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Targeting Il13ralpha2 Activates Stat6-Tp63 Pathway To Suppress Breast Cancer Lung Metastasis, Panagiotis Papageorgis, Sait Ozturk, Arthur W. Lambert, Christiana M. Neophytou, Alexandros Tzatsos, Chen K. Wong, Sam Thiagalingam, Andreas I. Constantinou 2015 George Washington University

Targeting Il13ralpha2 Activates Stat6-Tp63 Pathway To Suppress Breast Cancer Lung Metastasis, Panagiotis Papageorgis, Sait Ozturk, Arthur W. Lambert, Christiana M. Neophytou, Alexandros Tzatsos, Chen K. Wong, Sam Thiagalingam, Andreas I. Constantinou

Anatomy and Regenerative Biology Faculty Publications

Introduction

Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to restrain its metastatic potential is urgently needed. In this study, we aimed to identify novel genes that drive metastasis of BLBC and to elucidate the underlying mechanisms of action.

Methods

An unbiased approach using gene expression profiling of a BLBC progression model and in silicoleveraging of pre-existing tumor transcriptomes were used to uncover metastasis-promoting genes. Lentiviral-mediated knockdown of interleukin-13 receptor alpha 2 (IL13Ralpha2) coupled with whole-body in vivo bioluminescence imaging was ...


Klf4-Sqstm1/P62-Associated Prosurvival Autophagy Contributes To Carfilzomib Resistance In Multiple Myeloma Models., Irene Riz, Teresa S. Hawley, Robert G. Hawley 2015 George Washington University

Klf4-Sqstm1/P62-Associated Prosurvival Autophagy Contributes To Carfilzomib Resistance In Multiple Myeloma Models., Irene Riz, Teresa S. Hawley, Robert G. Hawley

Anatomy and Regenerative Biology Faculty Publications

Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. Because of a high rate of immunoglobulin synthesis, the endoplasmic reticulum of MM cells is subjected to elevated basal levels of stress. Consequently, proteasome inhibitors, which exacerbate this stress by inhibiting ubiquitin-proteasome-mediated protein degradation, are an important new class of chemotherapeutic agents being used to combat this disease. However, MM cells still develop resistance to proteasome inhibitors such as carfilzomib. Toward this end, we have established carfilzomib-resistant derivatives of MM cell lines. We found that resistance to carfilzomib was associated with elevated levels of prosurvival autophagy, and Kruppel-like factor 4 ...


Amyotrophic Lateral Sclerosis, The Primary Motor Neuron Disease, Jacob P. Naumann 2015 Cleveland State University

Amyotrophic Lateral Sclerosis, The Primary Motor Neuron Disease, Jacob P. Naumann

The Downtown Review

Amyotrophic lateral sclerosis is a degenerative neurological disease that damages nerve cells in the brain, in particular the neurons that are involved in voluntary muscle movements. Internationally the disorder is also known as Charcot’s disease and motor neuron disease. In the United States, amyotrophic lateral sclerosis is often referred to as Lou Gehrig’s disease, motor neuron disease, and more colloquially ALS. Amyotrophic Lateral Sclerosis is the most prominent of the five motor neuron diseases, distinguishing itself from the others through degeneration of both upper motor neurons (UMN) and lower motor neurons (LMN) respectively. The “Father of neurology” Jean-Marie ...


Novel Advances In Alzheimer's Disease, Jacob P. Naumann 2015 Cleveland State University

Novel Advances In Alzheimer's Disease, Jacob P. Naumann

The Downtown Review

Alzheimer’s disease, the most common form of dementia in adults, is a progressive degenerative neurological disease that affects memory, cognition, and behavior. Dr. Alois Alzheimer discovered and diagnosed the irreversible disease in 1906 after documenting the famous case of Auguste Deter.1 Since the discovery of the disease, numerous advances have made it possible to not only better understand the causal factors, but also to improve the medical diagnosis and preventative measures that healthcare providers can implement. For the first time since 1984, the National Institute on Aging (NIAA) and the Alzheimer’s Association (AA) proposed and published new ...


