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Compulsory Licenses: Damaging Firm Value In The Short Run?, Daniel E. Mansuri Mr. 2015 Bates College

Compulsory Licenses: Damaging Firm Value In The Short Run?, Daniel E. Mansuri Mr.

Honors Theses

While very few individuals question the validity and necessity of the patent system, the temporary monopolies imposed by patents necessarily reduce access to medication. This becomes especially problematic when dealing with issues of public ordre, such as the aids crisis in the last 30 years. Compulsory licensing, or the power for a government to void a patent and allow a non-patent holder to produce a patented good, aims to remedy this problem. Governments have the ability to issue these in times of epidemics, or other issues of rampant illness. However, even though these licenses are completely legal, pharmaceutical companies meet ...


Analyzation Of Metabolic Reprogramming In Drug-Resistant Mcf-7 Cells, Derick Han, Ho Leung, Andrew Vo 2015 Keck Graduate Institute

Analyzation Of Metabolic Reprogramming In Drug-Resistant Mcf-7 Cells, Derick Han, Ho Leung, Andrew Vo

Student Research Day Abstracts and Posters

The Warburg effect states that cancer cells mainly receive their energy from anaerobic glycolysis. Thus, mitochondria play a different role in the metabolism of cancer cells as opposed to normal, healthy cells. In chemotherapy, there is always a chance of the cancer regressing. Making drug-resistant cancer cells to analyze their metabolism may change how cancer is treated. This study aimed to create drug-resistant MCF-7 cell lines with doxorubicin in order to determine the metabolic changes that have occurred in the process of becoming resistant to drug treatments.


Clinical Applications Of A Combination Chemotherapy Using 8-Chloro Camp And 8-Chloro Adenosine, Erik Munoz, Andrea Saich, Andrew Cox, Yu-An Peter Chang 2015 Chapman University

Clinical Applications Of A Combination Chemotherapy Using 8-Chloro Camp And 8-Chloro Adenosine, Erik Munoz, Andrea Saich, Andrew Cox, Yu-An Peter Chang

Student Research Day Abstracts and Posters

Dr. Cho-Chung from the NIH first thought to use halogenated cAMP derivatives as competitive inhibitors of cAMP to slow down cancer cell mitosis. While the iodine and bromine substituted versions showed very little therapeutic actions, 8-Chloro cAMP has been shown to have strong anti-cancer effects. This has been shown in the phase II clinical trials this drug has undergone. However, these trials have had issues with solubility and toxicity. The drug is similar to vitamin C and is excreted quickly. Scientists tried to overcome this by using a peristaltic pump to give patients a continuous dosage, but this proved too ...


Argatroban For The Treatment Of Heparin-Induced Thrombocytopenia In End Stage Renal Disease And Acute Kidney Injury, Lindsey Elmore PharmD, BCPS, Leslie A. Hamilton Pharm.D., BCPS 2015 University of Tennessee Health Science Center

Argatroban For The Treatment Of Heparin-Induced Thrombocytopenia In End Stage Renal Disease And Acute Kidney Injury, Lindsey Elmore Pharmd, Bcps, Leslie A. Hamilton Pharm.D., Bcps

Tennessee Medicine E-Journal

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Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, Sneha Shah 2015 Virginia Commonwealth University

Risperidone And Its Deconstructed Analogs: Functional Effects On The 5ht2ar, Sneha Shah

Sneha Shah

G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways. The serotonin 5HT2A receptor (or 2AR) is one of the GPCRs coupled to Gq proteins, activating PLC and hydrolyzing PIP2. This hydrolysis causes a diffusion of bound PIP2 away from the channel binding site resulting in G protein-gated inwardly rectifying K+ channel (GIRK) inhibition and a downstream stimulation of Ca2+ release from endoplasmic reticulum stores. Previous experiments have demonstrated that the serotonin 5HTA receptor is a target of serotonergic psychedelic drugs, such as LSD, and partially mediates the action of many atypical antipsychotic ...


Periodontal Disease: Molecular Visualization Through Computer Modeling And 3d Printing, Catherine Chatowsky 2015 University of Rhode Island

Periodontal Disease: Molecular Visualization Through Computer Modeling And 3d Printing, Catherine Chatowsky

Senior Honors Projects

Periodontal disease is a common infection that damages gingival tissue and creates jawbone destruction that can lead to the loosening or loss of teeth. Hundreds of diverse bacterial species reside in the harsh environment of the oral cavity. The creation of plaque and biofilms serve to allow the bacteria to avoid immune-mediated destruction. This project analyzed periodontal disease pathogens using molecular printing 3D visualization. Two bacterial species (T. denticola and P. gingivalis) were chosen from the public resource: Research Collaboratory for Structural Bioinformatics: Protein Data Bank. T. denticola was a bacteria found to have a binding protein (FhbB) that structurally ...


