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Unusual Case Of Pump Thrombosis In Lvad Patient With Covid-19 — Diagnostic Challenges, William H. Frick MD, Ryan D. Mallory, Maya Guglin, Eve Anderson, Erin N. Lushin, Rey P. Vivo, Kashif Saleem, Roopa A. Rao 2020 Indiana University

Unusual Case Of Pump Thrombosis In Lvad Patient With Covid-19 — Diagnostic Challenges, William H. Frick Md, Ryan D. Mallory, Maya Guglin, Eve Anderson, Erin N. Lushin, Rey P. Vivo, Kashif Saleem, Roopa A. Rao

The VAD Journal

We present the first reported case of left ventricular assist device (LVAD) pump thrombosis in the setting of the coronavirus pandemic. We describe the clinical features of the case which helped to differentiate coronavirus disease 19 (COVID-19) from LVAD pump thrombosis. The patient is 56-year-old female supported by destination LVAD therapy. She was originally implanted with a HeartMate II device in 2015 and underwent two pump exchanges in 2017 and 2019 for pump thrombosis, despite medication adherence. Shortly after routine lab work revealed near doubling of her lactate dehydrogenase (LDH) levels, she tested positive for COVID-19. She then developed power ...


An Analysis Of A New Shoe Technology In The Gait Patterns Of A Child With A Neurological Disability, Emma Madonna, Jeff Bauer 2020 The State University of New York College at Cortland

An Analysis Of A New Shoe Technology In The Gait Patterns Of A Child With A Neurological Disability, Emma Madonna, Jeff Bauer

The SUNY Journal of the Scholarship of Engagement: JoSE

This study focused on the application of a unique technology originally designed to supply biofeedback to dancers, but in this case was used to assist a child learning to walk while battling the effects of Cerebral Palsy. The musical shoes, called ElectroskipTM, utilize a biofeedback system that generates variable sounds/beats/songs when an individual is walking and placing pressure on their heel or toe. The study lasted six weeks with two sessions per week. Each session started with shoes fitted with ElectroskipTM technology placed on the child’s feet. When instructed by the researcher the child would ...


Cangrelor: Safe And Effective For Left Ventricular Assist Device Thrombosis, Roopa Rao, Eve Anderson, Mark Jones, Muhamed Safiia, Maya Guglin 2020 Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN

Cangrelor: Safe And Effective For Left Ventricular Assist Device Thrombosis, Roopa Rao, Eve Anderson, Mark Jones, Muhamed Safiia, Maya Guglin

The VAD Journal

Pump thrombosis is a devastating complication of left ventricular assist device implantation as it increases the risk of mortality and morbidity. Early and effective treatment is important to prevent the progression of the clot and to avoid the surgical need for pump exchange or heart transplant. The current strategies of intensifying anticoagulation therapy are not consistently effective and carry significant bleeding risks. Cangrelor is a new pharmacological agent that has been utilized as an antiplatelet agent in several cardiac procedures. In this case series, we describe the use of cangrelor for left ventricular assist device thrombosis in five patients. Cangrelor ...


A Differential Geometry-Based Machine Learning Algorithm For The Brain Age Problem, Justin Asher, Khoa Tan Dang, Maxwell Masters 2020 Purdue University Fort Wayne

A Differential Geometry-Based Machine Learning Algorithm For The Brain Age Problem, Justin Asher, Khoa Tan Dang, Maxwell Masters

The Journal of Purdue Undergraduate Research

No abstract provided.


Nano-Vesicle (Mis)Communication In Senescence-Related Pathologies, Sherin Saheera, Ajay Godwin Potnuri, Prasanna Krishnamurthy 2020 University of Massachusetts Medical School

Nano-Vesicle (Mis)Communication In Senescence-Related Pathologies, Sherin Saheera, Ajay Godwin Potnuri, Prasanna Krishnamurthy

COVID-19 Publications by UMMS Authors

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role ...


Implementing A Multi-Segment Foot Model In A Clinical Setting To Measure Inter-Segmental Joint Motions, Tahereh Amiri 2020 The University of Western Ontario

Implementing A Multi-Segment Foot Model In A Clinical Setting To Measure Inter-Segmental Joint Motions, Tahereh Amiri

Electronic Thesis and Dissertation Repository

It has been illustrated that measuring inter-segmental joint motions of the foot using a dynamic method is required to evaluate the function and level of impairment of the foot joints. Optical motion tracking using the multi-segment foot model (MSFM) developed by Jenkyn and Nicole (2007), has been demonstrated to be a valid tool for measuring the motion of the joints within the foot. However, in current practice, inter-segmental joint motions of this model are measured using a custom-written software (MATLAB) and it limits the clinical usefulness of this model. Hence, this study implemented the MSFM introduced by Jenkyn and Nicole ...


