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Posaconazole Tablet Pharmacokinetics: Lack Of Effect Of Concomitant Medications Altering Gastric Ph And Gastric Motility In Healthy Subjects., Walter K. Kraft, Peter S. Chang, Marlou L P S van Iersel, Hetty Waskin, Gopal Krishna, Wendy M Kersemaekers 2014 Thomas Jefferson University

Posaconazole Tablet Pharmacokinetics: Lack Of Effect Of Concomitant Medications Altering Gastric Ph And Gastric Motility In Healthy Subjects., Walter K. Kraft, Peter S. Chang, Marlou L P S Van Iersel, Hetty Waskin, Gopal Krishna, Wendy M Kersemaekers

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Posaconazole oral suspension is an extended-spectrum triazole that should be taken with food to maximize absorption. A new posaconazole tablet formulation has demonstrated improved bioavailability over the oral suspension in healthy adults in a fasting state. This study evaluated the effects of concomitant medications altering gastric pH (antacid, ranitidine, and esomeprazole) and gastric motility (metoclopramide) on the pharmacokinetics of posaconazole tablets. This was a prospective open-label 5-way crossover study in 20 healthy volunteers. In each treatment period, a single 400-mg dose (4 100-mg tablets) of posaconazole was administered alone or with 20 ml antacid (2 g of aluminum hydroxide and ...


An Interprofessional Falls Assessment Clinic Model To Develop Collaborative Team Skills Among Health Professional Students, Tracey Vause-Earland, MS, OTR/L, Leigh Ann Hewston, PT, MEd, Cecilia Borden, EdD, MSN, Brooke Salzman, MD, Emily Hajjar, PharmD, Ellen Furman, MSW, Christine Hsieh, MD, Susan Parks, MD 2014 Thomas Jefferson University

An Interprofessional Falls Assessment Clinic Model To Develop Collaborative Team Skills Among Health Professional Students, Tracey Vause-Earland, Ms, Otr/L, Leigh Ann Hewston, Pt, Med, Cecilia Borden, Edd, Msn, Brooke Salzman, Md, Emily Hajjar, Pharmd, Ellen Furman, Msw, Christine Hsieh, Md, Susan Parks, Md

Department of Occupational Therapy, Presentations

BACKGROUND

  • Older adults are at increased risk for falls and fall related injuries, leading to loss of independence, disability, and increased mortality.
  • Preventing injury and falls is a national Healthy People 2010 objective. However, physicians and other health professionals frequently fail to incorporate known evidence into usual care. Screening for falls is not consistently performed as an essential assessment in older adults by primary care providers.
  • Multidisciplinary assessment can be an important component in preventing falls in community dwelling adults.
  • In new practice models, such as the Chronic Care Model, there is an emphasis on interdisciplinary collaboration, however health professions ...


Development Of A Partnership For International Rural Advanced Pharmacy Practice Experiences, Emily K. Flores, Linsey A. Courtney 2014 East Tennessee State University

Development Of A Partnership For International Rural Advanced Pharmacy Practice Experiences, Emily K. Flores, Linsey A. Courtney

International Journal of Health Sciences Education

Objective. To design a faculty-guided international elective Advanced Pharmacy Practice Expereince (APPE) in partnership with a medical relief organization. To expose students to pharmacy-related opportunities in non-traditional settings focused on an indigent population, while obtaining a global perspective on healthcare.

Methods. The College of Pharmacy partnered with an international medical relief organization utilizing their resources for trip planning and in-country logistics to provide a framework for a pharmacy student rotation. The international trip is a portion of the calendar month rotation, while the balance is faculty-guided discussion groups, involvement in formulary planning, developing educational materials, and local medical relief work ...


Counterfeiting: A Challenge To Forensic Science, The Criminal Justice System, And Its Impact On Pharmaceutical Innovation, Pauline Elizabeth Leary 2014 The Graduate Center, CUNY

Counterfeiting: A Challenge To Forensic Science, The Criminal Justice System, And Its Impact On Pharmaceutical Innovation, Pauline Elizabeth Leary

Dissertations and Theses, 2014-Present

Counterfeit drugs threaten public health and present unique and complex challenges to the criminal justice system and the field of forensic science. Theft of intellectual property in the pharmaceutical industry has caused sickness and death, and it is necessary that the perpetrators of these crimes are brought to justice. In some cases, threats to health and safety are short term; in others they are long term. This research describes these threats in detail.

The problem is complex, and there are many important factors that need to be considered to successfully address the problem. Public-health challenges, drug-development challenges, legal challenges, issues ...


