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A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard 2014 East Tennessee State University

A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard

Undergraduate Honors Theses

In this study, three different chromatographic column chemistries (C18, Pentafluorophenyl (PFP), Hydrophilic Interaction Chromatography (HILIC)) were compared under optimal conditions to determine which stationary performed best in the separation and detection of a mixture of opioids using LC-MS. Furthermore, these stationary phases were examined in three different column technologies – traditional silica, porous shell, and porous polymer (PRP). The PRP column had the best peak shape for all 13 opioids and dominated for later-eluting compounds. In terms of column reproducibility, the Hamilton C18 column had the lowest %RSD values. The Kinetex HILIC produced the most theoretical plates and best resolution for ...


Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell 2014 University of Tennessee, Knoxville

Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

The Exhibition of Undergraduate Research and Creative Achievement represents an event in which students involved in undergraduate research can present research projects at the University of Tennessee.


The Isolation Of A Red Pigment, Having Industrial And Medicinal Potential, Philip Strate 2014 Georgia State University

The Isolation Of A Red Pigment, Having Industrial And Medicinal Potential, Philip Strate

Georgia State Undergraduate Research Conference

No abstract provided.


Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin VanMouwerik, Merhawi Yigzaw, Reza Alavi 2014 Georgia State University

Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin Vanmouwerik, Merhawi Yigzaw, Reza Alavi

Georgia State Undergraduate Research Conference

No abstract provided.


Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney 2014 Georgia State University

Development Of A Safe And Efficient Near-Infrared Diagnostic Method For Alzheimer's Disease, Joseph Tawney

Georgia State Undergraduate Research Conference

No abstract provided.


The Effects Of Picrotoxin And Ethanol On Crayfish Escape And Central Motor Pattern Neural Circuits, Rebecca Bierman, Nathan Hardcastle, Colin Istvan 2014 Georgia State University

The Effects Of Picrotoxin And Ethanol On Crayfish Escape And Central Motor Pattern Neural Circuits, Rebecca Bierman, Nathan Hardcastle, Colin Istvan

Georgia State Undergraduate Research Conference

No abstract provided.


Potential Therapies For Cystic Fibrosis: A Look At Cystic Fibrosis Transmembrane Conductance Regulator Correctors And Potentiators, Spencer G. Jones 2014 McMaster University

Potential Therapies For Cystic Fibrosis: A Look At Cystic Fibrosis Transmembrane Conductance Regulator Correctors And Potentiators, Spencer G. Jones

The Meducator

Cystic Fibrosis (CF) is an autosomal recessive genetic disorder that is caused by a mutation of the anion channel termed the cystic fibrosis transmembrane conductance regulator (CFTR). Treatment for CF has improved over time; however, many therapies focus only on alleviating symptoms as they occur. There have been recent advances in therapies that repair mutant CFTR, including the administration of small molecules called CFTR modulators. CFTR modulators fall under two categories: correctors that prevent early degradation of CFTR and potentiators that increase conductance of existing CFTR. This review discusses the advantages of repairing mutant CFTR, some recent advances in treatment ...


Medical Marijuana – Airing Out The Smoke Of Doubt, Aneesh Karir 2014 McMaster University

Medical Marijuana – Airing Out The Smoke Of Doubt, Aneesh Karir

The Meducator

On April 1, 2014, Canada will implement a drastically new set of regulations that will redefine the laws on the production and acquisition of medical marijuana, affecting over 35,000 patients nationwide. Patients will have to exclusively seek commercial vendors for medical marijuana and pay a much higher price compared to the costs of growing marijuana in their residences. This provides several benefits to the Canadian economy and protects against drug abuse, yet worries citizens and users who are trying to minimize costs. The Canadian government will require patients to obtain a prescription from a general physician, rather than a ...


Establishing A Floor: Minimum Remediation Requirements For Meth Labs, Chelsea Bobo 2014 College of William & Mary Law School

Establishing A Floor: Minimum Remediation Requirements For Meth Labs, Chelsea Bobo

William & Mary Environmental Law and Policy Review

No abstract provided.


Vibrational Spectroscopy: Disease Diagnostics And Beyond, Hugh J. Byrne, Kamila Ostrowska, Haq Nawaz, Jennifer Dorney, Aidan D. Meade, Franck Bonnier, Fiona M. Lyng 2014 Dublin Institute of Technology

Vibrational Spectroscopy: Disease Diagnostics And Beyond, Hugh J. Byrne, Kamila Ostrowska, Haq Nawaz, Jennifer Dorney, Aidan D. Meade, Franck Bonnier, Fiona M. Lyng

Books/Book Chapters

Summary

This chapter outlines some developments in the applications of vibrational spectroscopy for disease diagnostics and demonstrates how the applications of the spectroscopic techniques can be extended to the analysis and evaluation of disease aetiology and the mechanisms of interaction and the cellular and subcellular responses to, for example chemotherapeutic agents and nanoparticles. The primary emphasis is on Raman spectroscopy, although some examples are based on infrared absorption spectroscopy. The studies presented are chosen to illustrate how a range of multivariate analytical techniques can be employed to maximize the potential benefits of the complex spectral information obtained from tissue or ...


