Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 13921 - 13950 of 196018

Full-Text Articles in Engineering

Fail-Safe Logic Design Strategies Within Modern Fpga Architectures, Priya A. Bhakta Dec 2024

Fail-Safe Logic Design Strategies Within Modern Fpga Architectures, Priya A. Bhakta

Electrical and Computer Engineering ETDs

Field Programmable Gate Arrays (FPGAs) are vulnerable to radiation-induced single event upsets (SEUs) and fault injection attacks, requiring the use of redundancy techniques such as fail-safe computing. Fail-safe computing refers to computing systems that revert to a non-operational safe state when a fault occurs. This work investigates circuit-level techniques and implements fail-safe computing processes as mitigation for SEUs and fault injection attacks on FPGAs. The analysis reveals vulnerabilities that exist in FPGAs over those in application-specific integrated circuits (ASIC); thus, requiring a more elaborate network of redundant circuits and checking logic. The reconfiguration capability of FPGAs adds complexity to fail-safe …


Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu Dec 2024

Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The discrete element method (DEM) is a widely used numerical approach for simulating and analyzing the behavior of granular materials in various applications. This research focuses on the iron ore beneficiation process, addressing the clumping issue in cohesive iron ores from existing crushing processes through a novel double-layered disperser design. The significance of this study lies in its potential to enhance the efficiency of the existing crushing phase and improve the linkage to subsequent purification stages that target smaller-sized iron ore pellets, thereby enhancing the overall efficiency of the ore beneficiation process and achieving significant energy savings. This research adopts …


An Intelligent System Using Deep Learning For Healthcare Monitoring In Light Of The Covid-19 And Future Pandemics Based On Iot, Sara Salman Qasim, Rajaa J. Khanjar, Jamal Nasir Hasoon, Baesher Abdullateff Abad, Ali Hussein Fadil, Shajan.M. Alsowaidi Dec 2024

An Intelligent System Using Deep Learning For Healthcare Monitoring In Light Of The Covid-19 And Future Pandemics Based On Iot, Sara Salman Qasim, Rajaa J. Khanjar, Jamal Nasir Hasoon, Baesher Abdullateff Abad, Ali Hussein Fadil, Shajan.M. Alsowaidi

Al-Esraa University College Journal for Engineering Sciences

Recently, the Internet of Things has become a compelling research field as a new topic of research in various disciplines, particularly in the field of healthcare, because the Internet of Things is rebuilding modern healthcare systems by integrating technology, economics, and social perspectives. The development of healthcare systems from traditional to more personalized systems in which patients can be easily diagnosed, monitored and treated and many people can be helped. People are treated and cared for remotely and this is what some people need in the crisis the world has been through like COVID-19. This epidemic is caused by the …


Speech Coding Based On A Hybrid Approach: Dct, Huffman And Run-Length Coding, Sundos Abdulameer Alazawi, Esraa Jaffar Baker, Shahbaa Mohammed Abdulmaged Dec 2024

Speech Coding Based On A Hybrid Approach: Dct, Huffman And Run-Length Coding, Sundos Abdulameer Alazawi, Esraa Jaffar Baker, Shahbaa Mohammed Abdulmaged

Al-Esraa University College Journal for Engineering Sciences

The exponential expansion of data in the digital world necessitates the development of effective methods for data transmission and storage. Data compression (DC) strategies are suggested to reduce the quantity of data stored or conveyed due to constrained resources. As a result of DC ideas' ability to efficiently use existing storage space and transmission capacity, different methods have been developed in various areas. Speech coding is a lossy method of coding; therefore, the output signal differs slightly from the input signal. Speech coding is useful for message encryption, communication over long distances and speech quality. In the fields of digital …


Measurement Of The Mechanical Properties Of Blood Vessels Using A Vascular Simulation Rig, Jack Lockyer Dec 2024

Measurement Of The Mechanical Properties Of Blood Vessels Using A Vascular Simulation Rig, Jack Lockyer

