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Utilization And Costs Of Compounded Medications For Commercially Insured Patients, 2012 – 2013, Timothy McPherson, Patrick Fontane PhD, Express Scripts Holding Company 2016 Southern Illinois University Edwardsville

Utilization And Costs Of Compounded Medications For Commercially Insured Patients, 2012 – 2013, Timothy Mcpherson, Patrick Fontane Phd, Express Scripts Holding Company

SIUE Faculty Research, Scholarship, and Creative Activity

Background: Although compounding has a long-standing tradition in clinical practice, insurers and pharmacy benefit managers have instituted policies to decrease claims for compounded medications, citing questions about their safety, efficacy, high costs, and lack of Food and Drug Administration (FDA) approval. There are no reliable published data on the extent of compounding by community pharmacists nor the fraction of patients who use compounded medications. Prior research suggests that compounded medications represent a relatively small proportion of prescription medications, but these surveys were limited by small sample sizes, subjective data collection methods, and low response rates.

Objective: To determine the number ...


Evaluation Of Current Heparin Weight Based Protocol In Obese Patients, Marie Lafosse, Simon Leung, Carla Hawkins, Madeline Camejo 2016 Joe DiMaggio Children's Hospital, Hollywood, Florida

Evaluation Of Current Heparin Weight Based Protocol In Obese Patients, Marie Lafosse, Simon Leung, Carla Hawkins, Madeline Camejo

Internet Journal of Allied Health Sciences and Practice

Purpose: To evaluate the difference in achieving goal activated partial thromboplastin time (aPTT) within 24 hours utilizing the institutional heparin weight based protocol between obese and non-obese patients. Methods: Retrospective, non-randomized, open label chart review in a community based hospital. Patients age 18 years or older receiving heparin therapy for greater than or equal to 24 hours identified. Patients were excluded if the protocol was utilized for acute coronary syndrome or interrupted within the initial 24 hours of therapy. Patients were also excluded if any deviations from the protocol were identified. The primary endpoint evaluated the difference in achieving goal ...


Total Quality System Breakdowns In Outsourced Clinical Trials, Hemali Barrios 2016 Walden University

Total Quality System Breakdowns In Outsourced Clinical Trials, Hemali Barrios

Walden Dissertations and Doctoral Studies

Numerous deaths, tragedies, and underreported drug side effects occur in outsourced clinical trials. Total quality system breakdowns occur even though quality agreement contracts and quality management systems are used by pharmaceutical organizations. The purpose of this single case study was to explore strategies clinical quality assurance managers use to avoid breakdowns in quality with outsourced clinical trials in Asia-Pacific countries. The study included a purposeful sample of 15 clinical quality assurance managers from 1 pharmaceutical organization located in the Northeast region of the United States. The conceptual framework was von Bertalanffy's general systems theory. Face-to-face semistructured interviews or e-mail ...


Methemoglobinemia In Acetaminophen Overdose And Glucose-6-Phosphate Dehydrogenase Deficiency, Maelen Ignacio, PharmD, Colin Craft, MD, Fern M. Martin, MD, Cara McDaniel, PharmD, BCPS 2016 Thomas Jefferson University Hospital

Methemoglobinemia In Acetaminophen Overdose And Glucose-6-Phosphate Dehydrogenase Deficiency, Maelen Ignacio, Pharmd, Colin Craft, Md, Fern M. Martin, Md, Cara Mcdaniel, Pharmd, Bcps

Jefferson College of Pharmacy Posters

Background:

  • Methemoglobin (MetHb) is formed when the iron moiety of hemoglobin (Hgb) is oxidized from ferrous (Fe2+) to ferric (Fe3+) state à impaired O2 delivery to tissues
  • Acetaminophen Metabolism:

~90% is metabolized in liver via sulfation and glucuronidation

remainder is metabolized via CYP450 to a toxic oxidizing agent, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified via glutathione1

  • Acute Acetaminophen Overdose:

saturates sulfation and glucuronidation pathways

depletes glutathione stores

leads to excess NAPQI à oxidative stress à methemoglobinemia1

  • MetHb Reduction Pathway:

cytochrome b5 reductase removes 95% to 99% of endogenous MetHb

nicotinamide adenine dinucleotide phosphate (NADPH


Mechanisms Of Action Of Antiseizure Drugs And The Ketogenic Diet., Michael A. Rogawski, Jong M. Rho, Wolfgang Löscher 2015

Mechanisms Of Action Of Antiseizure Drugs And The Ketogenic Diet., Michael A. Rogawski, Jong M. Rho, Wolfgang Löscher

Michael A. Rogawski

Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic treatment for people with epilepsy, but not all patients become free of seizures. The ketogenic diet is one treatment option for drug-resistant patients. Both types of therapy exert their clinical effects through interactions with one or more of a diverse set of molecular targets in the brain. ASDs act by modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; by enhancement of gamma-aminobutyric acid (GABA)-mediated inhibition through effects on GABA-A receptors, the GABA transporter 1 (GAT1) GABA uptake transporter, or GABA transaminase; through interactions ...


