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A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard 2014 East Tennessee State University

A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard

Undergraduate Honors Theses

In this study, three different chromatographic column chemistries (C18, Pentafluorophenyl (PFP), Hydrophilic Interaction Chromatography (HILIC)) were compared under optimal conditions to determine which stationary performed best in the separation and detection of a mixture of opioids using LC-MS. Furthermore, these stationary phases were examined in three different column technologies – traditional silica, porous shell, and porous polymer (PRP). The PRP column had the best peak shape for all 13 opioids and dominated for later-eluting compounds. In terms of column reproducibility, the Hamilton C18 column had the lowest %RSD values. The Kinetex HILIC produced the most theoretical plates and best resolution for ...


Examining Why The Canadian Federal Government Placed An Orphan Drug Strategy On Their Decision Agenda Now, Mark Gary Embrett 2014 McMaster University

Examining Why The Canadian Federal Government Placed An Orphan Drug Strategy On Their Decision Agenda Now, Mark Gary Embrett

Health Reform Observer - Observatoire des Réformes de Santé

The Ministry of Health’s announcement of a National Orphan Drug Framework on 3 October 2012 was the first federal public acknowledgement of orphan drugs since the 1997 Drugs Directorate (DD) policy statement. The reform primarily announced an Orphan Drug Policy for Canada. This paper explains why the government decided to make this announcement now. Media and Parliamentary documents were analyzed for their use of symbols, numbers, and language in causal stories told by political actors. The initial story was that Canada’s population was too small and the cost too high for an orphan drug policy. Over the next ...


Outcomes From Stanford Geriatric Education Center Faculty Development Program In Ethnogeriatrics’ First Cohort: Infusing Ethnogeriatric Content Into Health Professions Curricula, Sally Ellis Fletcher, Chanel Agness, Penelope Moore, Kisha O'Neal Gant, Thuan Ong, Karen Anne Wolf, Dolores Gallagher-Thompson, Nancy Hikoyeda 2014 Journal of Interprofessional Healthcare

Outcomes From Stanford Geriatric Education Center Faculty Development Program In Ethnogeriatrics’ First Cohort: Infusing Ethnogeriatric Content Into Health Professions Curricula, Sally Ellis Fletcher, Chanel Agness, Penelope Moore, Kisha O'Neal Gant, Thuan Ong, Karen Anne Wolf, Dolores Gallagher-Thompson, Nancy Hikoyeda

Journal of Interprofessional Healthcare

The Stanford Geriatric Education Center’s Faculty Development Program in Ethnogeriatrics (SGEC- FDPE) was funded by a USDHHS, Bureau of Health Professions GEC grant (No. UB4HP19049). The intensive 12-month 160-Hour SGEC-FDPE provides an innovative hybrid experience. The program focuses on ethnogeriatric teaching strategies, curriculum development, and addressing the needs of diverse older adults. The inaugural interprofessional cohort of six trainees from four disciplines: medicine, nursing, pharmacy, and social work were mentored by SGEC faculty during the development of capstone projects that incorporate ethnogeriatric principles and tools for health professions curricula, continuing education, and patient care strategies.

Innovations and specific SGEC ...


Interprofessional Education: Focus On Health Literacy, Kacie B. Monson, Anastasia Roberts 2014 Journal of Interprofessional Healthcare

Interprofessional Education: Focus On Health Literacy, Kacie B. Monson, Anastasia Roberts

Journal of Interprofessional Healthcare

Background: Interdisciplinary collaboration among healthcare providers is essential to promote wellness and disease prevention. To develop student competency in this area, St. Louis College of Pharmacy and Goldfarb School of Nursing created an interprofessional course entitled “Indigent Populations: Focus on Health Literacy”.

Objectives: This course develops competence in patient-centered care, care coordination, and healthcare system navigation, all in the context of service to indigent populations. The course general ability outcomes are the promotion of civic engagement, encouragement of interprofessional collaboration, and improvement in oral and written communication skills.

Design: In interprofessional teams, students develop a preventative health lecture, which is ...


