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Klf4-Sqstm1/P62-Associated Prosurvival Autophagy Contributes To Carfilzomib Resistance In Multiple Myeloma Models., Irene Riz, Teresa S. Hawley, Robert G. Hawley 2015 George Washington University

Klf4-Sqstm1/P62-Associated Prosurvival Autophagy Contributes To Carfilzomib Resistance In Multiple Myeloma Models., Irene Riz, Teresa S. Hawley, Robert G. Hawley

Anatomy and Regenerative Biology Faculty Publications

Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. Because of a high rate of immunoglobulin synthesis, the endoplasmic reticulum of MM cells is subjected to elevated basal levels of stress. Consequently, proteasome inhibitors, which exacerbate this stress by inhibiting ubiquitin-proteasome-mediated protein degradation, are an important new class of chemotherapeutic agents being used to combat this disease. However, MM cells still develop resistance to proteasome inhibitors such as carfilzomib. Toward this end, we have established carfilzomib-resistant derivatives of MM cell lines. We found that resistance to carfilzomib was associated with elevated levels of prosurvival autophagy, and Kruppel-like factor 4 ...


Amyotrophic Lateral Sclerosis, The Primary Motor Neuron Disease, Jacob P. Naumann 2015 Cleveland State University

Amyotrophic Lateral Sclerosis, The Primary Motor Neuron Disease, Jacob P. Naumann

The Downtown Review

Amyotrophic lateral sclerosis is a degenerative neurological disease that damages nerve cells in the brain, in particular the neurons that are involved in voluntary muscle movements. Internationally the disorder is also known as Charcot’s disease and motor neuron disease. In the United States, amyotrophic lateral sclerosis is often referred to as Lou Gehrig’s disease, motor neuron disease, and more colloquially ALS. Amyotrophic Lateral Sclerosis is the most prominent of the five motor neuron diseases, distinguishing itself from the others through degeneration of both upper motor neurons (UMN) and lower motor neurons (LMN) respectively. The “Father of neurology” Jean-Marie ...


Novel Advances In Alzheimer's Disease, Jacob P. Naumann 2015 Cleveland State University

Novel Advances In Alzheimer's Disease, Jacob P. Naumann

The Downtown Review

Alzheimer’s disease, the most common form of dementia in adults, is a progressive degenerative neurological disease that affects memory, cognition, and behavior. Dr. Alois Alzheimer discovered and diagnosed the irreversible disease in 1906 after documenting the famous case of Auguste Deter.1 Since the discovery of the disease, numerous advances have made it possible to not only better understand the causal factors, but also to improve the medical diagnosis and preventative measures that healthcare providers can implement. For the first time since 1984, the National Institute on Aging (NIAA) and the Alzheimer’s Association (AA) proposed and published new ...


The Effects Of A Caloric Restrictive Diet On Bone Mineral Density And Bone Strength In Male And Female Rats, Haley Folta 2015 Chapman University

The Effects Of A Caloric Restrictive Diet On Bone Mineral Density And Bone Strength In Male And Female Rats, Haley Folta

Student Research Day Abstracts and Posters

The purpose of this study was to determine the existence of sex differences following a 40% caloric restrictive diet and its impact on tibial bone mineral density (BMD) and bone strength between male and female rats. Thirty-two, six-week old Sprague Dawley rats (16 males and 16 females) were randomly divided into an ad libitum fed control group (MC, n=8 and FC, n=8) and a pair fed diet group placed on the 40% caloric restriction (MD, n=8 and FD, n=8) for a 6 week period. The caloric restrictive diet was equivalent to the normal fed diet in ...


The Impact Of A 20% Vs. A 40% Caloric Restrictive Diet On Bone Mineral Density During The Growth Period In Male Rats, Kassandra Lee 2015 Chapman University

The Impact Of A 20% Vs. A 40% Caloric Restrictive Diet On Bone Mineral Density During The Growth Period In Male Rats, Kassandra Lee

Student Research Day Abstracts and Posters

Purpose: The purpose of this study was to determine the impact of a 20% and a 40% caloric restrictive diet on bone mineral density (BMD) and bone strength in male rats during the growth period. Methods: 32 male rats were randomly divided into: control groups (C20, n=8 and C40, n=8), a group fed the 20% caloric restrictive diet (D20, n=8), and a group fed the 40% caloric restrictive diet (D40, n=8). An animal in the caloric restrictive diet group was matched and pair fed with an animal in the control group for 6 weeks. Each caloric ...