Upregulating Beta-Hexosaminidase Activity In Rodents Prevents Alpha-Synuclein Lipid Associations And Protects Dopaminergic Neurons From Alpha-Synuclein-Mediated Neurotoxicity, Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett 2020 Harvard Medical School

Upregulating Beta-Hexosaminidase Activity In Rodents Prevents Alpha-Synuclein Lipid Associations And Protects Dopaminergic Neurons From Alpha-Synuclein-Mediated Neurotoxicity, Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. Macbain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett

Open Access Articles

Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of beta-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson's disease (PD). alpha-synuclein (aSYN) inclusions, the diagnostic hallmark sign of PD, are frequently found in the brain in SD patients and HEX knockout mice, and HEX activity is reduced in the substantia nigra in PD. In this study, we biochemically demonstrate that HEX deficiency in mice causes formation of high-molecular weight (HMW) aSYN and ubiquitin in the brain. As expected from HEX enzymatic function requirements, overexpression in vivo of ...


Tibial Stress During Running Following A Repeated Calf‐Raise Protocol, Hannah M. Rice, Megan Kenny, Matthew A. Ellison, Jon Fulford, Stacey A. Meardon, Timothy R. Derrick, Joseph Hamill 2020 University of Exeter

Tibial Stress During Running Following A Repeated Calf‐Raise Protocol, Hannah M. Rice, Megan Kenny, Matthew A. Ellison, Jon Fulford, Stacey A. Meardon, Timothy R. Derrick, Joseph Hamill

Kinesiology Publications

Abstract Tibial stress fractures are a problematic injury amongst runners. Increased loading of the tibia has been observed following prolonged weight‐bearing activity and is suggested to be the result of reduced activity of the plantar flexor muscles. The musculature that spans the tibia contributes to bending of the bone and influences the magnitude of stress on the tibia during running. Participant‐specific models of the tibia can be used as a non‐invasive estimate of tibial stress. This study aimed to quantify tibial stress during running using participant‐specific bone geometry and to compare tibial stress before and after ...


Long Qt Syndrome Type 2: Emerging Strategies For Correcting Class 2 Kcnh2 (Herg) Mutations And Identifying New Patients, Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle 2020 University of Kentucky

Long Qt Syndrome Type 2: Emerging Strategies For Correcting Class 2 Kcnh2 (Herg) Mutations And Identifying New Patients, Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle

Physiology Faculty Publications

Significant advances in our understanding of the molecular mechanisms that cause congenital long QT syndrome (LQTS) have been made. A wide variety of experimental approaches, including heterologous expression of mutant ion channel proteins and the use of inducible pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from LQTS patients offer insights into etiology and new therapeutic strategies. This review briefly discusses the major molecular mechanisms underlying LQTS type 2 (LQT2), which is caused by loss-of-function (LOF) mutations in the KCNH2 gene (also known as the human ether-à-go-go-related gene or hERG). Almost half of suspected LQT2-causing mutations are missense mutations, and functional studies suggest ...


Single-Cell Rna Profiling Reveals Adipocyte To Macrophage Signaling Sufficient To Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Michael P. Czech 2020 University of Massachusetts Medical School

Single-Cell Rna Profiling Reveals Adipocyte To Macrophage Signaling Sufficient To Enhance Thermogenesis, Felipe Henriques, Alexander H. Bedard, Adilson L. Guilherme, Mark Kelly, Lawrence M. Lifshitz, Karl D. Bellve, Leslie A. Rowland, Batuhan Yenilmez, Shreya Kumar, Yetao Wang, Jeremy Luban, Michael P. Czech

Open Access Articles

Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate SNFs, and require adipocyte cyclic AMP/protein kinase A (cAMP/PKA) signaling for beige adipocyte appearance, as it is blocked by adipocyte Gsalpha deficiency. Surprisingly, however, in contrast to cold-exposed mice, neither iWAT denervation nor Nrg4 loss attenuated adipocyte browning in iAdFASNKO mice. Single-cell transcriptomic analysis of iWAT stromal cells revealed increased macrophages displaying gene expression ...


The History Of Early Modern Medicine In New Spain, El Primero Sueño, And Poet Sor Juana Inés De La Cruz, Daniel Hughes 2020 Hunter College of the City University of New York

The History Of Early Modern Medicine In New Spain, El Primero Sueño, And Poet Sor Juana Inés De La Cruz, Daniel Hughes

Grand Valley Journal of History

This essay analyzes poetry and other writing by Sor Juana Inés de la Cruz in the context of themes from Greco-Roman antiquity and the historical development of medicine in seventeenth century New Spain, now Mexico. Sor Juana’s El Primero Sueño, a Spanish language poetic silva, exhibits copious references to writers from classical antiquity, including Aristotle and Ovid. Establishing a context steeped in ideas from Greco-Roman antiquity, Sor Juana invokes the medical and philosophical legacy of foundational physician Galen of Pergamon. She also expands upon his ideas into the human anatomical realm, reflecting the increased early modern prominence of the ...


