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Articles 991 - 1020 of 4871
Full-Text Articles in Medicine and Health Sciences
Decrease Of Left Ventricular Ejection Fraction In Severe Illness Patients Due To Covid-19may Improve As The Disease Resolves, Aykut Demi̇rkiran, Lütfi̇ Çağatay Onar, Mustafa Doğan
Decrease Of Left Ventricular Ejection Fraction In Severe Illness Patients Due To Covid-19may Improve As The Disease Resolves, Aykut Demi̇rkiran, Lütfi̇ Çağatay Onar, Mustafa Doğan
Turkish Journal of Medical Sciences
Background/aim: Increase in publications supporting myocardial involvement in the COVID-19 disease has led to need to gain insight into the the global burden of heart failure after pandemic. We examined the course of myocardial systolic function in patients without elevated troponin levels. Materials and methods: We performed a prospective study. Patients with high troponin levels were excluded from the study in order to definitively exclude complications known to cause permanent left ventricular systolic dysfunction, such as acute coronary syndromes. Two echocardiographic examinations were performed. The first evaluation was performed within the days of hospitalization, if possible, on the day when …
Rituximab For The Treatment Of Idiopathic Membranous Nephropathy With Nephroticsyndrome: A Systematic Review And Meta-Analysis, Lu You, Peiyi Ye, Guangqing Xiao, Jiabao Liang, Yaozhong Kong
Rituximab For The Treatment Of Idiopathic Membranous Nephropathy With Nephroticsyndrome: A Systematic Review And Meta-Analysis, Lu You, Peiyi Ye, Guangqing Xiao, Jiabao Liang, Yaozhong Kong
Turkish Journal of Medical Sciences
Background/aim: This meta-analysis comprehensively investigated the efficacy and safety of rituximab (RTX) in patients with idiopathic membranous nephropathy (IMN). Materials and methods: We searched the MEDLINE, EMBASE and Cochrane Registry of Controlled Trials databases from January 2000 to January 2020. Studies evaluating the efficacy and safety of RTX in the treatment of IMN with nephrotic syndrome (NS) were included. Results: Nine studies (total of 357 patients) were included in the meta-analysis. The pooled complete response and overall response (OR) rates at 12 months were 13.2% [95% confidence interval (CI), 0.09-0.18] and 60% (95% CI, 0.48-0.72), and those at 24 months …
Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert
Influenza And Pneumococcus Vaccination Rates In Pediatric Dialysis Patients Ineurope: Recommendations Vs Realitya European Pediatric Dialysis Working Group And European Society For Pediatricnephrology Dialysis Working Group Study, Yeşi̇m Özdemi̇r Ati̇kel, Sevcan Azi̇me Bakkaloğlu Ezgü, Fabio Paglialonga, Constantinos J. Stefanidis, Varvara Askiti, Enrico Vidal, Gema Ariceta, Engi̇n Melek, Enrico Verrina, Nikoleta Printza, Karel Vondrak, Aleksandra Zurowska, Ilona Zagozdzon, Mesi̇ha Eki̇m, Eli̇f Nursel Özmert
Turkish Journal of Medical Sciences
Background/aim: Children on dialysis are under increased risk of influenza and invasive pneumococcal disease. Although vaccination against these microorganisms are recommended in dialysis patients and despite the fact that these vaccines can reduce disease burden and rates of hospitalization due to infection, vaccination rates are below expected and desired. We aimed to evaluate influenza and pneumococcal vaccination and infection rates in European pediatric dialysis centers. Materials and methods: In 16 centers from 11 countries, 357 pediatric dialysis patients were evaluated retrospectively during 1 year of observation period between 01.01.2014 and 01.01.2015. Results: In all centers, vaccination policy included immunization of …
Surgical Outcome Of Laminoplasty For Cervical Spondylotic Myelopathy: A Singleinstitution Experience, Mehmet Erhan Türkoğlu, Ahmet Gülmez, Çağri Elbi̇r, Ömer Selçuk Şahi̇n, Şahi̇n Hanali̇oğlu, Samet Di̇nç, Çağhan Tönge, Mehmet Kalan
Surgical Outcome Of Laminoplasty For Cervical Spondylotic Myelopathy: A Singleinstitution Experience, Mehmet Erhan Türkoğlu, Ahmet Gülmez, Çağri Elbi̇r, Ömer Selçuk Şahi̇n, Şahi̇n Hanali̇oğlu, Samet Di̇nç, Çağhan Tönge, Mehmet Kalan
Turkish Journal of Medical Sciences
