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Discovering A Gold Mine Of U.S. Government Information: Exploring The Hathitrust Catalog And Its Rich Veins, Bert Chapman 2014 Purdue University

Discovering A Gold Mine Of U.S. Government Information: Exploring The Hathitrust Catalog And Its Rich Veins, Bert Chapman

Libraries Faculty and Staff Presentations

The Hathitrust Catalog provides researchers at member institutions with exponentially expanded access to historical U.S. Government information resources. This presentation describes how researchers can use this resource to conduct substantive research using government information resources on public policy issues such as Internal Revenue Service program problems, infectious diseases such as Ebola, and U.S. foreign relations with the former Soviet Union/Russian Federation.


Increased Risk For Vitamin D Deficiency In Obese Children With Both Celiac Disease And Type 1 Diabetes, Nithya Setty-Shah, Louise S. Maranda, Benjamin U. Nwosu 2014 University of Massachusetts Medical School

Increased Risk For Vitamin D Deficiency In Obese Children With Both Celiac Disease And Type 1 Diabetes, Nithya Setty-Shah, Louise S. Maranda, Benjamin U. Nwosu

Endocrinology/Diabetes

Background. It is unknown whether the coexistence of type 1 diabetes (T1D) and celiac disease (CD) increases the risk for vitamin D deficiency.

Aims. To determine the vitamin D status and the risk for vitamin D deficiency in prepubertal children with both T1D and CD compared to controls, TID, and CD.

Subjects and Methods. Characteristics of 62 prepubertal children of age 2–13 y with either CD + T1D (𝑛 = 22, 9.9 ± 3.1 y), CD only (𝑛 = 18, 8.9 ± 3.3 y), or T1D only (𝑛 = 22, 10.1 ± 2.8 y) were compared to 49 controls of ...


Gut Bacteria And Their Influence On Metabolic Disorders, Stephanie Sorbara 2014 Sacred Heart University

Gut Bacteria And Their Influence On Metabolic Disorders, Stephanie Sorbara

Biology Undergraduate Publications

The human gut microbial genome encodes for several metabolic processes that are not encoded for in the human genome. Through the study of metagenomics, mice, and human models, researchers have shown that changes in the gut bacterial composition can generate oxidative stress, release endotoxins, and induce lipogenesis. These pathways can disrupt normal metabolic function, resulting in obesity and other related metabolic disorders such as diabetes. Most of the health implications associated with obesity originate from the biological reactions carried out by the gut bacteria, which are strongly impacted by environmental factors. Probiotics, prebiotics and fecal transplantation are methods that can ...


Can Mhealth Improve Risk Assessment In Underserved Populations? Acceptability Of A Breast Health Questionnaire App In Ethnically Diverse, Older, Low-Income Women., Carolina Bravo, Cristina O’Donoghue, Celia P. Kaplan, Judith Luce, Elissa Ozanne 2014 University of Nevada, Las Vegas

Can Mhealth Improve Risk Assessment In Underserved Populations? Acceptability Of A Breast Health Questionnaire App In Ethnically Diverse, Older, Low-Income Women., Carolina Bravo, Cristina O’Donoghue, Celia P. Kaplan, Judith Luce, Elissa Ozanne

Journal of Health Disparities Research and Practice

Background: Use of mobile health (mHealth) tools has expanded rapidly but little research has been done on its acceptability by low-income, diverse, older patient populations.

Objective: To assess the attitudes of a diverse group of underserved women on the acceptability and usability of mHealth tools in a clinical setting using a breast health questionnaire application (app) at a public hospital mammography clinic.

Methods: Semi-structured interviews were conducted in a breast-imaging center of an urban safety net institution from July-August 2012. Interviews included pre- and post-questions. Women completed the Athena breast health questionnaire app on an iPad and were asked about ...