Gold(Iii)-Dithiocarbamato Peptidomimetics In The Forefront Of The Targeted Anticancer Therapy: Preclinical Studies Against Human Breast Neoplasia, Chiara Nardon, Sara M. Schmitt, Huanjie Yang, Jian Zuo, Delores Fregona, Q. Ping Dou 2014 Wayne State University

Gold(Iii)-Dithiocarbamato Peptidomimetics In The Forefront Of The Targeted Anticancer Therapy: Preclinical Studies Against Human Breast Neoplasia, Chiara Nardon, Sara M. Schmitt, Huanjie Yang, Jian Zuo, Delores Fregona, Q. Ping Dou

Oncology Faculty Publications

Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is limited by many severe side-effects. In order to both improve the chemotherapeutic index and broaden the therapeutic spectrum of current drugs, our most recent anti-neoplastic agents, Au(III) complexes, were designed as carrier-mediated delivery systems exploiting peptide transporters, which are up-regulated in some cancers. Among all, we focused on two compounds and tested them on human MDA-MB-231 (resistant to cisplatin) breast cancer cell cultures and xenografts, discovering the proteasome as a major target both in vitro and in vivo ...


Surface-Modified Micellar Formulations Of Curcumin Co-Loaded With Chemotherapeutic Agents For Enhanced Anti-Cancer Effect, Abraham H. Abouzeid 2014 Northeastern University

Surface-Modified Micellar Formulations Of Curcumin Co-Loaded With Chemotherapeutic Agents For Enhanced Anti-Cancer Effect, Abraham H. Abouzeid

Pharmaceutical Science Dissertations

Even though there have been significant improvements in the detection and treatment of early stage cancers, the ability to successfully treat advanced forms of the disease remains a challenge due to the acquired resistance to chemotherapy. Numerous studies indicate that the nuclear factor-kappa B (NF-КB)-induced cascade of gene expression as being a key factor in producing such chemo-resistant tumor phenotypes. Here, we investigated the efficacy of curcumin (CUR), a potent NF-kB inhibitor, co-loaded with either paclitaxel (PCL) or doxorubicin (DOX) in mixed micelles, made of PEG-PE and vitamin E, against a range of cancer cell types.

First, the combination ...


In Vitro Evaluations Of Bisphosphonate Therapy In Refractory Cancer By Targeting Tumor-Associated Macrophages, Aatman Satish Doshi 2014 Northeastern University

In Vitro Evaluations Of Bisphosphonate Therapy In Refractory Cancer By Targeting Tumor-Associated Macrophages, Aatman Satish Doshi

Pharmaceutical Science Master's Theses

The main aim of this MS thesis project was to develop a targeted drug delivery system which is capable of targeting tumor-associated macrophages (TAMs). Alendronate sodium trihydrate which is a bisphosphonate drug which is originally a drug used for osteoporosis, was repurposed for its ability to kill TAMs. Non-targeted liposomal formulation was developed using a film hydration method, which was able to encapsulate alendronate sodium trihydrate. Lyp-1 was selected as a targeting peptide which has a capability to bind to p32/hyaluronic acid binding receptor/gC1qR/p33 expressed highly on tumor cells and TAM's. Lyp-1-modified liposomes were synthesized to ...


Multi-Component Microparticulate/Nanoparticulate Dry Powder Inhalation Aerosols For Targeted Pulmonary Delivery, Xiaojian Li 2014 University of Kentucky

Multi-Component Microparticulate/Nanoparticulate Dry Powder Inhalation Aerosols For Targeted Pulmonary Delivery, Xiaojian Li

Theses and Dissertations--Pharmacy

The aim of the work was to design, manufacture, and characterize targeted multi-component dry powder aerosols of (non-destructive) mucolytic agent (mannitol), antimicrobial drug (tobramycin or azithromycin), and lung surfactant mimic phospholipids (DPPC:DPPG=4:1 in molar ratio). The targeted dry powder for inhalation formulation for deep lung delivery with a built-in rationale of specifically interfering several disease factors of chronic infection diseases in deep lungs such as cystic fibrosis, pneumonia, chronic bronchitis, and etc. The dry powder aerosols consisting of selected chemical agents in one single formulation was generated by using spray drying from organic solution.

The physicochemical properties ...


