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Articles 2611 - 2640 of 4871
Full-Text Articles in Medicine and Health Sciences
Short-Term Effect Of Transcatheter Aortic Valve Implantation On Qt Dispersion, Haci Ahmet Kasapkara, Hüseyi̇n Ayhan, Tahi̇r Durmaz, Telat Keleş, Cenk Sari, Serdal Baştuğ, Cemal Köseoğlu, Bi̇lge Duran Karaduman, Murat Akçay, Ni̇hal Akar Bayram, Emi̇ne Bi̇len, Engi̇n Bozkurt
Short-Term Effect Of Transcatheter Aortic Valve Implantation On Qt Dispersion, Haci Ahmet Kasapkara, Hüseyi̇n Ayhan, Tahi̇r Durmaz, Telat Keleş, Cenk Sari, Serdal Baştuğ, Cemal Köseoğlu, Bi̇lge Duran Karaduman, Murat Akçay, Ni̇hal Akar Bayram, Emi̇ne Bi̇len, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Electrophysiological changes are observed following mechanical stretches due to pressure overload in patients with severe aortic stenosis (AS). The electrical instability occurs after depolarization and dispersion of repolarization. The aim of this study was to evaluate changes in ventricular repolarization following transcatheter aortic valve implantation (TAVI). Materials and methods: The study population included 100 consecutive patients with severe AS that underwent TAVI. Electrocardiography (ECG) was performed at baseline, immediately after TAVI, and 1 week after TAVI. Results: The mean age of the patients was 78.2 ± 7.2 years. Thirty-four (34%) of the patients were male and 66 (66%) were …
Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş
Effects Of Grape Seed Extract On Oxidative Stress And Antioxidant Defensemarkers In Streptozotocin-Induced Diabetic Rats, Muaz Belvi̇ranli, Hakki Gökbel, Ni̇lsel Okudan, Sadik Büyükbaş
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg-1 day-1) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA …
The Expression And Clinical Effects Of Alpha-Methylacyl-Coa Racemase (Amacr/ P504s) As An Immunohistochemical Marker In Malign Pleural Mesothelioma, Sezgi̇ Şahi̇n Duyar, Aydin Yilmaz, Funda Demi̇rağ, Yurdanur Erdoğan, Ülkü Yazici, Jale Karakaya
The Expression And Clinical Effects Of Alpha-Methylacyl-Coa Racemase (Amacr/ P504s) As An Immunohistochemical Marker In Malign Pleural Mesothelioma, Sezgi̇ Şahi̇n Duyar, Aydin Yilmaz, Funda Demi̇rağ, Yurdanur Erdoğan, Ülkü Yazici, Jale Karakaya
Turkish Journal of Medical Sciences
Background/aim: Alpha-methylacyl-CoA racemase (AMACR), an intracellular enzyme involved in lipid metabolism, has emerged as an immunohistochemical marker for many types of cancer. Recent studies about the role of lipid metabolism in pathogenesis of mesothelioma have brought up some positive results. This study was conducted to investigate AMACR expression in the diagnosis of malignant pleural mesothelioma (MPM) and the correlation of this marker with clinical characteristics and survival. Materials and methods: The clinicopathologic characteristics and resection materials of 71 patients were reviewed retrospectively. AMACR expression was evaluated immunohistochemically. The correlations among AMACR expression, clinicopathologic factors, and survival were investigated. Results: AMACR …
Serum Lp-Pla2: As A Novel Viewpoint In Periodontal Treatment Of Hyperlipidaemics, Özlem Fentoğlu, Fatma Yeşi̇m Kirzioğlu, Memduha Tözüm Bulut, Şi̇vge Kurgan, Havva Koçak, Recep Sütcü, Banu Kale Köroğlu, Meral Günhan
Serum Lp-Pla2: As A Novel Viewpoint In Periodontal Treatment Of Hyperlipidaemics, Özlem Fentoğlu, Fatma Yeşi̇m Kirzioğlu, Memduha Tözüm Bulut, Şi̇vge Kurgan, Havva Koçak, Recep Sütcü, Banu Kale Köroğlu, Meral Günhan
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. Materials and methods: The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). Results: At the baseline, …
