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Metastatic Biomarkers In Synovial Sarcoma, Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi 2017 Loma Linda University

Metastatic Biomarkers In Synovial Sarcoma, Rosalia De Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi

Library Articles and Research

Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of ...


Jpcrr Reviewers — 2016, 2017 Aurora Health Care

Jpcrr Reviewers — 2016

Journal of Patient-Centered Research and Reviews

N/A


Education Of Nurse Practitioners And Physician Assistants; What Role, If Any, For Physicians In Determining Their Scope Of Practice?, Joseph I. Shapiro 2017 Marshall University

Education Of Nurse Practitioners And Physician Assistants; What Role, If Any, For Physicians In Determining Their Scope Of Practice?, Joseph I. Shapiro

Marshall Journal of Medicine

Recent changes in legislation allow for non-physicians to independently perform many of the duties previously restricted to physicians. There are potentially benefits to these changes, but the author is concerned that some of the attributes of physicians induced by the long and rigorous training embedded in the profession may be absent in this new, independent health-care work force.


Forward By Editor, Benjamin J. Damazo 2017 Loma Linda University, School of Medicine

Forward By Editor, Benjamin J. Damazo

Loma Linda University Student Journal

No abstract provided.


Surveillance To Reduce Urinary Tract Infections: The Struti Project, Oyebola Fasugba, Anne Gardner, Brett G. Mitchell, Wendy Beckingham, Noleen Bennett 2017 Australian Catholic University

Surveillance To Reduce Urinary Tract Infections: The Struti Project, Oyebola Fasugba, Anne Gardner, Brett G. Mitchell, Wendy Beckingham, Noleen Bennett

Oyebola Fasugba

Researchers and infection control experts at Australian Catholic University’s School of Nursing, Midwifery and Paramedicine; Avondale College for Higher Education; Canberra Hospital; and Victorian Healthcare Associated Infection Surveillance Coordinating Centre are working in partnership to develop a national surveillance system for HAUTIs using point prevalence survey.


The Effectiveness Of A Volunteer-Delivered, Community-Based Lifestyle Modification Program (Chip) For Reducing The Risk Factors Associated With Metabolic Syndrome, Paul Rankin 2017 Avondale College of Higher Education

The Effectiveness Of A Volunteer-Delivered, Community-Based Lifestyle Modification Program (Chip) For Reducing The Risk Factors Associated With Metabolic Syndrome, Paul Rankin

Paul Rankin

In the latter half of the 20th Century increases in the availability of inexpensive, energy-dense foods combined with an estimated 60-70% reduction in daily energy expenditure, created an “obesogenic” environment. The epidemic of obesity that has emerged has been associated with the Metabolic Syndrome (MetS) which is a cluster of risk factors that are precursors to chronic diseases including cardiovascular disease (CVD), type II diabetes (T2D), stroke, and dementia. These chronic diseases are having a significant social and economic impact worldwide with their related morbidity and mortality.Epidemiological and interventional studies have shown that lifestyle interventions based on a low-fat ...


Gender Differences In Effectiveness Of The Complete Health Improvement Program, Lillian Kent, Darren Morton, Paul Rankin, John Gobble, Hans A. Diehl 2017 Avondale College of Higher Education

Gender Differences In Effectiveness Of The Complete Health Improvement Program, Lillian Kent, Darren Morton, Paul Rankin, John Gobble, Hans A. Diehl

Paul Rankin

Objective: To determine the differential effect of gender on outcomes of the Complete Health Improvement Program, a chronic disease lifestyle intervention program. Design: Thirty-day cohort study. Setting: One hundred thirty-six venues around North America, 2006 to 2009. Participants: A total of 5,046 participants (33.5% men, aged 57.9 ± 13.0 years; 66.5% women, aged 57.0 ± 12.9 years). Intervention: Diet, exercise, and stress management. Main Outcome Measures: Body mass index, diastolic blood pressure, systolic blood pressure, lipids, and fasting plasma glucose (FPG). Analysis: The researchers used t test and McNemar chi-square test of proportions, at P ...