The Plymouth Student Scientist

Understanding the mechanical properties of blood vessels is crucial for reconstructive surgeons who connect donor tissue flaps to recipient sites. This paper describes the development of a vascular simulation test rig that delivers pulsatile flow to a blood vessel sample while continuously monitoring system pressure and sample diameter. These measurements allow for the calculation of the viscous coefficient, an important mechanical property for comparing blood vessels. A pilot test using the rig demonstrates its ability to measure pressure and diameter and highlights necessary improvements to enhance data quality. The pilot test shows that the current rig can measure 5 mm …


Investigation Of The Use Of Nanotechnology In Food Packaging, Ollie-May Woodland Dec 2024

Investigation Of The Use Of Nanotechnology In Food Packaging, Ollie-May Woodland

The Plymouth Student Scientist

This review discusses topics related to the use and development of nanotechnology and nanomaterials in food packaging applications. The accelerated use of these technologies brings about relevant safety, environmental, ethical and legislative/ regulatory concerns and as such the aim of this work is to assess the viability of the use of current commercialised nano-enabled packaging and to evaluate the potential future trends in the progression of these technologies against public opinion and potential risk(s). The data for this report was collected through comprehensive research of nanotechnology and its applications, specifically the packaging industry in the food sector. An online survey …


Real-Time Control (Rtc)-Based Urban Flood Risk Assessment Framework For Arid And Semi-Arid Regions, Sulaiman Altami Dec 2024

Real-Time Control (Rtc)-Based Urban Flood Risk Assessment Framework For Arid And Semi-Arid Regions, Sulaiman Altami

Dissertations - ALL

Global climate change has recently increased Flood Risk (FR) disasters in arid and semi-arid regions, particularly in Gulf countries, such as the Kingdom of Saudi Arabia (KSA). Arid regions generally face low rain on average during a year, but flash floods occur during rainfall of longer return periods due to urbanization and climate change. Flood Risk Assessment (FRA) outcomes enable municipalities (planners and decision-makers) in arid urban areas to develop flood management strategies and mitigate the issues of drainage systems, which may otherwise affect the quality of life. FRA is an effective tool for not only identifying high-risk areas but …


The Evolution Of The University Of Al-Anbar Urban Planning Based On The Mental Picture's Diversity And The Contemporary Planning Spaces Filling, Ali Abdulsamea Hameed Dec 2024

The Evolution Of The University Of Al-Anbar Urban Planning Based On The Mental Picture's Diversity And The Contemporary Planning Spaces Filling, Ali Abdulsamea Hameed

Al-Esraa University College Journal for Engineering Sciences

This research concentrated on the role of environmental graphic design (EGD) and the place-making idea in the interior environment of Al-Anbar University. To develop an identity being visual for the University of Al-Anbar internal environment (IE) is this goal of project. The search sought to create and enhance the shape of the internal University of Al-Anbar vacuum by reviving the idea of place building. In order to build and filling the internal emptiness of the campus, the identity being visual must also be strengthened. The descriptive analytical approach was chosen since it was best suited to achieve the goal of …


Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu Dec 2024

Discrete Element Method For Mining Industrial Applications: Solving The Clumping Problem Caused By Bulk Cohesive Particles In An Iron Ore Beneficiation Process, Shuang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The discrete element method (DEM) is a widely used numerical approach for simulating and analyzing the behavior of granular materials in various applications. This research focuses on the iron ore beneficiation process, addressing the clumping issue in cohesive iron ores from existing crushing processes through a novel double-layered disperser design. The significance of this study lies in its potential to enhance the efficiency of the existing crushing phase and improve the linkage to subsequent purification stages that target smaller-sized iron ore pellets, thereby enhancing the overall efficiency of the ore beneficiation process and achieving significant energy savings. This research adopts …


Modeling And Algorithms To Simplify Complex Multi-Clock/Edge Timing Constraints In High Performance Synchronous Digital Circuits, Nagbhushan Veerapaneni Dec 2024

