Design, Synthesis, And Evaluation Of Novel Positron Emission Tomography Radiotracers, 2017 University of Tennessee Health Science Center
Design, Synthesis, And Evaluation Of Novel Positron Emission Tomography Radiotracers, Christopher Philip Surdock
Theses and Dissertations (ETD)
Neuroblastoma (NB) is the most common extracranial tumor in patients under 1 year of age and it constitutes about 8-10% of all childhood cancer. It originates from neural crest cells that normally differentiate to form the sympathetic ganglia, adrenal medulla and other paraspinal sites where sympathetic nervous system tissue is present. Even with an extensive treatment regimen that typically includes surgery, chemotherapy, total body irradiation and autologous stem cell transplantation, the 5-year event-free survival is <50% for high risk patients, and there are numerous long-term side effects associated with treatment. This body of work investigated two projects for improving patient outcomes through the development of positron emission tomography (PET) radiotracers that could be used for therapy planning. The goal of the first project was to design, synthesize, and evaluate PET radiotracers that could measure the enzymatic activation of Irinotecan (CPT-11), a potent chemotherapeutic used in the treatment of colon cancer and several pediatric solid tumors. CPT-11 itself is a prodrug which is converted in vivo to SN-38, via metabolism by carboxylesterase (CE) enzymes. St. Jude Children’s Research Hospital researchers have designed a two-pronged protocol of tumor-targeted CPT-11 chemotherapy combining the complementary approaches of a) specific modulation of human CE in normal tissues to improve drug delivery, and b) tumor-targeted activation of prodrug using neural progenitor cells (NPC) transfected with a mutant human CE cDNA. The tumor-selective trafficking of NPC allows over-expression of CE within the tumor. This prodrug/activating enzyme therapeutic approach has shown extremely encouraging preclinical results in the treatment of NB (90% 1-year survival in mice). However, successful translation of this novel therapeutic approach into general clinical practice requires a better understanding of progenitor cell trafficking, duration and intensity of enzymatic activity and the ultimate biological fate of the therapeutic construct. Toward this end, PET radiotracers were developed based on extensive structure-activity relationship (SAR) studies of CE binding. The goal of the second project was to design, synthesize, and evaluate PET radiotracers that could identify the presence of the tropomyosin receptor kinase B (TrkB). TrkB is not normally found in sympathetic nervous tissue, which is the tissue NB develops from, and thus is a potential target for imaging and therapy. The presence of TrkB and its neurotrophin, brain derived neurotrophic factor (BDNF), have been reported to protect neuroblastoma tumor cells from chemotherapy-induced apoptosis via a phosphatidylinositol 3’-kinase pathway. Radiotracers were synthesized and evaluated for their ability to identify TrkB both in vitro and in vivo. PET radiosynthetic procedures were optimized to synthesize novel radiotracers for imaging targets that could help clinicians monitor therapy or identify markers that would aid in therapy planning for NB patients. The method development could be applied to future compounds that show improved chemical characteristics for synthesis and selectivity.
Improving Medication Use For Project Home Residents In An Urban Setting, 2017 Thomas Jefferson University
Improving Medication Use For Project Home Residents In An Urban Setting, Toni Campanella, Pharmd Candidate, Ashley Maister, Pharmd Candidate, Roshni S. Patel, Pharmd, Bcps
Jefferson College of Pharmacy Posters
Project HOME is a non-profit organization in Philadelphia that provides housing, employment opportunities, medical care, and education to those who are homeless or at risk of becoming homeless, including those with a history of serious mental health or substance misuse disorders.
Jefferson College of Pharmacy students are dedicated to transforming the health and well-being of the community. By engaging in innovative opportunities, students are well-positioned to deliver patient-centered care.
APhA-ASP serves as the collective voice of student pharmacists to provide opportunities for professional growth, to improve patient care, and to envision and advance the future of pharmacy.
Pharmart: The Art Of Bringing Faculty, Librarians, And Students Together, 2017 University of the Pacific
Pharmart: The Art Of Bringing Faculty, Librarians, And Students Together, Mickel Paris, Edward L. Rogan, R. Stark, Cassie Etter, Kate Dopkins
No abstract provided.
Mono Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acetylcholine Receptors, 2017 University of Kentucky
Mono Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acetylcholine Receptors, Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Zhenfa Zheng
Pharmaceutical Sciences Faculty Patents
Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
How Can Pharmacists Develop Patient-Pharmacist Communication Skills? A Realist Review Protocol., 2017 Royal College of Surgeons in Ireland
How Can Pharmacists Develop Patient-Pharmacist Communication Skills? A Realist Review Protocol., Aisling Kerr, Judith Strawbridge, Caroline Kelleher, Fien Mertens, Peter Pype, Myriam Deveugele, Teresa Pawlikowska
School of Pharmacy Articles
BACKGROUND: Good patient-pharmacist communication improves health outcomes. There is, however, room for improving pharmacists' communication skills. These develop through complex interactions during undergraduate pharmacy education, practice-based learning and continuing professional development. Research is needed to determine how best to approach teaching patient-pharmacist communication.
