Open Access. Powered by Scholars. Published by Universities.®

Pharmacy and Pharmaceutical Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

1,130 Full-Text Articles 2,598 Authors 306,816 Downloads 78 Institutions

All Articles in Pharmacy and Pharmaceutical Sciences

Faceted Search

1,130 full-text articles. Page 1 of 39.

The Use Of Pbl In An Interprofessional Education Course For Health Care Professional Students, Kristine M. L'Ecuyer, David Pole, Sheila A. Leander 2015 Saint Louis University

The Use Of Pbl In An Interprofessional Education Course For Health Care Professional Students, Kristine M. L'Ecuyer, David Pole, Sheila A. Leander

Interdisciplinary Journal of Problem-Based Learning

A problem-based learning (PBL) framework was utilized in a series of six interprofessional team seminars (IPTS) for postbaccalaureate students from seven health professions. The goal of IPTS was to develop a collaborative practice-ready workforce prepared to respond to patient care needs through use of concrete examples, skills development, critical thinking, and problem solving in safe, faculty-facilitated small groups. The collaborative nature of PBL closely correlates with teaching methodologies of the IPTS series. This study analyzed critical reflection assignments of nursing students in accelerated programs to determine the effectiveness of IPTS at preparing students for interprofessional collaborative practice. Findings indicated that ...


Proteomic Signature Of The Murine Intervertebral Disc, Matthew R. McCann 2015 Western University

Proteomic Signature Of The Murine Intervertebral Disc, Matthew R. Mccann

Physiology and Pharmacology Publications

Low back pain is the most common musculoskeletal problem and the single most common cause of disability, often attributed to degeneration of the intervertebral disc. Lack of effective treatment is directly related to our limited understanding of the pathways responsible for maintaining disc health. While transcriptional analysis has permitted initial insights into the biology of the intervertebral disc, complete proteomic characterization is required. We therefore employed liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) protein/peptide separation and mass spectrometric analyses to characterize the protein content of intervertebral discs from skeletally mature wild-type mice. A total of 1360 proteins ...


Representatives Perales, Hackett Participate In Healthcare Forum, Mark D. Weinstein 2015 Cedarville University

Representatives Perales, Hackett Participate In Healthcare Forum, Mark D. Weinstein

News Releases

Cedarville University School of Pharmacy will host a policy forum on healthcare legislation with State Representatives Rick Perales and Bob Hackett along with Antonio Ciaccia, director of government and public affairs from the Ohio Pharmacist Association. The event, open to the public, will be held on Thursday, Feb. 5, in the Health Sciences Center in Room 107 beginning at 5:30 p.m.

This event will allow students to interact with representatives on legislative issues related to pharmacy. Currently the topics set in place for the forum are: student involvement, advocacy and communication with legislators, health care reform, Provider Status ...


Acid-Suppressing Agents And Risk For Clostridium Difficile Infection In Pediatric Patients, Katelyn E. Brown, Chad A. Knoderer, Kristen R. Nichols, Ashley S. Crumby 2015 Butler University

Acid-Suppressing Agents And Risk For Clostridium Difficile Infection In Pediatric Patients, Katelyn E. Brown, Chad A. Knoderer, Kristen R. Nichols, Ashley S. Crumby

Scholarship and Professional Work – COPHS

Background. Acid-suppressing agents have been associated with increased Clostridium difficile infection (CDI) in adults. The objective of this study was to evaluate the association of acid-suppressing therapy with the development of CDI in the pediatric population.

Methods. This was a retrospective case-control study. Children aged 1 through 17 years with a positive C difficile polymerase chain reaction (PCR) result obtained between June 1, 2008, and June 1, 2012, were randomly matched to a control population selected from patients with negative PCR.

Results. A total of 458 children were included. No difference was observed in acid-suppressive therapy prior to PCR in ...


