The Effects Of Host-Like Environmental Signals And Gene Expression On Capsule Growth In Cryptococcus Neoformans,
2022
Washington University in St. Louis
The Effects Of Host-Like Environmental Signals And Gene Expression On Capsule Growth In Cryptococcus Neoformans, Yu Min Jung
McKelvey School of Engineering Theses & Dissertations
Cryptococcus neoformans is a fungal pathogen that causes cryptococcosis, a disease that kills almost 200,000 people worldwide each year. A unique feature of this deadly yeast is its polysaccharide capsule, which is known to be associated with its virulence. Here, we systematically explore the effects of all possible combinations of 4 capsule-inducing signals on gene expression, cell size, and capsule size. These signals are medium (YPD, DMEM or RPMI), temperature (30°C or 37°C), CO2 (room air or 5%), cAMP (0 mM or 20 mM), and pH buffer (HEPES/no HEPES). We explore the effects of exogenous ...
Inferring Dynamics Of Biological Systems,
2022
George Mason University
Inferring Dynamics Of Biological Systems, Tracey G. Oellerich
Biology and Medicine Through Mathematics Conference
No abstract provided.
Combining Pharmacokinetics And Vibrational Spectroscopy: Mcr-Als Hard-And-Soft Modelling Of Drug Uptake In Vitro Using Tailored Kinetic Constraints,
2022
Technological University Dublin
Combining Pharmacokinetics And Vibrational Spectroscopy: Mcr-Als Hard-And-Soft Modelling Of Drug Uptake In Vitro Using Tailored Kinetic Constraints, David Perez-Guaita, Guillermo Quintas, Zeineb Farhane, Roma Tauler, Hugh Byrne
Articles
Raman microspectroscopy is a label-free technique which is very suited for the investigation of pharmacokinetics of cellular uptake, mechanisms of interaction, and efficacies of drugs in vitro. However, the complexity of the spectra makes the identification of spectral patterns associated with the drug and subsequent cellular responses difficult. Indeed, multivariate methods that relate spectral features to the inoculation time do not normally take into account the kinetics involved, and important theoretical information which could assist in the elucidation of the relevant spectral signatures is excluded. Here, we propose the integration of kinetic equations in the modelling of drug uptake and ...
Multi-Omic Systems Biological Analysis Of Host-Microbe Interactions,
2022
University of Tennessee, Knoxville
Multi-Omic Systems Biological Analysis Of Host-Microbe Interactions, Piet Jones
Doctoral Dissertations
Systems biology offers the opportunity to understand the complex mechanisms of various biological phenomena. The wealth of data that is produced, at an increasing rate, provides the potential to meet this opportunity. Here we take an applied approach to integrate multiple omic level data sources in order to generate biologically relevant hypotheses. We apply a novel analysis pipeline to model both, in concert, the microbial and transcriptomic signature from COVID-19 positive patients. We show patients may suffer from an increased microbial burden, with an increased pathogen potential. Gene expression evidence further shows patients may exhibit a compromised barrier immunity, owing ...
Effective Dose Fractionation Schemes Of Radiotherapy For Prostate Cancer,
2022
University of California, Riverside
Effective Dose Fractionation Schemes Of Radiotherapy For Prostate Cancer, Jose Alvarez, Kathleen M. Storey, Pavitra Kannan, Heyrim Cho
Spora: A Journal of Biomathematics
Radiation therapy remains as one of the main cancer treatment modalities. Typical regimens for radiotherapy comprise a constant dose administered on weekdays, and no radiation on weekends. In this paper, we examine adaptive dosages of radiation treatment strategies for heterogeneous tumors using a dynamical system model that consist of radiation-resistant and parental populations with unique interactive properties, namely, PC3 and DU145 prostate cancer cell lines. We show that stronger doses of radiation given in longer time intervals, while keeping the overall dosage the same, are effective in PC3 cell lines, but not in DU145 cell lines. In addition, we tested ...
Effects Of Foliar Application Of Zno Nanoparticles On Lentil Production, Stress Level And Nutritional Seed Quality Under Field Conditions,
2022
Slovak University of Agriculture
Effects Of Foliar Application Of Zno Nanoparticles On Lentil Production, Stress Level And Nutritional Seed Quality Under Field Conditions, Marek Kolenčík, Dávid Ernst, Matej Komár, Martin Urík, Martin Šebesta, Ľuba Ďurišová, Marek Bujdoš, Ivan Černý, Juraj Chlpík, Martin Juriga, Ramakanth Illa, Yu Qian, Huan Feng, Gabriela Kratošová, Karla Čech Barabaszová, Ladislav Ducsay, Elena Aydın
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
Nanotechnology offers new opportunities for the development of novel materials and strategies that improve technology and industry. This applies especially to agriculture, and our previous field studies have indicated that zinc oxide nanoparticles provide promising nano-fertilizer dispersion in sustainable agriculture. However, little is known about the precise ZnO-NP effects on legumes. Herein, 1 mg·L−1 ZnO-NP spray was dispersed on lentil plants to establish the direct NP effects on lentil production, seed nutritional quality, and stress response under field conditions. Although ZnO-NP exposure positively affected yield, thousand-seed weight and the number of pods per plant, there was no statistically ...
Second Twenty-Five Year Index: Volumes 26–50, 1994–2018,
2022
Editor, The Prairie Naturalist
Second Twenty-Five Year Index: Volumes 26–50, 1994–2018, Jane E. Austin
The Prairie Naturalist
The first 50 years of the Prairie Naturalist reside on the shelves of libraries and personal collections. The articles and notes published over those years provide invaluable knowledge about Great Plains biota, communities, conservation, and landscape ecologies. Awareness of the wealth of information in those 50 print volumes has been limited, relying on references from other published papers or the limited number of articles that have been made available online by authors. This index serves as resource for individuals to digitally tap into the information published since 1994. This index, together with the first 25-year index, serves to complement the ...
