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Articles 2221 - 2250 of 4871
Full-Text Articles in Medicine and Health Sciences
Frequencies And Distributions Of Sex Chromosome Abnormalities In Females With The Turner Phenotype: A Long-Term Retrospective Study In The Southern Region Of Turkey, Ni̇lgün Tanriverdi̇, Osman Demi̇rhan, Di̇lara Süleymanova Karahan, Ayfer Pazarbaşi
Frequencies And Distributions Of Sex Chromosome Abnormalities In Females With The Turner Phenotype: A Long-Term Retrospective Study In The Southern Region Of Turkey, Ni̇lgün Tanriverdi̇, Osman Demi̇rhan, Di̇lara Süleymanova Karahan, Ayfer Pazarbaşi
Turkish Journal of Medical Sciences
Background/aim: The genetic background of Turner syndrome (TS) is highly variable. The correlation between genotype and phenotype is not yet well understood. The aim of this study was to describe the frequencies and distributions of Turner karyotypes and to discuss the phenotype/genotype relation in a very large group of individuals with TS. Materials and methods: The karyotype results of 248 female participants were evaluated retrospectively.Results: Of 248 females with the Turner phenotype, 14.5% had normal karyotypes and 85.5% had Turner karyotypes. About 72.2% of the abnormalities were numerical aberrations and 27.8% were structural aberrations. The most frequent karyotype was monosomy …
Prevalence And Risk Factors For Helicobacter Pylori Infection In Southwest China: A Study Of Health Examination Participants Based On 13c-Urea Breath Test, Jie Liu, Yonghong Wang, Qinghua Zhao, Rong Luo, Mingzhao Xiao, Mingjun Zhang, Weibo Xie
Prevalence And Risk Factors For Helicobacter Pylori Infection In Southwest China: A Study Of Health Examination Participants Based On 13c-Urea Breath Test, Jie Liu, Yonghong Wang, Qinghua Zhao, Rong Luo, Mingzhao Xiao, Mingjun Zhang, Weibo Xie
Turkish Journal of Medical Sciences
Background/aim: Helicobacter pylori (H. pylori) has a high prevalence in developing countries. We aimed to investigate the current prevalence of H. pylori, as well as its potential serum risk factors, in a population from southwest China.Materials and methods: This cross-sectional study included 10,912 subjects who received medical examinations at the First Affiliated Hospital of Chongqing Medical University in 2014. Data regarding physical examinations and biochemical measurements were collected, and H. pylori infection was diagnosed with a 13C-urea breath test. Logistic regression was conducted to identify the risk factors for H. pylori infection.Results: The infection rate of H. pylori was 34.4% …
Detection And Molecular Characterisation Of Adenovirus In Children Under 5 Years Old With Diarrhoea, Meryem Çolak, Gülendam Bozdayi, Ayli̇n Altay, Zahi̇de Yalaki̇, Kamruddi̇n Ahmed, Seçi̇l Özkan
Detection And Molecular Characterisation Of Adenovirus In Children Under 5 Years Old With Diarrhoea, Meryem Çolak, Gülendam Bozdayi, Ayli̇n Altay, Zahi̇de Yalaki̇, Kamruddi̇n Ahmed, Seçi̇l Özkan
Turkish Journal of Medical Sciences
Background/aim: To determine the frequency, genotype distribution, and genetic relatedness of adenoviruses in children under 5 years old with diarrhoea and to investigate their distribution according to clinical findings, age, months, and seasons. Materials and methods: Stool samples were collected from 180 children with acute gastroenteritis who presented from July 2007 through June 2011 at the Ankara Training and Education Hospital. Stool samples were analysed by immune chromatographic test (ICT), enzyme immunoassay (EIA), and polymerase chain reaction (PCR). All adenovirus types were determined by nucleotide sequence analysis. A phylogenetic tree was constructed by Mega 6.0 using the neighbour-joining method. Results: …
Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran
Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran
Turkish Journal of Medical Sciences
Background/aim: Irrational drug use is a common problem. This study aimed to evaluate patients' knowledge and habits concerning drug use, and compare them in terms of some sociodemographic characteristics. Materials and methods: A face-to-face questionnaire was given to outpatients from family healthcare centres (FHCs) and state hospitals (SHs) in 12 provinces in Turkey during May 2010. A total of 4470 patients (FHCs: 2209; SHs: 2261) responded to the questionnaire (response rate: 93.1%). Results: Getting prescriptions without a physical examination was common (second place in FHCs; third place in SHs); 51.0% stated that they wanted physicians to prescribe drugs that they …