Implementing Extended-Infusion Cefepime As Standard Of Care In A Children’S Hospital: A Prospective Descriptive Study, Kristen R. Nichols, Lauren C. Karmire, Elaine G. Cox, Michael B. Kays, Chad A. Knoderer 2015 Butler University

Implementing Extended-Infusion Cefepime As Standard Of Care In A Children’S Hospital: A Prospective Descriptive Study, Kristen R. Nichols, Lauren C. Karmire, Elaine G. Cox, Michael B. Kays, Chad A. Knoderer

Scholarship and Professional Work – COPHS

Background: Extended-infusion cefepime (EIC) has been associated with decreased mortality in adults, but to our knowledge, there are no studies in children.

Objective: The objective of this study was to determine the feasibility of implementing EIC as the standard dosing strategy in a pediatric population.

Methods: This was a descriptive study of children aged 1 month to 17 years, including patients in the intensive care unit, who received cefepime after admission to a freestanding, tertiary care children’s hospital. Patients were excluded if they were admitted to the neonatal intensive care unit or received cefepime in the outpatient, operating, or ...


Targeted Delivery Of Anti-Inflammatory And Anti-Oxidant Drugs For Treatment Of Chronic Obstructive Pulmonary Diseases, Yun Xiang 2015 Clemson University

Targeted Delivery Of Anti-Inflammatory And Anti-Oxidant Drugs For Treatment Of Chronic Obstructive Pulmonary Diseases, Yun Xiang

All Dissertations

Chronic obstructive pulmonary disease (COPD) was found to be the fourth leading cause of death in 2004, but current treatments can only relieve the symptoms and improve the quality of life for the patients. Glucocorticoids have been broadly applied in other inflammatory conditions with promising therapeutic effects, but performed poorly in COPD. The phenomenon called glucocorticoid resistance is responsible for glucocorticoid insensitivity in COPD. Researchers have proven that elevated oxidative stress in the lung of a COPD patient is one of the main causes of blocking the function of glucocorticoids. We hypothesize that reducing the oxidative stress in the lung ...


Elucidating The Mechanism Of Lipl: A Non-Heme Fe(Ii), Α -Ketoglutarate: Uridine-5’-Monophosphate Dioxygenase, Anwesha Goswami 2015 University of Kentucky

Elucidating The Mechanism Of Lipl: A Non-Heme Fe(Ii), Α -Ketoglutarate: Uridine-5’-Monophosphate Dioxygenase, Anwesha Goswami

Theses and Dissertations--Pharmacy

Several nucleoside natural product antibiotics from Streptomyces sp. and actinomycetes have recently been shown to target bacterial peptidoglycan cell wall biosynthesis by inhibiting the bacterial translocase I (MraY). The biosynthetic gene clusters for A-90289, liposidomycins and caprazamycins revealed a protein with sequence similarity to proteins annotated as α-KG:taurine dioxygenases (TauD). This enzyme (LipL) is a mononuclear, non-heme, Fe(II) dependent α-keto glutarate (α-KG) :uridine monophosphate (UMP) dioxygenase responsible for the net dephosphorylation and two electron oxidation of UMP to uridine-5’-aldehyde. The postulated reaction coordinates involving the activation of the C-5’ center in UMP and the corresponding formation of ...


Compliance To The Consort Statement On Participant Flow Diagrams In Infectious Disease Randomized Clinical Trials, Onyeka P. Godwin, Brandon Dyson, Paul S. Lee, Soon Park, Euni Lee 2015 Chapman University

Compliance To The Consort Statement On Participant Flow Diagrams In Infectious Disease Randomized Clinical Trials, Onyeka P. Godwin, Brandon Dyson, Paul S. Lee, Soon Park, Euni Lee

Pharmacy Faculty Articles and Research

Background: The Consolidated Standard of Reporting Trials (CONSORT) Guidelines were developed to support adequate reporting of randomized controlled trials (RCTs).

Method: A systematic review was conducted including RCTs of infectious diseases published in the top general medical and infectious disease journals in 2010. The level of compliance to flow diagram and its association with the CONSORT endorsement by the journals were evaluated.

Results: A total of 67 studies were included in the analysis and a half of the studies were HIV/AIDS RCTs. About 78% of the studies included the flow diagram and 66% of the studies described an intention-to-treat ...


