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Articles 1981 - 2010 of 4871
Full-Text Articles in Medicine and Health Sciences
Mediterranean Fever (Mefv) Gene Mutations In Glomerulonephritides: A Clinicopathological Study, Ufuk İlgen, Gökhan Nergi̇zoğlu
Mediterranean Fever (Mefv) Gene Mutations In Glomerulonephritides: A Clinicopathological Study, Ufuk İlgen, Gökhan Nergi̇zoğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to determine the ME diterranean F e V er ( MEFV ) gene mutation carrier rate in patients with glomerulonephritis and to investigate the association between disease features and MEFV variants. Materials and methods: Medical records regarding clinical, laboratory, histopathological, and prognostic features of 200 adult patients with biopsy-proven glomerulonephritis were evaluated retrospectively. Exons 2 and 10 of the MEFV gene of each patient were sequenced by next-generation sequencing. Variants were detected and compared with disease features. Results: MEFV mutation carrier rate was 25%, similar among disease subgroups, and higher than the previously …
Hemostatic Effects Of Adrenaline And Ankaferd (Blood Stopper) During Orthodontic Attachment Bonding, Selen Adi̇loğlu, Alper Aktaş, Aslihan Zeynep Öz, Hakan El
Hemostatic Effects Of Adrenaline And Ankaferd (Blood Stopper) During Orthodontic Attachment Bonding, Selen Adi̇loğlu, Alper Aktaş, Aslihan Zeynep Öz, Hakan El
Turkish Journal of Medical Sciences
Background/aim: Moisture prevention during the bonding of orthodontic attachments on impacted teeth is crucial for accomplishment. It was aimed to compare the hemostatic effects of adrenaline and Ankaferd Blood Stopper (ABS) during the surgical exposure of the impacted maxillary canine. Materials and methods: The study consists of 20 patients, whose orthodontic treatments were outlined with the surgical exposure of maxillary impacted canine. Patients were divided into groups of 10; where each group was treated with one of the two medicines to control bleeding. Group A was treated with adrenaline, and group B was treated with Ankaferd Blood Stopper (ABS). The …
Submucous Cleft Palate: From Diagnosis To Management, Mavi̇ş Emel Kulak Kayikci, Şadi̇ye Bacik Tirank, Mert Çaliş, F. Fi̇gen Özgür, Riza Önder Günaydin
Submucous Cleft Palate: From Diagnosis To Management, Mavi̇ş Emel Kulak Kayikci, Şadi̇ye Bacik Tirank, Mert Çaliş, F. Fi̇gen Özgür, Riza Önder Günaydin
Turkish Journal of Medical Sciences
Background/aim : The aim of this study was to investigate submucous cleft palate (SMCP) patients in order to document the age of diagnosis, cause of referral, symptoms and palate findings, objective evaluation of nasalance and velopharyngeal dysfunction (VPD), and intervention type. Material and methods : The archive of Hacettepe University Cleft Lip and Palate, Craniomaxillofacial Anomalies Research, Treatment, and Application Center was reviewed retrospectively, and 166 patients diagnosed with SMCP were documented. Results : The mean age of the patients at the time of initial referral was 10 years and 3 months ± 8 years and 5 months with the …
Losartan Inhibits Egfr Transactivation In Vascular Smooth Muscle Cells, Mustafa Kirça, Akin Yeşi̇lkaya
Losartan Inhibits Egfr Transactivation In Vascular Smooth Muscle Cells, Mustafa Kirça, Akin Yeşi̇lkaya
Turkish Journal of Medical Sciences
Background/aim: Angiotensin II (Ang II)-induced molecular signaling pathways play a significant role in the progression of cardiovascular diseases, including hypertension and atherosclerosis. In addition to the well-known effects of Ang II, it may activate epidermal growth factor receptor (EGFR) in a process known as transactivation, which contributes to vascular pathologies. The aim of this study was to determine whether losartan could reduce EGFR transactivation induced by Ang II. Additionally, we evaluated the roles of heparin-binding epidermal-like growth factor (HB-EGF) and matrix metalloproteinases (MMPs) in Ang II-induced EGFR transactivation. Materials and methods: Vascular smooth muscle cells were isolated from a rat …
