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Articles 1291 - 1320 of 4871
Full-Text Articles in Medicine and Health Sciences
Maintenance Of Pulmonary Rehabilitation Benefits In Patients With Copd: Is A Structured5-Year Follow-Up Program Helpful?, İpek Candemi̇r, Pinar Ergün, Mustafa Engi̇n Şahi̇n
Maintenance Of Pulmonary Rehabilitation Benefits In Patients With Copd: Is A Structured5-Year Follow-Up Program Helpful?, İpek Candemi̇r, Pinar Ergün, Mustafa Engi̇n Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Pulmonary rehabilitation (PR) has proven useful in patients with chronic obstructive pulmonary disease (COPD), but the benefits decrease over time. We evaluated the effects of a structured follow-up program after PR on patient pulmonary function, dyspnea, body composition, exercise capacity, quality of life, psychological status, i-BODE index, hospitalization status, 5-year survival rate. We explored whether this follow-up program could serve as a maintenance program. Materials and methods: COPD patients who completed PR attended follow-up visits over 5 years. We administered incremental (ISWT), endurance shuttle walk tests (ESWT), measured body (BMI), fat-free mass indices (FFMI), recorded modified Medical Research Council …
Clinicopathological Features Of Mammary Paget's Disease: A Single-Center Experience Inturkey, Haldun Kar, Sultan Deni̇z Altindağ, Demet Eti̇t, Seyran Yi̇ği̇t, Ni̇han Acar, Mustafa Agah Teki̇ndal, Emi̇ne Özlem Gür, Betül Bolat Küçükzeybek, Özgün Akgül, Murat Kemal Atahan
Clinicopathological Features Of Mammary Paget's Disease: A Single-Center Experience Inturkey, Haldun Kar, Sultan Deni̇z Altindağ, Demet Eti̇t, Seyran Yi̇ği̇t, Ni̇han Acar, Mustafa Agah Teki̇ndal, Emi̇ne Özlem Gür, Betül Bolat Küçükzeybek, Özgün Akgül, Murat Kemal Atahan
Turkish Journal of Medical Sciences
Background/aim: Paget's disease (PD) of the breast is a very rare presentation of breast malignancy, accounting for 1%-3% of all primary breast tumors. We aimed to evaluate and compare the clinicopathological features and clinical outcome of PD accompanied by in situ carcinoma and invasive cancer. Materials and methods: We used the archive of our pathology laboratory retrospectively for age, sex, history of surgery, histopathological findings, treatment modalities, and follow-up information. We used the Kaplan-Meier method for survival analysis. Results: There were 46 female patients diagnosed with PD. In 39 (84.7%) patients, invasive carcinoma accompanied PD, while 7 (15.3%) patients had …
Lobectomy May Not Be Suitable For Patients With Follicular Neoplasm Cytology, Beki̇r Uçan, Mustafa Şahi̇n, Mustafa Özbek, Muhammed Kizilgül, Müyesser Sayki Arslan, Mustafa Çalişkan, Güleser Saylam, Erman Çakal
Lobectomy May Not Be Suitable For Patients With Follicular Neoplasm Cytology, Beki̇r Uçan, Mustafa Şahi̇n, Mustafa Özbek, Muhammed Kizilgül, Müyesser Sayki Arslan, Mustafa Çalişkan, Güleser Saylam, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: The most appropriate surgical management of follicular neoplasm/suspicious for follicular neoplasm (FN) lesions is still contradictory. We aimed to evaluate the data of our patients with follicular neoplasm treated with thyroidectomy. Materials and methods: We retrospectively analyzed the data of 74 patients who were diagnosed with follicular neoplasm cytology (FN cytology) by fine needle aspiration biopsy (FNAB) and had undergone total thyroidectomy or lobectomy with isthmectomy (LwI). Results: We examineda total of 74 patients, of which 64 (83.7%) were female and 10 (16.3%) were male. The malignancy rate in the pathological examinations of these patients was 31/74 (41.9%). The …
Continuous Venovenous Hemodiafiltration In The Treatment Of Newborns With An Inborn Metabolic Disease: A Single Center Experience, Hasan Akduman, Emel Okulu, Fatma Tuba Emi̇noğlu, Tanil Kendi̇rli̇, Gaffari̇ Tunç, Ebru Azapağasi, Oktay Perk, Ömer Erdeve, Begum Atasay, Saadet Arsan
