Chemicals and Drugs Commons^™

What Are The Risks Of Oral Contraceptives In Patients With Cardiovascular Disease Risk Factors?, Kaitlin M. Love, Michelle D. Miller, Kenisha Pemberton, José E. Rodríguez Md

Family Medicine and Rural Health Faculty Publications

Women who smoke, have hypertension, hyperlipidemia, or factor V Leiden deficiency and take oral contraception (OC) are at increased risk of myocardial infarction (MI). Third-generation OCs and low-dose OCs are not associated with increased MI risk in women with or without other cardiovascular (CV) risk factors (SOR B, systematic review of cohort studies). OCs are contraindicated in women with preexisting congestive heart failure or CV disease, but may be used in otherwise healthy women with diabetes, hypertension, or hyperlipidemia (SOR C, evidence-based guidelines derived from consensus and expert opinion).

Should Coenzyme Q10 Be Used To Lower Blood Pressure In Asymptomatic Patients?, Daniella Barker, José E. Rodríguez Md

Family Medicine and Rural Health Faculty Publications

Coenzyme Q10 (CoQ10) may lower systolic and diastolic blood pressures in patients with primary hypertension, but is not recommended as an antihypertensive treatment (SOR: C, systematic review of low-quality RCTs using disease-oriented outcomes).

Molly: The Not So Convincing Truth Of Mdma, Alison Cromer

Sound Neuroscience: An Undergraduate Neuroscience Journal

This article discusses the schedule classification and effects of MDMA. The potential damage, therapeutic effects and reclassification of MDMA are examined in a new perspective that challenges past notions which lead to it's scheduling as a class one drug.

Molly: The Not So Convincing Truth Of Mdma, Alison Cromer

Sound Neuroscience Temporary

This article discusses the schedule classification and effects of MDMA. The potential damage, therapeutic effects and reclassification of MDMA are examined in a new perspective that challenges past notions which lead to it's scheduling as a class one drug.

Expression Of Itgb8 In Epicardial Adipose Tissue Is Highly And Directly Correlated With The Severity Of Coronary Atherosclerosis, Nancy Lee, Sarah M. Nicoloro, Juerg R. Straubhaar, Melinda Darrigo, Stanley Tam, Michael P. Czech, Timothy P. Fitzgibbons

Senior Scholars Program

Background: In patients with coronary artery disease (CAD), epicardial adipose tissue (EAT) has been shown to express increased levels of inflammatory cytokines (IL-1β, IL-6, MCP-1, TNFα) and decreased levels of anti-inflammatory and cardioprotective adipokines. However, it is not known whether or not inflammation in EAT is a primary cause or a secondary response to atherosclerosis. In order to better understand this pathophysiology, we tested the hypothesis that expression of certain genes in EAT would correlate with the degree of coronary atherosclerosis.

Purpose: The purpose of this study was to determine whether there is a difference in gene expression in epicardial ...

A Retrospective Analysis Of Opioid Consumption Among Different Orthopedic Surgeons For Total Joint Replacement, Costas J. Gioules, Hayden B. Rockson, Russell M. Flatto, Arnel J. Almeda, Anthony L. Schwagerl

Senior Scholars Program

Background: Throughout the world, baby boomers reaching their sixth, seventh, and eighth decade of life are requiring a significant number of joint replacements—hips and knees. Due to the increasing number of joint replacements, it is important to find a multi-modal approach (MMA) to control pain, reduce the amount of opioid consumption, and improve patient satisfaction.

Purpose: The purpose of this study was to evaluate the intraoperative, postoperative, and total opioid consumption of patients undergoing total hip and knee replacements in an effort to develop a multi-modal approach to decrease opioid consumption, minimize adverse effects secondary to narcotic administration, and ...

Stimulation Through Tlr4 Increases Fviii Inhibitor Formation In A Mouse Model Of Hemophilia A, Claire K. Holley

UT GSBS Dissertations and Theses (Open Access)

Hemophilia A is a clotting disorder caused by functional factor VIII (FVIII) deficiency. About 25% of patients treated with therapeutic recombinant FVIII develop antibodies (inhibitors) that render subsequent FVIII treatments ineffective. The immune mechanisms of inhibitor formation are not entirely understood, but circumstantial evidence indicates a role for increased inflammatory response, possibly via stimulation of Toll-like receptors (TLRs), at the time of FVIII immunization. I hypothesized that stimulation through TLR4 in conjunction with FVIII treatments would increase the formation of FVIII inhibitors. To test this hypothesis, FVIII K.O. mice were injected with recombinant human FVIII with or without concomitant ...

Comparison Of Methodologies For Synthesis Of 3-(Cyclopropylethynyl)Benzisothiazole 1,1-Dioxide, Rachel Lee Naramore

University of Tennessee Honors Thesis Projects

No abstract provided.