Il-15 Induces Irisin Expression In Skeletal Muscle, James Krolopp, Shantae M. Thornton, Marcia J. Abbott 2015 Chapman University

Il-15 Induces Irisin Expression In Skeletal Muscle, James Krolopp, Shantae M. Thornton, Marcia J. Abbott

Student Research Day Abstracts and Posters

With the rising rate of obesity, brown adipose tissue(BAT) biology has become an area of interest. BAT is unique because it contains many mitochondria that require more energy than white adipose tissue. Increasing the amount of BAT can create a larger caloric need that can positively affect body composition. IL-15, a myokine, has been shown to activate mitochondrial activity resulting in decreases in fat mass and possibly increase BAT. The purpose of this study was to determine if IL-15 is involved in mediating genes positively associated with BAT. A skeletal muscle cell line was used in these studies and ...


The Anterolateral Ligament In 41 Paired Human Cadavers, Trevor Magnotti 2015 Bowling Green State University

The Anterolateral Ligament In 41 Paired Human Cadavers, Trevor Magnotti

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

No abstract provided.


The Physiological Effects Of A Cross Country Bike Ride On Novice Cyclists, Wade Weatherholt 2015 Western Kentucky University

The Physiological Effects Of A Cross Country Bike Ride On Novice Cyclists, Wade Weatherholt

Honors College Capstone Experience/Thesis Projects

Purpose: The physiological responses and adaptations experienced by novices engaging in cross-country cycling have received little attention in the scientific literature. Such endeavors typically involve a sizeable increase in physical activity for most individuals, but the acute and chronic effects of such an endurance feat are not well understood. Similarly, research shows that experienced cyclists often demonstrate osteoporosis in the spine, linked to many years of training accompanied by little or no weight bearing stress upon the axial skeleton. Greater understanding of these issues is needed, as long distance cycling has increased in popularity in recent years, and exercise professionals ...


Response Of Endothelial Cells To Quantified Hemodynamic Shear Stress, Hamed Avari 2015 The University of Western Ontario

Response Of Endothelial Cells To Quantified Hemodynamic Shear Stress, Hamed Avari

University of Western Ontario - Electronic Thesis and Dissertation Repository

Cardiovascular diseases (CVDs) are the number one cause of death globally. Arterial endothelial cell (EC) dysfunction plays a key role in many of these CVDs, such as atherosclerosis. Blood flow-induced wall shear stress (WSS), among many other pathophysiological factors, is shown to significantly contribute to EC dysfunction.

The present dissertation is an in vitro investigation of quantified WSS on ECs to quantitatively analyze the EC morphometric parameters, as well as cytoskeletal remodeling.

A hemodynamic facility based on the parallel plate flow chamber (PPFC) concept. The Laser Doppler Velocimetry (LDV) method with a custom set-up was implemented to suit the needs ...


Human: A Cat Dissection Tutorial, Sean P. Pierel 2015 University of Rhode Island

Human: A Cat Dissection Tutorial, Sean P. Pierel

Senior Honors Projects

HuMan: A Cat Dissection Tutorial

Human anatomy is a topic that many important scientific studies depend on, such as the study of medicine or the research of cultural gender identities and their respective anatomical characteristics. It is logical to expect those who want to work with and study the human body to have a greater understanding of what makes us what we are. Unfortunately this topic is typically considered difficult to learn as there is a very large amount of material to memorize and even more material to comprehend in order to truly achieve an understanding of the human body ...


Phenotypic Analysis Of Long Bones In Pannexin 3 Knockout Mice, Deidre Caskenette 2015 Western University

Phenotypic Analysis Of Long Bones In Pannexin 3 Knockout Mice, Deidre Caskenette

Masters of Clinical Anatomy Projects

Pannexin 3 (Panx3) is a channel forming glycoprotein that is highly expressed in skeletal tissues. Panx3 is induced at the growth plate of long bones where it regulates cell proliferation and differentiation, a key role in bone formation.

