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Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor 2023 West Virginia University

Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor

Graduate Theses, Dissertations, and Problem Reports

The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge ...


The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review, Cheryl Ratliff 2022 Lesley University

The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review, Cheryl Ratliff

Expressive Therapies Capstone Theses

Empirically based therapies for posttraumatic stress disorder (PTSD) have been found to be less effective in treating more severe trauma presentations such as complex PTSD (CPTSD). Neurobiological investigation provides a framework for examining the physical and psychological effects of trauma on brain and nerve structures and provides insight into how to effectively treat CPTSD. This literature review examined symptomology of CPTSD resulting from complex trauma in childhood, neurobiological effects of trauma and their implications for treatment, and the efficacy of the current treatment models, primarily those of eye movement desensitization and reprocessing (EMDR), narrative exposure therapy (NET), and somatic psychotherapies ...


The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen 2022 Murray State University

The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen

Honors College Theses

The percent of people with mental health disorders in the United States have skyrocketed over the past decade. With stigma surrounding the discussion of mental health and the symptoms associated with it, often those that are suffering do not receive sufficient treatment, as they might with a physical illness. The current, common treatment options for common psychological disorders, like depression, anxiety, and post-traumatic stress disorder, are sometimes not effective in patients, due to resistance or poor response outcomes. Consequently, in order to research alternative therapeutic approaches for mental health disorders, scientists are researching the effects of several hallucinogenic drugs in ...


Nutrient Uptake And Water Quality In Great Salt Lake Wetland Impoundments, Rachel L. Buck 2022 Utah State University

Nutrient Uptake And Water Quality In Great Salt Lake Wetland Impoundments, Rachel L. Buck

All Graduate Theses and Dissertations

The Great Salt Lake (GSL) is the largest inland body of water on the Pacific flyway, a major pathway for migratory birds in the Americas that extends from Alaska to Patagonia. The lake is surrounded by approximately 360,000 acres of wetlands, providing critical food, shelter, cover, nesting areas, and protection to between 4–6 million birds that visit each year. Impounded wetlands were created as part of the GSL ecosystem to support waterfowl habitat. These large, shallow, submergent wetlands are diked to control water levels to sustain aquatic plants which are an important food source. Besides providing critical habitat ...


Associations Between Toxoplasma Gondii Infection And Steroid Hormone Levels In Spotted Hyenas, Zachary M. Laubach, Eben Gering, Erik Yang, Tracy M. Montgomery, Thomas Getty, Kay E. Holekamp 2022 University of Colorado Boulder, Michigan State University, Mara Hyena Project

Associations Between Toxoplasma Gondii Infection And Steroid Hormone Levels In Spotted Hyenas, Zachary M. Laubach, Eben Gering, Erik Yang, Tracy M. Montgomery, Thomas Getty, Kay E. Holekamp

Biology Faculty Articles

Toxoplasma gondii is a common parasite that infects warm-blooded animals and influences host physiology. T. gondii is known to target the host's central nervous system, affecting circulating levels of steroid hormones, fear-related behaviors, and health, although these effects appear to vary among host taxa. Here, we investigated the relationship between T. gondii infection and levels of plasma testosterone and cortisol within a wild population of spotted hyenas (Crocuta crocuta, n = 109). In our analyses, we accounted for age and sex via stratified regression analyses. We detected a negative association between circulating plasma testosterone and T. gondii infection among female ...


Ecological Equivalency Of Living Shorelines And Natural Marshes For Fish And Crustacean Communities, Amanda Guthrie, Donna Marie Bilkovic, Molly Mitchell, Randolph Chambers, Jessica S. Thompson, Robert Isdell 2022 Virginia Institute of Marine Science

Ecological Equivalency Of Living Shorelines And Natural Marshes For Fish And Crustacean Communities, Amanda Guthrie, Donna Marie Bilkovic, Molly Mitchell, Randolph Chambers, Jessica S. Thompson, Robert Isdell

VIMS Articles

Salt marshes provide valued services to coastal communities including nutrient cycling, erosion control, habitat provision for crustaceans and fish (including juvenile and forage fish), and energy transfer from the detrital based food web to the greater estuarine system. Living shorelines are erosion control structures that recreate natural shorelines, such as fringing marshes, while providing other beneficial ecosystem services. Living shorelines are expected to provide fish and crustacean (nekton) habitat, but few comprehensive studies have evaluated nekton habitat use across a range of living shoreline settings and ages. We sampled the intertidal marsh and subtidal shallow water nekton community at 13 ...