Demonstration Of The Effect Of Brivaracetam On An Experimental Epilepsy Model, Mustafa Çeti̇ner, Hasan Emre Aydin
Demonstration Of The Effect Of Brivaracetam On An Experimental Epilepsy Model, Mustafa Çeti̇ner, Hasan Emre Aydin
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of valproic acid (VPA) and a new-generation antiepileptic drug called brivaracetam (BRV) on the brain damage occurring after status epilepticus (SE) in rats. Materials and methods: In our study, an experimental animal model of SE, generated by stereotaxically injecting 0.4-2 μg of kainic acid into the rat hippocampus, was used. The laboratory animals were divided into 4 groups: the first group was a sham group that was subjected to anesthesia and SE was not induced; the second group was a SE group, in which SE was induced using kainic …
Investigation Of The Effect Of Combined Use Of Alloplastic-Based Tricalcium Phosphate Bone Graft And Antihemorrhagic Plant Extract (Abs) On Bone Regeneration In Surgically Induced Bone Defects In Nondiabetic Rats: An Experimental Animal Study, Abdulsamet Tani̇k, Arzum Güler Doğru, Veysi̇ Akpolat, Fi̇li̇z Acun Kaya, Ebru Saribaş, Mehmet Gül, Sevgi̇ İrtegün, Engi̇n Deveci̇
Investigation Of The Effect Of Combined Use Of Alloplastic-Based Tricalcium Phosphate Bone Graft And Antihemorrhagic Plant Extract (Abs) On Bone Regeneration In Surgically Induced Bone Defects In Nondiabetic Rats: An Experimental Animal Study, Abdulsamet Tani̇k, Arzum Güler Doğru, Veysi̇ Akpolat, Fi̇li̇z Acun Kaya, Ebru Saribaş, Mehmet Gül, Sevgi̇ İrtegün, Engi̇n Deveci̇
Turkish Journal of Medical Sciences
Background/aim: In this experimental study, we aimed to evaluate the late period effects of the combination of Ankaferd Blood Stopper (ABS), which has bone wound healing effects, and ß-tricalcium phosphate (TCP) on the regeneration of bone tissue through histopathological, immunohistochemical, and radiological (dual energy X-ray absorptiometry - DEXA) methods in nondiabetic rats. Materials and methods: Sixty-four Wistar albino male rats were used. In the calvaria of the rats, a bone defect 7.0 mm in diameter was created. These rats were divided into 4 different groups. Group 1 was the control group without any treatment, a 0.125 mL B-TCP graft was …
Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan
Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan
Turkish Journal of Medical Sciences
Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries. Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Blood pressures of rats were observed daily. On the day 20, rats were executed. Protein levels in urine were measured and fetuses, placentas, and kidneys were weighted and evaluated. Thoracic aorta, renal, and uterine arteries were removed for …
Is The Extent Of Surgical Resection Important In Patient Outcome In Benign And Borderline Phyllodes Tumors Of The Breast?, Ali̇ İbrahi̇m Sevi̇nç, Süleyman Özkan Aksoy, Meri̇h Güray Durak, Pinar Balci
Is The Extent Of Surgical Resection Important In Patient Outcome In Benign And Borderline Phyllodes Tumors Of The Breast?, Ali̇ İbrahi̇m Sevi̇nç, Süleyman Özkan Aksoy, Meri̇h Güray Durak, Pinar Balci
Turkish Journal of Medical Sciences
Background/aim: Phyllodes tumors (PTs) of the breast are rare, and their diagnosis and treatment remain controversial. This retrospective study aims to examine the clinical outcome of benign and borderline PTs, according to the surgical margins. Materials and methods: We examined the medical records of 122 patients in our clinic, who had histologically confirmed benign and borderline PTs between 1994 and 2017. Results: The mean age of the patients was 40.6 years (range 18.0-81.0, ±12.1 standard deviation [SD]) and the mean tumor size was 25.8 mm (range 9-65, ±10.3 SD). All patients underwent a breast-conserving procedure and the median follow-up was …
