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Vascular Architecture Of The Liver In Shr And Wky Rats, Charalette Mathwig, Kenneth Willaert 2014 Minnesota State University, Mankato

Vascular Architecture Of The Liver In Shr And Wky Rats, Charalette Mathwig, Kenneth Willaert

Journal of Undergraduate Research at Minnesota State University, Mankato

The liver is a highly complex vascular organ containing an intricate network of arteries, arterioles, portal veins, veins, venules, and capillaries. This complex network could change in situations related to vascular disease such as hypertension. We examined the vasculature in rat livers by scanning electron microscopy. The tissue was prepared by perfusing either Mercox resin or polyurethane resin into the vasculature. Once the resin polymerized, each liver was placed in concentrated potassium hydroxide to corrode the tissue from the vascular casts. The casts were critical point dried, sputter coated with gold-palladium, and viewed by scanning electron microscopy. Examination of the ...


Simultaneous Measurement Of Smoothened Entry Into And Exit From The Primary Cilium, Jynho Kim, Elaine Y.C. Hsia, James Kim, Navdar Sever, Philip A. Beachy, Xiaoyan Zheng 2014 Himmelfarb Health Sciences Library, The George Washington University

Simultaneous Measurement Of Smoothened Entry Into And Exit From The Primary Cilium, Jynho Kim, Elaine Y.C. Hsia, James Kim, Navdar Sever, Philip A. Beachy, Xiaoyan Zheng

Anatomy and Regenerative Biology Faculty Publications

Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking. Using a photoconvertible fluorescent protein tag, we establish an assay that allows a separate but simultaneous examination of ciliary entry and exit of the Hedgehog signaling protein Smoothened in individual cells. We show that KAAD-cyclopamine selectively blocks entry, whereas ciliobrevin interferes initially with exit and eventually with both entry and exit of ciliary Smoothened. Our study provides an approach to understanding regulation of ciliary entry vs. exit of Hedgehog signaling components as well ...


Pathscan Enabler At Md Anderson Cancer Center, George McNamara 2014 The University of Texas

Pathscan Enabler At Md Anderson Cancer Center, George Mcnamara

George McNamara

McNamara 20140703 - Additional Pathscan and Tiki_Goddess related resources

http://works.bepress.com/gmcnamara/52

http://home.earthlink.net/~tiki_goddess/

http://works.bepress.com/gmcnamara/1/

http://works.bepress.com/gmcnamara/11/

https://www.linkedin.com/in/georgemcnamara

Our Pathscan Enabler IV, delivered July 2014, uses the QuickScan software to scan a histology slide in "two clicks" (after loading the

slide):

1. Push the QuickScan button on the front of the Pathscan Enabler.

2. Click the Scan button in the QuickScan pop-up application (optional: change scan area in the Prescan image window).

The image gets saved as a TIFF file to ...


Dreams And Learning, Cody Mebane Gibbons 2014 California Polytechnic State University

Dreams And Learning, Cody Mebane Gibbons

Symposium

Project Summary: This study is being done to test one aspect of how paying attention to one’s dreams may influence our waking lives. The idea was inspired by research linking the brain processes involved in long-term memory storage to qualities of dreaming, as well as the potential for learning in lucid dreams. It is hypothesized that the more conscious one is of one’s dreams and dream world, the better one will be at learning. In order to test this, the dreaming ability of 300 Cal Poly students will be analyzed via dream questionnaires with the purpose of seeing ...


Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael J. Lauth 2014 California Polytechnic State University

Interaction Among Gustation, Olfaction, And Vision In Flavor Identification, Michael J. Lauth

Symposium

Even though the senses of taste, smell, and sight are distinct, there is a significant overlap among them in our perceptions of objects that helps us understand and differentiate the world. Everyone has experienced, when his or her nose gets congested, that his or her sense of taste changes as well. Many individuals do not equally understand the top-down processing with taste when someone sees objects they are about to eat. In the replicated study by our principle investigator, a random convenience sample of young adults (n=162) were recruited and tested to determine if they could taste four Jelly ...


