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Human Trafficking, Katelyn H. Kennedy, Kylie S. Dobbs, Hannah L. Peters 2017 Cedarville University

Human Trafficking, Katelyn H. Kennedy, Kylie S. Dobbs, Hannah L. Peters

Introduction to Public Health Posters

Human trafficking is a current problem that health professionals, such as pharmacists, should be aware of. This poster was created as a group project by pre-pharmacy majors and exhibited to faculty and graduate pharmacy students. The primary purpose of the project was to learn about human trafficking as a public health concern, increase awareness, and search for ways to reduce the problem. The poster highlights the different forms of human trafficking and what determinants of health apply to this problem. It also seeks to show how human trafficking relates to the pharmacy profession.


Texting And Driving: A Grave Mistake, Hayley Trout, Faith Stewart, Zachariah Bevins, Kortney Frederick 2017 Cedarville University

Texting And Driving: A Grave Mistake, Hayley Trout, Faith Stewart, Zachariah Bevins, Kortney Frederick

Introduction to Public Health Posters

Texting and driving is a more prevalent problem today than most people realize. Even worse is the fact that it's even a problem for those who drive safely; those around them aren't always making the same choices. Some groups of people are more likely to drive than others depending on social factors, individual behavior choices, policy, and biology and genetics. While this might not have anything to do with prescriptions, it does have to do with pharmacy. A pharmacist is responsible for educating the community and keeping those within it healthy. They have the potential to make a ...


Antibiotic Resistance, Karley J. Trow, Parker N. Savard, MaryLou Mumme, Brandon M. Christen 2017 Cedarville University

Antibiotic Resistance, Karley J. Trow, Parker N. Savard, Marylou Mumme, Brandon M. Christen

Introduction to Public Health Posters

Our poster discusses an overview of antibiotic resistance. It goes into detail about what it is, how it came to be, and what medical professionals can do in their attempt to prevent it, as well as the general public. It also discusses the impact the impact antibiotic resistance has had on pharmacy, as well as the science behind it. A few organizations working towards this problem, and who keep a close eye on this issue are mentioned as well. We also discuss the determinants of health, which is essentially what is being done about it politically, individually, and the health ...


The Great Pacific Garbage Patch, Andrew Barnhart, Lawrence Bisong, Mckenzie Brittenham, Emma Eccher 2017 Cedarville University

The Great Pacific Garbage Patch, Andrew Barnhart, Lawrence Bisong, Mckenzie Brittenham, Emma Eccher

Introduction to Public Health Posters

Waste and where it ends up is not a common discussion topic; in fact, it is often treated as a taboo subject. However, it has become necessary to examine this topic due to the growing ecological problems caused by the collection of garbage within our oceans. The Great Pacific Garbage patch, in particular, has grown quite large, and it is now affecting the health of people. This poster explores the ramifications of the Great Pacific Garbage Patch. It discusses the background of the garbage patches and the impact of the issue. It also mentions the different determinants of health that ...


Opioid Abuse In America, Alexander Goodridge, Dalton L. Lewis, Grant B. Middleton, Rachel L. Wolthoff 2017 Cedarville University

Opioid Abuse In America, Alexander Goodridge, Dalton L. Lewis, Grant B. Middleton, Rachel L. Wolthoff

Introduction to Public Health Posters

This poster examines the Opioid Abuse crisis in the United States as a whole, the poster will go into detail on the Impact the Opioid Epidemic is having on Pharmacy as well as the citizens whom are being impacted. The Poster will dive further into detail on the Policies that have impacted this Epidemic as well as where the epidemic is happen most readily. Most of all though the poster will take a look at what Pharmacists and other health professionals can do to help and better equip their patients in battling this epidemic.


Simplified Reversed Chloroquines To Overcome Malaria Resistance To Quinoline-Based Drugs, Bornface Gunsaru, Steven J. Burgess, Westin Morrill, Jane X. Kelly, Shawheen Shomloo, Martin J. Smilkstein, Katherine May Liebman, David H. Peyton 2017 Portland State University

Simplified Reversed Chloroquines To Overcome Malaria Resistance To Quinoline-Based Drugs, Bornface Gunsaru, Steven J. Burgess, Westin Morrill, Jane X. Kelly, Shawheen Shomloo, Martin J. Smilkstein, Katherine May Liebman, David H. Peyton

David H. Peyton

Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from in vitro heme binding and beta-hematin inhibition assays suggest that the single aromatic RCQ compounds retain activities against Plasmodium falciparum similar to those of CQ, although other mechanisms of action may be relevant to their activities.