Deploying Live Dashboard Data Using Usda Data Apis To Inform Farmers/Producers, Indira Fuyal, Paurakh Paudel, David Zeng 2022 Dakota State University

Deploying Live Dashboard Data Using Usda Data Apis To Inform Farmers/Producers, Indira Fuyal, Paurakh Paudel, David Zeng

SDSU Data Science Symposium

The main objective of this project is to provide the farmers/producers and small business owners with a data intensive information hub to better understand the market trends and patterns in an interactive way to help make informed decisions. This technology is part of a larger project that includes AI powered data services to provide users with decision making support for real time data solutions. Together with Natural Language Generation, there is a huge potential to deploy this technology. In this small demo of this hugely beneficial technology, we make use of the publicly available Open Data Services – ESR Data ...


Poster Session, Emma Beeler, Maddison Caldwell, MacKenzie Paul, Shirli Salihaj, Sara Lynn Sligh, Stephen Trest 2022 Mississippi University for Women

Poster Session, Emma Beeler, Maddison Caldwell, Mackenzie Paul, Shirli Salihaj, Sara Lynn Sligh, Stephen Trest

Mississippi Undergraduate Honors Conference

Poster presenters will discuss their research with attendees in breakout rooms.

Use this link to join the live stream of this event.


Oral Presentations: Stem, Zithlaly Amezquita, Anh Hoang 2022 Mississippi University for Women

Oral Presentations: Stem, Zithlaly Amezquita, Anh Hoang

Mississippi Undergraduate Honors Conference

Each oral presentation of 15 minutes will be followed by Q&A.

Use this link to join the live stream of this event.


Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan 2022 The Graduate Center, City University of New York

Reducing Fear Overgeneralization With Safety Learning: Attention Bias As A Moderator, Boyang Fan

Dissertations, Theses, and Capstone Projects

Anxiety disorders are the most prevalent mental health condition and affect one out of nine individuals around the world. Fear generalization is a neurocognitive mechanism thought to maintain and exacerbate anxiety, and thus is an important target of therapeutic interventions. Yet, intervention research and practice place relatively little emphasis on its importance. Given that a significant proportion of individuals do not respond to extant treatments of anxiety disorders, a strengthened focus on fear generalization may inform the development and personalization of new treatment approaches. Recent notions have linked fear generalization to failures in distinguishing between signals that predict the occurrence ...


Molecular Mechanisms Of Microrna-1205 In Aggressive Prostate Cancer, Michelle K. Naidoo 2022 The Graduate Center, City University of New York

Molecular Mechanisms Of Microrna-1205 In Aggressive Prostate Cancer, Michelle K. Naidoo

Dissertations, Theses, and Capstone Projects

Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men in the United States. High mortality rates of PCa are associated with metastatic castration-resistant prostate cancer (mCRPC) due to the maintenance of androgen receptor (AR) signaling despite androgen deprivation therapies (ADTs). Resistance to second generation ADTs leads to the progression of AR-independent treatment related-neuroendocrine PCa (t-NEPC), which is observed in nearly 1 in 5 men with mCRPC and is associated with very poor outcomes. The 8q24 chromosomal locus is a region of very high PCa susceptibility that carries genetic variants associated with PCa aggressiveness. Located at this ...


Eukaryotic Initiation Factor 3 Interactions With Structural Elements Of Barley Yellow Dwarf Virus Untranslated Regions Reveal Details Of A New Cap-Independent Translation Initiation Model, Paul S. Powell 2022 The Graduate Center, City University of New York

Eukaryotic Initiation Factor 3 Interactions With Structural Elements Of Barley Yellow Dwarf Virus Untranslated Regions Reveal Details Of A New Cap-Independent Translation Initiation Model, Paul S. Powell

Dissertations, Theses, and Capstone Projects

Barley Yellow Dwarf Virus (BYDV) is a positive strand RNA plant virus that translates without using a 5′ 7-methylguanosine cap or a 3′ poly-adenosine tail, features that are required for canonical mRNA translation. BYDV’s non-canonical translation relies on RNA structures in the 5′ and 3′ untranslated regions (UTRs) to recruit eukaryotic initiation factors (eIFs) and ribosomes. BYDV’s 3′ translation enhancer (BTE) is a cruciform structure capable of recruiting the cap-binding complex eIF4F, the large scaffolding complex eIF3, and the 40S ribosomal subunit. Together eIF3, eIF4F, and BTE influence factor binding and 40S recruitment on the 5′ UTR and ...