An Atlas Of Cell Types In The Mouse Epididymis And Vas Deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, Oliver J. Rando 2020 University of Massachusetts Medical School

An Atlas Of Cell Types In The Mouse Epididymis And Vas Deferens, Vera D. Rinaldi, Elisa Donnard, Kyle Gellatly, Morten Rasmussen, Alper Kucukural, Onur Yukselen, Manuel Garber, Upasna Sharma, Oliver J. Rando

University of Massachusetts Medical School Faculty Publications

Following testicular spermatogenesis, mammalian sperm continue to mature in a long epithelial tube known as the epididymis, which plays key roles in remodeling sperm protein, lipid, and RNA composition. To understand the roles for the epididymis in reproductive biology, we generated a single-cell atlas of the murine epididymis and vas deferens. We recovered key epithelial cell types including principal cells, clear cells, and basal cells, along with associated support cells that include fibroblasts, smooth muscle, macrophages and other immune cells. Moreover, our data illuminate extensive regional specialization of principal cell populations across the length of the epididymis. In addition to ...


Mycobacterium Tuberculosis Evasion Of Guanylate Binding Protein-Mediated Host Defense In Mice Requires The Esx1 Secretion System, Andrew J. Olive, Clare M. Smith, Christina E. Baer, Jörn Coers, Christopher M. Sassetti 2020 Michigan State University

Mycobacterium Tuberculosis Evasion Of Guanylate Binding Protein-Mediated Host Defense In Mice Requires The Esx1 Secretion System, Andrew J. Olive, Clare M. Smith, Christina E. Baer, Jörn Coers, Christopher M. Sassetti

University of Massachusetts Medical School Faculty Publications

Cell-intrinsic immune mechanisms control intracellular pathogens that infect eukaryotes. The intracellular pathogen Mycobacterium tuberculosis (Mtb) evolved to withstand cell-autonomous immunity to cause persistent infections and disease. A potent inducer of cell-autonomous immunity is the lymphocyte-derived cytokine IFNγ. While the production of IFNγ by T cells is essential to protect against Mtb, it is not capable of fully eradicating Mtb infection. This suggests that Mtb evades a subset of IFNγ-mediated antimicrobial responses, yet what mechanisms Mtb resists remains unclear. The IFNγ-inducible Guanylate binding proteins (GBPs) are key host defense proteins able to control infections with intracellular pathogens. GBPs were previously shown ...


Characterizing Recurrence Following Hybrid Ablation In Patients With Persistent Atrial Fibrillation, David C. Kress, Lynn Erickson, Tadele W. Mengesha, David Krum, Jasbir Sra 2020 Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke’s Medical Centers

Characterizing Recurrence Following Hybrid Ablation In Patients With Persistent Atrial Fibrillation, David C. Kress, Lynn Erickson, Tadele W. Mengesha, David Krum, Jasbir Sra

Journal of Patient-Centered Research and Reviews

Purpose: It is It is widely accepted that atrial fibrillation (AF) accounts for half of arrhythmia recurrences following endocardial catheter ablation of AF. An epicardial-endocardial approach (hybrid) has emerged as an alternative to endocardial ablation alone for the treatment of AF, yet recurrence after a hybrid procedure has not been well characterized. This retrospective study is aimed at characterizing recurrence following hybrid ablation for patients with persistent AF.

Methods: Patients with persistent AF (N = 108) received both endocardial and epicardial ablation of the posterior left atrial wall using catheter ablation and a small midline surgical approach (hybrid). Presence of atrial ...


Basement Membrane Damage By Ros- And Jnk-Mediated Mmp2 Activation Drives Macrophage Recruitment To Overgrown Tissue, Neha Diwanji, Andreas Bergmann 2020 University of Massachusetts Medical School

Basement Membrane Damage By Ros- And Jnk-Mediated Mmp2 Activation Drives Macrophage Recruitment To Overgrown Tissue, Neha Diwanji, Andreas Bergmann

Open Access Articles

Macrophages are a major immune cell type infiltrating tumors and promoting tumor growth and metastasis. To elucidate the mechanism of macrophage recruitment, we utilize an overgrowth tumor model ("undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages. Here we report that changes to the microenvironment of the overgrown tissue are important for recruiting macrophages. First, we describe a correlation between generation of reactive oxygen species (ROS) and damage of the basement membrane (BM) in all neoplastic, but not hyperplastic, models examined. ROS and the stress kinase JNK mediate the accumulation of matrix metalloproteinase 2 (Mmp2), damaging ...