Background/aim: Cervical spondylotic myelopathy (CSM) develops as a result of compression of the spinal cord in the cervical region. Early diagnosis and surgical treatment can limit the progression of symptoms. Various surgical approaches and strategies have been described in the literature. This study aims to evaluate the clinical and radiological results of open-door laminoplasty for the treatment of CSM. Materials and methods: In this study, we retrospectively analyzed the patients who underwent expansive open-door laminoplasty secured with titanium miniplates. Thirty-four patients with CSM who were followed up postoperatively for more than 12 months were included in the study. The modified …
Effect Of Hyperparathyroidism On Coagulation: A Global Assessment By Modifiedrotation Thromboelastogram (Rotem), Göknur Yorulmaz, Ahmet Toygar Kalkan, Aysen Akalin, Eli̇f Sevi̇l Alagüney, Eren Gündüz, Bartu Badak, Betül Aydin Buyruk, Medi̇ne Nur Kebapçi, Fatma Belgi̇n Efe, Muzaffer Bi̇lgi̇n, Olga Meltem Akay
Effect Of Hyperparathyroidism On Coagulation: A Global Assessment By Modifiedrotation Thromboelastogram (Rotem), Göknur Yorulmaz, Ahmet Toygar Kalkan, Aysen Akalin, Eli̇f Sevi̇l Alagüney, Eren Gündüz, Bartu Badak, Betül Aydin Buyruk, Medi̇ne Nur Kebapçi, Fatma Belgi̇n Efe, Muzaffer Bi̇lgi̇n, Olga Meltem Akay
Turkish Journal of Medical Sciences
Background/aim: Hyperparathyroidism is an endocrine disorder characterized by hypercalcemia. Because of calcium?s effects on parathyroid glands, bone, intestines, and kidneys, it has an important place in homeostasis. The results of studies regarding hyperparathyroidism hemostasis are conflicting. Thromboelastography helps to evaluate all steps of hemostatic system. Our aim in this study was to investigate the possible role of hemostatic mechanisms in the development of thrombosis in hyperparathyroid patients with the modified rotation thromboelastogram (ROTEM). Materials and methods: Twenty-two patients with primary hyperparathyroidism (PHPT) and 20 healthy controls were involved. This study was conducted in Eskisehir Osmangazi University Faculty of Medicine, Endocrinology …
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Turkish Journal of Medical Sciences
Background/aim: While several different scoring systems aim to determine the clinical outcomes for patients with pneumonia, there is limited emphasis on the platelet count. This study investigated the relationships between thrombocyte count and 30-day mortality and complicated clinical course of patients with pneumonia. Materials and methods: This prospective cross-sectional study enrolled patients over 18 years old with a diagnosis of pneumonia in the emergency department for six months. The primary outcome was to establish the relationship between platelet count, mortality, complicated clinical course, and initial vital parameters on admission. The secondary outcome was comparing the platelet count with mortality and …
Comparison Of Usg-Guided Or Landmark Approach Fascia Iliaca Compartment Blockfor Positioning In Elderly Hip Fracture Patients With Spinal Anesthesia: A Randomizedcontrolled Observational Study, Tuna Ertürk, İbrahi̇m Gündoğmuş, Temel Güner, Cengi̇z Yildirim, Ayşin Ersoy
Comparison Of Usg-Guided Or Landmark Approach Fascia Iliaca Compartment Blockfor Positioning In Elderly Hip Fracture Patients With Spinal Anesthesia: A Randomizedcontrolled Observational Study, Tuna Ertürk, İbrahi̇m Gündoğmuş, Temel Güner, Cengi̇z Yildirim, Ayşin Ersoy
Turkish Journal of Medical Sciences
Background/aim: Currently, the elderly population in the world is rapidly increasing due to technological developments and convenient access to health services. Due to comorbidities in elderly patients, hip fractures are frequently observed after exposure to environmental trauma. To reduce pain during positioning in spinal anesthesia, fascia iliaca compartment block (FICB) can be applied easily and reliably. In our study, we aimed to compare the analgesic effects and duration of fascia iliaca compartment blocks performed with USG guidance or the landmark approach methods for relieving spinal anesthesia position pain. Materials and methods: Our study included 100 patients undergoing operations due to …
Diagnostic Performance Of Shear Wave Elastography And Diffusion-Weighted Magneticresonance Imaging In Cervical Lymph Nodes: A Comparative Study, Veli̇ Süha Öztürk, Ersen Erteki̇n