Central Corneal Thickness In Type Ii Diabetes Mellitus: Is It Relatedto The Severity Of Diabetic Retinopathy?, Okan Toygar, Selçuk Sizmaz, Aysel Peli̇t, Baha Toygar, Özge Yabaş Kiziloğlu, Yonca Akova
Central Corneal Thickness In Type Ii Diabetes Mellitus: Is It Relatedto The Severity Of Diabetic Retinopathy?, Okan Toygar, Selçuk Sizmaz, Aysel Peli̇t, Baha Toygar, Özge Yabaş Kiziloğlu, Yonca Akova
Turkish Journal of Medical Sciences
Background/aim: To compare the central corneal thickness (CCT) of type II diabetes mellitus patients with age- and sex-matched healthy subjects and to determine the association of the severity of diabetic retinopathy and CCT. Materials and methods: Type II diabetes mellitus patients without retinopathy, with nonproliferative retinopathy, and with proliferative retinopathy were organized as the three subgroups of the study group, and an age- and sex-matched control group was formed. All subjects underwent full ophthalmological examination and CCT measurement with ultrasonographic pachymetry. CCT values were compared between diabetic and healthy subjects and between the three diabetic subgroups. Correlation analysis was performed …
Serologic Testing For Celiac Disease In Young People With Elevated Transaminases, Juanli Yuan, Jinyan Gao, Yonghong Yao, Hongbing Chen
Serologic Testing For Celiac Disease In Young People With Elevated Transaminases, Juanli Yuan, Jinyan Gao, Yonghong Yao, Hongbing Chen
Turkish Journal of Medical Sciences
Background/aim: A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated transaminases. Materials and methods: A total of 125 patients with elevated transaminases and 125 healthy individuals as controls with matched age and sex were involved in the study. Serum markers of hepatitis B were determined in patients with elevated transaminases. All …
Evaluation Of The Effect Of Isotretinoin On Salivary Gland Function By Tc-99m Pertechnetate Imaging In Acne Vulgaris Patients, Ebru Örsal, Bedri̇ Seven, Mustafa Teoman Erdem, Erhan Varoğlu, Hati̇ce Farimaz, Ari̇f Kürşad Ayan
Evaluation Of The Effect Of Isotretinoin On Salivary Gland Function By Tc-99m Pertechnetate Imaging In Acne Vulgaris Patients, Ebru Örsal, Bedri̇ Seven, Mustafa Teoman Erdem, Erhan Varoğlu, Hati̇ce Farimaz, Ari̇f Kürşad Ayan
Turkish Journal of Medical Sciences
Background/aim: Isotretinoin is an effective drug utilized in the management of acne vulgaris and is known to cause dry mouth. In this study, we aimed to evaluate this effect of isotretinoin on the salivary gland function in patients with acne vulgaris using technetium-99m (Tc-99m) pertechnetate imaging of the salivary glands. Materials and methods: The study population consisted of 28 patients with acne vulgaris (6 males and 22 females, mean age 20.2 ± 2.3 years), who were treated with isotretinoin for 6 months. We performed radionuclide imaging of the salivary glands pretreatment and at months 3 and 6 of treatment. After …
Burnout In Caregivers Of Patients With Schizophrenia, Ahmet Kokurcan, Ayşe Gül Yilmaz Özpolat, Ali̇ Kemal Göğüş
Burnout In Caregivers Of Patients With Schizophrenia, Ahmet Kokurcan, Ayşe Gül Yilmaz Özpolat, Ali̇ Kemal Göğüş
Turkish Journal of Medical Sciences