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Relationship Between Pk2 And Number Of Kupffer Cells Duringthe Progression Of Liver Fibrosis In Patients With Hbv, Xiao-Qin Liu, Rong-Rong Wei, Cheng-Cheng Wang, Li-Yu Chen, Cong Liu, Kai Liu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the potential regulatory role of prokineticin 2 (PK2) in modulation of the number and function of Kupffer cells (KCs) during the progression of liver fibrosis in patients with hepatitis B virus (HBV). Materials and methods: We obtained liver tissue sections from 200 patients with HBV undergoing surgical resection in our hospital between January 2013 and July 2016. Of these 200 tissue sections, 150 were fibrosis tissues and 50 were hepatocellular carcinoma tissues. Immunohistochemical evaluations were performed to assess the expression levels of CD68 and PK2 in the sections. The clinical parameters of these 200 …
Carfilzomib Experience In Relapsed/Refractory Multiplemyeloma: A Single-Center Experience, Ayşe Uysal, Nur Akad Soyer, Melda Özkan, Fahri̇ Şahi̇n, Fi̇li̇z Vural, Mahmut Töbü, Murat Tombuloğlu, Güray Saydam
Carfilzomib Experience In Relapsed/Refractory Multiplemyeloma: A Single-Center Experience, Ayşe Uysal, Nur Akad Soyer, Melda Özkan, Fahri̇ Şahi̇n, Fi̇li̇z Vural, Mahmut Töbü, Murat Tombuloğlu, Güray Saydam
Turkish Journal of Medical Sciences
Background/aim: Carfilzomib (CFZ) is a new-generation proteasome inhibitor with significant activity in relapsed or refractory multiple myeloma (R/R-MM). We have retrospectively evaluated R/R-MM patients who were treated with CFZ plus dexamethasone. Materials and methods: Twenty-one R/R-MM patients who were treated with CFZ plus dexamethasone between October 2013 and January 2016 were screened. The patients were followed until March 2016 after CFZ treatment. Results: Ten (47.6%) of the patients were female and 11 (52.4%) of them were male. The median age was 62 (47-76) years. The median number of prior treatment lines was 3 (2-7). The median number of administered cycles …
Translocation Breakpoints Of Chromosome 3 In Male Carriers: A Report Oftwelve Cases And A Review Of The Literature, Hongguo Zhang, Ruixue Wang, Linlin Li, Haibo Zhu, Hao Zhang, Ruizhi Liu
Translocation Breakpoints Of Chromosome 3 In Male Carriers: A Report Oftwelve Cases And A Review Of The Literature, Hongguo Zhang, Ruixue Wang, Linlin Li, Haibo Zhu, Hao Zhang, Ruizhi Liu
Turkish Journal of Medical Sciences
Background/aim: This study aimed to explore the breakpoints in chromosome 3 translocation and the clinical features present in male carriers to enable informed genetic counseling of these patients. Materials and methods: A total of 5235 men who were infertile or receiving counseling for infertility were recruited. Cytogenetic analyses were performed using G-banding. A search for translocations on chromosome 3 involved in male infertility was performed using PubMed, Google Scholar, and CNKI. The relationships of translocation breakpoints with male infertility and recurrent pregnancy loss were also analyzed. Results: Among the 82 patients with balanced reciprocal translocations among 5235 male patients, 12 …
Neutrophil-To-Lymphocyte Ratio And Microvascular Complications In Subjects With Type 2 Diabetes: Pakistan′S Perspective, Asher Fawwad, Anum Mehmood Butt, Iftikhar Ahmed Siddiqui, Maria Khalid, Rubina Sabir, Abdul Basit
Neutrophil-To-Lymphocyte Ratio And Microvascular Complications In Subjects With Type 2 Diabetes: Pakistan′S Perspective, Asher Fawwad, Anum Mehmood Butt, Iftikhar Ahmed Siddiqui, Maria Khalid, Rubina Sabir, Abdul Basit
