Diseases Commons^™

Session 12: Active Learning To Minimize The Possible Risk From Future Epidemics, Kc Santosh

SDSU Data Science Symposium

In medical imaging informatics, for any future epidemics (e.g., Covid-19), deep learning (DL) models are of no use as they require a large dataset as they take months and even years to collect enough data (with annotations). In such a context, active learning (or human/expert-in-the-loop) is the must, where a machine can learn from the first day with minimum possible labeled data. In unsupervised learning, we propose to build pre-trained DL models that iteratively learn independently over time, where human/expert intervenes only when it makes mistakes and for only a limited data. In our work, deep features are used to …

A Brief Overview Of Triple A Syndrome, Jamaal Khan

Mako: NSU Undergraduate Student Journal

Triple A Syndrome, also known as AAA Syndrome, is a rare autosomal recessive disorder caused by any mutation in the AAAS gene on chromosome 12q13, whose main function is to code for the WD-repeat family regulatory protein, ALADIN. It typically occurs as a group of diseases that are characterized by alacrima, Addison's disease, and achalasia. Alacrima can be defined by a decrease in the amount of tears produced while achalasia is nerve damage in the esophagus that can cause difficulty swallowing. Lastly, Addison's disease is the insufficient production of cortisol and aldosterone produced by the adrenal cortex. There is no …

Recurrent Cyanotic Spells In An Octogenarian, Chin Tong Kwok, Chun Kit Wong

Journal of the Hong Kong College of Cardiology

We report rare case of an octogenarian who, after years of diagnostic delay, was found to have a patent foramen ovale, and due to an ascending aortic aneurysm that anatomically facilitated right-to-left shunt, presenting with life-threatening cyanotic attacks. The characteristic orthodeoxia-platypnea syndrome and high alveolar arterial gradient hint to the diagnosis. She was eventually treated successfully with urgent percutaneous PFO closure. Routine ordering of a transthoracic echocardiogram, without agitated saline injection under provocation maneuvers, may not be sufficient to rule out shunts.

Roles Of Exercise Treadmill Test In The Diagnosis & Risk Stratification Of Cardiac Channelopathies, Kit Chan

Journal of the Hong Kong College of Cardiology

Channelopathies are the leading causes of SCD in patients without structural heart disease. Missing the diagnosis of high-risk but concealed channelopathies could have lethal clinical consequences. However, the diagnosis of channelopathies is often challenging due to the dynamic clinical presentations and elusive ECG manifestations of these diseases. An integrated approach including clinical assessment, repeated electrocardiography, drug provocation tests, exercise stress test and genetic studies is often required for establishing the diagnosis. Pharmacological provocation tests may have limited sensitivity and may be associated with false positive results. Wide-spread use of genetic studies are limited by low yield, cost-effectiveness and availability issue. …

Retrospective Observational Study Comparing Two Reperfusion Strategies In Patients With Acute Stemi Presenting Outside Office Hours, Derek Pok-Him Lee, Kam-Tim Chan, Michael Kang-Yin Lee, Eric Chi-Yuen Wong

Journal of the Hong Kong College of Cardiology

Introduction : A pilot cluster-based 24-hour PPCI service in a phased expansion program was launched in October 2018. This study aimed to compare the 30-day mortality and major bleeding event in acute STEMI patients presenting outside office hours who received historical thrombolytic therapy and PPCI under the newly implemented 24-hour service model. Methods and results : A single center retrospective study was conducted on consecutive STEMI patients presenting outside office hours, who received urgent thrombolytic therapy or PPCI between 2016-2019. The primary endpoints were 30-day mortality and major bleeding event. The secondary endpoints were thrombolytic failure rate and hospital length …

The Impact Of Renal Insufficiency Upon Admission On The Clinical Outcome Of Patients With Acute St-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention, Wai Lun Kwong, Kwok Ho Yau, Eugene Sin, Kwok Keung Chan

Journal of the Hong Kong College of Cardiology

Background: Coronary artery disease is common in patients with renal insufficiency. In acute coronary syndrome, impaired renal function is present in approximately 30-40% of patients and is associated with worse prognosis. Local data regarding the risks and benefits for those patients suffering from acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) is scarce. We evaluated the clinical outcomes of patients suffering from STEMI with and without renal insufficiency upon admission who underwent PPCI.