Effects Of Whole Blood Viscosity And Plasma Nox On Cardiac Function And Cerebral Blood Flow In Children With Chronic Kidney Disease, Necla Buyan, Meltem Akçaboy, Tayfun Göktaş, Serdar Kula, Bi̇jen Nazliel, Ni̇lgün Çakar, Nermi̇n Uncu, Bülent Çeli̇k, Deni̇z Erbaş
Effects Of Whole Blood Viscosity And Plasma Nox On Cardiac Function And Cerebral Blood Flow In Children With Chronic Kidney Disease, Necla Buyan, Meltem Akçaboy, Tayfun Göktaş, Serdar Kula, Bi̇jen Nazliel, Ni̇lgün Çakar, Nermi̇n Uncu, Bülent Çeli̇k, Deni̇z Erbaş
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to investigate the effects of whole blood viscosity and plasma nitric oxide on cerebral and cardiovascular risks associated with chronic kidney disease. Materials and methods: The study group consisted of 40 pediatric patients and 21 healthy control subjects. Hematologic and biochemical variables, viscosity and plasma nitric oxide levels, echocardiographic findings, and middle cerebral artery blood flow velocity were examined. Results: Viscosity values of patients were significantly lower than those of the control group. Lower values of hematocrit, total protein, and albumin and higher values of ferritin in all patient groups resulted in significantly …
Multiplex Pcr Detection Of Problematic Pathogens Of Clinically Heterogeneous Bacterial Vaginosis In Bulgarian Women, Konstantsa Tosheva-Daskalova, Tanya Vasileva Strateva, Ivan Gergov Mitov, Raina Tzvetanova Gergova
Multiplex Pcr Detection Of Problematic Pathogens Of Clinically Heterogeneous Bacterial Vaginosis In Bulgarian Women, Konstantsa Tosheva-Daskalova, Tanya Vasileva Strateva, Ivan Gergov Mitov, Raina Tzvetanova Gergova
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the correlation between the prevalence of problematic pathogens and the clinical status of women with bacterial vaginosis (BV). Materials and methods: Gardnerella vaginalis, Atopobium vaginae, and Mobiluncus spp. were detected using a multiplex PCR assay, and their role in the infection of Bulgarian women with clinically heterogeneous BV was evaluated. Results: The predominant BV-associated pathogen identified was G. vaginalis with an incidence of 98.39%, followed by A. vaginae (68.05%) and Mobiluncus spp. at 17.01%. The coexistence of A. vaginae and G. vaginalis was more common in women with discharge (in 72.04%) and in patients …
Analysis Of Recurrent Urethral Strictures Due To Iatrogenic Urethral Trauma, Fuat Kizilay, Adnan Şi̇mşi̇r, Mehmet Ceyhun Özyurt
Analysis Of Recurrent Urethral Strictures Due To Iatrogenic Urethral Trauma, Fuat Kizilay, Adnan Şi̇mşi̇r, Mehmet Ceyhun Özyurt
Turkish Journal of Medical Sciences
Background/aim: We aimed to analyze the effects of stricture location, etiology, age, and catheterization time on recurrence rate and recurrence time in patients who underwent direct vision internal urethrotomy (DVIU) for urethral strictures. Materials and methods: Patients were divided into three groups according to the location of the stricture: penile urethra, membranous urethra, and prostatic urethra strictures. Patients were also divided into three groups according to etiologic factors: strictures secondary to endoscopic procedures, urethral catheterization, and open or radical prostatectomy (anastomotic strictures were included in this group). Patients were also divided into three groups according to catheterization time: 5-7 days. …
Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam
Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam
Turkish Journal of Medical Sciences
Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively. The incidence of proven/probable IFI was 6.7%. The incidence of IFI among patients who received prophylaxis was significantly higher than among those who did not receive it (11.3% vs. 4.6%, P = 0.005). There …
The Relationship Between The Degree Of Skin Fibrosis By Sonoelastography And The Degree Of Pulmonary Involvement In Scleroderma, Songül Çi̇ldağ, Mehmet Burak Çi̇ldağ
The Relationship Between The Degree Of Skin Fibrosis By Sonoelastography And The Degree Of Pulmonary Involvement In Scleroderma, Songül Çi̇ldağ, Mehmet Burak Çi̇ldağ
