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Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett 2017 East Tennessee State University

Synthesis And In-Vitro Cell Viability/Cytotoxicity Studies Of Novel Pyrrolobenzodiazepine Derivatives, John M. Jarrett

Undergraduate Honors Theses

Pyrrolobenzodiazepines (PBDs) are a group of naturally occurring compounds that were discovered in the cultures of Streptomyces in the 1960s. Some natural PBDs discovered in these cultures, such as anthramycin and sibiromycin, were shown to possess a broad spectrum of anti-tumor activity. Since cancer is still a leading cause of death globally, the development of novel anti-proliferative derivatives of PBDs is essential for human welfare worldwide. Further synthesis and structure-activity relationship (SAR) studies of the parent natural products and their tetracyclic analogs will lead to the discovery of drug candidates. In this work, thirteen PBD analogues were synthesized using no ...


Chitosan Microparticles: A Potential Therapeutic Intervention For Alzheimer's Disease With Cerebral Amyloid Angiopathy, Tanya L. Cupino, Matthew Zabel 2017 Loma Linda University

Chitosan Microparticles: A Potential Therapeutic Intervention For Alzheimer's Disease With Cerebral Amyloid Angiopathy, Tanya L. Cupino, Matthew Zabel

Loma Linda University Student Journal

Title: Chitosan Microparticles: A Potential Therapeutic Intervention for Alzheimer's Disease with Cerebral Amyloid Angiopathy

Introduction: Alzheimer’s Disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid beta (Ab) plaques in the brain parenchyma. Cerebral Amyloid Angiopathy (CAA), a common comorbidity with AD, is defined by Ab plaques form in the walls of the cerebral vessels. The past decade has seen significant progress in plaque diagnosis without similar therapeutic gains. In patients with CAA/AD the vascular plaques activate a part of innate immune system called the complement cascade, leading to lysis of cerebrovascular smooth-muscle cells (cvSMC) and vascular ...


Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi 2016 Trivedi Global Inc.

Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi

Mahendra Kumar Trivedi

Cellulose and its derivatives are used as potential matrices for biomaterials and tissue engineering applications. The objective of present research was to investigate the influence of biofield treatment on physical, chemical and thermal properties of ethyl cellulose (EC) and methyl cellulose (MC). The study was performed in two groups (control and treated). The control group remained as untreated, and biofield treatment was given to treated group. The biofield treated polymers are characterized by Fourier transform infrared spectroscopy (FT-IR), CHNSO analysis, X-ray diffraction study (XRD), Differential Scanning calorimetry (DSC), and thermogravimetric analysis (TGA). FT-IR analysis of treated EC showed downward shifting ...


Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi, Dahryn Trivedi 2016 Trivedi Global Inc.

Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi, Dahryn Trivedi

Mahendra Kumar Trivedi

Cellulose and its derivatives are used as potential matrices for biomaterials and tissue engineering applications. The objective of present research was to investigate the influence of biofield treatment on physical, chemical and thermal properties of ethyl cellulose (EC) and methyl cellulose (MC). The study was performed in two groups (control and treated). The control group remained as untreated, and biofield treatment was given to treated group. The biofield treated polymers are characterized by Fourier transform infrared spectroscopy (FT-IR), CHNSO analysis, X-ray diffraction study (XRD), Differential Scanning calorimetry (DSC), and thermogravimetric analysis (TGA). FT-IR analysis of treated EC showed downward shifting ...


Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott 2016 Chapman University

Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 ...


The Effects Of Tranexamic Acid On Mortality Rate In Trauma Patients Compared To Trauma Patients With No Tranexamic Acid Treatment, Bradley Earl Tolar 2016 University of Southern Mississippi

The Effects Of Tranexamic Acid On Mortality Rate In Trauma Patients Compared To Trauma Patients With No Tranexamic Acid Treatment, Bradley Earl Tolar

Doctoral Nursing Capstone Projects

Traumatic injury is the leading cause of death for many age groups. Traumatic accidents caused over 130,000 deaths in the United States in 2014. This DNP project studied the effects of Tranexamic acid on mortality rate in trauma patients. After the completion of a needs assessment at a local level II trauma center, a literature review was performed. The literature showed a decrease in mortality rate when patients were administered Tranexamic acid within 3 hours of injury with statistically significant statistics. Also, the data from the literature showed no correlation between vascular occlusive events and Tranexamic acid use in ...