Modeling And Algorithms To Simplify Complex Multi-Clock/Edge Timing Constraints In High Performance Synchronous Digital Circuits, Nagbhushan Veerapaneni

Dissertations - ALL

Complex timing constraints that refer to multiple clocks and/or edges are often used in the design of modern high-performance processors. Such constraints complicate downstream algorithms such as logic synthesis and lead to inefficiencies. The complexity of the overall CAD system can be reduced considerably if we can optimally transform the timing constraints so that they refer only to a single clock and edge. In this dissertation, we show how to model these multi clock/edge timing constraints and describe algorithms to reduce the number of reference clocks/edges. We first introduce the concept of timing specification transformation and define optimality. We formulate …


Studies On The Synthesis, Reactivity, And Stability Of Au Nanoparticles In Ts-1 Zeolites For Propylene Epoxidation Within H2/O2 Mixtures, Weixin Li Dec 2024

Studies On The Synthesis, Reactivity, And Stability Of Au Nanoparticles In Ts-1 Zeolites For Propylene Epoxidation Within H2/O2 Mixtures, Weixin Li

Dissertations - ALL

The increasing global demand for energy and materials has highlighted the importance of efficient production of chemical intermediates like propylene oxide (PO), a key compound in manufacturing polyurethanes, propylene glycol, and other industrial products. Traditional methods, such as the chlorohydrin process and organic peroxide methods, pose environmental and economic challenges due to hazardous by-products and complex processes. The need for greener alternatives led to the exploration of gold (Au) catalysts for the direct catalytic epoxidation of propylene using hydrogen (H2) and oxygen (O2). This research focused on understanding the propylene epoxidation process over Au catalysts, specifically Au nanoparticles (AuNPs) supported …


Wood-Plastic Composites Integration For Triboelectric Nanogenerator Electricity Generation, Hanbyeol Park, Razamala Yashna F. Dimaporo, Sophia Maureen A. Emperado, Anton Jefferson L. Pangilinan, Juan Carlo T. Gumangan Dec 2024

Wood-Plastic Composites Integration For Triboelectric Nanogenerator Electricity Generation, Hanbyeol Park, Razamala Yashna F. Dimaporo, Sophia Maureen A. Emperado, Anton Jefferson L. Pangilinan, Juan Carlo T. Gumangan

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Access to electricity in underdeveloped communities is particularly crucial in improving the living standards of people and alleviating poverty by promoting sustainable development. This study deals with the exploration of incorporating wood-plastic composite (WPC) – specifically wood pulp (W) and high-density polyethylene (H) – into triboelectric nanogenerator (TENG) flooring system to convert mechanical energy to electrical energy, promoting sustainable energy, reducing greenhouse gas emissions, improving the quality of life, and serving as feasible flooring tiles. Two types of TENG tiles were prepared by using different WPC ratios: 30W:70H and 70W:30H. A static bending test was conducted to assess the flexural …


Harmonic Impedance Modeling And Oscillation Analysis Of Modular Multilevel Converter, Yuhong Wang, Wensheng Chen, Shilin Gao, Jianquan Liao, Yangfan Cheng Dec 2024

Harmonic Impedance Modeling And Oscillation Analysis Of Modular Multilevel Converter, Yuhong Wang, Wensheng Chen, Shilin Gao, Jianquan Liao, Yangfan Cheng

Journal of System Simulation

Abstract: To facilitate rapid analysis of the oscillation stability mechanism in modular multilevel converter-based high voltage direct current (MMC-HVDC) systems and streamline the simulation process for determining MMC impedance characteristics, a simplified mathematical simulation model for MMC closed-loop impedance is developed using the harmonic state space method. This model considers various control strategies and includes both AC-side and DC-side impedance models. By applying a Nyquist criterion-based impedance analysis method, the stability mechanisms on the AC and DC sides of the MMC are examined. In addition, a data-driven oscillation stability analysis method is also proposed, leveraging a global sensitivity algorithm based …