A Comparison Of Angiography Versus Intravascular Ultrasound In The Treatment Of Peripheral Arterial Disease, Michael Pompliano 2014 University of South Carolina

A Comparison Of Angiography Versus Intravascular Ultrasound In The Treatment Of Peripheral Arterial Disease, Michael Pompliano

Senior Theses

Peripheral Arterial Disease is a growing epidemic throughout the United States. It is estimated that 8 to 12 million Americans currently suffer from PAD, a disease of the circulatory system that limits blood flow to your hands and feet. This limited blood flow is due to the narrowing of the arteries that supply blood throughout your body and can disrupt the balance of the nerves and tissues that make up your extremities. If left untreated, it can cause irreparable, life- threatening damage that may result in amputation of the diseased limb. Although the mechanism of PAD is known and well ...


"What Happens In Romania..." Comes Back To The United States And Becomes A Quilt, Ashley Ehlers, Kaitlyn Torres 2014 University of South Carolina

"What Happens In Romania..." Comes Back To The United States And Becomes A Quilt, Ashley Ehlers, Kaitlyn Torres

Senior Theses

Our senior thesis project is a quilt that chronicles our experiences on the Maymester trip to Romania through the Honors College, during which we were able to shadow surgeons in the Oncology Hospital and General Surgery III Hospital in Cluj-Napoca. In our quilt, we included some of the most common surgeries we saw while shadowing Romanian doctors: breast removal, gall bladder removal, appendix removal, removal of a section of the large intestine, and removal of the uterus. The final product of this quilt shows every level of the abdominal muscles and organs from the anterior skin to the kidneys.

To ...


Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella 2014 Western Kentucky University

Functionalization And Modification Of Naphthaquinone Analogs As Her2 Kinase Inhibitors, Divya Jyothi Lella

Masters Theses & Specialist Projects

HER2 overexpression in breast cancer tumors predicts lower overall survival. Because of the aggressive nature of HER2 tumors and the association with metastatic disease, the HER2 receptor holds great promise as a therapeutic target in metastatic breast cancer. We are developing small molecule inhibitors that bind to the ATP binding site of the tyrosine kinase domain in order to inhibit tyrosine auto-phosphorylation. This process controls biological pathways that mediate the cell growth. In normal cells this process is highly controlled. We are targeting the modification of the side chain of the hydroxy methyl group of 2-Hydroxy methyl-5,8-dimethoxy-1,4-naphthaquinone. These ...


A Biomimetic Multi-Layered Collagen-Based Scaffold For Osteochondral Repair., Tanya J. Levingstone, Amos Matsiko, Glenn R Dickson, Fergal J. O'Brien, John P. Gleeson 2014 Royal College of Surgeons in Ireland

A Biomimetic Multi-Layered Collagen-Based Scaffold For Osteochondral Repair., Tanya J. Levingstone, Amos Matsiko, Glenn R Dickson, Fergal J. O'Brien, John P. Gleeson

Anatomy Articles

Cartilage and osteochondral defects pose a significant challenge in orthopedics. Tissue engineering has shown promise as a potential method for the treatment of such defects; however, a long-lasting repair strategy has yet to be realized. This study focuses on the development of a layered construct for osteochondral repair, fabricated through a novel "iterative layering" freeze-drying technique. The process involved repeated steps of layer addition followed by freeze-drying, enabling control over material composition, pore size and substrate stiffness in each region of the construct, while also achieving a seamlessly integrated layer structure. The novel construct developed mimics the inherent gradient structure ...


Structural Alterations To The Axon Initial Segment Following Diffuse Axonal Injury As A Consequence Of Age, William Behl 2014 Virginia Commonwealth University

Structural Alterations To The Axon Initial Segment Following Diffuse Axonal Injury As A Consequence Of Age, William Behl

Theses and Dissertations

An epidemiological shift towards the elderly population has occurred in traumatic brain injury (TBI). Age is believed to be one of the strongest prognostic indicators following TBI. Diffuse axonal injury (DAI), a prevalent feature of TBI, is believed to be the primary cause for much of the morbidity and mortality associated with TBI. The pathobiology associated with DAI is believed to occur in response to the primary injury in a progressive, secondary fashion. Though the injury mechanisms behind DAI have been shown to occur at numerous sites along the axon, recent work suggests that the axon initial segment (AIS) may ...