Continuous Venovenous Hemodiafiltration In The Treatment Of Newborns With An Inborn Metabolic Disease: A Single Center Experience, Hasan Akduman, Emel Okulu, Fatma Tuba Emi̇noğlu, Tanil Kendi̇rli̇, Gaffari̇ Tunç, Ebru Azapağasi, Oktay Perk, Ömer Erdeve, Begum Atasay, Saadet Arsan
Turkish Journal of Medical Sciences
Background/aim: Most inborn metabolic diseases are diagnosed during the neonatal period. The accumulation of toxic metabolites may cause acute metabolic crisis with long-term neurological dysfunction and death. Renal replacement therapy (RRT) modalities allow the efficient removal of toxic metabolites. In this study, we reviewed our experience with continuous venovenous hemodiafiltration (CVVHDF) as RRT for newborns with an inborn metabolic disease.Materials and methods: Patients diagnosed with an inborn metabolic disease and who received CVVHDF treatment at our neonatal intensive care unit between January 2014 and December 2017 were included in this study. Their demographic and clinical data were collected, and the …
The Surgical Outcomes Of Trans-Scaphoid Perilunate Fracture-Dislocations, Cemal Kural, Bülent Tanriverdi̇, Ersi̇n Erçi̇n, Emre Baca, Murat Yilmaz
The Surgical Outcomes Of Trans-Scaphoid Perilunate Fracture-Dislocations, Cemal Kural, Bülent Tanriverdi̇, Ersi̇n Erçi̇n, Emre Baca, Murat Yilmaz
Turkish Journal of Medical Sciences
Background/aim: Trans-scaphoid perilunate fracture-dislocation (TSPFD) is a rare injury. TSPFD is a fracture-dislocation that severely disrupts the anatomical structure of the carpal bones and may occur as a result of a high energy trauma of the wrist or a fall on an open hand. In this study, the aim is to provide midterm clinical and radiological evaluations of cases diagnosed and treated as TSPFD.Materials and methods: Eleven patients diagnosed with TSPFD as a result of wrist trauma were treated surgically and were analysed retrospectively. Clinical and radiological follow-up of the cases was evaluated. The mean age of the patients was …
Multicenter Study Of Levodopa Carbidopa Intestinal Gel In Parkinson's Disease: The Turkish Experience, Murat Gülteki̇n, Çağri Ulukan, Sabi̇ha Tezcan Aydemi̇r, Okan Doğu, Haşmet Ayhan Hanağasi, Başar Bi̇lgi̇ç, Ayşe Bora Tokçaer, Rai̇f Çakmur, Bülent Eli̇bol, Meral Mi̇rza, Di̇lek Günal, Çi̇ğdem Sevda Erer Özbek, Gülay Kenangi̇l, Özge Yilmaz Küsbeci̇, Muhi̇tti̇n Cenk Akbostanci
Multicenter Study Of Levodopa Carbidopa Intestinal Gel In Parkinson's Disease: The Turkish Experience, Murat Gülteki̇n, Çağri Ulukan, Sabi̇ha Tezcan Aydemi̇r, Okan Doğu, Haşmet Ayhan Hanağasi, Başar Bi̇lgi̇ç, Ayşe Bora Tokçaer, Rai̇f Çakmur, Bülent Eli̇bol, Meral Mi̇rza, Di̇lek Günal, Çi̇ğdem Sevda Erer Özbek, Gülay Kenangi̇l, Özge Yilmaz Küsbeci̇, Muhi̇tti̇n Cenk Akbostanci
Turkish Journal of Medical Sciences
Background/aim: Our purpose was to determine the efficacy of levodopa carbidopa intestinal gel (LCIG) in a series of Turkish patients with Parkinson's disease (PD). Materials and methods: We had telephone calls with 54 patients from 11 neurology centers who were on LCIG treatment, and 44 patients or their caregivers were included in an eight-item survey between September 2015 and June 2016. The reliability and validity of the survey were evaluated with intraclass correlation coefficients for every question separately.Results: Average age of the patients were 63.48 and the duration of PD was 12.79 years. Average LCIG treatment period was 15.63 months. …
Can The Efficacy Of Subacromial Corticosteroid Injection Be Improved Using A Single-Session Mobilization Treatment In Subacromial Impingement Syndrome? A Randomized Single-Blind Controlled Trial, Fazil Kulakli, İlker İlhanli, İlker Fati̇h Sari, Adem Türköz, Canan Çeli̇k