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to find the association between diabetic microvascular complications and the neutrophil-to-lymphocyte ratio (NLR) in subjects with type 2 diabetes. Materials and methods: This was a retrospective study based on hospital data records from January 2005 to May 2016 at the Baqai Institute of Diabetology and Endocrinology. The eligibility criteria included subjects with type 2 diabetes with their latest complete blood count while subjects with conditions such as chronic inflammation, cancer, heart failure, and end-stage renal disease were not eligible for inclusion. Subjects were divided into two groups: one with any microvascular complications and …
Protective Effect Of Erdosteine On Erythrocyte Deformabilityin A Rat Model Of Lower Limb Ischemia/Reperfusion Injury, Abdullah Özer, Hüseyi̇n Demi̇rtaş, Faruk Meti̇n Çomu, Di̇lek Erer, Yi̇ği̇t Kiliç, Bariş Mardi̇n, Mustafa Arslan, Ayşegül Küçük, Gürsel Levent Oktar
Protective Effect Of Erdosteine On Erythrocyte Deformabilityin A Rat Model Of Lower Limb Ischemia/Reperfusion Injury, Abdullah Özer, Hüseyi̇n Demi̇rtaş, Faruk Meti̇n Çomu, Di̇lek Erer, Yi̇ği̇t Kiliç, Bariş Mardi̇n, Mustafa Arslan, Ayşegül Küçük, Gürsel Levent Oktar
Turkish Journal of Medical Sciences
Background/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control', n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion', n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg$^{-1}$, intraperitoneally (group 'ischemia/reperfusion - erdosteine', …
Emotion Regulation And Premedication Success Relationship In Children Who Underwent General Anesthesia, Aslihan Aykut, Berri̇n Işik
Emotion Regulation And Premedication Success Relationship In Children Who Underwent General Anesthesia, Aslihan Aykut, Berri̇n Işik
Turkish Journal of Medical Sciences
Background/aim: is study aims to investigate the relationship between emotion regulation characteristics and the e cacy of midazolam premedication. Materials and methods: Sixty-three children, aged 3 to 8 years old, with tonsillectomy and/or adenoidectomy and taking premedication with midazolam (Group 2) or without premedication (Group 1), were included in this study. e behavioral and emotional status of the children was evaluated with the Conners Parent Rating Scale-48 (CPRS-48) and Emotion Regulation Checklist (ERC). Age, sex, body weight, response to intravenous (IV) cannulation and mask, hemodynamic data, preoperative sedation scores [Wilton Sedation Scale (WSS)], postoperative pain intensity [Objective Pain Scale (OPS)], …
Extracorporeal Membrane Oxygenation Support In Neonates: A Single Center Experience In Turkey, Emel Okulu, Fatma Begüm Atasay, Gaffari̇ Tunç, Hasan Akduman, Ömer Erdeve, Saadet Arsan, Zeynep Eyi̇leten, Tayfun Uçar, Hasan Ercan Tutar
Extracorporeal Membrane Oxygenation Support In Neonates: A Single Center Experience In Turkey, Emel Okulu, Fatma Begüm Atasay, Gaffari̇ Tunç, Hasan Akduman, Ömer Erdeve, Saadet Arsan, Zeynep Eyi̇leten, Tayfun Uçar, Hasan Ercan Tutar
Turkish Journal of Medical Sciences
Background/aim: Extracorporeal membrane oxygenation (ECMO) is a form of life support for patients with respiratory failure, cardiac failure, or both. e aim of this study was to evaluate neonates supported with ECMO and report our experience as a Turkish neonatal intensive care unit. Materials and methods: We retrospectively reviewed 11 newborn infants treated with ECMO at Ankara University for respiratory and cardiac failure. We reported the demographic, diagnostic, laboratory, and clinical data of the patients. Results: Eleven patients (9 male, 2 female) received ECMO support with a mean gestational age of 39.1 ± 1.6 weeks and mean birth weight of …
Factors Associated With Social Anxiety Disorder In A Group Of Obese Turkish Female Patients, Akatli Kürşad Özşahi̇n, Ebru Altintaş
Factors Associated With Social Anxiety Disorder In A Group Of Obese Turkish Female Patients, Akatli Kürşad Özşahi̇n, Ebru Altintaş
Turkish Journal of Medical Sciences