Characterization Of Physicochemical And Spectroscopic Properties Of Biofield Energy Treated Bio Peptone, Mahendra Trivedi 2015 Selected Works

Characterization Of Physicochemical And Spectroscopic Properties Of Biofield Energy Treated Bio Peptone, Mahendra Trivedi

Mahendra Kumar Trivedi

Bio peptone is a combination of enzymatic digest of animal tissues and casein; and generally used for the growth of several varieties of microbes. The aim of present study was to investigate the impact of biofield energy treatment on the physicochemical and spectroscopic properties of bio peptone. The present study was carried out in two groups i.e. control and treated. The control group was kept without treatment, while the treated group was subjected to Mr. Trivedi’s biofield energy treatment. Subsequently, both the samples were assessed using numerous analytical techniques. The X-ray diffractograms (XRD) showed the halo patterns of ...


Physical, Spectroscopic And Thermal Characterization Of Biofield Treated Fish Peptone, Mahendra Trivedi 2015 Trivedi Global Inc.

Physical, Spectroscopic And Thermal Characterization Of Biofield Treated Fish Peptone, Mahendra Trivedi

Mahendra Kumar Trivedi

The by-products of industrially processed fish are enzymatically converted into fish protein isolates and hydrolysates having a wide biological activity and nutritional properties. However, the heat processing may cause their thermal denaturation thereby causing the conformational changes in them. The present study utilized the strategy of biofield energy treatment and analysed its impact on various properties of the fish peptone as compared to the untreated (control) sample. The fish peptone sample was divided into two parts; one part was subjected to Mr. Trivedi’s biofield treatment, coded as the treated sample and another part was coded as the control. The ...


The Potential Impact Of Biofield Energy Treatment On The Atomic And Physical Properties Of Antimony Tin Oxide Nanopowder, Mahendra Trivedi 2015 Trivedi Global Inc.

The Potential Impact Of Biofield Energy Treatment On The Atomic And Physical Properties Of Antimony Tin Oxide Nanopowder, Mahendra Trivedi

Mahendra Kumar Trivedi

Antimony tin oxide (ATO) is known for its high thermal conductivity, optical transmittance, and wide energy band gap, which makes it a promising material for the display devices, solar cells, and chemical sensor industries. The present study was undertaken to evaluate the effect of biofield energy treatment on the atomic and physical properties of ATO nanopowder. The ATO nanopowder was divided into two parts: control and treated. The treated part was subjected to Mr. Trivedi’s biofield energy treatment. The control and treated samples were analyzed using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and electron spin resonance (ESR ...


Characterization Of Physical, Thermal And Spectral Properties Of Biofield Treated 2-Aminopyridine, Mahendra Trivedi 2015 Selected Works

Characterization Of Physical, Thermal And Spectral Properties Of Biofield Treated 2-Aminopyridine, Mahendra Trivedi

Mahendra Kumar Trivedi

2-Aminopyridine is an important compound, which is used as intermediate for the synthesis of pharmaceutical compounds. The present work was aimed to assess the effect of Mr. Trivedi’s biofield energy treatment on the physical, thermal and spectral characteristics of 2-AP. The work was accomplished by dividing the sample in two parts i.e. one part was remained untreated, and another part had received biofield energy treatment. Subsequently, the samples were analyzed using various characterization techniques such as X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, ultra violet-visible spectroscopy, and Fourier transform infrared spectroscopy. The XRD analysis revealed a decrease in ...


An Online Approach To Interprofessional Education, E. Adel Herge, OTD, OTR/L, FAOTA, Amber E. King, PharmD, BCPS 2015 Department of Occupational Therapy, Thomas Jefferson University

An Online Approach To Interprofessional Education, E. Adel Herge, Otd, Otr/L, Faota, Amber E. King, Pharmd, Bcps

Jefferson Center for InterProfessional Education​ (JCIPE) Interprofessional Education and Care e-Newsletter​

Despite increasing interest in providing interprofessional education (IPE) opportunities for health profession students, the logistics of scheduling and integrating diverse curriculums remain challenging. Several models to address these potential barriers have been proposed and utilized (Blue et al, 2010). Faculty from three colleges within Thomas Jefferson University developed an asynchronous online interprofessional course as one solution to overcome logistical barriers to IPE.

Interprofessional Grand Rounds is offered to third year pharmacy students and second year occupational therapy (OT) students in the fall semester. The course utilizes a variety of learning activities to evaluate the influence of current public health and ...