Optimal Operation Scheduling Of Integrated Energy System Considering Energy Priority, Dongli Jia, Keyan Liu, Zhaoying Ren, Zezhou Wang, Dongsheng Tang Dec 2024

Optimal Operation Scheduling Of Integrated Energy System Considering Energy Priority, Dongli Jia, Keyan Liu, Zhaoying Ren, Zezhou Wang, Dongsheng Tang

Journal of System Simulation

Abstract: Integrated with the actual situation of power grid and the growth of new energy, a multiobjective model for optimal scheduling of the integrated energy system(IES) is established based on the analysis of the energy-flow relationship of the IES and taking into account the priority of energy utilization and the load demand response in terms of the mismatch between the distributed energy sources and the loads, the net benefit of the unit cost of the IES, and the load response degree. Combined with the equipment and the environmental benefits system, a priority constraint for energy utilization has been established for …


Research On Scheduling Strategies Simulation For Building Air-Conditioning Systems Based On Transfer Imitation Learning, Qiaochu Wang, Yan Ding, Chuanzhi Liang, Haozheng Zhang, Chen Huang Dec 2024

Research On Scheduling Strategies Simulation For Building Air-Conditioning Systems Based On Transfer Imitation Learning, Qiaochu Wang, Yan Ding, Chuanzhi Liang, Haozheng Zhang, Chen Huang

Journal of System Simulation

Abstract: To solve the problem of unstable performance and inefficient training process of low-quality data conditions at the initial stage of online deployment of air conditioner scheduling, we propose a migration-imitation learning-based air conditioning scheduling strategy simulation method. Reinforcement learning methods are used to generate building operation strategies. A standard building simulation model serves as the source domain, upon which migration learning is applied. An imitation learning loss function is incorporated into the intelligent loss function to enhance algorithm performance. The results indicate that, compared with the non-use of migration learning, the proposed method can improve the operational efficiency by …


Behavioral Modeling Of Manned-Unmanned Cooperative Air Combat Based On Improved Abc Algorithm, Peng Wang, Haoyu Liu, Ni Li, Zexi Yu, Shangjie Jia Dec 2024

Behavioral Modeling Of Manned-Unmanned Cooperative Air Combat Based On Improved Abc Algorithm, Peng Wang, Haoyu Liu, Ni Li, Zexi Yu, Shangjie Jia

Journal of System Simulation

Abstract: To solve the problem of difficulty in establishing collaborative behavior models and weak adversarial capabilities in typical MAV/UAV air combat scenarios, a mixed decision based MAV/UAV behavior modeling framework is proposed. Using collaborative rule sets, rule subsets, tactical action sets, and other tools, a hierarchical decision collaborative behavior model supporting five types of collaborative tactics, including grinding tactics and unilateral flanking tactics, is constructed in this framework. a behavior model parameter optimization method based on an improved artificial bee colony (ABC) algorithm is proposed. By using the Mason rotation method to initialize the population, a better initial honey source …


Path Planning Of Desert Robot Based On Deep Reinforcement Learning, Ming Li, Wangzhong Ye, Jiehua Yan Dec 2024

Path Planning Of Desert Robot Based On Deep Reinforcement Learning, Ming Li, Wangzhong Ye, Jiehua Yan

Journal of System Simulation

Abstract: Due to the complexity and variability of the desert environment, the key to the high-efficient of mobile robot is how to avoid obstacles and plan its path. To solve the problems of poor search efficiency and slow convergence of deep reinforcement learning algorithm in complex environment, an improved deep reinforcement learning path planning algorithm is proposed. The exploration factor is improved and dynamically adjusted according to the convergence degree of the algorithm, so that the exploration factor dynamically decreases with the increase of the understanding degree of the agent to the environment, thus speeding up the convergence speed of …


