The Risk Of Bpa In B Lymphocyte-Mediated Autoimmunity,
2026
Liberty University
The Risk Of Bpa In B Lymphocyte-Mediated Autoimmunity, Mario J. Palacios
Senior Honors Theses
Autoimmune disorders disproportionately affect females, a bias largely attributed to estrogen's modulation of B lymphocyte development and tolerance. Bisphenol A (BPA), a common plastic monomer, shows estrogenic activity and acts as an endocrine disruptor and epigenetic modifier. This thesis examines how BPA may increase autoimmune risk by mimicking estrogen such that it can excite estrogen receptors which rescue autoreactive B lymphocytes from apoptosis. While direct research linking BPA to B lymphocyte-mediated autoimmunity is limited, understanding BPA’s course of action in B lymphocytes is critical for addressing the rising prevalence of autoimmune diseases and its possible link to the increased and …
Developing Antibodies Against Galectin-3 And Galectin-9 To Target Endometriosis,
2026
Eastern Washington University
Developing Antibodies Against Galectin-3 And Galectin-9 To Target Endometriosis, Ashleigh Burger, Noah Farnsworth, Jared J. Reisnouer, Cheyenne Vue
2026 Symposium
Endometriosis is a disease characterized by pelvic pain and the formation of endometrial-like tissue on the outside of the uterine lining. This condition affects nearly 10% of women across the globe and confirming whether someone has endometriosis requires visualization in surgery. While the specific causes of this disease remain unclear, the over-expression of the Galectins 3 and 9 in ectopic endometrial tissues suggests a role in the development and maintenance of the condition. Monoclonal antibodies (mAbs) are highly specific proteins with potential as diagnostic or treatment tools. The goal of this study is to generate antibodies against Gal3 and Gal9. …
Myocardin-Dependent Regulation Of Adam12 And Adam19 Promotes Fibronectin Fibrillogenesis During Pleural Fibrosis,
2026
University of Texas at Tyler
Myocardin-Dependent Regulation Of Adam12 And Adam19 Promotes Fibronectin Fibrillogenesis During Pleural Fibrosis, Uday Siva Naga Sankar Allamneni
Biotechnology Theses
Pleural fibrosis involves excessive extracellular matrix (ECM) deposition driven by chronic injury and inflammation. Transforming growth factor-β (TGF-β) induces mesothelial–mesenchymal transition (MesoMT), promoting a myofibroblast phenotype. Our laboratory identified myocardin (Myocd), a transcriptional coactivator, as a key mediator of MesoMT that regulates ECM-remodeling proteases. RNA-seq and qPCR analyses showed that ADAM12 and ADAM19 are upregulated by TGF-β but suppressed by Myocd knockdown in Human pleural mesothelial and IPF-derived cells. Silencing ADAM12 reduced fibrotic markers, including fibronectin and smooth muscle actin (α-SMA), whereas ADAM19 showed relatively minor effects. ADAM12 knockdown also impaired fibronectin fibrillogenesis and insoluble matrix assembly, as confirmed by …
Nanoparticle-Based Therapy For Peripheral Artery Disease: Evaluation Of Collagen Reduction And Fibrosis Mitigation In Ischemic Tissue,
2026
University of Texas at Arlington
Nanoparticle-Based Therapy For Peripheral Artery Disease: Evaluation Of Collagen Reduction And Fibrosis Mitigation In Ischemic Tissue, Tresha Nguyen
2026 Spring Honors Capstones Projects
Peripheral Artery Disease (PAD) is characterized by reduced blood flow, ischemic injury, and fibrosis, which collectively impair tissue function. Current treatment strategies are limited in their ability to target fibrotic tissue and restore normal function effectively. This study evaluates the therapeutic potential of drug-loaded nanoparticles to reduce fibrosis in ischemic tissue. Nanoparticles were synthesized and characterized for in vivo application. Tissue samples from experimental groups, including saline control, blank nanoparticles, free drug, and drug-loaded nanoparticles, were analyzed using Masson’s Trichrome staining to quantify collagen deposition. Histological images were processed using image analysis software to determine the percentage of collagen area. …