The Effects Of A Caloric Restrictive Diet On Bone Mineral Density And Bone Strength In Male And Female Rats, Haley Folta 2015 Chapman University

The Effects Of A Caloric Restrictive Diet On Bone Mineral Density And Bone Strength In Male And Female Rats, Haley Folta

Student Research Day Abstracts and Posters

The purpose of this study was to determine the existence of sex differences following a 40% caloric restrictive diet and its impact on tibial bone mineral density (BMD) and bone strength between male and female rats. Thirty-two, six-week old Sprague Dawley rats (16 males and 16 females) were randomly divided into an ad libitum fed control group (MC, n=8 and FC, n=8) and a pair fed diet group placed on the 40% caloric restriction (MD, n=8 and FD, n=8) for a 6 week period. The caloric restrictive diet was equivalent to the normal fed diet in ...


The Impact Of A 20% Vs. A 40% Caloric Restrictive Diet On Bone Mineral Density During The Growth Period In Male Rats, Kassandra Lee 2015 Chapman University

The Impact Of A 20% Vs. A 40% Caloric Restrictive Diet On Bone Mineral Density During The Growth Period In Male Rats, Kassandra Lee

Student Research Day Abstracts and Posters

Purpose: The purpose of this study was to determine the impact of a 20% and a 40% caloric restrictive diet on bone mineral density (BMD) and bone strength in male rats during the growth period. Methods: 32 male rats were randomly divided into: control groups (C20, n=8 and C40, n=8), a group fed the 20% caloric restrictive diet (D20, n=8), and a group fed the 40% caloric restrictive diet (D40, n=8). An animal in the caloric restrictive diet group was matched and pair fed with an animal in the control group for 6 weeks. Each caloric ...


Il-15 Induces Irisin Expression In Skeletal Muscle, James Krolopp, Shantae M. Thornton, Marcia J. Abbott 2015 Chapman University

Il-15 Induces Irisin Expression In Skeletal Muscle, James Krolopp, Shantae M. Thornton, Marcia J. Abbott

Student Research Day Abstracts and Posters

With the rising rate of obesity, brown adipose tissue(BAT) biology has become an area of interest. BAT is unique because it contains many mitochondria that require more energy than white adipose tissue. Increasing the amount of BAT can create a larger caloric need that can positively affect body composition. IL-15, a myokine, has been shown to activate mitochondrial activity resulting in decreases in fat mass and possibly increase BAT. The purpose of this study was to determine if IL-15 is involved in mediating genes positively associated with BAT. A skeletal muscle cell line was used in these studies and ...


The Anterolateral Ligament In 41 Paired Human Cadavers, Trevor Magnotti 2015 Bowling Green State University

The Anterolateral Ligament In 41 Paired Human Cadavers, Trevor Magnotti

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

No abstract provided.


The Physiological Effects Of A Cross Country Bike Ride On Novice Cyclists, Wade Weatherholt 2015 Western Kentucky University

The Physiological Effects Of A Cross Country Bike Ride On Novice Cyclists, Wade Weatherholt

Honors College Capstone Experience/Thesis Projects

Purpose: The physiological responses and adaptations experienced by novices engaging in cross-country cycling have received little attention in the scientific literature. Such endeavors typically involve a sizeable increase in physical activity for most individuals, but the acute and chronic effects of such an endurance feat are not well understood. Similarly, research shows that experienced cyclists often demonstrate osteoporosis in the spine, linked to many years of training accompanied by little or no weight bearing stress upon the axial skeleton. Greater understanding of these issues is needed, as long distance cycling has increased in popularity in recent years, and exercise professionals ...


Response Of Endothelial Cells To Quantified Hemodynamic Shear Stress, Hamed Avari 2015 The University of Western Ontario

Response Of Endothelial Cells To Quantified Hemodynamic Shear Stress, Hamed Avari

University of Western Ontario - Electronic Thesis and Dissertation Repository

Cardiovascular diseases (CVDs) are the number one cause of death globally. Arterial endothelial cell (EC) dysfunction plays a key role in many of these CVDs, such as atherosclerosis. Blood flow-induced wall shear stress (WSS), among many other pathophysiological factors, is shown to significantly contribute to EC dysfunction.

The present dissertation is an in vitro investigation of quantified WSS on ECs to quantitatively analyze the EC morphometric parameters, as well as cytoskeletal remodeling.

A hemodynamic facility based on the parallel plate flow chamber (PPFC) concept. The Laser Doppler Velocimetry (LDV) method with a custom set-up was implemented to suit the needs ...