Effects Of Negative Poisson’S Ratio On The Mechanics Of Auxetic Carbon Fiber Composites Under Tensile, Buckling And Low Velocity Impact, Wenhua Lin Dec 2024

Effects Of Negative Poisson’S Ratio On The Mechanics Of Auxetic Carbon Fiber Composites Under Tensile, Buckling And Low Velocity Impact, Wenhua Lin

Dissertations - ALL

Carbon fiber reinforced polymer (CFRP) matrix composites exhibited superior properties, such as high specific stiffness and specific strength, excellent fatigue and corrosion resistance, and low coefficient of thermal expansion, have been popular across various industries including aerospace, marine, automotive, energy, civil infrastructure, and high-end sports over the past decades. However, one significant drawback of CFRP composites is the susceptibility to low velocity impact damage which, for aircraft, can be results of tool drop, runway debris, and bird strike during takeoff and landing. These impact events could lead to external and internal damages of a CFRP composite structure in various damage …


Thermodynamics And Shear Flow Dynamics Of Block Copolymer Morphologies In Solution, Senyuan Liu Dec 2024

Thermodynamics And Shear Flow Dynamics Of Block Copolymer Morphologies In Solution, Senyuan Liu

Dissertations - ALL

Block copolymers (BCPs) have been a focal point of research for several decades. They have been engineered to produce various morphologies by altering the combinations of chemically distinct polymer segments that interact selectively with their environment, such as in aqueous or organic solvents, or within a polymer matrix. The ability to tailor morphological features by manipulating polymer chain length, composition, and monomer chemistry has led to applications in advanced material manufacturing, catalysis, emulsification, environmental remediation, targeted drug delivery, gene therapy, and medical diagnostics. Consequently, understanding the relationship between copolymer architecture and the self-assembled morphologies at equilibrium, the pathways of structure …


Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang Dec 2024

Pan-Cancer Analysis Of Rna Dysregulation, Somatic Mutations, And Matrix Stiffness Using Bioinformatics Approaches, Gongyu Tang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cancer is a complex disease driven by genetic mutations, epigenetic modifications, and alterations in the tumor microenvironment. Understanding these intricate molecular mechanisms is crucial for advancing cancer diagnosis, prognosis, and treatment. RNA sequencing (RNA-seq) has emerged as a powerful tool to study cancer by providing comprehensive insights into gene expression, alternative splicing, and mutations at the transcriptome level. This dissertation leverages RNA-seq data to explore different dimensions of cancer biology through multi-omics integration and computational approaches. The research is divided into three main projects. First, I developed OncoDB, an interactive database to analyze gene expression, methylation patterns, and viral interactions …


Mems 411: Dbf Wind Tunnel, Jeremy Choh, Stefan Hester, David Howard, Yang Yang Dec 2024

Mems 411: Dbf Wind Tunnel, Jeremy Choh, Stefan Hester, David Howard, Yang Yang

Mechanical Engineering Design Project Class

Design, Build, Fly (DBF) is a student-run engineering team at Washington University in St. Louis (WUSTL) that designs aircraft for flight competitions. Before assembling the final product, DBF runs numerous simulations on prototypes to understand the effects of drag and lift on the designed shape. The lift and drag parameters are important to aircraft design, as DBF hopes to optimize flight performance during competitions. However, simulations require computational power, are theoretical at best, and may inaccurately represent real-life situations. Preferably, DBF can use physical testing that captures prototype performance with more qualitative details.

