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A Characterization Of The Dynamic Interaction Between The Pro-Apoptotic Protein Bid And The Mitochondrial Outer Membrane, Aisha Shamas-Din Ms. 2014 McMaster University

A Characterization Of The Dynamic Interaction Between The Pro-Apoptotic Protein Bid And The Mitochondrial Outer Membrane, Aisha Shamas-Din Ms.

Open Access Dissertations and Theses

Bcl-2 family of proteins regulate apoptosis at the level of the mitochondrial outer membrane (MOM) through both protein-protein and protein-membrane interactions. While the role of the membrane as the “locus of action” has been recognized, the detailed molecular mechanisms and the consequences of the interactions of Bcl-2 family members with the membrane are yet to be fully understood. The findings presented here focus on the dynamic interactions of Bcl-2 proteins, most notably tBid with the MOM, and their functional significance on mitochondrial outer membrane permeabilization. We show that the activation of tBid is a multi-step process that is regulated by ...


Unique Diagnostic Challenges Of Cushings From Large Bilateral Adrenal Adenoma And Mifepristone Utilization For Hypercortisolism Prior To Surgery, Vasudev G. Magaji MD, MS, Sarah Park DO, Maura Bucciarelli DO, Katie Mastoris DO, Scott Beman MD 2014 Lehigh Valley Health Network

Unique Diagnostic Challenges Of Cushings From Large Bilateral Adrenal Adenoma And Mifepristone Utilization For Hypercortisolism Prior To Surgery, Vasudev G. Magaji Md, Ms, Sarah Park Do, Maura Bucciarelli Do, Katie Mastoris Do, Scott Beman Md

Department of Medicine

No abstract provided.


Chemical Profiling And Biological Activity Of Two Tunicate-Associated Marine Bacteria, Lyubina Yankova 2014 University of Connecticut

Chemical Profiling And Biological Activity Of Two Tunicate-Associated Marine Bacteria, Lyubina Yankova

Honors Scholar Theses

Marine natural products have recently been an increasingly abundant source of novel antibiotics. Given that there is an increasing resistance to current drug therapies, finding new sources such as marine natural products is essential. Tunicate-associated marine bacteria can be a significant source of antibacterial compounds. Two tunicates of the species Eudistoma were collected from Portobelo National Park on the Salmedina Reef of Panama in the Caribbean Sea. Bacteria associated with the tunicate were isolated, cultured, extracted, and fractionated. Fractions were tested against an array of clinically relevant bacterial pathogens in the BioMAP assay. Two fractions MB0086E and MB0088E demonstrated activity ...


Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella 2014 Western Kentucky University

Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella

Masters Theses & Specialist Projects

HER2 overexpression in breast cancer tumors predicts lower overall survival. Because of the aggressive nature of HER2 tumors and the association with metastatic disease, the HER2 receptor holds great promise as a therapeutic target in metastatic breast cancer. We are developing small molecule inhibitors that bind to the ATP binding site of the tyrosine kinase domain in order to inhibit tyrosine auto-phosphorylation. This process controls biological pathways that mediate the cell growth. In normal cells this process is highly controlled. We are targeting the modification of the side chain of the hydroxy methyl group of 2-Hydroxy methyl-5,8-dimethoxy-1,4-naphthaquinone. These ...


Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham 2014 University of Rhode Island

Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham

Senior Honors Projects

A noted characteristic found in several neurodegenerative disorders, including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and bovine spongiform encephalopathy, is the accumulation of amyloid plaques in the brain. Amyloid plaques contain deposits of fibrillar aggregates of misfolded proteins that disrupt normal functionality in neurons. Certain variants of these misfolded proteins are self-replicating; these self-replicating amyloids are termed prions (for infectious protein). We are interested in how protein misfolding contributes to amyloid formation and how molecular chaperone proteins can change the formation of amyloid deposits. Chaperone proteins function by catalyzing the proper folding of other proteins, the refolding ...


The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn 2014 University of Connecticut

The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn

Honors Scholar Theses

Substantial evidence has shown that dopamine (DA), particularly in the nucleus accumbens (NAc), is involved in behavioral activation and effort-related processes, such as overcoming work related response costs. Interference with accumbens DA transmission through administration of the vesicular monoamine transportor-2 (VMAT-2) inhibitor tetrabenazine (TBZ) produces an alteration of response allocation in the concurrent FR5/chow choice procedure, biasing animals toward the lower effort alternative. It has been suggested that these drug-induced shifts in effort-related choice behavior seen in rodents are analogous to symptoms such as psychomotor retardation, anergia, and fatigue, which can be observed in people with depression and other ...