Background/aim: To evaluate the burnout of schizophrenia patients' caregivers and to determine the possible relationships between sociodemographic characteristics, symptomatology, perceived social support, and the burnout profile of the caregivers. Materials and methods: Subjects included in the study are 76 schizophrenia patients, diagnosed according to DSM-IV-TR criteria, and their caregivers. A sociodemographic form, the Scale for the Assessment of Positive Symptoms, and the Scale for the Assessment of Negative Symptoms were applied to evaluate the severity of the symptoms. The Maslach Burnout Inventory for Caregivers and the Multidimensional Scale of Perceived Social Support were applied to the caregivers of the patients. …
In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün
In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün
Turkish Journal of Medical Sciences
Background/aim: Currently, the provision of blood products largely depends on walking blood banks and limited amounts of stored blood with short shelf lives. We aimed to compare the efficacy of erythrocyte concentrate (ECs) by pre- and postfreezing in vitro tests. Materials and methods: In our study, 10 ECs were glycerolized, frozen, thawed, and then deglycerolized using the Naval Blood Research Laboratory method. In addition to using the standard tests, ATP and 2,3-DPG levels and the viability of erythrocytes were also determined. Results: The prefreezing mean viability rates of erythrocytes changed from 89.7 ± 13.7% to 98.6 ± 1.8% after thawing …
Comparison Of Local Infiltration Anesthesia And Peripheral Nerve Block:A Randomized Prospective Study In Hand Lacerations, Alp Şener, Ahmet Demi̇rcan, Ayfer Keleş, Fi̇kret Bi̇ldi̇k, Kanber Karakurt
Comparison Of Local Infiltration Anesthesia And Peripheral Nerve Block:A Randomized Prospective Study In Hand Lacerations, Alp Şener, Ahmet Demi̇rcan, Ayfer Keleş, Fi̇kret Bi̇ldi̇k, Kanber Karakurt
Turkish Journal of Medical Sciences
Background/aim: To compare local infiltration anesthesia (LIA) and peripheral nerve block (PNB) in repairing hand lacerations. Materials and methods: This prospective study was designed as a randomized, controlled, unblinded trial. Fifty four patients with hand lacerations were included in the study. While 23 of these patients had LIA, PNB was performed in the remaining 31 patients. Lidocaine hydrochloride 2% and 27 gauge needles were used. Onset time of the anesthesia, response to the injection and suturing procedures, need for additional anesthetic, and patient satisfaction were compared. Results: No significant differences were noted between the groups in terms of response to …
Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi
Comparison Of Endometrial Biopsies Of Fertile Women And Womenwith Repeated Implantation Failure At The Ultrastructural Level, Leyla Bahar, Semra Kahraman, Nazan Eras, Caroline Pirkevi
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to compare the cellular properties of endometrial tissues from fertile patients and patients having at least 3 previous in vitro fertilization failures, during the implantation window. The ultrastructural evaluation of the endometrium in the implantation window may shed light on the complexity of the implantation failure paradigm. Materials and methods: The study involved 23 women, 14 infertile with a clinical diagnosis of repeated implantation failure (RIF) and 9 fertile, defined as the control group. Endometrial samples were examined by transmission electron microscopy (TEM). Results: In the control group, secretory vacuoles and cytoplasmic projections …
Suspension Of Arthroderma And Trichophyton Species In Rpmi-1640medium Provided Long-Term Viability At Room Temperature, Çağri Ergi̇n, Mehmet Maci̇t İlki̇t
Suspension Of Arthroderma And Trichophyton Species In Rpmi-1640medium Provided Long-Term Viability At Room Temperature, Çağri Ergi̇n, Mehmet Maci̇t İlki̇t
Turkish Journal of Medical Sciences
No abstract provided.