Turkish Journal of Medical Sciences
Background/aim: This study aimed to assess the relationship between skin fibrosis as determined by sonoelastography and the degree of pulmonary involvement as determined by high-resolution computed tomography (HRCT) in patients with diffuse cutaneous systemic sclerosis (dcSSc).Materials and methods: This prospective study included 40 patients with dcSSc. All patients with HRCT scans underwent conventional ultrasonography and sonoelastography to determine skin thickness and degree of fibrosis. The degree of fibrosis was classified according to color-scale sonoelastography. The degree of pulmonary involvement was classified according to HRCT grading groups. The relationship between skin fibrosis and pulmonary involvement was investigated.Results: There was a statistically …
The Histopathological And Stereological Assessment Of The Effect Of Topically Administered Leptin On Cerebral Vasospasm In An Experimental Subarachnoid Hemorrhage Model, Cem Demi̇rel, Cengi̇z Çokluk, Abdurrahman Aksoy, Kerameddi̇n Aydin, Mehmet Emi̇n Önger, Eni̇s Kuruoğlu, Abdullah Hi̇lmi̇ Marangoz, Ömür Gülsüm Deni̇z, Süleyman Kaplan
The Histopathological And Stereological Assessment Of The Effect Of Topically Administered Leptin On Cerebral Vasospasm In An Experimental Subarachnoid Hemorrhage Model, Cem Demi̇rel, Cengi̇z Çokluk, Abdurrahman Aksoy, Kerameddi̇n Aydin, Mehmet Emi̇n Önger, Eni̇s Kuruoğlu, Abdullah Hi̇lmi̇ Marangoz, Ömür Gülsüm Deni̇z, Süleyman Kaplan
Turkish Journal of Medical Sciences
Background/aim: Cerebral vasospasm is a term that refers to prolonged, slowly progressing but reversible pathological narrowing of cerebral arteries occurring several days after subarachnoid hemorrhage (SAH), usually accompanied by a decrease in perfusion distal to the affected artery. Leptin is an endogenous polypeptide hormone that can be carried freely and bound to protein in the blood. Materials and methods: We investigated the superiority of topical application of leptin that may make a contribution to the development of new treatment modalities for unconscious patients in brain injury intensive care units and its preventive effect, which is considered to have multifactorial pathogenesis …
Effects Of Valproic Acid On Sympathetic Activity And Left Ventricularmyocardial Remodelling In Rats During Pressure Overload, Yang Liu, Siyu Li, Zhigang Zhang, Zhanjun Lv, Huijie Jiang, Xiao Tan, Fengquan Liu
Effects Of Valproic Acid On Sympathetic Activity And Left Ventricularmyocardial Remodelling In Rats During Pressure Overload, Yang Liu, Siyu Li, Zhigang Zhang, Zhanjun Lv, Huijie Jiang, Xiao Tan, Fengquan Liu
Turkish Journal of Medical Sciences
Background/aim: Pressure overload induces cardiac remodelling and results in heart failure. Enhanced sympathetic outflow participates in the development of cardiac remodelling for the duration of pressure overload as an independent factor. Valproic acid has recently been shown to reduce neuronal injury and have antiinflammatory and antiapoptotic effects as a histone deacetylase inhibitor. We speculate that the drug plays a specific role in alleviating cardiac remodelling by inhibiting sympathetic activity. Materials and methods: Surgery of partial abdominal aortic constriction was performed on male Sprague-Dawley rats. After 4 weeks, animal models of pressure overload were validated and then valproic acid (300 mg/kg) …
Do Preoperative Oral Carbohydrates Improve Postoperative Outcomesin Patients Undergoing Coronary Artery Bypass Grafts?, Ömer Faruk Şavluk, Mehmet Ali̇ Kuşcu, Füsun Güzelmeri̇ç, Mustafa Emre Gürcü, Atakan Erkilinç, Deni̇z Çevi̇rme, Hali̇de Oğuş, Tuncer Koçak
Do Preoperative Oral Carbohydrates Improve Postoperative Outcomesin Patients Undergoing Coronary Artery Bypass Grafts?, Ömer Faruk Şavluk, Mehmet Ali̇ Kuşcu, Füsun Güzelmeri̇ç, Mustafa Emre Gürcü, Atakan Erkilinç, Deni̇z Çevi̇rme, Hali̇de Oğuş, Tuncer Koçak
Turkish Journal of Medical Sciences
Background/aim: The aim of this prospective study was to determine whether the preoperative oral intake of carbohydrate-rich drinks by patients undergoing a coronary artery bypass graft attenuates postoperative insulin requirements, improves postoperative patient discomfort, provides inotropic support, shortens the length of the ICU stay, and shortens the duration of postoperative mechanical ventilation. Materials and methods: This randomized prospective clinical study included 152 patients with coronary artery disease who were divided into 4 groups. Carbohydrates were administered to 3 groups at different hours and doses before operation. The fourth group had an 8-h preoperative fasting period. The inotropic and vasopressor requirements, …