METHODS: The aim of the research is to understand how educational interventions develop patient-pharmacist interpersonal communication skills produce their effects. A realist review approach will be used to synthesise the literature to make sense of the complexities of educational interventions. Our review will iteratively progress through the various stages of clarifying scope, locating existing theories, searching for ...
Bis-Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acetylcholine Receptors, 2017 University of Kentucky
Bis-Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acetylcholine Receptors, Peter A. Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran
Pharmaceutical Sciences Faculty Patents
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
Reflections From The Bedsides Of Dying Patients, 2017 Jefferson College of Pharmacy 2019
Reflections From The Bedsides Of Dying Patients, Hannah Decleene, Patrick Kukulich
Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)
I walked into a room with its lights glaring and television blaring, a room where a man I had never met before would take his final breath two hours later. The attending nurse kindly dimmed the lights and turned off the television. I sat down next to him. I felt panic. I felt sadness, and I felt peace. This individual would have passed without me knowing, yet I was there with him; he wouldn’t be alone.
The No One Dies Alone (NODA) chapter at Jefferson launched in May, 2016. It launched as a vision in which students of Thomas ...
Sesquiterpene Synthase Gene And Protein, 2017 University of Kentucky
Sesquiterpene Synthase Gene And Protein, Joseph Chappell, Bryan T. Greenhagen
Pharmaceutical Sciences Faculty Patents
The invention relates to sesquiterpene synthases and methods for their production and use. Particularly, the invention provides nucleic acids comprising the nucleotide sequence of citrus valencene synthase (CVS) which codes for at least one CVS. The invention further provides nucleic acids comprising the nucleotide sequence coding for amino acid residues forming the tier 1 and tier 2 domains of CVS. The invention also provides for methods of making and using the nucleic acids and amino acids of the current invention.
Using A Tailored Health Information Technology Driven Intervention To Improve Health Literacy And Medication Adherence (Talkingrx), Brenda Fay
Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi
Mahendra Kumar Trivedi
Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi, Dahryn Trivedi
Mahendra Kumar Trivedi
The Effects Orthostatic Hypotension Has On Falls: A Study Done In San Francisco With The Patient Population Of The Veterans Affairs Hospital, Sherry A. Ballard Ms.
The Effects Orthostatic Hypotension has on Falls: A Study Done in San Francisco Represented
Population of the Veterans Affairs Hoapital
The global AIM of this project is to Identify patients that are at risk for Orthostatic Hypotension (OH) with in the first 24 hours of addmission. It was identified that 50% of the falls over the last 4 quarters at the VA were OH related. The patients were not identified as a fall risk and over half of them had fallen multiple times. After performing a nursing survey online, a SWOT analysis, and a Root Cause Analysis using a fishbone ...
Development Of Cxcr4-Inhibiting Nanoparticles For The Treatment Of Metastatic Cancer, 2016 University of Nebraska Medical Center
Development Of Cxcr4-Inhibiting Nanoparticles For The Treatment Of Metastatic Cancer, Yan Wang
Theses & Dissertations
Metastasis is the main cause of cancer mortality and morbidity, leading to several million deaths every year. Less than 20% of pancreatic cancer (PC) patients are candidates for surgery due to spread beyond the pancreas. Desmoplasia presents substantial barriers to perfusion, diffusion, and convection of antitumor therapeutics into the PC tissues. We focus on developing novel therapies that regulates tumor microenvironment, chemosensitizing tumor to therapeutics and preventing metastasis.
Gene therapy is emerging as a promising new therapeutic agents for cancer treatment. A targeted, systemic, effective and safe gene delivery system should be developed. CXCR4/SDF-1 axis plays a crucial role ...
A Delphi Process To Address Medication Appropriateness For Older Persons With Multiple Chronic Conditions, Terri R. Fried, Kristina Niehoff, Jennifer Tjia, Nancy Redeker, Mary K. Goldstein
BACKGROUND: Frameworks exist to evaluate the appropriateness of medication regimens for older patients with multiple medical conditions (MCCs). Less is known about how to translate the concepts of the frameworks into specific strategies to identify and remediate inappropriate regimens.
METHODS: Modified Delphi method involving iterative rounds of input from panel members. Panelists (n = 9) represented the disciplines of nursing, medicine and pharmacy. Included among the physicians were two geriatricians, one general internist, one family practitioner, one cardiologist and two nephrologists. They participated in 3 rounds of web-based anonymous surveys.
RESULTS: The panel reached consensus on a set of markers to ...