Einstein's Medication Reach Program Enhances Patient Care, Deborah Hauser RPh, MHA 2014 Thomas Jefferson University

Einstein's Medication Reach Program Enhances Patient Care, Deborah Hauser Rph, Mha

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.


Chemical Profiling And Biological Activity Of Two Tunicate-Associated Marine Bacteria, Lyubina Yankova 2014 University of Connecticut

Chemical Profiling And Biological Activity Of Two Tunicate-Associated Marine Bacteria, Lyubina Yankova

Honors Scholar Theses

Marine natural products have recently been an increasingly abundant source of novel antibiotics. Given that there is an increasing resistance to current drug therapies, finding new sources such as marine natural products is essential. Tunicate-associated marine bacteria can be a significant source of antibacterial compounds. Two tunicates of the species Eudistoma were collected from Portobelo National Park on the Salmedina Reef of Panama in the Caribbean Sea. Bacteria associated with the tunicate were isolated, cultured, extracted, and fractionated. Fractions were tested against an array of clinically relevant bacterial pathogens in the BioMAP assay. Two fractions MB0086E and MB0088E demonstrated activity ...


A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard 2014 East Tennessee State University

A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard

Undergraduate Honors Theses

In this study, three different chromatographic column chemistries (C18, Pentafluorophenyl (PFP), Hydrophilic Interaction Chromatography (HILIC)) were compared under optimal conditions to determine which stationary performed best in the separation and detection of a mixture of opioids using LC-MS. Furthermore, these stationary phases were examined in three different column technologies – traditional silica, porous shell, and porous polymer (PRP). The PRP column had the best peak shape for all 13 opioids and dominated for later-eluting compounds. In terms of column reproducibility, the Hamilton C18 column had the lowest %RSD values. The Kinetex HILIC produced the most theoretical plates and best resolution for ...


Lrh1 As A Driving Factor For Cancer Development, Alissa M. Margraf 2014 University of Rhode Island

Lrh1 As A Driving Factor For Cancer Development, Alissa M. Margraf

Senior Honors Projects

LRH1 as a driving factor for cancer development

Alissa Margraf, Qi Tang, Qiushi Lin, Xiaoqun Dong

Department of Biomedical and Pharmaceutical Science, College of Pharmacy, The University of Rhode Island, Pharmacy Building, 7 Greenhouse Road, Kingston, RI 02881 USA

Cancer is a major public health problem worldwide. Colon cancer ranks as the third most common causes of cancer mortality in the United States, with an estimated 96,830 new cases and 50,310 deaths in 2014. Colon cancer develops in the digestive tract where benign growths called polyps transform into malignant tumors. Colon cancer cells invade and destroy nearby tissue ...


A Survey Of Antimicrobial Stewardship Practices In The Western United States: Successes And Challenges, Gayle Louise Allenback 2014 University of Nevada, Las Vegas

A Survey Of Antimicrobial Stewardship Practices In The Western United States: Successes And Challenges, Gayle Louise Allenback

UNLV Theses/Dissertations/Professional Papers/Capstones

Antibiotics are one of the most important developments in medicine, and their ability to prevent and control infections has had a major impact in clinical medicine. However, the past three decades have shown an increase in multidrug-resistant organisms (MDROs) in both hospital patients and in the community, decreasing our ability to successfully control infection. Complicating the depletion of effective antimicrobials is the fact that, in the last 10 years, there has also been a decrease in the development of new antibacterial agents. Resistant infections have resulted in increased morbidity and mortality, with a consequential increase in healthcare costs. The utilization ...


Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino 2014 University of Connecticut

Assessing The Relationship Between The Blood-Air Partition Coefficient And Fractional Uptake Of Inspired Halothane, Acetone, And Ethanol Vapors In The Airways Of The C57bl/6j Mouse, Joshua Baruch Baldino

Honors Scholar Theses

The following series of studies investigates the elimination and uptake trends of halothane, acetone, and ethanol vapors in the airways of C57BL/6J mice. These vapors were chosen because they span a wide range of solubilities, as indicated by their blood-air partition coefficients, and are not associated with any significant airway metabolism or reactivity with tissue substrates in vivo. Mice were exposed to a homogeneous vapor mixture containing a 1:1:1 ratio of halothane, acetone, and ethanol at relative concentrations of approximately 10 ppm. Exposure studies were performed with mice in two states, conscious and deceased, in order to ...


Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle 2014 Liberty University

Childhood Obesity And Familial Hypercholesterolemia: Genetic Diseases That Contribute To Cardiovascular Disease, Alyssa Caudle

Senior Honors Theses

Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency. Mutated genes such as Fat Mass and Obesity Associated (FTO), Leptin (LEP), Leptin Receptor (LEPR), Melanocortin 4 Receptor (MC4R), Adiponectin C1Q and Collagen Domain Containing (ADIPOQ), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1), and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) all contribute to the development of childhood obesity. In the presence of high cholesterol caused by obesity, the genetic condition known as familial hypercholesterolemia is exacerbated. Familial hypercholesterolemia is caused by ...


Pharmacy Elder Abuse Assessment Project, Alexandrea Ham 2014 Boise State University

Pharmacy Elder Abuse Assessment Project, Alexandrea Ham

College of Health Sciences Presentations

Purpose: The purpose of this project is to evaluate the perceptions of students at the College of Pharmacy at Idaho State University on the topic of elder abuse. Methods: The study will be conducted by using a web-based survey developed by the researchers. A thirteen question survey will be administered to a convenience sample of students at the College of Pharmacy to assess their current understandings and perceptions on the topic of elder abuse. The survey is also intended to help as an educational component by helping students identify red flags of abuse and neglect and gives direction on how ...


Natural Products As Therapeutic Agents In Cancer Treatment, Trevor Stump, Lauren P. Williams, Brittany Santee, Chelsae Ward, Rachel Kunze, Denise S. Simpson, Dr. Samson Amos 2014 Cedarville University

Natural Products As Therapeutic Agents In Cancer Treatment, Trevor Stump, Lauren P. Williams, Brittany Santee, Chelsae Ward, Rachel Kunze, Denise S. Simpson, Dr. Samson Amos

The Research and Scholarship Symposium

Cancer accounts for 25% of deaths in the United States, and brain tumors greatly contribute to this percentage. However, relative to other types of cancers, brain tumors prove difficult to treat because they are heterogeneous, highly proliferative, highly invasive, and resistant to the traditional cancer treatments of chemotherapy and radiotherapy. Past studies have shown that flavonoids and curcuminoids, two classes of compounds derived from natural sources, are effective in inhibiting the development and metastasis of breast and lung cancer cells. Research has also indicated that these compounds have potential for treating brain tumors.

The purpose of this research is to ...


Evaluating The Bioavailability Of Carbamazepine Using A Novel Snedds Formulation, Gina M. Mattes, Zachary A. Wallace, Derrick L. Chapman, Jinwon Byun, Rebecca A. Kyper, Elisha R. Injeti 2014 Cedarville University

Evaluating The Bioavailability Of Carbamazepine Using A Novel Snedds Formulation, Gina M. Mattes, Zachary A. Wallace, Derrick L. Chapman, Jinwon Byun, Rebecca A. Kyper, Elisha R. Injeti

The Research and Scholarship Symposium

Carbamazepine (CBZ) is an anticonvulsant drug primarily used to treat epilepsy, bipolar disorder, trigeminal and glossopharyngeal neuralgia. CBZ is a lipophilic, poorly soluble drug that belongs to the class-2 category according to the Biopharmaceutics Classification System. As a class-2 drug, the plasma concentration of CBZ is limited by its ability to diffuse across biological membranes. To increase its bioavailability, different methods such as crystal modifications, particle size reduction, amorphization, cyclodextrin complexation, pH modification, and self-emulsification were explored. Of these methods, Self Nano Emulsifying Drug Delivery Systems (SNEDDS) have shown to reduce particle size of CBZ molecules and improve its solubility ...


2014 Symposium Overview, Cedarville University 2014 Cedarville University

2014 Symposium Overview, Cedarville University

The Research and Scholarship Symposium

Click the "Download" button in the top right corner to view the abstract booklet.


The Role Of Pharmacists In Primary Care Settings, Julie Cummings, McKenzie Shank, Nathanael Smith, Olumami Amaye, Cara Toms, Thaddeus Franz, Tracy Frame 2014 Cedarville University

The Role Of Pharmacists In Primary Care Settings, Julie Cummings, Mckenzie Shank, Nathanael Smith, Olumami Amaye, Cara Toms, Thaddeus Franz, Tracy Frame

The Research and Scholarship Symposium

Introduction: The profession of pharmacy has evolved from a dispensing role to an interdisciplinary clinical role in patient care. One area of patient care expertise is Medication Therapy Management Services (MTM), which includes services such as pharmacotherapy, medication therapy reviews, disease management, immunizations and other clinical services. Various studies have shown that pharmacists conducting MTM improve patient outcomes in some clinical settings. Amidst the valuable services all healthcare professionals are providing, increasing medical costs and a lack of primary care physicians have become overwhelming, potentially leading to negative patient outcomes. Gaps in communication between hospital, primary care clinics and community ...