Background/aim: Mental disorders may accompany obesity. is study aims to evaluate the association between social anxiety disorder (SAD) and obesity and the risk factors for SAD in obese female patients. Materials and methods: A total of 114 obese patients and 110 healthy controls were included. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), State and Trait Anxiety Inventory (STAI I-II), and Liebowitz Social Anxiety Scale (LSAS) were administered to assess anxiety, depression, and social anxiety levels. Scale scores were analyzed statistically. Results: The rate of SAD in obese female patients was found to be 8.8%. Anxiety, depression, and social …
Fat Grafting To The Face With Adjunctive Microneedling: A Simpletechnique With High Patient Satisfaction, Bi̇llur Sezgi̇n, Selahatti̇n Özmen
Fat Grafting To The Face With Adjunctive Microneedling: A Simpletechnique With High Patient Satisfaction, Bi̇llur Sezgi̇n, Selahatti̇n Özmen
Turkish Journal of Medical Sciences
Background/aim: Even though new techniques are emerging to overcome the inconsistent long-term viability of fat grafts, current methods for increasing fat graft survival are not routinely adaptable to all clinical environments. The purpose of this study was to determine the efficacy of microneedling as an adjunct to fat grafting to the face. Materials and methods: Twenty-two patients that underwent fat grafting to the face with adjunctive microneedling were evaluated in terms of improvement in facial skin quality and facial volume and their results were compared to those in 18 patients that underwent fat grafting without microneedling. The evaluation was conducted …
Efficacy And Safety Of Lenalidomide And Dexamethasone In Patients With Relapsed/Refractory Multiple Myeloma: A Real-Life Experience, Nur Soyer, Püsem Patir, Ayşe Uysal, Mustafa Duran, Hati̇ce Demet Ki̇per Ünal, İsabel Rai̇ka Durusoy Onmuş, Murat Tombuloğlu, Fahri̇ Şahi̇n, Mahmut Töbü, Fi̇li̇z Vural, Güray Saydam
Efficacy And Safety Of Lenalidomide And Dexamethasone In Patients With Relapsed/Refractory Multiple Myeloma: A Real-Life Experience, Nur Soyer, Püsem Patir, Ayşe Uysal, Mustafa Duran, Hati̇ce Demet Ki̇per Ünal, İsabel Rai̇ka Durusoy Onmuş, Murat Tombuloğlu, Fahri̇ Şahi̇n, Mahmut Töbü, Fi̇li̇z Vural, Güray Saydam
Turkish Journal of Medical Sciences
Background/aim: In Turkey, lenalidomide plus dexamethasone (RD) has been used to treat relapsed/refractory multiple myeloma (RRMM) since 2010. This retrospective, single-center study evaluated the efficacy and tolerability of RD in patients with RRMM between October 2010 and June 2016. Materials and methods: Patients' records were reviewed, and overall (OS) and progression-free survival (PFS) were assessed. Results: One hundred and twenty patients (71 males; 59.2%) were included in the study. The median number of prior lines of treatment was one (1-4); 72 patients (60.0%) received RD as second-line therapy and 51 patients (42.5%) had previously undergone autologous stem cell transplantation (ASCT). …
The Validity And Reliability Of The Turkish Version Of The Leicester Cough Questionnairein Copd Patients, Fi̇kret Kurhan, Tuğba Göktalay, Yavuz Havlucu, Seçi̇l Sari, Ayşe Arzu Yorgancioğlu, Pinar Çeli̇k, Ayşin Şakar Coşkun
The Validity And Reliability Of The Turkish Version Of The Leicester Cough Questionnairein Copd Patients, Fi̇kret Kurhan, Tuğba Göktalay, Yavuz Havlucu, Seçi̇l Sari, Ayşe Arzu Yorgancioğlu, Pinar Çeli̇k, Ayşin Şakar Coşkun
Turkish Journal of Medical Sciences
Background/aim: The reliability and validity of the Turkish version of the Leicester Cough Questionnaire (LCQ) have been evaluated before. This study aimed to validate the Turkish version of the LCQ in chronic obstructive pulmonary disease (COPD) patients with cough. Materials and methods: COPD (GOLD B, C, D) patients over age 40 (n = 75) and healthy volunteers as a control group (n = 75) were included. A sociodemographic data form, the LCQ, the Short Form-36 (SF-36) quality of life questionnaire, and the World Health Organization Quality of Life Brief Form for Turkish people were completed. The internal reliability of the …
