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Articles 2641 - 2670 of 4871
Full-Text Articles in Medicine and Health Sciences
Prevalence Of Hypertension And Its Association With Obesity Among Schoolchildren Aged 6-15 Living In Sakarya Province In Turkey, Fati̇h Muhammed Önsüz, Fi̇gen Demi̇r
Prevalence Of Hypertension And Its Association With Obesity Among Schoolchildren Aged 6-15 Living In Sakarya Province In Turkey, Fati̇h Muhammed Önsüz, Fi̇gen Demi̇r
Turkish Journal of Medical Sciences
Background/aim: Childhood hypertension and its association with obesity are becoming important issues worldwide. The prevalence of hypertension and obesity are growing in both developed and developing countries. This paper aimed to determine the prevalence of hypertension among school-aged children in Sakarya (western part of Turkey) and to determine whether or not obesity is associated with hypertension. Materials and methods: Twelve schools were randomly selected from an area in the center of the Sakarya. A total of 2166 students participated in the study. The students were visited at school, and their weights, heights, and blood pressures were measured. The World Health …
Effects Of Pretreatment With Esmolol And Lidocaine On Injection Pain Androcuronium-Induced Withdrawal Response, Jüli̇de Ergi̇l, Fatma Kavak Akelma, Derya Özkan, Gözde Bumi̇n Aydin, Ayşe Gürel, Meli̇h Akinci
Effects Of Pretreatment With Esmolol And Lidocaine On Injection Pain Androcuronium-Induced Withdrawal Response, Jüli̇de Ergi̇l, Fatma Kavak Akelma, Derya Özkan, Gözde Bumi̇n Aydin, Ayşe Gürel, Meli̇h Akinci
Turkish Journal of Medical Sciences
Background/aim: We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response. Materials and methods: We enrolled a total of 81 patients in the study. Patients were randomly assigned to receive either 10 mL of 0.9% NaCl (Group P), esmolol 1 mg/kg (Group E), or lidocaine 1.0 mg/kg (Group L). A subparalyzing dose of rocuronium 0.05 mg/kg was administered to all patients and its effects were recorded. Anesthesia was induced with intravenous propofol and intravenous rocuronium 0.5 mg/kg in all groups. The withdrawal movements of the …
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Herbal Self-Medication Use In Patients With Diabetes Mellitus Type 2, Ivana Damnjanovic, Dusanka Kitic, Nikola Stefanovic, Snezana Zlatkovic-Guberinic, Aleksandra Catic-Djordjevic, Radmila Velickovic-Radovanovic
Turkish Journal of Medical Sciences
Background/aim: A considerable number of patients suffering from diabetes mellitus (DM) turn to self-medication using medicinal plants, preparations, and medicine. The aim of this study was to investigate self-medication using medicinal plants and the potential influence of health care professionals' advice or media information regarding the use of herbal dietary supplements with hypoglycemic effect in a population of patients with type 2 DM. Materials and methods: This research, in the form of an analytic cross-sectional study, was conducted in 6 pharmacies in the territory of Nis, Serbia, during October 2013. The criterion set for the study was to include patients …
Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut
Evaluation Of Patency Following Revision Technique Ofhigh-Velocity Arteriovenous Fistula, Ümi̇t Halici, Mehmet Ali̇ Kaygin, Özgür Dağ, Ahmet Aydin, Hüsnü Kami̇l Li̇mandal, Ümi̇t Arslan, Eyüp Serhat Çalik, Bi̇lgehan Erkut
Turkish Journal of Medical Sciences
Background/aim: The objective of this study is to report our experience with surgical revision of dialysis access-induced ischemia syndrome. Materials and methods: Between January 2005 and July 2013, 1254 patients underwent arteriovenous fistula operation, and 86 of them [53 males, mean age: 55 ± 25 (range: 25 to 75) years; 33 females, mean age: 50 ± 20 (range: 30 to 70) years] subsequently developed steal syndrome. These patients were treated with arterial pressure-controlled polytetrafluoroethylene banding or constriction with polypropylene suturing technique. Patients were followed in the outpatient clinic at regular intervals. Results: Symptoms were not relieved during the first 15 …