The Impact Of Protocol Assignment For Older Adolescents With Hodgkin Lymphoma, Richard S. Pieters, Henry Wagner, Stephen P. Baker, Karen Morano, Kenneth Ulin, Maria Giulia Cicchetti, Maryann Bishop-Jodoin, Thomas J. Fitzgerald 2014 University of Massachusetts Medical School

The Impact Of Protocol Assignment For Older Adolescents With Hodgkin Lymphoma, Richard S. Pieters, Henry Wagner, Stephen P. Baker, Karen Morano, Kenneth Ulin, Maria Giulia Cicchetti, Maryann Bishop-Jodoin, Thomas J. Fitzgerald

Radiation Oncology Publications and Presentations

Background and Purpose: Hodgkin lymphoma (HL) treatment has evolved to reduce or avoid radiotherapy (RT) dose and volume and minimize the potential for late effects. Some older adolescents are treated on adult protocols. The purpose of this study is to examine the protocol assignment of older adolescents and its impact on radiation dose to relevant thoracic structures.

Materials and Methods: Cooperative group data were reviewed and 12 adolescents were randomly selected from a pediatric HL protocol. Treatment plans were generated per one pediatric and two adult protocols. Dose volume histograms for heart, lung, and breast allowed comparison of radiation dose ...


The President’S National Security Agenda Curtailing Ebola, Safeguarding The Future, Lawrence O. Gostin, Henry A. Waxman, William Foege 2014 Georgetown University Law Center

The President’S National Security Agenda Curtailing Ebola, Safeguarding The Future, Lawrence O. Gostin, Henry A. Waxman, William Foege

Georgetown Law Faculty Publications and Other Works

A clear lesson of the Ebola epidemic in West Africa is the need for strong public health systems globally, including in the United States. Ebola has highlighted the dangers of weak public health systems, from the immense shortage of health workers in West Africa to the budget cuts at the U.S. Centers for Disease Control and Prevention. In response to Ebola and the broader threat of infectious disease, President Obama has proposed a $6.2 billion supplemental funding request to Congress. The supplemental would surge resources for containing and treating Ebola in West Africa -- including a reserve of funds ...


I Know My Hiv Status, But Do You Know Yours?, Jillian L. Baker DrPH, Ed.M., Zupenda M. Davis DrPH, MPH, MCHES 2014 La Salle University

I Know My Hiv Status, But Do You Know Yours?, Jillian L. Baker Drph, Ed.M., Zupenda M. Davis Drph, Mph, Mches

Explorer Café

No abstract provided.


F1000research: Tics Welcomes You To 21st Century Biomedical Publishing [V1; Ref Status: Not Peer Reviewed, Http://F1000r.Es/4o1], Kevin J. Black 2014 Washington University School of Medicine

F1000research: Tics Welcomes You To 21st Century Biomedical Publishing [V1; Ref Status: Not Peer Reviewed, Http://F1000r.Es/4o1], Kevin J. Black

Kevin J. Black, MD

Tics are repeated, usually suppressible movements or vocalizations. They are the defining features of tic disorders including Tourette syndrome, but many people have them for shorter durations at some point in childhood. This editorial marks the beginning of the F1000Research: Tics specialty section, an effort to provide a single portal to modern research on tics and tic disorders. Publications in F1000Research: Tics benefit from F1000Research’s novel approach to publishing, in which articles can be published within days of submission. Peer review happens after publication and is fully open. When the submitted article or a revision is approved, it is ...


Nutrition And Cancer, Angela Beeler, Katherine Saunders, Alexis Penney, James Liebmann, Richard S. Pieters 2014 University of Massachusetts Medical School

Nutrition And Cancer, Angela Beeler, Katherine Saunders, Alexis Penney, James Liebmann, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents a summary of the nutritional concerns in oncology patients. Nutritional intake is frequently deficient in patients undergoing cancer treatment and should be assessed and treated. There are unique nutritional needs of the patient based on their site of cancer and effects of their particular treatment. There is little evidence that dietary manipulation or supplementation can produce a significant decrease in cancer risk.


Acceptability Of A Novel Smartphone Application For Rhythm Evaluation In Patients With Atrial Fibrillation, Daniel J. Amante, Thomas M. English, Jane S. Saczynski, Nada Esa, Iryna Nieto, Ki H. Chon, David D. McManus 2014 University of Massachusetts Medical School

Acceptability Of A Novel Smartphone Application For Rhythm Evaluation In Patients With Atrial Fibrillation, Daniel J. Amante, Thomas M. English, Jane S. Saczynski, Nada Esa, Iryna Nieto, Ki H. Chon, David D. Mcmanus

Community Engagement and Research Symposium

Background: Investigators at UMass Medical School and WPI co-developed a novel smartphone application (app), PULSESMART, that detects atrial fibrillation (AF). AF is the world’s most common, serious heart rhythm problem. In its early stages, most cases of AF are paroxysmal (pAF), making them difficult to identify early in the course of disease. Long-term cardiac monitoring is frequently needed to diagnose and prevent complications from AF, such as stroke. Home monitoring for AF can be clinically impactful but existing technologies have cost or methodological limitations. Data are needed on the potential acceptability and usability of heart rhythm monitoring applications.