Methods: From 1^st January 2009 to 30^th September 2017, all patients with STEMI treated with PPCI were identified. The primary …

A Rodent Model For Dirofilaria Immitis, Canine Heartworm: Parasite Growth, Development, And Drug Sensitivity In Nsg Mice, Jessica A. Hess, Mark L. Eberhard, Marcelo Segura-Lepe, Kathrin Grundner-Culemann, Barbara Kracher, Jeffrey Shryock, John Harrington, David Abraham

Department of Microbiology and Immunology Faculty Papers

Heartworm disease, caused by Dirofilaria immitis, remains a significant threat to canines and felines. The development of parasites resistant to macrocyclic lactones (ML) has created a significant challenge to the control of the infection. The goal of this study was to determine if mice lacking a functional immune response would be susceptible to D. immitis. Immunodeficient NSG mice were susceptible to the infection, sustaining parasites for at least 15 weeks, with infective third-stage larvae molting and developing into the late fourth-stage larvae. Proteomic analysis of host responses to the infection revealed a complex pattern of changes after infection, with at …

Impact Of Perioperative Dexamethasone On Hospital Length Of Stay And Glycemic Control In Patients With Type 2 Diabetes Undergoing Total Hip Arthroplasty, Vanessa Williams, Mohammad J. Uddin Ansari, Amruta Jaju, Stacey Ward, Daniel O'Keefe, Jumana Abdelkarim, Nicole Montes, Ula Tarabichi, Albert Botchway, Michael G. Jakoby Iv

Journal of Patient-Centered Research and Reviews

Purpose: This study aimed to evaluate effects of perioperative dexamethasone on hospital length of stay (LOS) and glycemic control for patients with type 2 diabetes mellitus undergoing total hip arthroplasty (THA).

Methods: We performed retrospective case review of THA performed in adults (≥ 18 years old) with type 2 diabetes at Springfield Memorial Hospital (Springfield, IL) immediately before (2013), during (2014), and after (2015) publication of consensus guidelines for use of perioperative dexamethasone. Hospital LOS was the primary endpoint. Capillary blood glucose by hospital day, proportion of patients treated with insulin, and median insulin dose by hospital day …

Understanding Quality Of Life In Patients With Acute Leukemia, A Global Survey, Zack Pemberton-Whiteley, Samantha Nier, Jan Geissler, Sophie Wintrich, Bregje Verhoeven, Rita O. Christensen, Sam Salek, Esther Natalie Oliva, Tatyana Ionova, Jennie Bradley

Journal of Patient-Centered Research and Reviews

Purpose: The Acute Leukemia Advocates Network (ALAN) sought to determine which factors are most associated with poor quality of life (QoL) in patients with acute leukemia and to determine key issues and unmet needs through administration of an online survey distributed worldwide via partner patient organizations.

Methods: ALAN developed a questionnaire informed by literature review and based extensively on the hematological malignancy-specific patient-reported outcomes (HM-PRO) measure to assess the impact of acute leukemia on QoL and its relationships with patients’ demographics, disease state, disease impact, and support from health care professionals. Univariate and multivariable statistical analysis was used to investigate …

Treatment Outcome Of Rhino-Orbital-Cerebral Mucormycosis Patients: A Retrospective Institutional Study, Nishant S. Saxsenaa, Amrita Srivastavaa, Madhu Yadav, S.K. Kanaujia, H.K. Gautama, Shalani Tripathia, Shaleem Khana, Tripti Agrwala

Pan Arab Journal of Rhinology

Introduction Rhino-orbital-cerebral mucormycosis is an acute fungal infection characterized by fungal hyphal invasion of blood vessels resulting in thrombosis and infarction of the nasal, paranasal sinus, orbital, and cerebral tissues. Patients and methods This was a retrospective study conducted on 80 patients with biopsy-proven mucormycosis. The study was carried out in the Mucormycosis Ward of a Tertiary Care Medical College and Hospital during a period of 6 months from May 2021 to October 2021. Results Among 80 patients, 50 (62.5%) were males and 37 (37.5. %) were females. Of the patients, 53.75% were in the age group of 51–70 years. …

Editorial, Reda Kamela, Ahmed El-Faroukb

Pan Arab Journal of Rhinology

No abstract provided.