Value Of Prealbumin In Assessment Of Nutrition For Critically Ill Patients, Mehmet Ağilli, Şafak Eki̇nci̇
Value Of Prealbumin In Assessment Of Nutrition For Critically Ill Patients, Mehmet Ağilli, Şafak Eki̇nci̇
Turkish Journal of Medical Sciences
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Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör
Why Is Alzheimer's Disease Confused With Other Dementias?, Dursun Aygün, İbrahi̇m Levent Güngör
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common cause of dementia. The cardinal manifestation of AD is progressive loss of memory. However, there are some nonamnestic presentations of AD, also called atypical AD. Symptoms of AD can sometimes start suddenly. In the presence of atypical symptoms or sudden onset, it may be difficult to distinguish AD from other dementias. We would like to discuss the confusing features of atypical AD that mimic other dementias. In this review, the literature associated with confusing features of AD, suggesting other dementia syndromes, is reviewed. In addition, a case of semantic dementia (SD) with the …
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Postoperative Cognitive Dysfunction And Alzheimer Disease, Berri̇n Işik
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β …
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Potential Genetic Biomarkers In The Early Diagnosisof Alzheimer Disease: Apoe And Bin1, Gülhan Kaya, Esra Gündüz, Muradi̇ye Acar, Ömer Faruk Hati̇poğlu, Burcu Acar, Ati̇lla İlhan, Mehmet Gündüz
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 …
Association Of Clu And Tlr2 Gene Polymorphisms With Late-Onsetalzheimer Disease In A Northwestern Iranian Population, Nasim Sohrabifar, Jalal Gharesouran, Mahnaz Talebi, Morteza Ghojazadeh, Seiied Mojtaba Mohaddes Ardebili
Association Of Clu And Tlr2 Gene Polymorphisms With Late-Onsetalzheimer Disease In A Northwestern Iranian Population, Nasim Sohrabifar, Jalal Gharesouran, Mahnaz Talebi, Morteza Ghojazadeh, Seiied Mojtaba Mohaddes Ardebili
Turkish Journal of Medical Sciences
Background/aim: A number of genetic variants from different genes have been reported to be related to late-onset Alzheimer disease (LOAD) susceptibility. From these genes, polymorphisms in CLU and TLR2 have been replicated in several studies. In this study we examined the association of rs11136000 in CLU and the TLR2 -196 to -174 del polymorphism with the risk of LOAD in a northwestern Iranian population. Materials and methods: We conducted a case-control study with a dataset of 160 LOAD patients and 163 healthy controls. To examine polymorphisms of CLU and TLR2 in LOAD we used the PCR/RFLP method and genotype frequencies …
Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci
Neurodegeneration In Ocular And Central Nervous Systems: Optical Coherence Tomography Study In Normal-Tension Glaucoma And Alzheimer Disease*, Muhsi̇n Eraslan, Eren Çerman, Osman Çeki̇ç, Sevcan Balci, Volkan Deri̇ci̇oğlu, Özlem Şahi̇n, Devran Süer, Biman Chabou, Emi̇ne Neşe Tuncer Elmaci
Turkish Journal of Medical Sciences
Background/aim: To evaluate, in vivo, the optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with normal-tension glaucoma (NTG) and those with Alzheimer disease (AD) in comparison with healthy subjects. Materials and methods: This cross-sectional study included 18 patients with NTG, 20 with AD, and 20 control subjects. An ophthalmologic examination and OCT scans of both eyes were performed in all patients. Results: There was a significant reduction in peripapillary RNFL thickness and macular GCC thickness and a significant increase in the global loss volume (GLV) rate in both the NTG …
Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi
Nerve Growth Factor Receptors In Dementia, Manoochehr Messripour, Abolfazl Nazarian, Azadeh Mesripour, Iman Mohammadi
Turkish Journal of Medical Sciences