Parathyroid Hormone In Washout Fluid Seems To Be Superior To Cytology For Localization Of The Lesion In Mibi-Negative Patients With Primary Hyperparathyroidism, Güven Bariş Cansu, Bengür Taşkiran, Hayretti̇n Di̇zen, Betül Peker Cengi̇z
Parathyroid Hormone In Washout Fluid Seems To Be Superior To Cytology For Localization Of The Lesion In Mibi-Negative Patients With Primary Hyperparathyroidism, Güven Bariş Cansu, Bengür Taşkiran, Hayretti̇n Di̇zen, Betül Peker Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: Primary hyperparathyroidism (PHPT) is characterized by increased calcium (Ca) and parathyroid hormone (PTH) levels. Surgical removal of the culprit hyperfunctioning parathyroid gland is the preferred treatment. In this study, we aimed to determine whether PTH-washout or cytological examination of suspicious lesions was superior in MIBI-negative patients diagnosed with PHPT.Materials and methods: We retrospectively evaluated the medical records of 98 patients diagnosed with PHPT. Seventy-six patients who had positive parathyroid scintigraphy and who did not undergo parathyroidectomy in our center due to various reasons were excluded. We evaluated the remaining 22 patients with negative scintigraphy. Medical records including PTH levels …
Emergency Coronary Bypass Surgery In Patients Under The Influence Of Dualantiplatelet Therapy: Effects Of Tranexamic Acid And Desmopressin Acetate, Gökalp Altun, Doğuş Hemşi̇nli̇, Zerri̇n Pulathan, Ali̇ Ci̇velek
Emergency Coronary Bypass Surgery In Patients Under The Influence Of Dualantiplatelet Therapy: Effects Of Tranexamic Acid And Desmopressin Acetate, Gökalp Altun, Doğuş Hemşi̇nli̇, Zerri̇n Pulathan, Ali̇ Ci̇velek
Turkish Journal of Medical Sciences
Background/aim: Bleeding in patients undergoing coronary artery bypass grafting (CABG) while using dual antiplatelet therapy (DAPT) is a cause of significant morbidity and mortality. The aim of this study is to examine the perioperative hemostatic effects of tranexamic acid (TnX-A) and desmopressin acetate (Des) in these patients. Materials and methods: This clinical study was planned in a prospective and randomized manner. Fifty-four patients were enrolled and classified into 4 different groups. They were compared in terms of various bleeding and transfusion parameters.Results: No significant differences were observed between the groups in pre/intraoperative data apart from closure times. Plasmin/α-2 antiplasmin complex …
Morphometric Analysis Of The Foramen Magnum Using Cone Beam Computed Tomography, Gülsün Akay, Kahraman Güngör, İlkay Peker
Morphometric Analysis Of The Foramen Magnum Using Cone Beam Computed Tomography, Gülsün Akay, Kahraman Güngör, İlkay Peker
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to perform morphometric analysis of the foramen magnum (FM) using cone-beam computed tomography (CBCT). Materials and methods: This study included CBCT images of 190 individuals (88 males and 102 females). The sagittal and transverse diameters and circumference of the FM were measured. The shape of FM was classified as round, hexagonal, oval, egg-shaped, tetragonal, pentagonal, irregular A, and irregular B. The data were statistically analyzed with chi-square and t-tests to assess the level of significance for sex and age. Results: The means of its sagittal and transverse diameters and also circumference were higher …
Evaluation Of The Effects Of Montelukast, Mometasone Furoate, And Combined Therapyon Adenoid Size: A Randomized, Prospective, Clinical Trial With Objective Data, Bi̇rgül Tuhani̇oğlu, Sanem Okşan Erkan
Evaluation Of The Effects Of Montelukast, Mometasone Furoate, And Combined Therapyon Adenoid Size: A Randomized, Prospective, Clinical Trial With Objective Data, Bi̇rgül Tuhani̇oğlu, Sanem Okşan Erkan
Turkish Journal of Medical Sciences