Peripheral Arterial Disease Increases The Risk Of Multidrug-Resistant Bacteria Andamputation In Diabetic Foot Infections, Pinar Aysert Yildiz, Tuğba Özdi̇l, Murat Di̇zbay, Özlem Güzel Tunçcan, Kenan Hizel
Peripheral Arterial Disease Increases The Risk Of Multidrug-Resistant Bacteria Andamputation In Diabetic Foot Infections, Pinar Aysert Yildiz, Tuğba Özdi̇l, Murat Di̇zbay, Özlem Güzel Tunçcan, Kenan Hizel
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the microbiological profile and resistance rates of diabetic foot infections (DFIs) and to determine the effect of peripheral arterial disease (PAD) on the microbiology, clinical condition, and treatment outcomes. Materials and methods: Characteristics, laboratory and imaging data, and the treatment modalities of patients admitted to our hospital with a diagnosis of DFI (PEDIS classification 3-4) during 2005-2016 were analyzed according to the presence of PAD. Results: Of 112 patients who were included in this study, 86 (76.8%) had PAD. Patients with PAD were older and had higher amputation rates (P < 0.05). A microbiological profile of patients revealed a predominance of gram-positive bacteria (57.1%). Staphylococcus aureus and Streptococcus spp. were the most frequently encountered bacteria. Incidence of Pseudomonas spp. infection was higher in the PAD group (P < 0.05). Of all patients, 24.1% had multidrug-resistant (MDR) microorganisms in their wound cultures. Presence of MDR bacteria in patients with PAD was 4.9-fold higher than that in patients without PAD (P < 0.05). Conclusion: This retrospective study indicates that PAD has a significant role, especially in elderly patients with DFIs. Patients should be promptly evaluated and treated for PAD to prevent infections with resistant microorganisms and limb loss.
Ketamine Dosing For Sedation During Repeated Radiotherapy Sessions In Children, Oya Yalçin Çok, Hati̇ce Evren Eker, Ani̇ş Ariboğan
Ketamine Dosing For Sedation During Repeated Radiotherapy Sessions In Children, Oya Yalçin Çok, Hati̇ce Evren Eker, Ani̇ş Ariboğan
Turkish Journal of Medical Sciences
Background/aim: We report the analysis of ketamine doses needed and the recovery times in pediatric oncology patients undergoing repeated radiotherapy sessions. Materials and methods: In a single-blind prospective study design, thirty-three pediatric patients undergoing radiotherapy due to oncologic disorders received 2 mg/kg ketamine and 10 μg/kg atropine intravenously and the rescue drug to be administered was ketamine at 0.5 mg/kg when the sedation level was inadequate. Total ketamine consumption, additional doses, and recovery time were recorded. Results: Data of 635 consecutive radiotherapy sessions were evaluated. There was no significant alteration in total ketamine consumption required to complete the radiotherapy periods …
Clinical, Neuroradiological, And Electroencephalographic Findings Of Reflex Epilepsies, Gi̇zem Gürsoy, Kemal Tutkavul, Yilmaz Çeti̇nkaya, Hülya Ti̇reli̇
Clinical, Neuroradiological, And Electroencephalographic Findings Of Reflex Epilepsies, Gi̇zem Gürsoy, Kemal Tutkavul, Yilmaz Çeti̇nkaya, Hülya Ti̇reli̇
Turkish Journal of Medical Sciences
Background/aim: Reflex seizures are defined as epilepsies with seizures induced by a specific afferent stimulus or patient activity alone or in combination with spontaneous seizures, and/or accompanied by photoparoxysmal response on electroencephalogram (EEG). The aim of this study is to review and analyze clinical, neuroradiological, and EEG findings in reflex epilepsies. Materials and methods: The records of 1598 follow-up patients out of 2237 patients who had been examined between July 1995 and August 2017 were analyzed retrospectively. Results: Eighty of 1598 patients had reflex epilepsy and 72 of those patients had seizures induced by visual stimuli. Considering the somatosensory stimuli, …
