Pathscan Enabler At Md Anderson Cancer Center, 2014 The University of Texas
Pathscan Enabler At Md Anderson Cancer Center, George Mcnamara
McNamara 20140703 - Additional Pathscan and Tiki_Goddess related resources
Our Pathscan Enabler IV, delivered July 2014, uses the QuickScan software to scan a histology slide in "two clicks" (after loading the
1. Push the QuickScan button on the front of the Pathscan Enabler.
2. Click the Scan button in the QuickScan pop-up application (optional: change scan area in the Prescan image window).
The image gets saved as a TIFF file to ...
Dreams And Learning, 2014 California Polytechnic State University
Dreams And Learning, Cody Mebane Gibbons
Project Summary: This study is being done to test one aspect of how paying attention to one’s dreams may influence our waking lives. The idea was inspired by research linking the brain processes involved in long-term memory storage to qualities of dreaming, as well as the potential for learning in lucid dreams. It is hypothesized that the more conscious one is of one’s dreams and dream world, the better one will be at learning. In order to test this, the dreaming ability of 300 Cal Poly students will be analyzed via dream questionnaires with the purpose of seeing ...
Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, 2014 California Polytechnic State University
Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael J. Lauth
Even though the senses of taste, smell, and sight are distinct, there is a significant overlap among them in our perceptions of objects that helps us understand and differentiate the world. Everyone has experienced, when his or her nose gets congested, that his or her sense of taste changes as well. Many individuals do not equally understand the top-down processing with taste when someone sees objects they are about to eat. In the replicated study by our principle investigator, a random convenience sample of young adults (n=162) were recruited and tested to determine if they could taste four Jelly ...
Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, 2014 Western Kentucky University
Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella
Masters Theses & Specialist Projects
HER2 overexpression in breast cancer tumors predicts lower overall survival. Because of the aggressive nature of HER2 tumors and the association with metastatic disease, the HER2 receptor holds great promise as a therapeutic target in metastatic breast cancer. We are developing small molecule inhibitors that bind to the ATP binding site of the tyrosine kinase domain in order to inhibit tyrosine auto-phosphorylation. This process controls biological pathways that mediate the cell growth. In normal cells this process is highly controlled. We are targeting the modification of the side chain of the hydroxy methyl group of 2-Hydroxy methyl-5,8-dimethoxy-1,4-naphthaquinone. These ...
A Biomimetic Multi-Layered Collagen-Based Scaffold For Osteochondral Repair., 2014 Royal College of Surgeons in Ireland
A Biomimetic Multi-Layered Collagen-Based Scaffold For Osteochondral Repair., Tanya J. Levingstone, Amos Matsiko, Glenn R Dickson, Fergal J. O'Brien, John P. Gleeson
Cartilage and osteochondral defects pose a significant challenge in orthopedics. Tissue engineering has shown promise as a potential method for the treatment of such defects; however, a long-lasting repair strategy has yet to be realized. This study focuses on the development of a layered construct for osteochondral repair, fabricated through a novel "iterative layering" freeze-drying technique. The process involved repeated steps of layer addition followed by freeze-drying, enabling control over material composition, pore size and substrate stiffness in each region of the construct, while also achieving a seamlessly integrated layer structure. The novel construct developed mimics the inherent gradient structure ...
Structural Alterations To The Axon Initial Segment Following Diffuse Axonal Injury As A Consequence Of Age, 2014 Virginia Commonwealth University
Structural Alterations To The Axon Initial Segment Following Diffuse Axonal Injury As A Consequence Of Age, William Behl
Theses and Dissertations
An epidemiological shift towards the elderly population has occurred in traumatic brain injury (TBI). Age is believed to be one of the strongest prognostic indicators following TBI. Diffuse axonal injury (DAI), a prevalent feature of TBI, is believed to be the primary cause for much of the morbidity and mortality associated with TBI. The pathobiology associated with DAI is believed to occur in response to the primary injury in a progressive, secondary fashion. Though the injury mechanisms behind DAI have been shown to occur at numerous sites along the axon, recent work suggests that the axon initial segment (AIS) may ...
The Osteogenic Potential Of The Marine-Derived Multi-Mineral Formula Aquamin Is Enhanced By The Presence Of Vitamin D., 2014 Royal College of Surgeons in Ireland
The Osteogenic Potential Of The Marine-Derived Multi-Mineral Formula Aquamin Is Enhanced By The Presence Of Vitamin D., Amro Widaa, Orlaith Brennan, D M. O'Gorman, Fergal J. O'Brien
Bone degenerative diseases are on the increase globally and are often problematic to treat. This has led to a demand to identify supplements that aid bone growth and formation. Aquamin is a natural multi-mineral food supplement, derived from the red algae Lithothamnion species which contains calcium, magnesium and 72 other trace minerals. It has been previously reported to increase bone formation and mineralisation. This study aimed to investigate the 28 day in vitro osteogenic response of Aquamin supplemented with Vitamin D. The osteogenic potential of MC3T3-E1 osteoblast-like cells was analysed in standard osteogenic medium supplemented with Aquamin +/- Vitamin D3, and ...
Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, 2014 University of Connecticut
Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino
Honors Scholar Theses
The following series of studies investigates the elimination and uptake trends of halothane, acetone, and ethanol vapors in the airways of C57BL/6J mice. These vapors were chosen because they span a wide range of solubilities, as indicated by their blood-air partition coefficients, and are not associated with any significant airway metabolism or reactivity with tissue substrates in vivo. Mice were exposed to a homogeneous vapor mixture containing a 1:1:1 ratio of halothane, acetone, and ethanol at relative concentrations of approximately 10 ppm. Exposure studies were performed with mice in two states, conscious and deceased, in order to ...
The Fenzian Unit: Applications To Physical Therapy And Beyond, 2014 Liberty University
The Fenzian Unit: Applications To Physical Therapy And Beyond, Jeshua Paul Spadino Mr.
Senior Honors Theses
The field of physical therapy includes many different treatment options in the form of exercises and modalities. The development of a low electrical stimulation signal through the Fenzian unit has provided a new outlook on healing. This device gives information to and receives information from the central nervous system (CNS) through electro-biofeedback and is separated into its own category of modalities. The device can be used to treat a wide range of ailments, all with no adverse effects. This makes it a promising tool in the medical field. It is currently being validated as an authentic medical device through clinical ...
Measured Expiratory Resistance Of The Blue And Green Acapella Devices As Setting Is Increased From 1–5; Amplitude 20, 30, 40, Amanda Wroblewski, Scott Hawkins
College of Health Sciences Presentations
Background: After reviewing the literature on both high flow and low flow Acapella devices, it was determined that most researchers evaluated only three frequency dial settings. Due to this gap, we chose to determine the expiratory resistance at each frequency dial setting for both high flow and low flow Acapella devices, as patient effort (amplitude) is increased on an electronic lung simulator. Hypothesis: 1) As the frequency dial setting is increased on the Acapella, the expiratory resistance will increase, and 2) as the patient effort (amplitude) is increased, the expiratory resistance will increase.
Methods: Each Acapella device was attached, separately ...
Brain Science And Stem Learning, 2014 University of Nebraska - Lincoln
Brain Science And Stem Learning, Dennis Molfese
DBER Speaker Series
Brain Science is an interdisciplinary science and as such touches on a host of domains that among others include Behavioral & Social Sciences, Biological Sciences, Computer & Information Science, Economics, Engineering (multiple domains from Electrical to Mechanical to Structural), Education, Human Resources, Engineering, Environmental, Education, Geosciences, Engineering, Mathematical, Physical Sciences, Psychology, and Zoology. The approach provides a means to study matter from an assortment of elements to the integration of complex domains that stretch from the interactions of neuropeptides to conscious thought that cover the lifespan of single cell organisms to humans. We will touch on a few of these dimensions, addressing ...
Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, 2014 Himmelfarb Health Sciences Library, The George Washington University
Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, Samantha Ahle, Jill Krapf, Kirsten Marie Brown, Juliet Lee, Gisela Butera, Ellen Goldman, Myriam Ferzli, Rosalyn A. Jurjus
GW Research Days 2014
Background: It is well documented in the medical education literature that students retain minimal anatomy knowledge when transitioning from pre-clinical didactics to clinical application on the wards. In a previous study at our own institution we were able to quantify this knowledge deficit in students on surgical clerkships, specifically surgery and obstetrics and gynecology (OB/GYN). Using our previous data, we designed an integrated, nested clinical teaching model utilizing e-modules to review clinically relevant surgical anatomy during their clinical rotations.
Objective: The goal of this study is to evaluate the impact of a newly designed method of teaching clinically relevant ...
Mechanisms Associated With The Regulation Of Vascular Structure And Function In Humans, 2014 McMaster University
Mechanisms Associated With The Regulation Of Vascular Structure And Function In Humans, Lisa Cotie
Open Access Dissertations and Theses
A comprehensive understanding of the mechanisms regulating vascular structure and function may assist in designing effective strategies to decrease cardiovascular disease risk. The current studies were designed to investigate a) relationships between collagen markers and arterial stiffness and markers of vasoconstriction and inflammation and endothelial function in humans with a wide range of vascular health, including overweight women, elderly healthy men, individuals with coronary artery disease, individuals with spinal cord injury and young healthy men and b) changes in arterial structure and function and circulating serum markers of type I collagen synthesis and degradation, vasoconstriction and inflammation in overweight pre-menopausal ...
Brain Blast 2014 Poster, 2014 University of New England
Brain Blast 2014 Poster, Annie Leslie
Announcement poster for UNE's Brain Blast 2014, a pechakucha-style brain health and safety awareness and learning event.