Evaluating Common Raven Take For Greater Sage-Grouse In Oregon’S Baker County Priority Conservation Area And Great Basin Region,
2022
U.S. Fish and Wildlife Service
Evaluating Common Raven Take For Greater Sage-Grouse In Oregon’S Baker County Priority Conservation Area And Great Basin Region, Frank F. Rivera-Milán, Peter S. Coates, Jacqueline B. Cupples, Michael Green, Patrick K. Devers
Human–Wildlife Interactions
The common raven (Corvus corax; raven) is a nest predator of species of conservation concern, such as the greater sage-grouse (Centrocercus urophasianus). Reducing raven abundance by take requires authorization under the Migratory Bird Treaty Act. To support U.S. Fish and Wildlife Service’s take decisions (e.g., those that authorize killing a specified proportion or number of individuals annually in a defined area), including the most recent one for Oregon’s Baker County Priority Area for Conservation (PAC), we modeled raven population dynamics under hypothetical scenarios with take rates ranging from below to above the maximum sustained yield (MSY ...
Convergence Properties Of Solutions Of A Length-Structured Density-Dependent Model For Fish,
2021
University of Nebraska, Lincoln
Convergence Properties Of Solutions Of A Length-Structured Density-Dependent Model For Fish, Geigh Zollicoffer
Rose-Hulman Undergraduate Mathematics Journal
We numerically study solutions to a length-structured matrix model for fish populations in which the probability that a fish grows into the next length class is a decreasing nonlinear function of the total biomass of the population. We make conjectures about the convergence properties of solutions to this equation, and give numerical simulations which support these conjectures. We also study the distribution of biomass in the different age classes as a function of the total biomass.
A Dystrophin Exon‐52 Deleted Miniature Pig Model Of Duchenne Muscular Dystrophy And Evaluation Of Exon Skipping,
2021
George Washington University
A Dystrophin Exon‐52 Deleted Miniature Pig Model Of Duchenne Muscular Dystrophy And Evaluation Of Exon Skipping, Yusuke Echigoya, Nhu Trieu, William Duddy, Hong M. Moulton, Haifang Yin, Terence A. Partridge, Eric P. Hoffman, Joe N. Kornegay, Frank A. Rohret, Christopher S. Rogers, Toshifumi Yokota
Genomics and Precision Medicine Faculty Publications
No abstract provided.
The Mayfly Newsletter,
2021
Southwestern Oklahoma State University
The Mayfly Newsletter, Donna Giberson
The Mayfly Newsletter
The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.
Analytical Considerations And Methods For Comprehensive Analysis Of Bacterial Phospholipidomics Using Hilic-Ms/Ms,
2021
University of Tennessee, Knoxville
Analytical Considerations And Methods For Comprehensive Analysis Of Bacterial Phospholipidomics Using Hilic-Ms/Ms, David Thomas Reeves
Doctoral Dissertations
Omics technologies have rapidly evolved over the last half century through vast improvements in efficient extraction methodologies, advances in instrumentation for data collection, and a wide assortment of informatics tools to help deconvolute sample data sets. However, there are still untapped pools of molecules that warrant further analytical attention. As the frontline defense of the cell against exterior influences, the phospholipid membrane is key in structure, defense, and signaling, but current omics studies are only just now catching up to the potential hidden within cellular lipid profiles. Examination of shifts in phospholipid speciation and character could provide researchers with a ...
Physical Models Of Living Systems Prologue: A Breakthrough On Hiv,
2021
University of Pennsylvania
Physical Models Of Living Systems Prologue: A Breakthrough On Hiv, Philip C. Nelson
Department of Physics Papers
No abstract provided.
Machine Learning-Based Risk Factor Analysis And Prevalence Prediction Of Intestinal Parasitic Infections,
2021
Illinois State University
Machine Learning-Based Risk Factor Analysis And Prevalence Prediction Of Intestinal Parasitic Infections, Ahmet Ay
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Identification Of Control Targets In Boolean Networks Via Computational Algebra,
2021
University of Dayton
Identification Of Control Targets In Boolean Networks Via Computational Algebra, Alan Veliz-Cuba
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Building Model Prototypes From Time-Course Data,
2021
University of Kentucky
Building Model Prototypes From Time-Course Data, David Murrugarra, Alan Veliz-Cuba
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Neural Network Controller Vs Pulse Control To Achieve Complete Eradication Of Cancer Cells In A Mathematical Model,
2021
Tijuana Institute of Technology, México
Neural Network Controller Vs Pulse Control To Achieve Complete Eradication Of Cancer Cells In A Mathematical Model, Joel A. Quevedo, Sergio A. Puga, Paul A. Valle
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Chemoimmunotherapy Treatment Strategies On A Mathematical Model Of Cancer Evolution,
2021
Tijuana Institute of Technology, México
Chemoimmunotherapy Treatment Strategies On A Mathematical Model Of Cancer Evolution, Sandra M. Lopez, Yolocuauhtli Salazar, Paul A. Valle
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Mathematical Model Describing The Behavior Of Biomass, Acidity, And Viscosity As A Function Of Temperature In The Shelf Life Of Yogurt,
2021
Durango Institute of Technology, México
Mathematical Model Describing The Behavior Of Biomass, Acidity, And Viscosity As A Function Of Temperature In The Shelf Life Of Yogurt, Manuel Alvarado, Paul A. Valle, Yolocuauhtli Salazar
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
The Role Of Mathematics In 21st Century Medicine,
2021
Illinois State University
The Role Of Mathematics In 21st Century Medicine, Reinhard Laubenbacher
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.