Sexuality And Sexual Dysfunction In Spinal Cord-Injured Men In Turkey, Ramazan Yavuz Akman, Evri̇m Coşkun Çeli̇k, Meti̇n Karataş
Sexuality And Sexual Dysfunction In Spinal Cord-Injured Men In Turkey, Ramazan Yavuz Akman, Evri̇m Coşkun Çeli̇k, Meti̇n Karataş
Turkish Journal of Medical Sciences
Background/aim: To provide a comprehensive evaluation of sexual function and dysfunction in spinal cord-injured men based on self-reports of patients. Materials and methods: Forty-seven spinal cord-injured men who completed the spinal shock and rehabilitation period were included. Patients were asked to complete a questionnaire developed to assess social status, sexual activities, abilities, and sexuality education after injury. Neurologic levels of patients were classified according to American Spinal Cord Injury Association protocol. Erectile function was evaluated by International Index of Erectile Function-5 (IIEF-5) questionnaire. Results: Patients were aged between 20 and 62 years (mean: 35.2). Twenty-eight patients had T10 and above, …
Determining The Health Beliefs And Breast Cancer Fear Levels Ofwomen Regarding Mammography, Fatma Ersi̇n, Fatma Gözükara, Peri̇han Polat, Gözde Erçeti̇n, Mehmet Ekrem Bozkurt
Determining The Health Beliefs And Breast Cancer Fear Levels Ofwomen Regarding Mammography, Fatma Ersi̇n, Fatma Gözükara, Peri̇han Polat, Gözde Erçeti̇n, Mehmet Ekrem Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Women's fears and health beliefs impact their participation in early breast cancer diagnosis approaches. This study was conducted to determine the health beliefs and fear levels of women older than 50 regarding mammography. Materials and methods: A cross-sectional study was conducted in Turkey. The study cohort consisted of 300 women selected by cluster sampling who agreed to participate in the study. A health belief model scale and breast cancer fear scale were used in data collection. Descriptive statistics, t-test, chi-square test, and correlation analysis were used in the data analysis. Results: Participants had an age average of 59.88 ± …
Is There A Role Of Interstitial Cells Of Cajal And Mast Cells And Eosinophilsin Appendicitis In Children?, Esra Karakuş, Müjdem Nur Azili, Bi̇lge Karabulut, Gülşah Bayram Kabaçam, Resul Karakuş
Is There A Role Of Interstitial Cells Of Cajal And Mast Cells And Eosinophilsin Appendicitis In Children?, Esra Karakuş, Müjdem Nur Azili, Bi̇lge Karabulut, Gülşah Bayram Kabaçam, Resul Karakuş
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to compare the distribution of interstitial Cajal cells, eosinophils, and mast cells in normal and inflamed appendices, and to evaluate the correlation of presence of these cells with severity of inflammation in appendicitis. Materials and methods: The appendicitis group (n = 30) was divided further into three groups according to the macroscopic description and the histological findings. Ten normal appendices served as controls. Tissue samples were processed for routine histological examination. Additionally, all sections were immunohistochemically stained with CD117 and mast cell tryptase antibodies. Results: When specimens were compared in terms of Cajal …
Cardiac Factors Affecting The Success Of Vardenafil In Erectile Dysfunction, Kürşad Zengi̇n, Hüseyi̇n Ede, Serhat Tanik, Sebahatti̇n Albayrak, Savaş Sarikaya, Ali̇riza Erbay, Muhammet Abdurrahi̇m İmamoğlu, Mesut Gürdal
Cardiac Factors Affecting The Success Of Vardenafil In Erectile Dysfunction, Kürşad Zengi̇n, Hüseyi̇n Ede, Serhat Tanik, Sebahatti̇n Albayrak, Savaş Sarikaya, Ali̇riza Erbay, Muhammet Abdurrahi̇m İmamoğlu, Mesut Gürdal
Turkish Journal of Medical Sciences
Background/aim: To evaluate the predictability of vardenafil success in patients with erectile dysfunction (ED) by using cardiological tests. Materials and methods: Patients diagnosed with ED who did not benefit from lifestyle changes (n = 68) were evaluated with an abridged 5-item version of the International Index of Erectile Function (IIEF-5). The pretreatment and posttreatment IIEF-5 scores were compared with pretreatment data obtained from cardiological examinations. Results: When pretreatment scores were compared with test parameters, mitral flow E/A ratio and tissue Doppler imaging (TDI) E?/A?, exercise test duration, exercise capacity in MET, and percentage of maximum heart rate were found to …
Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer
Effects Of Turkish Propolis On Expression Of Hogg-1 And Neil-1, İbrahi̇m Turan, Orhan Değer, Yüksel Ali̇yazicioğlu, Seli̇m Demi̇r, Kağan Kilinç, Ayşegül Sümer
Turkish Journal of Medical Sciences
Background/aim: Propolis is a bee product with antioxidative, antimutagenic, and other beneficial properties, and it is used as a natural drug. It is rich in polyphenolic compounds. Its composition varies depending on the particular geographical region. Oxidative stress is caused by an imbalanced free radical production and antioxidant system. The effects of flavonoids on the expression of DNA repair enzymes have been examined previously; however, no study has investigated the effects of propolis. This study investigated the effects of ethanolic extracts of Turkish propolis (EEP) on the expression of DNA repair enzymes. Materials and methods: The effects of EEP and …
Evaluation Of Gcf Mmp-1, Mmp-8, Tgf-Ss1, Pdgf-Ab, And Vegf Levels In Periodontally Healthy Smokers, Gülni̇hal Eren, Hati̇ce Oya Türkoğlu, Hari̇ka Atmaca, Fatma Gül Ati̇lla
Evaluation Of Gcf Mmp-1, Mmp-8, Tgf-Ss1, Pdgf-Ab, And Vegf Levels In Periodontally Healthy Smokers, Gülni̇hal Eren, Hati̇ce Oya Türkoğlu, Hari̇ka Atmaca, Fatma Gül Ati̇lla
Turkish Journal of Medical Sciences
Background/aim: The effect of smoking on inflammatory biomarkers in gingival crevicular fluid (GCF) is well established in the presence of periodontal inflammation. However, it is not clear if smoking has an influence on matrix metalloproteinase (MMP) and growth factor levels in the GCF of periodontally healthy subjects. The aim of this study was to investigate GCF levels of MMP-1, MMP-8, transforming growth factor (TGF)-ß1, platelet-derived growth factor (PDGF)-AB, and vascular endothelial growth factor (VEGF) in smoking versus nonsmoking periodontally healthy subjects. Materials and methods: Thirty-two periodontally healthy subjects were included in this study. Probing depths, bleeding on probing, and plaque …
A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi
A Study Of The Effect Of Bacillus Thuringiensis Serotype H14 (Subspecies Israelensis)Delta Endotoxin On Musca Larva, Mohammad Reza Mehrabi, Laya Zoghimofrad, Mahboubeh Mazinani, Azim Akbarzadeh, Amirabbas Rahimi
Turkish Journal of Medical Sciences
Background/aim: House flies (Musca domestica) are of major public health concern in areas with poor sanitation and hygiene conditions. Biological control through the use of parasitoids and pathogens is one of the alternatives to the use of chemical pesticides for control of insects of public health importance. Materials and methods: The effects of the delta endotoxin of Bacillus thuringiensis on house fly larval mortality were studied. Gel filtration and SDS-PAGE methods were used for separation and purification of proteins. Delta endotoxin was incubated with larvae in concentrations of 0.43 mg/mL and 0.27 mg/mL in bioassay tests. Results: The results of …
The Effect Of Swimming And Type Of Stroke On Bone Metabolism In Competitiveadolescent Swimmers: A Pilot Study, Si̇nem Akgül, Nuray Kanbur, Şükrü Alpan Ci̇nemre, Erdem Karabulut, Orhan Derman
The Effect Of Swimming And Type Of Stroke On Bone Metabolism In Competitiveadolescent Swimmers: A Pilot Study, Si̇nem Akgül, Nuray Kanbur, Şükrü Alpan Ci̇nemre, Erdem Karabulut, Orhan Derman
Turkish Journal of Medical Sciences
Background/aim: Physical activity plays a key role in increasing and preserving bone mineral density (BMD). Effects on bone development associated with various nonweight-bearing sporting activities, such as swimming, are controversial. Different strokes used in swimming may also present as another factor. The aim of this study was to evaluate the effect of swimming and type of stroke on BMD in competitive adolescent athletes. Materials and methods: Seventy-nine swimmers between the ages of 10 and 21 years participated in this study. BMD was measured with dual-energy X-ray absorptiometry at the lumbar vertebrae and left proximal femur. Daily calorie intake and calcium …
A Case-Control Study: Evaluation Of Vitamin D Metabolism In Patients With Vitiligo, Zennure Takci, Özlem Teki̇n, Derun Taner Ertuğrul, Ayşe Serap Karadağ, Kadi̇r Okhan Akin
A Case-Control Study: Evaluation Of Vitamin D Metabolism In Patients With Vitiligo, Zennure Takci, Özlem Teki̇n, Derun Taner Ertuğrul, Ayşe Serap Karadağ, Kadi̇r Okhan Akin