Background/aim: The incidence of adenoid hypertrophy is 2%-3% in children. Adenoidectomy is a commonly performed procedure in children that may cause complications such as early or late bleeding (4%-5%), recurrence of adenoid tissue (10%-20%), and postoperative respiratory problems (27%). Therefore, medical therapy alternatives to adenoidectomy are important and must be tried before surgery. In this study, we investigated the efficacy of mometasone furoate, montelukast, and a combination of these drugs in pediatric patients with adenoid hypertrophy who were scheduled for reduction with medical therapy after not being recommended for surgery.Materials and methods: The study included 120 children with adenoid hypertrophy …
Reliability And Validity Of The Bladder And Bowel Dysfunction Questionnaireamong Turkish Children, Fatma Kaya Narter, Fati̇h Tarhan, Kami̇l Fehmi̇ Narter, Kubilay Sabuncu, Rabi̇a Alay Eser, Yasemi̇n Akin, Pinar Ay
Reliability And Validity Of The Bladder And Bowel Dysfunction Questionnaireamong Turkish Children, Fatma Kaya Narter, Fati̇h Tarhan, Kami̇l Fehmi̇ Narter, Kubilay Sabuncu, Rabi̇a Alay Eser, Yasemi̇n Akin, Pinar Ay
Turkish Journal of Medical Sciences
Background/aim: We developed a Turkish version of the Bladder and Bowel Dysfunction Questionnaire (BBDQ) and evaluated its psychometric properties among Turkish pediatric patients.Materials and methods: The BBDQ was translated into Turkish and then it was back-translated into English. A total of 193 patients were asked to complete the Turkish version of the BBDQ as well as the Dysfunctional Voiding and Incontinence Scoring System (DVISS). In addition, 39 children completed the same questionnaires twice at 2-week intervals for test/retest evaluation.Results: Cronbach's alpha coefficient of the BBDQ was 0.727. Reliability of the test/retest was 0.759 (P < 0.001). Area under the curve of the receiver operating characteristic plot was 0.765. There were statistically significant differences in BBDQ scores between the controls and patients (P < 0.001). Analysis demonstrated moderate convergent validity against the DVISS (r: 0.78, r2: 0.601, P < 0.0001).Conclusion: The Turkish version of the BBDQ is a reliable and valid instrument for Turkish pediatric patients with bladder and bowel dysfunction in clinical and research settings.
Associations Of Apgar Score And Size At Birth With Lipoprotein Subclasses In Juvenile Obesity, Osama Bekhet, Jelena Vekic, Aleksandra Zeljkovic, Dusan Paripovic, Tamara Gojkovic, Jelena Janac, Vesna Spasojevic-Kalimanovska, Amira Peco-Antic, Gordana Milosevski-Lomic, Zorana Jelic-Ivanovic, Aleksandra Stefanovic
Associations Of Apgar Score And Size At Birth With Lipoprotein Subclasses In Juvenile Obesity, Osama Bekhet, Jelena Vekic, Aleksandra Zeljkovic, Dusan Paripovic, Tamara Gojkovic, Jelena Janac, Vesna Spasojevic-Kalimanovska, Amira Peco-Antic, Gordana Milosevski-Lomic, Zorana Jelic-Ivanovic, Aleksandra Stefanovic
Turkish Journal of Medical Sciences
Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions.Materials and methods: We included 42 obese children, aged 14.2 ± 2.1 years. LDL and HDL subfractions were separated by gradient …
Tnf-Α And Tgf-Ss Level After Intraoperative Allogeneic Red Blood Cell Transfusion In Orthopedic Operation Patients, Hamed Hassani, Alireza Khoshdel, Seyed Reza Sharifzadeh, Mohammad Foad Heydari, Shaban Alizadeh, Ali Noroozi Aghideh
Tnf-Α And Tgf-Ss Level After Intraoperative Allogeneic Red Blood Cell Transfusion In Orthopedic Operation Patients, Hamed Hassani, Alireza Khoshdel, Seyed Reza Sharifzadeh, Mohammad Foad Heydari, Shaban Alizadeh, Ali Noroozi Aghideh
Turkish Journal of Medical Sciences
Background/aim: Blood transfusion is associated with immunosuppression, referred to as transfusion-related immunomodulation (TRIM). In this study, for the first time, changes in the concentration of TGF-ß and TNF-α were measured postoperatively in orthopedic patients with intraoperational allogeneic red blood cell transfusion. Considering the use of packed cell units with different ages, it is possible to suggest the more appropriate product for clinical applications.Materials and methods: Two groups of 35 orthopedic surgery patients (with or without transfusion as case and control groups, respectively) were involved. Serum levels of TNF-α and TGF-ß were measured by ELISA.Results: The data suggested significant differences in …
Topographic Methods To Expose The Exiting Points Of Supratrochlear, Supraorbital, And Zygomaticotemporal Nerves, Mesut Sabri̇ Tezer, İsmai̇l Yağmurhan Gi̇lan, Özlem Elvan, Vedi̇a Bennu Özcömert, Mustafa Akteki̇n
