee U. Khan, Khoa Luu

Computer Science and Computer Engineering Faculty Publications and Presentations

Although quantum machine learning has been introduced for a while, its applications in computer vision are still limited. This paper, therefore, revisits the quantum visual encoding strategies, the initial step in quantum machine learning. Investigating the root cause, we uncover that the existing quantum encoding design fails to ensure information preservation of the visual features after the encoding process, thus complicating the learning process of the quantum machine learning models. In particular, the problem, termed the “Quantum Information Gap” (QIG), leads to an information gap between classical and corresponding quantum features. We provide theoretical proof and practical examples with visualization …

Synthesis Of Binary-Input Multi-Valued Output Optical Cascades For Reversible And Quantum Technologies, Ishani Agarwal, Miroslav Saraivanov, Marek Perkowski

Electrical and Computer Engineering Faculty Publications and Presentations

This paper extends the decomposition from the group theory based methods of Sasao and Saraivanov to design binary input multivalued output quantum cascades realized with optical NOT, SWAP, and Fredkin Gates. We present this method for 3, 5, and 7 valued outputs, but in general it can be used for odd prime valued outputs. The method can be extended to realize hybrid functions with different valued outputs. A class of local transformations is presented that can simplify the final cascade circuits. Using these simplifying transformations, we present an upper bound on the maximum number of gates in an arbitrary -variable …

The Clot Thickens: Investigation Of The Mechanism Behind Hypercoagulation In Covid-19 Patients, Toni Warnick

All Dissertations

Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with cardiovascular complications, which correlate with illness severity and increased mortality. It was initially thought that this hypercoagulable state was induced by endothelial dysfunction or cytokine storm because of SARS-CoV-2 infection. Although platelets have been reported to express the SARS-CoV-2 primary target receptor, angiotensin-converting enzyme 2 (ACE2), this remains controversial due to conflicting findings that suggest minimal to no ACE2 expression on platelets. This ambiguity has led to exploring alternative entry pathways, notably via the virus’s RGD (arginine-glycine-aspartic acid) sequence within its spike protein receptor-binding …

Magnetic Nano And Micro Rods As Tools For Characterizing Materials Mechanical Properties: Fundamentals And Applications, Artis Brasovs

All Dissertations

The focus of this dissertation is insect blood (Hemolymph). Hemolymph is analyzed by taking a materials science approach. Rheological characterization of hemolymph has been performed for the first time. Owing to a minute amount of available material, a new protocol was established where Magnetic Rotational Spectroscopy (MRS) with ferromagnetic nanorods was employed. The challenge was examining the microliter droplets' viscosity in less than a few minutes. This challenge was successfully resolved.

Blood is critical for the insect's survival: after wounding, the insect has to seal the wound quickly, in a few minutes. As the mechanism of fast clotting has never …

Isolation And Upgrading Of Lignin From Agricultural Sources Using Phase Equilibria, Bronson Lynn

All Dissertations

In the emerging bioeconomy, agricultural residues from our nationwide crop harvests are positioned to be a cornerstone of renewable and sustainable fuels, chemicals, and materials. However, to be economically viable, the basic constituents of this plant matter must be separated and funneled to the appropriate application to maximize value and overall usability.

This work focuses on the component that has, to this point, been largely left behind: lignin. Although it is the most abundant aromatic biopolymer on the planet, making up 15-40% of grasses, hardwoods, and softwoods, the processing involved to isolate usable lignins is too complex and expensive to …

A Multiple Mixed-Method Analysis On Empathy In First Year Engineering Education, Libby Flanagan

All Dissertations

This multiple mixed method analysis focuses on exploring how teaching empathy to first year engineering students interacts with their engineering identity and their personal definition of the role of an engineer. The participants received a four-lesson series on empathy and engineering in the Fall of 2023. They completed a pre- and post-survey as well as wrote five written reflections over the course of this semester. Analysis of the survey results found that composite empathy and engineering identity scores increased significantly over the course of this semester and that the increase in female composite engineering identity scores was significantly larger than …

Laser Processing Of Multi-Phase Ceramics, Siddhartha Sarkar

All Dissertations

This research explores laser-based processing for multi-phase ceramics, offering a faster, more energy-efficient alternative to conventional ceramic fabrication. Four material systems are explored: silica-titania, alumina-iron, polymer-derived ceramic SiC-gadolinium zirconate, and polymer-derived ceramic SiC-yttrium silicate.