Aim ...


Cancer Surveillance And Outreach In Carlisle, Massachusetts: An Analysis Of Mdph Cancer And Environmental Health Data In A Small Town Context, David Estabrook, Linda Fantasia, Catherine Galligan 2014 University of Massachusetts Medical School

Cancer Surveillance And Outreach In Carlisle, Massachusetts: An Analysis Of Mdph Cancer And Environmental Health Data In A Small Town Context, David Estabrook, Linda Fantasia, Catherine Galligan

Community Engagement and Research Symposium

Introduction: The Carlisle Board of Health (BOH) sought to understand how cancer affects its town (population under 5,000), using data on expected and observed cancer incidence provided by the Massachusetts Cancer Registry (MCR). This project examined cancer incidence data summarized by city/town in five-year intervals, evaluated demographic and environmental factors that could contribute to cancer, and provided recommendations for cancer outreach. Methods: MCR city/town reports from 1995-2009 were examined to identify community cancer trends. A literature review focused on cancers of concern to guide outreach efforts. Data on contributing environmental exposures and health behaviors were explored to ...


Discordant Documentation Of Obesity Body Mass Index And Obesity Diagnosis In Electronic Medical Records, Jennifer T. Fink, George L. Morris III, Maharaj Singh, David A. Nelson, Renee E. Walker, Ron A. Cisler 2014 Aurora Health Care

Discordant Documentation Of Obesity Body Mass Index And Obesity Diagnosis In Electronic Medical Records, Jennifer T. Fink, George L. Morris Iii, Maharaj Singh, David A. Nelson, Renee E. Walker, Ron A. Cisler

Journal of Patient-Centered Research and Reviews

Purpose: This study examined concordance between presence of obesity body mass index (BMI), defined as BMI ≥ 30, in the patient’s electronic medical record (EMR) and a documented diagnosis of obesity.

Methods: We conducted a retrospective review of the EMR in a large health care system for a 1-year period (2012). A total of 397,313 patients met the study criteria of having at least one physician visit, being at least 18 years of age, and not being pregnant. Of those, 158,327 (40%) had a recorded BMI ≥ 30. We examined the EMR of these obese patients to determine whether ...


Autoantibodies To The Ny-Eso-1 Tumor Antigen In Metastatic Melanoma: Sialylation Of The Fc Region Of Immunoglobulin G Induces Differential Expression Signatures Of Inflammatory Molecules During Dendritic Cell Differentiation And Maturation, Martin Oaks, Nathaniel Rein, John O. Richards, James Shaffer 2014 Aurora Health Care

Autoantibodies To The Ny-Eso-1 Tumor Antigen In Metastatic Melanoma: Sialylation Of The Fc Region Of Immunoglobulin G Induces Differential Expression Signatures Of Inflammatory Molecules During Dendritic Cell Differentiation And Maturation, Martin Oaks, Nathaniel Rein, John O. Richards, James Shaffer

Journal of Patient-Centered Research and Reviews

Purpose: We tested the hypothesis that different glycoforms of antibodies from patients with metastatic melanoma have different functional effects on human dendritic cell differentiation and maturation.

Methods: Antibodies to the cancer antigen NY-ESO-1 were affinity-purified from patients with melanoma and further fractionated into different glycoforms by lectin chromatography. Sialic acid-rich and sialic acid-poor fractions of these immunoglobulin G antibodies (IgG) were added to dendritic cell cultures during both differentiation and maturation, and the resulting cellular messenger RNA (mRNA) and culture supernatants were tested by microarray and enzyme-linked immunoassay for molecules related to inflammatory pathways.

Results: We identified unique mRNA and ...