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Factors Influencing The Success Of Cord Blood Collection: A Tertiary Perinatal Medicinecenter's Experience, Atakan Tanaçan, Pinar Yurdakul Mesutoğlu, Fati̇h Aktoz, Gökçen Örgül, Meral Beksaç, Mehmet Si̇nan Beksaç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord …
Patient Symptoms And Magnetic Resonance Imaging Correlationin Temporomandibular Joint Internal Derangement, Osman Akdağ, Gökçe Yildiran, Mehtap Karameşe
Patient Symptoms And Magnetic Resonance Imaging Correlationin Temporomandibular Joint Internal Derangement, Osman Akdağ, Gökçe Yildiran, Mehtap Karameşe
Turkish Journal of Medical Sciences
Background/aim: Temporomandibular joint (TMJ) internal derangements consist of reduced and nonreduced disc dislocations and are often diagnosed by magnetic resonance imaging (MRI). The main symptom of these derangements is TMJ pain. This study aimed to evaluate whether there is a correlation between TMJ pain and disc dislocation. Materials and methods: One hundred and four patients experiencing pain were evaluated retrospectively with the examination charts that we use routinely in our clinics and MRI. Patients were separated into two main groups as MRI(+) and MRI(-) groups according to their internal derangement findings in MRI. Mean VAS levels were compared between these …
Sexual Dysfunction In Patients With Systemic Sclerosis, İsmai̇l Uçar, Batuhan Turgay, Orhan Küçükşahi̇n, Esma Özkan Uçar, Tahsi̇n Murat Turgay
Sexual Dysfunction In Patients With Systemic Sclerosis, İsmai̇l Uçar, Batuhan Turgay, Orhan Küçükşahi̇n, Esma Özkan Uçar, Tahsi̇n Murat Turgay
Turkish Journal of Medical Sciences
Background/aim: The aim of the study was to investigate the effect of systemic sclerosis (SSc) on quality of life and sexual function in female patients. Materials and methods: The study included 30 sexually active female patients with SSc and 30 healthy control subjects. For all participants in both the patient and control groups, the female sexual index and SF-36 forms were completed and a detailed medical and sexual history was taken. Results: The mean age was 45.03 ± 9.22 years in the SSc group and 44.6 ± 11.52 years in the control group (P = 0.87). The SF-36 scores in …
Interleukin 12b Mrna Level And Rs3212227 Genotyping In Peripheral Blood Mononuclear Cells Of Inflammatory Bowel Disease Patients, Hamid Asadzadeh Aghdaie, Elnaz Emami, Mahyar Nourian, Vahid Chaleshi, Peyman Tarban, Hedieh Balaii, Pedram Azimzadeh, Shiva Irani, Shabnam Shahrokh, Mohammad Rostami-Nejad, Mohamad Reza Zali
Interleukin 12b Mrna Level And Rs3212227 Genotyping In Peripheral Blood Mononuclear Cells Of Inflammatory Bowel Disease Patients, Hamid Asadzadeh Aghdaie, Elnaz Emami, Mahyar Nourian, Vahid Chaleshi, Peyman Tarban, Hedieh Balaii, Pedram Azimzadeh, Shiva Irani, Shabnam Shahrokh, Mohammad Rostami-Nejad, Mohamad Reza Zali
Turkish Journal of Medical Sciences
Background/aim: Inflammatory bowel disease (IBD) is a multifactorial disorder. Single nucleotide polymorphisms (SNPs) in the IL-12 gene, which are the main factors to regulate the immune reaction, play an important role in the production of IL-12 molecules. The aim of this study was to evaluate the correlation between the SNP on position +1188 of the 3 ' UTR region of the IL-12 p40 subunit gene and expression of the IL-12 p40 gene. Materials and methods: This case-control study was performed with 102 patients with IBD and 107 healthy people. PCR-RFLP and comparative real-time PCR were performed to assess the association …
Is Vaginally Assisted Laparoscopic Sacrohystero/Colpopexy A Feasible Technique?, Ömer Lütfi̇ Tapisiz, Ali̇ Riza Doğan, Şadiman Kiykaç Altinbaş
Is Vaginally Assisted Laparoscopic Sacrohystero/Colpopexy A Feasible Technique?, Ömer Lütfi̇ Tapisiz, Ali̇ Riza Doğan, Şadiman Kiykaç Altinbaş
Turkish Journal of Medical Sciences
No abstract provided.