A Random Sequential Mechanism Of Aminoglycoside Acetylation By Mycobacterium Tuberculosis Eis Protein, Oleg V. Tsodikov, Keith D. Green, Sylvie Garneau-Tsodikova 2014 University of Kentucky

A Random Sequential Mechanism Of Aminoglycoside Acetylation By Mycobacterium Tuberculosis Eis Protein, Oleg V. Tsodikov, Keith D. Green, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

An important cause of bacterial resistance to aminoglycoside antibiotics is the enzymatic acetylation of their amino groups by acetyltransferases, which abolishes their binding to and inhibition of the bacterial ribosome. Enhanced intracellular survival (Eis) protein from Mycobacterium tuberculosis (Mt) is one of such acetyltransferases, whose upregulation was recently established as a cause of resistance to aminoglycosides in clinical cases of drug-resistant tuberculosis. The mechanism of aminoglycoside acetylation by MtEis is not completely understood. A systematic analysis of steady-state kinetics of acetylation of kanamycin A and neomycin B by Eis as a function of concentrations of these aminoglycosides and the ...


Fast Disintegrating Crystalline Solid Dispersions Of Simvastatin For Incorporation Into Orodispersible Tablets, Ritesh M. Pabari, Asha Jamil, John G. Kelly, Zebunnissa Ramtoola 2014 Royal College of Surgeons in Ireland

Fast Disintegrating Crystalline Solid Dispersions Of Simvastatin For Incorporation Into Orodispersible Tablets, Ritesh M. Pabari, Asha Jamil, John G. Kelly, Zebunnissa Ramtoola

School of Pharmacy Articles

Aim : Spray dried solid dispersion (SDP) of crystalline simvastatin (SIM) in a fast disintegrating matrix of superdisintegrants was studied as a method to enhance SIM dispersibility, rheology, compactibility and compressibility for incorporation into orodispersible tablets (ODTs).

Materials and Methods: The superdisintegrants investigated were crospovidone (CP), sodium starch glycollate (SSG) and calcium silicate (CS) were spray dried with simvastatin to form SDPs.

Results: The SDPs were characterized and the median particle size of SDPs was similar or greater than the SIM, contributing to good rheology of SDPs, while the low bulk density of SDPs indicated a high compactibility. Interestingly electron micrographs ...


Tumor Radiation Therapy Creates Therapeutic Vaccine Responses To The Colorectal Cancer Antigen Gucy2c., Matthew Witek, Erik S Blomain, Michael Sullivan Magee, Bo Xiang, Scott A Waldman, Adam E. Snook 2014 Thomas Jefferson University

Tumor Radiation Therapy Creates Therapeutic Vaccine Responses To The Colorectal Cancer Antigen Gucy2c., Matthew Witek, Erik S Blomain, Michael Sullivan Magee, Bo Xiang, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

PURPOSE: Radiation therapy (RT) is thought to produce clinical responses in cancer patients, not only through direct toxicity to cancer cells and supporting tumor stroma cells, but also through activation of immunologic effectors. More recently, RT has potentiated the local and systemic effects of cancer immunotherapy (IT). However, combination regimens that maximize immunologic and clinical efficacy remain undefined.

METHODS AND MATERIALS: We evaluated the impact of local RT on adenoviral-mediated vaccination against the colorectal cancer antigen GUCY2C (Ad5-GUCY2C) in a murine subcutaneous tumor model using mouse CT26 colon cancer cells (CT26-GUCY2C). Immune responses were assessed by ELISpot, and clinical responses ...


Antiplasmodial And Antioxidant Isoquinoline Alkaloids From Dehaasia Longipedicellata, Kok Hoong Leong 2014 SelectedWorks

Antiplasmodial And Antioxidant Isoquinoline Alkaloids From Dehaasia Longipedicellata, Kok Hoong Leong

Kok Hoong Leong

The crude extract of the bark of Dehaasia longipedicellata exhibited antiplasmodial activity against the growth of Plasmodium falciparum K1 isolate (resistant strain). Phytochemical studies of the extract led to the isolation of six alkaloids: two morphinandienones, (+)-sebiferine (1) and (−)-milonine (2); two aporphines, (−)-boldine (3) and (−)-norboldine (4); one benzlyisoquinoline, (−)-reticuline (5); and one bisbenzylisoquinoline, (−)-O-O-dimethylgrisabine (6). Their structures were determined on the basis of 1D and 2D NMR, IR, UV, and LCMS spectroscopic techniques and upon comparison with literature values. Antiplasmodial activity was determined for all of the isolated compounds. They showed potent to moderate activity with IC50 values ...


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