Impact Of Parity On Gait Biomechanics, Bekah P. Stein 2020 University of Massachusetts Amherst

Impact Of Parity On Gait Biomechanics, Bekah P. Stein

Masters Theses

IMPACT OF PARITY ON GAIT BIOMCECHANICS

MAY 2020

BEKAH P. STEIN, B.A., UNIVERSITY OF MASSACHUSETTS AMHERST

M.A., UNIVERSITY OF MASSACHUSETTS AMHERST

Directed by: Professor Katherine A. Boyer

Background: Symptomatic knee osteoarthritis (OA) is an incurable condition that affects nearly 50% of adults, and women are twice as likely as men to develop OA. Throughout pregnancy, women experience large changes in morphology and gait mechanics, as well as changes in joint loading. It is possible these adaptations could cause lasting changes postpartum, which may potentially contribute to initiation of OA, thereby increasing the overall risk of OA for women ...


Anatomical Organization And Distinction Of The Sympathetic Inputs To Interscapular Brown Adipose Tissue And Inguinal White Adipose Tissue In The Mouse, Clara Jane Huesing 2020 Louisiana State University and Agricultural and Mechanical College

Anatomical Organization And Distinction Of The Sympathetic Inputs To Interscapular Brown Adipose Tissue And Inguinal White Adipose Tissue In The Mouse, Clara Jane Huesing

LSU Doctoral Dissertations

Adipose tissue is a dynamic endocrine organ that contains both the problem and the solution to discovering new therapies for individuals with obesity. Excessive adipose tissue disrupts energy balance and causes a host of comorbidities like insulin resistance and hypertension. On the other hand, adipose tissue is essential for life. During periods of energy demand, sympathetic nerve activity in brown and white adipose tissue stimulates thermogenesis and lipolysis; both of which decrease body weight and improve metabolic health. Therefore, comprehensive insight into the organization of sympathetic innervation and how it communicates with adipocytes is critical in order to utilize its ...


Regulation Of The Mammalian Swi/Snf Family Of Chromatin Remodeling Enzymes By Phosphorylation During Myogenesis, Teresita Padilla-Benavides, Pablo Reyes-Gutierrez, Anthony N. Imbalzano 2020 University of Massachusetts Medical School

Regulation Of The Mammalian Swi/Snf Family Of Chromatin Remodeling Enzymes By Phosphorylation During Myogenesis, Teresita Padilla-Benavides, Pablo Reyes-Gutierrez, Anthony N. Imbalzano

University of Massachusetts Medical School Faculty Publications

Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms that control chromatin remodeling, DNA methylation, histone modification, and activation of transcription factors. Chromatin remodeling enzymes utilize ATP hydrolysis to alter nucleosome structure and/or positioning. The mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) family of chromatin remodeling enzymes is essential for myogenesis. Here we review diverse and novel mechanisms of regulation of mSWI/SNF enzymes by kinases and phosphatases. The integration of classic signaling pathways with chromatin remodeling enzyme function impacts myoblast viability and proliferation as well ...


Current Insights In Cutaneous Lupus Erythematosus Immunopathogenesis, Colton J. Garelli, Maggi Ahmed Refat, Padma P. Nanaware, Zaida G. Ramirez-Ortiz, Medhi Rashighi, Jillian M. Richmond 2020 University of Massachusetts Medical School

Current Insights In Cutaneous Lupus Erythematosus Immunopathogenesis, Colton J. Garelli, Maggi Ahmed Refat, Padma P. Nanaware, Zaida G. Ramirez-Ortiz, Medhi Rashighi, Jillian M. Richmond

Open Access Articles

Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.


A Fatal Rectus Sheath Hematoma After A Myasthenia Crisis Case Report, Robert G. Michaud, Lesley B. Gordon 2020 Tufts University School of Medicine - Maine Track Program

A Fatal Rectus Sheath Hematoma After A Myasthenia Crisis Case Report, Robert G. Michaud, Lesley B. Gordon

Journal of Maine Medical Center

Introduction: Rectus sheath hematomas (RSH) generally occur due to damage to the inferior epigastric artery. They are rare causes of abdominal pain or acute blood loss anemia, but are an important diagnostic consideration because they can be cryptic and are potentially fatal.

Clinical Findings: An 85-year-old female who had been admitted to the hospital for 10 days with a myasthenia crisis was found to be abruptly hypotensive with a tender abdominal mass in the left lower quadrant subtly crossing midline. She was on prophylactic anticoagulation during her hospitalization.

Main diagnosis, therapeutics, interventions, and outcomes: The patient was initially stabilized with ...


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