Zebrafish Electroretinogram Responses,
2024
The University of Akron
Zebrafish Electroretinogram Responses, Brooke Campbell
Williams Honors College, Honors Research Projects
The goal of this project is to be able to streamline a protocol for conducting ERGs on zebrafish from mice ERG protocol already present in Dr. Renna’s lab. The objective is to create a protocol specifically for zebrafish and to eliminate any issues that occur when transiting from a mice ERG protocol to a zebrafish ERG protocol and to obtain a light response from zebrafish retinae in differing light intensities. Dr. Renna’s lab has designed an Ex Vivo ERG system with less electrical interference creating defined electrical responses from mouse retina. The setup allows for continual perfusion of the retinal …
Community-Derived Core Concepts For Neuroscience Higher Education,
2023
College of Saint Benedict/Saint John's University
Community-Derived Core Concepts For Neuroscience Higher Education, Audrey Chen, Kimberley A. Phillips, Jennifer E. Schaefer, Patrick M. Sonner
Biology Faculty Publications
Core concepts provide a framework for organizing facts and understanding in neuroscience higher education curricula. Core concepts are overarching principles that identify patterns in neuroscience processes and phenomena and can be used as a foundational scaffold for neuroscience knowledge. The need for community-derived core concepts is pressing, because both the pace of research and number of neuroscience programs are rapidly expanding. While general biology and many subdisciplines within biology have identified core concepts, neuroscience has yet to establish a community-derived set of core concepts for neuroscience higher education. We used an empirical approach involving more than 100 neuroscience educators to …
The Role Of Complement In Stroke And Traumatic Brain Injury,
2023
Medical University of South Carolina
The Role Of Complement In Stroke And Traumatic Brain Injury, Christine Couch
MUSC Theses and Dissertations
Brain and neural injury are a non-specific disease category that includes traumatic brain injury (TBI) and stroke. Both TBI and stroke are common, costly, and leading causes of severe disability in adults. Both stroke and TBI are responsible for substantial disability in working age adults, with stroke being the second leading cause of death worldwide [1] and TBI a major cause of disability in people younger than their 40's [2]. The immune response after brain injury is multifactorial and involves both local and systemic events at the cellular and molecular level. The complement system is a component of both the …
Examining The Use Of Expressive Arts Therapies In Neurorehabilitation Treatment Planning,
2023
Lesley University
Examining The Use Of Expressive Arts Therapies In Neurorehabilitation Treatment Planning, Rebecca J. Horner
Expressive Therapies Capstone Theses
Those undergoing neurorehabilitation after stroke and traumatic brain injury report a diminished sense of overall wellness. This paper examines the conceivable benefits of introducing expressive arts therapies, which is the therapeutic use and combination of the visual arts, movement, drama, music, writing and other intermodal creative processes, into physical therapy and neurorehabilitation treatment planning. Expressive arts therapies have the capacity to engage with an individual’s physical, emotional, social and spiritual states concurrently. They simultaneously offer the ability to promote an increased sense of well-being, address mind-body disconnects, and process trauma non-verbally.
The sections of this narrative literature review focus on …
Computing Brain Networks With Complex Dynamics,
2023
State University of New York at New Paltz
Computing Brain Networks With Complex Dynamics, Anca R. Radulescu
Biology and Medicine Through Mathematics Conference
No abstract provided.
Gap Junctions And Synchronization Clusters In The Thalamic Reticular Nuclei,
2023
State University of New York at New Paltz
Gap Junctions And Synchronization Clusters In The Thalamic Reticular Nuclei, Anca R. Radulescu, Michael Anderson
Biology and Medicine Through Mathematics Conference
No abstract provided.