Diagnostic Performance Of Shear Wave Elastography And Diffusion-Weighted Magneticresonance Imaging In Cervical Lymph Nodes: A Comparative Study, Veli̇ Süha Öztürk, Ersen Erteki̇n
Turkish Journal of Medical Sciences
Background/aim: To investigate the potential diagnostic value of point shear wave elastography (pSWE) and the contribution of concurrent diffusion weighted magnetic resonance imaging (DW-MRI) to diagnostic performance in patients with cervical lymphadenopathy. Materials and methods: This cross-sectional study included 116 cervical lymph nodes of 94 patients. All lymph nodes were evaluated before the treatment or histopathological sampling. Gray scale ultrasonographic features, elastographic stiffness and apparent diffusion coefficient (ADC) values were measured and recorded. Lymph nodes were divided into benign and malignant groups with histopathological findings. Results: Short axis measurement, axis ratio, hilum morphology, vascularization patterns, pSWE, and ADC values were …
Giant Hepatic Hemangioma Treatment With Transcatheter Arterial Embolisation Andtranscatheter Arterial Chemoembolisation; Comparative Results, Özhan Özgür, Hakki Ti̇mur Si̇ndel
Giant Hepatic Hemangioma Treatment With Transcatheter Arterial Embolisation Andtranscatheter Arterial Chemoembolisation; Comparative Results, Özhan Özgür, Hakki Ti̇mur Si̇ndel
Turkish Journal of Medical Sciences
Background/aim: Treatment of hepatic hemangiomas is a controversial topic, and traditional treatment is surgical excision. Transcatheter arterial embolisation (TAE) and transcatheter arterial chemoembolisation (TACE) have been reported as minimally invasive treatment methods. To the best of our knowledge, there are no studies comparing use of TACE and TAE for hepatic hemangioma treatment. The aim of the study is to compare symptom resolution, size reducing effects, and complications of TACE and TAE for the treatment of giant hepatic hemangiomas. Materials and methods: A total of 104 patients underwent TACE using bleomycin, and 108 patients underwent TAE. The patients were followed-up for …
Differentiation Of Benign And Malignant Superficial Soft Tissue Lesions Using Real-Timestrain Elastography, Gökçe Annaç, Murat Canyi̇ği̇t, Si̇nan Tan, Ersi̇n Akşam, Nuran Süngü, Hali̇l Arslan
Differentiation Of Benign And Malignant Superficial Soft Tissue Lesions Using Real-Timestrain Elastography, Gökçe Annaç, Murat Canyi̇ği̇t, Si̇nan Tan, Ersi̇n Akşam, Nuran Süngü, Hali̇l Arslan
Turkish Journal of Medical Sciences
Background/aim: To evaluate benign and malignant cutaneous-subcutaneous lesions using real-time strain elastography (RTSE) and to compare the findings with histopathologic results. Materials and methods: Over a period of 10 months, 72 patients (38 with benign and 34 with malignant cutaneous and subcutaneous lesions) were prospectively included in this study. Elasticity patterns and strain ratios were examined for each lesion. Lesions were evaluated in 4 groups as yellow-red (soft; pattern-1), green-yellow (moderate; pattern-2), blue-green (hard; pattern-3) and blue (hardest; pattern-4). The stiffness of the lesions was displayed with strain ratios by comparing of a nearby reference tissue. The recorded images were …
Distal Spread And Tumor Regression Patterns Following Preoperative Chemoradiotherapyin Rectal Cancer Patients, İlter Özer, Nesli̇han İnci̇ Zengi̇n, Haci Murat Çayci, Adem Yüksel, Tahsi̇n Dalgiç, Murat Ulaş, Erdal Bi̇rol Bostanci, Musa Akoğlu
Distal Spread And Tumor Regression Patterns Following Preoperative Chemoradiotherapyin Rectal Cancer Patients, İlter Özer, Nesli̇han İnci̇ Zengi̇n, Haci Murat Çayci, Adem Yüksel, Tahsi̇n Dalgiç, Murat Ulaş, Erdal Bi̇rol Bostanci, Musa Akoğlu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the regression pattern with the distal intramural spread (DIS) of rectum cancer after preoperative chemoradiation. Materials and methods: Specimens from 56 patients who underwent radical resection after preoperative chemoradiation for rectal cancer were examined. The regression pattern (total, fragmented) of the tumor was recorded. DIS status was evaluated by creating sections 0.2 to 0.3 cm thick. Results: A single macroscopic residual area was detected in all specimens. In 10 patients (17.8 %), pathologically complete responses were identified, and DIS was detected in 33 patients (58.9%). The average DIS distance was 0.56 ± 0.3 cm …
