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Articles 691 - 720 of 4871
Full-Text Articles in Medicine and Health Sciences
Prospective Analysis Of Intoxicated Patients Developing Shock And/Or Organ Failure, Faysal Teki̇n, Ayça Açikalin Akpinar, Ömer Taşkin, Ufuk Akday, Nezi̇hat Rana Di̇şel, Emre Karakoç
Prospective Analysis Of Intoxicated Patients Developing Shock And/Or Organ Failure, Faysal Teki̇n, Ayça Açikalin Akpinar, Ömer Taşkin, Ufuk Akday, Nezi̇hat Rana Di̇şel, Emre Karakoç
Turkish Journal of Medical Sciences
Background/aim: Data on intoxication patients with shock and acute organ failure is valuable for the prediction of the tailored scale prognosis of the patients in the emergency department. Materials and methods: Our study was designed prospectively as a cross-sectional and observational over the course of four years. The patients over 18 years of age were included and the epidemiological data related to development of shock and acute organ failure, the treatments, and the outcome were recorded. The organic phosphate severity score was also calculated for all patients. Results: A total of 89 patients with shock and/or acute organ failure 72 …
Identification Of Subclinical Iron Deficiency Using New Erythrocytes, Leukocytes, And Reticulocytes Parameters During Nonsevere Acute Infection In Pediatric Outpatients, Nazmi̇ Mutlu Karakaş, Serap Ki̇rki̇z Kayali, Zühre Kaya
Identification Of Subclinical Iron Deficiency Using New Erythrocytes, Leukocytes, And Reticulocytes Parameters During Nonsevere Acute Infection In Pediatric Outpatients, Nazmi̇ Mutlu Karakaş, Serap Ki̇rki̇z Kayali, Zühre Kaya
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate the diagnostic utility of new erythrocytes, leukocytes, and reticulocytes parameters for the identification of subclinical iron deficiency (ID) in children under 6 years with nonsevere acute infection in pediatric outpatients. Materials and methods: The study included 102 children with acute infections and 31 true ID. Traditional and new hematology parameters were measured in a Sysmex-XN® , along with C-reactive protein level, and iron parameters. Participants? ID were categorized as: the ferritin < 100 ng/mL, transferrin saturation < 20% was defined as ?subclinical or functional ID (FID) in Group 1?; ferritin < 30 ng/mL, transferrin saturation < 20%, as ?absolute-ID (AID)? in Group 2; ferritin < 12 ng/mL without anemia and infection, as ?true ID? in Group 3. Results: The frequencies of FID and AID among the 102 children with acute infection were 24% and 76%, respectively. Compared with the Group 2 patients, Group 1 had a significantly higher mean percentage of hypochromic erythrocytes (Hypo-He), and significantly lower levels of hemoglobin (Hb) and Hb content of reticulocytes (RET-He) (p < 0.05 for all). Compared with Group 2 and Group 3 patients, Group 1 had a significantly higher mean percentage of immature reticulocyte fraction (IRF) and immature granulocyte (IG) values (p < 0.05 for all). The RET-He, IRF%, Hypo-He%, and IG% cut-off values for predicting FID during infection were 27.0 pg, 10.6%, 2.5%, and 0.35% respectively. Conclusion: The RET-He, Hypo-He, IRF, and IG may be useful parameters for identifying subclinical ID in small children with nonsevere acute infection in pediatric outpatients.