Mapping Nad+ Metabolism In The Brain Of Ageing Wistar Rats: Potential Targets For Influencing Brain Senescence, Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, Gilles J. Guillemin, George Smythe, Perminder Sachdev 2017 University ofNew South Wales

Mapping Nad+ Metabolism In The Brain Of Ageing Wistar Rats: Potential Targets For Influencing Brain Senescence, Nady Braidy, Anne Poljak, Ross Grant, Tharusha Jayasena, Hussein Mansour, Tailoi Chan-Ling, Gilles J. Guillemin, George Smythe, Perminder Sachdev

Ross Grant

Over the last decade, the importance of NAD+ has expanded beyond its role as an essential cofactor for energy metabolism. NAD+ has emerged as a major signalling molecule that serves as the sole substrate for several enzymatic reactions including the DNA repair enzyme, poly(ADP-ribose) polymerase (PARP), NAD-dependent protein deacetylases or CD38, and transcriptional factors by a new class of histone deacetylases known as sirtuins. NAD+ Levels are regulated by the metabolic status and cellular stress caused by oxidative stress and DNA damage. Since a detailed study of NAD+ metabolism in the healthy ageing mammalian brain is nascent, we examined ...


Changes In Oxidative Damage, Inflammation And [Nad(H)] With Age In Cerebrospinal Fluid, Jade Guest, Ross Grant, Trevor A. Mori, Kevin D. Croft 2017 Australasian Research Institute

Changes In Oxidative Damage, Inflammation And [Nad(H)] With Age In Cerebrospinal Fluid, Jade Guest, Ross Grant, Trevor A. Mori, Kevin D. Croft

Ross Grant

An extensive body of evidence indicates that oxidative stress and inflammation play a central role in the degenerative changes of systemic tissues in aging. However a comparatively limited amount of data is available to verify whether these processes also contribute to normal aging within the brain. High levels of oxidative damage results in key cellular changes including a reduction in available nicotinamide adenine dinucleotide (NAD+), an essential molecule required for a number of vital cellular processes including DNA repair, immune signaling and epigenetic processing.

In this study we quantified changes in [NAD(H)] and markers of inflammation and oxidative damage ...


Cerebrospinal Fluid Levels Of Inflammation, Oxidative Stress And Nad+ Are Linked To Differences In Plasma Carotenoid Concentrations, Jade Guest, Ross Grant, Manohar Garg, Trevor A. Mori, Kevin D. Croft, Ayse Bilgin 2017 Australasian Research Institute

Cerebrospinal Fluid Levels Of Inflammation, Oxidative Stress And Nad+ Are Linked To Differences In Plasma Carotenoid Concentrations, Jade Guest, Ross Grant, Manohar Garg, Trevor A. Mori, Kevin D. Croft, Ayse Bilgin

Ross Grant

Background: The consumption of foods rich in carotenoids that possess significant antioxidant and inflammatory modulating properties has been linked to reduced risk of neuropathology. The objective of this study was to evaluate the relationship between plasma carotenoid concentrations and plasma and cerebrospinal fluid (CSF) markers of inflammation, oxidative stress and nicotinamide adenine dinucleotide (NAD+) in an essentially healthy human cohort. Methods: Thirty-eight matched CSF and plasma samples were collected from consenting participants who required a spinal tap for the administration of anaesthetic. Plasma concentrations of carotenoids and both plasma and cerebrospinal fluid (CSF) levels of NAD(H) and markers of ...


Developing Morally Sensitive Policy In The Nicu: Donation After Circulatory Determination Of Death, Michael van Manen, Nicole Kain 2017 University of Alberta Faculty of Medicine and Dentistry

Developing Morally Sensitive Policy In The Nicu: Donation After Circulatory Determination Of Death, Michael Van Manen, Nicole Kain

The Qualitative Report

Policy development is an important activity for the practice of healthcare. Policies, after all, may cultivate common practices and ensure that best available evidence is employed in clinical decision making. Qualitative research and individuals with expertise in qualitative research methods have much to offer policy makers. We were confronted with the situation of developing policy for donation after circulatory death (DCD) for our newborn intensive care program. Due the moral-ethical complexities surrounding DCD, and the limited experience with DCD in this context, we approached policy development from an iterative design perspective employing qualitative methods. We describe our experience in employing ...