Can The Efficacy Of Subacromial Corticosteroid Injection Be Improved Using A Single-Session Mobilization Treatment In Subacromial Impingement Syndrome? A Randomized Single-Blind Controlled Trial, Fazil Kulakli, İlker İlhanli, İlker Fati̇h Sari, Adem Türköz, Canan Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: The objective in this study is to assess the short-term effects of a single-session mobilization in addition to subacromial corticosteroid (SACS) injection in impingement syndrome.Materials and methods: The study was designed as a prospective randomized controlled single-blind, parallel group clinical trial. Patients (totally 84) were divided randomly into two groups equally. Forty-two patients in Group 1 received mobilization and SACS injection, whereas 42 patients in Group 2 only received SACS injections. A single SACS injection was applied in all patients. Mobilization was administered as a single session right after SACS injection. Patient' evaluations were performed measuring active range of …
Smokeless Tobacco Use And Risk Of Oral Cavity Cancer, Shah Zeb Khan, Ahmed Farooq, Misbah Masood, Abubaker Shahid, Irfan Ullah Khan, Hasan Nisar, Ismat Fatima
Smokeless Tobacco Use And Risk Of Oral Cavity Cancer, Shah Zeb Khan, Ahmed Farooq, Misbah Masood, Abubaker Shahid, Irfan Ullah Khan, Hasan Nisar, Ismat Fatima
Turkish Journal of Medical Sciences
Background/aim: Smokeless tobacco has been associated with oral cavity cancer for several decades. The incidence of oral cavity cancer is higher in some parts of the world especially South and South-East Asia including Pakistan. The aim of current study was to evaluate the risk of oral cavity cancer among smokeless tobacco users in our country. Materials and methods: A case-control study was conducted between November 2016 and September 2017. Patients diagnosed with oral cavity cancer receiving treatment were included as cases and the attendants of various cancer patients visiting the hospital during the study period were included in the study …
Midkine Level May Be Used As A Noninvasive Biomarker In Crohn's Disease, Murat Keki̇lli̇, Alpaslan Tanoğlu, Fati̇h Karaahmet, Zeynal Doğan, Murat Can, Abdurrahi̇m Sayilir, Başak Çakal, Tolga Düzenli̇, Yavuz Beyazi̇t
Midkine Level May Be Used As A Noninvasive Biomarker In Crohn's Disease, Murat Keki̇lli̇, Alpaslan Tanoğlu, Fati̇h Karaahmet, Zeynal Doğan, Murat Can, Abdurrahi̇m Sayilir, Başak Çakal, Tolga Düzenli̇, Yavuz Beyazi̇t
Turkish Journal of Medical Sciences
Background/aim: Crohn's disease (CD) is a kind of inflammatory bowel disease. Midkine (MDK) is an endogenous inflammatory marker. We aimed to investigate the relationship between MDK levels and inflammation and hence determine whether MDK can be used as a noninvasive biomarker in active CD. Materials and methods: Sixty-five consecutive patients over the age of 18 with CD and 36 healthy controls were included in this study. CD patients' venous blood samples were taken before treatment. Serum MDK levels were determined in human plasma samples by enzyme-linked immunosorbent assay (ELISA) method. Results: The mean age of the study patients was 44.8 …
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Turkish Journal of Medical Sciences
Background/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, …
The Use Of Prealbumin As A Predictor Of Malnutrition In Cirrhotic Patients And The Effectof Nutritional Support In Patients With Low Prealbumin Levels, Zuhal Dağ, Hüseyi̇n Köseoğlu, Murat Keki̇lli̇
The Use Of Prealbumin As A Predictor Of Malnutrition In Cirrhotic Patients And The Effectof Nutritional Support In Patients With Low Prealbumin Levels, Zuhal Dağ, Hüseyi̇n Köseoğlu, Murat Keki̇lli̇
Turkish Journal of Medical Sciences
