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Full-Text Articles in Medicine and Health Sciences

Plasma Fibronectin And Urineglycosaminoglycane Levels In Rheumatic Diseases, Nuriye Mete, Mahmut Mete, İ. Hakkı Öztürk, Leyla Çolpan Jan 1998

Plasma Fibronectin And Urineglycosaminoglycane Levels In Rheumatic Diseases, Nuriye Mete, Mahmut Mete, İ. Hakkı Öztürk, Leyla Çolpan

Turkish Journal of Medical Sciences

In this study, plasma fibronectin and urine glycosaminoglycane levels were determined spectrophotometrically in 20 Rheumatoid arthritis, 10 Ankilosing spondilites, 22 osteoarthrosis and 21 healthy control subjects. The mean levels of Fibronectin (\mug/ml) were 413.3±97 in patients with rheumatoid arthritis, 325.5±93.5 in ankilosing spondilites, 439.1±120.3 in osteoarthrosis and 302.2±60.1 in the control group. The ratio of urine glycosaminoglycan excretion to creatinine (g/mol) was 4.52±2.64 in patients with rheumatoid arthritis, 4.18±1.52 in patients with ankilosing spondilites, 2.72±1.19 in osteoarthrosis and 2.21±1.02 in the control group. Plasma Fibronectin levels were significantly higher in rheumatoid arthritis and osteoarthrosis when compared to the control group …


Distribution Of Tamoxifen In Rat Tissues Duringsteady-State Treatment, Ayşe Kafkasli, Erkan Ünlenen, Beyhan Demi̇rhan, Saim Yoloğlu Jan 1998

Distribution Of Tamoxifen In Rat Tissues Duringsteady-State Treatment, Ayşe Kafkasli, Erkan Ünlenen, Beyhan Demi̇rhan, Saim Yoloğlu

Turkish Journal of Medical Sciences

Tamoxifen citrate (TAM), a nonsteroidal antiestrogen, is a drug of choice in the endocrine treatment for all stages of breast cancer in both pre and postmenopausal patients. The tissue distrubution of TAM alone and combined with medroxyprogesterone acetate (MPA) following long-term p.o. administration in immature rats is investigated in the present study. The highest consentrations of TAM has been found in the hypophysis in both groups. TAM consentrations were effected by MPA treatment in the liver and kidneys.


A New Phenotype In The Phosphoğlucomutase1 (Pgm1) System, Pgm1*W32, E. Ferda Perçi̇n, A. İsmihan Göze Jan 1998

A New Phenotype In The Phosphoğlucomutase1 (Pgm1) System, Pgm1*W32, E. Ferda Perçi̇n, A. İsmihan Göze

Turkish Journal of Medical Sciences

Red cell phosphOĞLUcomutase 1 (PGM1) enzyme, which is a phosphotransferase, has 3 common and 31 rare phenotypes. In this study, we have identified a new phenotype for this enzyme which has not been reported previously using cellulose acetate electrophoresis technique. This phenotype has also been identified for the first time for Turkish population and called PGM1*W32.


The Seminal Fluid Isoenzyme Ldh-C4 In Infertilemen, Meral Fadiloğlu, Cevval Ulman, Banu Önvural, Ata Önvural Jan 1998

The Seminal Fluid Isoenzyme Ldh-C4 In Infertilemen, Meral Fadiloğlu, Cevval Ulman, Banu Önvural, Ata Önvural

Turkish Journal of Medical Sciences

In order to determine the seminal activity of LDH-C4 and to investigate its correlation with other fertility indexes, we studed total LDH, total CK avtivities, and LDH-C4 in relation to sperm count, motility and sperm motility index (SMI). SMI is the measurement of electro-optical fluctuations caused by motile sperm. Total LDH and total CK were determined with a Technicon RA 1000 analyser, and LDH isoenzymes with Helena Lab. isoenzyme kits. The results in 23 infertile men showed that LDH-C4 activity was either absent (4 cases), or decreased (19 cases). LDH-C4 showed a positive correlation with total LDH, sperm count and …


Helicobacter Pylori Seropositivity In Children Withrecurrent Abdominal Pain, Engin Günel, Duygu Findik, Fatma Çağlayan, Zerrin Topgaç Jan 1998

Helicobacter Pylori Seropositivity In Children Withrecurrent Abdominal Pain, Engin Günel, Duygu Findik, Fatma Çağlayan, Zerrin Topgaç

Turkish Journal of Medical Sciences

Recurrent abdominal pain (RAP) is a significant problem in pediatric patients, and there has been much recent interest in the role that Helicobacter pylori (Hp) might play in this disorder. The aim of the study was to determine the prevalance of Hp infection in children with RAP, and to determine whether there was an association between Hp and RAP. The study was conducted on 50 children with RAP and 20 asymptomatic children admitted for inguinal surgery as a control group. Serum samples from the 70 children were tested for anti-Hp Ig G and anti-Hp Ig A by ELISA. Of the …


A Case Of Atypical Cogan's Syndrome And Reviewof Literature, Murat Aksu, Ali Özdemir Ersoy, Sarper Karaküçük, Hakkı Doğan Jan 1998

A Case Of Atypical Cogan's Syndrome And Reviewof Literature, Murat Aksu, Ali Özdemir Ersoy, Sarper Karaküçük, Hakkı Doğan

Turkish Journal of Medical Sciences

No abstract provided.