Ensemble-Based Modeling And Rigidity Decomposition Of Allosteric Interaction Networks And Communication Pathways In Cyclin-Dependent Kinases: Differentiating Kinase Clients Of The Hsp90-Cdc37 Chaperone, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker 2017 Chapman University

Ensemble-Based Modeling And Rigidity Decomposition Of Allosteric Interaction Networks And Communication Pathways In Cyclin-Dependent Kinases: Differentiating Kinase Clients Of The Hsp90-Cdc37 Chaperone, Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The overarching goal of delineating molecular principles underlying differentiation of protein kinase clients and chaperone-based modulation of kinase activity is fundamental to understanding activity of many oncogenic kinases that require chaperoning of Hsp70 and Hsp90 systems to attain a functionally competent active form. Despite structural similarities and common activation mechanisms shared by cyclin-dependent kinase (CDK) proteins, members of this family can exhibit vastly different chaperone preferences. The molecular determinants underlying chaperone dependencies of protein kinases are not fully understood as structurally similar kinases may often elicit distinct regulatory responses to the chaperone. The regulatory divergences observed for members of CDK ...


Computational Study Targeting Anti-Fungal Tavaborole Analogs And Anti-Cancer Braco19, Babitha Machireddy 2017 Rowan University

Computational Study Targeting Anti-Fungal Tavaborole Analogs And Anti-Cancer Braco19, Babitha Machireddy

Theses and Dissertations

This thesis comprises of three computer aided drug design studies utilizing molecular docking and molecular dynamic simulations: (i) a lead optimization study virtually screening an initial library of ~120000 lead compounds targeting fungal leucyl tRNA synthetase, (ii) an exploratory study to understand the binding pathway of BRACO19 to a parallel telomeric DNA G-quadruplex by MD simulations and compare with experimentally solved X-ray crystal structure (iii) a comparative study to understand the lack of selectivity of BRACO19 to various topologies of human telomeric DNA G-quadruplex over DNA duplex.

The first chapter provides the background information required to understand the molecular docking ...


Evaluating Patient Preferences For Different Incentive Programs To Optimize Pharmacist-Provided Patient Care Program Enrollment, Daniel M. Tomaszewski, Tim Cernohaus, Rajiv Vaidyanathan 2017 Chapman University

Evaluating Patient Preferences For Different Incentive Programs To Optimize Pharmacist-Provided Patient Care Program Enrollment, Daniel M. Tomaszewski, Tim Cernohaus, Rajiv Vaidyanathan

Pharmacy Faculty Articles and Research

BACKGROUND: Employers have increased efforts to engage employees in health and wellness programs. Providing employees with incentives to participate in these programs has been shown to improve overall enrollment and engagement. One program that has had challenges with enrollment and engagement is medication therapy management (MTM).

OBJECTIVES: To (a) determine how individuals evaluate different financial incentives to improve participation in an MTM program and (b) measure the effect of participant characteristics on incentive preference.

METHODS: This study was composed of a paper-based survey administered to participants after focus group sessions. Participants included MTMeligible beneficiaries from 2 employer groups and included ...


Student Pharmacists And Street Children: A Mutually Beneficial Relationship, Mario A. Hoyos, Monica L. Miller, Ellen M. Schellhase, C. Ryan Tomlin, Sonak Pastakia, Samuel Kimani, Tim Mercer 2017 Purdue University

Student Pharmacists And Street Children: A Mutually Beneficial Relationship, Mario A. Hoyos, Monica L. Miller, Ellen M. Schellhase, C. Ryan Tomlin, Sonak Pastakia, Samuel Kimani, Tim Mercer

Purdue Journal of Service-Learning and International Engagement

The Tumaini Children’s Drop-In Center is a daytime drop-in center for the street children of Eldoret, Kenya. It is part of a partnership between the Purdue University College of Pharmacy, the Academic Model Providing Access to Healthcare program, Eldoret community members, and numerous individuals in both Kenya and the US. Through the efforts of local staff and Purdue student pharmacists, who work at the local hospital on an eight-week clinical rotation, the center has helped a population of nearly 400 local street children by providing a safe haven from life on the streets. Purdue student pharmacists aid the center ...