Evaluation Of The Effect Of Hyperchloremia On The Prognosis And Mortality Of Medical Intensive Care Patients: A Single-Center Study, Habi̇p Yilmaz, Başak Çakir Güney
Evaluation Of The Effect Of Hyperchloremia On The Prognosis And Mortality Of Medical Intensive Care Patients: A Single-Center Study, Habi̇p Yilmaz, Başak Çakir Güney
Turkish Journal of Medical Sciences
Background/aim: While chloride (Cl) is the most abundant anion in the serum, it is unfortunately one of the most commonly disregarded laboratory test results routinely drawn upon admission into the medical intensive care unit (MICU). We aimed to investigate the relation between in-hospital mortality, different pathologies requiring admission to the MICU, serum Cl levels, and other biochemical tests in a tertiary center. Materials and methods: The prospective study included data from 373 patients admitted to the ICU of a tertiary care center between 2017 and 2019. Data of patients under 18, pregnant patients or patients who were in the MICU …
Copy Number Variations In Patients With Idiopathic Recurrent Pregnancy Loss: An Arraycgh Approach, Onur Yildiz, Fatma Silan, Taner Karakaya, Öztürk Özdemi̇r
Copy Number Variations In Patients With Idiopathic Recurrent Pregnancy Loss: An Arraycgh Approach, Onur Yildiz, Fatma Silan, Taner Karakaya, Öztürk Özdemi̇r
Turkish Journal of Medical Sciences
Background/aim: It is not always possible to determine the causative basis of pregnancy losses and even today it has been reported that 50% of cases with recurrent pregnancy loss (RPL) have no reason to be detected. In our study, it is aimed to reveal the copy number variations (CNVs) of the genes which presumably have a potential effect in individuals with RPL and contribute to subsequent functional studies in the follow-up. Materials and methods: We retrospectively evaluated the array-comparative genomic hybridization (aCGH) data of cytogenetically 64 normal individuals (21 couples, 11 unrelated women, and 11 unrelated men) who had applied …
Performance Of Indirect Immunofluorescence Test And Immunoblot Tests In The Evaluation Of Antinuclear And Antimitochondrial Antibodies, Ömer Öztürk, Selay Demi̇rci̇ Dos Santos Duarte, Hati̇ce Yasemi̇n Balaban, Hali̇s Şi̇mşek, Burçi̇n Şener
Performance Of Indirect Immunofluorescence Test And Immunoblot Tests In The Evaluation Of Antinuclear And Antimitochondrial Antibodies, Ömer Öztürk, Selay Demi̇rci̇ Dos Santos Duarte, Hati̇ce Yasemi̇n Balaban, Hali̇s Şi̇mşek, Burçi̇n Şener
Turkish Journal of Medical Sciences
Background/aim: Antinuclear antibodies (ANA) and antimitochondrial antibodies (AMA) have essential markers for the diagnosis of autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). These autoantibodies are detecting different laboratory methods. In this study, we studied the diagnostic performance of used methods in detecting ANA and AMA. Materials and methods: The autoantibody profiles of patients with AIH and PBC groups were analyzed with the indirect immunofluorescence test (IIF) and liver-specific antigens containing immunoblot test (IB). Results: There were 45 (87%) women in the study group and 8 (53%) women in the control group. The mean age of the patients was 50.5 …
The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle
The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle
Turkish Journal of Medical Sciences
Background/aim: Sjögren?s syndrome is a systemic, autoimmune disease and can affect many organs and systems. In this study, we aimed to evaluate the respiratory manifestations, and the association between interstitial lung disease (ILD) and disease activity in primary SS (pSS) patients. Materials and methods: The study design was retrospective cross-sectional, and 151 patients followed up with a diagnosis of pSS between 2004 and 2019 were included in the study. Demographic and clinical data, laboratory results, chest radiographs and thorax computed tomography (CT) results were obtained from patient files and hospital imaging system. Thorax CT was requested from all patients with …