A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard 2014 East Tennessee State University

A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard

Undergraduate Honors Theses

In this study, three different chromatographic column chemistries (C18, Pentafluorophenyl (PFP), Hydrophilic Interaction Chromatography (HILIC)) were compared under optimal conditions to determine which stationary performed best in the separation and detection of a mixture of opioids using LC-MS. Furthermore, these stationary phases were examined in three different column technologies – traditional silica, porous shell, and porous polymer (PRP). The PRP column had the best peak shape for all 13 opioids and dominated for later-eluting compounds. In terms of column reproducibility, the Hamilton C18 column had the lowest %RSD values. The Kinetex HILIC produced the most theoretical plates and best resolution for ...


Nicotine And What Else?: Hplc Elution Optimization For The Analysis Of Alkaloids Found In Electronic Cigarettes, Jessica L. Murray 2014 University of Tennessee at Chattanooga

Nicotine And What Else?: Hplc Elution Optimization For The Analysis Of Alkaloids Found In Electronic Cigarettes, Jessica L. Murray

Honors Theses

Electronic cigarettes, or e-cigarettes, have been scrutinized by the Food and Drug Administration and other public health organizations for issues related to quality control and efficacy. Erratic nicotine delivery and numerous toxic compounds in refill solutions have been reported. The ultimate goal of this research is to add to the growing amount of knowledge regarding e-cigarette ingredient content, safety, and quality. Standards of the tobacco alkaloids nicotine, anabasine, cotinine, and myosmine were prepared and quantified using high performance liquid chromatography (HPLC). Various elution schemes were tested and adjusted for optimal analyte resolution, and a final elution scheme was developed to ...


Purple Urine Bag Syndrome: Regulation Of Pyrimidine Enzymes, Ashley N. Broadway 2014 University of Tennessee at Chattanooga

Purple Urine Bag Syndrome: Regulation Of Pyrimidine Enzymes, Ashley N. Broadway

Honors Theses

Purple Urine Bag Syndrome, PUBS, is a unique condition that shows an interesting discoloration of the urine from women who have a chronic catheter. This study focused on the regulation of enzyme activities to determine the effects that may create an environment where PUBS is seen in patients with catheters. In this study, the reductive pyrimidine pathway was used to read out the bacteria Pseudomonas aeruginosa ATCC 15692. This microorganism expresses a pathway that synthesizes indoxyl from tryptophan. The bacteria strains were grown using various carbon and nitrogen sources. Concentrations of acetonitrile at 2 mM and 10 mM, concentrations of ...


Syntheses Of Precursors To Fluorine-18 Labeled Pet Imaging Agents, Lindsay B. Boling 2014 University of Tennessee, Knoxville

Syntheses Of Precursors To Fluorine-18 Labeled Pet Imaging Agents, Lindsay B. Boling

University of Tennessee Honors Thesis Projects

No abstract provided.


Characterization Of Extraction Methods To Recover Phenolic-Rich Antioxidants From Blue Green Algae (Spirulina) Using Response Surface Approaches, Ahmad Salamatullah 2014 University of Nebraska - Lincoln

Characterization Of Extraction Methods To Recover Phenolic-Rich Antioxidants From Blue Green Algae (Spirulina) Using Response Surface Approaches, Ahmad Salamatullah

Dissertations & Theses in Food Science and Technology

Blue green algae (spirulina) is a dietary system that is widely consumed as a whole food or as a supplement in many Asian countries where populations are mostly unaffected by many of the diseases currently afflicting western societies, such as cancer, heart disease and arthiritis. Indeed, spirulina is a rich source of antioxidants with the phenolic compounds playing a significant role. As components of a complex dietary system, phenolic compounds can act alone or through synergistic mechanisms to impart a greater biologic effect than can be elicited by a sum of the individual parts. Therefore, an understanding of the antioxidative ...


Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle 2014 Liberty University

Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle

Senior Honors Theses

Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency. Mutated genes such as Fat Mass and Obesity Associated (FTO), Leptin (LEP), Leptin Receptor (LEPR), Melanocortin 4 Receptor (MC4R), Adiponectin C1Q and Collagen Domain Containing (ADIPOQ), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) all contribute to the development of childhood obesity. In the presence of high cholesterol caused by obesity, the genetic condition known as familial hypercholesterolemia is exacerbated. Familial hypercholesterolemia is caused by ...


The Effects Of Ocean Acidification And Eutrophication On The Growth, Lipid Composition And Toxicity Of The Marine Raphidophyte Heterosigma Akashiwo., Julia Rose Matheson 2014 Western University

The Effects Of Ocean Acidification And Eutrophication On The Growth, Lipid Composition And Toxicity Of The Marine Raphidophyte Heterosigma Akashiwo., Julia Rose Matheson

University of Western Ontario - Electronic Thesis and Dissertation Repository

Anthropogenic forcing, such as ocean acidification caused by rising carbon dioxide emissions, and eutrophication due to increased nutrient loadings in run-off, are causing major changes to the biogeochemistry of the oceans. As a consequence, coastal phytoplankton are susceptible to altered biogeochemical environments. This study examined the effect of a lower pH and increased levels of nutrients on the common coastal harmful alga, Heterosigma akashiwo. Growth rates, maximal cell yields, neutral lipid accumulation and toxicity of cells grown under various pH and nutrients regimes were measured. H. akashiwo growth was near maximal when grown at lower pH levels. There was a ...


Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell 2014 University of Tennessee, Knoxville

Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

The Exhibition of Undergraduate Research and Creative Achievement represents an event in which students involved in undergraduate research can present research projects at the University of Tennessee.


The Isolation Of A Red Pigment, Having Industrial And Medicinal Potential, Philip Strate 2014 Georgia State University

The Isolation Of A Red Pigment, Having Industrial And Medicinal Potential, Philip Strate

Georgia State Undergraduate Research Conference

No abstract provided.


Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin VanMouwerik, Merhawi Yigzaw, Reza Alavi 2014 Georgia State University

Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin Vanmouwerik, Merhawi Yigzaw, Reza Alavi

Georgia State Undergraduate Research Conference

No abstract provided.


Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney 2014 Georgia State University

Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney

Georgia State Undergraduate Research Conference

No abstract provided.


The Effects Of Picrotoxin And Ethanol On Crayfish Escape And Central Motor Pattern Neural Circuits, Rebecca Bierman, Nathan Hardcastle, Colin Istvan 2014 Georgia State University

The Effects Of Picrotoxin And Ethanol On Crayfish Escape And Central Motor Pattern Neural Circuits, Rebecca Bierman, Nathan Hardcastle, Colin Istvan

Georgia State Undergraduate Research Conference

No abstract provided.


Potential Therapies For Cystic Fibrosis: A Look At Cystic Fibrosis Transmembrane Conductance Regulator Correctors And Potentiators, Spencer G. Jones 2014 McMaster University

Potential Therapies For Cystic Fibrosis: A Look At Cystic Fibrosis Transmembrane Conductance Regulator Correctors And Potentiators, Spencer G. Jones

The Meducator

Cystic Fibrosis (CF) is an autosomal recessive genetic disorder that is caused by a mutation of the anion channel termed the cystic fibrosis transmembrane conductance regulator (CFTR). Treatment for CF has improved over time; however, many therapies focus only on alleviating symptoms as they occur. There have been recent advances in therapies that repair mutant CFTR, including the administration of small molecules called CFTR modulators. CFTR modulators fall under two categories: correctors that prevent early degradation of CFTR and potentiators that increase conductance of existing CFTR. This review discusses the advantages of repairing mutant CFTR, some recent advances in treatment ...


Medical Marijuana – Airing Out The Smoke Of Doubt, Aneesh Karir 2014 McMaster University

Medical Marijuana – Airing Out The Smoke Of Doubt, Aneesh Karir

The Meducator

On April 1, 2014, Canada will implement a drastically new set of regulations that will redefine the laws on the production and acquisition of medical marijuana, affecting over 35,000 patients nationwide. Patients will have to exclusively seek commercial vendors for medical marijuana and pay a much higher price compared to the costs of growing marijuana in their residences. This provides several benefits to the Canadian economy and protects against drug abuse, yet worries citizens and users who are trying to minimize costs. The Canadian government will require patients to obtain a prescription from a general physician, rather than a ...


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