Pharmacist Consult Service In Geriatric Trauma Patients, Vanessa M. Gleason, Pharm D., Rohit A. Moghe, Pharm D., MSPH, CDE, Doris Warner, MSN, RN, CEN, Michael S. Weinstein, MD, FACS 2014 Thomas Jefferson University

Pharmacist Consult Service In Geriatric Trauma Patients, Vanessa M. Gleason, Pharm D., Rohit A. Moghe, Pharm D., Msph, Cde, Doris Warner, Msn, Rn, Cen, Michael S. Weinstein, Md, Facs

Pharmacy, Presentations and Grand Rounds

Introduction

• Geriatric patients (> 65 years of age) have a 3-5% incremental increase in annual occurrence of trauma making it a top five leading cause of death in this population.

• The mortality rate ranges from 15-30%, which is 4-5 times higher than younger patients.

• In 2011, data from the Pennsylvania Trauma Systems Foundation (PTSF) demonstrated nearly 32% of injured patients statewide and nearly 50% of the trauma patients at Thomas Jefferson University Hospital (TJUH) were > 65 years.

• Most geriatric patients have comorbidities that are treated with many medications, which may predispose them for falls.

• Although there are many methods to assess ...


Retrospective Study To Identify Predictors Of Withdrawal In Pediatric Intensive Care Patients On Long-Term Sedation, Lindsay Fakete PharmD, Jenny Boucher PharmD, JD, BCPS, Scott Wheatley MD 2014 Lehigh Valley Health Network

Retrospective Study To Identify Predictors Of Withdrawal In Pediatric Intensive Care Patients On Long-Term Sedation, Lindsay Fakete Pharmd, Jenny Boucher Pharmd, Jd, Bcps, Scott Wheatley Md

Department of Pharmacy

No abstract provided.


Azithromycin Use In Upper Respiratory Infection, Charles D. Snyder, Sarah Winey, Scarlet Lau, Ryley Uber, Mouhannad Saad, Rebecca Widder, Douglas Anderson 2014 Cedarville University

Azithromycin Use In Upper Respiratory Infection, Charles D. Snyder, Sarah Winey, Scarlet Lau, Ryley Uber, Mouhannad Saad, Rebecca Widder, Douglas Anderson

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Antibiotic resistance is a problem that is growing worldwide. Misuse and overprescribing of antibiotics leads to a rise in pathogens that are resistant to the conventional drugs prescribed, causing increases in morbidity and mortality rates. Antibiotic resistance occurs when microbes still survive despite the presence of an antibiotic. The remaining microbes grow in strength and multiply until there is a population that are now resistant to treatment. One such treatment is azithromycin, an antibiotic often prescribed for upper respiratory tract infections (URI). A URI is any infection of the respiratory tract from the nasal cavities to the larynx that can ...


Assessing Student Empathy For Hemodialysis Patients, Stephanie M. Cailor, Logan Conkey, Laura K. Farleman, Rachel M. Wilcox, Emily M. Laswell 2014 Cedarville University

Assessing Student Empathy For Hemodialysis Patients, Stephanie M. Cailor, Logan Conkey, Laura K. Farleman, Rachel M. Wilcox, Emily M. Laswell

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Hemodialysis is a treatment process utilized by kidney patients to filter their blood. These patients are required to undergo an intensive regimen including hemodialysis treatments multiple times per week lasting 3-5 hours each. As a result of hemodialysis, patients experience decreased autonomy, freedom, and independence. An estimated 50% of these patients do not adhere to their treatment regimen. Patients on hemodialysis may be more compliant to their treatment if they are satisfied with the level of care and empathy they perceive from their healthcare providers. Currently there is no literature measuring empathy levels of healthcare professionals or students towards patients ...