A Course On Patient Safety: Pharmacy Student And Community Partner Perceptions, Maryam Noureldin, Chelsea M. Anderson, Patricia L. Darbishire 2017 Purdue University

A Course On Patient Safety: Pharmacy Student And Community Partner Perceptions, Maryam Noureldin, Chelsea M. Anderson, Patricia L. Darbishire

Purdue Journal of Service-Learning and International Engagement

The authors of this article developed and piloted a three-week intensive elective course for students in their third professional years in the Doctor of Pharmacy program. The goal of this course was to provide students with an opportunity to apply patient safety concepts in a real-world setting using service-learning as the pedagogy and to evaluate student perceptions of the course for potential implementation in the curriculum. Seven pharmacy students were enrolled in the pilot course and divided into three groups. Each group of two to three students was assigned to one of three predetermined community partner sites. Students were instructed ...


Expanding The Horizon: Global Health Management For Pharmacy Students, Alice C. Chang, Monica L. Miller, Ellen M. Schellhase 2017 Purdue University

Expanding The Horizon: Global Health Management For Pharmacy Students, Alice C. Chang, Monica L. Miller, Ellen M. Schellhase

Purdue Journal of Service-Learning and International Engagement

The advancement of global engagement opportunities will promote pharmacy students’ cultural awareness and sensitivity, expose students to treatment of diseases not commonly seen in modern Western medicine, and cultivate future leadership for the growth of global pharmacy practice. At Purdue University College of Pharmacy (PUCOP), limited opportunities exist for student pharmacists. As a result, identifying the needs and expanding student pharmacist access to global engagement experiences are critical to meet the changing needs of the US population. A survey was developed and distributed to 460 students at PUCOP, and 148 of them participated. Of those students, 89.2% were interested ...


Addressing A Need: Applying Classroom Knowledge And Skills In A National Pharmacy Chain, Evan Schmidt, Phu Vo 2017 Purdue University

Addressing A Need: Applying Classroom Knowledge And Skills In A National Pharmacy Chain, Evan Schmidt, Phu Vo

Purdue Journal of Service-Learning and International Engagement

Evan Schmidt and Phu Vo, third-year PharmD students in the Purdue College of Pharmacy describe their experiences at Walgreens Pharmacy in Lafayette, Indiana, as part of taking the Safety and Service-Learning elective at Purdue. The students discuss the potential impact they can have by utilizing their knowledge to address a need in a national pharmacy chain, as well as what they took away from the experience.


Patient Care: The Forefront Of Pharmacy Practice, Dakota L. Richart 2017 Purdue University

Patient Care: The Forefront Of Pharmacy Practice, Dakota L. Richart

Purdue Journal of Service-Learning and International Engagement

For the past three years, Richart has been a member of APhA–ASP and has actively participated in numerous events. She planned, organized, and executed health fairs, educational presentations, and other direct patient care experiences alongside other members. An interaction as simple as a five-minute discussion with a patient about their blood pressure, antihypertensive medications, and lifestyle modifications can help save their life. Each patient interaction has impacted her by strengthening her communication skills, developing her professionalism, and providing confidence as she applies her knowledge with patients. Whether APhA–ASP’s events focus on a small audience at a local ...


Difatty Acyl-Conjugated Linear And Cyclic Peptides For Sirna Delivery, Hung Do, Meenakshi Sharma, Naglaa Salem El-Sayed, Parvin Mahdipoor, Emira Bousoik, Keykavous Parang, Hamidreza Montazeri Aliabadi 2017 Chapman University

Difatty Acyl-Conjugated Linear And Cyclic Peptides For Sirna Delivery, Hung Do, Meenakshi Sharma, Naglaa Salem El-Sayed, Parvin Mahdipoor, Emira Bousoik, Keykavous Parang, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

A number of amphiphilic difatty acyl linear and cyclic R5K2 peptide conjugates were synthesized by solid-phase peptide methods to enhance the interaction with the hydrophobic cellular phospholipid bilayer and to improve siRNA delivery and silencing. Binding to siRNA molecules was significantly less for the cyclic peptide conjugates. A gradual decrease was observed in the particle size of the complexes with increasing peptide/siRNA ratio for most of the synthesized peptides, suggesting the complex formation. Most of the complexes showed a particle size of less than 200 nm, which is considered an appropriate size for in vitro siRNA delivery. A number ...