Background/aim: Malnutrition is an important and commonly seen prognostic factor in patients with cirrhosis. The diagnosis of malnutrition in cirrhosis patients may be challenging, and an easily measured and widely usable marker is lacking. Prealbumin, however, is an easily measured marker. In the current study we measured prealbumin levels in cirrhotic patients with no clinically apparent malnutrition and used it as a malnutrition marker. Another aim of this study was to evaluate the effect of nutritional support on patient with low prealbumin levels. Materials and methods: Fifty-two patients with Child A and Child B cirrhosis were selected for the study. …
Somatic Regional Oxygen Saturation As An Early Marker Of Intra-Abdominal Hypertensionin Critically Ill Children: A Pilot Study, Özden Özgür Horoz, Vahi̇de Nagehan Aslan, Riza Di̇nçer Yildizdaş, Yasemi̇n Çoban, Yaşar Sertdemi̇r, Awni Al-Subu
Somatic Regional Oxygen Saturation As An Early Marker Of Intra-Abdominal Hypertensionin Critically Ill Children: A Pilot Study, Özden Özgür Horoz, Vahi̇de Nagehan Aslan, Riza Di̇nçer Yildizdaş, Yasemi̇n Çoban, Yaşar Sertdemi̇r, Awni Al-Subu
Turkish Journal of Medical Sciences
Background/aim: Intraabdominal hypertension is a common clinical condition with high mortality and morbidity in pediatric intensive care units. The aim of this study was to test the feasibility of regional tissue oxygenation (rSO2 ) measurement using nearinfrared spectroscopy and to assess the correlation between rSO2 and perfusion markers of intraabdominal hypertension in high-risk pediatric patients. Materials and methods: In this prospective observational cohort study in a tertiary pediatric intensive care unit in Çukurova University Faculty of Medicine, a total of 31 patients who were admitted between May 2017 and May 2018 with a risk of intraabdominal hypertension were included. Mesenteric …
Shearwave Elastographic Evaluation Of Uterine Leiomyomas After Uterine Arteryembolization: Preliminary Results, Cesur Samanci, Yilmaz Önal
Shearwave Elastographic Evaluation Of Uterine Leiomyomas After Uterine Arteryembolization: Preliminary Results, Cesur Samanci, Yilmaz Önal
Turkish Journal of Medical Sciences
Background/aim: We aimed to investigate the role of Shearwave Elastography (SWE) in the evaluation of response to uterine artery embolization (UAE) in patients with uterine leiomyomas. Materials and methods: SWE images of the dominant uterin leiomyomas were obtained before and 1.5 months after performing UAE in 33 women suffering from symptoms due to leiomyomas (menometrorrhagia, bulk related symptoms, pelvic pain). Leiomyomas were also evaluated by 2 observers for location and longest diameter in axial plane. Interobserver agreement in the quantitative SWE analysis was calculated using intraclass correlation coefficients. Results: Thirty-three women (mean age, 39.7 years; range, 31-48 years) were examined …
Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar
Effect Of Metformin And Detorsion Treatment On Serum Anti-Müllerian Hormonelevels And Ovarian Histopathology In A Rat Ovarian Torsion Model, Sema Karakaş, Ci̇han Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyi̇n Cengi̇z, Murat Eki̇n, Levent Yaşar
Turkish Journal of Medical Sciences
Background/aim: Adnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluate the effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model. Materials and methods: Twenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The …
Reliability And Validity Of The Turkish Version Of The Diabetes Distress Scale For Type 2diabetes And Distress Levels Of The Participants, Özge Telci̇ Çaklili, Güneş Feyi̇zoğlu, Selcan Tülü Çolak, Nazli Di̇zman, Sidika İrem Bozkurt Çakir, Ayteki̇n Oğuz
Reliability And Validity Of The Turkish Version Of The Diabetes Distress Scale For Type 2diabetes And Distress Levels Of The Participants, Özge Telci̇ Çaklili, Güneş Feyi̇zoğlu, Selcan Tülü Çolak, Nazli Di̇zman, Sidika İrem Bozkurt Çakir, Ayteki̇n Oğuz
Turkish Journal of Medical Sciences