Generation Y Health Professional Students’ Preferred Teaching And Learning Approaches: A Systematic Review, Caroline Mary Hills, Tracy Levett-Jones, Samuel Lapkin, Helen Warren-Forward 2017 National University of Ireland, Galway

Generation Y Health Professional Students’ Preferred Teaching And Learning Approaches: A Systematic Review, Caroline Mary Hills, Tracy Levett-Jones, Samuel Lapkin, Helen Warren-Forward

The Open Journal of Occupational Therapy

Generation Y or Millennials are descriptors for those born between 1982 and 2000. This cohort has grown up in the digital age and is purported to have different learning preferences from previous generations. Students are important stakeholders in identifying their preferred teaching and learning approaches in health professional programs. This study aimed to identify, appraise, and synthesize the best available evidence regarding the teaching and learning preferences of Generation Y health professional students. The review considered any objectively measured or self-reported outcomes of teaching and learning reported from Generation Y health professional student perspectives. In accordance with a previously published ...


Engaging Parents To Promote Children’S Nutrition And Health: Providers’ Barriers And Strategies In Head Start And Child Care Centers, Dipti Dev, Courtney Byrd-Williams, Samantha Ramsay, Brent A. McBride, Deepa Srivastava, Ashleigh May, Chrisa Arcan, Anna M. Adachi-Mejia 2017 University of Nebraska-Lincoln

Engaging Parents To Promote Children’S Nutrition And Health: Providers’ Barriers And Strategies In Head Start And Child Care Centers, Dipti Dev, Courtney Byrd-Williams, Samantha Ramsay, Brent A. Mcbride, Deepa Srivastava, Ashleigh May, Chrisa Arcan, Anna M. Adachi-Mejia

Faculty Publications, Department of Child, Youth, and Family Studies

Purpose: Using the Academy of Nutrition and Dietetics benchmarks as a framework, this study examined childcare providers’ (Head Start [HS], Child and Adult Care Food Program [CACFP] funded, and non-CACFP) perspectives regarding communicating with parents about nutrition to promote children’s health.

Design: Qualitative.

Setting: State-licensed center-based childcare programs.

Participants: Full-time childcare providers (n ¼ 18) caring for children 2 to 5 years old from varying childcare contexts (HS, CACFP funded, and non-CACFP), race, education, and years of experience.

Methods: In-person interviews using semi-structured interview protocol until saturation were achieved. Thematic analysis was conducted.

Results: Two overarching themes were barriers ...


The Experiences And Perceptions Of Behavioral Factors That Contribute To Successful Weight Loss In Male Bariatric Patients, Stephen P. Sowulewski 2017 Virginia Commonwealth University

The Experiences And Perceptions Of Behavioral Factors That Contribute To Successful Weight Loss In Male Bariatric Patients, Stephen P. Sowulewski

Theses and Dissertations

The purpose of this study was to examine the experiences and perceptions of behavioral factors that contribute to successful weight loss in male bariatric patients. By analyzing participant experiences and perceptions, this study contributes to a better understanding of which factors are most important in the postoperative phase of gastric bypass in males owing to successful weight loss. Although there is a tremendous amount of quantitative research within the bariatric population, there is a significant gap within the qualitative literature as it relates to male outcomes. As such, by conducting interviews with 10 postoperative male gastric bypass patients, this study ...


The Efficacy Of Biofeedback And Its Use Towards Adhd, Darius Witold Bieganski 2017 Claremont McKenna College

The Efficacy Of Biofeedback And Its Use Towards Adhd, Darius Witold Bieganski

CMC Senior Theses

Attention deficit hyperactivity disorder (ADHD) is a psychopathology commonly characterized by general inattentiveness and/or a lack of impulse control resulting in hyperactive tendencies. ADHD is estimated to cost the United States roughly $266 billion every year. ADHD is currently treated via medications, cognitive behavioral therapy, or more recently, neurofeedback. Neurofeedback – and biofeedback in general – is the process of providing a patient with information about autonomic bodily functions so that they may control said autonomic function. In the case of ADHD, neurofeedback focuses on reinforcing the behaviors and sensations associated with attentiveness. Currently however, neurofeedback systems are large and require ...


Improving Healthcare Provider Knowledge In Acute And Primary Transgender Health Needs: The Implementation Of A Clinical Education Program With Urgent Care And Emergency Room Staff And Providers, Tonia Lower 2016 Otterbein University

Improving Healthcare Provider Knowledge In Acute And Primary Transgender Health Needs: The Implementation Of A Clinical Education Program With Urgent Care And Emergency Room Staff And Providers, Tonia Lower

Doctoral Theses

The purpose of this project was to improve knowledge and identify personal bias and beliefs in the acute and primary healthcare needs of transgender persons, through the implementation of a clinical education program with healthcare providers and staff working within the urgent care and emergency department settings. The need for such a program exists due to the lack of suitable and accessible healthcare that may lead to misdiagnosis, delay of treatment and poor health outcomes. Including clinical education in the acute and primary healthcare needs of transgender persons that can be integrated into healthcare organizations may aid in the improvement ...