Producing Oral Medicines In Lettuce To Fight Chronic Diseases,
2026
Arkansas State University - Jonesboro
Producing Oral Medicines In Lettuce To Fight Chronic Diseases, Carlos E. Balmaceda, Megha Goyal, Anubhav Pal
Create@State
Chronic diseases, such as inflammatory bowel diseases, require patients’ commitment to their treatment, which can be challenging over time. Edible plants could help address this challenge by acting as living factories that produce a range of drugs, including medicinal proteins. Patients could eat the plants because their cells have a sturdy outer layer that protects and helps deliver the medicine. Lettuce is an example of a common vegetable that can serve this purpose. The main goal of this project is to develop a medicinal protein production and oral delivery system using lettuce plants. We will build a small version of …
Role Of Kif4a In The Fxa-Induced Phenotypic Modulation Of Pleural Mesothelial Cells,
2026
University of Texas Health Center at Tyler
Role Of Kif4a In The Fxa-Induced Phenotypic Modulation Of Pleural Mesothelial Cells, Sudishna Khanal
Biotechnology Theses
Pleural injuries can disrupt the organization of the pleural surface, leading to pleural remodeling and fibrosis (PF), characterized by the proliferation of myofibroblasts expressing alpha-smooth muscle actin (α-SMA) and the deposition of extracellular matrix proteins, primarily due to the mesenchymal transition of pleural mesothelial cells (PMCs) (MesoMT). It is well established that various external stimuli, such as TGF-β, thrombin, and factor Xa (FXa), induce MesoMT. Our laboratory found that myocardin, a transcriptional co-activator, was dramatically up-regulated during MesoMT, and that gene silencing of myocardin (MyoCD) diminished MesoMT. RNA sequencing data showed that FXa activated a set of genes not upregulated …
Time And Dose Dependent Effects Of Adipose-Derived Stromal Vascular Fraction Exosomes On Human Dental Pulp Stem Cell Proliferation,
2026
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Time And Dose Dependent Effects Of Adipose-Derived Stromal Vascular Fraction Exosomes On Human Dental Pulp Stem Cell Proliferation, Sylva Dinie Alinda, Anggraini Margono, Indah Julianto, Dini Asrianti Bagio
Journal of Dentistry Indonesia
Background: Cell proliferation is essential for tissue repair and immunomodulation in regenerative dentistry. Adipose-derived stromal vascular fraction (AD-SVF) is a promising autologous source for tissue engineering. Its exosomes (AD-SVF Exo), as cell-free products stable under ischemic conditions, represent an ethical and attractive modality for dental tissue regeneration and broader regenerative applications. Prior study indicates that AD-SVF Exo can enhance human dental pulp stem cell (hDPSC) migration and proliferation, particularly at low concentrations, but their detailed time- and dose-dependent proliferative effects remain unclear. This study aimed to investigate the time- and dose-dependent effects of low-concentration AD-SVF Exo on hDPSC proliferation …
Optimization Of Physalis Angulata L. Callus Induction And Salinity-Induced Antioxidant Production,
2026
Agrotechnology Student, Faculty of Agriculture, Universitas Padjadjaran. Jl. Raya Bandung Sumedang Km 21, Jatinangor, Sumedang 45363, West Java, Indonesia
Optimization Of Physalis Angulata L. Callus Induction And Salinity-Induced Antioxidant Production, Firstian Naufal Sistyananda, Erni Suminar, Anne Nuraini, Muhamad Kadapi, Murgayanti, Syariful Mubarok, Rahmat Budiarto, Eddy Renaldi, Kusumiyati
Jurnal Kultivasi
Groundcherry (Physalis angulata L.) is a plant with many medicinal potentials due to its rich secondary metabolites such as phenolic and flavonoid. However, conventional agriculture practices are still limited, especially in Indonesia. This study was divided into two stages. The first stage was conducted to determine optimal 6-BAP and 2,4-D combination for callus induction, while the second stage was conducted to determine callus phenolic, flavonoid, and antioxidant response to salinity stress. The first stage was arranged in factorial completely randomized design with two factors: 6-BAP (0, 2, and 4 mg/L) and 2,4-D (0, 0.5, 1, and 1.5 mg/L). The second …