The silica-titania study presents a novel direct CO₂ laser writing approach to fabricating pure silica and silica-titania glasses with exceptional dimensional control and optical transparency, enabling fine spatial resolution, instantaneous consolidation, and eliminating post-heat treatment. Notably, the TiO₂ solubility in the silica network achieved is higher than previously reported, with structures remaining crack-free and transparent up to a specific TiO₂ percentage.

The alumina-iron …

Computational Representation, Analysis And Verification Of Requirements In Engineering Design And Systems Engineering, Chandan Kumar Sahu

All Dissertations

Systems are developed to satisfy a set of requirements derived from stakeholders’ needs, defining the problem space for which the system is created as a feasible solution. The system design process begins with eliciting these requirements and concludes with validating whether the created system meets them. Requirements engineering (RE) encompasses elicitation, representation, analysis, documentation, verification, and validation. However, challenges in RE, such as imprecision in natural language (NL), proprietary restrictions, and a lack of standardized quality metrics, hinder the creation of well-formed and comprehensive requirements. These challenges complicate formalization and analysis of requirements.

This dissertation addresses these challenges by proposing …

Nanostructured Silicon Meta-Waveguides And Surfaces For Enhanced Light-Matter Interaction, Saddam Gafsi

All Dissertations

In this study, we tackle the challenge of light-matter interaction engineering and local field enhancement using various silicon photonic platforms based on three different approaches. (i) The first approach is based on boundary condition engineering where we present and show through simulation and experimental results, a silicon nanodisk “diabolo” configuration able to support significant local field enhancement levels in the range ~102 to 104 in the high index medium through proper structural modifications at the nanoscale. We show that the presented optical behavior is consistent with the anapole modes characterized by the observed near-field enhancement and coinciding with far-field suppression. …

Optimization Of Polymeric Micelles As A Delivery System For Crispr/Cas9 Ribonucleoprotein, Lucian Williams

All Dissertations

Clustered regularly interspaced short palindromic repeats (CRISPR) is an adaptive immune system in bacteria that has been harnessed to perform precise genetic modifications in mammalian cells. Among CRISPR-associated (Cas) proteins, Cas9 has emerged as a transformative tool in gene editing due to its simplicity, high specificity, and versatility compared to the other Cas proteins and gene-editing technologies. Despite its potential to cure genetic disorders, the clinical application of Cas9 has been hindered by challenges such as immunogenicity, off-target effects, and low delivery efficiency. To address these issues, this dissertation explores using polymeric nanoparticle systems to encapsulate and protect Cas9 and …

Protocol Transformations Across Osi Network Stack Layers For Attack, Evasion, And Defense, Nathan Tusing

All Dissertations

Network endpoints frequently contend with errors and deviations within protocols. Many factors account for these deviations including noise, tampering, and algorithm implementations. Intermediate nodes are expected to modify instantiated protocols and not guarantee correctness. This ability to modify traffic enables all sides of network security to alter security and performance properties of protocols, and we define this intermediary modification of an instantiated protocol as a transformation. Protocol transformations traverse layers of the OSI reference model and changes a protocol's time series byte sequence. Within this thesis, we show that this framework applies to multiple domains and protocols. Common examples of …

Enhancing Protonic Ceramic Fuel Cells By Advanced Laser Processing For Superior Performance, Tianyi Zhou

All Dissertations

As global temperatures rise, the demand for clean energy solutions intensifies. Protonic ceramic fuel cells (PCFCs) offer advantages like higher conductivity at moderate temperatures (300–700 °C), fuel flexibility, stability, and lower costs. However, traditional PCFC manufacturing faces challenges with interface defects, structural imperfections, and scalability, especially in producing large-area cells and stacks.