Evaluation Of The Appropriate Weaning Of Neonatal Morphine Solution (Nms) In The Treatment Of Neonatal Abstinence Syndrome (Nas) And Its Effect On Length Of Stay (Los), Nicole Hollinger, PharmD Candidate, Christopher Hvisdas, PharmD Candidate, Maria Samohod, MD Candidate, Tara E. DeCerbo, PharmD, Janet Larson, MD, Kristin McKenna, MD, Lindsey Roke, PharmD 2013 Thomas Jefferson University

Evaluation Of The Appropriate Weaning Of Neonatal Morphine Solution (Nms) In The Treatment Of Neonatal Abstinence Syndrome (Nas) And Its Effect On Length Of Stay (Los), Nicole Hollinger, Pharmd Candidate, Christopher Hvisdas, Pharmd Candidate, Maria Samohod, Md Candidate, Tara E. Decerbo, Pharmd, Janet Larson, Md, Kristin Mckenna, Md, Lindsey Roke, Pharmd

Pharmacy, Presentations and Grand Rounds

Purpose: Neonates suffering from NAS receive NMS to treat withdrawal symptoms associated with this disease. Frequent NMS dosing and close monitoring are required to ensure adequate symptom control and prevent adverse events. Maximum dose achieved, titration, severity of disease, and variance in in-utero exposure to addictive drugs all contribute to length of stay. The primary objective of this drug utilization evaluation is to assess adherence to current institutional guidelines for titrating neonates and infants off NMS and to identify opportunities for improvement to potentially decrease length of stay in this population.

Methods: A retrospective chart review of neonates and infants ...


Pharmacist Empathy In Smoking Cessation Counseling, Caleb Lyman, Megan McNicol, Maria Miller, Yevgeniy Solokha, Kelly J. Wright, Aleda M.H. Chen 2013 Cedarville University

Pharmacist Empathy In Smoking Cessation Counseling, Caleb Lyman, Megan Mcnicol, Maria Miller, Yevgeniy Solokha, Kelly J. Wright, Aleda M.H. Chen

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Cigarette smoking and nicotine addiction are prevalent in today’s society. Approximately 19% of American adults (43.8 million people) smoke cigarettes. Smoking is associated with health risks such as Chronic Obstructive Pulmonary Disease (COPD), infertility, low birth weight, respiratory symptoms, heart disease, and lung cancer and is responsible for roughly $96 billion in health care costs. Provider empathy has been proven effective in other treatments like cold and cancer; however, its effectiveness in smoking cessation has not yet been studied. Empathy is defined in two realms: cognitive and affective. In the cognitive domain, individuals have the ability to understand ...


Effectiveness Of Clinical Scenarios In Improving Student Interprofessional Skills And Attitudes, Ashley Peterson, Mike Pelyhes, Laura Cummings, Phillip L. Thornton, Zachary N. Jenkins 2013 Cedarville University

Effectiveness Of Clinical Scenarios In Improving Student Interprofessional Skills And Attitudes, Ashley Peterson, Mike Pelyhes, Laura Cummings, Phillip L. Thornton, Zachary N. Jenkins

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Background: “Interprofessional education (IPE) is defined as the process by which individuals from two or more health professions learn with, from, and about each other across the spectrum of their education to improve collaboration, practice, and the quality of health care.” [1] Interprofessional Education has recently gained interest as an important aspect of training in healthcare professions, attracting the attention and support of several key pharmacy organizations. Various models of IPE have been implemented to facilitate collaboration among medical, nursing, pharmacy, and social work students and professionals. One model found to be particularly effective among pharmacy students is a mock ...


The Pivotal Role Of The Pharmacist In A Primary Care Office, Julie Cummings, Olumami O. Amaye, McKenzie Shenk, Cara Toms, Nathanael Smith, Thaddeus T. Franz, Tracy R. Frame 2013 Cedarville University

The Pivotal Role Of The Pharmacist In A Primary Care Office, Julie Cummings, Olumami O. Amaye, Mckenzie Shenk, Cara Toms, Nathanael Smith, Thaddeus T. Franz, Tracy R. Frame

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Abstract

The profession of pharmacy has evolved from a dispensing role to an interdisciplinary clinical role in patient care. One area of patient care expertise is Medication Therapy Management (MTM), which includes services such as pharmacotherapy, medication therapy reviews, disease management, immunizations and other clinical services. In various studies, pharmacists conducting MTM have shown improved patient outcomes in community pharmacy and hospital settings. Amidst the valuable services all healthcare professionals are providing, increasing medical costs and consequences have become overwhelming, leading to negative patient outcomes. A lack of primary care physicians (PCPs) may contribute to these distressing facts. Gaps in ...