Background/aim: Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids. The aim of this pilot study was to determine urine TNGFR levels in patients with dementia and to verify whether TNGFR can be used as a biomarker of dementia. Materials and methods: Twelve patients with dementia and 12 healthy individuals were asked to voluntarily participate in this study. Ages, sexes, and weights were matched. The first morning urine samples were collected …
The Value Of Fdg-Pet/Ct By Using 3-Dimensional Stereotactic Surface Projection Software Analysis In The Differential Diagnosis Of Dementia, Esra Arslan, Özgül Ekmekçi̇oğlu, Fatma Arzu Görtan, Zeynep Funda Engi̇n Akcan, Meli̇h Engi̇n Erkan, Haci Murat Emül, Meti̇n Halaç, Tevfi̇k Fi̇kret Çermi̇k, Keri̇m Sönmezoğlu
The Value Of Fdg-Pet/Ct By Using 3-Dimensional Stereotactic Surface Projection Software Analysis In The Differential Diagnosis Of Dementia, Esra Arslan, Özgül Ekmekçi̇oğlu, Fatma Arzu Görtan, Zeynep Funda Engi̇n Akcan, Meli̇h Engi̇n Erkan, Haci Murat Emül, Meti̇n Halaç, Tevfi̇k Fi̇kret Çermi̇k, Keri̇m Sönmezoğlu
Turkish Journal of Medical Sciences
Background/aim: To retrospectively reevaluate brain fluor-18-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging studies with 3-dimensional stereotactic surface projection (NEUROSTAT) software in order to detect changes in regional brain metabolism and to find out its contribution to the final diagnosis. Materials and methods: A total of 48 cases were included in this study. According to clinical evaluation and neuropsychometric test results, there were 17 (35%) patients with probable Alzheimer disease (AD), 17 (35%) patients with probable frontotemporal dementia (FTD), and 14 (30%) patients with undefined advanced dementia. Brain FDG-PET imaging studies were interpreted visually and also using 3-dimensional stereotactic surface projection. Results: …
A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci
A Turkish 3-Center Study Evaluation Of Serum Folic Acid And Vitamin B12 Levels In Alzheimer Disease, Nuri̇ye Nuray Ulusu, Gökhan Yilmaz, Zübeyde Erbayraktar, Ahmet Turan Evli̇ce, Sevgi̇ Aras, Görsev Yener, Aslihan Avci
Turkish Journal of Medical Sciences
Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients. Materials and methods: We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic …
Prevalence Of Cognitive Impairment And Related Risk Factors Incommunity-Dwelling Elderly In Kayseri, Turkey, Si̇bel Arguvanli, Si̇bel Akin, Eli̇f Deni̇z Şafak, Sali̇me Mucuk, Ahmet Öztürk, Mustafa Mümtaz Mazicioğlu, Hati̇ce Duygu Kizilçay, Şemsi̇nnur Göçer
Prevalence Of Cognitive Impairment And Related Risk Factors Incommunity-Dwelling Elderly In Kayseri, Turkey, Si̇bel Arguvanli, Si̇bel Akin, Eli̇f Deni̇z Şafak, Sali̇me Mucuk, Ahmet Öztürk, Mustafa Mümtaz Mazicioğlu, Hati̇ce Duygu Kizilçay, Şemsi̇nnur Göçer
Turkish Journal of Medical Sciences
Background/aim: The increased rate of elderly individuals in the general population leads to functional decline because of cognitive impairment (CImp). We aimed to detect the prevalence of CImp and related risk factors in community-dwelling elders living in an urban area (Kayseri, Turkey). Materials and methods: This is a cross-sectional, population-based study conducted in a sample of 900 community-dwelling elders aged 60 years and older. Cognitive status and depressive symptoms were assessed by standardized Mini Mental State Examination (MMSE) and the Geriatric Depression Scale (GDS), respectively. Results: The mean age of the participants was 71.6 ± 0.18 years, of whom 47.9% …
The Effectiveness Of Ultrasound Treatment For The Management Of Kneeosteoarthritis: A Randomized, Placebo-Controlled, Double-Blind Study, Serap Kapci Yildiz, Feyza Ünlü Özkan, İlknur Aktaş, Ayşe Duygu Şi̇lte, Meryem Yilmaz Kaysin, Naci̇ye Bi̇lgi̇n Badur
The Effectiveness Of Ultrasound Treatment For The Management Of Kneeosteoarthritis: A Randomized, Placebo-Controlled, Double-Blind Study, Serap Kapci Yildiz, Feyza Ünlü Özkan, İlknur Aktaş, Ayşe Duygu Şi̇lte, Meryem Yilmaz Kaysin, Naci̇ye Bi̇lgi̇n Badur
