Texas State University
University of Pennsylvania
CUNY College of Staten Island
Iowa State University
University of Nebraska-Lincoln
MosquitoMate, Inc.
Saint Louis University School of Law
New York University Winthrop Hospital, New York, USA.
Infectious Diseases Epidemiology, Molecular Virology and Special Pathogens Research, Department of Microbiology, Adekunle Ajasin University, PMB 001, Akungba Akoko, Ondo state, Nigeria.
Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium,
2023
West Virginia University
Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor
Graduate Theses, Dissertations, and Problem Reports
The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge ...
Evaluating The Practical Identifiability Of A Malaria Model To Assess Conversion To Transmissible Stages,
2022
Virginia Polytechnic Institute and State University
Evaluating The Practical Identifiability Of A Malaria Model To Assess Conversion To Transmissible Stages, Anthony Raymond Krueger, Damie Pak, Megan Greischar, Lauren Childs
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematical Model Of Immune-Inflammatory Response In Covid-19 Patients,
2022
Virginia Polytechnic Institute and State University
Mathematical Model Of Immune-Inflammatory Response In Covid-19 Patients, Quiyana M. Murphy
Biology and Medicine Through Mathematics Conference
No abstract provided.
Contributions Of Vibrational Spectroscopy To Virology: A Review,
2022
Technological University Dublin
Contributions Of Vibrational Spectroscopy To Virology: A Review, Iqra Chaudhary, Naomi Jackson, Denise Denning, Luke O'Neill, Hugh Byrne
Articles
Vibrational spectroscopic techniques, both infrared absorption and Raman scattering, are high precision, label free analytical techniques which have found applications in fields as diverse as analytical chemistry, pharmacology, forensics and archeometrics and, in recent times, have attracted increasing attention for biomedical applications. As analytical techniques, they have been applied to the characterisation of viruses as early as the 1970s, and, in the context of the coronavirus disease 2019 (COVID-19) pandemic, have been explored in response to the World Health Organisation as novel methodologies to aid in the global efforts to implement and improve rapid screening of viral infection. This review ...
Evaluation Of The Humoral/Fc-Mediated Immune Responses To An Adenovirus-26 Viral Vector/Gp140 Subunit Combined Vaccine Regimen As A Prophylactic Hiv-1,
2022
Cedarville University
Evaluation Of The Humoral/Fc-Mediated Immune Responses To An Adenovirus-26 Viral Vector/Gp140 Subunit Combined Vaccine Regimen As A Prophylactic Hiv-1, Nathan E. Adam
Channels: Where Disciplines Meet
Background and Introduction: HIV is one of the most problematic pandemics to date, currently infecting upwards of 38 million people worldwide (“The Global HIV/AIDS Epidemic,” 2020). Although infection and mortality rates have generally decreased, current prophylactic (preventive) measures against HIV-1 acquisition have shown major weaknesses that could be remedied with a vaccine (Pitisuttuthum & Marovich, 2020). Manufacturing an effective, prophylactic HIV-1 vaccine, however, is not without challenges - namely design/selection of vaccine-delivered immunogens (antigens) and elicitation of proper immune responses to HIV-1 antigens (Ng’uni et al., 2020). Fortunately, despite past, unsuccessful research, studies within the past 10-15 years have begun to elucidate immune correlates of protection against HIV-1 acquisition, specifically IgG1/IgG3 antibody (Ab) production, as well as non-neutralizing, Fc-Mediated effector functions (Rerks-Ngarm et al., 2009). Excitingly, studies released in the last 3 years, which use Adenovirus serotype-26 (Ad26) vector (Custers et al., 2020) show promising signs that an effective HIV-1 vaccine could become a reality (Baden et al., 2020; Barouch et al., 2018). Thus, for this presentation, I hope to show that Johnson & Johnson’s two new Ad26-based vaccines (combined with booster vaccines) sufficiently elicit key immune correlates of protection to warrant an Ad26 vector-based regimen’s testing past Phase 1/2a clinical trials. Results ...
The Effects Of Climate Change On The Transmission Of Lyme Disease,
2022
College of Saint Benedict/Saint John's University
The Effects Of Climate Change On The Transmission Of Lyme Disease, Schuyler Hedican, Katherine Kistler, Iveth Martinez Granados
Celebrating Scholarship and Creativity Day
Lyme disease currently affects approximately 300,000 people annually in the United States, but climate change threatens to increase this number. Rising temperatures, humidity, and levels of rainfall are impacting the relationship and interactions between the bacterium that causes Lyme disease (Borrelia burgdorferi), its vectors, and associated hosts. Climate change models predict a northward expansion of these disease-carrying vectors and hosts into new territories in North America, as formerly unsuitable territories become more hospitable, most notably in Canada. Human exposure to the bacteria through the bite of an infected tick can lead to the characteristic symptoms of Lyme disease, such ...
Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens,
2022
University of Arkansas, Fayetteville
Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian Gilbert
Animal Science Undergraduate Honors Theses
Lipoteichoic acid (LTA) is component of the cell wall of Gram-positive bacteria that stimulates inflammation during bacterial infection. However, few studies have investigated the in vivo immune response to LTA, and none of the in vivo studies done have been performed in birds. For this project, the pulp (a skin-derivative) of growing feathers (GFs) of chickens were used as a test site to investigate the in vivo effects of intradermally injected LTA. In Study 1, the pulp of 12 GFs of 11-week-old Light-brown Leghorn (LBL) males were injected with 10 μL of differing concentrations of LTA (0.1, 1.0 ...
Structural Formation And Functionality Of The Spoiie Protein In Clostridium Difficile,
2022
University of Arkansas, Fayetteville
Structural Formation And Functionality Of The Spoiie Protein In Clostridium Difficile, Rachel Siebenmorgen
Biological Sciences Undergraduate Honors Theses
My research efforts were directed toward the structure and functionality of a protein, designated SpoIIE [11], which previously has been shown to regulate C. difficile peptide utilization in addition to sporulation and toxin release. The SpoIIE protein is found in all spore-forming gram-positive bacteria and is a crucial component in activation of transcription factors and septum formation thus affecting the regulation and timing of spore development [11,12]. A truncated form of the SpoIIE protein named SpoIIE∆TM was used in an effort to determine the structure of an important but uncharacterized linker domain of the protein. If the structure ...
Spike Protein Structural Dynamics Of Sars-Cov-2 Coronaviruses Studied Using Molecular Dynamics,
2022
University of Arkansas, Fayetteville
Spike Protein Structural Dynamics Of Sars-Cov-2 Coronaviruses Studied Using Molecular Dynamics, William Strickland
Biological Sciences Undergraduate Honors Theses
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has overwhelmingly impacted the global population, accounting for millions of confirmed infections and deaths over the last year. The virus’s influence on the health and safety of individuals, the economy, and daily life has been disruptive and devastating. While SARS-CoV-2 and SARS-CoV-1, two closely related members of the SARS coronaviruses, have shown the ability to cross the species barrier and infect humans, SARS-CoV-2 has predominantly been the virus responsible for the number of infections presently known. SARS-CoV-2 has also proven to be volatile, as many variants ...
Native And Non-Native Ant Impacts On Soil Microbes,
2022
State University of New York College at Buffalo - Buffalo State College
Native And Non-Native Ant Impacts On Soil Microbes, Hannah A. Stewart
Biology Theses
Organisms produce chemical weapons for defense, but target organisms can develop resistance. In their introduced range, non-native species may bring “novel weapons” against which native organisms have not co-evolved resistance. The invasive European fire ant (Myrmica rubra) may have brought antimicrobial secretions to the Northeastern United States that are novel weapons against native fungal and bacterial soil organisms. I hypothesized that M. rubra would better inhibit seed pathogens resulting in greater emergence of native myrmecochorous Viola sororia seeds and, as a side effect, more strongly inhibit arbuscular mycorrhizal fungi than a native seed dispersing ant (Aphaenogaster picea). I also expected ...
Covid Susceptibility And Severity Correlation With The Ace2 Gene,
2022
University of Southern Maine
Covid Susceptibility And Severity Correlation With The Ace2 Gene, Natalie Taylor
Thinking Matters Symposium
A wide spectrum of susceptibility and severity of infection has been observed among COVID-19 patients. While some individuals remain unaffected by the Sars-Cov-2 virus, others have contracted the virus multiple times with varying levels of severity. This poster reviews some of the research demonstrating a link between the susceptibility of the Sars-Cov- 2 virus and the severity of infection, and a specific gene called ACE2. The ACE2 gene encodes an angiotensin-converting enzyme that acts as a functional receptor for the spike glycoprotein receptor binding domain of the coronavirus and severe acute respiratory syndrome coronaviruses. ACE2 presents numerous amino acid variants ...
Genomic Analysis Of Metabolic Differences Found In Clostridium Perfringens That Cause Necrotic Enteritis In Poultry,
2022
University of Nebraska-Lincoln
Genomic Analysis Of Metabolic Differences Found In Clostridium Perfringens That Cause Necrotic Enteritis In Poultry, Connor Aylor
Dissertations & Theses in Veterinary and Biomedical Science
Clostridium perfringens is a common member of gut microbiota in healthy animals, but can also be an important pathogen in human and veterinary medicine. It produces several protein toxins that contribute to both histotoxic and enteric diseases in animals. Necrotic enteritis in poultry has been associated with the NetB toxin of C. perfringens; however, this toxin alone is insufficient to cause disease in infected chickens. While considerable research has focused on the presence of toxins and virulence factors, little has been done to assess the function of metabolic factors on the ability of the bacteria to cause disease. In this ...