Background/aim: Studies have shown an increased depression rate in patients with type 2 diabetes mellitus (T2DM) compared to the normal population. It is now acknowledged that patients suffer from distress rather than depression. Our aim was to validate the Turkish version of the Diabetes Distress Scale (DDS) and to show distress levels of the participants. Materials and methods: The scale was translated from English to Turkish by the authors and translated back to English. Between August 2015 and January 2016 all the patients who were referred to the T2DM Clinic of İstanbul Medeniyet University were screened, and eligible patients were …
The Validity And Reliability Of The Turkish Version Of The Body Esteem Scale Foradolescents And Adults (Besaa) For Children, Umut Ece Arslan, Lütfi̇ye Hi̇lal Özcebe, Hande Konşuk Ünlü, Sarp Üner, Mahmut Saadi̇ Yardim, Ozgur Araz, Terry T-K Huang
The Validity And Reliability Of The Turkish Version Of The Body Esteem Scale Foradolescents And Adults (Besaa) For Children, Umut Ece Arslan, Lütfi̇ye Hi̇lal Özcebe, Hande Konşuk Ünlü, Sarp Üner, Mahmut Saadi̇ Yardim, Ozgur Araz, Terry T-K Huang
Turkish Journal of Medical Sciences
Background/aim: Body esteem (BE) is defined as the self-evaluation of one's own body or appearance. The Body Esteem Scale for Adolescents and Adults (BESAA) consists of three subscales: BE-appearance, BE-weight, and BE-attribution. Though initially developed for adolescents and adults, the use of the scale has recently increased in health-related research on children. This study aimed to assess the validity and reliability of the Turkish version of the BESAA for children. Materials and methods: The participants in the study were 4th grade children (aged 9-10 years) in Ankara, Turkey. The validity of the scale was evaluated through exploratory and confirmatory factor …
Is There Relationship Between Sars-Cov-2 And The Complement C3 And C4?, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay
Is There Relationship Between Sars-Cov-2 And The Complement C3 And C4?, Hamad Dhei̇r, Savaş Si̇pahi̇, Selçuk Yaylaci, Mehmet Köroğlu, Ali̇ Fuat Erdem, Oğuz Karabay
Turkish Journal of Medical Sciences
No abstract provided.
The Antibiotic Prescribing Behaviors Of Physicians Are Changed Via Rapid Antigen Testpractice In The Context Of Rational Drug Use, Deni̇z Uzun, Hali̇l Kara, Muhammed Fati̇h Doğan, Seyfullah Oktay Arslan
The Antibiotic Prescribing Behaviors Of Physicians Are Changed Via Rapid Antigen Testpractice In The Context Of Rational Drug Use, Deni̇z Uzun, Hali̇l Kara, Muhammed Fati̇h Doğan, Seyfullah Oktay Arslan
Turkish Journal of Medical Sciences
Background/aim: Rapid antigen test (RAT) is a practical test to detect the presence of Group A beta hemolytic streptococcus antigens in throat swab samples. The aim of this study is to investigate the changes in the empiric antibiotic prescribing behavior of 10 family physicians in Kırıkkale Province after using RAT in 2017. Materials and methods: RAT test practice started in Family Medicine in February 2017. Family Medicine Information System (FMIS) includes clinical and prescription records of 10 family physicians, providing health service to approximately 35,000 residents in Kırıkkale. The numbers of antibiotics prescribed by the physicians according to the ICD-10 …
Evaluation Of Brain Fdg Pet Images In Temporal Lobe Epilepsy For Lateralization Ofepileptogenic Focus Using Data Mining Methods, Ümi̇t Özgür Akdemi̇r, İrem Çapraz, Seda Gülbahar Ateş, Keri̇m Şeker, Uğuray Aydos, Gökhan Kurt, Neşe Karabacak, Lütfi̇ye Özlem Atay, Erhan Bi̇li̇r
Evaluation Of Brain Fdg Pet Images In Temporal Lobe Epilepsy For Lateralization Ofepileptogenic Focus Using Data Mining Methods, Ümi̇t Özgür Akdemi̇r, İrem Çapraz, Seda Gülbahar Ateş, Keri̇m Şeker, Uğuray Aydos, Gökhan Kurt, Neşe Karabacak, Lütfi̇ye Özlem Atay, Erhan Bi̇li̇r
Turkish Journal of Medical Sciences