Partial Amino Acid Sequence Of Lipid Transfer Protein From Fennel (Foeniculum Vulgare) Seeds, Hasan Al-Shiyab, Caroline Aziz 2016 Chapman University

Partial Amino Acid Sequence Of Lipid Transfer Protein From Fennel (Foeniculum Vulgare) Seeds, Hasan Al-Shiyab, Caroline Aziz

Student Research Day Abstracts and Posters

Fennel (Foeniculum vulgare) is a biennial Egyptian medicinal plant with an aromatic odor that belongs to the family Apiaceae (Umbelliferae). Fennel seeds are commonly used in traditional medicine, as they are known to have anti-inflammatory, anti-fungal and anti-cancerous activities. The major constituents of the fennel plant are sugars, minerals, essential fatty acids, proteins and fibers. Although, there are numerous studies on the medicinal properties of essential oils of the fennel seeds, but there is limited data reported on the proteins and peptides. The aims of this project are to fully characterize the primary structure of proteins and to determine their ...


Exploring Molecular Mechanisms Of Paradoxical Activation In The Braf Kinase Dimers: Atomistic Simulations Of Conformational Dynamics And Modeling Of Allosteric Communication Networks And Signaling Pathways, Amanda Tse, Gennady M. Verkhivker 2016 Chapman University

Exploring Molecular Mechanisms Of Paradoxical Activation In The Braf Kinase Dimers: Atomistic Simulations Of Conformational Dynamics And Modeling Of Allosteric Communication Networks And Signaling Pathways, Amanda Tse, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The recent studies have revealed that most BRAF inhibitors can paradoxically induce kinase activation by promoting dimerization and enzyme transactivation. Despite rapidly growing number of structural and functional studies about the BRAF dimer complexes, the molecular basis of paradoxical activation phenomenon is poorly understood and remains largely hypothetical. In this work, we have explored the relationships between inhibitor binding, protein dynamics and allosteric signaling in the BRAF dimers using a network-centric approach. Using this theoretical framework, we have combined molecular dynamics simulations with coevolutionary analysis and modeling of the residue interaction networks to determine molecular determinants of paradoxical activation. We ...


The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson 2016 Cedarville University

The Effects Of Apigenin On Cell Proliferation And Apoptosis In Glioblastoma Multiforme, Trevor Stump, Brittany Santee, Lauren Williams, Chelsae Heinze, Rachel Kunze, Samson Amos, Denise S. Simpson

Samson Amos, R.Ph., Ph.D.

Glioblastoma multiforme (GBM) is a WHO grade IV brain tumor. These tumors are highly proliferative, infiltrative, necrotic, angiogenic, and resistant to apoptosis. One major characteristic of GBM is the overexpression of epidermal growth factor receptor (EGFR), which leads to cell growth and proliferation when activated. GBM is very difficult to treat due to its location, heterogeneity, and invasiveness; an effective treatment is therefore needed. The use of flavonoids, which are natural compounds found in many fruits and vegetables, has been studied in the treatment of many different tumor types. Apigenin is a specific flavonoid that has previously been shown to ...


Reporting Risk: The Case Of Silicone Breast Implants, Dorothy Nelkin 2016 University of New Hampshire

Reporting Risk: The Case Of Silicone Breast Implants, Dorothy Nelkin

RISK: Health, Safety & Environment

Professor Nelkin finds journalists to be, if reluctantly, subject to influence and describes their uneasy relationship with scientists in filling a difficult role.


Lack Of Cross-Reactivity Allergy Following A Switch From Alirocumab To Evolocumab, Matthew D. Stryker, Michael Kane, Robert Busch 2016 Albany College of Pharmacy and Health Sciences

Lack Of Cross-Reactivity Allergy Following A Switch From Alirocumab To Evolocumab, Matthew D. Stryker, Michael Kane, Robert Busch

Excerpts in Pharmacy Research Journal

The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and gain-of-function mutations were first described in 2003. The gain-of-function mutations observed were associated with low-density lipoprotein-cholesterol (LDL-C) levels in the 400’s, in addition to premature cardiovascular disease. Subsequent loss-of-function experiments conducted in mice demonstrated marked reductions in plasma cholesterol levels in the absence of PCSK9. Physiologically, PCSK9 serves as a chaperone protein and functions to reduce low-density lipoprotein (LDL) receptor recycling; consequently, less LDL-C is removed from circulation and serum lipid concentrations become elevated. Inhibition of PCSK9 prevents LDL receptor degradation and preserves receptor recycling to the hepatocyte surface ...


A New Sv2a Ligand For Epilepsy, Michael A. Rogawski 2016 University of California - Davis

A New Sv2a Ligand For Epilepsy, Michael A. Rogawski

Michael A. Rogawski

Since the 1970s, racetams have been in use as cognitive enhancers. Levetiracetam was discovered to have antiseizure activity in animal models and was then found to bind to SV2A in synaptic and endocrine vesicles. Brivaracetam, an analog of levetiracetam, was identified in a medicinal chemistry campaign with the objective of discovering analogs with higher affinity at racetam-binding sites and greater antiseizure potency.