Novel Strategies For Glutamate Clearance In The Glia-Deprived Synaptic Hub Of C. Elegans, Joyce Chan 2022 The Graduate Center, City University of New York

Novel Strategies For Glutamate Clearance In The Glia-Deprived Synaptic Hub Of C. Elegans, Joyce Chan

Dissertations, Theses, and Capstone Projects

As the major excitatory neurotransmitter in the mammalian brain, Glutamate (Glu) is critical for normal neuronal physiology. Disruption in Glu clearance results in hyper-stimulation of glutamatergic circuits, potentially leading to excitotoxic neurodegeneration. The canonical model of brain connectivity describes glutamatergic synapses as well insulated and enveloped by glia. These glia express Glu Transporters (GluTs) which work to clear Glu following synaptic activity. However, critical areas of the brain such as the mammalian hippocampus display poor synaptic isolation, which may result in Glu spillover between adjacent synapses and subsequent loss of circuit specificity. How accurate signal transmission is achieved in these ...


Histone Post-Translational Modification Dysregulation Contributes To Toxicity In Amyotrophic Lateral Sclerosis Proteinopathy Models, Seth A. Bennett 2022 The Graduate Center, City University of New York

Histone Post-Translational Modification Dysregulation Contributes To Toxicity In Amyotrophic Lateral Sclerosis Proteinopathy Models, Seth A. Bennett

Dissertations, Theses, and Capstone Projects

Amyotrophic Lateral Sclerosis (ALS) is the third most common adult onset neurodegenerative disorder worldwide. It is generally characterized by progressive paralysis starting at the limbs ultimately leading to death caused by respiratory failure. There is no cure and current treatments fail to slow the progression of the disease. As such, new treatment options are desperately needed. Epigenetic targets are an attractive possibility because they are reversible. Epigenetics refers to heritable changes in gene expression unrelated to changes in DNA sequence. Histone modifications, a main epigenetic mechanism, occur in many amino acid residues and include phosphorylation, acetylation, methylation as well as ...


Forage Systems To Optimize Agronomic And Economic Performance In Organic Dairy Systems, S. Ray Smith, G. Pighetti, D. M. Butler, Kenneth H. Burdine, Krista Lea, K. Mercier, K. Payne, J. Allison, Gary E. Bates, N. Colton, A. Rius, P. Krawczel, E. Eckelkamp 2022 University of Kentucky

Forage Systems To Optimize Agronomic And Economic Performance In Organic Dairy Systems, S. Ray Smith, G. Pighetti, D. M. Butler, Kenneth H. Burdine, Krista Lea, K. Mercier, K. Payne, J. Allison, Gary E. Bates, N. Colton, A. Rius, P. Krawczel, E. Eckelkamp

International Grassland Congress Proceedings

Organic dairy production in the USA is growing, but most forage systems research focuses on conventional production practices. As a result, organic dairy producers have limited science-based information to assist with farm and livestock management. The objective of this project was to use a multi-faceted approach to determine the ideal species mixtures for organic dairy production as well as document forage quality, forage yield, soil characteristics, milk production and milk quality during the grazing season. The forages studied ranged from a single species monoculture to a four species mixture of warm and cool season grasses and legumes. Nine distinct forage ...


Fodder Crop Adoption Through Push-Pull Technology (Ppt) For Fall Armyworm (Faw) Control In Cereals Cropping Systems, Michael N. Njunie, E. N. Muthiani, A. Mzingirwa, N. F. Pole, B. M. Muli, A. O. Esilaba 2022 Kenya Agricultural and Livestock Research Organisation, Kenya

Fodder Crop Adoption Through Push-Pull Technology (Ppt) For Fall Armyworm (Faw) Control In Cereals Cropping Systems, Michael N. Njunie, E. N. Muthiani, A. Mzingirwa, N. F. Pole, B. M. Muli, A. O. Esilaba

International Grassland Congress Proceedings

There is an urgent need to increase grain yields and animal products due to increasing human population in Africa. Push-pull technology (PPT) is a conservation agriculture intercrop technology which protects and enhances natural resources productivity and ecosystem services in mixed farming systems. The technology involves growing of a cereal crop with a repellent intercrop, Desmodium genus (silverleaf, D. uncinatum and greenleaf, D. intortum) with grass such as Pennisetum purpureum or Brachiaria spp. planted as a border around the cereal-legume intercrop. The plants accompanying the cereal crop are typically valuable high quality fodder thus integrating crop-livestock production. The PPT was initially ...


