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Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors, Bruno Ramos-Molina, Adam N. Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg 2015 University of Maryland-Baltimore

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors, Bruno Ramos-Molina, Adam N. Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg

Pharmacy Faculty Articles and Research

Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity in vitro. In agreement, HIV-1 TAT47-57 reduced HT1080 cell migration, thought to be mediated by proprotein convertases, by 25%. In addition, cyclic polyarginine peptides containing hydrophobic moieties which have been previously used as transfection reagents also exhibited potent furin inhibition in vitro ...


Chemical Biology Of Protein Arginine Modifications In Epigenetic Regulation, Jakob Fuhrmann, Kathleen W. Clancy, Paul R. Thompson 2015 The Scripps Research Institute

Chemical Biology Of Protein Arginine Modifications In Epigenetic Regulation, Jakob Fuhrmann, Kathleen W. Clancy, Paul R. Thompson

Thompson Lab Publications

Review article on histone citrullination (arginine deimination), histone arginine methylation, and noncanonical histone arginine modifications.


Characterization Of The Role That Alternative Ribonucleotide Reductases Play In Restoring Replication In The Presence Of Hydroxyurea In Escherichia Coli, Michael Sadek 2015 Portland State University

Characterization Of The Role That Alternative Ribonucleotide Reductases Play In Restoring Replication In The Presence Of Hydroxyurea In Escherichia Coli, Michael Sadek

PSU McNair Scholars Online Journal

DNA replication is essential for cells to grow and divide. Ribonucleotide reductase is an essential enzyme that is responsible for the formation of deoxyribonucleotides that are used in DNA synthesis during replication. Hydroxyurea is a chemotherapeutic agent that is thought to work by specifically inhibiting the ribonuceotide reductase to prevent replication. However, recent studies in E. coli have shown that following an initial period of inhibition, DNA synthesis then recovers in the presence of hydroxyurea, suggesting that the mode of death and cellular response to hydroxyurea is more complex than originally proposed. The E.coli genome encodes three ribonucleotide reductases ...


Paper 22: Cloning And Characterization Of The Escherichia Coli Heptosyltransferase Iii: Exploring Substrate Specificity In Lipopolysaccaride Core Biosynthesis, Jagadesh Mudapaka, Erika A. Taylor 2015 Wesleyan University

Paper 22: Cloning And Characterization Of The Escherichia Coli Heptosyltransferase Iii: Exploring Substrate Specificity In Lipopolysaccaride Core Biosynthesis, Jagadesh Mudapaka, Erika A. Taylor

Erika A. Taylor, Ph.D.

Bacterial lipopolysaccharide (LPS) molecules are an important cell surface component that enables adhesion to surfaces and cell motility, amongst other functions. In Escherichia coli, there are multiple Heptosyltransferase enzymes involved in the biosynthesis of the core region of LPS. Here we describe the first ever cloning, expression, purification and characterization of Heptosyltransferase III (HepIII) from E. coli, which catalyzes the addition of an l-glycero-d-manno-heptose (Hep) residue to the growing LPS core via an α(1→7) bond. Inspired by results from our lab on the E. coli HepI, we assessed the catalytic efficiency with phospho-Hep2-Kdo2-Lipid A (PH2K2LA) and two deacylated ...


Determination Of Dioctyl Phthalate (Dehp) Concentration In Polyvinyl Chloride (Pvc) Plastic Parts Of Toothbrushes, Ghazal Sadeghi, Elham Ghaderian, Anne O'Connor 2015 Cleveland State University

Determination Of Dioctyl Phthalate (Dehp) Concentration In Polyvinyl Chloride (Pvc) Plastic Parts Of Toothbrushes, Ghazal Sadeghi, Elham Ghaderian, Anne O'Connor

The Downtown Review

Phthalates are chemicals that are widely used in daily products and polyvinyl chloride (PVC) plastics, mainly because of their ability to enhance flexibility and durability. The presence of phthalates in various products contributes to the substantial exposure that all consumers may experience. Continuity in phthalate exposure has several side effects, including endocrine disruption, neurological damage, asthma, hormonal imbalances, obesity, infertility, genital defects, and testicular cancer. The purpose of this research experiment was to determine the Dioctyl phthalate (DEHP) concentration of PVC plastic parts of toothbrushes. The method used to conduct the experiment was Gas Chromatography/Mass Spectrometry. The result showed ...