Ultrasound-Guided Rhomboid Intercostal Block For Myofascial Pain Syndrome: A Prospective Clinical Study, Seli̇n Güven Köse, Hali̇l Ci̇han Köse, Serkan Tulgar, Ömer Taylan Akkaya
Ultrasound-Guided Rhomboid Intercostal Block For Myofascial Pain Syndrome: A Prospective Clinical Study, Seli̇n Güven Köse, Hali̇l Ci̇han Köse, Serkan Tulgar, Ömer Taylan Akkaya
Turkish Journal of Medical Sciences
Background/aim: Myofascial pain syndrome (MPS) is a common chronic pain syndrome that may affect quality of life, daily living activities, and psychological status. Ultrasound (US)-guided rhomboid intercostal block (RIB) is a recently defined plane block and used for chronic pain such as postmastectomy syndrome and MPS. Our aim was to evaluate the efficacy of US-guided RIB for the management of pain, quality of life, physical disability, and patient satisfaction in MPS. Materials and methods: In this prospective study, between February and March 2021, a total of 30 patients who applied with the diagnosis of MPS, were included. The patients received …
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman
Turkish Journal of Medical Sciences
Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods: This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of …
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Enhancing Effect Of Nicotine On Electrical Field Stimulation Elicited Contractile Responses In Isolated Rabbit Bladder Straight Muscle; The Role Of Cannabinoid And Vanilloid Receptors, Sevi̇l Özger İlhan, Gökçe Sevi̇m Öztürk Fi̇ncan, Yağmur Okçay, Derya Sebi̇le Koç, Celi̇l İlker Aşkin, Ayşe Kübra Ki̇bar, İsmai̇l Mert Vural, Yusuf Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Nicotine acts as an agonist of nicotinic acetylcholine receptors (nAChR). These receptors belong to a superfamily of ligand-gated ion channels. We previously demonstrated that nicotine increased electrical field stimulation (EFS)-induced contractile or relaxation responses, possibly by facilitating neurotransmitter release from nerve terminals in various rabbit tissues. Studies have shown that there is an interaction between the endocannabinoid and nicotinic systems. This study aimed to investigate the interaction between nicotine and the endocannabinoid system in the rabbit urine bladder and also investigate the enhancing effect of nicotine on EFS-induced contractile responses in rabbit isolated bladder smooth muscle and its interaction …
Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara
Assessment Of S-Nitrosothiol And Thiol/Disulfide Levels In Acute Coronary Syndrome Patients, Mehmet Murat Yi̇ği̇tbaşi, Abdullah Nabi̇ Aslan, Harun Kundi̇, Mücahi̇t Furkan Erkiliç, Özcan Erel, Haci Ahmet Kasapkara
Turkish Journal of Medical Sciences
Background/aim: The level of nitric oxide (NO) is important to protect the heart from ischemic damage in acute coronary syndrome (ACS) patients. S-nitrosothiol (SNO) is a molecule that represents the main form of NO storage in the vascular structure. In addition, dynamic thiol/disulfide homeostasis (TDH) is known to play an important role in maintaining the oxidant-antioxidant balance. In this study, our aim is to evaluate the oxidative/nitrosative stress status according to SNO level and TDH in patients with ACS. Materials and methods: The study included 124 patients who were admitted to the emergency service and 124 consecutive individuals who applied …
Investigation Of Ceftazidime-Avibactam Susceptibility In Clinical Isolates Of Gram-Negative Bacteria, Ridvan Dumlu, Neval Yurttutan Uyar, Meltem Ayaş, Ni̇lay Aksoy, Nur Öztürk, Ayşe Sesi̇n Kocagöz
Investigation Of Ceftazidime-Avibactam Susceptibility In Clinical Isolates Of Gram-Negative Bacteria, Ridvan Dumlu, Neval Yurttutan Uyar, Meltem Ayaş, Ni̇lay Aksoy, Nur Öztürk, Ayşe Sesi̇n Kocagöz
Turkish Journal of Medical Sciences