Evaluation Of The Chemical And Biological Characteristics Of Sake Lees, S. Katsumata, S. Yamanaka, M. Yamauchi, H. Hirooka, H. Kumagai 2022 Kyoto University, Japan

Evaluation Of The Chemical And Biological Characteristics Of Sake Lees, S. Katsumata, S. Yamanaka, M. Yamauchi, H. Hirooka, H. Kumagai

International Grassland Congress Proceedings

Sake lees (SLs), produced from brewing Japanese Sake and known to be rich in yeast, is expected to be an alternative of feed protein sources for ruminants. Previous studies showed that yeast improved the digestibility of fibers in ruminants. However, the nutrient composition and the numbers of live and dead yeast in the SLs, have large diversity because of the different brewing materials and processes. The objective of this study was to evaluate the chemical and biological characteristics of SLs with diverse brewing processes and storing periods (0-23 weeks). Seven types of SLs (SLs 1-7) were collected from two breweries ...


Effect Of High-Intensity, Short-Duration Grazing On Species Density And Botanical Composition Of Arid Rangelands, Mounir Louhaichi, Mouldi Gamoun, Fethi Gouhis, Ezzeddine Belfekih, Mohamed Abdelkader 2022 International Centre for Agricultural Research in the Dry Areas

Effect Of High-Intensity, Short-Duration Grazing On Species Density And Botanical Composition Of Arid Rangelands, Mounir Louhaichi, Mouldi Gamoun, Fethi Gouhis, Ezzeddine Belfekih, Mohamed Abdelkader

International Grassland Congress Proceedings

Rangelands are the mainstay of pastoral and agropastoral livelihoods worldwide. They have provided forage for livestock and wildlife for centuries, but steady degradation of rangelands is causing increasing concern. Many rangeland managers believe exclusion of livestock grazing for extended periods would allow degraded rangelands to recover. The purpose of this current ongoing research is to evaluate the effect of high-intensity short-duration grazing on plant density, species richness and botanical composition on arid rangelands during favorable years. The site, which is protected for two years in southern Tunisia and covers an area of 6 ha, was grazed by a flock of ...


Economics Of Greenhouse Gas Mitigation Strategies In A North-Eastern Brazilian Beef Production System, K. Agethen, Rogerio M. Mauricio, C. Deblitz 2022 Thünen Institute of Farm Economics, Germany

Economics Of Greenhouse Gas Mitigation Strategies In A North-Eastern Brazilian Beef Production System, K. Agethen, Rogerio M. Mauricio, C. Deblitz

International Grassland Congress Proceedings

The state of Maranhão, Brazil, has been among the country’s fastest-growing cattle regions in recent years and it now faces important conflicts for beef production. Pasture degradation, low cattle productivity, and land-use changes due to agriculture and forestry expansion are key challenges. Additionally, beef production systems are a focus for emissions reduction, particularly in the context of increasing deforestation and its impact on global warming. A sustainable intensification of currently used pastures, enhancing economic viability and reducing environmental effects of beef production can help to mitigate the climate impact. Since economics is an important incentive in the decision-making processes ...


Muscle Activity And User-Perceived Exertion During Immersive Virtual Reality Exergaming Incorporating An Adaptive Cable Resistance System, David Gomez, Jonathan D. Browne, Abdulrahman Almalouhi, Max Abundex, Jonathan Hu, Sally Nason, Nicholas Kull, Cade Mills, Quincy Harris, Richard Ku, Eric V. Neufeld, Brett A. Dolezal, PhD 2022 Airway & Exercise Physiology Research Laboratory, David Geffen School of Medicine, University of California Los Angeles

Muscle Activity And User-Perceived Exertion During Immersive Virtual Reality Exergaming Incorporating An Adaptive Cable Resistance System, David Gomez, Jonathan D. Browne, Abdulrahman Almalouhi, Max Abundex, Jonathan Hu, Sally Nason, Nicholas Kull, Cade Mills, Quincy Harris, Richard Ku, Eric V. Neufeld, Brett A. Dolezal, Phd

International Journal of Exercise Science

International Journal of Exercise Science 15(7): 232-246, 2022. The purpose of this exploratory study was to characterize muscle activation via surface electromyography (sEMG), user-perceived exertion, and enjoyment during a 30-minute session of immersive virtual reality (IVR) cable resistance exergaming. Ten healthy, college-aged males completed a signature 30-minute exergaming session using an IVR adaptive cable resistance system that incorporated six traditional compound exercises. Muscle activation (sEMG) was captured during the session with a wearable sEMG system. Rated of Perceived Exertion (RPE) and Physical Activity Enjoyment Scale (PACES) were recorded following the session. Pectoralis major showed the highest activation during chest ...


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