Adaptive Coping For Covid-Related Stress,
2022
Stephen F Austin State University
Adaptive Coping For Covid-Related Stress, Sandra Maloy
Undergraduate Research Conference
The restrictions placed on society by the COVID- 19 pandemic for the purpose of limiting spread of the disease appear to have produced a different set of potential chronic health issues. Through lockdown and social distancing measures the general public lost access to key elements of daily life. The literature and qualitative interview data primarily support a negative association between participation in spiritual and physical activity and COVID-19 related stress. These findings are not surprising based on previous research investigating coping and other chronic stressors.
Investigating Alternative Induction Of The S. Aureus 80a Prophage,
2022
University of Lynchburg
Investigating Alternative Induction Of The S. Aureus 80a Prophage, Jody Caretti
Student Scholar Showcase
Widespread antibiotic resistance has quickly become one of the most concerning crises affecting modern medicine, especially in cases of Staphylococcal infections, which have become resistant to all ��-lactam antibiotics. As a result, research into alternative forms of treatment for bacterial infections is a top priority. Bacteriophage therapy is a popular candidate for replacing antibiotics, due to the way the viruses interact with the bacteria. The 80�� prophage integrates its DNA into Staphylococcus aureus strain 10616 via the lysogenic cycle, and replicates with the bacterial cell. When stressed, the bacteria stop replicating and the prophage stimulates the lytic cycle, activating transcription ...
Feasibility Of Tubulin As A Control For Gene Expression Following Transfection In Mouse Monocyte/Macrophage-Like Cells,
2022
St. Mary's University
Feasibility Of Tubulin As A Control For Gene Expression Following Transfection In Mouse Monocyte/Macrophage-Like Cells, Ankita Chabra
St. Mary's University Honors Theses and Projects
Transfection, which is the ability to modify host cells’ genetic content, has broad application in studying normal cellular processes, molecular mechanism of disease and gene therapy. There are several transfection techniques, and all require either a control or a reference gene. Commonly used controls for transfection experiments are housekeeping genes, which maintain expression for a given cell/tissue, experimental conditions, and treatment. However, recent research has uncovered that expression levels of housekeeping genes may vary depending on the gene, cell type and experimental conditions. A growing body of evidence demonstrates that housekeeping genes are inadequate internal standards for measuring gene ...
Understanding The Natural History Of Juvenile Amblyomma Maculatum In Southeastern Virginia,
2022
Old Dominion University
Understanding The Natural History Of Juvenile Amblyomma Maculatum In Southeastern Virginia, Christina Espada, Holly Gaff
College of Sciences Posters
Amblyomma maculatum, the Gulf Coast tick, is a species of increasing public health concern. Adult A. maculatum is a known vector of several pathogens including Rickettsia parkeri, the causative agent of Rickettsia parkeri rickettsiosis. Amblyomma maculatum has expanded northward from its historic range along the Gulf Coast, with populations reportedly establishing in southeastern Virginia in 2010. Recently established populations of A. maculatum tend to have higher R. parkeri infection prevalence compared to longer established populations. This pattern holds for all populations found so far in southeastern Virginia, with a prevalence of R. parkeri in about 60% of A. maculatum compared ...
Sars-Cov-2 Reveals That Chimeric Agents Are The Bioweapons Of The Future,
2022
Liberty University
Sars-Cov-2 Reveals That Chimeric Agents Are The Bioweapons Of The Future, Rachel Craig
Senior Honors Theses
Bioweapons programs have existed since their development during the Cold War. These biowarfare programs initially utilized naturally occurring pathogens capable of infecting crops, livestock populations, and human populations. Anthrax is a widely exploited bioagent responsible for attacks ranging from the Germans’ deployment in World War I to the mailing of anthrax through the postal service in attempts on U.S. senators’ lives. With the development of genetic manipulations, the Soviet Union began modifying anthrax to resist detection and treatment. With the continued advancement of science and technology, a new bioagent has entered the scene – the man-made chimeric virus. Chimeric viruses ...
A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus,
2022
Brigham Young University - Provo
A Quantitative Analysis Of The Efficacy Of Various Essential Oils Against The Sars Cov-2 Virus, Elizabeth Wagstaff, Chandrelyn Kraczek, Jack Brandon Lopez
Annual Research Symposium
A poster presentation and abstract for the Roseman Symposium. The project focuses on testing 3 essential oil blends and two disinfectants containing an essential oil blend against SARS CoV-2 in response to the COVID-19 pandemic. The project procedure involves plaque assays, disinfection, and neutralization techniques.
Effects Of Alcohol On The Inflammatory Response During Toxoplasma Gondii Infection: Literature Review,
2022
Roseman University of Health Sciences
Effects Of Alcohol On The Inflammatory Response During Toxoplasma Gondii Infection: Literature Review, Amani Sastry
Annual Research Symposium
No abstract provided.
Meta-Analysis Of Transcriptomic Datasets For The Investigation Of Differential Expression In Hantavirus-Infected Human Tissue,
2022
Roseman University of Health Sciences
Meta-Analysis Of Transcriptomic Datasets For The Investigation Of Differential Expression In Hantavirus-Infected Human Tissue, John Krapohl
Annual Research Symposium
No abstract provided.
