Albany State University, Georgia
James Madison University
University of New Hampshire, Durham
University of Rhode Island
Aurora UW Medical Group
Iowa State University
Department of Neurology, University of Pécs, Hungary
Western University
Identifying The Risk Factors To Postpartum Depression,
2019
Dominican University of California
Identifying The Risk Factors To Postpartum Depression, Jannica Bondoc Santos
Senior Theses and Capstone Projects
A woman’s life instantly changes after the birth of their child. Furthermore, culture influences the stigma that a mother is the primary caregiver of their children and are accountable for the health and upbringing of the child. Giving birth to a baby and taking up the responsibility of another human life is a great impact in a female’s existence. In addition to the new tasks that come with motherhood, women are also challenged to cope with their emotional and mental state after giving birth. The most chronic mental illness that can develop after labor is postpartum depression (PPD ...
Oscillation In Mathematical Epidemiology,
2019
Bates College
Oscillation In Mathematical Epidemiology, Meredith Greer
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Multidisciplinary Education And Research In Biomathematics For Solving Global Challenges,
2019
George Mason University
Multidisciplinary Education And Research In Biomathematics For Solving Global Challenges, Padmanabhan Seshaiyer
Annual Symposium on Biomathematics and Ecology: Education and Research
No abstract provided.
Neverland: A Critical Autoethnography Of Aging With Cystic Fibrosis,
2019
Florida State University College of Medicine
Neverland: A Critical Autoethnography Of Aging With Cystic Fibrosis, Alexandra Ch Nowakowski
The Qualitative Report
In this autoethnography, I analyze stereotypes and misconceptions about people with cystic fibrosis (CF). I examine these illness representations and their social underpinnings through critical analysis of my journey to conclusive diagnosis with CF after first being tested for the disease in early life, and the events that have followed from that turning point. Using experiential data and prior research, I explore and refute harmful misconceptions about life with CF. I challenge the notion that people with CF never grow old. I also contest the idea that people who receive conclusive diagnoses during adulthood only then transition into patient identities ...
Design And Preliminary Findings From A New Electronic Cohort Embedded In The Framingham Heart Study,
2019
University of Massachusetts Medical School
Design And Preliminary Findings From A New Electronic Cohort Embedded In The Framingham Heart Study, David D. Mcmanus, Ludovic Trinquart, Emelia J. Benjamin, Emily S. Manders, Kelsey Fusco, Lindsey S. Jung, Nicole L. Spartano, Vik Kheterpal, Christopher Nowak, Mayank Sardana, Joanne M. Murabito
David D. McManus
BACKGROUND: New models of scalable population-based data collection that integrate digital and mobile health (mHealth) data are necessary.
OBJECTIVE: The aim of this study was to describe a cardiovascular digital and mHealth electronic cohort (e-cohort) embedded in a traditional longitudinal cohort study, the Framingham Heart Study (FHS).
METHODS: We invited eligible and consenting FHS Generation 3 and Omni participants to download the electronic Framingham Heart Study (eFHS) app onto their mobile phones and co-deployed a digital blood pressure (BP) cuff. Thereafter, participants were also offered a smartwatch (Apple Watch). Participants are invited to complete surveys through the eFHS app, to ...
Proteomics Profiling And Risk Of New-Onset Atrial Fibrillation: Framingham Heart Study,
2019
Boston University
Proteomics Profiling And Risk Of New-Onset Atrial Fibrillation: Framingham Heart Study, Darae Ko, Mark D. Benson, Debby Ngo, Qiong Yang, Martin G. Larson, Thomas J. Wang, Ludovic Trinquart, David D. Mcmanus, Steven A. Lubitz, Patrick T. Ellinor, Ramachandran S. Vasan, Robert E. Gerszten, Emelia J. Benjamin, Honghuang Lin
David D. McManus
Background: Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins.