Bioactive Constituents And Pharmacological Activities Of Curcuma Zedoaria: A Mini-Review,
2026
Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor Darul Ehsan, Malaysia AND Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia
Bioactive Constituents And Pharmacological Activities Of Curcuma Zedoaria: A Mini-Review, Abdulmutalib Allaq, Muneer M. Saleh Mohammed Saleh Alsayadi, Mustapha Salihu, Hasan M. Agha, Amena Hassan Hassan Gheeth, Fatimah Salim, Norrizah Jaafar Jaafar Sidik
AUIQ Complementary Biological System
Curcuma zedoaria Rosc. (white turmeric) is a rhizomatous medicinal plant in the Zingiberaceae family, widely used in traditional Asian medicine. In recent years, increasing scientific attention has focused on its diverse pharmacological properties and bioactive constituents. This mini review summarises current knowledge of the phytochemical composition and biological activities of C. zedoaria, with particular emphasis on its antimicrobial, antioxidant, anti-inflammatory, and anticancer effects. Phytochemical investigations using analytical techniques such as GC–MS and HPLC have revealed the presence of numerous bioactive compounds, including sesquiterpenes (example, germacrone, curzerenone, and curdione) and curcuminoids, which contribute to its therapeutic potential. Experimental studies demonstrate …
Evaluation Of Circulating Hpg80, Ca15-3, Estrogen And Progesterone As Biomarkers In Breast Cancer Patients,
2026
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad 64021, Iraq
Evaluation Of Circulating Hpg80, Ca15-3, Estrogen And Progesterone As Biomarkers In Breast Cancer Patients, Safa Khaldoon, Emad Yousif, Khawla A. Kasar, Muna Bufaroosha, Rahimi Yusop
AUIQ Complementary Biological System
It is very important to find reliable biomarkers for early detection and monitoring of treatment response because breast cancer is still one of the most common cancers in women around the world. The goal of this study was to find out how clinically important different biochemical markers are in Iraqi women with breast cancer. Some of these signs are progesterone (PG), oestrogen (E2), cancer antigen 15-3 (CA15-3), and circulating progastrin (hPG80). There were 100 women in this study, and they were all between the ages of 20 and 70. There were three groups of people who took part: a healthy …
Synergistic Endocytic Receptor Ligand Receptor Protein 2 In T2dm,
2026
Applied Chemistry Department, College of Applied Science, University of Technology-Iraq
Synergistic Endocytic Receptor Ligand Receptor Protein 2 In T2dm, Wafaa Raji Alfatlawi
AUIQ Complementary Biological System
Purpose: The glycoprotein molecule known as megalin is present on the proximal renal tubular epithelial cells. With an emphasis on megalin and cubilin levels in T2DM and IR patients, an area that obviously needs more research, this study attempts to give an outline of current knowledge of megalin function in relation to vitamin D and its metabolite (vitamin D receptor and vitamin D binding protein). Materials and Methods: This was a case control comparative study conducted at a endocrine and diabetes center in AL-Imamain Kadumain teaching hospital in Baghdad-Iraq. Study subjects were divided into three groups: 25 with T2DM with …
Global Research On Palm Oil Diseases And Infections: A Bibliometric Analysis,
2026
Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research Organization for Health, National Research and Innovation Agency Republic of Indonesia, Serpong 15314, Indonesia
Global Research On Palm Oil Diseases And Infections: A Bibliometric Analysis, Fahmi Achmad Saputra, Indria Puti Mustika, Anna Safarida, Catur Sriherwanto, Nicky Rahmana Putra
Makara Journal of Technology