The Impact Of Free Health Screenings At Community Pharmacies On Diabetes, Anna M. Smith, Nicholas C. Daniels, Jessica E. Amtower, Jeniffer George, Jacques N. Allou, Jeb Ballentine, Emily M. Laswell 2013 Cedarville University

The Impact Of Free Health Screenings At Community Pharmacies On Diabetes, Anna M. Smith, Nicholas C. Daniels, Jessica E. Amtower, Jeniffer George, Jacques N. Allou, Jeb Ballentine, Emily M. Laswell

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Title: The Impact of Free Health Screenings at Community Pharmacies on Diabetes

Authors: Jacques Allou, Jessica Amtower, Nicholas Daniels, Jeniffer George, Anna Smith, Jeb Ballentine, Pharm.D., and Emily Laswell, Pharm.D.

Background: Health screenings can be beneficial when looking to detect diseases early on, thus making treatment easier. Free health screenings are typically performed in the community pharmacy setting. This makes it convenient because it is easily accessible and there is no appointment required. Diabetes is currently one of the most significant health issues faced today, with an estimated 7 million Americans going undiagnosed. Health screenings in community pharmacies ...


Access To Healthy Foods Across America, Aaron D. Le Poire, Ginger Cameron, Heather Evankow, Andrea Bashore, Jacob Farran, Jesse Hickey 2013 Cedarville University

Access To Healthy Foods Across America, Aaron D. Le Poire, Ginger Cameron, Heather Evankow, Andrea Bashore, Jacob Farran, Jesse Hickey

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Research indicates that individuals who have access to healthy food tend to eat healthier. Food environments that do not have access to healthy food have been shown to be a leading cause of obesity in the United States. Major health consequences of obesity include cardiovascular disease, type 2 diabetes, hypertension, stroke, high cholesterol, gallbladder disease, osteoarthritis, and some cancers. The availability of healthy foods can be determined by median household income, with income levels being shown to affect access to healthy foods in local areas. However, no study has shown if this phenomenon is prevalent across the United States. Our ...


Evaluating The Bioavailability Of Carbamazepine Using A Novel Snedds Formulation, Elisha R. Injeti, Gina M. Mattes, Rebecca A. Kyper, Derrick L. Chapman, Jinwon Byun, Zachary A. Wallace 2013 Cedarville University

Evaluating The Bioavailability Of Carbamazepine Using A Novel Snedds Formulation, Elisha R. Injeti, Gina M. Mattes, Rebecca A. Kyper, Derrick L. Chapman, Jinwon Byun, Zachary A. Wallace

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Central to the mechanism of how drugs work are the concepts of solubility and bioavailability. Drugs enter the body via absorption into the bloodstream, arrive at the target location, and bind to receptors to cause an effect. Drugs need to be soluble enough to pass through the cell membrane to enter and exit the bloodstream. Higher solubility generally correlates to higher bioavailability. Additionally, the smaller the particle size, the easier the drug will pass through the membrane into the blood plasma. Researchers have designed a system to categorize solubility class: Class I being high permeability and high solubility, Class II ...


Natural Products As Therapeutic Agents In Cancer Treatment, Eric Huseman, Lauren P. Williams, Brittany Santee, Trevor Stump, Chelsae Ward, Rachel Kunze, Dr. Denise Simpson, Dr. Samson Amos 2013 Cedarville University

Natural Products As Therapeutic Agents In Cancer Treatment, Eric Huseman, Lauren P. Williams, Brittany Santee, Trevor Stump, Chelsae Ward, Rachel Kunze, Dr. Denise Simpson, Dr. Samson Amos

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Cancer accounts for 25% of deaths in the United States, and brain tumors greatly contribute to this percentage. However, relative to other types of cancers, brain tumors prove difficult to treat because they are heterogeneous, highly proliferative, highly invasive, and resistant to the traditional cancer treatments of chemotherapy and radiotherapy. Past studies have shown that flavonoids and curcuminoids, two classes of compounds derived from natural sources, are effective in inhibiting the development and metastasis of breast and lung cancer cells. Research has also indicated that these compounds have potential for treating brain tumors.