Senior Design Group Z approaches DBF's needs …


Tensile Strain Validation Of Welded Wire Reinforcement, Alvaro Montes Dec 2024

Tensile Strain Validation Of Welded Wire Reinforcement, Alvaro Montes

Theses and Dissertations

There have been historical concerns regarding the ductility of welded wire reinforcement (WWR). Recent changes in ACI 318-19 now require all grades of A615 and Grade 100 A706 nonprestressed steel reinforcement to have a ratio of tensile strength to yield strength greater than 1.10 and 1.17 respectively. Although this code requirement does not currently apply to WWR, this preemptive study investigated the current state of the art of WWR manufactured in North America in preparation for such a possibility. This project included the tensile-testing of approximately 365 WWR material specimens of various cross-sectional sizes to determine the ratio of tensile-to-yield …


Post-Processing National Water Model Long-Range Forecasts With Random Forest Regression In The Cloud To Improve Forecast Accuracy For Decision-Makers And Water Managers, Jacob Matthew Anderson Dec 2024

Post-Processing National Water Model Long-Range Forecasts With Random Forest Regression In The Cloud To Improve Forecast Accuracy For Decision-Makers And Water Managers, Jacob Matthew Anderson

Theses and Dissertations

Post-processing bias correction of streamflow forecasts can be useful in the hydrologic modeling workflow to fine-tune forecasts for operations, water management, and decision-making. Hydrologic model runoff simulations include errors, uncertainties, and biases, leading to less accuracy and precision for applications in real-world scenarios. We used random forest regression to correct biases and errors in streamflow predictions from the U.S. National Water Model (NWM) long-range streamflow forecasts, considering U.S. Geological Survey (USGS) gauge station measurements as a proxy for true streamflow. We used other features in model training, including watershed characteristics, time fraction of year, and lagged streamflow values, to help …


Local Food System Planning On Multiple Governance Scales: A Grounded Theory Analysis, Decker Ure Dec 2024

Local Food System Planning On Multiple Governance Scales: A Grounded Theory Analysis, Decker Ure

Theses and Dissertations

Local food systems (LFS) comprise the people, policies, infrastructure and practices of food production, distribution, and consumption in localized areas. LFS are becoming an increasingly important part of urban sustainable development and have recently gained significant traction in the urban planning and sustainable community spheres. Worldwide shocks to global food systems such as the COVID-19 pandemic and the Ukraine-Russia war have further elevated global interest in LFS, bringing local food to the forefront of many communities as they try to insulate themselves and their food supply from future risk. However, despite this growing interest in and policy momentum for local …


Harnessing Extrinsic Dissipation To Enhance The Toughness Of Composites And Composite Joints: A State-Of-The-Art Review Of Recent Advances, Gilles Lubineau, Marco Alfano, Ran Tao, Ahmed Wagih, Arief Yudhanto, Xiaole Li, Khaled Almuhammadi, Mjed Hashem, Ping Hu, Hassan A. Mahmoud, Fatih Oz Dec 2024

Harnessing Extrinsic Dissipation To Enhance The Toughness Of Composites And Composite Joints: A State-Of-The-Art Review Of Recent Advances, Gilles Lubineau, Marco Alfano, Ran Tao, Ahmed Wagih, Arief Yudhanto, Xiaole Li, Khaled Almuhammadi, Mjed Hashem, Ping Hu, Hassan A. Mahmoud, Fatih Oz

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Interfaces play a critical role in modern structures, where integrating multiple materials and components is essential to achieve specific functions. Enhancing the mechanical performance of these interfaces, particularly their resistance to delamination, is essential to enable extremely lightweight designs and improve energy efficiency. Improving toughness (or increasing energy dissipation during delamination) has traditionally involved modifying materials to navigate the well-known strength-toughness trade-off. However, a more effective strategy involves promoting non-local or extrinsic energy dissipation. This approach encompasses complex degradation phenomena that extend beyond the crack tip, such as long-range bridging, crack fragmentation, and ligament formation. This work explores this innovative …


Balancing Sustainability Goals And Treatment Efficacy For Pfas Removal From Water, Md Moshiur Rahman Tushar, Zaki Alam Pushan, Nirupam Aich, Stetson Rowles Dec 2024

Balancing Sustainability Goals And Treatment Efficacy For Pfas Removal From Water, Md Moshiur Rahman Tushar, Zaki Alam Pushan, Nirupam Aich, Stetson Rowles

Civil Engineering & Construction: Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are emerging water contaminants with significant environmental and health impacts, posing challenges in water treatment due to their high stability and persistence. With increasing regulations, a critical need remains in understanding the sustainability of PFAS treatment technologies. Our review examines the environmental, economic, and social impacts of current PFAS treatment technologies across different water types and contexts. Additionally, we propose a framework for future sustainability studies to enable more holistic technology evaluations under specific conditions.