This work addresses these issues using advanced laser processing techniques. Laser ablation and direct laser rapid additive manufacturing (DL-RAM) enable precise control of PCFC microstructures, removing surface defects and increasing bonding strength for higher efficiency. Digital layer deposition allows for large-area PCFC single cells and stack production with …

Supporting Holistic, Informed, Decision-Making Through The Complementarity Of Life Cycle Assessment And Radiological Protection, Bryanna Wattier-Weisensee

All Dissertations

Decision making is challenging and it is necessary to consider all relevant data to make an informed decision. The work herein provides a pathway wherein the fields of radiological protection and life cycle assessment (LCA) can be utilized synergistically to benefit the decision-making using the other (and vice versa). Specifically, LCA parallels decision-aiding techniques used in the optimization of radiological protection and LCA includes an ionizing radiation potential (IRP) impact category wherein the impacts associated with an emission of radioactive material is quantified to determine the human health impact. Thus this body of work focuses on (1) expanding the platform …

Exploring The Compositional Limits Of Y2o3-Al2o3-Sio2 Optical Fibers, Miranda Stone

All Dissertations

Of the widely varying compositions fabricated into optical fibers using the molten core method (MCM), the most studied by far as been those in the Y₂O₃-Al₂O₃-SiO₂ (YAS) system. Such fibers have been shown to be of interest for fiber amplifiers and lasers since they exhibit a good balance between reasonable loss, intrinsically low optical nonlinearities, and efficient gain. The majority of the fibers studied globally to-date have primarily focused on YAG-derived fibers, i.e., YAG (Y₃Al₅O₁₂) single crystals drawn in a pure SiO₂ cladding glass) …

An Efficient Computational Frameworks For Design And Analysis Of Metamaterials, Raj Pradip Khawale

All Dissertations

Advancement in additive manufacturing helps in building artificial lattice structures with unique properties that are not available in naturally occurring materials or in continuum structures. Specifically, beam-based lattices are well known for producing lightweight structures with very high strength, auxetic behavior, and energy absorption capabilities. In recent years, numerous research studies have been conducted on generating algorithms and frameworks to obtain unusual properties based on the variation in the cell geometry and material properties. However, the exploration of the full design space is hampered in practice primarily due to restrictions on cell tiling variation. Additionally, the lattices are very intricate, …

Short-Circuit Modeling And Instantaneous Overvoltage Protection Of Renewable Farms, Shah Mohazzem Hossain

All Dissertations

The existing utility grid is experiencing a paradigm shift in electricity generation due to a significant penetration of renewable energy sources. This shift is primarily driven by the large-scale integration of solar and wind energy farms, particularly in the transmission network, where these farms are typically accompanied by battery energy storage in a hybrid configuration to overcome source intermittency and improve reliability. Such renewable farms comprise numerous inverters, pad-mounted transformers, collector feeders, and dc-side components depending on the generation-source type. Additionally, inverters within these farms exhibit distinct operating modes, such as `grid-following'(GFL) and `grid-forming'(GFM), as well as fault control modes, …

Low Carbon, High Cooling Potential Alcohol Fuels In A High Compression Ratio Spark Ignition Engine, John Gandolfo

All Dissertations

Even though most of the effort towards implementing low-carbon alternative fuels has been directed towards heavy-duty vehicles that are difficult to electrify, the high-autoignition resistance of these fuels make them challenging to combust in compression ignition engines. However, several fuel candidates, such as ethanol and methanol, are ideal fuels for spark ignition engines. With the demand for electric vehicles slowing down and increasing recognition of the merits of hybrid powertrains, there is a need to maximize the performance of these fuels for spark ignition engines, which are likely to remain the combustion strategy of choice for hybrids due to their …

Multifunctional Peptides To Improve Nucleic Acid Delivery For Ovarian Cancer Treatment, Kharimat Lora Alatise

All Dissertations

RNA interference (RNAi) therapies, such as small interfering RNA (siRNA), offer a high-precision approach to reducing the expression of disease-promoting genes with minimal off-target effects. For aggressive diseases like ovarian cancer, RNAi therapy can serve as a robust treatment modality if delivered successfully. Over 70% of ovarian cancer patients are diagnosed in stages three and four, where the disease becomes more difficult to treat. High relapse rates and drug resistance in these stages demonstrate the need for novel strategies to sensitize tumors to chemotherapy, making siRNA a promising avenue for targeting resistance-associated oncogenes.