This study analyzes the phenotype of long bones in a novel Panx3 knockout (KO) mouse to assess the role of Panx3 in bone formation.

Ten KO and 10 wild-type (WT) adult mice were scanned using in vivo micro-CT. Right femora / humeri were digitized using homologous landmarks. Geometric morphometric analysis (multivariate statistical methods) allowed for quantitative comparison of shape, size and variation between ...


3d Visualization Of The Glomerulus Within Kidney Tissue Made Transparent Through Passive Optical Clearing, Tristan Conciatori 2015 Western University

3d Visualization Of The Glomerulus Within Kidney Tissue Made Transparent Through Passive Optical Clearing, Tristan Conciatori

Masters of Clinical Anatomy Projects

No abstract provided.


Adipose Tissue Therapeutics For Scar Rehabilitation After Thermal Injury, Dylan Perry, Jorge R. Lujan-Hernandez, Ava Chappell, So Yun Min, Raghu Appasani, Raziel Rojas-Rodriguez, Michael S. Chin, Silvia Corvera, Janice F. Lalikos 2015 University of Massachusetts Medical School

Adipose Tissue Therapeutics For Scar Rehabilitation After Thermal Injury, Dylan Perry, Jorge R. Lujan-Hernandez, Ava Chappell, So Yun Min, Raghu Appasani, Raziel Rojas-Rodriguez, Michael S. Chin, Silvia Corvera, Janice F. Lalikos

Senior Scholars Program

Background: Burn injuries are common and in the long term can lead to hypertrophic or keloid scars, pain and pruritus, limited mobility across joints, and disfigurement. Numerous reports suggest adipose derived tissues, including adipose derived stem cells (ADSCs) and processed lipoaspirate, can improve acutely healing wounds from a variety of etiologies including excisional, thermal, and radiation injuries by both secretion of growth factors and direct differentiation. There are many options for scar treatment, including laser therapy, silicone sheets, steroid injection, and even skin grafting however these techniques either lack optimal efficacy or involve significant cost and morbidity. Clinical case series ...


Acl Injuries In Female Athletes, Leslie A. Mesa 2015 Dominican University of California

Acl Injuries In Female Athletes, Leslie A. Mesa

Scholarly and Creative Works Conference

The Anterior Cruciate Ligament has been studied in many different ways and become injured more with the increase in sports participation by both male and female athletes. “ACL injuries are 9x more common in female athletes than male athletes and over 1.4 million women have been suffered from the ACL rupture which is twice the rate of the previous decade” (Hewett, 2010). ACL injuries are known to occur more in females than males because of differences in anatomy, knee alignment, muscle strength, and conditioning. Since female athletes are more prone to injury, it is important to incorporate neuromuscular training ...


Mcnamara 2014 Mmb1075 - Low Magnification Confocal Microscopy Of Tumor Angiogenesis, George McNamara 2015 M.D. Anderson Cancer Center

Mcnamara 2014 Mmb1075 - Low Magnification Confocal Microscopy Of Tumor Angiogenesis, George Mcnamara

George McNamara

McNamara 2014 MMB1075 - Low Magnification Confocal Microscopy of Tumor Angiogenesis

Book chapter from Paddock 2014 Confocal Microscopy

Book is online at http://www.springer.com/us/book/9781588293510


Non-Invasive Quantification Of Alveolar Morphometry Measurements In Older Never-Smokers, Gregory A. Paulin 2015 The University of Western Ontario

Non-Invasive Quantification Of Alveolar Morphometry Measurements In Older Never-Smokers, Gregory A. Paulin

University of Western Ontario - Electronic Thesis and Dissertation Repository

Diffusion-weighted noble gas pulmonary magnetic resonance imaging (MRI) provides in vivo images with a contrast uniquely sensitive to molecular displacement at cellular and sub-cellular length scales. We estimated the external airway radius (R) and internal airway radius (r) of the alveolar dimensions to evaluate potential differences in acinar duct morphometries in healthy older never-smokers and compared those with a group of ex-smokers. The acinar duct and alveolar MRI morphometry results were within the physiologically-valid range of parameters. Estimated values of internal (r) and external (R) airway radius as well as alveolar sheath (h) and mean linear intercept (Lm) for ...