Synthesis And Characterization Of A New Peptide Prodrug Of Glucosamine With Enhanced Gut Permeability, Hamed Gilzad Kohan, Kamaljit Kaur, Fakhreddin Jamali 2015 University of Alberta

Synthesis And Characterization Of A New Peptide Prodrug Of Glucosamine With Enhanced Gut Permeability, Hamed Gilzad Kohan, Kamaljit Kaur, Fakhreddin Jamali

Pharmacy Faculty Articles and Research

The aim of this study was to synthesize a peptide prodrug of glucosamine (GlcN) with increased gut permeability through the gut peptide transporter 1 (PepT1). Glycine-Valine ester derivative of GlcN (GVG) was synthesised using solid phase synthesis followed by characterization and evaluation of its physicochemical and intestinal stability. In addition, GVG was evaluated for its ability to be biotransformed to GlcN in the liver homogenate. In vitro absorption of the new prodrug through everted rat gut was also assessed. GVG demonstrated significant and meaningful increased gut permeability as compared with GlcN. It showed favorable stability in the gut and a ...


Argatroban For The Treatment Of Heparin-Induced Thrombocytopenia In End Stage Renal Disease And Acute Kidney Injury, Lindsey Elmore PharmD, BCPS, Leslie A. Hamilton Pharm.D., BCPS 2015 University of Tennessee Health Science Center

Argatroban For The Treatment Of Heparin-Induced Thrombocytopenia In End Stage Renal Disease And Acute Kidney Injury, Lindsey Elmore Pharmd, Bcps, Leslie A. Hamilton Pharm.D., Bcps

Tennessee Medicine E-Journal

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Cave Cyanobacteria Showing Antibacterial Activity, Vasiliki Lamprinou, Kyriaki Tryfinopoulou, Emmanuel N. Velonakis, Alkiviadis Vatopoulos, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Adriani Pantazidou, Athena Economou-Amilli 2015 University of Athens, Faculty of Biology, Department of Ecology & Systematics

Cave Cyanobacteria Showing Antibacterial Activity, Vasiliki Lamprinou, Kyriaki Tryfinopoulou, Emmanuel N. Velonakis, Alkiviadis Vatopoulos, Smaragdi Antonopoulou, Elizabeth Fragopoulou, Adriani Pantazidou, Athena Economou-Amilli

International Journal of Speleology

Cave Cyanobacteria - thriving in an ‘extreme’ environment with interesting species biodiversity - are supposed to be a potential source of bioactive compounds. Lipid extracts from pure cultures of two recently established Cyanobacteria from Greek caves, Toxopsis calypsus and Phormidium melanochroun, were used for antibacterial screening against human pathogenic bacteria (reference and clinical isolates). Antimicrobial Susceptibility testing for both taxa was carried out using the disc-diffusion (Kirby Bauer) method, while preliminary data applying the standard broth microdilution method for the determination of the Minimal Inhibitory Concentration (MIC) are given only for T. calypsus. Antibacterial activity was demonstrated against the Gram-positive clinical and ...


The Characterization Of Amyloid Fibrils And Novel Synthetic Heparin-Binding Peptides Binding To Cell Surfaces, Nicole Marie Hackenbrack 2015 University of Tennessee, Knoxville

The Characterization Of Amyloid Fibrils And Novel Synthetic Heparin-Binding Peptides Binding To Cell Surfaces, Nicole Marie Hackenbrack

University of Tennessee Honors Thesis Projects

No abstract provided.