Electrocardiography Clues In Assessment Of Patients With Premature Ventricularcontractions, Ahmet Akdi̇, Bahar Teki̇n Tak, Eli̇f Hande Özcan Çeti̇n, Mehmet Serkan Çeti̇n, Çağri Yayla
Electrocardiography Clues In Assessment Of Patients With Premature Ventricularcontractions, Ahmet Akdi̇, Bahar Teki̇n Tak, Eli̇f Hande Özcan Çeti̇n, Mehmet Serkan Çeti̇n, Çağri Yayla
Turkish Journal of Medical Sciences
Background/aim: Some electrocardiography (ECG) parameters such as Tp-e interval, Tp-e / QT ratio, fragmented QRS (fQRS), and heart rate variability (HRV) are related to cardiovascular mortality and morbidity. We aim to investigate the relation between premature ventricular contraction burden and these parameters on 24-h ECG recording. Materials and methods: The study is a retrospective investigation of the 24-h Holter ECG and echocardiography of 199 patients who underwent the procedures due to complaints of palpitation. A frequency of < 10% PVCs / 24 h was classified as seldom group (98 patients), while > 10% PVCs / 24 h was designated as frequent group (101 patients). Results: Tp-e interval was significantly longer (62 [54-78] vs 75 [60-84], …
Frequency Of Peripheral Blood Eosinophilia And Obstructive Airway Disease In Sarcoidosis, Bi̇lal Rabahoğlu, Fatma Sema Oymak, Burcu Baran Ketenci̇oğlu, Nuri̇ Tutar, İnci̇ Gülmez, İnsu Yilmaz
Frequency Of Peripheral Blood Eosinophilia And Obstructive Airway Disease In Sarcoidosis, Bi̇lal Rabahoğlu, Fatma Sema Oymak, Burcu Baran Ketenci̇oğlu, Nuri̇ Tutar, İnci̇ Gülmez, İnsu Yilmaz
Turkish Journal of Medical Sciences
Background/aim: There is limited information about peripheral blood eosinophilia (PBE) and airway obstruction in sarcoidosis. Since pulmonary sarcoidosis affects the airways, it is often confused with asthma. The aims of the study are to investigate airway obstruction and PBE in sarcoidosis patients and to examine the similarity of clinical presentation with asthma. Materials and methods: The patients matching the ATS/ERS/WASOG diagnosis criteria and were between 18 and 80 years of age were included consecutively between 2018 and 2020. Other diseases causing granulomas were excluded. Results: A total of 84 patients were included of which 26 (31%) had a PBE level …
Investigation Of The Correlation Between Mood Disorder Symptoms And Disease Activityand Functional Status In Rheumatoid Arthritis Patients, Meli̇h Pamukcu, Tuğba İzci̇ Duran, Hasan Ulusoy, Kürşat Altinbaş
Investigation Of The Correlation Between Mood Disorder Symptoms And Disease Activityand Functional Status In Rheumatoid Arthritis Patients, Meli̇h Pamukcu, Tuğba İzci̇ Duran, Hasan Ulusoy, Kürşat Altinbaş
Turkish Journal of Medical Sciences
Background/aim: To investigate the correlation between depressive-anxiety symptoms, mixed features, disease activity, and functional status in patients with rheumatoid arthritis (RA) in the light of the shared underlying etiology in both disorders. Materials and methods: The study included 556 patients with RA. RA disease activity was measured using the Disease Activity Score 28-joint count C reactive protein (DAS28-CRP), and the patients were evaluated by a Health Assessment Questionnaire (HAQ). The Hospital Anxiety and Depression Scale (HADS), Mood Disorder Questionnaire (MDQ), and Modified Hypomania Checklist (mHCL) were used to evaluate the mixed depression and bipolarity status of the patients. Results: Of …
The Potential Role Of Human Hiv-1 Tat-Interactive Protein 2levels In The Pathogenesis Of Contact Dermatitis, Mahmut Sami̇ Meti̇n, Handan Bi̇len, Ömer Faruk Elmas, Necmetti̇n Akdeni̇z
The Potential Role Of Human Hiv-1 Tat-Interactive Protein 2levels In The Pathogenesis Of Contact Dermatitis, Mahmut Sami̇ Meti̇n, Handan Bi̇len, Ömer Faruk Elmas, Necmetti̇n Akdeni̇z
Turkish Journal of Medical Sciences
Background/aim: Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is a gene that is extensively expressed in human tissues as well as in tumor tissues. This study aimed to explore the potential role of HTATIP2/TIP30 in contact dermatitis (CD), which is one of the most common inflammatory cutaneous conditions. Materials and methods: This cross-sectional study involved adult patients with acute contact dermatitis who were admitted to the outpatient dermatology clinic of a tertiary hospital and healthy adult volunteers without any cutaneous or systemic diseases. The blood concentration of HTATIP2/TIP30 was measured using ELISA kits. Results: The research sample consisted of 31 …