Background/aim: Our study investigated the susceptibility rate of ceftazidime-avibactam and the risk factors associated with its resistance by analyzing gram-negative bacteria isolated from various patient samples. Materials and methods: Between March and November 2020, 1119 gram-negative bacteria strains were isolated from patient samples in Acıbadem Healthcare Group hospitals; ceftazidime-avibactam susceptibility results were evaluated using a 10/4µg (Oxoid, UK) disc and evaluated according to Eucast 2020 recommendations. Patient and isolate characteristics that could be risk factors were retrospectively investigated and statistically analyzed using SPSS 25.0. Results: Male patients made up 52% (n = 581) of the study's total patient population, and …
The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut
The Effect Of Topically Administered Lavender Aromatherapy On The Pain Of Insulin Injection In Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial, Hati̇ce Demi̇rağ, Sevi̇lay Hi̇nti̇stan, Enes Bulut
Turkish Journal of Medical Sciences
Background/aim: Needle phobia occurs in more than half of diabetic patients due to the pain caused by frequent insulin injections. Therefore, this study evaluated the effect of topically administered lavender aromatherapy on the pain of insulin injections in diabetic patients. Materials and methods: In this double-blind randomized controlled and experimental study, patients who met the study criteria were divided into three groups; topical lavender oil (n = 60), placebo (n = 60), and control (n = 60) groups. The data were collected using the "Patient Information Form", the "Follow-up Form", the "Verbal Category Scale (VCS)", and the "Visual Analogue Scale …
Low Handgrip Strength Is Associated With Diabetic Foot Disease In Geriatric Patients With Type 2 Diabetes, Eren İmre, Neşe Koçakgöl, Erdi̇ İmre
Low Handgrip Strength Is Associated With Diabetic Foot Disease In Geriatric Patients With Type 2 Diabetes, Eren İmre, Neşe Koçakgöl, Erdi̇ İmre
Turkish Journal of Medical Sciences
Background/aim: This study aims to reveal the prevalence of low handgrip strength in older patients with type 2 diabetes who have diabetic foot disease and to assess the association of handgrip strength with diabetic foot disease in older patients with type 2 diabetes. Materials and methods: Eighty-nine geriatric patients with diabetic foot ulcers and 69 patients without diabetic foot ulcers who presented to the endocrinology outpatient clinic between August 2020 and November 2021 were included in the study. The exclusion criteria were the usage of steroids, stroke-induced quadriplegia, myopathy, disability, hemodialysis treatment, type 1 diabetes, patients under 65 years of …
Effect Of Vitamin D On Myocardial Remodeling And Inflammatory Status In Children With Congenital Heart Disease, Sabi̇re Gökalp, Fatma Sedef Tunaoğlu, Fatma Canbeyli̇, Semi̇ha Terlemez, Vi̇ldan Atasayan, Lati̇fe Arzu Aral, Serdar Kula, Ayşe Deni̇z Oğuz
Effect Of Vitamin D On Myocardial Remodeling And Inflammatory Status In Children With Congenital Heart Disease, Sabi̇re Gökalp, Fatma Sedef Tunaoğlu, Fatma Canbeyli̇, Semi̇ha Terlemez, Vi̇ldan Atasayan, Lati̇fe Arzu Aral, Serdar Kula, Ayşe Deni̇z Oğuz
Turkish Journal of Medical Sciences
Background/aim: Vitamin D insufficiency is a common public health problem that is often unrecognized in children with congenital heart disease, and is not generally evaluated at congenital heart disease (CHD) follow-up. Recent studies have suggested that inadequate vitamin D status may have an adverse effect on cardiovascular health. This study investigates the relationship between vitamin D levels and hemodynamic parameters in children with CHD. Methods: Included in the study 40 patients (25 females, 15 males) with CHD, who were evaluated for Ross heart failure score, vitamin D, parathyroid hormone (PTH), calcium, phosphorus, alkaline phosphatase (ALP), whole blood count (WBC) and …