The purpose of this research is to ...


Efficacy Of Marketing Strategy For Reach Vitamins, Jessica Davis, Jordan Long, Megan Buck, Paul Bicknell, Melody Hartzler 2013 Cedarville University

Efficacy Of Marketing Strategy For Reach Vitamins, Jessica Davis, Jordan Long, Megan Buck, Paul Bicknell, Melody Hartzler

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

According to the 2009 Global Report, Vitamin A supplementation in children reduces the death rate by 23% in populations at risk of deficiency. REACH Vitamins is a for-profit business that provides a one-year supply of vitamin A to children in underprivileged countries for each bottle of vitamins A, B, C, D, or the multivitamin purchased. The primary objective of this exploratory, qualitative study is to determine if there is a more appropriate marketing strategy for REACH Vitamins compared to the current marketing strategy used. The secondary objective is to determine if REACH Vitamins’ charity motivates consumers to purchase their products ...


Characterization Of Prophylactic Antiemetic Regimens In Pediatric Patients Receiving Moderately And Highly Emetogenic Chemotherapy, Jessica Degiacomo PharmD, Kristin M. Held PharmD, BCOP 2013 Lehigh Valley Health Network

Characterization Of Prophylactic Antiemetic Regimens In Pediatric Patients Receiving Moderately And Highly Emetogenic Chemotherapy, Jessica Degiacomo Pharmd, Kristin M. Held Pharmd, Bcop

Department of Pharmacy

No abstract provided.


Anticancer Properties Of Distinct Antimalarial Drug Classes, Rob Hooft van Huijsduijnen, R. Kiplin Guy, Kelly Chibale, Richard K. Haynes, Ingmar Peitz, Gerhard Kelter, Margaret A. Phillips, Jonathan L. Vennerstrom, Yongyuth Yuthavong, Timothy N. C. Wells 2013 University of Nebraska Medical Center

Anticancer Properties Of Distinct Antimalarial Drug Classes, Rob Hooft Van Huijsduijnen, R. Kiplin Guy, Kelly Chibale, Richard K. Haynes, Ingmar Peitz, Gerhard Kelter, Margaret A. Phillips, Jonathan L. Vennerstrom, Yongyuth Yuthavong, Timothy N. C. Wells

Journal Articles: Pharmaceutical Sciences

We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductase) inhibitors effected potent inhibition of proliferation with IC50s in the nM- low µM range, whereas a DHODH (dihydroorotate dehydrogenase) and a putative kinase inhibitor displayed no activity. Furthermore, significant synergies were identified with erlotinib, imatinib, cisplatin, dasatinib and vincristine. Cluster analysis of the antimalarials based on their differential inhibition of the various cancer lines clearly segregated the synthetic peroxides OZ277 and OZ439 from the artemisinin ...


Binding, Transcytosis And Biodistribution Of Anti-Pecam-1 Iron Oxide Nanoparticles For Brain-Targeted Delivery, Mo Dan, David B. Cochran, Robert A. Yokel, Thomas D. Dziubla 2013 University of Kentucky

Binding, Transcytosis And Biodistribution Of Anti-Pecam-1 Iron Oxide Nanoparticles For Brain-Targeted Delivery, Mo Dan, David B. Cochran, Robert A. Yokel, Thomas D. Dziubla

Pharmaceutical Sciences Faculty Publications

OBJECTIVE: Characterize the flux of platelet-endothelial cell adhesion molecule (PECAM-1) antibody-coated superparamagnetic iron oxide nanoparticles (IONPs) across the blood-brain barrier (BBB) and its biodistribution in vitro and in vivo.

METHODS: Anti-PECAM-1 IONPs and IgG IONPs were prepared and characterized in house. The binding affinity of these nanoparticles was investigated using human cortical microvascular endothelial cells (hCMEC/D3). Flux assays were performed using a hCMEC/D3 BBB model. To test their immunospecificity index and biodistribution, nanoparticles were given to Sprague Dawley rats by intra-carotid infusion. The capillary depletion method was used to elucidate their distribution between the BBB and brain parenchyma ...


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