Three-Dimensional Assessment Of Pharyngeal Airway In Individuals With Myotonicdystrophy Type 1, Burcu Evli̇ce, Ayşe Fi̇li̇z Koç, Hazal Duyan, Damla Soydan Çabuk
Three-Dimensional Assessment Of Pharyngeal Airway In Individuals With Myotonicdystrophy Type 1, Burcu Evli̇ce, Ayşe Fi̇li̇z Koç, Hazal Duyan, Damla Soydan Çabuk
Turkish Journal of Medical Sciences
Background/aim: The objectives of this study were to assess pharyngeal airway volume (PAV) in patients with myotonic dystrophy type 1 (DM1) by cone-beam computerized tomography (CBCT) and to evaluate the impact of diaphragm thickness and pulmonary function tests on PAV. Materials and methods: Thirty DM1 patients (10 female and 20 male; mean age 42.40 ± 12.07) were included in the study. Age and sex-matched thirty patients were participated as control group. In DM1 group pulmonary function tests (PFT) were performed. Independent t-test was used to compare PAV values of patients with DM1 and control group. The Mann-Whitney U test was …
Serum Chitotriosidase And Ykl-40 In Acute Pancreatitis: Reliability As Prognostic Markerfor Disease Severity And Correlation With Inflammatory Markers, Ece Ünal Çeti̇n, Fati̇h Kamiş, Adi̇l Uğur Çeti̇n, Yavuz Beyazi̇t, Murat Keki̇lli̇
Serum Chitotriosidase And Ykl-40 In Acute Pancreatitis: Reliability As Prognostic Markerfor Disease Severity And Correlation With Inflammatory Markers, Ece Ünal Çeti̇n, Fati̇h Kamiş, Adi̇l Uğur Çeti̇n, Yavuz Beyazi̇t, Murat Keki̇lli̇
Turkish Journal of Medical Sciences
Background/aim: Chitotriosidase and YKL-40, also called chitinase 3-like protein 1, are homologs of family 18 glycosyl hydrolases, secreted by human macrophages and granulocytes under inflammatory conditions. Although increased levels of chitotriosidase and YKL-40 are linked with several inflammatory diseases, the physiological utility of these two enzymes is still not fully characterized. This study aims to analyse the serum YKL-40 and chitotriosidase levels of acute pancreatitis patients to assess whether their activity correlates with acute pancreatitis and its severity. Materials and methods: Chitotriosidase and YKL-40 levels, along with routine laboratory parameters, were determined from the serum samples of 41 acute pancreatitis …
Investigation Of The Effects Of Angiotensin Converting Enzyme Inhibitors And Angiotensinreceptor Blockers On Anemia In Patients With Normal Or Mildly Low Glomerular Filtrationrate, Betül Ergün, Aysun Aybal Kutlugün, Mustafa Çağri Ergün, Gali̇p Aktürk, Esi̇n Beyan
Investigation Of The Effects Of Angiotensin Converting Enzyme Inhibitors And Angiotensinreceptor Blockers On Anemia In Patients With Normal Or Mildly Low Glomerular Filtrationrate, Betül Ergün, Aysun Aybal Kutlugün, Mustafa Çağri Ergün, Gali̇p Aktürk, Esi̇n Beyan
Turkish Journal of Medical Sciences
Background/aim: The relationship between the activation of the renin-angiotensin system and the increase in erythropoiesis has been shown in many studies. In addition, the use of angiotensin converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARB) has been reported to reduce hemoglobin levels in various patient groups at risk for secondary erythrocytosis/polycythemia. The aim of our study is to investigate whether there is a change in hemoglobin levels after starting ACEIs or ARBs in patients who have not used them before. Materials and methods: Three hundred and fifty-one patients who were started on renin angiotensin aldosterone system (RAAS) blockers were evaluated …
A Newly Described Imaging Finding For Idiopathic Normal Pressure Hydrocephalus: Canhummingbird Sign Contribute To The Diagnosis?, Başak Atalay, Umut Perçem Orhan Söylemez, Hüseyi̇n Yildiz
A Newly Described Imaging Finding For Idiopathic Normal Pressure Hydrocephalus: Canhummingbird Sign Contribute To The Diagnosis?, Başak Atalay, Umut Perçem Orhan Söylemez, Hüseyi̇n Yildiz