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Clinicoradiological Evaluation Of Oxidative Stress Activity In Acute Cerebral Infarction In The First 24 H And The Qualitative Importance Of Dysfunctional Hdl In Stroke, Esra Demi̇r Ünal, Gönül Vural, Funda Eren, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Acute cerebral infarction (ACI) occurs as a result of instant disruption of vascular flow that causes disbalance between oxidative/antioxidative activity. We examined the relationship of serum neuro-oxidative stress parameters with stroke severity and infarct volume in ACI and emphasized the qualitative importance of high-density lipoprotein (HDL) on its relationship with myeloperoxidase (MPO) and paraoxonase-1 (PON1) in the acute period of stroke. Materials and methods: One hundred ACI patients applied within the first 24 h and 50 healthy volunteers were included. The patient group was evaluated with demographic data (including arrival serum biochemical assessment), clinical disability scores, infarct volume, serum …
Central Vein Sign: Comparison Of Multiple Sclerosis And Leukoaraiosis, Hüseyi̇n Gökhan Yavaş, Ergi̇n Sağtaş
Central Vein Sign: Comparison Of Multiple Sclerosis And Leukoaraiosis, Hüseyi̇n Gökhan Yavaş, Ergi̇n Sağtaş
Turkish Journal of Medical Sciences
Background/aim: Leukoaraiosis produces white matter lesions (WML) similar to multiple sclerosis (MS) on brain magnetic resonance imaging (MRI), and the distinction between these two conditions is difficult radiologically. This study aimed to investigate the role of the central vein sign (CVS) in susceptibility-weighted imaging (SWI) sequence in distinguishing MS lesions from leukoaraiosis lesions in Turkish population. Materials and methods: In this prospective study, axial SWI and sagittal three-dimensional fluid-attenuated inversion recovery (3DFLAIR) were obtained in 374 consecutive patients. The study consisted of 169 (89 MS patients, 80 patients with leukoaraiosis) patients according to the inclusion and exclusion criteria. Two observers …
The Correlations Between Dynamic Contrast Enhanced Magnetic Resonance Imaging And Immunohistochemical Data In Head And Neck Squamous Cell Carcinomas, Nuri̇ Karabay, Hande Meli̇ke Bülbül, Ersoy Doğan, Ahmet Ömer İki̇z, Gökseni̇l Bülbül, Sülen Sarioğlu
The Correlations Between Dynamic Contrast Enhanced Magnetic Resonance Imaging And Immunohistochemical Data In Head And Neck Squamous Cell Carcinomas, Nuri̇ Karabay, Hande Meli̇ke Bülbül, Ersoy Doğan, Ahmet Ömer İki̇z, Gökseni̇l Bülbül, Sülen Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) can in vivo characterize tumor microvascular environment. The aim of the present study was to reveal the DCE-MRI findings and to determine the correlation between these findings and immunohistochemical data in head and neck squamous cell carcinoma (HNSCC). Materials and methods: Thirty-three patients diagnosed with primary HNSCC were evaluated retrospectively. DCE-MRI was conducted in all cases. CD34, CD105, and ki-67 expressions were analyzed with immunohistochemistry in tissue sections to determine micro-vessel density and proliferative activity. Results: The DCE-MRI is a successful technique in distinguishing tumor tissue from normal tissue. It was determined …
Monitoring Renal Oxygenation Status By Near-Infrared Spectroscopy During Ureterorenoscopy In Children, Sema Şanal Baş, Meryem Onay, Çi̇ğdem Arslan Alici, Umut Alici, Baran Tokar
Monitoring Renal Oxygenation Status By Near-Infrared Spectroscopy During Ureterorenoscopy In Children, Sema Şanal Baş, Meryem Onay, Çi̇ğdem Arslan Alici, Umut Alici, Baran Tokar
Turkish Journal of Medical Sciences
Background/aim: Near-infrared spectroscopy (NIRS) monitoring demonstrates renal blood flow, perfusion, and oxygenation changes. This study aimed to evaluate the effects of pediatric endourological interventions (PEI) on regional oxygen saturation value (rSO2 ) using renal NIRS monitoring. Materials and methods: Patients having bilateral inguinal surgery (group I), cystoscopy (group II), and ureterorenoscopy (group III), 20 patients in each group, were included in the study. NIRS values before induction (T0) and at 5 min (T5), 10 min (T10), 15 min (T15), 20 min (T20), 25 min (T25), 30 min (T30) of the surgical procedure, and at the postextubation (Tend) were determined. The …
Assessment Of Hcv-Rna Test Results And Access Rates To Antiviral Treatment In Patients With Anti-Hcv Positivity-A 10-Year Analysis, Emi̇ne Türkoğlu, Zafer Parlak, Hüseyi̇n Şener Barut
Assessment Of Hcv-Rna Test Results And Access Rates To Antiviral Treatment In Patients With Anti-Hcv Positivity-A 10-Year Analysis, Emi̇ne Türkoğlu, Zafer Parlak, Hüseyi̇n Şener Barut