Investigation Of Commercial Milk Enzyme-Linked Immunosorbent Assay (Elisa) Kits: Specificity And Utility For Residues Of Foods Subjected To Proteolysis During Processing, Katherine O. Ivens 2013 University of Nebraska - Lincoln

Investigation Of Commercial Milk Enzyme-Linked Immunosorbent Assay (Elisa) Kits: Specificity And Utility For Residues Of Foods Subjected To Proteolysis During Processing, Katherine O. Ivens

Dissertations & Theses in Food Science and Technology

Analytical methods, such as enzyme-linked immunosorbent assays (ELISA), are used to detect and quantify residues from allergenic sources in food products. However, ELISAs have not been validated for use in foods that have been exposed to proteolysis. This thesis explores the specificities, sensitivities, and capabilities of commercially-available milk ELISA kits for detecting milk residues in cheeses that have undergone varying degrees of proteolysis.

The specificity, accuracy, and consistency of twelve commercially-available milk ELISA kits for individual milk proteins and commonly used milk-derived ingredients, including α-,β-, and κ-casein, β-lactoglobulin, α-lactalbumin, non-fat dry milk, sodium caseinate, and whey protein concentrate were ...


Characterization Of Prophylactic Antiemetic Regimens In Pediatric Patients Receiving Moderately And Highly Emetogenic Chemotherapy, Jessica Degiacomo PharmD, Kristin M. Held PharmD, BCOP 2013 Lehigh Valley Health Network

Characterization Of Prophylactic Antiemetic Regimens In Pediatric Patients Receiving Moderately And Highly Emetogenic Chemotherapy, Jessica Degiacomo Pharmd, Kristin M. Held Pharmd, Bcop

Department of Pharmacy

No abstract provided.


Proconvulsant Actions Of Intrahippocampal Botulinum Neurotoxin B In The Rat, Sonja Bröer, Dorota Zolkowska, Manuela Gernert, Michael A. Rogawski 2013 SelectedWorks

Proconvulsant Actions Of Intrahippocampal Botulinum Neurotoxin B In The Rat, Sonja Bröer, Dorota Zolkowska, Manuela Gernert, Michael A. Rogawski

Michael A. Rogawski

Botulinum neurotoxins (BoNTs) may affect the excitability of brain circuits by inhibiting neurotransmitter release at central synapses. There is evidence that local delivery of BoNT serotypes A and E, which target synaptosomal-associated protein 25, a component of the release machinery specific to excitatory synapses, can inhibit seizure generation. BoNT serotype B (BoNT/B) targets VAMP2, which is expressed in both excitatory and inhibitory terminals. Here we assessed the effects of unilateral intrahippocampal infusion of BoNT/B in the rat on intravenous pentylenetetrazol (PTZ) seizure thresholds, and on the expression of spontaneous behavioral and electrographic seizures. Infusion of BoNT/B (500 ...


Leica Microscope Gpu Deconvolution Stellaris Fish Dataset #1, George McNamara 2013 The University of Texas

Leica Microscope Gpu Deconvolution Stellaris Fish Dataset #1, George Mcnamara

George McNamara

McNamara 20131101Fri Leica widefield microscope CUDA Deconvolution Stellaris FISH probe cultured cells dataset #1.zip

A text file in the zip archive has experiment details. I am posting this online so that researchers - whether academic or commercial - can evaluate the acquired data, the Bruce and Butte 2013 Optics Express ( http://www.opticsinfobase.org/oe/fulltext.cfm?uri=oe-21-4-4766 ) deconvolution result (note: I may not have used optimal settings), and to compare these deconvolution results to other methods. If anyone generates alternative spatial deconvolution output, such as from: * SVI Huygens * Media Cy AutoQuant * Agard's ER-Decon (Arigovindan 2013 PNAS) * Vicidomini SGP ...


Bio-Identical Hormone Therapy: Understanding Women's Decision-Making Process And Family Physicians' Views, Lemmese AlWatban 2013 Western University

Bio-Identical Hormone Therapy: Understanding Women's Decision-Making Process And Family Physicians' Views, Lemmese Alwatban

University of Western Ontario - Electronic Thesis and Dissertation Repository

This thesis explored women’s and family physicians’ experiences with Bio-identical Hormone Therapy (BHT). It aimed to develop a deeper understanding of women’s decision-making process in choosing this therapeutic modality, and the influence family physicians may have on this process. To capture the phenomenon under study, two complementary and sequential qualitative studies were conducted. The studies involved in-depth interviews with women using BHT and family physicians that care for this population. The collective findings of both studies demonstrated the complexity of menopause care. The findings illuminated the major factors involved in women’s BHT decision-making process. It also offered ...