Topographic Methods To Expose The Exiting Points Of Supratrochlear, Supraorbital, And Zygomaticotemporal Nerves, Mesut Sabri̇ Tezer, İsmai̇l Yağmurhan Gi̇lan, Özlem Elvan, Vedi̇a Bennu Özcömert, Mustafa Akteki̇n
Turkish Journal of Medical Sciences
Background/aim: We evaluated the relations of the exiting points of supratrochlear (STN), supraorbital (SON), and zygomaticotemporal (ZTN) nerves with certain landmarks to provide improved anatomic knowledge. Materials and methods: The twenty-eight hemifaces of 5 fresh frozen and 11 embalmed heads (5 female and 11 male cadavers) were dissected. Distance and angular measurements were made between the exiting points of the nerves to the midline, lateral, and medial canthi. Comparisons of side, sex, and cadaver groups were evaluated.Results: Mean values were determined for all parameters. There was no difference between side measurements. There were significant differences between sexes and cadaver groups …
Adaptation, Reliability, And Validity Study Of The Hwalek-Sengstockelder Abuse Screening Test (H-S/East): A Turkish Version, Ni̇lgün Özçakar, Akça Toprak Ergönen, Mehtap Kartal, Hakan Baydur
Adaptation, Reliability, And Validity Study Of The Hwalek-Sengstockelder Abuse Screening Test (H-S/East): A Turkish Version, Ni̇lgün Özçakar, Akça Toprak Ergönen, Mehtap Kartal, Hakan Baydur
Turkish Journal of Medical Sciences
Background/aim: The most important issues in elder abuse and neglect are lack of awareness and difficulties in determining the situation. Our aim is to determine the reliability and validity of the Turkish version of the Hwalek-Sengstock Elder Abuse Screening Test (H-S/EAST).Materials and methods: The H-S/EAST (15-itemed, three-dimensional: direct abuse, characteristics of vulnerability, and potentially abusive situation) was translated according to the guidelines and experts evaluated it for content validity and cultural adaptation. Participants' (n = 252) mean age was 73.4 ± 6.4 years and 58.3% were female. The World Health Organization Quality of Life Instrument-Older Adults Module (WHOQOL-OLD) and the …
Isolation And Culture Of Adult Mouse Vestibular Nucleus Neurons, Aydin Hi̇m, Serap Altuntaş, Gürkan Öztürk, Ender Erdoğan, Nureddi̇n Cengi̇z
Isolation And Culture Of Adult Mouse Vestibular Nucleus Neurons, Aydin Hi̇m, Serap Altuntaş, Gürkan Öztürk, Ender Erdoğan, Nureddi̇n Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: Isolated cell cultures are widely used to study neuronal properties due to their advantages. Although embryonic animals are preferred for culturing, their morphological or electrophysiological properties may not reflect adult neurons, which may be important in neurodegenerative diseases. This paper aims to develop a method for preparing isolated cell cultures of medial vestibular nucleus (MVN) from adult mice and describe its morphological and electrophysiological properties.Materials and methods: Vestibular nucleus neurons were mechanically and enzymatically isolated and cultured using a defined medium with known growth factors. Cell survival was measured with propidium iodide, and electrophysiological properties were investigated with current-clamp …
The Reno-Protective Effects Of Atorvastatin In Crush Syndrome And Rhabdomyolysis:Is There A Dilemma?, Demet Acar, Mustafa Gülpembe, Can Gökay Yildiz, Emi̇ne Nur Özdamar, Kerem Açikgöz, Ahmet Çağlar, Başar Cander
The Reno-Protective Effects Of Atorvastatin In Crush Syndrome And Rhabdomyolysis:Is There A Dilemma?, Demet Acar, Mustafa Gülpembe, Can Gökay Yildiz, Emi̇ne Nur Özdamar, Kerem Açikgöz, Ahmet Çağlar, Başar Cander
Turkish Journal of Medical Sciences
Background/aim: We aim to determine the effects of low-dose atorvastatin treatment together with crush fluid resuscitation on renal functions and muscle enzyme levels in a rat model of crush syndrome. Materials and methods: The study involved female Wistar Albino rats weighing 250-300 g that were housed with free access to food and water. The crush model was obtained by compression. Rats were randomly divided into four groups: control (C) group, atorvastatin + crush fluid (ACF) group, crush fluid (CF) group, and hypertonic saline (%3) + mannitol + sodium bicarbonate (SM) group. Blood was obtained at 24, 48, and 72 h, …