Human: A Cat Dissection Tutorial, Sean P. Pierel 2015 University of Rhode Island

Human: A Cat Dissection Tutorial, Sean P. Pierel

Senior Honors Projects

HuMan: A Cat Dissection Tutorial

Human anatomy is a topic that many important scientific studies depend on, such as the study of medicine or the research of cultural gender identities and their respective anatomical characteristics. It is logical to expect those who want to work with and study the human body to have a greater understanding of what makes us what we are. Unfortunately this topic is typically considered difficult to learn as there is a very large amount of material to memorize and even more material to comprehend in order to truly achieve an understanding of the human body ...


A Comparison Of The Scapular Flip Test Between Women With Breast Cancer And Healthy Controls, Mary Insana Fisher, Lucinda Pfalzer, Ellen W. Levy, Shana Harrington, Lynn H. Gerber, Nicole L. Stout 2015 University of Dayton

A Comparison Of The Scapular Flip Test Between Women With Breast Cancer And Healthy Controls, Mary Insana Fisher, Lucinda Pfalzer, Ellen W. Levy, Shana Harrington, Lynn H. Gerber, Nicole L. Stout

Physical Therapy Faculty Publications

Presentation at the World Confederation for Physical Therapy Congress, held May 1-4, 2015, in Singapore.

Background: The Scapular Flip test was designed to screen for spinal accessory nerve palsy. The spinal accessory nerve can be damaged in breast cancer surgery and treatment, resulting in scapular dyskinesis and upper limb (UL) impairment in women with breast cancer (BC). This test could be useful to screen for UL impairment in BC.

Purpose: The purpose of this study was to describe shoulder impairments as defined by a positive Flip Test in a group of women with BC at baseline, 1-3 months, and 12 ...


A Comparison Of The Upper Limb Lift Test Between Women With Breast Cancer And Healthy Control Subjects, Mary Insana Fisher, Lucinda Pfalzer, Ellen W. Levy, Shana Harrington, Lynn H. Gerber, Nicole L. Stout 2015 University of Dayton

A Comparison Of The Upper Limb Lift Test Between Women With Breast Cancer And Healthy Control Subjects, Mary Insana Fisher, Lucinda Pfalzer, Ellen W. Levy, Shana Harrington, Lynn H. Gerber, Nicole L. Stout

Physical Therapy Faculty Publications

Presentation at the World Confederation for Physical Therapy Congress, held May 1-4, 2015, in Singapore.

Background: Objective measures of upper limb (UL) function specific to breast cancer survivors (BC) are limited. Motion, strength, and muscular endurance are measurable components of UL function. A clinical test that quantifies these components is needed.

Purpose: This study compares the Upper Limb Lift Test (ULLT) between women with BC and healthy control subjects (HC) at baseline, 1-3 months, and 12+ months post-operatively enrolled in a prospective surveillance trial with early intervention. A secondary purpose was to validate the ULLT by comparing findings to self-reported ...


Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr. 2015 University of Connecticut - Storrs

Pathological Effects Of Repeated Concussive Tbi In Mouse Models: Periventricular Damage And Ventriculomegaly, Richard H. Wolferz Jr.

Honors Scholar Theses

Repeated concussive traumatic brain injury (rcTBI) is the most prominent form of head injury affecting the brain, with an estimated 1.7 million Americans affected each year (Kuhn 2012). Neurologists have been concerned about the danger of repeated head impacts since the 1920’s, but researchers have only begun to understand the long-term effects of rcTBI (McKee 2009). Although symptoms can be as mild as dizziness, current research suggests that multiple concussions can lead to a progressive degenerative brain disease known as chronic traumatic encephalopathy (CTE) (Luo 2008, McKee 2009, Kane 2013). Research on the brain is just beginning to ...


The Development Of Skeletal Muscle In Young Horses: An Ultrasonography And Satellite Cell Approach, Emma K. LaVigne 2015 University of Connecticut - Storrs

The Development Of Skeletal Muscle In Young Horses: An Ultrasonography And Satellite Cell Approach, Emma K. Lavigne

Honors Scholar Theses

Muscle growth in young horses is characterized by an increase in muscle cross-sectional area, which can be accomplished through the activation and differentiation of satellite cells. Satellite cells can be stimulated or inhibited in response to different cytokines and growth factors and are key mediators of muscle hypertrophy and regeneration. The aim of this study was to investigate the growth of the longissimus dorsi (LD) muscle in horses under 5 years of age and to obtain preliminary data on satellite cell behavior in foals. The area, width, height, and subcutaneous fat were measured using ultrasonography at 6-month increments over the ...