The Osteogenic Potential Of The Marine-Derived Multi-Mineral Formula Aquamin Is Enhanced By The Presence Of Vitamin D., Amro Widaa, Orlaith Brennan, D M. O'Gorman, Fergal J. O'Brien 2014 Royal College of Surgeons in Ireland

The Osteogenic Potential Of The Marine-Derived Multi-Mineral Formula Aquamin Is Enhanced By The Presence Of Vitamin D., Amro Widaa, Orlaith Brennan, D M. O'Gorman, Fergal J. O'Brien

Anatomy Articles

Bone degenerative diseases are on the increase globally and are often problematic to treat. This has led to a demand to identify supplements that aid bone growth and formation. Aquamin is a natural multi-mineral food supplement, derived from the red algae Lithothamnion species which contains calcium, magnesium and 72 other trace minerals. It has been previously reported to increase bone formation and mineralisation. This study aimed to investigate the 28 day in vitro osteogenic response of Aquamin supplemented with Vitamin D. The osteogenic potential of MC3T3-E1 osteoblast-like cells was analysed in standard osteogenic medium supplemented with Aquamin +/- Vitamin D3, and ...


Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino 2014 University of Connecticut

Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino

Honors Scholar Theses

The following series of studies investigates the elimination and uptake trends of halothane, acetone, and ethanol vapors in the airways of C57BL/6J mice. These vapors were chosen because they span a wide range of solubilities, as indicated by their blood-air partition coefficients, and are not associated with any significant airway metabolism or reactivity with tissue substrates in vivo. Mice were exposed to a homogeneous vapor mixture containing a 1:1:1 ratio of halothane, acetone, and ethanol at relative concentrations of approximately 10 ppm. Exposure studies were performed with mice in two states, conscious and deceased, in order to ...


The Fenzian Unit: Applications To Physical Therapy And Beyond, Jeshua Paul Spadino Mr. 2014 Liberty University

The Fenzian Unit: Applications To Physical Therapy And Beyond, Jeshua Paul Spadino Mr.

Senior Honors Theses

The field of physical therapy includes many different treatment options in the form of exercises and modalities. The development of a low electrical stimulation signal through the Fenzian unit has provided a new outlook on healing. This device gives information to and receives information from the central nervous system (CNS) through electro-biofeedback and is separated into its own category of modalities. The device can be used to treat a wide range of ailments, all with no adverse effects. This makes it a promising tool in the medical field. It is currently being validated as an authentic medical device through clinical ...


Measured Expiratory Resistance Of The Blue And Green Acapella Devices As Setting Is Increased From 1–5; Amplitude 20, 30, 40, Amanda Wroblewski, Scott Hawkins 2014 Boise State University

Measured Expiratory Resistance Of The Blue And Green Acapella Devices As Setting Is Increased From 1–5; Amplitude 20, 30, 40, Amanda Wroblewski, Scott Hawkins

College of Health Sciences Presentations

Background: After reviewing the literature on both high flow and low flow Acapella devices, it was determined that most researchers evaluated only three frequency dial settings. Due to this gap, we chose to determine the expiratory resistance at each frequency dial setting for both high flow and low flow Acapella devices, as patient effort (amplitude) is increased on an electronic lung simulator. Hypothesis: 1) As the frequency dial setting is increased on the Acapella, the expiratory resistance will increase, and 2) as the patient effort (amplitude) is increased, the expiratory resistance will increase.

Methods: Each Acapella device was attached, separately ...