Turkish Journal of Medical Sciences
Background/aim: A randomized, placebo-controlled, double-blind study was designed to investigate the effectiveness of ultrasound therapy in primary knee osteoarthritis. Materials and methods: Ninety patients between 40 and 65 years of age having grade 2 and 3 bilateral knee osteoarthritis enrolled in the study were randomly assigned into 3 groups: continuous ultrasound, pulsed ultrasound, and placebo ultrasound. All patients were given a home exercise program. Patients were evaluated at baseline, at the end of the treatment, and at the second month after the treatment by a range of motion measurement, visual analog scale, Lequesne index for knee osteoarthritis, and Short Form-36 …
Beneficial Effects Of Melatonin And Bq-123 On The Rat Testis Damage Caused By Cigarette Smoke, Hüseyi̇n Aslan, Hakan Kesi̇ci̇, Zafer İsmai̇l Karaca, Bi̇rsen Özyurt, Ufuk Taş, Fati̇h Eki̇ci̇, Hasan Erdoğan, Fi̇kret Gevrek, Sevi̇l Çayli
Beneficial Effects Of Melatonin And Bq-123 On The Rat Testis Damage Caused By Cigarette Smoke, Hüseyi̇n Aslan, Hakan Kesi̇ci̇, Zafer İsmai̇l Karaca, Bi̇rsen Özyurt, Ufuk Taş, Fati̇h Eki̇ci̇, Hasan Erdoğan, Fi̇kret Gevrek, Sevi̇l Çayli
Turkish Journal of Medical Sciences
Several studies have demonstrated that cigarette smoke has detrimental effects on testicular function. However, it is unknown whether melatonin or BQ-123 has beneficial effects on the rat testis damage caused by cigarette smoke. The aim of the present study was to investigate the beneficial effects of melatonin or BQ-123 on the testicular damage caused by cigarette smoke. Materials and methods: Twenty Wistar rats were randomly divided into 4 equal groups: control group (n = 5), cigarette smoke group (n = 5), melatonin group (n = 5), and BQ-123 group (n = 5). At the end of 4 weeks, all the …
Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz
Parp Inhibition Prevents Acetaminophen-Induced Liver Injury And Increases Survival Rate In Rats, Melahat Dönmez, Bülent Uysal, Yavuz Poyrazoğlu, Yeşi̇m Er Öztaş, Türker Türker, Ümi̇t Kaldirim, Ahmet Korkmaz
Turkish Journal of Medical Sciences
Acetaminophen (APAP) overdose results in severe liver damage that may develop into acute liver failure. Recent studies have demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) decreases tissue necrosis and inflammation. We evaluated the efficacy of 3-aminobenzamide (3-AB), a PARP inhibitor, in a rodent model of APAP-induced hepatotoxicity. Materials and methods: Twenty-four Sprague-Dawley rats were divided equally into 3 experimental groups: sham group, APAP group, and APAP + 3-AB group. In the experimental treatment groups APAP was administered orally at 1 g/kg and, in the APAP + 3-AB group, 3-AB was administered intraperitoneally at a dose of 20 mg/kg exactly 1 …
Polymorphism Characteristics Of Hiv-1 Gp120 And 5 Hypervariable Regions, Neng Yao, Chunxia Zhang, Qi Liu, Jun Liu, Chiyu Zhang
Polymorphism Characteristics Of Hiv-1 Gp120 And 5 Hypervariable Regions, Neng Yao, Chunxia Zhang, Qi Liu, Jun Liu, Chiyu Zhang
Turkish Journal of Medical Sciences
To investigate polymorphism characteristics of HIV-1 gp120 and its 5 hypervariable regions. Materials and methods: Length polymorphism, potential number of N-linked glycosylation sites (PNGSs), and sequence characteristics of nearly all available global gp120 and its 5 hypervariable regions from HIV-1 subtypes A, B, C, D, G, and H were analyzed. Results: We found that the majority of HIV-1 gp120s have 496-515 amino acids and 21-30 PNGSs, suggesting that a gp120 with this length might be a good virus candidate for vaccine development. Among 5 hypervariable regions, the V3 regions had the lowest levels of length polymorphism and heterogeneity and less …
Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz
Protective Effects Of Royal Jelly Against Testicular Damage In Streptozotocin-Induced Diabetic Rats, Turan Karaca, Seli̇m Demi̇rtaş, İhsan Karaboğa, Süleyman Ayvaz
Turkish Journal of Medical Sciences
To examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Four weeks after the onset of diabetes, testicular apoptotic cell death was examined using immunohistochemical staining for caspase-3 and Ki67 staining for localization of proliferative cells. Results: Compared with the control, the body and …
An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu
An In Vitro And In Vivo Investigation Of The Cytotoxic Effects Of Caffeic Acid (3,4-Dihydroxycinnamic Acid) Phenethyl Ester And Bortezomib In Multiple Myeloma Cells, Ertan Altayli, Özgür Koru, Önder Öngürü, Tayfun İde, Cengi̇zhan Açikel, Meral Sarper, Mualla Pinar Elçi̇, Rahşan Ilikçi Sağkan, Erhan Astarci, Duran Tok, Sali̇m Özenç, Ali̇ Uğur Ural, Feri̇t Avcu
Turkish Journal of Medical Sciences
In this study, the in vitro and in vivo effectiveness of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) in combination with bortezomib, a proteasome inhibitor, was explored in multiple myeloma (MM) cells. Materials and methods: The cytotoxic effects of CAPE and bortezomib were determined by XTT cell proliferation assay. Apoptosis levels were analyzed with annexin V-fluorescein isothiocyanate, nuclear factor kappa beta (NF-\kappaB) was analyzed with electrophoretic mobility-shift assay, and interleukin (IL)-6 levels were analyzed with enzyme-linked immunosorbent assay to evaluate CAPE's mechanism of action. To investigate the in vivo effectiveness of CAPE and bortezomib, an experimental plasmacytoma model was induced …
Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali
Comparative Study Of Virulence Factors Among Esβl-Producing And Nonproducing Pseudomonas Aeruginosa Clinical Isolates, Maha Abd El Fattah Khalil, Fatma Ibrahim Sonbol, Abdelfattah Badr, Samh Samir Ali
Turkish Journal of Medical Sciences
\beta-Lactamase production is considered one of the most important resistance mechanisms among virulent Pseudomonas aeruginosa isolates. The aim of this study was to compare the production and antimicrobial resistance patterns of some virulence factors in extended spectrum \beta-lactamase (ES\betaL)-producing and nonproducing P. aeruginosa clinical isolates. Materials and methods: Out of 183 different clinical specimens, 104 Pseudomonas aeruginosa isolates were recovered. The isolates were screened for ESbL production using the double disk diffusion test and phenotypic confirmatory disk diffusion test. All isolates were tested for susceptibility to 25 antimicrobials, as well as for expression of various virulence factors including pigment, hemolysin, …
Investigation Of West Nile Virus Among Healthy Blood Donors In The Western Part Of Turkey, Servet Uluer Bi̇çeroğlu, Ersi̇n Karatayli, Arzu Bayram, Ajda Turhan, Aysu Deği̇rmenci̇, Yeşi̇m Aydinok, Abdurrahman Mi̇that Bozdayi, Şazi̇ye Rüçhan Sertöz
Investigation Of West Nile Virus Among Healthy Blood Donors In The Western Part Of Turkey, Servet Uluer Bi̇çeroğlu, Ersi̇n Karatayli, Arzu Bayram, Ajda Turhan, Aysu Deği̇rmenci̇, Yeşi̇m Aydinok, Abdurrahman Mi̇that Bozdayi, Şazi̇ye Rüçhan Sertöz
Turkish Journal of Medical Sciences
The West Nile virus (WNV) is a mosquito-borne flavivirus causing different forms of infection among humans, varying from asymptomatic illness to fetal central nervous system infection. Turkey lies within an endemic region for WNV. Transfusion of infected blood products is another well-documented major route of transmission. The aim of our study was to investigate the presence of WNV viremia among a healthy donor population from the western part of the country. Materials and methods: A total of 438 healthy volunteer blood donors were included in the study. The presence of WNV RNA was investigated by quantitative real-time reverse-transcriptase polymerase chain …
Efficacy Of Entecavir Treatment Among Chronic Hepatitis B Nucleos(T)Ide-Naïve And -Experienced Patients, Kadi̇r Çağatay Bi̇çer, Alpay Ari, Vecdi̇ Evren Genç, Si̇bel Özsu Caymaz, Meltem Avci, Fatma Bal
Efficacy Of Entecavir Treatment Among Chronic Hepatitis B Nucleos(T)Ide-Naïve And -Experienced Patients, Kadi̇r Çağatay Bi̇çer, Alpay Ari, Vecdi̇ Evren Genç, Si̇bel Özsu Caymaz, Meltem Avci, Fatma Bal