Background/aim: In temporal lobe epilepsy (TLE), brain positron emission tomography (PET) performed with F-18 fluorodeoxyglucose (FDG) is commonly used for lateralization of the epileptogenic temporal lobe. In this study, we aimed to evaluate the success of quantitative analysis of brain FDG PET images using data mining methods in the lateralization of the epileptogenic temporal lobe. Materials and methods: Presurgical interictal brain FDG PET images of 49 adult mesial TLE patients with a minimum of 2 years of postsurgical follow-up and Engel I outcomes were retrospectively analyzed. Asymmetry indices were calculated from PET images from the mesial temporal lobe and its …
The Effect Of Vitamin D Status On Different Neuromuscular Blocker Agents Reverse Time, İlknur Sui̇di̇ye Yorulmaz, Yavuz Demi̇raran, Onur Özlü, Burhan Dost
The Effect Of Vitamin D Status On Different Neuromuscular Blocker Agents Reverse Time, İlknur Sui̇di̇ye Yorulmaz, Yavuz Demi̇raran, Onur Özlü, Burhan Dost
Turkish Journal of Medical Sciences
Background/aim: This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times. Material and methods: Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery under general anesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. At the end of the operation, sugammadex 2 mg/kg was administered to one group (Group sugammadex) and atropine and neostigmine was administered to the other group (Group neostigmine) intravenously. In the data analysis stage, the group was …
Mean Platelet Volume And Response To The First Line Therapy In Newly Diagnosed Adultimmune Thrombocytopenia Patients: A Retrospective Study, Erman Akkuş, Çi̇ğdem Fi̇dan, Gülşah Demi̇rci̇, Ali̇ Aytuğ Kuştaş, Meltem Yüksel
Mean Platelet Volume And Response To The First Line Therapy In Newly Diagnosed Adultimmune Thrombocytopenia Patients: A Retrospective Study, Erman Akkuş, Çi̇ğdem Fi̇dan, Gülşah Demi̇rci̇, Ali̇ Aytuğ Kuştaş, Meltem Yüksel
Turkish Journal of Medical Sciences
Background/aim: Immune thrombocytopenia (ITP) is treated by corticosteroids and/or intravenous immune globulin as the first line treatment when necessary. Mean platelet volume (MPV) is a marker of platelet production and function. In this study, we aimed to search the relationship between the MPV and the treatment response in ITP patients and it was hypothesized that MPV can be used as a predictor of the response. Materials and methods: The 70 newly diagnosed adult primary ITP patients and 70 of healthy people were included. MPV between ITP and healthy population, MPV in the diagnosis and after the treatment between the responders …
Cross-Cultural Adaptation, Reliability And Validity Of The Turkish Version Of Patient-Specific Functional Scale In Patients With Chronic Neck Pain, Gamze Yalçinkaya, Bi̇lge Kara, Mehmet Nuri̇ Arda
Cross-Cultural Adaptation, Reliability And Validity Of The Turkish Version Of Patient-Specific Functional Scale In Patients With Chronic Neck Pain, Gamze Yalçinkaya, Bi̇lge Kara, Mehmet Nuri̇ Arda
Turkish Journal of Medical Sciences
Background/aim: Current clinical guidelines recommend to use both clinical and self-reported measurements for evaluation of chronic neck pain. Among the self-reported outcomes, Neck disability index and patient-specific functional scale are the most widely used and recommended instruments. The purpose of our study was to determine the test-retest reliability and validity of patient-specific functional scale which was not validated in Turkish language previously. Materials and methods: Translation and adaptation process had conducted according to the Beaton et al. Sociodemographic data, Turkish version of patient-specific functional scale and neck disability index were recorded at the initial assessment. Retest assessment was produced for …
Clinical Evaluation Of Pituitary Insufficiency In Adult Population, Selvi̇han Beysel, Mustafa Çalişkan, Muhammed Kizilgül, Seyfullah Kan, Mustafa Özbek, Erman Çakal