Turkish Journal of Medical Sciences
Background/aim: Currently, hepatitis C virus (HCV) infection can be cured by direct-acting antivirals (DAAs). In this study, we aimed to find the rate of viremia among patients with a positive anti-HCV test and the rate of antiviral treatment given to viremic patients. We also aimed to reach patients with anti-HCV positivity but not tested for HCV-RNA, and patients, who were diagnosed with HCV-RNA positivity but received no treatment. Materials and methods: In this study, individuals tested for anti-HCV in Tokat Gaziosmanpaşa University Research and Application Hospital in the period between January 2010 and January 2020 were reviewed retrospectively. Anti-HCV positive …
Effect Of Tocilizumab On Intensive Care Patients With Covid-19 Pneumonia, A Retrospective Cohort Study, Mehtap Pehli̇vanlar Küçük, Ahmet Oğuzhan Küçük, Ayşegül Pehli̇vanlar, Emi̇ne Sevi̇l Ayaydin Mürtezaoğlu, Kadi̇r Çoban, Gamze Kiliç, Olcay Ayçi̇çek, Funda Öztuna, Yilmaz Bülbül, Tevfi̇k Özlü
Effect Of Tocilizumab On Intensive Care Patients With Covid-19 Pneumonia, A Retrospective Cohort Study, Mehtap Pehli̇vanlar Küçük, Ahmet Oğuzhan Küçük, Ayşegül Pehli̇vanlar, Emi̇ne Sevi̇l Ayaydin Mürtezaoğlu, Kadi̇r Çoban, Gamze Kiliç, Olcay Ayçi̇çek, Funda Öztuna, Yilmaz Bülbül, Tevfi̇k Özlü
Turkish Journal of Medical Sciences
Backround/aim: In this study, the efficacy of an IL-6 antagonist, Tocilizumab, administered in the early period was studied in intensive care patients with COVID-19 pneumonia followed by hypoxic and systemic inflammation not receiving mechanical ventilation support. Materials and methods: Patients with COVID-19 pneumonia who have signs of hypoxia and systemic inflammation and/or who have acute bilateral infiltrates on chest radiograph and who received tocilizumab treatment were compared with the patients who received standard medical therapy. Patients who were followed up with COVID-19 pneumonia and respiratory failure between March 2020 and March 2021 were retrospectively evaluated in the study. A 400 …
Interstitial Lung Disease In Patients With Systemic Lupus Erythematosus: A Cohort Study, Naci̇ Şenkal, Esen Kiyan, Ali̇ Aslan Demi̇r, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal, Bahar Artim Esen
Interstitial Lung Disease In Patients With Systemic Lupus Erythematosus: A Cohort Study, Naci̇ Şenkal, Esen Kiyan, Ali̇ Aslan Demi̇r, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal, Bahar Artim Esen
Turkish Journal of Medical Sciences
Background/aim: Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of organ/system involvement. Respiratory system involvement is common in these patients and usually manifests itself by disorders of the lung parenchyma, pleura, pulmonary vasculature or diaphragm. In this study, we sought to determine the frequency of interstitial lung disease (ILD) in patients with SLE and associated risk factors. Materials and methods: Three hundred randomly chosen patients with SLE were included. Chest x-ray (CXR), lung spirometry and carbon monoxide diffusion test (DLCO) were performed. High-resolution thorax computed tomography (HRCT) was performed for a definite diagnosis of ILD. Results: Of …
Investigation Of The Expression Levels Of Cdh1, Fhit, Pten, And Ttpal Genes In Colorectal Tumors, Evri̇m Suna Arikan Söylemez, Zafer Söylemez, Murat Çi̇lekar, Yüksel Arikan, Çi̇ğdem Tokyol, İbrahi̇m Hali̇l Kenger, Mustafa Solak
Investigation Of The Expression Levels Of Cdh1, Fhit, Pten, And Ttpal Genes In Colorectal Tumors, Evri̇m Suna Arikan Söylemez, Zafer Söylemez, Murat Çi̇lekar, Yüksel Arikan, Çi̇ğdem Tokyol, İbrahi̇m Hali̇l Kenger, Mustafa Solak
Turkish Journal of Medical Sciences
Background/aim: The main aim of the study is to assess expression levels of CDH1, FHIT, PTEN, and TTPAL genes in tumors and peripheral bloods of colorectal cancer patients in staged I-IV. Materials and methods: Gene expression analysis of related genes were performed for tumor tissues and peripheral blood samples of 51 colorectal cancer patients and colon tissues and blood samples of 5 healthy individuals. The real-time-PCR reaction method was used for the analysis. Results: Alteration of mRNA levels of related genes in tumor tissues of colorectal cancer cases was determined compared to control tissues. GAPDH and TBP were used for …