Effects Of Different Brands Of Coffee On The Transcriptional Activity Of Drosophila Cyp6a8 Gene Promoter, Marie Ashley Scott 2015 University of Tennessee, Knoxville

Effects Of Different Brands Of Coffee On The Transcriptional Activity Of Drosophila Cyp6a8 Gene Promoter, Marie Ashley Scott

University of Tennessee Honors Thesis Projects

No abstract provided.


Evaluation Of Bde-47 And -99 Lipid Modulating Effects In Hepg2 Human Carcinoma Cells, Eileen A. Holovac 2015 University of Rhode Island

Evaluation Of Bde-47 And -99 Lipid Modulating Effects In Hepg2 Human Carcinoma Cells, Eileen A. Holovac

Senior Honors Projects

Non-alcoholic fatty liver disease (NAFLD) is becoming a significantly more common problem in today’s society, affecting up to 25% of people in the United States as reported by the American Liver Foundation. According to the American Association of the Study of Liver Diseases, NAFLD is the buildup of fat in the liver that is not caused by secondary factors such as alcohol consumption, hereditary disorders, or the use of steatogenic medication such as amioderone. A liver is considered fatty when 5-10% of the liver’s weight is fat. The progression of NAFLD can lead to cirrhosis, liver cancer, or ...


Detection Of Igg4-Specific Autoantibodies In Rheumatoid Arthritis Serum Samples, Azra Borogovac, Youmna Lahoud, Janice Weaver, Sheldon M. Cooper, Mercedes Rincon, Jonathan Kay, Ellen M. Gravallese 2015 University of Massachusetts Medical School

Detection Of Igg4-Specific Autoantibodies In Rheumatoid Arthritis Serum Samples, Azra Borogovac, Youmna Lahoud, Janice Weaver, Sheldon M. Cooper, Mercedes Rincon, Jonathan Kay, Ellen M. Gravallese

Senior Scholars Program

Background: Rheumatoid arthritis (RA) is a chronic multi-system autoimmune disease characterized by inflammatory synovitis. Autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) have been implicated in the pathogenesis of RA, and are currently important criteria for diagnosis within the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria.1 Yet, many patients diagnosed with RA do not have measurable circulating ACPA or RF which may result in delayed diagnosis and treatment. After IgG1, IgG4 is the second most predominant isotype among ACPA and RF; however it is not detected in currently available diagnostic ...


Effects Of Bpa And Alternatives On Human Health Concerning The Nflpa, Jeremy Martell 2015 St. John Fisher College

Effects Of Bpa And Alternatives On Human Health Concerning The Nflpa, Jeremy Martell

Biology Undergraduate

No abstract provided.


Obafluorin: A Potential Inhibitor Of Serine Hydroxymethyl Trasferase, Neha Prasad 2015 Washington University in St Louis

Obafluorin: A Potential Inhibitor Of Serine Hydroxymethyl Trasferase, Neha Prasad

Undergraduate Research Symposium Posters & Abstracts

In the golden age of drug discovery, scientists turned to nature to find and emulate molecules with pharmacological activity. The beta-lactam ring in penicillin has proven to be one of the most important classes of antibiotics of the last century. The molecule I am studying, obafluorine, was isolated from Pseudomonas fluorescens and has a beta-lactone ring in its structure—a close relative of the beta-lactam ring in Penicillin. Obafluorin was isolated as a broad-spectrum antibacterial and antifungal agent that could have therapeutic properties, but its cellular target is still unknown. The Wencewicz Lab in the WUSTL Department of Chemistry is ...


Flavour Chemicals In Electronic Cigarette Fluids, Peyton A. Tierney, Clarrissa D. Karpinski, Jessica E. Brown, Wentai Luo, James F. Pankow 2015 Portland State University

Flavour Chemicals In Electronic Cigarette Fluids, Peyton A. Tierney, Clarrissa D. Karpinski, Jessica E. Brown, Wentai Luo, James F. Pankow

Chemistry Faculty Publications and Presentations

Background: Most e-cigarette liquids contain flavour chemicals. Flavour chemicals certified as safe for ingestion by the Flavor Extracts Manufacturers Association may not be safe for use in e-cigarettes. This study identified and measured flavour chemicals in 30 e-cigarette fluids.