Examining Health Mentors’ Perceptions Of Student Teamwork, Deirdre Yarosh, BS, MA, PharmD Student, Elena M. Umland, PharmD 2015 College of Pharmacy, Thomas Jefferson University

Examining Health Mentors’ Perceptions Of Student Teamwork, Deirdre Yarosh, Bs, Ma, Pharmd Student, Elena M. Umland, Pharmd

Jefferson Center for InterProfessional Education​ (JCIPE) Interprofessional Education and Care e-Newsletter​

Statement of Issue:

With the increasing emphasis on interprofessional teamwork in healthcare, the need to train future health care professionals to work together as a functional team to provide patient-centered care is clear. Limited information exists regarding education of health care students and teamwork training.1,2 This research evaluates student team performance.

Background:

Thomas Jefferson University (TJU) offers a unique, two-year program emphasizing delivery of patient-centered care and providing valuable skill development by pairing interprofessional student teams with a Health Mentor (HM). The HM is an adult community volunteer with one or more chronic health condition(s). Student teams ...


Generic Medicines And Generic Substitution: Contrasting Perspectives Of Stakeholders In Ireland., Aisling O'Leary, Cara Usher, Matthew Lynch, M Hall, L Hemeryk, Susan Spillane, Paul Gallagher, Michael Barry 2015 Royal College of Surgeons In Ireland

Generic Medicines And Generic Substitution: Contrasting Perspectives Of Stakeholders In Ireland., Aisling O'Leary, Cara Usher, Matthew Lynch, M Hall, L Hemeryk, Susan Spillane, Paul Gallagher, Michael Barry

School of Pharmacy Articles

BACKGROUND: The Health (Pricing and Supply of Medical Goods) Act 2013 passed into law in July 2013 and legislated for generic substitution in Ireland. The aim of the study was to ascertain the knowledge and perceptions of stakeholders i.e. patients, pharmacists and prescribers, of generic medicines and to generic substitution with the passing of legislation.

METHODS: Three stakeholder specific questionnaires were developed to assess knowledge of and perceptions to generic medicines and generic substitution. Purposive samples of patients, prescribers and pharmacists were analysed. Descriptive quantitative and qualitative analyses were undertaken.

RESULTS AND DISCUSSION: A total of 762 healthcare professionals ...


Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li 2015 Southwest University, Chongqing, China

Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li

Faculty Publications, Department of Psychology

The present study characterized the behavioral mechanisms of avoidance–disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as CS1 and pure tone as CS2). Only the highest dose (50.0 mg/kg) produced a ...


Perioperative Nonopioid Agents For Pain Control In Spinal Surgery., Anna Rivkin, Mark Rivkin 2015 Philadelphia College of Osteopathic Medicine

Perioperative Nonopioid Agents For Pain Control In Spinal Surgery., Anna Rivkin, Mark Rivkin

Mark Rivkin

PURPOSE: Commonly used nonopioid analgesic agents that are incorporated into multimodal perioperative pain management protocols in spinal surgery are reviewed.

SUMMARY: Spinal procedures constitute perhaps some of most painful surgical interventions, as they often encompass extensive muscle dissection, tissue retraction, and surgical implants, as well as prolonged operative duration. Perioperative nonopioid analgesics frequently used in multimodal protocols include gabapentin, pregabalin, acetaminophen, dexamethasone, ketamine, and nonsteroidal antiinflammatory drugs (NSAIDs). There is evidence to suggest that gabapentin is safe and effective in reducing opioid consumption and pain scores at optimal doses of 600-900 mg orally administered preoperatively. Pregabalin 150-300 mg orally perioperatively ...


Using A Cost Benefit Analysis To Support The Development Of A Comprehensive Business Model For A Pre-Filled, Pre-Labeled, Pre-Diluted, Sterilely Packaged, Ready-To-Use, Syringe-Based Anesthesia Delivery System, Lance B. Kennedy 2015 University of Southern Mississippi

Using A Cost Benefit Analysis To Support The Development Of A Comprehensive Business Model For A Pre-Filled, Pre-Labeled, Pre-Diluted, Sterilely Packaged, Ready-To-Use, Syringe-Based Anesthesia Delivery System, Lance B. Kennedy

Doctoral Nursing Capstone Projects

The foundation of Certified Registered Nurse Anesthetists’ (CRNAs) entire profession is built on the ability to provide anesthetic services using a variety of medications in the safest, most efficient, cost-effective way possible. The purpose of this capstone is to address, via a comprehensive cost benefit analysis, whether pre-filled syringe drug trays are a more cost-effective way to address problems as compared to vial-filled drug trays and to implement the necessary transitions in order to improve outcomes. There are a number of identifiable problems related to anesthesia medication delivery via vial-filled medication, including increased cost of healthcare, decreased patient safety to ...


Phenylephrine Versus Ephedrine: Safest Vasopressor For The Neonate During Caesarean Section, James S. Hale Jr. 2015 University of Southern Mississippi

Phenylephrine Versus Ephedrine: Safest Vasopressor For The Neonate During Caesarean Section, James S. Hale Jr.

Doctoral Nursing Capstone Projects

One of the most common side effects of spinal anesthesia is the development of hypotension. Data collected has determined that 80% of parturients that undergo spinal anesthesia for this mode of delivery experience hypotension (Chestnut et al., 2014).

Hypotension, if sustained and severe, can lead to fetal hypoxia, neonatal depression or injury, and decreased uteroplacental perfusion. Hypotension can also cause severe health issues for the parturient including apnea, altered level of consciousness, cardiac arrest, and pulmonary aspiration. This systematic review of the literature was conducted to determine whether the administration of phenylephrine or ephedrine was safer for the neonate to ...


Pharmacy Admissions: The Dating Game, Travis Mentch, Aaron Oliver, Joel Sanvee, Godfred Atta-Effa, Maame Debrah-Pinamang, Monica Saad, Aleda Chen, Stephanie M. Cailor, Kate Ford 2015 Cedarville University

Pharmacy Admissions: The Dating Game, Travis Mentch, Aaron Oliver, Joel Sanvee, Godfred Atta-Effa, Maame Debrah-Pinamang, Monica Saad, Aleda Chen, Stephanie M. Cailor, Kate Ford

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Abstract:

Background:

According to the American Association of Colleges of Pharmacy, as of July 2015, there are 132 US-based colleges and schools of pharmacy. The decision on which school students choose can be one of the most important decisions they will make in their lives. Many factors can affect these decisions, such as: curricular content, location/facilities, finances, and diversity. Although there are many factors that impact student decisions, the relative importance of these factors is unknown. This project will determine the importance of these factors in order to aid school recruitment.

Objectives:

The objective of this project is to ...


Retrospective Study To Evaluate Nausea, Vomiting, And Hypersensitivity Reactions In Patients Receiving Folfox For Colorectal Cancer At An Infusion Center Not Routinely Administering Prophylactic Dexamethasone, Marissa Csovelak PharmD, Melissa Kratz RN, MSN, AOCN, Janine Barnaby RPh, BCOP 2015 Lehigh Valley Health Network

Retrospective Study To Evaluate Nausea, Vomiting, And Hypersensitivity Reactions In Patients Receiving Folfox For Colorectal Cancer At An Infusion Center Not Routinely Administering Prophylactic Dexamethasone, Marissa Csovelak Pharmd, Melissa Kratz Rn, Msn, Aocn, Janine Barnaby Rph, Bcop

Department of Pharmacy

No abstract provided.


Daptomycin Non-Susceptible Mrsa Bacteremia: A Case Report, Jaclyn Cusumano, PharmD, Anna Marie Morlino, PharmD, Andrew Moyer, PharmD 2015 Thomas Jefferson University Hospitals, Department of Pharmacy, Philadelphia, PA

Daptomycin Non-Susceptible Mrsa Bacteremia: A Case Report, Jaclyn Cusumano, Pharmd, Anna Marie Morlino, Pharmd, Andrew Moyer, Pharmd

Jefferson College of Pharmacy Posters

Background

Staphylococcus aureus1, 2, 3

  • One of the most common pathogens causing community-acquired and nosocomial infections
  • Has rapidly developed resistance to many antibiotics:

Daptomycin 2

  • Bactericidal cyclic lipopeptide antibiotic
  • Possesses negative charge which attracts calcium to form cationic complex
  • Interacts with negatively charged phospholipid heads on bacterial cell membranes, leading to membrane depolarization and cell death

Daptomycin non-susceptible (DNS) S. aureus 2, 4, 5

  • Extremely rare - About 60 clinical cases reported
  • Defined by an MIC greater than 1 mcg/mL
  • Potential mechanisms include:

– Changes in cell membrane and cell wall structure alter daptomycin’s permeability2

  • Overexpression and dysregulation ...


Comparison Of Pediatric Outpatient Antibiotic Prescribing Patterns For Specified Indications In Primary Care Practices, Samantha Spishock PharmD, Kristen Held Wheatley PharmD, BCOP, Tibisay Villalobos MD, FAAP 2015 Lehigh Valley Health Network

Comparison Of Pediatric Outpatient Antibiotic Prescribing Patterns For Specified Indications In Primary Care Practices, Samantha Spishock Pharmd, Kristen Held Wheatley Pharmd, Bcop, Tibisay Villalobos Md, Faap

Department of Pharmacy

No abstract provided.


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