Clinical Evaluation Of Pituitary Insufficiency In Adult Population, Selvi̇han Beysel, Mustafa Çalişkan, Muhammed Kizilgül, Seyfullah Kan, Mustafa Özbek, Erman Çakal
Turkish Journal of Medical Sciences
Background/aim: This retrospective study aimed to investigate the clinical profile of pituitary insufficiency (PI) in adult population. Materials and methods: One hundred and fifty patients who were diagnosed as having PI between 2012 and 2018 (53.3% female, mean age 48.13 ± 15.83 years) were retrospectively analyzed. Results: Age at diagnosis was higher in females as compared with males (51.13 ± 15.95 vs. 44.70 ± 15.08 years, P = 0.012). The most frequent presenting signs were headache (29.4%) and visual disturbance (19.6%) in general. Females frequently presented with headache (33.3%), whereas males presented with sexual dysfunction (34.4%). The most frequent cause …
Horse Allergen Sensitivity And Respiratory Symptoms Among Horse Farm Workers, Burcu Baran Ketenci̇oğlu, İnsu Yilmaz, Nuri̇ Tutar, İnci̇ Gülmez, Fatma Sema Oymak
Horse Allergen Sensitivity And Respiratory Symptoms Among Horse Farm Workers, Burcu Baran Ketenci̇oğlu, İnsu Yilmaz, Nuri̇ Tutar, İnci̇ Gülmez, Fatma Sema Oymak
Turkish Journal of Medical Sciences
Background/aim: Sensitivity and symptoms related to animal proteins have been investigated in various occupational groups. However, data from horse farm workers are limited. We aimed to determine horse allergen sensitivity in the horse farm workers, and to evaluate its relationship with respiratory symptoms and functional parameters. Materials and methods: A total of 110 subjects were enrolled in the study. The study group consisted of 80 horse farm workers. Face-to-face surveys, skin prick tests (SPT), and pulmonary function tests (PFT) were performed in the study group. Control group consisted of 30 healthy subjects. SPT and PFTs were also performed for control …
Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu
Neurotrophic Factors In Bipolar Disorders Patients With Manic Episode, Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çeti̇n, Ebru Kaynar Tunçel, Bi̇rşen Bi̇lgi̇ci̇, Arzu Karaustaoğlu
Turkish Journal of Medical Sciences
Background/aim: Neurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity. The amount of evidence about the role of changes in neuroplasticity in the pathophysiology of bipolar disease is growing. Materials and methods: We measured serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), glial cell-line derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), fibroblast growth factor (FGF)-2, neuritin 1 (Nrn 1) in bipolar 1 manic episode patients (n = 45) and healthy control group. Results: When controlled for age, BMI and cortisol, it was found that the serum …
Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu
Prospective Evaluation Of Vascular Changes In Acute Respiratory Infections In Children With Cystic Fibrosis, Gökçen Kartal Öztürk, Aykut Eşki̇, Fi̇gen Çelebi̇ Çeli̇k, Seçi̇l Conkar, Fi̇gen Gülen, Esen Demi̇r, Ahmet Keski̇noğlu
Turkish Journal of Medical Sciences
Background/aim: Acute exacerbations and chronic inflammation are risk factors for cardiovascular disease (CVD) in cystic fibrosis (CF) patients. The aim of this study was to investigate the effects of acute exacerbation therapy on arterial stiffness in children with CF. Materials and methods: Augmentation index (Aix) and pulse wave velocity (PWV) were measured before and after treatment and 1 month after the end of treatment in patients with acute exacerbation. The relationship between hemodynamic measurements and c-reactive protein (CRP) and pulmonary function tests (PFTs) was investigated. Results: Measurements before and after treatment were evaluated in 27 patients and were repeated in …
Dti-Mri Findings In Synthetic Cannabinoid Users, Fatma Di̇lek Gökharman, Sonay Aydin, Sali̇h Ci̇hat Paltun, Erdem Fati̇hoğlu, Şafak Yalçin Şahi̇ner, Pinar Nerci̇s Koşar