Methods: Two brands of single-use e-cigarettes were selected and their fluids in multiple flavour types analysed by gas chromatography/mass spectrometry. For the same flavour types, and for selected confectionary flavours (eg, bubble gum and cotton candy), also analysed were convenience samples of e-cigarette fluids in refill bottles from local ‘vape’ shops and online retailers.

Results: In many liquids, total flavour ...


Exploration Of Putative Mitochondrial Gene Expression In Crithidia Fasciculata As A Model For Pathogenic Trypanosomes Causing Human Disease, Baylye Boxall, Nadjean Sagesse 2015 Georgia State University

Exploration Of Putative Mitochondrial Gene Expression In Crithidia Fasciculata As A Model For Pathogenic Trypanosomes Causing Human Disease, Baylye Boxall, Nadjean Sagesse

Georgia State Undergraduate Research Conference

No abstract provided.


Evaluation Of Polyamine-Anthracene Conjugates As Dna Ligands: A Potential Anti-Cancer Agent, Khoa T. Nguyen, Sunhwa Joung, Jennifer J. Archer, Otto Phanstiel IV, Kathryn B. Grant 2015 Georgia State University

Evaluation Of Polyamine-Anthracene Conjugates As Dna Ligands: A Potential Anti-Cancer Agent, Khoa T. Nguyen, Sunhwa Joung, Jennifer J. Archer, Otto Phanstiel Iv, Kathryn B. Grant

Georgia State Undergraduate Research Conference

No abstract provided.


High Potency Eugeroics-- Wake-Promoting Agents Beyond Modafinil, Joseph Yoham 2015 California Polytechnic State University - San Luis Obispo

High Potency Eugeroics-- Wake-Promoting Agents Beyond Modafinil, Joseph Yoham

Biomedical Eng/General Eng.

Modafinil (Provigil) belongs to a new pharmaceutical class known as eugeroics— wake-promoting agents. Directly enhancing conductance across neuronal membranes, modafinil, amplifies presynaptic Na/Ca influx; resultant widespread depolarization of cortical interneurons could theoretically allow transient, voltage-dependent inhibition of monoamine reuptake- resembling action of conventional stimulants, minus the stereotypy, euphoria, and locomotor effects. This literature review presents a hypothesized mechanism of action, consolidates research of modafinil analogues and hybridizes a novel compound in search of a next generation molecule.


Drug Testing Government Assistance Recipients, Justin Galles 2015 Omaha North High Magnet School

Drug Testing Government Assistance Recipients, Justin Galles

Nebraska College Preparatory Academy Senior Capstone Projects

Eligibility for government assistance is based on income levels and is generally given to single parents and lower income families. Government assistance programs like welfare, SNAP (food stamps), and unemployment all help support people who have less income than what is necessary to support themselves and or their families. Programs like welfare and unemployment give checks that can be cashed and used at the discretion of the recipient. Who is to say recipients aren’t spending tax payer dollars on illegal drugs? People aren’t going to admit to government officials that they use illegal drugs so to be sure ...


Prostate Tumorigenesis Induced By Pten Deletion Involves Estrogen Receptor Beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, Arthur M. Mercurio 2015 University of Massachusetts Medical School

Prostate Tumorigenesis Induced By Pten Deletion Involves Estrogen Receptor Beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, Arthur M. Mercurio

Molecular, Cell and Cancer Biology Publications

The role of ERbeta in prostate cancer is unclear, although loss of ERbeta is associated with aggressive disease. Given that mice deficient in ERbeta do not develop prostate cancer, we hypothesized that ERbeta loss occurs as a consequence of tumorigenesis caused by other oncogenic mechanisms and that its loss is necessary for tumorigenesis. In support of this hypothesis, we found that ERbeta is targeted for repression in prostate cancer caused by PTEN deletion and that loss of ERbeta is important for tumor formation. ERbeta transcription is repressed by BMI-1, which is induced by PTEN deletion and important for prostate tumorigenesis ...


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