The Coalition Development Of Allied Close Air Support Doctrine During World War Ii, David S. Stieghan Dec 2024

The Coalition Development Of Allied Close Air Support Doctrine During World War Ii, David S. Stieghan

Doctoral Dissertations and Projects

This research aims to discover how the American and British air forces worked collaboratively to provide ground support to their armies in Europe during World War II. While the official histories and scholars of the two countries concentrate on their unique national efforts, they analyze little of their cooperative efforts. By examining primary and secondary research sources to discover the experiments, doctrine development, and combat experience of both air forces, an understanding emerges that both nations combined their efforts in World War II in separate directions until beginning to work together on planning for the D-Day invasion.

By discovering the …


Kinetic Modeling Of Bacteria Removal From Suspensions By Magnetic Nanoparticle Capture And Magnetic Separation, Bowen J. Houser Dec 2024

Kinetic Modeling Of Bacteria Removal From Suspensions By Magnetic Nanoparticle Capture And Magnetic Separation, Bowen J. Houser

Theses and Dissertations

This thesis investigates the kinetic modeling of bacteria removal from suspensions using magnetic nanoparticle (MNP) capture and magnetic separation. Functionalized magnetic nanoparticles, especially those coated with polydopamine (pDA), were employed to bind with various bacterial species in phosphate-buffered saline (PBS), apple juice, whole blood, and its components. By analyzing the capture efficiency and kinetics of capture across different bacterial species and mediums, we developed mathematical models describing the capture kinetics of bacteria by the pDA-MNPs. Experimental results demonstrated that pDA-coated MNPs achieved high capture efficiency with certain Gram-positive species like Staphylococcus aureus, and one Gram-negative species, Neisseria perflava; however, capture …


A Computational And Mathematical Approach To The Preclinical Development Of Alpha Emitting Radiopharmaceutical Therapies, Abdulaziz Said Dec 2024

A Computational And Mathematical Approach To The Preclinical Development Of Alpha Emitting Radiopharmaceutical Therapies, Abdulaziz Said

McKelvey School of Engineering Graduate Student Theses & Dissertations

Numerous candidate nuclides have been undergoing rigorous preclinical development in the pursuit of novel targeted therapies. Successful development of these drugs relies on the understanding of physiological impacts at the macro and micro scales, in addition to a scalable process for their production. Here, mathematical and computerized approaches have been developed to guide this preclinical development. In this report, two alpha emitting nuclides Pb-212 and Ra-223 are modeled. Radium-223 dichloride citrate a newly approved ion indicated for treatment of bone metastatic castrate resistant prostate cancer, irradiates lesions through targeted uptake in bone at sites of disease. We have undertaken the …


Safety And Optimality Monitors For Learning-Enabled Systems Using Conformal Prediction, Jackson Cox Dec 2024

Safety And Optimality Monitors For Learning-Enabled Systems Using Conformal Prediction, Jackson Cox

McKelvey School of Engineering Graduate Student Theses & Dissertations

The use of machine learning to create data-driven plant models and controllers has led to an increased need for safety and optimality monitors for model-based systems. System plant models are subject to uncertainty due to learning constraints such as unseen data and overfitting or physical constraints such as unknown dynamics and noise. This uncertainty is detrimental to safety-critical systems and must be properly regulated. To curb this uncertainty, we create prediction sets using the guarantees provided by Conformal Prediction. With a user-specified high probability, these prediction sets contain the true plant system states for an entire prediction horizon, which we …