Gmo Vs. Non-Gmo: Comparing The Addictiveness Of Corn In Rats, Sara L. Hill, Aric Carroll, Tyler Michael, Courtney Noll, Kelly A. Huston 2014 Cedarville University

Gmo Vs. Non-Gmo: Comparing The Addictiveness Of Corn In Rats, Sara L. Hill, Aric Carroll, Tyler Michael, Courtney Noll, Kelly A. Huston

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Genetically modified organisms (GMOs) refer to organisms whose DNA has been altered to produce a certain characteristic. GMOs account for a significant proportion of the crops produced in the United States. Specifically, GMO corn accounted for approximately 88% of all corn grown for human and animal consumption in the year 2012. Previously conducted studies have not uniformly demonstrated the safe use of GMO corn, and no studies have been conducted analyzing the addictiveness of GMO corn.

The idea of addiction refers to more than just a physical dependence, but to a psychological dependence on something as well. It is sometimes ...


Medication Reconciliation Of Medically-Complex Emergency Department Patients By Second-Year Professional Pharmacy Students, Lauren Haines, Neal S. Fox, Rachel Bull, Jeb Ballentine, Zachary Jenkins 2014 Cedarville University

Medication Reconciliation Of Medically-Complex Emergency Department Patients By Second-Year Professional Pharmacy Students, Lauren Haines, Neal S. Fox, Rachel Bull, Jeb Ballentine, Zachary Jenkins

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

ABSTRACT:

Background: There is a high potential for medication discrepancies to occur during patient care transitions. However, health professionals must find ways to reduce these and improve patient care, such as with medication reconciliation. This intervention is used to identify a patient’s most accurate medication list by comparing the medical record to another list obtained from the patient, hospital, or other provider. Pharmacists have a major role in this process because of their medicinal expertise, but paying them is expensive, so using students may be more cost-effective. Research has examined fourth-year professional pharmacy students (P4s) performing medication reconciliation during ...


A Measure Of The Amount Of Vitamin K Leached Out From Cooked Greens In Potlicker, Douglas Anderson, Kara Bobka, Matthew Johnson, Chelsea Manion, Samuel Tesfaye, Rebecca Widder, Joshua Willoughby 2014 Cedarville University

A Measure Of The Amount Of Vitamin K Leached Out From Cooked Greens In Potlicker, Douglas Anderson, Kara Bobka, Matthew Johnson, Chelsea Manion, Samuel Tesfaye, Rebecca Widder, Joshua Willoughby

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Vitamin K, a fat-soluble vitamin synthesized by plants, is found in large quantities within green leafy vegetables, such as collard, mustard, turnip and spinach. These greens are commonly cooked with fat to enhance flavor. The vitamin K in these greens can leach out during cooking into the liquid portion of the pot, which is referred to as potlicker. Vitamin K activates clotting factors (II, VII, IX, and X,), which can lead to the formation of a thromboembolism (blood clot). People at a higher risk of forming blood clots are often prescribed warfarin, an anti-coagulant that acts as a competitive inhibitor ...


Assessing Patient Adherence And Satisfaction: Clinical Services Beyond The Pharmacy Counter, Thaddeus Franz, Bryan Feldmann, Colin J. Behm, Danielle Grear, Jeremy Flikkema 2014 Cedarville University

Assessing Patient Adherence And Satisfaction: Clinical Services Beyond The Pharmacy Counter, Thaddeus Franz, Bryan Feldmann, Colin J. Behm, Danielle Grear, Jeremy Flikkema

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Medication adherence is a bigger problem than many of us are willing to admit. If patients do not take their medications as prescribed, they will not get the full therapeutic benefits and will put themselves at risk if serious harm. An estimated 125,000 deaths occur in the United States annually due to non-adherence. The objective of this study is to establish a pharmacy intervention model that best provides patient satisfaction and improved medication adherence through the use of home visits and follow-up calls by pharmacists and pharmacy interns at Clark’s Pharmacy. In order to do this, patients receiving ...