Recurrent Aphthous Stomatitis: Diagnosis And Management In Primary Care, Jillian Hudson 2014 Aurora Health Care

Recurrent Aphthous Stomatitis: Diagnosis And Management In Primary Care, Jillian Hudson

Journal of Patient-Centered Research and Reviews

Recurrent aphthous stomatitis (canker sores) is a very common oral condition that remains incompletely understood. Presentation has been well-classified into minor, major or herpetiform subcategories based on clinical features, but exact etiology is unknown. Because etiology is unclear, treatments are primarily empiric and aimed at symptom reduction rather than prevention or cure. However, there are several methods, both topical and systemic, that can be easily and affordably utilized in the primary care setting.


Which Clinical Guidelines Should Be Implemented For Management Of Osteopenia In Primary Care? A Clin-Iq, Turia Hollingsworth 2014 Aurora Health Care

Which Clinical Guidelines Should Be Implemented For Management Of Osteopenia In Primary Care? A Clin-Iq, Turia Hollingsworth

Journal of Patient-Centered Research and Reviews

Literature review was conducted to determine clinical guidelines for osteopenia management of immunocompetent patients in the primary care setting. It was concluded that pharmacological treatment should be offered to patients with osteopenia if they are considered high risk, which can be determined by utilizing the World Health Organization Fracture Risk Assessment Tool (FRAX®) to evaluate 10-year risk. Patients with a calculated hip fracture probability of at least 3% or those with probability of 20% or more for all osteoporotic fractures may be offered bisphosphonate therapy.


What Is Pfapa And Why Does It Matter?, Dennis J. Baumgardner 2014 Aurora Health Care

What Is Pfapa And Why Does It Matter?, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

PFAPA, the syndrome of periodic fever, aphthous stomatitis, pharyngitis and cervical lymphadentitis, is an uncommon disease of episodic immune dysregulation that usually begins in early childhood. Symptoms occur at regular, predictable intervals, with healthy periods in between, and generally include the namesake signs and various other constitutional symptoms such as fever and fatigue. The etiology is unknown and there is no definitive diagnostic test or treatment. Uncertainty during the period of searching for a diagnosis may be disconcerting to the family and the clinician. Single-dose prednisone is effective for resolving the fever of PFAPA episodes within just a few hours ...


Septal Myectomy In Obstructive Hypertrophic Cardiomyopathy High Risk Patients, Heather Geist, Matthew W. Martinez MD, James K. Wu MD 2014 Lehigh Valley Health Network

Septal Myectomy In Obstructive Hypertrophic Cardiomyopathy High Risk Patients, Heather Geist, Matthew W. Martinez Md, James K. Wu Md

Department of Medicine

No abstract provided.


Improving Outcomes In Diabetic Patients, Daniel Tseytlin DO, Cheryl Bloomfield MD, Ranjit R. Nair MD, Carolyn Casey DO, Vlad Vlatsis DO, Maura Bucciarelli DO, Chris Kern DO, Stephen Awuor MD, Arsha Shreedhar MD, Ron Julia Jr. MD 2014 Lehigh Valley Health Network

Improving Outcomes In Diabetic Patients, Daniel Tseytlin Do, Cheryl Bloomfield Md, Ranjit R. Nair Md, Carolyn Casey Do, Vlad Vlatsis Do, Maura Bucciarelli Do, Chris Kern Do, Stephen Awuor Md, Arsha Shreedhar Md, Ron Julia Jr. Md

Department of Medicine

No abstract provided.


Progressive Ataxia In An Aids Patient On Antiretroviral Therapy, Misbahuddin Syed MD 2014 Lehigh Valley Health Network

Progressive Ataxia In An Aids Patient On Antiretroviral Therapy, Misbahuddin Syed Md

Department of Medicine

No abstract provided.


Is The United States Prepared For Ebola?, Lawrence O. Gostin, James G. Hodge Jr., Scott Burris 2014 Georgetown University Law Center

Is The United States Prepared For Ebola?, Lawrence O. Gostin, James G. Hodge Jr., Scott Burris

Georgetown Law Faculty Publications and Other Works

The West African Ebola epidemic is a humanitarian crisis and a threat to international security. It is not surprising that isolated cases have emerged in Europe and North America, but a large outbreak in the United States, with its advanced health system, is unlikely. Yet the handling of the first domestically diagnosed Ebola case in Dallas, Texas, raised concerns about national public health preparedness. What were the critical health system vulnerabilities revealed in Dallas, and how can the country respond more effectively to novel diseases in a globalized world?


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