Germline Variant Screening With Targeted Next Generation Sequencing In Prostate Cancer: Phenotype-Genotype Correlation, Ali̇ Yavuz Çakir, Kuyaş Heki̇mler Öztürk, Alper Özorak
Germline Variant Screening With Targeted Next Generation Sequencing In Prostate Cancer: Phenotype-Genotype Correlation, Ali̇ Yavuz Çakir, Kuyaş Heki̇mler Öztürk, Alper Özorak
Turkish Journal of Medical Sciences
Background/aim: Next generation sequencing provides new information about the molecular pathogenesis of cancer. We used a targeted NGS-based multiple gene panel comprising prostate cancer (PCa) predisposing genes to assess the prevalence of germline mutations in PCa patients. Material and methods: In a cohort of twenty-one PCa patients with a family history of cancer, a targeted multigene panel consisting of 39 genes associated with hereditary cancer was created and analyzed using the next generation sequencing method. The novel and pathogenic mutations detected were confirmed by Sanger sequencing method. Thereafter, the data obtained were evaluated using different genomic variant classifiers and databases. …
Developing The Nausea And Vomiting Thermometer Scale In Children With Cancer, Asli Akdeni̇z Kudubeş, Murat Bektaş
Developing The Nausea And Vomiting Thermometer Scale In Children With Cancer, Asli Akdeni̇z Kudubeş, Murat Bektaş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to develop the Nausea and Vomiting Thermometer Scale (NVTS) in children with cancer. Materials and methods: This methodological study was conducted on 250 children with cancer at the research and training university hospital in Turkey between September 2019 and January 2020. The t-test, the ROC analysis, the Diagnostic index, and the Youden index were used for determining the scale of the cutting point. The regression analysis, the intra-class correlation coefficient, and the Bland- Altman analysis were used for the data analysis. Results: The scale-level content validity index was .94, which was coherent. As a result of …
Nonscarring Scalp Alopecia: Which Laboratory Analysis Should We Perform On Whom?, Ümran Öner, Necmetti̇n Akdeni̇z
Nonscarring Scalp Alopecia: Which Laboratory Analysis Should We Perform On Whom?, Ümran Öner, Necmetti̇n Akdeni̇z
Turkish Journal of Medical Sciences
Background/aim: Vitamins and minerals are thought to play an essential but not entirely clear role in developing, preventing, and treating nonscarring alopecia. Telogen effluvium, androgenetic alopecia, and alopecia areata are the most common forms of nonscarring alopecias. We would like to present a different perspective on laboratory abnormalities in patients with nonscarring alopecia. Materials and methods: A total of 467 patients (287 females, 180 males) were included retrospectively: One hundred and sixty patients in the telogen effluvium group, 101 patients in the androgenetic alopecia group, 99 patients in the alopecia areata group, and 107 patients in the hair loss group …
Bio-Clinical Evaluation Of Collateral Score In Acute Middle Cerebral Artery Occlusion, Esra Demi̇r, Hesna Bektaş, Hasan Bayindir, Oğuzhan Kurşun
Bio-Clinical Evaluation Of Collateral Score In Acute Middle Cerebral Artery Occlusion, Esra Demi̇r, Hesna Bektaş, Hasan Bayindir, Oğuzhan Kurşun
Turkish Journal of Medical Sciences
Background/aim: Acute ischemic stroke (AIS) is characterized as a neurological deficit owing to an acute focal damage to the brain by cerebral infarction. A collateral score is the most significant factor evaluating the prognosis of AIS, its relationship with demographic data, serum biochemical parameters, and clinical disability in this field. Materials and methods: We conducted a single-center retrospective study with 100 patients with AIS within the first 6 h of ischemic stroke. Data for consecutive AIS patients were collected from February 2019 to May 2020. The collateral score was assessed by using developed scoring systems defined by Maas et al. …