Turkish Journal of Medical Sciences
To evaluate the efficacy of entecavir (ETV) among chronic hepatitis B (CHB) nucleos(t)ide-naïve and -experienced patients in clinical practice. Materials and methods: In this retrospective study 85 CHB patients who had been receiving ETV and who attended our clinic since 2007 were included. Fifty patients were nucleos(t)ide analogue (NA)-naïve. Factors including sex, positive HBeAg, baseline HBV DNA level, baseline alanine aminotransferase level, and prior lamivudine (LAM) resistance were evaluated in terms of their predictive role in treatment response, which was defined as a serum HBV DNA decrease of
A New Utilization Area For Hyperbaric Oxygen? Improving Quality Of Stored Blood, Hakan Ay, Ramazan Yüksel, Kemal Şi̇mşek, Turgut Topal, Özgür Yeşi̇lyurt, Şükrü Öter, Ahmet Korkmaz, Mehmet Özler, Bülent Uysal, Hali̇l Yaman, Orhan Bedi̇r, Hayati̇ Bi̇lgi̇ç
A New Utilization Area For Hyperbaric Oxygen? Improving Quality Of Stored Blood, Hakan Ay, Ramazan Yüksel, Kemal Şi̇mşek, Turgut Topal, Özgür Yeşi̇lyurt, Şükrü Öter, Ahmet Korkmaz, Mehmet Özler, Bülent Uysal, Hali̇l Yaman, Orhan Bedi̇r, Hayati̇ Bi̇lgi̇ç
Turkish Journal of Medical Sciences
Since blood bags have the ability for diffusion of gases, we investigated whether hyperbaric oxygen (HBO) exposure affects several vital parameters of stored blood. Materials and methods: Bloods obtained from the same persons were used as both control and HBO groups and stored in pediatric bags with citrate-phosphate-dextrose solution. HBO administration was performed at 2.5 atm for 90 min, started 1 day after blood collection and repeated every 2 days for a total of 10 times. The study was terminated on the 21st day. Complete blood count, glucose, pH, and osmotic fragility values were measured every week. Results: Glucose and …
Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez
Serum Vegf Levels In Gastric Cancer Patients: Correlation With Clinicopathological Parameters, Celal İsmai̇l Bi̇lgi̇ç, Mesut Tez
Turkish Journal of Medical Sciences
To evaluate the predictive role of the circulating levels of vascular endothelial growth factor (VEGF) in gastric cancer patients. Materials and methods: This study is a case-control study. We measured serum VEGF levels of 30 patients aged between 34 and 83 years with gastric cancer and 30 patients without malignant pathology, operated on for benign pathologies, with ages ranging from 18 to 69. Results: Serum levels of VEGF were correlated with the tumor type classification (signet cell adenocarcinoma) and the presence of adjacent tissue invasion. There was also a positive correlation between serum VEGF and carcinoembryonic antigen levels. Conclusion: In …
Is There Any Impact Of Pet/Ct On Radiotherapy Planning In Rectal Cancer Patients Undergoing Preoperative Imrt?, Di̇clehan Kiliç, Serap Çatli, Şükran Ülger, Lütfi̇ye Özlem Kapucu
Is There Any Impact Of Pet/Ct On Radiotherapy Planning In Rectal Cancer Patients Undergoing Preoperative Imrt?, Di̇clehan Kiliç, Serap Çatli, Şükran Ülger, Lütfi̇ye Özlem Kapucu
Turkish Journal of Medical Sciences
To investigate the effect of positron emission tomography-computed tomography (PET/CT)-based contouring on dosimetric parameters in rectal cancer patients undergoing preoperative intensity-modulated radiation therapy (IMRT). Materials and methods: Preoperative radiation therapy plans with conformal radiotherapy (CRT) or IMRT were created and examined according to the CT- and PET/CT-based contouring of 20 rectal cancer patients, retrospectively. Results: The target volumes delineated with PET/CT were significantly larger than the volumes created by CT (P = 0.043). Dose delivered to 98% of the planning target volume was high in IMRT planning contouring with CT and PET/CT compared with CRT planning, but the difference was …
Pregnancy-Associated Plasma Protein A And Procalcitonin As Markers Of Myocardial Injury In Patients With Acute Coronary Syndrome, Ayşegül Bayir, Hasan Kara, Aysel Kiyici, Bahadir Öztürk, Abdullah Si̇vri̇kaya, Fi̇kret Akyürek
Pregnancy-Associated Plasma Protein A And Procalcitonin As Markers Of Myocardial Injury In Patients With Acute Coronary Syndrome, Ayşegül Bayir, Hasan Kara, Aysel Kiyici, Bahadir Öztürk, Abdullah Si̇vri̇kaya, Fi̇kret Akyürek
Turkish Journal of Medical Sciences
To evaluate pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), procalcitonin, and troponin I levels as diagnostic markers of acute coronary syndrome in patients admitted to the emergency department. Materials and methods: The serum PAPP-A, IMA, procalcitonin, and troponin I levels were measured in 100 patients with acute coronary syndrome admitted to the emergency department and 100 healthy control subjects. Results: Patients with acute coronary syndrome had significantly greater mean serum PAPP-A (patients, 10 ± 10 mIU/L; control subjects, 6 ± 10 mIU/L; P =< 0.001), procalcitonin (patients, 2 ± 10 µg/L; control subjects, 0.4 ± 2 µg/L; P =< 0.001), and troponin I levels (patients, 6 ± 8 µg/L; control subjects, 0.2 ± 0.3 µg/L; P =< 0.001) than control subjects. There was no difference in mean IMA levels between patients and control subjects. There were no significant correlations between PAPP-A levels and IMA, procalcitonin, or troponin I levels in patients with acute coronary syndrome. Conclusion: The PAPP-A, procalcitonin, and troponin I levels were increased in patients with acute coronary syndrome. Therefore, elevated PAPP-A and procalcitonin levels, in addition to troponin I levels, may be useful markers of myocardial injury on admission to the emergency department.
An Alternative Marker Of Low-Density Lipoprotein Cholesterol In Coronary Artery Disease: Non-High-Density Lipoprotein Cholesterol, Müjgan Ercan, Esra Oğuz, Fatma Meri̇ç Yilmaz, Ni̇hal Boğdaycioğlu, Kübranur Ünal, Deni̇z Şahi̇n, Sema Uysal
An Alternative Marker Of Low-Density Lipoprotein Cholesterol In Coronary Artery Disease: Non-High-Density Lipoprotein Cholesterol, Müjgan Ercan, Esra Oğuz, Fatma Meri̇ç Yilmaz, Ni̇hal Boğdaycioğlu, Kübranur Ünal, Deni̇z Şahi̇n, Sema Uysal
Turkish Journal of Medical Sciences
Dyslipidemia is one of the most important risk factors for coronary artery disease (CAD), and low-density lipoprotein cholesterol (LDL-C) is used to measure dyslipidemia. Non-high-density lipoprotein cholesterol (non-HDL-C) seems to be an alternative parameter to LDL-C as it is not influenced by triglyceride (TG) levels. The aim of this study is to compare non-HDL-C and LDL-C levels as risk markers in CAD patients. Materials and methods: One hundred and ten CAD patients and 42 individuals with normal coronary angiography results were included in this study. Patients were divided into 2 groups: TG < 200 mg/dL (n = 75) as group 1 and TG > 200 mg/dL (n = 35) as group 2. …
Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut
Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut
Turkish Journal of Medical Sciences
Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism. Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance …
Assessment Of Nasal Mucociliary Clearance In Anesthetists, Eyüp Horasanli, Aydin Acar, Bünyami̇n Muslu, Meli̇h Çayönü, Murat Çi̇mencan, Serkan Kayabaşi
Assessment Of Nasal Mucociliary Clearance In Anesthetists, Eyüp Horasanli, Aydin Acar, Bünyami̇n Muslu, Meli̇h Çayönü, Murat Çi̇mencan, Serkan Kayabaşi
Turkish Journal of Medical Sciences
To assess mucociliary clearance in anesthetists who were exposed to waste anesthetic gases occupationally. Materials and methods: The first group consisted of 30 anesthetists who had been working at least 2 years. The control group of 30 subjects was selected from hospital staff with no history of occupational exposure to waste anesthetic gases. Mucociliary clearance time was assessed by measuring the saccharine nasal transit time (SNTT). Results: Thirty-six women and 24 men aged between 25 and 60 years were enrolled in the study. There were no differences between the anesthetist and control groups in terms of age, sex, height, or …