However, the delivery of siRNA remains a …

Investigating The Role Of Cd44 In Her2+ Breast Cancer Cells During Cancer Cell Redirection, Holly Caroline Jordan Campbell

All Dissertations

Despite a rise in survival rates of breast cancer patients due to advances in modern medicine, breast cancer is the most common type of cancer in women and is the second leading cause of cancer death in the United States. Early detection and a more personalized treatment of breast cancer has slowly improved patient outcomes. Nevertheless, there are impediments to better patient outcomes due to the complexity of the disease physiology. Therefore, there is a demand for a comprehensive understanding of cancer development as well as a need to understand tumor progression for enhanced therapies for patients.

Previous in vivo …

An Automated Design Flow From Synchronous Rtl To Optimized Layout Using Commercial Eda Tools For Multi-Threshold Null Convention Logic Circuits, Cole Harrington Sherrill

Graduate Theses and Dissertations

This work presents the first automated design flow from synchronous RTL to highly optimized layout for Multi-Threshold NULL Convention Logic (MTNCL) circuits. The developed synthesis flow overcomes many of the drawbacks of existing attempts and leverages the advanced optimization features provided by modern synthesis tools. The remaining timing race conditions native to the MTNCL architecture have been identified and thoroughly explored. Two sets of novel timing constraints were devised: the first responds to these race conditions, yielding highly reliable MTNCL circuits; the second directly targets the critical paths within MTNCL circuits, allowing the designer to optimize the target circuit for …

Interaction-Sensitive Tree-Based Statistical Models, Xiaotong Sun

Graduate Theses and Dissertations

This dissertation introduces a tree-based framework to improve the interpretability and modeling of interaction effects among variables, essential in fields like biostatistics, healthcare, science and engineering. Traditional regression methods often fail to clearly capture complex interactions, while tree-based approaches, despite their interpretability, face performance limitations and overfitting concerns. Our proposed interaction-sensitive tree-based method, designed for seamless integration, combines various statistical techniques tailored to different data types, leveraging ensemble learning methods to enhance accuracy and mitigate overfitting. We present methods for regression, survival analysis, and classification, validated with case studies and benchmarked against traditional models using metrics like BIC and R-squared. …

Identifying Payable Cluster Distributions For Improved Reservoir Characterization: A Robust Unsupervised Ml Strategy For Rock Typing Of Depositional Facies In Heterogeneous Rocks, Umar Ashraf, Aqsa Anees, Hucai Zhang, Muhammad Ali, Hung Vo Thanh, Yujie Yuan

Research outputs 2022 to 2026

The oil and gas industry relies on accurately predicting profitable clusters in subsurface formations for geophysical reservoir analysis. It is challenging to predict payable clusters in complicated geological settings like the Lower Indus Basin, Pakistan. In complex, high-dimensional heterogeneous geological settings, traditional statistical methods seldom provide correct results. Therefore, this paper introduces a robust unsupervised AI strategy designed to identify and classify profitable zones using self-organizing maps (SOM) and K-means clustering techniques. Results of SOM and K-means clustering provided the reservoir potentials of six depositional facies types (MBSD, DCSD, MBSMD, SSiCL, SMDFM, MBSh) based on cluster distributions. The depositional facies …

Anti-Solvent Materials Enhanced Structural And Optical Properties On Ambiently Fabricated Perovskite Thin Films, Mohammad Nur-E-Alam, Mohammad Aminul Islam, Yap Boon Kar, Tiong Sieh Kiong, Halina Misran, Mayeen Uddin Khandaker, Yasser Fouad, Manzoore Elahi M. Soudagar, Erdem Cuce

Research outputs 2022 to 2026

Perovskite solar cells (PSCs) hold potential for low-cost, high-efficiency solar energy, but their sensitivity to moisture limits practical application. Current fabrication requires controlled environments, limiting mass production. Researchers aim to develop stable PSCs with longer lifetimes under ambient conditions. In this research work, we investigated the stability of perovskite films and solar cells fabricated and annealed in natural air using four different anti-solvents: toluene, ethyl acetate, diethyl ether, and chlorobenzene. Films (about 300 nm thick) were deposited via single-step spin-coating and subjected to ambient air-atmosphere for up to 30 days. We monitored changes in crystallinity, electrical properties, and optics over …