Compositions And Methods Of Modulating 15-Pgdh Activity, Sanford Markowitz, James K. V. Willson, Bruce A. Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai 2017 University of Kentucky

Compositions And Methods Of Modulating 15-Pgdh Activity, Sanford Markowitz, James K. V. Willson, Bruce A. Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, Kibeom Bae, Sung Yeun Yang, Amar Desai

Pharmaceutical Sciences Faculty Patents

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.


Pharmacy Practice And The Michigan Immunization Registry: Results From A Multi-Organizational Collaborative Study, Jeff Goad, Albert Bach 2017 Chapman University

Pharmacy Practice And The Michigan Immunization Registry: Results From A Multi-Organizational Collaborative Study, Jeff Goad, Albert Bach

Jeff Goad

No abstract provided.


Role Of Microglial Amylin Receptors In Mediating Beta Amyloid (Aβ)-Induced Inflammation, Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas 2017 University of Alberta

Role Of Microglial Amylin Receptors In Mediating Beta Amyloid (Aβ)-Induced Inflammation, Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David Mactavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamandas

Pharmacy Faculty Articles and Research

Background: Neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of Alzheimer’s disease (AD) pathology. Amyloid beta (Aβ) protein is known to activate microglia and unleash an inflammatory cascade that eventually results in neuronal dysfunction and death. In this study, we sought to identify the presence of amylin receptors on human fetal and murine microglia and determine whether Aβ activation of the inflammasome complex and subsequent release of cytokines is mediated through these receptors.

Methods: The presence of dimeric components of the amylin receptor (calcitonin receptor and receptor activity modifying protein 3) were ...


Development And Validation Of Triticum Phytobiological Method As An Alternative Procedure For Investigating In Vivo Acute Toxicity On Mice, Emil Ştefănescu, Aurelia N. Cristea, Cornel Chiriță, Octavian Olaru, Adriana Anghel, Mihaela Dinu 2017 Carol Davila University, Department of Pharmacology and Clinical Pharmacy, Bucharest, Romania

Development And Validation Of Triticum Phytobiological Method As An Alternative Procedure For Investigating In Vivo Acute Toxicity On Mice, Emil Ştefănescu, Aurelia N. Cristea, Cornel Chiriță, Octavian Olaru, Adriana Anghel, Mihaela Dinu

Journal of Mind and Medical Sciences

The goal of this study was to validate an alternative method for determining in vivo acute toxicity using vegetal material instead of laboratory animals, starting from the phytobiological method known also as the Triticum technique. We set out to demonstrate that vegetal cells have similar sensitivity to some toxic agents as animal cells, in which case a statistical correlation could be established. A series of new compounds synthesized by the Romanian National Institute for Chemical Pharmaceutical Research and Development as potential β3 adrenergic receptors agonists were tested for their acute toxicity using classic animal exposure models, before investigating possible anti-diabetic ...


Experimental Pharmacological Research Regarding Some Newly Synthesized Benzamides On Central Nervous System Functions, Cornel Chiriță, Emil Ștefănescu, Cristina D. Marineci, Simona Negreș, Diana C. Nuță 2017 Carol Davila University, Department of Pharmacology and Clinical Pharmacy, Bucharest, Romania

Experimental Pharmacological Research Regarding Some Newly Synthesized Benzamides On Central Nervous System Functions, Cornel Chiriță, Emil Ștefănescu, Cristina D. Marineci, Simona Negreș, Diana C. Nuță

Journal of Mind and Medical Sciences

Three newly synthesized benzamides by the Department of Pharmaceutical Chemistry of the Faculty of pharmacy from the University of Medicine and Pharmacy „Carol Davila” Bucharest were tested in order to determine whether these new molecules have similar effects on the central nervous system as those already in therapeutic use belonging to the same chemical group, such as tiapride (neuroleptic) or lidocaine (local anaesthetic). Tests were carried out on NMRI mice which were given new compounds, conventionally named I5C, I14C, and II5C in a dose of 1/20 of the lethal dose 50% (LD50), as previously determined. They received this treatment ...


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