Islet Transplantation Promotes Podocyte Regeneration In A Model Of Diabetic Nephropathy, Ziqiang Xu, Jie Fan
Islet Transplantation Promotes Podocyte Regeneration In A Model Of Diabetic Nephropathy, Ziqiang Xu, Jie Fan
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to observe whether islet transplantation could induce glomerular parietal epithelial cells to express podocyte proteins in a rat model of streptozotocin-induced diabetic nephropathy (DN).Materials and methods: A total of 18 rats were given single injections of streptozotocin to induce a DN model. Eight weeks after the modeling, successfully established DN rats were divided into three groups: an untreated group (DN group), an islet-transplanted group (IT group), and an insulin group (IN group). The islets cells were isolated from donor rats and surgically transplanted from under the kidney capsule in the IT group. Four …
Chemokine Cxcr-4 And Cyclooxygenase-2 In The Pathogenesis Of Pterygium, Gönen Başer, Oya Nermi̇n Si̇vri̇koz, Eyyüp Karahan, Emi̇ne Şeker Ün, Hakan Yildirim, Sülen Sarioğlu
Chemokine Cxcr-4 And Cyclooxygenase-2 In The Pathogenesis Of Pterygium, Gönen Başer, Oya Nermi̇n Si̇vri̇koz, Eyyüp Karahan, Emi̇ne Şeker Ün, Hakan Yildirim, Sülen Sarioğlu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the expression of chemokine receptor 4 (CXCR-4) and cyclooxygenase-2 (COX-2) in the epithelium and stroma of pterygium tissue in comparison with healthy conjunctiva. Materials and methods: The expression of CXCR4 and COX-2 was investigated by immunohistochemistry in the epithelium and stroma of the pterygium tissue of 29 eyes and compared with healthy conjunctival tissues. The correlation between CXCR4 and COX-2 expression as well as the correlation of these markers with the area of pterygium were evaluated statistically. Results: COX-2 staining scores were 1.75 ± 0.63 in the epithelium and 1.20 ± 0.62 in the …
Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay
Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay
Turkish Journal of Medical Sciences
Background/aim: Intracranial stenosis (ICS) is identified in 2.2%?70.4% of patients with ischemic stroke and transient ischemic attack. This study aimed to determine the prevalence of ICS in a single center registry from Turkey. Materials and methods: We reviewed the charts of 619 patients with acute ischemic stroke. ICS was defined as any ICS > 50% on cerebrovascular imaging. The demographic data, risk factors, NIHSS scores and C reactive protein level at admission, mortality in hospital, recurrent stroke, and mRS in the follow-up period were recorded. Results: A total of 72 (11.6%) patients with ICS (45 males (62.5%); mean age 68.3 ± …
The Effectiveness And Clinical Outcomes Of The Minerva Cervical Thoracicjacket In Patients With Type Ii Odontoid Fractures, Sai̇t Öztürk, Fati̇h Serhat Erol, Beki̇r Akgün, Meti̇n Kaplan
The Effectiveness And Clinical Outcomes Of The Minerva Cervical Thoracicjacket In Patients With Type Ii Odontoid Fractures, Sai̇t Öztürk, Fati̇h Serhat Erol, Beki̇r Akgün, Meti̇n Kaplan
Turkish Journal of Medical Sciences
Background/aim: The objective of this study was to carry out a detailed analysis and assess the outcomes for the Minerva cervical thoracic jacket (CTJ) in patients with type II odontoid fractures who could not be surgically treated. Materials and methods: Twenty-six patients for whom the Minerva CTJ was used rather than surgery for different reasons were included in the study. All patients were fitted with the Minerva CTJ within the first 24 h following diagnosis. The patients were followed 4 weeks after hospital discharge and then at 2-week intervals. Results were considered significant at P < 0.05 and a 95% confidence interval was calculated. Results: Of the 26 patients, 17 were male and 9 were female. The mean age was 49.03 years old (range: 16?86 years old). Fusion occurred in 25 of the 26 patients (P = 0.004), and the mean time to fusion was 6.8 weeks (P = 0.002). The mean length of hospital stay was 4 days and the mean follow-up period was 7.3 weeks. None of the patients had any complications due to the Minerva CTJ and the mortality rate was 0%. Conclusions: The Minerva CTJ application was a safe and cheap technique in the management of type II odontoid fractures. It had a high fusion rate and no complications.
