Molecular Overlap In The Regulation Of Sk Channels By Small Molecules And Phosphoinositides, 2015 Chapman University
Molecular Overlap In The Regulation Of Sk Channels By Small Molecules And Phosphoinositides, Miao Zhang, Xuan-Yu Meng, Ji-Fang Zhang, Meng Cui, Diomedes E. Logothetis
Pharmacy Faculty Articles and Research
Phosphatidylinositol 4,5-bisphosphate (PIP2) directly interacts with the small-conductance Ca2+-activated K+ 2-a (SK2-a) channel/calmodulin complex, serving as a critical element in the regulation of channel activity. We report that changes of protein conformation in close proximity to the PIP2 binding site induced by a small-molecule SK channel modulator, NS309, can effectively enhance the interaction between the protein and PIP2 to potentiate channel activity. This novel modulation of PIP2 sensitivity by small-molecule drugs is likely not to be limited in its application to SK channels, representing an intriguing strategy to develop drugs controlling the activity of the large number ...
The Role Of Community Pharmacy-Based Vaccination In The Usa: Current Practice And Future Directions, 2015 Chapman University
The Role Of Community Pharmacy-Based Vaccination In The Usa: Current Practice And Future Directions, Jeff Goad, Albert Bach
Community pharmacy-based provision of immunizations in the USA has become commonplace in the last few decades, with success in increasing rates of immunizations. Community pharmacy-based vaccination services are provided by pharmacists educated in the practice of immunization delivery and provide a convenient and accessible option for receiving immunizations. The pharmacist’s role in immunization practice has been described as serving in the roles of educator, facilitator, and immunizer. With a majority of pharmacist-provided vaccinations occurring in the community pharmacy setting, there are many examples of community pharmacists serving in these immunization roles with successful outcomes. Different community pharmacies employ a ...
Intractable Delay And The Need To Amend The Petition Provisions Of The Fdca, 2015 Indiana University Robert H. McKinney School of Law
Intractable Delay And The Need To Amend The Petition Provisions Of The Fdca, Diana R. H. Winters
Indiana Law Journal
Private party oversight has proven to be ineffective at countering inaction by the Food and Drug Administration (FDA). Inaction when regulation is warranted can put the public at continued and increasing risk of harm, but the failure of private enforcement to compel action reverberates beyond this harm to the interests of individuals. It also diminishes the transparency of agency decision making, lessens the opportunity for public participation, and reduces the interaction between the institutions that oversee agencies. Moreover, the benefits afforded to the administrative process by judicial review are weakened.
This Article analyzes two examples of FDA inertia and compares ...
Higher Hepatic Mir-29 Expression In Undernourished Male Rats During The Postnatal Period Targets The Long-Term Repression Of Insulin-Like Growth Factor 1, Gurjeev Sohi, Andrew Revesz, Julie Ramkumar, Daniel B. Hardy
Physiology and Pharmacology Publications
A nutritional mismatch in postnatal life of low birth weight offspring increases the risk of developing the metabolic syndrome. Moreover, this is associated with decreased hepatic insulin-like growth factor 1 (Igf1) expression, leading to impaired growth and metabolism. Previously we have demonstrated that the timing of nutritional restoration in perinatal life can differentially programhepatic gene expression. While micro RNAs also play an important role in silencing gene expression, to date, the impact of a nutritional mismatch in neonatal life on their long-term expression has not been evaluated. Given the complementarity of miR-29 to the 3i-UTR of Igf1, we examined how ...
Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors, 2015 University of Maryland-Baltimore
Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors, Bruno Ramos-Molina, Adam N. Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg
Pharmacy Faculty Articles and Research
Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity in vitro. In agreement, HIV-1 TAT47-57 reduced HT1080 cell migration, thought to be mediated by proprotein convertases, by 25%. In addition, cyclic polyarginine peptides containing hydrophobic moieties which have been previously used as transfection reagents also exhibited potent furin inhibition in vitro ...
Awareness And Utilization Of The Ohio Automated Rx Reporting System By Physician Assistants, 2015 University of New England
Awareness And Utilization Of The Ohio Automated Rx Reporting System By Physician Assistants, Julia Cathleen Rose
All Theses And Dissertations
Chronic pain has become a public health epidemic. As pain complaints increase, so does the potential for drug abuse/misuse. Prescription drug monitoring programs (PDMPs) are active in 49 of the 50 states to assist providers in recognizing drug abuse/misuse. There is no clear standardization of who utilizes the PDMP and how. Little is still known about the ways PDMP results are incorporated into clinical decision making, what barriers exist, and how providers may or may not alter their prescribing plans based on the results. Laws surrounding prescribing practices and use of the Ohio Automated Rx Reporting System (OARRS ...