The sustainability of global palm oil production faces significant threats from a range of diseases and infections affecting palm oil crops. This study presents a comprehensive bibliometric analysis to map the scientific landscape and evolution of research related to palm oil diseases over the past decade. Using data from the Scopus database, 366 relevant documents were analyzed using R and VOSviewer to uncover trends in publication volume, citation impact, prolific authors, country contributions, and keyword co-occurrence networks. The findings reveal a strong research concentration on G. boninense, highlighting its critical role as a persistent pathogen in oil palm plantations. Emerging …
Transgenic Plant Cells For The Cost-Effective Production Of Pharmaceutical Proteins,
2026
Arkansas State University - Jonesboro
Transgenic Plant Cells For The Cost-Effective Production Of Pharmaceutical Proteins, Maria Gambaro
Create@State
Plant-based systems are becoming an important method for producing pharmaceutical proteins because they can be more cost-effective, and safer compared to traditional production methods which commonly use mammalian cells. This project aims to develop a transgenic plant cell system that can produce a pharmaceutical protein using molecular cloning techniques. A transgenic plant cell has the DNA of another plant integrated into its genome, altering its gene expression to produce different proteins. To begin, a plasmid carrying the gene of interest and the DNA components needed for expression will be designed. The plasmid will then be used to introduce the gene …
Impact Of One Nucleotide On Organ Enumeration And Phyllotaxy In Arabidopsis Thaliana,
2026
Fort Hays State University
Impact Of One Nucleotide On Organ Enumeration And Phyllotaxy In Arabidopsis Thaliana, Hazel R. Frans, Tara Phelps-Durr
SACAD: Scholarly Activities
Arabidopsis thaliana is a model organism used by scientists to study plant genetics, development, and physiology. CRISPR-Cas9 is a biotechnology tool adapted from a bacterial defense mechanism to precisely edit DNA using a guide mRNA and a Cas9 protein. This project aims to create CRISPR-CAS9 mutations in the APETALA3 (AP3) gene of the model plant Arabidopsis thaliana. AP3 is a class B gene critical to the petal and stamen development of Arabidopsis flowers. The AP3 protein contains a MADS domain, which binds directly to DNA and may be responsible for the expression of the CaRG-box genes. AP3 works in conjunction …
A Novel Endolysin Of Phage Persinger Infecting Pseudomonas Aeruginosa: Activity Against Biofilms And Structural Prediction,
2026
James Madison University
A Novel Endolysin Of Phage Persinger Infecting Pseudomonas Aeruginosa: Activity Against Biofilms And Structural Prediction, Layla Abbud
James Madison Undergraduate Research Journal (JMURJ)
Endolysins are proteins that degrade bacterial cell walls. They are encoded on the genome of bacteriophages (viruses that infect and kill bacteria). At the end of the lytic cycle of a bacteriophage, endolysins cut the peptidoglycan layer of the bacterial cell wall, allowing the release of viral progeny. Pseudomonas aeruginosa is a well-known multidrug-resistant human pathogen that causes serious problems, especially in patients diagnosed with cystic fibrosis (CF). One property of P. aeruginosa is the production of biofilms, which is a defense against antibiotics. Previous research has shown that endolysins from bacteriophages can degrade biofilms. The endolysin protein from Persinger, …
Verifying Mutations In Arabidopsis Thaliana Gene Apetala3,
2026
Fort Hays State University
Verifying Mutations In Arabidopsis Thaliana Gene Apetala3, Michelle Wang, Tara Phelps-Durr, Hazel Frans
SACAD: Scholarly Activities
The purpose of this research is to verify the mutation in the Arabidopsis thaliana APETALA3 (AP3) gene. By sequencing DNA, we confirmed the presence of an extra guanine in the mutant AP3 gene. These findings support that further investigation is needed into how the AP3 gene affects flower development in Arabidopsis thaliana.