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to evaluate whether morphological changes in the mesencephalon, which were previously described as a diagnostic tool for progressive supranuclear palsy, could be associated also with idiopathic normal pressure hydrocephalus. Materials and methods: Consecutive 52 patients with a possible diagnosis of idiopathic normal pressure hydrocephalus (32 female, mean age 73.6 years) and 40 controls (23 female, mean age 72.7 years) with similar demographic characteristics were included the study. The morphologic changes in mesencephalon, hummingbird sign, and the vascular compression to mesencephalon were noted. Besides, three independent observers evaluated the imaging parameters for idiopathic normal pressure …
Calcitonin Levels In Washout Samples Vs. Cytology In The Detection Of Malignant Lymphnode Metastasis In Recurrent Medullary Thyroid Cancer, Asena Gökçay Canpolat, Mustafa Şahi̇n, Koray Ceyhan, Serpi̇l Sak, Özgür Demi̇r, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Demet Çorapçioğlu
Calcitonin Levels In Washout Samples Vs. Cytology In The Detection Of Malignant Lymphnode Metastasis In Recurrent Medullary Thyroid Cancer, Asena Gökçay Canpolat, Mustafa Şahi̇n, Koray Ceyhan, Serpi̇l Sak, Özgür Demi̇r, Rifat Emral, Murat Fai̇k Erdoğan, Sevi̇m Güllü, Demet Çorapçioğlu
Turkish Journal of Medical Sciences
Background/aim: Calcitonin level in fine-needle aspirate washout fluid (Ct-FNA) was extensively studied for thyroid nodules and lymph nodes (LN). However, the data was scarce for neck recurrences/metastases of medullary thyroid cancer (MTC). Thus, the diagnostic accuracy of Ct-FNA and cytology in the detection of neck LN metastases of recurrent MTC cases were assessed. Materials and methods: The database of MTC patients between 2010 and 2021 was retrospectively reviewed. A total of 32 patients with recurrent MTC and suspicious LN who underwent FNA and Ct measurement from washout samples were included in this study. Preoperative serum Ct (sCt), Ct-FNA, Ct-FNA/sCt ratio, …
Biliary Stents Are Forgotten More Frequently In Elderly Patients, Ali̇ Erkan Duman, Hasan Yilmaz, Sadetti̇n Hülagü
Biliary Stents Are Forgotten More Frequently In Elderly Patients, Ali̇ Erkan Duman, Hasan Yilmaz, Sadetti̇n Hülagü
Turkish Journal of Medical Sciences
Background/aim: Plastic biliary stents that remain in situ for more than 12 months, called forgotten biliary stents (FBSs), can cause complications such as cholangitis, stent migration, stent occlusion, and perforation. Materials and methods: The medical records of patients who underwent ERCP procedures from December 2016 to December 2020 were analysed retrospectively. Data on patient characteristics, indications for ERCP and stenting, stent types, stenting duration, complications, and causes of FBSs were obtained from the hospital's database. Results: A total of 48 cases with FBSs were analysed. The mean age (SD) of the patients was 71.23 years (±12.165), the male-to-female ratio was …
The Evaluation Of Breast Findings Detected Through Different Visualisation Techniques Inacromegaly Patients ? A Retrospective Study, Pinar Akhanli, Sema Hepşen, Beki̇r Uçan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal
The Evaluation Of Breast Findings Detected Through Different Visualisation Techniques Inacromegaly Patients ? A Retrospective Study, Pinar Akhanli, Sema Hepşen, Beki̇r Uçan, Hakan Düğer, Hayri̇ Bostan, Muhammed Kizilgül, Muhammed Erkam Sencar, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: It is known that the increased growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have mitogenic and antiapoptotic properties in breast cells in acromegaly. Our study aims to evaluate breast findings in patients with acromegaly by comparing them to the control group. Materials and methods: Sixty-one patients followed with acromegaly diagnosis and 180 healthy controls were included in our study. Demographic data, laboratory results, Breast Imaging-Reporting and Data System (BI-RADS) scores, and breast density evaluated via mammography, malign and benign breast lesions evaluated via mammography, breast ultrasonography (USG), and breast magnetic resonance imaging (MRI) of patients were compared to …
Evaluation Of Efficacy And Safety Of Pirfenidone 200 Mg Tablets In Patients With Idiopathicpulmonary Fibrosis In A Real-Life Setting, Necmi̇ye Funda Coşkun, Aykut Çi̇lli̇, İsmai̇l Hanta, Can Sevi̇nç, Ayşe Ödemi̇ş, Ahmet Ursavaş
Evaluation Of Efficacy And Safety Of Pirfenidone 200 Mg Tablets In Patients With Idiopathicpulmonary Fibrosis In A Real-Life Setting, Necmi̇ye Funda Coşkun, Aykut Çi̇lli̇, İsmai̇l Hanta, Can Sevi̇nç, Ayşe Ödemi̇ş, Ahmet Ursavaş