Oral Contraceptives, Stephenie G. Fortier

Senior Honors Papers

Cyclic oral contraceptive and continuous oral contraceptives have many similarities yet a few distinct differences. One of the major differences between cyclic and continuous oral contraceptives is that cyclic oral contraceptive pills have twenty one active pills and seven inactive pills versus the new continuous oral contraceptive pills which have 28 active pills and no inactive pills. However, though cyclic and continuous oral contraceptives do have a few differences, both types of oral contraceptives affect a woman’s body in similar ways. When choosing between cyclic and continuous oral contraceptives, it is important for women to be informed about the ...

Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne

Theses and Dissertations--Anatomy and Neurobiology

Due to the blood-brain barrier, delivery of many drugs to the brain has required intracranial surgery which is prone to complication. Here we show that Dopamine Neuron Stimulating Peptide 11 (DNSP-11), following non-invasive intranasal administration, protects dopaminergic neurons from a lesion model of Parkinson’s disease in the rat. A significant and dose-dependent increase in an index of dopamine turnover (the ratio of DOPAC to dopamine) was observed in the striatum of normal young adult Fischer 344 rats by whole-tissue neurochemistry compared to vehicle administered controls.

Among animals challenged with a moderate, unilateral 6-hydroxy-dopamine (6-OHDA) lesion of the substantia nigra ...

Synthesis And Stability Studies Of Prodrugs And Codrugs Of Naltrexone And 6-Β-Naltrexol, Joshua A. Eldridge

Theses and Dissertations--Pharmacy

The present study was divided between two different drug delivery goals, each involving naltrexone (NTX) or its active metabolite, 6-β-naltrexol (NTXOL). First, amino acid esters of NTX and NTXOL were prepared in order to test their candidacy for microneedle-enhanced transdermal delivery. Second, a 3-O-(-)-cytisine-naltrexone (CYT-NTX) codrug was prepared for screening as a potential oral delivery form of NTX and (-)-cytisine (CYT). The amino acid prodrugs were intended for the treatment of alcohol abuse, while the codrug was designed as a single agent for the treatment of alcoholism and tobacco-dependency co-morbidities. One hypothesis of this work was that prodrugs ...

Informationist Support For A Study Of The Role Of Proteases And Peptides In Cancer Pain, Alisa Surkis, Aileen Mccrillis, Richard Mcgowan, Jeffrey Williams, Brian L. Schmidt, Markus Hardt, Neil Rambo

Journal of eScience Librarianship

Two supplements were awarded to the New York University Health Sciences Libraries from the National Library of Medicine's informationist grant program. These supplements funded research support in a number of areas, including data management and bioinformatics, two fields that the library had recently begun to explore. As such, the supplements were of particular value to the library as a testing ground for these newer services.

This paper will discuss a supplement received in support of a grant from the National Institute of Dental and Craniofacial Research (PI: Brian Schmidt) on the role of proteases and peptides in cancer pain ...

Explaining The Supreme Court's Interest In Patent Law, Timothy R. Holbrook

IP Theory

No abstract provided.

Salinomycin: A Notch Signaling Antagonist - A Novel Way Of Targeting Cancer Stem Cells, Carlos U. Muzlera

The Meducator

Dr. Hassell’s research team aims to investigate the roles of therapeutically-relevant genes or gene signatures in the development of “tumour-initiating cells” or breast cancer stem cells. His research team also explores the effects of antagonistic compounds on certain regulatory receptor pathways using in vitro breast cancer cultures and transgenic mouse models. The following research focuses on validating the inhibitory effects of an anti-breast cancer stem cell agent, salinomycin, on downstream Notch signaling. It suggests the possibility of targeting cancer stem cells, the primary culprit in tumour initiation, chemoresistance, and metastasis, by inhibiting key regulatory pathways - such as Notch signaling ...

Combatting Dental Anxiety In Patients, Gretchen Osdoba

Natural Science Capstone Theses

Dental Anxiety is a highly debilitating condition that can keep people away from the dentist and from receiving critical care. This can lead to serious medical conditions that could have easily been prevented through proper dental care. The purpose of this paper is to describe the nature of dental fear and the different treatment options available. I will focus on helpful traits of dentists and the use of psychological treatments, nitrous oxide, anti-anxiety medications, and general anesthesia to reduce this fear. I will also discuss a comparison of a psychological treatment and an anti-anxiety medication as short-term and long-term treatment ...

Synthesis Of Near-Infrared Heptamethine Cyanine Dyes As Biological Imaging Agents, Jordan L. Malray

Georgia State Undergraduate Research Conference

No abstract provided.

Developing Pentamethine Cyanine Dyes For Photodynamic Therapy, Quoc Bao H. Nguyen

Georgia State Undergraduate Research Conference

No abstract provided.

Polyamine-Anthracene Conjugates: The Correlation Between Interaction With Dna, Pat Activity, And Cytotoxicity, Khoa T. Nguyen

Georgia State Undergraduate Research Conference

No abstract provided.

The Effects Of Internal And External Support On Drinking Outcomes After Receiving A Brief Intervention For Substance Abuse, Ashley D. Jackson

Georgia State Undergraduate Research Conference

No abstract provided.

Endocrine Imaging Using Near-Infrared Fluorescent Pentamethine Cyanine Dyes, Tyler Dost

Georgia State Undergraduate Research Conference

No abstract provided.