Turkish Journal of Medical Sciences
Background/aim: Reduced vitamin D is considered as one of the environmental factors that can increase the prevalence of certain autoimmune diseases. This study aimed to assess vitamin D metabolism in patients with vitiligo. Materials and methods: A prospective case-control study was conducted on 44 consecutive patients with vitiligo vulgaris and 43 healthy controls. Their plasma 25-hydroxyvitamin D (25(OH)D), parathormone (PTH), calcium, magnesium, and phosphate levels were measured. Results: There was no significant difference in the mean age, sex and Fitzpatrick skin phototype between the patient and control groups (P > 0.05). The plasma levels of 25(OH)D and calcium were signi?cantly decreased …
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Effects Of Melatonin And Theanine Administration On Pentylenetetrazole-Inducedseizures And Brain Tissue Oxidative Damage In Ovariectomized Rats, Shadi Choopankareh, Farzaneh Vafaee, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Reza Salarinia, Leila Zarepoor, Mahmoud Hosseini
Turkish Journal of Medical Sciences
Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods: The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVX-PTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1-4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results: The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ …
Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Hepatoprotective And Antioxidant Effects Of Lycopene In Acute Cholestasis, Mehmet Tokaç, Sevtap Aydin, Gökçe Taner, Alper Bi̇lal Özkardeş, Mi̇ne Yavuz Taşlipinar, Mehmet Doğan, Hali̇t Zi̇ya Dündar, Mehmet Kiliç, Ari̇f Ahmet Başaran, Ayşe Nurşen Başaran
Turkish Journal of Medical Sciences
Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL …
Determination Of Apoptosis And Cell Cycle Modulators (P16, P21, P27, P53, Bcl-2,Bax, Bcl-Xl, And Cyclin D1) In Thyroid Follicular Carcinoma, Follicular Adenoma,And Adenomatous Nodules Via A Tissue Microarray Method, Peyker Temi̇z, Gi̇zem Akkaş, Nalan Neşe, Fazi̇let Uğur Duman, Cansu Karakaş, Yamaç Erhan
Determination Of Apoptosis And Cell Cycle Modulators (P16, P21, P27, P53, Bcl-2,Bax, Bcl-Xl, And Cyclin D1) In Thyroid Follicular Carcinoma, Follicular Adenoma,And Adenomatous Nodules Via A Tissue Microarray Method, Peyker Temi̇z, Gi̇zem Akkaş, Nalan Neşe, Fazi̇let Uğur Duman, Cansu Karakaş, Yamaç Erhan
Turkish Journal of Medical Sciences
Background/aim: To identify the role of gene products associated with apoptosis and cell cycle in the pathogenesis of thyroid follicular neoplasm. Materials and methods: Thirty follicular adenomas (FAs), 16 follicular carcinomas (FCs), and 20 adenomatous nodules (ANs) were investigated with immunohistochemical staining of p16, p21, p27, p53, Bcl-2, Bax, Bcl-xL, and cyclin D1 via a tissue microarray method. Results: Bcl-2 showed a significant difference between the benign groups (AN and FA) and the malignant group (FC). Bax was significantly higher in the FC group. p53 was lowest in the AN group and highest in the FC group with significant differences …
Healthy Subjects' Knowledge Of Surgical Complications: A Hospital-Based Survey, Abdussamed Yalçin, Ersi̇n Gürkan Dumlu, Mehmet Tokaç, Ömer Parlak, Levent Öztürk, Mehmet Kiliç
Healthy Subjects' Knowledge Of Surgical Complications: A Hospital-Based Survey, Abdussamed Yalçin, Ersi̇n Gürkan Dumlu, Mehmet Tokaç, Ömer Parlak, Levent Öztürk, Mehmet Kiliç
Turkish Journal of Medical Sciences
Background/aim: There is an ongoing debate about how much a patient should know about serious or frequently occurring risks of their surgery. In this study, we evaluated healthy subjects' perspectives on knowledge of serious surgical complications. Materials and methods: Three hundred and thirty healthy subjects (151 women, 179 men; mean age: 43.6 ± 17.3 years) were surveyed with the study questionnaire. Social profile, surgical history of the healthy subjects, and presence of a relative while giving preoperative consent were assessed. Results: Only 23.5% (39/166) of the subjects were informed about all the potential complications of their previous surgical operation and …
Smoking Cessation And The Effect Of Nicotine Dependence Onrelapse Rate In İzmir, Turkey, Özlem Pekel, Gül Ergör, Türkan Günay, Hakan Baydur, Beri̇l Choussein, Refi̇k Budak, Si̇nem Doğanay