Community Education On Mtm Services, Kristin Lessig, Lindsay Mailloux, Jacob Davis, Samantha Smolinski, Stephen Yeboah, Aleda Chen, Thaddeus Franz, Ginger Cameron, Jenna Lawhead 2014 Cedarville University

Community Education On Mtm Services, Kristin Lessig, Lindsay Mailloux, Jacob Davis, Samantha Smolinski, Stephen Yeboah, Aleda Chen, Thaddeus Franz, Ginger Cameron, Jenna Lawhead

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Abstract

Background

Medication nonadherence, defined as “the number of doses not taken or taken incorrectly that jeopardizes the patient’s therapeutic outcome,” is a major health problem with about 43% of the general population nonadherent to their medications. Medication nonadherence accounts for an estimated 125,000 deaths per year in the US, 33-69% of medication-related hospital readmissions, and an estimated $100 to $300 billion in direct and indirect medical costs. Medication therapy management (MTM), defined as “a distinct service or group of services that optimize therapeutic outcomes for individual patients,” has been found to reduce medication nonadherence. However, many individuals ...


Pharmaceutical Stability Of Promethazine In Iv Infusion Fluids, Josh Knoebel, Ruth Choi, Michael Kapraly, Brandon Kime, Kaysie J. Brittenham, Denise S. Simpson, Rebecca J. Gryka, Samson Amos 2014 Cedarville University

Pharmaceutical Stability Of Promethazine In Iv Infusion Fluids, Josh Knoebel, Ruth Choi, Michael Kapraly, Brandon Kime, Kaysie J. Brittenham, Denise S. Simpson, Rebecca J. Gryka, Samson Amos

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

BACKGROUND: Promethazine is an antiemetic often administered intravenously in healthcare facilities for postoperative nausea and vomiting. Due to potential adverse events that may result with intravenous push administration, some safety-minded healthcare facilities have elected to use alternative methods of administration. One such method is the intravenous piggyback (IVPB). However, limited stability data exist for promethazine in intravenous solutions.

OBJECTIVE: To analyze the stability over time of promethazine dissolved in commonly used intravenous infusion fluids when exposed to various light and temperature conditions.

PROPOSED METHODS: Promethazine will be formulated into IVPB bags of normal saline, dextrose 5% in water and Lactated ...


Redesign Of Trans-Splicing Molecules For The Correction Of Dystrophia Myotonica Type 1 Toxic Rna Transcripts, Eleanor G. Harrison 2014 East Tennessee State University

Redesign Of Trans-Splicing Molecules For The Correction Of Dystrophia Myotonica Type 1 Toxic Rna Transcripts, Eleanor G. Harrison

Undergraduate Honors Theses

Dystrophia myotonica (DM1), one of the most common forms of muscular dystrophy, is caused by a repeated trinucleotide expansion in the DMPK gene. This mutation results in the accumulation of toxic cellular RNA transcripts. Spliceosome-mediated RNA trans-splicing (SMaRT) technology is a form of gene therapy that possesses the potential to correct these toxic RNA transcripts and thus cure the disease. Despite its promise, prior research applications of SMaRT technology to DM1 have been hampered by poor efficiency and have not been validated in a relevant model of the disease. In order to improve the efficiency of trans-splicing, this study examined ...


Formulation And Stability Of An Extemporaneously Compounded Oral Solution Of Chlorpromazine Hcl, Daniel L. Prohotsky, Katherine Juba, Fang Zhao 2014 St. John Fisher College

Formulation And Stability Of An Extemporaneously Compounded Oral Solution Of Chlorpromazine Hcl, Daniel L. Prohotsky, Katherine Juba, Fang Zhao

Pharmacy Faculty Publications

Chlorpromazine is a phenothiazine antipsychotic which is often used in hospice and palliative care to treat hiccups, delirium, and nausea. With the discontinuation of the commercial oral solution concentrate, there is a need to prepare this product by extemporaneous compounding. This study was initiated to identify an easy-to-prepare formulation for the compounding pharmacist. A stability study was also conducted to select the proper storage conditions and establish the beyond-use date. Chlorpromazine HCl powder and the Ora-Sweet® syrup vehicle were used to prepare the 100 mg/mL solution. Once the feasibility was established, a batch of the solution was prepared and ...


Digital Commons powered by bepress