Mala Lā’Au Lapa’Au: Preserving The Hawaiian ‘Āina And Mo’Omehue, 2015 University of Rhode Island
Mala Lā’Au Lapa’Au: Preserving The Hawaiian ‘Āina And Mo’Omehue, Sandra Fogg
Senior Honors Projects
The study of medicinal plants in the western world tends to focus on the isolation and elucidation of natural products that have bioactive characteristics and potential for pharmaceutical formulation. However, the utilization of medicinal plants in cultures that still practice ancient medicine, such as Hawai’i and other Pacific Island nations, involves the use of whole plant parts in conjunction with spiritual rituals to heal illnesses and ailments. In order to gather a different perspective of the use of plants in medicine, a diverse investigation of “Lā’au Lapa’au,” or the Hawaiian art of healing through the use of ...
Milking The Information: Resources On Herbal Lactation Aids, 2015 Philadelphia College of Osteopathic Medicine
Milking The Information: Resources On Herbal Lactation Aids, Erica Rosalle
PCOM Scholarly Papers
This article provides information for the layperson on herbs commonly used as galactagogues (lactation aids), their effectiveness, and risks according to existing scientific literature. In addition, resources for further research on herbal lactation aids are listed.
Compulsory Licenses: Damaging Firm Value In The Short Run?, 2015 Bates College
Compulsory Licenses: Damaging Firm Value In The Short Run?, Daniel E. Mansuri Mr.
While very few individuals question the validity and necessity of the patent system, the temporary monopolies imposed by patents necessarily reduce access to medication. This becomes especially problematic when dealing with issues of public ordre, such as the aids crisis in the last 30 years. Compulsory licensing, or the power for a government to void a patent and allow a non-patent holder to produce a patented good, aims to remedy this problem. Governments have the ability to issue these in times of epidemics, or other issues of rampant illness. However, even though these licenses are completely legal, pharmaceutical companies meet ...
Analyzation Of Metabolic Reprogramming In Drug-Resistant Mcf-7 Cells, 2015 Keck Graduate Institute
Analyzation Of Metabolic Reprogramming In Drug-Resistant Mcf-7 Cells, Derick Han, Ho Leung, Andrew Vo
Student Research Day Abstracts and Posters
The Warburg effect states that cancer cells mainly receive their energy from anaerobic glycolysis. Thus, mitochondria play a different role in the metabolism of cancer cells as opposed to normal, healthy cells. In chemotherapy, there is always a chance of the cancer regressing. Making drug-resistant cancer cells to analyze their metabolism may change how cancer is treated. This study aimed to create drug-resistant MCF-7 cell lines with doxorubicin in order to determine the metabolic changes that have occurred in the process of becoming resistant to drug treatments.
Clinical Applications Of A Combination Chemotherapy Using 8-Chloro Camp And 8-Chloro Adenosine, 2015 Chapman University
Clinical Applications Of A Combination Chemotherapy Using 8-Chloro Camp And 8-Chloro Adenosine, Erik Munoz, Andrea Saich, Andrew Cox, Yu-An Peter Chang
Student Research Day Abstracts and Posters
Dr. Cho-Chung from the NIH first thought to use halogenated cAMP derivatives as competitive inhibitors of cAMP to slow down cancer cell mitosis. While the iodine and bromine substituted versions showed very little therapeutic actions, 8-Chloro cAMP has been shown to have strong anti-cancer effects. This has been shown in the phase II clinical trials this drug has undergone. However, these trials have had issues with solubility and toxicity. The drug is similar to vitamin C and is excreted quickly. Scientists tried to overcome this by using a peristaltic pump to give patients a continuous dosage, but this proved too ...
Argatroban For The Treatment Of Heparin-Induced Thrombocytopenia In End Stage Renal Disease And Acute Kidney Injury, 2015 University of Tennessee Health Science Center
Argatroban For The Treatment Of Heparin-Induced Thrombocytopenia In End Stage Renal Disease And Acute Kidney Injury, Lindsey Elmore Pharmd, Bcps, Leslie A. Hamilton Pharm.D., Bcps
Tennessee Medicine E-Journal
Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, 2015 Virginia Commonwealth University
Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, Sneha Shah
G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways. The serotonin 5HT2A receptor (or 2AR) is one of the GPCRs coupled to Gq proteins, activating PLC and hydrolyzing PIP2. This hydrolysis causes a diffusion of bound PIP2 away from the channel binding site resulting in G protein-gated inwardly rectifying K+ channel (GIRK) inhibition and a downstream stimulation of Ca2+ release from endoplasmic reticulum stores. Previous experiments have demonstrated that the serotonin 5HTA receptor is a target of serotonergic psychedelic drugs, such as LSD, and partially mediates the action of many atypical antipsychotic ...
Periodontal Disease: Molecular Visualization Through Computer Modeling And 3d Printing, 2015 University of Rhode Island
Periodontal Disease: Molecular Visualization Through Computer Modeling And 3d Printing, Catherine Chatowsky
Senior Honors Projects
Periodontal disease is a common infection that damages gingival tissue and creates jawbone destruction that can lead to the loosening or loss of teeth. Hundreds of diverse bacterial species reside in the harsh environment of the oral cavity. The creation of plaque and biofilms serve to allow the bacteria to avoid immune-mediated destruction. This project analyzed periodontal disease pathogens using molecular printing 3D visualization. Two bacterial species (T. denticola and P. gingivalis) were chosen from the public resource: Research Collaboratory for Structural Bioinformatics: Protein Data Bank. T. denticola was a bacteria found to have a binding protein (FhbB) that structurally ...