Turkish Journal of Medical Sciences
Background/aim: Phase III trials have demonstrated a significant efficacy and an acceptable safety for pirfenidone in patients having mild to moderate idiopathic pulmonary fibrosis (IPF). Real-life data on the use of pirfenidone 200 mg tablets are limited. This study aimed to investigate the efficacy and safety of pirfenidone 200 mg tablets for the treatment of IPF in a real-life setting. Materials and methods: A retrospective, multicenter study conducted in four university hospitals in Turkey between January 2017 and January 2019. Clinical records of patients diagnosed with mild to moderate IPF and receiving pirfenidone (200 mg tablets, total 2400 mg/day) were …
Comparison Of Different Neuromuscular Facilitation Techniques And Conventionalphysiotherapy In Knee Osteoarthritis, Ayşenur Gökşen, Fi̇li̇z Can, Seval Yilmaz, Feza Korkusuz
Comparison Of Different Neuromuscular Facilitation Techniques And Conventionalphysiotherapy In Knee Osteoarthritis, Ayşenur Gökşen, Fi̇li̇z Can, Seval Yilmaz, Feza Korkusuz
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to compare the effects of conventional physiotherapy and two different `proprioceptive neuromuscular facilitation' (PNF) techniques on knee muscle strength, knee muscular endurance, and proprioception in knee osteoarthritis (KOA). Materials and methods: The study included 35 patients between the ages of 47 and 62 who were diagnosed with stage 1-2 KOA. The patients were divided into three groups with block randomization method as Repeated Stretching Group (N = 12) With Repeated Stretching Technique, Combined Isotonic Contraction Group (N = 11) With Combined Isotonic Contractions (CIC) Technique, And Conventional Physiotherapy Group (n = 12). PNF was applied …
Protective Effects Of Anandamide Against Cisplatin-Induced Peripheral Neuropathy Inrats, Çi̇ğdem Çengelli̇ Ünel, Başak Ayaz, Şule Aydin, Emel Ulupinar, Orhan Özati̇k, Bi̇lgi̇n Kaygisiz, Engi̇n Yildirim, Kevser Erol
Protective Effects Of Anandamide Against Cisplatin-Induced Peripheral Neuropathy Inrats, Çi̇ğdem Çengelli̇ Ünel, Başak Ayaz, Şule Aydin, Emel Ulupinar, Orhan Özati̇k, Bi̇lgi̇n Kaygisiz, Engi̇n Yildirim, Kevser Erol
Turkish Journal of Medical Sciences
Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in vitro effects of AN in CIS neurotoxicity, and the contribution of nitric oxide (NO) in this effect. Materials and methods: This is an experimental animal study. Primary dorsal root ganglion (DRG) cultures were prepared from oneday-old rats for in vitro investigations. DRG cells were incubated with CIS (100-300 μM), and AN (10, 50, …
Neuropeptide-S Affects Cognitive Impairment And Depression-Like Behavior On Mptpinduced Experimental Mouse Model Of Parkinson?S Disease, Ayşe Özkan, Mehmet Bülbül, Nari̇n Deri̇n, Osman Si̇nen, Güven Akçay, Hande Parlak, Mutay Aydin Aslan, Aysel Ağar
Neuropeptide-S Affects Cognitive Impairment And Depression-Like Behavior On Mptpinduced Experimental Mouse Model Of Parkinson?S Disease, Ayşe Özkan, Mehmet Bülbül, Nari̇n Deri̇n, Osman Si̇nen, Güven Akçay, Hande Parlak, Mutay Aydin Aslan, Aysel Ağar
Turkish Journal of Medical Sciences
Background/aim: The present study proposes to investigate the effect of neuropeptide-S (NPS) on cognitive functions and depressionlike behavior of MPTP-induced experimental model of Parkinson's disease (PD). Materials and methods: Three-month-old C57BL/6 mice were randomly divided into three groups as; Control, Methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) and MPTP + NPS 0.1 nmol (received intraperitoneal injection of MPTP and intracerebroventricular injection of NPS, 0.1 nmol for seven days). The radial arm maze and pole tests were carried out, and the levels of tyrosine hydroxylase (TH) were determined using western blotting. A mass spectrometer was used to measure the levels of dopamine, glutamic acid, and glutamine. …
Trace Element & Vitamin Content Of Ankaferd Hemostat And Hepatoprotective Effect, Begüm Güneş, Nazi̇fe Yasemi̇n Ardiçoğlu Akişin, Mehmet Nejat Akar
Trace Element & Vitamin Content Of Ankaferd Hemostat And Hepatoprotective Effect, Begüm Güneş, Nazi̇fe Yasemi̇n Ardiçoğlu Akişin, Mehmet Nejat Akar
Turkish Journal of Medical Sciences
No abstract provided.
Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇
Risk Of Tuberculosis Is Increased In Behçet's Disease Compared To Other Rheumatologicaldisorders After Anti-Tnf∝ Treatments: A Case Series And Review Of The Literature, Ümmügülsüm Gazel, Derya Kocakaya, İrem Hi̇cret Topçu, Hakan Ömer Karataş, Murat Karabacak, Mehmet Pami̇r Atagündüz, Güzi̇de Nevsun İnanç, Fatma Ali̇baz Öner, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Background/aim: Tumor necrosis factor-alfa (TNF-a) antagonists are extensively utilized in the treatment of inflammatory rheumatic diseases and also shown to be effective in Behçet's disease (BD) patients with major organ involvement. In this study, we aimed to reevaluate the incidence of tuberculosis (TB) infection after anti-TNFa treatments and to reveal the risk of TB in BD. Methods: Data of patients who received anti-TNFa treatment between 2005 and 2018 were assessed retrospectively. Demographic features, TNF-a antagonist type/treatment time, tuberculosis skin test (TST) and QuantiFERON results, isoniazid prophylaxis status, and concomitant corticosteroid (CS) treatments were collected. Results: A total of 1277 (male/female …
How Important Is The Sphenoseptal Cell In Identifying The Skull Base?Recent Incidence And Demonstration Of Endoscopic Surgical Steps, Cem Saka, Bülent Öcal, Emel Çadalli Tatar, Gökhan Toptaş, Tuğçe Pütürgeli̇ Özer, Mehmet Hakan Korkmaz
How Important Is The Sphenoseptal Cell In Identifying The Skull Base?Recent Incidence And Demonstration Of Endoscopic Surgical Steps, Cem Saka, Bülent Öcal, Emel Çadalli Tatar, Gökhan Toptaş, Tuğçe Pütürgeli̇ Özer, Mehmet Hakan Korkmaz
Turkish Journal of Medical Sciences
Background/aim: Because of close relations to important anatomical structures such as cavernous sinus and optic nerve, sphenoid sinus variations must be well trained by the otolaryngologist who has an interest in endoscopic sinus surgery. Newly defined sphenoseptal cell (SSC) is one of those variations that may lead to insufficient endoscopic sinus surgery outcomes if not defined preoperatively with imaging studies. The present study aimed to present the main characteristics of this special type of nasal cell. Materials and methods: In this study, 610 paranasal sinus CT scans were analyzed and reviewed retrospectively between May 2018 and December 2019. Also, endoscopic …
Evaluation Of Extensively Drug-Resistant Gram-Negative Bacteremia Among Solid-Organtransplant Recipients: A Multicenter Study, Tuğba Yanik Yalçin, Özlem Azap, Adem Köse, Yaşar Bayindir, Eli̇f Muki̇me Saricaoğlu, Güle Çinar, Yeşi̇m Uygun Kizmaz, Ebru Kurşun, Hi̇kmet Eda Alişkan, Ayşe Yasemi̇n Tezer Tekçe, Oya Özlem Eren Kutsoylu, Tufan Egeli̇, Alpay Ari, Yurdagül Albayrak, Hati̇ce Çabadak
Evaluation Of Extensively Drug-Resistant Gram-Negative Bacteremia Among Solid-Organtransplant Recipients: A Multicenter Study, Tuğba Yanik Yalçin, Özlem Azap, Adem Köse, Yaşar Bayindir, Eli̇f Muki̇me Saricaoğlu, Güle Çinar, Yeşi̇m Uygun Kizmaz, Ebru Kurşun, Hi̇kmet Eda Alişkan, Ayşe Yasemi̇n Tezer Tekçe, Oya Özlem Eren Kutsoylu, Tufan Egeli̇, Alpay Ari, Yurdagül Albayrak, Hati̇ce Çabadak
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients' records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients …