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Interprofessional Simulation Learning With Nursing And Pharmacy Students: A Qualitative Study, Pauline Paul, Joanne K. Olson, Cheryl Sadowski, Brian Parker, Angele Alook, Deirdre Jackman, Cheryl Cox, Stewart MacLennan 2014 Canadian Association of Schools of Nursing

Interprofessional Simulation Learning With Nursing And Pharmacy Students: A Qualitative Study, Pauline Paul, Joanne K. Olson, Cheryl Sadowski, Brian Parker, Angele Alook, Deirdre Jackman, Cheryl Cox, Stewart Maclennan

Quality Advancement in Nursing Education - Avancées en formation infirmière

Health science students are increasingly learning in simulated situations within their own disciplines, but interprofessional simulation learning (ISL) does not occur as often and is rarely investigated. This research explored perceptions of undergraduate nursing (n=5) and pharmacy (n=4) students with respect to how ISL contributed to discipline-specific learning, to learning about the other profession, and to the development of interprofessional skills. The students were exposed to three ISL activities with data gathered from observation of the simulation sessions, individual interviews, and field notes. Content analysis was conducted. Student participants described the ISL activities as a positive learning experience ...


Effect Of Twin Screw Granulator Process Parameters On Granule Attributes, Haosheng Xu, Ridade Sayin, James Litster 2014 Purdue University

Effect Of Twin Screw Granulator Process Parameters On Granule Attributes, Haosheng Xu, Ridade Sayin, James Litster

The Summer Undergraduate Research Fellowship (SURF) Symposium

Twin screw wet granulation has been considered as an efficient and effective technique of manufacturing granules (agglomerates made up of small particles) and has been widely applied in pharmaceutical industry. However, narrow granule size distributions are difficult to achieve. This study aims to elucidate the effect of process parameters such as liquid feed rate and screw configuration on the granule attributes through granule characterization. The methods used are sieve analysis (for size distribution), liquid distribution (determining the dye concentration in the granules) and density and porosity (percentage gas volume in the granule) analyses. A sieve shaker is used to divide ...


Exploring The Effect Of Solution Speciation On Crystallization Outcome, David M. Harvey, Arjun Kalra, Tonglei Li 2014 Purdue University

Exploring The Effect Of Solution Speciation On Crystallization Outcome, David M. Harvey, Arjun Kalra, Tonglei Li

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the field of pharmaceuticals, the crystallization process significantly impacts the purity, morphology and polymorphism of active pharmaceutical ingredients (API), all of which are important in drug development. Polymorphism is the existence of more than one solid-state form of the same chemical entity. Tolfenamic acid (TFA), a Non-Steroid Anti-inflammatory drug (NSAID), has been shown to exhibit a unique physical phenomenon called concomitant polymorphism, whereby two polymorphs crystallize from the solution simultaneously. From previous work, it has been established that solution speciation i.e. the presence of monomers or dimers of TFA in solution is concentration and temperature dependent. This study ...


The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith, Ph.D. 2014 Chapman University

The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith, Ph.D.

e-Research: A Journal of Undergraduate Work

Pancreatic cancer is the fourth leading cause of cancer death in the United States. There have been several reports indicating that phytochemicals in fruits can reduce the risk of cancer due to the anti-oxidant and anti-inflammatory effects of the polyphenols. Our lab has shown that pomegranate juice extract (PJE) has anti-proliferative and pro-apoptotic effects in human pancreatic cancer cells. In the past, we have shown that cells adhere more strongly to the plate when treated with PJE. This observation prompted an investigation of how PJE regulates cell adhesion proteins. Previously, our lab investigated E-cadherin, a cell adhesion protein. Upon activation ...


2014 White Coat Ceremony Program, School of Pharmacy, Cedarville University 2014 Cedarville University

2014 White Coat Ceremony Program, School Of Pharmacy, Cedarville University

2014 White Coat Ceremony Documents

No abstract provided.


Pledge Of Professionalism, School of Pharmacy, Cedarville University 2014 Cedarville University

Pledge Of Professionalism, School Of Pharmacy, Cedarville University

2014 White Coat Ceremony Documents

No abstract provided.


2014 White Coat Ceremony Invitation, School of Pharmacy, Cedarville University 2014 Cedarville University

2014 White Coat Ceremony Invitation, School Of Pharmacy, Cedarville University

2014 White Coat Ceremony Documents

No abstract provided.


Class Of 2018, School of Pharmacy, Cedarville University 2014 Cedarville University

Class Of 2018, School Of Pharmacy, Cedarville University

2014 White Coat Ceremony Documents

No abstract provided.


Alternative Reaction Pathways To Metformin Hydrochloride, Mohammed S. Suleiman, Stephen A. Reeves, Jorge E. Gatica 2014 Cleveland State University

Alternative Reaction Pathways To Metformin Hydrochloride, Mohammed S. Suleiman, Stephen A. Reeves, Jorge E. Gatica

Undergraduate Research Posters 2014

Metformin Hydrochloride is an important pharmaceutical used for the treatment of type 2 diabetes. The current manufacturing of this product involves a well-known and proven process. The process includes the dissolution and reaction, followed by the precipitation of Metformin Hydrochloride. Although reliable and effective, the current process relies on the use of a solvent; which later needs to be eliminated from the precipitates. The purpose of this project is the investigation of an alternative reaction pathway which will avoid the use of solvents and simplify the final purification stage. The anticipated benefits include reduced costs for the processing and a ...


Assessment Of Resident And Faculty Preferences For Clinical Pharmacy Services Within A Developing Family Medicine Residency Program, Kerry Haney 2014 University of Montana

Assessment Of Resident And Faculty Preferences For Clinical Pharmacy Services Within A Developing Family Medicine Residency Program, Kerry Haney

University Grant Program Reports

No abstract provided.


Investigating Propargyl-Linked Antifolates In Inhibiting Bacterial And Fungal Dihydrofolate Reductase, Joshua Andrade 2014 University of Connecticut

Investigating Propargyl-Linked Antifolates In Inhibiting Bacterial And Fungal Dihydrofolate Reductase, Joshua Andrade

Honors Scholar Theses

Antimicrobial agents have been invaluable in reducing illness and death associated with bacterial infection. However, over time, bacteria have evolved resistance to all major drug classes as a result of selective pressure. The advancement of new drug compounds is therefore vital. The Anderson-Wright Lab has focused on developing potent and selective inhibitors of dihydrofolate reductase (DHFR), an enzyme key in cell proliferation and survival, in several pathogenic species. The lab has found that a set of compounds, known as propargyl-linked antifolates, are DHFR inhibitors that are both biologically effective and have strong pharmacokinetic properties.

The efficacy of novel propargyl-linked antifolates ...


Electrochemical Investigations Of Benzanthrone, Antonio Trevino, Kefe Onchoke 2014 Stephen F. Austin State University

Electrochemical Investigations Of Benzanthrone, Antonio Trevino, Kefe Onchoke

Undergraduate Research Conference

No abstract provided.


Radiation-Induced Genomic Instability And Line-1 Hypomethylation In Radiographers, Yoon Hee Cho 2014 University of Montana

Radiation-Induced Genomic Instability And Line-1 Hypomethylation In Radiographers, Yoon Hee Cho

University Grant Program Reports

Genomic instability is an important factor in cancer induced by ionizing radiation. Global DNA hypomethylation has been recently proposed as a potential biomarker for cancer risk through genomic instability. However the association between low-dose ionizing radiation exposure and DNA methylation changes is unclear. This study aimed to understand the epigenetic mechanisms associated with low-level radiation exposure and radiation-induced genomic instability (RIGI) among industrial radiographers.


Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey IV 2014 Northern Michigan University

Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv

NMU Master's Theses

Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing general locomotor activity as measured in an open field test. The present study sought to examine the effects of the neurotensin NTS1 receptor agonist PD149163 and the tricyclic antidepressant drug imipramine on immobility in the forced swim test and on locomotor activity ...


Production Of Recombinant Human Coagulation Factor Ix By Transgenic Pig, Weijie Xu 2014 University of Nebraska - Lincoln

Production Of Recombinant Human Coagulation Factor Ix By Transgenic Pig, Weijie Xu

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

Hemophilia B is the congenital bleeding disorder caused by deficiency in functional coagulation factor IX (FIX) and about 28,000 patients worldwide in 2012. And current treatment is restricted to protein-replacement therapy, which required FIX concentrates for patients’ life-time. Approximately 1 billion units FIX were consumed in 2012. However, still about 70-80% patients, mostly in developing countries, received inadequate or no treatment because of the unavailable and/or unaffordable FIX concentrates. Considering safety reasons, e.g. transmission of blood-borne diseases, the recombinant human FIX (rFIX) is recommended other than the plasma-derived FIX. However, only one rFIX is currently available on ...


Neuroinflammation And Neurodegeneration In Adult Rat Brain From Binge Ethanol Exposure: Abrogation By Docosahexaenoic Acid, Nuzhath Tajuddin, Kwan-Hoon Moon, Simon Alex Marshall, Kimberly Nixon, Edward J. Neafsey, Hee-Yong Kim, Michael A. Collins 2014 University of Kentucky

Neuroinflammation And Neurodegeneration In Adult Rat Brain From Binge Ethanol Exposure: Abrogation By Docosahexaenoic Acid, Nuzhath Tajuddin, Kwan-Hoon Moon, Simon Alex Marshall, Kimberly Nixon, Edward J. Neafsey, Hee-Yong Kim, Michael A. Collins

Pharmaceutical Sciences Faculty Publications

Evidence that brain edema and aquaporin-4 (AQP4) water channels have roles in experimental binge ethanol-induced neurodegeneration has stimulated interest in swelling/edema-linked neuroinflammatory pathways leading to oxidative stress. We report here that neurotoxic binge ethanol exposure produces comparable significant effects in vivo and in vitro on adult rat brain levels of AQP4 as well as neuroinflammation-linked enzymes: key phospholipase A2 (PLA2) family members and poly (ADP-ribose) polymerase-1 (PARP-1). In adult male rats, repetitive ethanol intoxication (3 gavages/d for 4 d, ∼ 9 g/kg/d, achieving blood ethanol levels ∼ 375 mg/dl; "Majchrowicz" model) significantly increased AQP4, Ca+2-dependent PLA2 ...


Posaconazole Tablet Pharmacokinetics: Lack Of Effect Of Concomitant Medications Altering Gastric Ph And Gastric Motility In Healthy Subjects., Walter K. Kraft, Peter S. Chang, Marlou L P S van Iersel, Hetty Waskin, Gopal Krishna, Wendy M Kersemaekers 2014 Thomas Jefferson University

Posaconazole Tablet Pharmacokinetics: Lack Of Effect Of Concomitant Medications Altering Gastric Ph And Gastric Motility In Healthy Subjects., Walter K. Kraft, Peter S. Chang, Marlou L P S Van Iersel, Hetty Waskin, Gopal Krishna, Wendy M Kersemaekers

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Posaconazole oral suspension is an extended-spectrum triazole that should be taken with food to maximize absorption. A new posaconazole tablet formulation has demonstrated improved bioavailability over the oral suspension in healthy adults in a fasting state. This study evaluated the effects of concomitant medications altering gastric pH (antacid, ranitidine, and esomeprazole) and gastric motility (metoclopramide) on the pharmacokinetics of posaconazole tablets. This was a prospective open-label 5-way crossover study in 20 healthy volunteers. In each treatment period, a single 400-mg dose (4 100-mg tablets) of posaconazole was administered alone or with 20 ml antacid (2 g of aluminum hydroxide and ...


2009 A/H1n1 Influenza Vaccination In Pregnancy: Uptake And Pregnancy Outcomes - A Historical Cohort Study., Brian J Cleary, Úna Rice, Maeve Eogan, Nehad Metwally, Fionnuala McAuliffe 2014 Royal College of Surgeons in Ireland

2009 A/H1n1 Influenza Vaccination In Pregnancy: Uptake And Pregnancy Outcomes - A Historical Cohort Study., Brian J Cleary, Úna Rice, Maeve Eogan, Nehad Metwally, Fionnuala Mcauliffe

School of Pharmacy Articles

OBJECTIVES: To describe the uptake of 2009 A/H1N1 influenza vaccination among pregnant women and determine if vaccination was associated with adverse pregnancy outcomes.

STUDY DESIGN: A historical cohort study was performed using booking, delivery suite and neonatal unit discharge records from the Coombe Women and Infants University Hospital, Dublin, Ireland. Singleton deliveries to women pregnant before (December 2008-September 2009) and during the pandemic (December 2009-September 2010) were included. Information on vaccination status and type of vaccine was collected on admission to the delivery suite. Logistic regression analyses were used to determine maternal characteristics associated with vaccination. Pregnancy outcomes were ...


Development Of A Partnership For International Rural Advanced Pharmacy Practice Experiences, Emily K. Flores, Linsey A. Courtney 2014 East Tennessee State University

Development Of A Partnership For International Rural Advanced Pharmacy Practice Experiences, Emily K. Flores, Linsey A. Courtney

International Journal of Health Sciences Education

Objective. To design a faculty-guided international elective Advanced Pharmacy Practice Expereince (APPE) in partnership with a medical relief organization. To expose students to pharmacy-related opportunities in non-traditional settings focused on an indigent population, while obtaining a global perspective on healthcare.

Methods. The College of Pharmacy partnered with an international medical relief organization utilizing their resources for trip planning and in-country logistics to provide a framework for a pharmacy student rotation. The international trip is a portion of the calendar month rotation, while the balance is faculty-guided discussion groups, involvement in formulary planning, developing educational materials, and local medical relief work ...


An Interprofessional Falls Assessment Clinic Model To Develop Collaborative Team Skills Among Health Professional Students, Tracey Vause-Earland, MS, OTR/L, Leigh Ann Hewston, PT, MEd, Cecilia Borden, EdD, MSN, Brooke Salzman, MD, Emily Hajjar, PharmD, Ellen Furman, MSW, Christine Hsieh, MD, Susan Parks, MD 2014 Thomas Jefferson University

An Interprofessional Falls Assessment Clinic Model To Develop Collaborative Team Skills Among Health Professional Students, Tracey Vause-Earland, Ms, Otr/L, Leigh Ann Hewston, Pt, Med, Cecilia Borden, Edd, Msn, Brooke Salzman, Md, Emily Hajjar, Pharmd, Ellen Furman, Msw, Christine Hsieh, Md, Susan Parks, Md

Department of Occupational Therapy, Presentations

BACKGROUND

  • Older adults are at increased risk for falls and fall related injuries, leading to loss of independence, disability, and increased mortality.
  • Preventing injury and falls is a national Healthy People 2010 objective. However, physicians and other health professionals frequently fail to incorporate known evidence into usual care. Screening for falls is not consistently performed as an essential assessment in older adults by primary care providers.
  • Multidisciplinary assessment can be an important component in preventing falls in community dwelling adults.
  • In new practice models, such as the Chronic Care Model, there is an emphasis on interdisciplinary collaboration, however health professions ...


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