Optical Perturbation Of Protein Kinase A Activity Via Photoactivatable Inhibitor Peptides,
2023
Washington University in St. Louis
Optical Perturbation Of Protein Kinase A Activity Via Photoactivatable Inhibitor Peptides, Peter Chen
McKelvey School of Engineering Theses & Dissertations
Protein Kinase A (PKA) plays important roles in diverse biological processes such as sleep, long term memory, and synaptic plasticity. In addition, PKA also acts as an integrator of neuromodulator signaling though G protein-coupled receptor activation. However, despite genetic knockout and pharmacological inhibition experiments that demonstrate the importance of PKA, it is unclear where, when, or how PKA plays these roles in cellular physiology and behavior. In order to better understand the function of PKA in these processes, and how neuromodulator signaling drives complex behavioral changes, there exists a need for a method to selectively activate/inactivate PKA with high spatial …
Preparing Non-Human Primates To Study Hand-Eye Coordination In Frontal Eye Fields (Fef) During Delayed Movement Task,
2023
Washington University in St. Louis
Preparing Non-Human Primates To Study Hand-Eye Coordination In Frontal Eye Fields (Fef) During Delayed Movement Task, Juliusz Cydzik
McKelvey School of Engineering Theses & Dissertations
ABSTRACT OF THE THESIS Preparing Non-Human Primates to Study Hand-Eye Coordination in Frontal Eye Fields (FEF) During Delayed Movement Task by Juliusz Cydzik Master of Science in Biomedical Engineering Washington University in St. Louis, 2023 Professor Lawrence Snyder, Chair Hand-eye coordination enables humans and non-human primates to use their hands and eyes to perform various tasks. We are interested in coordination at the systems level, where saccades and reaches are encoded. The parietal reach region (PRR), situated at the posterior end of the intraparietal sulcus (IPS) and overlapping portions of the medial intraparietal area (MIP) and V6a, is commonly attributed …
Eco-Interoception: What Plants, Fungi And Protista Have Taught My Body,
2023
Southern Methodist University
Eco-Interoception: What Plants, Fungi And Protista Have Taught My Body, Sara Riley Dotterer
Art Theses and Dissertations
To me, ecology is the relational, full-body awareness that I am made up of and deeply connected to everything around me; and for better or worse, this is reciprocal. I form ecotones, an ecological transitional zone between two ecosystems, with the world around me. I use this ecotonal lens to blur binaries and dissolve boundaries between me and the world “outside my body.” During my Masters of Fine Arts at Southern Methodist University, I have continuously explored and represented the lives of various more-than-human species outside of my body, including plants, fungi and protista through an ecotonal lens. Although these …
Consolidated Chamber Design And Protocol For Olfactory Conditioning Assay With Drosophila Melanogaster,
2023
Georgia Institute of Technology
Consolidated Chamber Design And Protocol For Olfactory Conditioning Assay With Drosophila Melanogaster, Sasha Bronovitskiy, Andres Castillo, Michael Yan, Fang Ju Lin
Journal of the South Carolina Academy of Science
The olfactory conditioning assay is widely used in Alzheimer’s disease research to quantify learning and memory in Drosophila melanogaster. The assay tests ability to recall an aversive conditioned stimulus of scent paired with electrical shock when presented a choice between shock-associated and unrelated scents. The T-maze, a commonly used apparatus for olfactory conditioning assays, employs an elevator mechanism to transfer live flies from the shock-delivering training chamber to the scent selection point. This elevator mechanism is known to cause fly casualty. T-mazes are not commercially available and often difficult to reproduce. Other existing variations of olfactory conditioning apparatuses use …
Do Plants Have The Cognitive Complexity For Sentience?,
2023
ICREA-Universitat Pompeu Fabra
Do Plants Have The Cognitive Complexity For Sentience?, Ricard V. Solé
Animal Sentience
Are plants sentient? Like other aspects of the cognitive potential of plants, this is a controversial issue, often driven by analogies and seldom supported on solid theoretical grounds. Sentience is understood in cognitive sciences as the capacity to feel. I suggest that because of plants’ evolved adaptations to morphological plasticity, sessile nature and ecological constraints, they are unlikely to have the requisite cognitive complexity for sentience.