The Efects Of Parsimony Logic And Extended Parsimony Clustering On Protein Identification And Quantification In Shotgun Proteomics, Raviteja Madhira 2016 Oregon Health & Science University

The Efects Of Parsimony Logic And Extended Parsimony Clustering On Protein Identification And Quantification In Shotgun Proteomics, Raviteja Madhira

Scholar Archive

Shotgun proteomics is the most common mass spectrometry-based proteomics method for identifying and quantifying proteins present within a sample. Despite improvements in mass spectrometry tools, the issue dealing with inferring proteins and quantifying them from peptides still persists. The choice of protein sequence databases and the underlying genomic complexities of organisms are often considered sources of peptide degeneracy that lead to varying protein identifications and quantifications. In this thesis, the differences between four protein sequence database sources (Uniprot, NCBI, Ensembl, and IPI) were compared using redundant and non-redundant protein counts and shared and unique peptide counts for two higher eukaryotic ...


“In Principle We Have Agreement, But In Practice It Is A Bit More Difficult": Obtaining Organizational Buy-In To Patient-Centered Medical Home Transformation, Janelle Applequist, Michelle Miller-Day, Peter F. Cronholm, Robert Gabbay, Deborah S. Bowen 2016 Chapman University

“In Principle We Have Agreement, But In Practice It Is A Bit More Difficult": Obtaining Organizational Buy-In To Patient-Centered Medical Home Transformation, Janelle Applequist, Michelle Miller-Day, Peter F. Cronholm, Robert Gabbay, Deborah S. Bowen

Communication Faculty Articles and Research

The patient-centered medical home (PCMH) is a model of care that emphasizes the coordination of patient treatment among health care providers. Practice transformation to this model, however, presents a number of challenges. One of these challenges is getting the buy-in of all personnel to commit to making organizational changes in the journey to becoming a nationally recognized medical home. This study investigated internal messages of buy-in as communicated by practices transitioning to this type of care. Grounding itself in stakeholder theory, this study analyzed interviews with staff, administration, and practitioners from 20 medical practices in a mid-Atlantic state. The analysis ...


Fitness-To-Drive Screening Measure© : Constructing And Validating The Short Form, Shabnam Medhizadah 2016 The University of Western Ontario

Fitness-To-Drive Screening Measure© : Constructing And Validating The Short Form, Shabnam Medhizadah

Electronic Thesis and Dissertation Repository

The valid and reliable Fitness-to-Drive Screening Measure© (FTDS) is a free online proxy measure that screens for at-risk older drivers using 54 driving-related items. This secondary data analysis aims to construct and validate a short form FTDS, using 200 caregiver FTDS response sets and 200 older driver on-road assessment pass/fail outcomes. To construct the short form, exploratory factor analysis and classical test theory techniques were employed to determine the most interpretable factor model and the minimum number of items that might be used to predict fitness to drive. Next, receiver operating characteristics curves were generated to evaluate the concurrent ...


Synthesis, Characterization, And Application Of Monosized Mesoporous Silica Nanoparticle-Supported Lipid Bilayers For Targeted Therapeutic Delivery To Individual Cells, Paul Durfee 2016 University of New Mexico

Synthesis, Characterization, And Application Of Monosized Mesoporous Silica Nanoparticle-Supported Lipid Bilayers For Targeted Therapeutic Delivery To Individual Cells, Paul Durfee

Biomedical Engineering ETDs

Mesoporous silica nanoparticle (MSNP) supported-lipid bilayers, termed ‘protocells,’ represent a potentially transformative class of therapeutic and theranostic delivery vehicles. The field of targeted drug delivery poses considerable challenges that cannot be addressed with a single ‘magic bullet’. Consequently, the protocell has been designed as a modular platform composed of interchangeable biocompatible components. The mesoporous silica core can have variable size and shape to direct biodistribution and controlled pore size and surface chemistry to accommodate diverse cargos. The encapsulating supported lipid bilayer can be modified with targeting and trafficking ligands as well as polyethylene glycol (PEG) to effect selective binding, endosomal ...


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