Effectiveness Of New Parameters In The Evaluation Of Pneumoperitoneum-Related Acute Kidney Injury In Rats, Ramazan Kozan, Mustafa Şare, Tonguç Utku Yilmaz, Seher Yüksel, Mehmet Şeneş, Ayşe Banu Çayci, Şükrü Bozkurt
Effectiveness Of New Parameters In The Evaluation Of Pneumoperitoneum-Related Acute Kidney Injury In Rats, Ramazan Kozan, Mustafa Şare, Tonguç Utku Yilmaz, Seher Yüksel, Mehmet Şeneş, Ayşe Banu Çayci, Şükrü Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Pneumoperitoneum with high pressure results in decreased glomerular filtration rates (GFRs). Cystatin-C (Cys-C), neutrophil gelatinase-associated lipocalin (NGAL), and interleukin 18 (IL-18) are new parameters in the evaluation of GFR instead of creatinine. The aim of this study is to show the effects of pneumoperitoneum on renal function with the help of these new acute kidney injury markers. Materials and methods: Sixty rats were divided into 10 groups according to the length of time and degree of pneumoperitoneum pressure achieved during CO2 insufflation: 0 mmHg (control) for 1 h; 4 mmHg for 1, 2, and 4 h; 8 mmHg for …
Common Spink-1 Genetic Mutations Do Not Predispose To Crohn`S Disease, Nevi̇n Oruç, Necla Osmanoğlu, Çağdaş Aktan, Afi̇g Berdeli̇, Ahmet Ömer Özütemi̇z
Common Spink-1 Genetic Mutations Do Not Predispose To Crohn`S Disease, Nevi̇n Oruç, Necla Osmanoğlu, Çağdaş Aktan, Afi̇g Berdeli̇, Ahmet Ömer Özütemi̇z
Turkish Journal of Medical Sciences
No abstract provided.
A Prospective Follow-Up Of Quality Of Life, Depression, Andanxiety In Children With Lymphoma And Solid Tumors, Ni̇hal Sargin Yildirim, Meti̇n Demi̇rkaya, Betül Berri̇n Sevi̇ni̇r, Sali̇h Güler, Ayşe Pinar Vural, Candan Demi̇röz, Arzu Çirpan Kantarcioğlu
A Prospective Follow-Up Of Quality Of Life, Depression, Andanxiety In Children With Lymphoma And Solid Tumors, Ni̇hal Sargin Yildirim, Meti̇n Demi̇rkaya, Betül Berri̇n Sevi̇ni̇r, Sali̇h Güler, Ayşe Pinar Vural, Candan Demi̇röz, Arzu Çirpan Kantarcioğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was the determination and prospective follow-up of quality of life, depression, and anxiety in pediatric patients with cancer under chemotherapy, as well as the evaluation of related factors. Materials and methods: Fifty newly diagnosed pediatric cancer patients and their parents were prospectively monitored before, during, and after therapy, and tests were used. Results: Significantly lower quality of life scores were recorded during treatment, in the group with CNS tumors, in the group receiving chemotherapy plus radiotherapy plus surgery, in the inpatient-only treatment group, in the group receiving treatment for longer than 6 months, and …