Dti-Mri Findings In Synthetic Cannabinoid Users, Fatma Di̇lek Gökharman, Sonay Aydin, Sali̇h Ci̇hat Paltun, Erdem Fati̇hoğlu, Şafak Yalçin Şahi̇ner, Pinar Nerci̇s Koşar
Turkish Journal of Medical Sciences
Background/aim: Synthetic cannabinoids (SCs) are full agonists of both cannabinoid receptors. Conventional magnetic resonance imaging (MRI) findings of SC users are mainly defined as diffusion restriction and T2/FLAIR hyperintensity. Diffusion tensor imaging (DTI) studies examining SC users have shown contradictory results. The aim of this study was to define white matter (WM) changes of SC users using DTI. Materials and methods: The study included 22 patients with a history of using SC for 5-37 months, and 22 healthy, age and sex- matched control subjects. A total of 41 diffusion gradient directions were used in the acquisition of diffusion imaging data. …
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Turkish Journal of Medical Sciences
Background/aim: We aimed to explore the roles of glycoprotein glycosylation in the pathogenesis of Kashin-Beck disease (KBD), and evaluated the effectiveness of sodium hyaluronate treatment. Materials and methods: Blood and saliva were collected from KBD patients before and after the injection of sodium hyaluronate. Normal healthy subjects were included as controls. Saliva and serum lectin microarrays and saliva and serum microarray verifications were used to screen and confirm the differences in lectin levels among the three groups. Results: In saliva lectin microarray, bindings to Sophora japonica agglutinin (SJA), Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I), Euonymus europaeus lectin (EEL), Maackia amurensis …
Changes In P1 Latencies Of Children With Normal Hearing And Those With Cochlear Implants, Emre Eski̇ci̇oğlu, Günay Kirkim, Selhan Gürkan, Serpi̇l Mungan Durankaya, Tahsi̇n Oğuz Başokçu, Eni̇s Alpi̇n Güneri̇
Changes In P1 Latencies Of Children With Normal Hearing And Those With Cochlear Implants, Emre Eski̇ci̇oğlu, Günay Kirkim, Selhan Gürkan, Serpi̇l Mungan Durankaya, Tahsi̇n Oğuz Başokçu, Eni̇s Alpi̇n Güneri̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the age-related latency interval of P1 latencies of children with normal hearing, and to evaluate the P1 latency changes after surgery in children who underwent cochlear implantation. Materials and methods: We evaluated 60 children with normal hearing and 16 children with cochlear implants aged 0-6 years using cortical auditory evoked potentials. P1 latencies were measured only once in the children with normal hearing, and on the postoperative first day, and the first, third, and sixth postoperative months in the children with cochlear implants. Results: There was a statistically significant decrease in …
Investigation The Potential Use Of Silver Nanoparticles Synthesized By Propolis Extract As N-Acyl-Homoserine Lactone-Mediated Quorum Sensing Systems Inhibitor, Sedef İlk, Gamze Tan, Ezgi̇ Emül, Necdet Sağlam
Investigation The Potential Use Of Silver Nanoparticles Synthesized By Propolis Extract As N-Acyl-Homoserine Lactone-Mediated Quorum Sensing Systems Inhibitor, Sedef İlk, Gamze Tan, Ezgi̇ Emül, Necdet Sağlam
Turkish Journal of Medical Sciences
Background/aim: Quorum sensing (QS) is a chemical communication process that bacteria use to regulate virulence. Inhibition of QS (antiQS) overcomes the pathogenicity of bacteria. Silver nanoparticles (AgNPs) have been used as antimicrobials against pathogens, but have not been used against QS-mediated bacterial infection. Also, studies have been carried out on the inhibitory effects of propolis based structures on pathogen growth, but no studies have been found on their potential use as QS inhibitor. The present study aims to investigate the synthesis and characterization of silver nanoparticles (AgNPs) reduced with propolis extract (P-AgNPs) and evaluation of their antimicrobial and, for the …