The Effect Of Tamoxifen On The Neonataldevelopment Of Rat Penis, Engin Deveci̇, Yusuf Nergi̇z, Serap İnalöz, Murat Akkuş, M. Aydın Ketani̇, A. Reşit Ersay Jan 1998

The Effect Of Tamoxifen On The Neonataldevelopment Of Rat Penis, Engin Deveci̇, Yusuf Nergi̇z, Serap İnalöz, Murat Akkuş, M. Aydın Ketani̇, A. Reşit Ersay

Turkish Journal of Medical Sciences

In rats penis development a seen two stages in prenatal life, the second stage is androgen hormone dependent chondrocyte and osteocyte differentiation period. To investigate Tamoxifane (Tx) administration on the developmental anomalies of penis. The newborn male rats were injected with 100 µg Tamoxifen subcutaneously from the day of birth to fifth day. This changes in Os penis and glans penis were investigated after the rats had been sacrificed and their penis were removed on the days 14.0, 21.0, 28.0, 35.0 and 60.0 Having been fixed in neutral formaline of 10%, the totally taken penis werembedded into paraffin blocks. The …


The Inhibitory Effect Of Zinc On Imipenem Andmeropenem Susceptibility Of Pseudomonasaeruginosa, Selahattin Atmaca, Ramazan Çiçek, Kadri Gül Jan 1998

The Inhibitory Effect Of Zinc On Imipenem Andmeropenem Susceptibility Of Pseudomonasaeruginosa, Selahattin Atmaca, Ramazan Çiçek, Kadri Gül

Turkish Journal of Medical Sciences

In this study we have showed that zinc ion has an inhibitory activity on imipenem and meropenem suspectibility of Pseudomonas aeruginosa. When zinc ion concentration of Mueller-Hinthon agar (MHA) media was gradually increased the zone diameters of imipenem and meropenem gradually decreased. So we concluded that zinc concentration in the media might effect imipenem and meropenem susceptibility of Pseudomonas aeruginosa and might indicate false resistance to imipenem and meropenem. Therefore the use of these antipseudomonal antibiotics in Pseudomonas infections may be restricted.


The Natural Menopause Age Of Women Inerzurum And Factors Influencing The Age Atmenopause, Nesrin Rei̇s, Türkân Pasi̇nli̇oğlu, Şenol Dane Jan 1998

The Natural Menopause Age Of Women Inerzurum And Factors Influencing The Age Atmenopause, Nesrin Rei̇s, Türkân Pasi̇nli̇oğlu, Şenol Dane

Turkish Journal of Medical Sciences

In this study the age at menopause and factors influencing age at menopause were investigated by a questionnaire in 282 women. The mean age of menopause was found to be 45.3 years and ranged from 35 to 54. Positive relationships were found between age at menopause and marital satus, body mass index, gravidity, parity, age at menarche, menstruation and menstruation bleeding period. Whereas negative relationships were found between age at menopause and smoking, age at first birth, abortion status and oral contraceptive use.


Determination Of The Prevalence Of Latexsensitivity By In Vivo And In Vitromethods Among Hospital Employees Andallergic Patients, Ayşe Füsun Kalpaklioğlu, Lütfü Gürbüz, Zeynep Misirligi̇l Jan 1998

Determination Of The Prevalence Of Latexsensitivity By In Vivo And In Vitromethods Among Hospital Employees Andallergic Patients, Ayşe Füsun Kalpaklioğlu, Lütfü Gürbüz, Zeynep Misirligi̇l

Turkish Journal of Medical Sciences

Background: Latex has been documented as causing immediate hypersensitivity reactions ranging from contact urticaria to severe anaphylaxis. The prevalence of latex allergy appears to be higher in certain risk groups due to increased exposure or to an increased intrinsic predilection for atopy. The purpose of the present study was both to assess latex sensitivity in a large group of allergic patients and in hospital emyloyees and to evaluate the relationship between latex sensitivity and skin prick test (SPT) responses to fruits as well as inhalant allergens. Methods: This study was designed prospectively in a randomized manner. SPTs were performed and …


Purification Of Casein Kinase Ii From Lung Tissueand Kinetic Evaluations With Polyamines Andmyc-Oncoprotein, Nesrin Gündoğus-Özcanli, Wayne E. Criss Jan 1998

Purification Of Casein Kinase Ii From Lung Tissueand Kinetic Evaluations With Polyamines Andmyc-Oncoprotein, Nesrin Gündoğus-Özcanli, Wayne E. Criss