Profile Interview With Faculty Mentor Jane Krause, Elizabeth J. Dowell, Ashley M. Schinker 2016 Purdue University

Profile Interview With Faculty Mentor Jane Krause, Elizabeth J. Dowell, Ashley M. Schinker

Purdue Journal of Service-Learning and International Engagement

No abstract provided.


Book Review, Jennifer L. Frizzell 2016 University of New Hampshire

Book Review, Jennifer L. Frizzell

RISK: Health, Safety & Environment

Review of the following: THOMAS SZASZ, OUR RIGHT TO DRUGS: THE CASE FOR A FREE MARKET. (Praeger 1992) [164 pp.] Notes, bibliography, name index, notes, preface, subject index. LC: 91-30378; ISBN: 0-275-94216-3. [Cloth $19.95. P.O. Box 5007, Westwood CT 06881-9990.]


Book Review, Kristin S. Shrader-Frechette 2016 University of New Hampshire

Book Review, Kristin S. Shrader-Frechette

RISK: Health, Safety & Environment

Review of the following: ELAINE DRAPER, RiskY BUSINESS: GENETIC TESTING AND EXCLUSIONARY PRACTICES IN THE HAZARDOUS WORKPLACE. (Cambridge University Press 1991) [315 pp.] Index of names and subjects, glossary, notes, references. LC 90-28112; ISBN 0-521-37027-2 (cloth $49.50); ISBN 0-42248-5 (paper $15.95). [40 W. 20th St., New York NY 10011.]


Risk Perception And Drug Safety Evaluation, Ilan B. Vertinsky, Donald A. Wehrung 2016 University of New Hampshire

Risk Perception And Drug Safety Evaluation, Ilan B. Vertinsky, Donald A. Wehrung

RISK: Health, Safety & Environment

The authors present a Risk communication framework based on a survey of empirical research concerning public Risk perceptions. They also apply it to the area of pharmaceutical regulation to suggest more effective regulatory strategies.


The Changing Landscape Of Biosimilars In Rheumatology, Thomas Dorner, Vibeke Strand, Paul Cornes, Joao Goncalves, Laszlo Gulacsi, Jonathan Kay, Tore K. Kvien, Josef S. Smolen, Yoshiya Tanaka, Gerd R. Burmester 2016 Charite Universitätsmedizin

The Changing Landscape Of Biosimilars In Rheumatology, Thomas Dorner, Vibeke Strand, Paul Cornes, Joao Goncalves, Laszlo Gulacsi, Jonathan Kay, Tore K. Kvien, Josef S. Smolen, Yoshiya Tanaka, Gerd R. Burmester

Jonathan Kay

Biosimilars remain a hot topic in rheumatology, and some physicians are cautious about their application in the real world. With many products coming to market and a wealth of guidelines and recommendations concerning their use, there is a need to understand the changing landscape and the real clinical and health-economic potential offered by these agents. Notably, rheumatologists will be at the forefront of the use of biosimilar monoclonal antibodies/soluble receptors. Biosimilars offer cost savings and health gains for our patients and will play an important role in treating rheumatic diseases. We hope that these lower costs will compensate for ...


The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică 2016 Valparaiso University, Department of Psychology

The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică

Journal of Mind and Medical Sciences

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”

Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse ...


There Is A Trend Favoring Vancomycin Vs. Metronidazole In Treating Severe C. Difficile Infection, Dean D. Fouchia 2016 Wayne State University School of Medicine

There Is A Trend Favoring Vancomycin Vs. Metronidazole In Treating Severe C. Difficile Infection, Dean D. Fouchia

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Johnson S, Louie TJ, Gerding DN, et al. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin Infect Dis. 2014;59(3):345-354. doi: 10.1093/cid/ciu313


The Pesticidal Cry6aa Toxin From Bacillus Thuringiensis Is Structurally Similar To Hlye-Family Alpha Pore-Forming Toxins, Alexey Dementiev, Anand Sitaram, Yan Hu, Raffi V. Aroian, Colin Berry 2016 Shamrock Structures LLC

The Pesticidal Cry6aa Toxin From Bacillus Thuringiensis Is Structurally Similar To Hlye-Family Alpha Pore-Forming Toxins, Alexey Dementiev, Anand Sitaram, Yan Hu, Raffi V. Aroian, Colin Berry

Open Access Articles

BACKGROUND: The Cry6 family of proteins from Bacillus thuringiensis represents a group of powerful toxins with great potential for use in the control of coleopteran insects and of nematode parasites of importance to agriculture. These proteins are unrelated to other insecticidal toxins at the level of their primary sequences and the structure and function of these proteins has been poorly studied to date. This has inhibited our understanding of these toxins and their mode of action, along with our ability to manipulate the proteins to alter their activity to our advantage. To increase our understanding of their mode of action ...


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