Interstitial Cystitis: The Estrogen Connection, Heather G. Kuruvilla 2015 Cedarville University

Interstitial Cystitis: The Estrogen Connection, Heather G. Kuruvilla

The Research and Scholarship Symposium

Interstitial cystitis (IC), or painful bladder syndrome, is an autoimmune condition with an unknown etiology. Common symptoms include urinary urgency, frequency, and bladder and urethral pain and burning. This condition, like many autoimmune disorders, disproportionately affects females; therefore, female sex hormones are hypothesized to play a role in the disorder. My hypothesis is that estrogen, both endogenous and synthetic, affects the severity of IC symptoms. Through surveying the available literature on interstitial cystitis, I have found that IC symptoms often correlate with low estrogen. My hope is that by understanding more about how hormones affect IC, we can come up ...


Prostate Tumorigenesis Induced By Pten Deletion Involves Estrogen Receptor Beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, Arthur M. Mercurio 2015 University of Massachusetts Medical School

Prostate Tumorigenesis Induced By Pten Deletion Involves Estrogen Receptor Beta Repression, Paul Mak, Jianrong Li, Sanjoy Samanta, Cheng Chang, D. Joseph Jerry, Roger J. Davis, Irwin Leav, Arthur M. Mercurio

Molecular, Cell and Cancer Biology Publications

The role of ERbeta in prostate cancer is unclear, although loss of ERbeta is associated with aggressive disease. Given that mice deficient in ERbeta do not develop prostate cancer, we hypothesized that ERbeta loss occurs as a consequence of tumorigenesis caused by other oncogenic mechanisms and that its loss is necessary for tumorigenesis. In support of this hypothesis, we found that ERbeta is targeted for repression in prostate cancer caused by PTEN deletion and that loss of ERbeta is important for tumor formation. ERbeta transcription is repressed by BMI-1, which is induced by PTEN deletion and important for prostate tumorigenesis ...


Medical Students In Microscopic Anatomy And Pathology Laboratories: Design Of An E-Learning Histology And Histopathology Atlas As An Evolving Response To Interdisciplinary Pre-Clinical Curricular Needs, Michelle S. Davis, Alexandra Mills, Gisela Butera, Donald S. Karcher, Patricia S. Latham, Janette Krum, Rosalyn A. Jurjus 2015 George Washington University

Medical Students In Microscopic Anatomy And Pathology Laboratories: Design Of An E-Learning Histology And Histopathology Atlas As An Evolving Response To Interdisciplinary Pre-Clinical Curricular Needs, Michelle S. Davis, Alexandra Mills, Gisela Butera, Donald S. Karcher, Patricia S. Latham, Janette Krum, Rosalyn A. Jurjus

Anatomy and Regenerative Biology Faculty Publications

E-learning, also known as computer-assisted learning, successfully bridges anatomical knowledge and transferrable skills, such as critical analysis, teamwork, leadership and communication. Several institutions have already integrated histology and physiology in team based laboratory approaches, but integration of histology and pathology instruction has been done to a lesser extent. Our aim was to develop an e-learning atlas that integrates microanatomy and pathology laboratory for an interdisciplinary pre-clinical medical curriculum.

A multidisciplinary team of teaching faculty and students developed an online atlas (microanatomyatlas.com) that includes a library of histology and histopathology images. Traditional laboratory manual instructions and study objectives were added ...


Neuroanatomy Resources, Zachary Sharrow 2015 The College of Wooster

Neuroanatomy Resources, Zachary Sharrow

All Faculty Scholarship

This column will highlight several freely available online resources in neuroanatomy.The featured websites use images,video, animation, and more to create interactive aids for teaching and learning. Because neuroanatomy is a challenging component of all programs of study in medicine and in many allied fields,these resources will be useful for supplementation and self-study in a variety of settings.


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