Brain Science And Stem Learning, Dennis Molfese 2014 University of Nebraska - Lincoln

Brain Science And Stem Learning, Dennis Molfese

DBER Speaker Series

Brain Science is an interdisciplinary science and as such touches on a host of domains that among others include Behavioral & Social Sciences, Biological Sciences, Computer & Information Science, Economics, Engineering (multiple domains from Electrical to Mechanical to Structural), Education, Human Resources, Engineering, Environmental, Education, Geosciences, Engineering, Mathematical, Physical Sciences, Psychology, and Zoology. The approach provides a means to study matter from an assortment of elements to the integration of complex domains that stretch from the interactions of neuropeptides to conscious thought that cover the lifespan of single cell organisms to humans. We will touch on a few of these dimensions, addressing ...


Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, Samantha Ahle, Jill Krapf, Kirsten Marie Brown, Juliet Lee, Gisela Butera, Ellen Goldman, Myriam Ferzli, Rosalyn A. Jurjus 2014 Himmelfarb Health Sciences Library, The George Washington University

Improving Anatomical Knowledge Retention In Medical Students Entering The Surgery And Obstetrics And Gynecology Clinical Rotations By Nesting Interactive Modules, Samantha Ahle, Jill Krapf, Kirsten Marie Brown, Juliet Lee, Gisela Butera, Ellen Goldman, Myriam Ferzli, Rosalyn A. Jurjus

GW Research Days 2014

Background: It is well documented in the medical education literature that students retain minimal anatomy knowledge when transitioning from pre-clinical didactics to clinical application on the wards. In a previous study at our own institution we were able to quantify this knowledge deficit in students on surgical clerkships, specifically surgery and obstetrics and gynecology (OB/GYN). Using our previous data, we designed an integrated, nested clinical teaching model utilizing e-modules to review clinically relevant surgical anatomy during their clinical rotations.

Objective: The goal of this study is to evaluate the impact of a newly designed method of teaching clinically relevant ...


Mechanisms Associated With The Regulation Of Vascular Structure And Function In Humans, Lisa Cotie 2014 McMaster University

Mechanisms Associated With The Regulation Of Vascular Structure And Function In Humans, Lisa Cotie

Open Access Dissertations and Theses

A comprehensive understanding of the mechanisms regulating vascular structure and function may assist in designing effective strategies to decrease cardiovascular disease risk. The current studies were designed to investigate a) relationships between collagen markers and arterial stiffness and markers of vasoconstriction and inflammation and endothelial function in humans with a wide range of vascular health, including overweight women, elderly healthy men, individuals with coronary artery disease, individuals with spinal cord injury and young healthy men and b) changes in arterial structure and function and circulating serum markers of type I collagen synthesis and degradation, vasoconstriction and inflammation in overweight pre-menopausal ...


Brain Blast 2014 Poster, Annie Leslie 2014 University of New England

Brain Blast 2014 Poster, Annie Leslie

Brain Blast

Announcement poster for UNE's Brain Blast 2014, a pechakucha-style brain health and safety awareness and learning event.


Brain Blast 2014 Speakers Poster, Annie Leslie 2014 University of New England

Brain Blast 2014 Speakers Poster, Annie Leslie

Brain Blast

Poster from UNE's Brain Blast 2014 listing the presenters at this event.


A Central Role For Vimentin In Regulating Repair Function During Healing Of The Lens Epithelium, A. S. Menko, B. M. Bleaken, A. A. Libowitz, L. Zhang, Mary Ann Stepp, J. L. Walker 2014 Himmelfarb Health Sciences Library, The George Washington University

A Central Role For Vimentin In Regulating Repair Function During Healing Of The Lens Epithelium, A. S. Menko, B. M. Bleaken, A. A. Libowitz, L. Zhang, Mary Ann Stepp, J. L. Walker

Anatomy and Regenerative Biology Faculty Publications

Mock cataract surgery provides a unique ex vivo model for studying wound repair in a clinically relevant setting. Here wound healing involves a classical collective migration of the lens epithelium, directed at the leading edge by an innate mesenchymal subpopulation of vimentin-rich repair cells. We report that vimentin is essential to the function of repair cells as the directors of the wound-healing process. Vimentin and not actin filaments are the predominant cytoskeletal elements in the lamellipodial extensions of the repair cells at the wound edge. These vimentin filaments link to paxillin-containing focal adhesions at the lamellipodial tips. Microtubules are involved ...


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