Methods and Results: We performed proteomics assays among participants from the Framingham Heart Study Offspring attending their fifth examination. Plasma protein levels (n=1373) were measured by the SOMAscan proteomic profiling platform. We used robust inference for the Cox proportional hazards model to relate each protein level with incident AF. In addition, we examined the association between AF-related genetic loci and levels of proteins associated with AF. Our study included 1885 participants (mean age 55+/-10 years, 54% women) who had proteomic profiles measured. A ...
A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine,
2019
CUNY School of Public Health
A Mendelian Randomization Study Of Coronary Artery Disease And Three Amino Acids: Alanine, Glycine, And Glutamine, Allan Uribe
Dissertations and Theses
Cardiovascular disease is the leading cause of death worldwide. Coronary Artery Disease (CAD) accounts for the majority of those deaths. Observational studies have identified risk factors that have been helpful in lowering the death rate, including hypertension, high cholesterol, diabetes, smoking, physical inactivity and poor diet. The effects of these risk factors on CAD remain unclear. To clarify the effect of three amino acids, alanine, glutamine, and glycine on CAD I applied a two sample Mendelian randomization analysis to extensively genotyped observational data. In a sample with up to 184,000 individuals and approximately 60,000 controls, SNPs that reached ...
Review Of Chagas Disease And Treatment Obstacles To Eradication,
2019
Liberty University
Review Of Chagas Disease And Treatment Obstacles To Eradication, Emily Sherman
Senior Honors Theses
The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries. The agent of the disease is a single-celled protozoan parasite, Trypanosoma cruzi, and common modes of transmission include infected feces of a triatomine bug, crossing the placental barrier, and blood products. The two phases of infection are acute and chronic, and the three most affected body systems are cardiovascular, digestive, and nervous. Although research has led to several advances in the knowledge of CD, there are gaps in treatment and epidemiological ...
Wake Forest University Long-Term Follow-Up Of Type 2 Myocardial Infarction: The Wake-Up T2mi Registry,
2019
Wake Forest University
Wake Forest University Long-Term Follow-Up Of Type 2 Myocardial Infarction: The Wake-Up T2mi Registry, Hanumantha R. Jogu, Waqas Qureshi
Open Access Articles
BACKGROUND: The Wake-Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate clinical characteristics, management, and short- and long-term outcomes in this high-risk, understudied population.
METHODS: From 1 January 2009 to 31 December 2010, 2846 patients were identified with T2MI or myocardial injury defined as elevated cardiac troponin I with at least one value above the 99th percentile upper reference limit and coefficient of variation of 10% ( > 40 ng/L) and meeting our inclusion criteria. Data of at ...
The Association Between Herpes Simplex Virus Type 1 Reactivation And Alzheimer’S Disease,
2019
Lincoln University, Jefferson City Missouri
The Association Between Herpes Simplex Virus Type 1 Reactivation And Alzheimer’S Disease, Andrew Allee
BIO 410 Spring 2019 Research Papers
This review will focus on the interaction of herpes simplex virus type 1 (HSV-1) and its causative role in pathogenesis of Alzheimer’s disease (AD) noting specifically, the epidemiological relevance of addressing this problem, as well as the molecular pathways associated. HSV-1 reactivation tends to be one of the primary causative events that is responsible for many of the pathologies associated with AD, such as: amyloid beta (Aβ) accumulation caused by malfunctioning cleavage of amyloid precursor protein (APP) as well as tau hyperphosphorylation. HSV-1 reactivation is a primary causative event in downstream dysfunction and is also shown to be directed ...
The Effects Of A Low-Glycemic Index Diabetes Management Program On Weight, Body Mass Index, Triglycerides, Cholesterol And Hemoglobin A1c Values,
2019
Louisiana Tech University
The Effects Of A Low-Glycemic Index Diabetes Management Program On Weight, Body Mass Index, Triglycerides, Cholesterol And Hemoglobin A1c Values, Morgan Williston
Master's Theses
The purpose of this study was to evaluate effects of a low-glycemic index diet on weight, body mass index (BMI), triglycerides, cholesterol levels, and hemoglobin A1c
(HbA1c) following participation in a 12-hour outpatient diabetes self- management education (DSME) program. This DSME program is unique as it
focuses on a low-glycemic index diet rather than the traditional carbohydrate consistent diet to control blood glucose levels. Health outcomes obtained post participation were compared to baseline data. Participants were 283 individuals with type 2 diabetes including 94 (33%) men and 189 (67%) women, with a mean baseline HbA1c of 8.7 ±2.2 ...