Perinatal Experiences Of People With Autism Spectrum Disorders: A Preliminary Scoping Review,
2023
Rowan University
Perinatal Experiences Of People With Autism Spectrum Disorders: A Preliminary Scoping Review, Tanvi Shah, Andrea Iannuzzelli, Venkateswar Venkataman
Stratford Campus Research Day
Autism Spectrum Disorder (ASD) is a developmental disorder that is diagnosed in early childhood, typically in people who are assigned male at birth. However, this diagnosis and the sensory and behavioral divergence that comes with ASD stay with people throughout their lives. Based on the DSM-V diagnostic criteria and the history of how Autism and Autism Spectrum Disorders were first identified, many people who do not identify as male and/or present atypically do not receive a formal diagnosis until later in life or self-diagnose. This in turn has led to a lack of research in both populations that do not …
Swallowing Disrupts Tongue-Jaw Coordination During Chewing In A Rat Model Of Parkinson's Disease,
2023
Rowan University
Swallowing Disrupts Tongue-Jaw Coordination During Chewing In A Rat Model Of Parkinson's Disease, Meejan Palhang, N. Charles, Francois Gould
Stratford Campus Research Day
The primary motor symptoms of Parkinson’s disease, including bradykinesia, rigidity, and tremor, are associated with difficulties regulating transitions between motor behaviors due to basal ganglia dysfunction. Chewing and swallowing, which are disordered in most patients with Parkinson’s disease, are two complex motor behaviors which overlap in time and share some neuromuscular components. The objective of this study is to identify how Parkinson’s disease affects the coordination of chewing and swallowing. We hypothesize that as a result of impaired regulation of shift between motor patterns, chewing cycles that occur with a swallow will be more affected that chewing cycles occurring in …
Extravasated Brain-Reactive Autoantibodies Perturb Neuronal Surface Protein Expression In Alzheimer's Pathology,
2023
Rowan University
Extravasated Brain-Reactive Autoantibodies Perturb Neuronal Surface Protein Expression In Alzheimer's Pathology, Wardah Bajwa, Mary Kosciuk, Randel L. Swanson, Anuradha Krishnan, Venkat Venkataraman, Robert Nagele, Nimish Acharya
Stratford Campus Research Day
Background: Increased blood-brain barrier (BBB) permeability is reported in both the neuropathological and in vivo studies in both Alzheimer’s Disease (AD) and age matched cognitively normal, no cognitive impairment (NCI), subjects. Impaired BBB allows various vascular components such as immunoglobulin G (IgG) to extravasate into the brain and specifically bind to various neuronal surface proteins (NSP), also known as brain reactive autoantibodies (BrABs). This interaction is predicted to further enhance deposition of amyloid plaques.
Hypothesis: Interaction between extravasated BrABs and its cognate NSPs lower the expression of that NSPs in AD patients.
Methods: We selected Western blotting technique to study …
Discovering Distinct Patterns Of Alpha Activity In Adults With Inattentive Adhd Using Electroencephalography,
2023
DePauw University
Discovering Distinct Patterns Of Alpha Activity In Adults With Inattentive Adhd Using Electroencephalography, Lucy Salter '23
Senior Research Symposium
According to data collected and analyzed by researchers, it has been estimated that roughly 8.7 million adults live with attention-deficit/hyperactivity disorder (ADHD), resulting in an estimated $122.8 billion in excess societal costs due to increased healthcare costs, unemployment, and loss of productivity all of which are linked to ADHD symptoms (Schein et al., 2022). Additionally, literature suggests that adult ADHD is associated with increased risk of imprisonment and substance abuse, decreased educational achievement, increased comorbid psychiatric conditions, and poorer clinical outcomes (Ginsberg et al., 2014). Although there is a relatively clearer understanding about ADHD in adolescents, particularly the hyperactive ADHD …
The Effects Of Loss Of Orexin Neurons On Attention,
2023
William & Mary
The Effects Of Loss Of Orexin Neurons On Attention, Alejandra Eceizabarrena Sainz
Undergraduate Honors Theses
Attention is the ability to process stimuli in the environment and select relevant cues amongst distractors. It is a crucial aspect of the nervous system that engages multiple brain circuits. Neurons that release the neuropeptide orexin are implicated in attention. These neurons originate in the lateral hypothalamus and send projections widely throughout the brain. Evidence suggests orexins modulate attentional mechanisms through interactions with ascending neuromodulatory systems such as the basal forebrain. Experiments manipulating orexin receptors have found a subsequent effect on attention-demanding tasks, with infusions of orexin A enhancing attention in the presence of distractors. In contrast, the blockade of …
Improving Traumatic Brain Injury Outcomes: Early Identification And Management Of Paroxysmal Sympathetic Hyperactivity,
2023
Southern Illinois University Edwardsville
Improving Traumatic Brain Injury Outcomes: Early Identification And Management Of Paroxysmal Sympathetic Hyperactivity, Randi Rockwell
Doctor of Nursing Practice Projects
Abstract
Background: Paroxysmal sympathetic hyperactivity (PSH) can occur in patients with acutely acquired brain injury and is associated with mortality, poor clinical outcomes, prolonged hospitalizations, physical disability, and increased healthcare costs. The most common cause of PSH syndrome is traumatic brain injury (TBI). Symptoms consist of hyperthermia, diaphoresis, arterial hypertension, tachycardia, tachypnea, and extremity motor dystonic posturing, often in response to evoked stimuli and occurs in 8% to 33% of TBI patients. Critical care nurses are at the forefront of providing direct patient care to TBI patients and are often the first to identify PSH.