The Use Of Near Infrared And Microwave Sensing For On-Line Real Time Monitoring Of Moisture Content And Composition Of Powder Blend, Ryan V. McDonnell, Anshu Gupta, John Austin, Michael T. Harris, Gintaras V. Reklaitis 2013 Purdue University

The Use Of Near Infrared And Microwave Sensing For On-Line Real Time Monitoring Of Moisture Content And Composition Of Powder Blend, Ryan V. Mcdonnell, Anshu Gupta, John Austin, Michael T. Harris, Gintaras V. Reklaitis

The Summer Undergraduate Research Fellowship (SURF) Symposium

Online process analytics has been a topic of interest by pharmaceutical companies as a method of determining how operating parameters affect the final quality of their products. One form of online process analytics that has been found to be effective is microwave sensing. While it has been found that microwave resonance sensing can be used to measure parameters such as moisture content and density, it has yet to be discovered if such sensors have the ability to measure changes in content uniformity of raw materials pharmaceutical companies use. Data was collected using a spin riffler fitted with a microwave sensor ...


Cellular Uptake Mechanism Of Paclitaxel Nanocrystals, Iris K. Archer, Zhaohui Wang, Tonglei Li 2013 Purdue University

Cellular Uptake Mechanism Of Paclitaxel Nanocrystals, Iris K. Archer, Zhaohui Wang, Tonglei Li

The Summer Undergraduate Research Fellowship (SURF) Symposium

Therapeutic options for metastasized human cancer in current practice remain limited and, sadly, there is no cure for metastatic cancer. The typical approach, chemotherapy, has both low efficacy due to poor drug solubility, and cytotoxic side effects to healthy tissue when delivered indiscriminately. To address both of these issues, we are pursuing the use of nanocrystal formulations of current chemotherapeutic agents as delivery platforms. Herein, we have studied cellular uptake mechanisms in cancer cells of nanocrystals of a chemotherapeutic agent, paclitaxel. Our goal in this study is to determine whether the nanocrystals can be taken up via endocytosis, especially when ...


Non-Mass Transfer Limited Crystal Growth, Ryan J. Smyth, Caitlin Schram, Stephen P. Beaudoin 2013 Purdue University

Non-Mass Transfer Limited Crystal Growth, Ryan J. Smyth, Caitlin Schram, Stephen P. Beaudoin

The Summer Undergraduate Research Fellowship (SURF) Symposium

There are many different active pharmaceutical ingredients (APIs) that have been discovered in research labs all around the world that can be used to treat and cure patients with a variety of different ailments. The challenge with these APIs in treatments is that they are not soluble in water, thus they low absorption into the blood stream (bio-availability). The key to making these APIs more bio-available is to understand how they grow as crystals and drop out of the aqueous solutions. One of the ways these APIs were made more bio-available is to render them amorphous and suspend them in ...


Whey Protein Supplements For Bodybuilding, Lissa Coffey 2013 SelectedWorks

Whey Protein Supplements For Bodybuilding, Lissa Coffey

LissaCoffey

Most bodybuilders take whey protein to boost muscle growth after they workout. Some also include whey protein based snacks, shakes and ...Protein milkshakes, made from protein powder (center) and ... For bodybuilders whey protein provides amino acids used to aid ...Whey protein powder is a top quality and fast acting protein that's perfect immediately after your workout for optimal absorption .Whey protein supplements are best muscle-building pre & post workout supplements for any fitness goals: lean muscle mass, bulking up.


Specific Increase In Mdr1 Mediated Drug-Efflux In Human Brain Endothelial Cells Following Co-Exposure To Hiv-1 And Saquinavir, Upal Roy, Christine Bulot, Kerstin Honer zu Bentrup, Debasis Mondal 2013 Florida International University

Specific Increase In Mdr1 Mediated Drug-Efflux In Human Brain Endothelial Cells Following Co-Exposure To Hiv-1 And Saquinavir, Upal Roy, Christine Bulot, Kerstin Honer Zu Bentrup, Debasis Mondal

HWCOM Faculty Publications

Persistence of HIV-1 reservoirs within the Central Nervous System (CNS) remains a significant challenge to the efficacy of potent anti-HIV-1 drugs. The primary human Brain Microvascular Endothelial Cells (HBMVEC) constitutes the Blood Brain Barrier (BBB) which interferes with anti-HIV drug delivery into the CNS. The ATP binding cassette (ABC) transporters expressed on HBMVEC can efflux HIV-1 protease inhibitors (HPI), enabling the persistence of HIV-1 in CNS. Constitutive low level expression of several ABC-transporters, such as MDR1 (a.k.a. P-gp) and MRPs are documented in HBMVEC. Although it is recognized that inflammatory cytokines and exposure to xenobiotic drug substrates (e ...


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