Shingles Vaccine: Identifying High Risk Groups In The Ibd Clinic Setting,
2019
University of San Diego
Shingles Vaccine: Identifying High Risk Groups In The Ibd Clinic Setting, Crystal Barajas
Doctor of Nursing Practice Final Manuscripts
Title: Shingles Vaccine: Identifying high risk groups in the IBD clinic setting
Background: The Inflammatory Bowel Disease (IBD) population is an immunocompromised patient population who is at risk for Herpes Zoster (HZ) due to their medication regimen, which further compromises their immune system. It can be difficult for patients to receive appropriate preventative health maintenance measures due to patients’ fears, primary care providers’ lack of knowledge, and gastroenterologists not addressing what may be considered primary care topics. Furthermore, evidence demonstrates that IBD patients have low vaccination rates despite insurance coverage.
Purpose of Project: (a) To increase awareness of the importance ...
The Roles Of An Evidence-Based Weight Management Protocol In Hypertension Control,
2019
University of San Diego
The Roles Of An Evidence-Based Weight Management Protocol In Hypertension Control, Belinda Akakpo Maxwell
Doctor of Nursing Practice Final Manuscripts
The Roles of an Evidence-Based Weight Management Protocol in Hypertension Control
Abstract
Purpose: The purpose of this project is to evaluate the impact of a healthcare provider-led protocol for patients with hypertension (HTN) and weight loss needs to improve weight control, cardiovascular risk and quality of life.
Background: Evidence shows that a 1.2-kg weight loss can reduce systolic blood pressure (SBP) by 3.8mmHg. Thus, a 10kg (22lbs) weight loss is likely to yield a SBP decrease of as much as 32mmHg. Such results would positively impact quality of life and costs. The simple approach of instructing patients to ...
Genetic Discrimination: Why Bragdondoes Not Ensure Protection,
2019
Selected Works
Genetic Discrimination: Why Bragdondoes Not Ensure Protection, Laura F. Rothstein
Laura Rothstein
No abstract provided.
Sub-Region Based Radiomics Analysis For Survival Prediction In Oesophageal Tumours Treated By Definitive Concurrent Chemoradiotherapy,
2019
Wenzhou Medical University
Sub-Region Based Radiomics Analysis For Survival Prediction In Oesophageal Tumours Treated By Definitive Concurrent Chemoradiotherapy, Congying Xie, Pengfei Yang, Xuebang Zhang, Lei Xu, Xiaoju Wang, Xiadong Li, Luhan Zhang, Ruifei Xie, Ling Yang, Zhao Jing, Hongfang Zhang, Lingyu Ding, Yu Kuang, Tianye Niu, Shixiu Wu
Health Physics & Diagnostic Sciences Faculty Publications
Background: Evaluating clinical outcome prior to concurrent chemoradiotherapy remains challenging for oesophageal squamous cell carcinoma (OSCC) as traditional prognostic markers are assessed at the completion of treatment. Herein, we investigated the potential of using sub-region radiomics as a novel tumour biomarker in predicting overall survival of OSCC patients treated by concurrent chemoradiotherapy. Methods: Independent patient cohorts from two hospitals were included for training (n = 87) and validation (n = 46). Radiomics features were extracted from sub-regions clustered from patients' tumour regions using K-means method. The LASSO regression for ‘Cox’ method was used for feature selection. The survival prediction model was constructed ...