Glioblastoma Multiforme: A Pathologic Breakdown Of One Of Neuro-Oncology's Greatest Challenges,
2026
Thomas Jefferson University
Glioblastoma Multiforme: A Pathologic Breakdown Of One Of Neuro-Oncology's Greatest Challenges, Rosemary Westphal, Ms
Student Papers, Posters & Projects
Glioblastoma multiforme is the most common adult primary tumor with a grim median survival time of 14.6 months. It is characterized by rapid progression, diffuse infiltration, and rather poor clinical outcomes. The WHO classifies GBM as a grade 4 diffuse astrocytic tumor with distinctive histopathological features including high mitotic activity, marked cellular atypia, microvascular proliferation, and necrosis. Advances in molecular diagnostics have further classified GMB into IDH-wild type and IDH-mutant subtypes, with important therapeutic and prognostic implications. Key genetic alterations, such as EGFR amplification, PTEN loss, TP53 mutations, TERT promoter mutations, and MGMT methylations, have been identified as contributing to …
Ellie - Exteroceptive Light Locomotion In Eukaryote-Fungi,
2026
Embry-Riddle Aeronautical University
Ellie - Exteroceptive Light Locomotion In Eukaryote-Fungi, Brandon Etwarroo
Doctoral Dissertations and Master's Theses
Over the past decade, fungal research and its technological applications have expanded across multiple disciplines, including the emerging field of biohybrid systems. This thesis develops and evaluates a wireless, untethered mobile robot controlled by the action potential-like activity generated by Pleurotus ostreatus sporocarps under red, green, and blue optical stimulation. Light is applied to the sporocarps, the resulting electrical responses are recorded, and these signals are transmitted wirelessly to actuate the mobile robot. Both the action potential-like activity patterns and the robot’s movement trajectories were analyzed. The results demonstrate that wireless robotic control mediated by fungal electrophysiology is feasible. Overall, …
Performance Of Membrane Bioreactor In Nitrogen Removal Using Anammox Bacteria Cultivated From Lake Koto Baru,
2026
Department of Environmental Engineering, Universitas Andalas Limau Manis, Padang 25163, Indonesia
Performance Of Membrane Bioreactor In Nitrogen Removal Using Anammox Bacteria Cultivated From Lake Koto Baru, Zulkarnaini Zulkarnaini, Tiffany Azhra Amanda, Alqadri Asri Putra, Puti Sri Komala, Dewi Nilawati, Widyarani Widyarani, Tarzan Sembiring, Panji Cahya Mawarda, Athanasia Amanda Septevani, Mia Miranti Rustama, Rina Andriyani
Makara Journal of Science
Anaerobic ammonium oxidation (anammox) is the biological conversion of ammonium to nitrogen gas (N2) using nitrite as an electron acceptor. This study evaluated the performance of a membrane bioreactor (MBR) in nitrogen removal at room temperature using Candidatus Brocadia fulgida, an anammox bacterium previously cultivated from Lake Koto Baru, Tanah Datar, Indonesia. The MBR was operated for 48 days with a hydraulic retention time of 24 h under a continuous supply of ammonium and nitrite, with both substrates provided at influent concentrations of 70, 150, and 250 mg-N/L. Samples were collected twice a week and analyzed via …
Dietary Oil From Hermetia Illucens L. Larvae Promotes Weight Gain And Alters Leukocyte Profiles In Mus Musculus L,
2026
Animal Physiology, Development, and Molecular Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Mulawarman, Samarinda 75123, Indonesia
Dietary Oil From Hermetia Illucens L. Larvae Promotes Weight Gain And Alters Leukocyte Profiles In Mus Musculus L, Rudy Agung Nugroho Ran, Reni Kurniati, Widya Putri Ambar Sari, Reynaldo Imanuel Sompotan, Retno Aryani, Hetty Manurung, Rudianto Rudianto
Makara Journal of Science
The escalating global demand for high-quality animal-derived proteins has driven the search for sustainable alternatives. Black soldier fly larvae (BSFL; Hermetia illucens L.) oil presents a promising option, by addressing organic waste management while providing nutrient-rich feed. This study evaluated the effects of dietary supplementation with BSFL oil on growth performance, hematological characteristics, and blood lipid profiles in mice (Mus musculus). Male mice were randomly assigned to five groups (n = 5): positive control (fish oil, 5 mL/kg body weight [BW]), negative control (Aquadest, 5 mL/kg BW), and three treatment groups receiving BSFL oil at 2.5, 5, and …