Chronic Qat Chewing Effects On Nasopharynx, Oropharynx, And Laryngopharynx, Ahmed Mahmoud El Batawi, Ahmad M. Eltelety, Mohamed Abd Elmottaleb Sabaa

Pan Arab Journal of Rhinology

Background Qat (also known as Khat, Kat, Miraa) is a green plant Catha edulis planted mainly in East and South Africa, and The Arabian Peninsula. It is widely and traditionally consumed by people in some regions. It has general effects on different systems such as cardiovascular and nervous system. Local effects were mainly described in the oral cavity such as periodontitis and white keratotic lesions. Scarce studies proved its relationship with cancer development. To date, there is a literature gap in reporting other local manifestations. In this study, the authors discuss additional local manifestations noted with chronic qat chewing. Aim …

Outcomes Of Middle Turbinate-Septal Adhesion Technique And Trans-Septal Middle Turbinate Suture Technique To Prevent Middle Turbinate Lateralization: A Comparative Study, Muaid I. Aziz Baban, Hiwa A. Rawandizi, Hozan F. Ali, Sahar J. Hadi, Shkar N. Mohammed

Pan Arab Journal of Rhinology

Background Middle turbinate lateralization (MTL) is the most common undesirable sequela after functional endoscopic sinus surgery (FESS), which can result in recurrent sinusitis. Objectives To examine the efficacy and outcomes of different techniques to prevent failure of the primary surgery. Patients and methods Eighty patients who presented with chronic rhinosinusitis listed for FESS were enrolled in this study. Patients were divided randomly into two groups, with 40 patients each. In group A, middle turbinate (MT) was stabilized by adhesion technique, and in group B, MT was stabilized via suture technique. A comparison of the effectiveness and the outcomes of both …

Topical Application Versus Intraturbinate Injection Of Botulinum Toxin Type A In The Treatment Of Noninfectious Chronic Rhinosinusitis, Naslshah G. Kazem, Mohamed A. Elsaid, Aya L. Hassan, Abdelrahman A. Abdelalim

Pan Arab Journal of Rhinology

Background Chronic rhinosinusitis is a very common disorder caused by chronic inflammation or irritation of nasal mucosa. Objectives The purpose of this study was to evaluate the efficacy and safety of topical application of botulinum toxin type A (BTX-A) compared with intraturbinate injection for the treatment of noninfectious chronic rhinosinusitis. Patients and methods This prospective comparative study was carried out on 30 patients with noninfectious chronic rhinosinusitis. Patients were divided randomly into two groups. BTX-soaked merocel was applied topically in group A (topical group), which included 15 patients. Intraturbinate BTX injection was applied in group B (injected group), which included …

Review Of First 60 Pituitary Adenoma Cases Of A Skull Base Team, One Center Experience, Osama Hassan, Mohamed Fatthallah, Mohamed El Mallawany

Pan Arab Journal of Rhinology

Background: Endoscopic endonasal transsphenoid approach of pituitary gland is being effectively replacing microscopic approach. This approach need a lot of training and stepwise learning to reach perfection. This study discuss the experience and pitfalls of an evolving skull base team in one institute. Aim of the work: Analysis of first sixty pituitary adenomas patients operated by an evolving skull base teams in one institute, and highlighting modifications introduced in their technique. Methodology: This is a retrospective analytical study of the medical records of first 60 pituitary adenoma patients who had presented to one center and had endoscopic trans-nasal trans-sphenoidal approach …

Anosmia And/Or Ageusia In Coronavirus Disease 2019-Infected Patients: Role Of Early Corticosteroids And Timeline, Naslshah G. Kazema, Emad R.H. Issakb