Purpose: The objective of this …
Adolescents With Family History Of Alcohol-Use Disorders Have Reduced Structural Coherence Of Anterior Insula To Nucleus Accumbens Tract,
2023
University of Arkansas, Fayetteville
Adolescents With Family History Of Alcohol-Use Disorders Have Reduced Structural Coherence Of Anterior Insula To Nucleus Accumbens Tract, Grace Wood
Psychological Science Undergraduate Honors Theses
Genetics play a significant role in predisposition towards alcohol use disorders. Analyzing the neural phenotypes related to alcohol use disorder development could allow researchers to predict one’s predisposition. The anterior insula (AIns) contributes to binge drinking tendencies while exhibiting downstream signaling towards the nucleus accumbens (NAcc). Recent research has examined this relationship simultaneously with alcohol consumption, but the genetic effect of the AIns and NAcc functional relationship prior to alcohol consumption has yet to be examined. In this study, we used data from the Adolescent Brain Cognitive Development (ABCD) study to analyze the structural coherence of the AIns to NAcc …
Early Life Stress Predicts Future Conduct Disorder In Adolescents,
2023
University of Arkansas, Fayetteville
Early Life Stress Predicts Future Conduct Disorder In Adolescents, Savannah Ellis
Biological Sciences Undergraduate Honors Theses
Early Life Stress (ELS) and adversity increase people’s risk for developing mental, social, or emotional dysregulation and disorders later in life. The objective of this study was to test whether ELS in adolescents could prospectively predict future conduct disorder. The study additionally tested potential neural mediators of the effect of ELS on future conduct disorder, and specifically targeted the structural connections from the anterior insula and medial prefrontal cortex to the Nucleus Accumbens (NAcc). Data for the project came from the Adolescent Brain Cognitive Development Study (ABCD study), which is a longitudinal multi-site consortium funded by the National Institutes of …
Music & Synesthesia: An Exploration Of Synesthesia And Its Relation To Musical Perception,
2023
University of the Pacific
Music & Synesthesia: An Exploration Of Synesthesia And Its Relation To Musical Perception, Raquel S. Johnson
Pacific Undergraduate Research and Creativity Conference (PURCC)
This research investigates synesthesia and its impact on musical perception. Synesthesia is the multimodal sensory phenomenon in which the stimulation of one sensory modality generates the experience of a second, otherwise unrelated sense. Discussed topics include: a description of synesthesia and its neurophysiological and perceptual characteristics, the historical conceptualization and documentation of synesthesia beginning with the ancient Greeks, and present-day scientific inquiry. This research explores three varying types of auditory synesthesia - chromesthesia (sound-to-color synesthesia), auditory-tactile synesthesia, and sound-gustatory/sound-olfactory synesthesia - and their multimodal sensory characteristics in relation to music. Prominent neurophysiological hypotheses regarding the existence of synesthesia are examined, …