Brain Blast 2014 Speakers Poster, 2014 University of New England
Brain Blast 2014 Speakers Poster, Annie Leslie
Poster from UNE's Brain Blast 2014 listing the presenters at this event.
A Central Role For Vimentin In Regulating Repair Function During Healing Of The Lens Epithelium, 2014 Himmelfarb Health Sciences Library, The George Washington University
A Central Role For Vimentin In Regulating Repair Function During Healing Of The Lens Epithelium, A. S. Menko, B. M. Bleaken, A. A. Libowitz, L. Zhang, Mary Ann Stepp, J. L. Walker
Anatomy and Regenerative Biology Faculty Publications
Mock cataract surgery provides a unique ex vivo model for studying wound repair in a clinically relevant setting. Here wound healing involves a classical collective migration of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation of vimentin-rich repair cells. We report that vimentin is essential to the function of repair cells as the directors of the wound-healing process. Vimentin and not actin filaments are the predominant cytoskeletal elements in the lamellipodial extensions of the repair cells at the wound edge. These vimentin filaments link to paxillin-containing focal adhesions at the lamellipodial tips. Microtubules are involved ...
Skin Disease And Non-Syndromic Hearing Loss-Linked Cx30 Mutations Exhibit Several Distinct Cellular Pathologies, Amy Berger, John Kelly, Patrick Lajoie, Qing Shao, Dale Laird
Anatomy and Cell Biology Publications
Connexin 30 (Cx30), a member of the large gap junction protein family, plays a role in the homeostasis of the epidermis and inner ear through gap junctional intercellular communication (GJIC). Here, we investigated the underlying mechanisms of four autosomal dominant Cx30 gene mutations linked to hearing loss and/or various skin diseases. First, the T5M mutant linked to non-syndromic hearing loss formed functional gap junction channels and hemichannels, similar to wild type Cx30. The loss-of-function V37E mutant associated with Clouston syndrome or keratitis-ichthyosis-deafness syndrome was retained in the endoplasmic reticulum and significantly induced apoptosis. The G59R mutant linked to Vohwinkel ...
Implementation Of Do Not Attempt Resuscitate Orders In A Japanese Nursing Home, 2014 Boise State University
Implementation Of Do Not Attempt Resuscitate Orders In A Japanese Nursing Home, Nobuhiro Asai, Yoshihiro Ohkuni, Lonny Ashworth, Norihiro Kaneko
Respiratory Therapy Faculty Publications and Presentations
Objective: To investigate whether do not attempt resuscitation (DNAR) orders can be implemented in a standard nursing home in Japan, where routine DNAR orders are not yet common in many facilities including hospitals.
Method: Ninety-eight residents in a 100-bed nursing home were evaluated. All of the eligible residents and/or their family members were asked whether they wanted to receive resuscitation, including mechanical ventilation.
Result: The residents were 54 to 101 years of age (mean 83.3), with 27 males and 71 females. After administering the questionnaire, 92 (94%) patients did not want resuscitation and mechanical ventilation.
Conclusion: In a ...
Dysphagia And Disrupted Cranial Nerve Development In A Mouse Model Of Digeorge/22q11 Deletion Syndrome, 2014 Himmelfarb Health Sciences Library, The George Washington University
Dysphagia And Disrupted Cranial Nerve Development In A Mouse Model Of Digeorge/22q11 Deletion Syndrome, Beverly A. Karpinski, Thomas M. Maynard, Matthew S. Fralish, Samar Nuwayhid, Irene Zohn, Sally Ann Moody, Anthony-Samuel Lamantia
Anatomy and Regenerative Biology Faculty Publications
We assessed feeding-related developmental anomalies in the LgDel mouse model of Chromosome 22q11 Deletion Syndrome (22q11DS), a common developmental disorder that frequently includes perinatal dysphagia - debilitating feeding, swallowing and nutrition difficulties from birth onward - within its phenotypic spectrum. LgDel pups gain significantly less weight during the first postnatal weeks, and have several signs of respiratory infections due to food aspiration. Most 22q11 genes are expressed in anlagen of craniofacial and brainstem regions critical for feeding and swallowing, and diminished expression in LgDel embryos apparently compromises development of these regions. Palate and jaw anomalies indicate divergent oro-facial morphogenesis. Altered expression and ...
Extracting Vessel Structure From 3d Image Data, 2014 Western University
Extracting Vessel Structure From 3d Image Data, Yuchen Zhong
University of Western Ontario - Electronic Thesis and Dissertation Repository
This thesis is focused on extracting the structure of vessels from 3D cardiac images. In many biomedical applications it is important to segment the vessels preserving their anatomically-correct topological structure. That is, the final result should form a tree. There are many technical challenges when solving this image analysis problem: noise, outliers, partial volume. In particular, standard segmentation methods are known to have problems with extracting thin structures and with enforcing topological constraints. All these issues explain why vessel segmentation remains an unsolved problem despite years of research.
Our new efforts combine recent advances in optimization-based methods for image analysis ...