Inhibition Of Major Integrin Αvβ3 Reduces Staphylococcus Aureus Attachment To Sheared Human Endothelial Cells., 2016 Royal College of Surgeons in Ireland
Inhibition Of Major Integrin Αvβ3 Reduces Staphylococcus Aureus Attachment To Sheared Human Endothelial Cells., Cormac J. Mcdonnell, Carolina D. Garciarena, Rebecca L. Watkin, Tony M. Mchale, Alisha Mcloughlin, Jorien Claes, Peter Verhamme, Philip M. Cummins, Steven W. Kerrigan
School of Pharmacy Articles
BACKGROUND: Vascular endothelial dysfunction with associated oedema and organ failure is one of the hallmarks of sepsis. While a large number of microorganisms can cause sepsis, Staphylococcus aureus is one of the primary etiological agents. Currently there are no approved specific treatments for sepsis and therefore the initial management bundle focuses on cardiorespiratory resuscitation and mitigation against the immediate threat of uncontrolled infection. The continuous emergence of antibiotic resistant strains of bacteria urges the development of new therapeutic approaches for this disease.
OBJECTIVE: The objective of this study was to identify the molecular mechanisms leading to endothelial dysfunction as a ...
Implementation Of Community Pharmacy Dispensing Software (Mydispense) In An Advanced Pharmacy Practice Course, 2016 University of Kentucky
Implementation Of Community Pharmacy Dispensing Software (Mydispense) In An Advanced Pharmacy Practice Course, Clark Kebodeaux, Keith Sewell
Objectives: MyDispense is an interactive community pharmacy simulation program designed to build students’ confidence related to community pharmacy practice. MyDispense was implemented in the Advanced Pharmacy Practice course at St. Louis College of Pharmacy during the P3 year as an activity and assessment for competency in the community pharmacy setting. In order to make future curriculum improvements, the objective of this study is to evaluate the usefulness and applicability of the MyDispense program into a required course.
Method: The study will consist of an anonymous online survey available to students in the Advanced Pharmacy Practice course for two weeks following ...
Student Perception Of The Impact Of Audience Response Software In A Team-Based Learning Self-Care Course, 2016 University of Kentucky
Student Perception Of The Impact Of Audience Response Software In A Team-Based Learning Self-Care Course, Clark Kebodeaux, Leslie Woodyard, Golden Peters, Patrick Finnegan
Objectives: Evidence evaluating audience response systems (ARS) used in team-based learning (TBL) compared to traditional classes is limited. The objectives of this study are to evaluate student perceptions of the technology and compare students’ assessment of technology with their performance. Method: TBL was implemented in the required self-care course (PP2120: Introduction to Pharmaceutical Care: Non-prescription drugs) at St. Louis College of Pharmacy, and an audience response system was implemented in Fall 2015. At the conclusion of the course, a web-based survey was administered to students. Results: Of the 29 students who successfully completed the course, 23 (79%) completed the survey ...
Chain Community Pharmacists' Willingness, Attitudes, And Barriers In Providing Self-Care Medication And Supplement Recommendations, Clark Kebodeaux, William M. Grise, Brooke Hudspeth, Holly Divine
BACKGROUND: Pharmacists are commonly called on as the first resource for patients when selecting an appropriate self-care medication or supplement. This study examines pharmacists’ over-the-counter (OTC) recommendations in the chain community pharmacy setting in the United States.
OBJECTIVES: The objective of the study was to assess chain community pharmacists’ willingness and attitudes to provide self-care recommendations to patients and to identify chain community pharmacists’ barriers to making OTC medication and supplement recommendations.
METHODS: An anonymous survey was created to identify pharmacists’ attitudes and their willingness to perform these recommendations. The questionnaire included specific questions to identify barriers that exist to ...
Book Review Of Baruch A. Brody, Ethical Issues In Drug Testing, Approval, And Pricing, 2016 University of New Hampshire
Book Review Of Baruch A. Brody, Ethical Issues In Drug Testing, Approval, And Pricing, Annalee Abelson
RISK: Health, Safety & Environment
Review of Baruch A. Brody, Ethical Issues in Drug Testing, Approval, and Pricing (Oxford University Press 1995). Conclusions, index, introduction, preface. LC 94-4479; ISBN 0-19-508831-X. [268 pp. Cloth $35.00. 200 Madison Avenue, New York NY 10016.]
Differences In Amphetamine/Dextroamphetamine Prescriptions In Areas With & Without Large Universities, 2016 Western Michigan University
Differences In Amphetamine/Dextroamphetamine Prescriptions In Areas With & Without Large Universities, Heather Bacon
This investigative study is examining trends in stimulant prescribing for several Michigan counties. An ex-post facto design was used to determine trends in the amount of amphetamine/dextroamphetamine dispensed in four Michigan counties containing large universities and two Michigan counties not containing large universities over the years 2007-2012. The study found suggestive evidence that there is an increasing trend of amphetamine/dextroamphetamine prescriptions filled in both counties with and without large universities. Suggestive evidence was also found that counties with large universities display a greater average amount of amphetamine/dextroamphetamine dispensed than counties without large universities for the years 2007-2012 ...