Turkish Journal of Medical Sciences

The overall goal of this study was to seek molecular linkages between polyamines, casein kinase II, and the myc oncoprotein by using a cell-free, highly purified enzyme kinetic analysis. Casein kinase II (CKII) was purified from sheep lung tissue by using an original 3-column/3-day set of procedures (DEAE cellulose, Sepharose 6L-4B, and poly-L- lysine agrose affinity chromotographies). CKII was purified approximately 550-fold with a recovery of near 40% and a final specific activity of about 250,000 pmol of phosphorylated protein substrate (casein)/min/mg of enzyme protein. Kinetic evaluations with the purified CKII using Mg-GTP as a phosphate donor, etiher casein or …


Translocation 13;14 Associated Withmyelodsplastic Syndrome In Down's Syndrome, Gül Sapmaz, Ferda Özkinay, Hasan Yüksel, Cihangir Özkinay, Figen Akdeni̇zli̇oğlu, Nejat Topçuoğlu, Şenay Öztop Jan 1998

Translocation 13;14 Associated Withmyelodsplastic Syndrome In Down's Syndrome, Gül Sapmaz, Ferda Özkinay, Hasan Yüksel, Cihangir Özkinay, Figen Akdeni̇zli̇oğlu, Nejat Topçuoğlu, Şenay Öztop

Turkish Journal of Medical Sciences

No abstract provided.


Metabolic Effects Of Isradipine In Normotensiveniddm Patients With Microalbuminuria, Tevfik Sabuncu, Hüseyin Vural, Mahmut Dalmaz, Yaşar Nazligül, Abdurrahim Koçyi̇ği̇t, Özcan Erel, Şenel Avci Jan 1998

Metabolic Effects Of Isradipine In Normotensiveniddm Patients With Microalbuminuria, Tevfik Sabuncu, Hüseyin Vural, Mahmut Dalmaz, Yaşar Nazligül, Abdurrahim Koçyi̇ği̇t, Özcan Erel, Şenel Avci

Turkish Journal of Medical Sciences

The aim of this study was to determine whether isradipine affects microalbuminuria and other biochemical parameters related to glucose and lipid metabolisms. 18 subjects, 40 to 73 years of age, with NIDDM for 0 to 21 years, blood pressure²140/90 mmHg in the absence of antihypertensive treatment, and persistent urinary albumin excretion rate (UAER) 30 to 300 mg/day, received sustained-release (SRO) formulation isradipine at dosages of 5 mg once daily for 3 months. The effects of isradipine on microalbuminuria, fasting plasma glucose, plasma lipids, plasma creatinin, uric acid, C-peptide, insulin, HbA 1c , fructosamine, systolic and diastolic blood pressure and heart …


Association Of Hla Type With Pseudoexfoliationof The Lens Capsule, Hakkı Doğan, Türkan Patiroğlu, Engin Baykal, Kuddusi Erkiliç Jan 1998

Association Of Hla Type With Pseudoexfoliationof The Lens Capsule, Hakkı Doğan, Türkan Patiroğlu, Engin Baykal, Kuddusi Erkiliç

Turkish Journal of Medical Sciences

Exfoliation of the lens capsule is asymptomatic but it is associated with the development of glaucoma and blindness if undetected and untreated. The occurrence of exfoliation varies widely in different countries where the population is ethnically homogeneous. It is suggested that both genetic and environmental influences are important in the development of exfoliative syndrome (ES). This study was carried out to determine if there was any relation between ES and HLA. HLA antigen types were determined in 45 patients with exfoliative syndrome. We found a strong association between HLA-A2, HLA-DR5, HLA B21 and HLA-DR7 and the existence of ES (Chi …


The Effects Of Different Metal Surfacetreatments On Marginal Microleakage In Resin-Bondedrestorations, Y. Şinasi Saraç, Kürsat Eser, Bedri Beydemi̇r, Tanju Akbay Jan 1998

The Effects Of Different Metal Surfacetreatments On Marginal Microleakage In Resin-Bondedrestorations, Y. Şinasi Saraç, Kürsat Eser, Bedri Beydemi̇r, Tanju Akbay

Turkish Journal of Medical Sciences

Margins are one of the most important aspects in the success of restorations. Therefore, we evaluated the effects of different metal surface treatments on the marginal microleakage of a resinbonded non-precious alloy (Remanium CS). After alloy surfaces were roughened by chemical etching or sandblasting the tooth and metal specimens were bonded together in pairs with a chemically curing resin cement (Panavia 21 EX) and placed in methylene blue dye. Spectrophotometry was used to assess marginal leakage. Statistical analysis was completed using the ANOVA test. No statistically significant difference in leakage was found between the groups (F=0.4387, p>0.05).


Digital Amputations Caused By Amniotic Bandsa Case Report, Volkan Baltaci, Didem Akyol, Davut Gül, Bekir Sıtkı Sayli Jan 1998

Digital Amputations Caused By Amniotic Bandsa Case Report, Volkan Baltaci, Didem Akyol, Davut Gül, Bekir Sıtkı Sayli

Turkish Journal of Medical Sciences

No abstract provided.