Utility Of Etco2 To Predict Hemorrhagic Shock In Multiple Trauma Patients, Gülşen Öztürk Örmeci̇, Özlem Yi̇ği̇t, Oktay Eray
Utility Of Etco2 To Predict Hemorrhagic Shock In Multiple Trauma Patients, Gülşen Öztürk Örmeci̇, Özlem Yi̇ği̇t, Oktay Eray
Turkish Journal of Medical Sciences
Background/aim: For identifying hemorrhagic shock in trauma patients, some objective data are needed. The use of base excess (BE) and lactate values have been originated. In this study, it was aimed to determine the usability of end tidal carbon dioxide (ETCO2) in patients with multiple trauma for recognizing hemorrhagic shock. Materials and methods: Patients who were admitted to the emergency department between June 2019 and February 2020 with high- energy multiple trauma were included in the study. ETCO2 and BE values were measured. Correlation coefficients were calculated to determine correlations between ETCO2 and BE levels. Results: One hundred and twenty-two …
Could Computed Tomography Histogram Analysis Add Value To The Diagnosis Of Cholesteatoma?, Nursel Yurttutan, Nagi̇han Bi̇lal, Betül Kizildağ, Adem Doğaner
Could Computed Tomography Histogram Analysis Add Value To The Diagnosis Of Cholesteatoma?, Nursel Yurttutan, Nagi̇han Bi̇lal, Betül Kizildağ, Adem Doğaner
Turkish Journal of Medical Sciences
Background/aim: To investigate the potential role of computed tomography (CT) histogram analysis in differentiating cholesteatoma (CHS) and non-cholesteatoma (NCHS). Materials and methods: We evaluated 77 temporal bone CT images (from November 2016 to February 2020) that were obtained pre- operatively (mean age, 37.10±17.27 years in CHS; 36.72±16.08 years in NCHS group). Histogram analyses of the resulting XML files were conducted using the R Project 3.3.2 program. ROC analysis was used to find threshold values, and the diagnostic efficiency of these values in differentiating CHS-NCHS was determined. Results: The CT images of 41 CHS (53.25%) and 36 NHCS cases (46.75%) were …
The Lumbar Erector Spinae Plane Block: A Cadaveric Study, Serdar Kokar, Ahmet Ertaş, Özlem Mercan, Fatma Güler Yildirim, Ömer Alp Taştan, Kenan Akgün
The Lumbar Erector Spinae Plane Block: A Cadaveric Study, Serdar Kokar, Ahmet Ertaş, Özlem Mercan, Fatma Güler Yildirim, Ömer Alp Taştan, Kenan Akgün
Turkish Journal of Medical Sciences
Background/aim: The aim of this cadaveric study was to investigate the erector spinae plane block (ESPB) in lumbar region and to elucidate the possible mechanisms of action of these injections in lumbar radicular pain by means of detecting expected dye dispersion to the neural structures. Materials and methods: Ultrasound-guided lumbar ESPB was performed in three formaldehyde-embalmed human cadavers. For this purpose, a 10 mL of methylene blue was injected into the fascial space between the L4 transverse process and the erector spinae muscles. Then, the cadavers were dissected, the cephalocaudal and lateral spread of the dye was examined, and the …
A High-Fat And High-Fructose Diet Lowers The Cecal Digesta's Weight And Short-Chain Fatty Acid Level Of A Sprague-Dawley Rat Model, Etik Sulistyowati, Dian Handayani, Setyawati Soeharto, Achmad Rudijanto
A High-Fat And High-Fructose Diet Lowers The Cecal Digesta's Weight And Short-Chain Fatty Acid Level Of A Sprague-Dawley Rat Model, Etik Sulistyowati, Dian Handayani, Setyawati Soeharto, Achmad Rudijanto
Turkish Journal of Medical Sciences
Background/aim: This study aimed to analyze the effect of a high-fat and high-fructose diet (HFFD) on the digesta weight and short- chain fatty acid (SCFA) levels of cecal digesta in rats. Materials and methods: This study was an experimental study with a posttest-only control group design with male Sprague-Dawley strain rats as the samples. A total of 36 rats were divided into two groups with normal diet (N) and modified HFFD. The data of energy intake, nutrients and fiber, body weight, Lee index, abdominal circumference, digesta weight, and SCFA levels of cecal digesta were collected. Results: The results showed an …