Smoking Cessation And The Effect Of Nicotine Dependence Onrelapse Rate In İzmir, Turkey, Özlem Pekel, Gül Ergör, Türkan Günay, Hakan Baydur, Beri̇l Choussein, Refi̇k Budak, Si̇nem Doğanay
Turkish Journal of Medical Sciences
Background/aim: Smoking is the leading preventable cause of death in the world. There is growing evidence of the need for community-based programs on smoking cessation. The main purpose of this study is to establish the rate of smoking cessation and restarting in 1 year at the Balçova Smoking Cessation Center. Materials and methods: This is a prospective study with a study group of 359 individuals who quit smoking at the Balçova Smoking Cessation Center for at least 4 weeks between October 2009 and April 2010. The outcomes of the study were 1-year cessation rate and relapse rate. Individuals who reported …
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to determine the epidemiological and clinical characteristics of patients diagnosed with tularemia and the effectiveness of the administered treatments. Materials and methods: Patients treated in our hospital between January 2009 and March 2011 and diagnosed with tularemia were evaluated retrospectively. Patients' epidemiological and clinical characteristics, administered treatments, and posttreatment findings were recorded on patient monitoring forms. Results: At anamnesis, 29% of patients used water from wells and 71% used water from the network supply; moreover, 48.4% had a history of contact with animals and 87.1% a history of lethargy. At physical examination, 96.8% …
Vkorc1 And Cyp2c9 Genotypic Data-Based Dose Prediction Alone Does Not Accurately Predict Warfarin Dose Requirements In Some Malaysian Patients, Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Vkorc1 And Cyp2c9 Genotypic Data-Based Dose Prediction Alone Does Not Accurately Predict Warfarin Dose Requirements In Some Malaysian Patients, Yung An Chua, Wan Zaidah Abdullah, Zurkurnai Yusof, Siew Hua Gan
Turkish Journal of Medical Sciences
Background/aim: VKORC1 and CYP2C9 genetic polymorphisms may not accurately predict warfarin dose requirements. We evaluated an existing warfarin dosing algorithm developed for Malaysian patients that was based only on VKORC1 and CYP2C9 genes. Materials and methods: Five Malay patients receiving warfarin maintenance therapy were investigated for their CYP2C9*2, CYP2C9*3, and VKORC1-1639G>A genotypes and their vitamin K-dependent (VKD) clotting factor activities. The records of their daily warfarin doses and international normalized ratio (INR) 2 years prior to and after the measurement of VKD clotting factors activities were acquired. The mean warfarin doses were compared with predicted warfarin doses calculated from …
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Turkish Journal of Medical Sciences
Background/aim: Biofilm on urinary catheters results in persistent infections that are resistant to antibiotics. In this study, phytochemicals were assessed as alternative antimicrobials in preventing and inactivating E. coli biofilm on urinary catheters. Materials and methods: Biofilm prevention was tested using catheter fragments inoculated with E. coli and treated with trans-cinnamaldehyde, p-coumaric, and ferulic acids (0%, 0.1%, 0.25%, and 0.5%) for 0, 1, 3, and 5 days. Inactivation of E. coli biofilm with the same agents at concentrations of 0%, 1%, 1.25%, or 1.5% used for 0, 1, 3, or 5 days was also evaluated. Results: All used concentrations of …
Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇
Periocular Changes In Topical Bimatoprost And Latanoprost Use, Meli̇sa Zi̇şan Karslioğlu, Melek Banu Hoşal, Oya Tekeli̇
Turkish Journal of Medical Sciences
Background/aim: To evaluate the periocular changes due to topical bimatoprost and latanoprost use and to investigate their effects on the lacrimal drainage system. Materials and methods: All participants (69 eyes of 43 patients, 52 eyes of 26 controls) were classified into three groups: bimatoprost (0.03%) users, latanoprost (0.005%) users, and healthy controls. Each patient was examined before prostaglandin therapy, and then at the first, third, sixth, and twelfth month of therapy. Palpebral fissure height, upper eyelid crease, and levator function were measured, and lacrimal system drainage irrigation was performed. Periocular hyperpigmentation and upper eyelid sulcus were also examined. Results: No …