Anatomical Variation Of The Inferior Mesenteric Vein’S Drainage Pattern, Mina Zilaie B.S. 2015 University of North Texas Health Science Center at Fort Worth

Anatomical Variation Of The Inferior Mesenteric Vein’S Drainage Pattern, Mina Zilaie B.S.

Theses and Dissertations

The purpose of this project is to report the variable drainage pattern of the inferior mesenteric vein (IMV) as reported by medical students’ observations recorded on anatomical variation data sheets (n = 192). A meta-analysis on the drainage pattern of the inferior mesenteric vein as described in various anatomy resources was conducted (n = 40). The inferior mesenteric vein was observed to drain into the splenic vein, the superior mesenteric vein, and the junction between the superior mesenteric vein and the splenic vein. Anatomy resources do not commonly report all three drainage sites. It is imperative that all these common drainage sites ...


Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector Of Lymphatic Dysfunction, Germaine D. Agollah 2015 The University of Texas Graduate School of Biomedical Sciences at Houston

Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector Of Lymphatic Dysfunction, Germaine D. Agollah

UT GSBS Dissertations and Theses (Open Access)

The lymphatic system is essential for the transport of excess fluid, protein, and foreign materials from interstitial tissues to lymph nodes; for immune surveillance, and to maintain fluid homeostasis. Dysregulated lymphatics can be attributed to pathological conditions including tumor metastasis, inflammation, chronic wounds, obesity, blood vascular disorders, and lymphedema. Of these, lymphedema is the most extreme of lymphatic disorders and is represented by a spectrum of symptoms ranging from mild, subtle presentation to severe, disfiguring, overt presentation. Lymphedema is more manageable in the early stages of disease but severely reduces quality of life with progression. Due to lack of molecular ...


Muscle Unloading Induced Sex Specific Neurophysiological And Myofiber Profile Adaptations, Colleen Leathrum 2015 College of William and Mary

Muscle Unloading Induced Sex Specific Neurophysiological And Myofiber Profile Adaptations, Colleen Leathrum

Honors Theses

Muscle unloading affects a muscle’s ability to produce a contractile force and it affects the muscle’s endurance. The objective of this project was to investigate the differences between males and females and their neurophysiological adaptations to hindlimb suspension, an effective model of muscle unloading. Thirty nine young adult Wistar rats were divided into the following four groups: 1) male control, 2) female control, 3) male unloading, 4) female unloading. The unloading groups were subjected to a hindlimb suspension model. Soleus muscles were surgically removed to quantify neuromuscular function, and fluorescent fiber type staining was performed to quantify the ...


Visceral Space: Dissection And Michelangelo's Architecture, Chloe Costello 2015 University of Arkansas, Fayetteville

Visceral Space: Dissection And Michelangelo's Architecture, Chloe Costello

Architecture Undergraduate Honors Theses

This thesis focuses on the architectural work of Renaissance master Michelangelo Buonarroti, who, perhaps, is better known for his painting and sculpture than for his architecture. Nevertheless, his buildings are revered by architectural historians, such as James Ackerman, for their mimicry of bodily motion and emotion. Under the influence of Renaissance humanism, it was not uncommon for architects to validate their designs by reference to the human body, for example, basing the dimensions of a basilica on ideal bodily proportions. But, Michelangelo’s approach in his earliest architectural designs, such as the Medici Chapel (1521-1524) and the Laurentian Library (1523-1525 ...


Phenotypic Analysis Of Long Bones In Pannexin 3 Knockout Mice, Deidre Caskenette 2015 Western University

Phenotypic Analysis Of Long Bones In Pannexin 3 Knockout Mice, Deidre Caskenette

Masters of Clinical Anatomy Projects

Pannexin 3 (Panx3) is a channel forming glycoprotein that is highly expressed in skeletal tissues. Panx3 is induced at the growth plate of long bones where it regulates cell proliferation and differentiation, a key role in bone formation.

This study analyzes the phenotype of long bones in a novel Panx3 knockout (KO) mouse to assess the role of Panx3 in bone formation.

Ten KO and 10 wild-type (WT) adult mice were scanned using in vivo micro-CT. Right femora / humeri were digitized using homologous landmarks. Geometric morphometric analysis (multivariate statistical methods) allowed for quantitative comparison of shape, size and variation between ...


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