The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan
The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to emphasize the importance of routine bedside biliary ultrasonography (USG) for the differential diagnosis of biliary tract disorders in patients admitted with acute isolated epigastric pain. Materials and methods: Adult patients who were admitted to the emergency department with acute isolated epigastric pain were included in the study. Emergency residents (ERs) were asked whether they planned to perform biliary USG during the initial evaluation and following diagnosis/treatment (secondary evaluation) of these patients. Bedside biliary USG examinations were performed by a sonologist and a radiologist evaluated the video recordings. Results: A total of 103 …
Differences In Leptin, Ghrelin, And Glucagon-Like Peptide-1 Levelsbetween Religious Fasting And Normal Fasting, Özge Telci̇ Çaklili, Banu Başok, Gülcan Yavuz, Selcan Tülü, Banu Mesçi̇, Ayteki̇n Oğuz
Differences In Leptin, Ghrelin, And Glucagon-Like Peptide-1 Levelsbetween Religious Fasting And Normal Fasting, Özge Telci̇ Çaklili, Banu Başok, Gülcan Yavuz, Selcan Tülü, Banu Mesçi̇, Ayteki̇n Oğuz
Turkish Journal of Medical Sciences
Background/aim: Leptin, ghrelin, and glucagon-like peptide-1 (GLP-1) affect hunger, satiety feelings, and food intake. We hypothesized that during Ramadan, if the brain knows that the body will be hungry until sunset, there may be differences between leptin, ghrelin, and GLP-1 levels in Ramadan and non-Ramadan fasting. Materials and methods: This study had two phases. In the first phase, the participants were asked to skip the dawn meal of Ramadan (suhur), so that 12 h of fasting could be achieved. Participants ceased food intake at midnight, and at noon blood was drawn. Eight participants were selected as a subgroup. These participants …
Relationship Of Paratracheal Lymph Nodes With The Progression Of Chronic Autoimmune Thyroiditis: 5-Year Follow-Up Results, Gülhan Akbaba, Di̇lek Berker, Serhat Işik, Nari̇n Nasiroğlu İmga, Feri̇t Keri̇m Küçükler, Yasemi̇n Tütüncü, Serdar Güler
Relationship Of Paratracheal Lymph Nodes With The Progression Of Chronic Autoimmune Thyroiditis: 5-Year Follow-Up Results, Gülhan Akbaba, Di̇lek Berker, Serhat Işik, Nari̇n Nasiroğlu İmga, Feri̇t Keri̇m Küçükler, Yasemi̇n Tütüncü, Serdar Güler
Turkish Journal of Medical Sciences
Background/aim: To examine changes in paratracheal lymph nodes (PLNs) and the relationship with the course of the disease in patients with chronic autoimmune thyroiditis (CAT) 5 years after diagnosis. Materials and methods: A total of 169 patients with newly diagnosed CAT and 53 healthy subjects were included in the study. All patients underwent ultrasonographic (US) examinations of the thyroid, paratracheal regions, and examined thyroid function tests. Eighty-four patients who were euthyroid at baseline and who were contacted 5 years after the diagnosis were reevaluated by US and thyroid function tests. Results: The PLNs frequency was significantly higher in the CAT …