Pan Arab Journal of Rhinology

Aim An increasing number of coronavirus disease 2019 (COVID-19) cases have started to experience unusual symptoms to the virus such as olfactory and gustatory dysfunctions. The study aimed to compare the effects of early corticosteroids (CS) administration versus no administration in the time-to-recovery from olfactory dysfunction in COVID-19. Patients and methods This comparative, nonrandomized study has been conducted at Benha University Hospital and another Primary Health Center in Cairo, Egypt, from January 2021 to June 2021. A total of 83 patients who have met the inclusion criteria were assigned into two groups: early-CS group (41 cases) and no-CS group (42 …

Evaluating The Association Between Depressive Symptoms And Glycemic Control Among Residents Of Rural Appalachia, Brittany L. Smalls, Adebola Adegboyega, Ellen Combs, Eli W. Travis, Felipe De La Barra, Lovoria B. Williams, Nancy Schoenberg

Journal of Appalachian Health

Introduction: Type 2 diabetes mellitus (T2DM) is associated with a range of co-morbid physical and psychological conditions, including depression. Yet there is a dearth of evidence regarding the prevalence of depression among those in Appalachia living with T2DM; this gap persists despite the higher regional prevalence of T2DM and challenging social determinants of health.

Purpose: This study aimed to provide greater detail about the relationships between T2DM and depressive symptoms in adults living in Appalachia Kentucky.

Methods: The present study was a cross-sectional analysis of baseline data derived from an ongoing study of Appalachia Kentucky adults living with T2DM. Outcome …

African American And Caucasian Perceptions And Attitudes Toward Colorectal Cancer Screening: A Qualitative Study, Peter Warren, Stacie Pankow, Yvette Rother, Peggy Wagner

The Qualitative Report

This study examined the attitudes held by both African Americans and Caucasians regarding colorectal cancer screening and the reasons why they avoid screenings even when clinically indicated by their physicians. Colorectal cancer (CRC) is one of the most common and easily preventable types of cancer in the United States. If diagnosed and treated early prior to metastasis, the five-year colorectal cancer survival rate is approximately 90%. However, many patients avoid screening procedures for colorectal cancer due to a number of reasons. Qualitative data was gathered from focus groups and found four major themes that emerged in both groups: (1) reported …

The Effectiveness Of Pay-It-Forward In Addressing Hpv Vaccine Delay And Increasing Uptake Among 15–18-Year-Old Adolescent Girls Compared To User-Paid Vaccination: A Study Protocol For A Two-Arm Randomized Controlled Trial In China, Yifan Li, Chuanyu Qin, Shengyue Qiu, Yu He, Linchuan Pang, Xiaolan Xu, Vivian Wan-Cheong Yim, Shenglan Tang, Heng Du, Wenfeng Gong, Fan Yang, Joseph D. Tucker, Weiming Tang, Yun Wang, Leesa Lin, Mark Jit, Wei Song, Chunrong Li, Jennifer Smith, Jing Li, Dan Wu

Pharmacy Faculty Articles and Research

Background

Human papillomavirus (HPV) vaccination could prevent cervical and other HPV-associated cancers attributable to vaccine-associated HPV types. However, HPV vaccination coverage among women aged 9–18 years old is low in China. Common barriers include poor financial affordability, minimal public engagement, and low confidence in domestically produced HPV vaccines. Pay-it-forward offers an individual a free or subsidized service then an opportunity to voluntarily donate and/or create a postcard message to support future people. This study aims to assess the effectiveness of pay-it-forward as compared to standard-of-care self-paid vaccination to improve HPV vaccine uptake among adolescent girls aged 15–18 years, who are …

Reliability Of Hand-Held Dynamometry For Measuring Force Production In People With Parkinson’S Disease, Matthew Boom, Elisabeth Preston, Renee Salmon, Louise Ada, Allyson Flynn

Internet Journal of Allied Health Sciences and Practice

Purpose: People with Parkinson’s disease (PD) have impaired force production, which is associated with decreased mobility and falls risk. Reliable measurement of force production is important. Design: A repeated-measures, intra- and inter-rater reliability study was undertaken. Participants: 24 people with mild PD were measured by one or two raters. Outcome measures: Isometric force of the major upper and lower limb muscle groups was measured using hand-held dynamometry. Results: Fourteen participants were measured by the same rater on two occasions to determine intra-rater reliability. Ten participants were measured on two occasions by two different raters to determine …