The Effects Of Rhein And Thymoquinone On Obesity And Diabetes In Diet-Induced Obese Mice., 2015 University of Rhode ISland
The Effects Of Rhein And Thymoquinone On Obesity And Diabetes In Diet-Induced Obese Mice., Emily Martell
Senior Honors Projects
Natural product extracts and chemicals isolated from natural products (e.g. plants, berries, seeds) have been commonly used in various types of traditional medicines. In addition, some drugs on the market today have been derived from natural product sources. The purpose of our study was to evaluate two natural products, Rhein and Thymoquinone, for as potential anti-diabetic and anti–obesity agents. According to the Center for Disease Control (CDC), the number of people in the US diagnosed with diabetes has increase from 11.9 million people in the year 2000 to 20.8 million people in the year 2011. Rhein ...
An Information Privacy Examination Of The Practices Of Pharmaceutical Companies Regarding Use Of Information Collected Through Their Websites, Shonda Dellena Brown
Consumers have begun to take a more proactive approach to their healthcare by accessing pharmaceutical companies Websites to obtain health and drug information, support groups, rebates, coupons, as well as free drug trials. In exchange for these benefits, companies require consumers to voluntarily disclose information. However, research has shown that consumers continue to be concerned about how their information is managed, used, and distributed by companies, especially if accessed via the Web. To date, there has been limited empirical research to examine the actual online practices of companies when it comes to privacy, especially those of pharmaceutical companies. Using Delphi ...
Methylphenidate And Dexmethylphenidate Formulations In Children With Attention-Deficit/Hyperactivity Disorder, 2015 University of Connecticut School of Pharmacy
Methylphenidate And Dexmethylphenidate Formulations In Children With Attention-Deficit/Hyperactivity Disorder, David Sugrue
Honors Scholar Theses
Purpose: To review the current literature on the various extended-release methylphenidate stimulant preparations regarding safety and efficacy in children and adolescents with attention-deficit/hyperactivity disorder (ADHD).
Summary: The literature reviewed establishes the efficacy of the different long-acting methylphenidate stimulant formulations in treating children and adolescents with ADHD. Comparing and contrasting the different extended-release preparations allows for clinicians to help tailor ADHD treatments to individual patients. The extended release methylphenidate products provide the same efficacy as the immediate release formulations, but add the convenience of less frequent dosing. There are a few options for patients with difficulty swallowing tablets or capsules ...
Development And Testing Of An Occupational Therapy Intervention To Promote Medication Adherence, 2015 University of Wisconsin-Milwaukee
Development And Testing Of An Occupational Therapy Intervention To Promote Medication Adherence, Jaclyn K. Schwartz
Theses and Dissertations
Many persons with chronic health conditions fail to take their medications as prescribed, resulting in declines in health and function. Unfortunately, current interventions for medication nonadherence are not very effective. Medication adherence is a daily activity, which many occupational therapists believe would be responsive to occupational therapy intervention. Unfortunately, few resources support occupational therapists in this role. The purpose of this dissertation is to create the foundational work for occupational therapy medication adherence interventions. In this dissertation, I accomplish five objectives. First, I identify the role of occupational therapy practitioners in the medication adherence field. Second, I create a manualized ...
Interactive Web-Based Learning Modules Prior To General Medicine Advanced Pharmacy Practice Experiences, Alex N. Isaacs, Alison M. Walton, Sarah A. Nisly
Scholarship and Professional Work – COPHS
Objective. To implement and evaluate interactive web-based learning modules prior to advanced pharmacy practice experiences (APPEs) on inpatient general medicine.
Design. Three clinical web-based learning modules were developed for use prior to APPEs in 4 health care systems. The aim of the interactive modules was to strengthen baseline clinical knowledge before the APPE to enable the application of learned material through the delivery of patient care.
Assessment. For the primary endpoint, postassessment scores increased overall and for each individual module compared to preassessment scores. Postassessment scores were similar among the health care systems. The survey demonstrated positive student perceptions of ...
Improving Healthcare Outcomes Through An Interdisciplinary Effort Of Social Work And Pharmacy In A “Village” Model Setting, 2015 Ohio State University - Main Campus
Improving Healthcare Outcomes Through An Interdisciplinary Effort Of Social Work And Pharmacy In A “Village” Model Setting, Elizabeth Hipp, Lauren Post
Ohio Association of Gerontology and Education Conference
OAGE is an association of educators, researchers, professionals, and students in Ohio dedicated to gerontological education, research and practice. The organization promotes gerontological education, supports Ohio's aging network as a resource for research and practice, and provides professional development for students, faculty and professionals.
OAGE is committed to maintaining close working relationships with the Ohio Department of Aging, the Ohio Area Agencies on Aging, Ohio's post secondary institutions, and all professional organizations and individuals in the aging network.