The Effects Of Autophagy On The Replication Of Zika Virus,
2019
Touro College and University System
The Effects Of Autophagy On The Replication Of Zika Virus, Mohammed Marghani
NYMC Student Theses and Dissertations
Zika virus is an enveloped virus with a single-stranded positive-sense RNA genome. The Zika virus is a member of the Flaviviridae family of viruses that was discovered to infect humans in 1952. The Flavivirus envelope is decorated by many copies of two membrane proteins that facilitate viral entry. The virus is primarily transmitted through mosquito bites. Another method by which Zika virus could be transmitted is through sexual contact with Zika infected partners or from an infected pregnant woman to fetus known as congenital transmission. Infected patients suffer from self-limiting febrile illness including headaches, skin rash myalgia, and conjunctivitis. Zika ...
The Impact Of Cleft Lip/Palate And Clp Surgical Intervention On The Social Integration Of Adolescents In India,
2019
The University of San Francisco
The Impact Of Cleft Lip/Palate And Clp Surgical Intervention On The Social Integration Of Adolescents In India, Mustafa Zahid
Master's Theses
Cleft Lip/Palate, a congenital orofacial anomaly, carries an incidence rate of approximately 1 in every 1000 births. In addition to the stigma associated with the condition, the varying levels of cleft severity might result in lower life outcomes which could include lower cognitive ability, physical and psychological well-being, social and behavioral outcomes of adolescents. This paper focuses on the social integration element of life outcomes, which is composed of the social inclusion and prosocial behavior of the adolescent. Despite the affordability of restorative surgeries, patients in rural areas of Low and Middle-Income Countries (LMICs) such as India face accessibility ...
Characterizing The Permanence And Stationary Distribution For A Family Of Malaria Stochastic Models,
2019
Virginia Commonwealth University
Characterizing The Permanence And Stationary Distribution For A Family Of Malaria Stochastic Models, Divine Wanduku
Biology and Medicine Through Mathematics Conference
No abstract provided.
Conserved, Breed-Dependent, And Subline-Dependent Innate Immune Responses Of Fayoumi And Leghorn Chicken Embryos To Newcastle Disease Virus Infection,
2019
The Pennsylvania State University
Conserved, Breed-Dependent, And Subline-Dependent Innate Immune Responses Of Fayoumi And Leghorn Chicken Embryos To Newcastle Disease Virus Infection, Megan A. Schilling, Sahar Memari, Meredith Cavanaugh, Robab Katani, Melissa S. Deist, Jessica Radzio-Basu, Susan J. Lamont, Joram J. Buza, Vivek Kapur
Susan J. Lamont
Newcastle disease virus (NDV) is a threat to the global poultry industry, but particularly for smallholder farmers in low- and middle-income countries. Previous reports suggest that some breeds of chickens are less susceptible to NDV infection, however, the mechanisms contributing to this are unknown. We here examined the comparative transcriptional responses of innate immune genes to NDV infection in inbred sublines of the Fayoumi and Leghorn breeds known to differ in their relative susceptibility to infection as well as at the microchromosome bearing the major histocompatability complex (MHC) locus. The analysis identified a set of five core genes, Mx1, IRF1 ...
Detection Of Bleeding Events In Electronic Health Record Notes Using Convolutional Neural Network Models Enhanced With Recurrent Neural Network Autoencoders: Deep Learning Approach,
2019
University of Massachusetts Amherst
Detection Of Bleeding Events In Electronic Health Record Notes Using Convolutional Neural Network Models Enhanced With Recurrent Neural Network Autoencoders: Deep Learning Approach, Rumeng Li, Baotian Hu, Feifan Liu, Weisong Liu, Francesca Cunningham, David D. Mcmanus, Hong Yu
David D. McManus
BACKGROUND: Bleeding events are common and critical and may cause significant morbidity and mortality. High incidences of bleeding events are associated with cardiovascular disease in patients on anticoagulant therapy. Prompt and accurate detection of bleeding events is essential to prevent serious consequences. As bleeding events are often described in clinical notes, automatic detection of bleeding events from electronic health record (EHR) notes may improve drug-safety surveillance and pharmacovigilance.
OBJECTIVE: We aimed to develop a natural language processing (NLP) system to automatically classify whether an EHR note sentence contains a bleeding event.
METHODS: We expert annotated 878 EHR notes (76,577 ...