The Effects Of Rhein And Thymoquinone On Obesity And Diabetes In Diet-Induced Obese Mice., Emily Martell 2015 University of Rhode ISland

The Effects Of Rhein And Thymoquinone On Obesity And Diabetes In Diet-Induced Obese Mice., Emily Martell

Senior Honors Projects

Natural product extracts and chemicals isolated from natural products (e.g. plants, berries, seeds) have been commonly used in various types of traditional medicines. In addition, some drugs on the market today have been derived from natural product sources. The purpose of our study was to evaluate two natural products, Rhein and Thymoquinone, for as potential anti-diabetic and anti–obesity agents. According to the Center for Disease Control (CDC), the number of people in the US diagnosed with diabetes has increase from 11.9 million people in the year 2000 to 20.8 million people in the year 2011. Rhein ...


An Information Privacy Examination Of The Practices Of Pharmaceutical Companies Regarding Use Of Information Collected Through Their Websites, Shonda Dellena Brown 2015 Nova Southeastern University

An Information Privacy Examination Of The Practices Of Pharmaceutical Companies Regarding Use Of Information Collected Through Their Websites, Shonda Dellena Brown

GSCIS ETDs

Consumers have begun to take a more proactive approach to their healthcare by accessing pharmaceutical companies Websites to obtain health and drug information, support groups, rebates, coupons, as well as free drug trials. In exchange for these benefits, companies require consumers to voluntarily disclose information. However, research has shown that consumers continue to be concerned about how their information is managed, used, and distributed by companies, especially if accessed via the Web. To date, there has been limited empirical research to examine the actual online practices of companies when it comes to privacy, especially those of pharmaceutical companies. Using Delphi ...


Interactive Web-Based Learning Modules Prior To General Medicine Advanced Pharmacy Practice Experiences, Alex N. Isaacs, Alison M. Walton, Sarah A. Nisly 2015 Purdue University

Interactive Web-Based Learning Modules Prior To General Medicine Advanced Pharmacy Practice Experiences, Alex N. Isaacs, Alison M. Walton, Sarah A. Nisly

Scholarship and Professional Work – COPHS

Objective. To implement and evaluate interactive web-based learning modules prior to advanced pharmacy practice experiences (APPEs) on inpatient general medicine.

Design. Three clinical web-based learning modules were developed for use prior to APPEs in 4 health care systems. The aim of the interactive modules was to strengthen baseline clinical knowledge before the APPE to enable the application of learned material through the delivery of patient care.

Assessment. For the primary endpoint, postassessment scores increased overall and for each individual module compared to preassessment scores. Postassessment scores were similar among the health care systems. The survey demonstrated positive student perceptions of ...


Improving Healthcare Outcomes Through An Interdisciplinary Effort Of Social Work And Pharmacy In A “Village” Model Setting, Elizabeth Hipp, Lauren Post 2015 Ohio State University - Main Campus

Improving Healthcare Outcomes Through An Interdisciplinary Effort Of Social Work And Pharmacy In A “Village” Model Setting, Elizabeth Hipp, Lauren Post

Ohio Association of Gerontology and Education Conference

OAGE is an association of educators, researchers, professionals, and students in Ohio dedicated to gerontological education, research and practice. The organization promotes gerontological education, supports Ohio's aging network as a resource for research and practice, and provides professional development for students, faculty and professionals.

OAGE is committed to maintaining close working relationships with the Ohio Department of Aging, the Ohio Area Agencies on Aging, Ohio's post secondary institutions, and all professional organizations and individuals in the aging network.


Obafluorin: A Potential Inhibitor Of Serine Hydroxymethyl Trasferase, Neha Prasad 2015 Washington University in St Louis

Obafluorin: A Potential Inhibitor Of Serine Hydroxymethyl Trasferase, Neha Prasad

Undergraduate Research Symposium Posters & Abstracts

In the golden age of drug discovery, scientists turned to nature to find and emulate molecules with pharmacological activity. The beta-lactam ring in penicillin has proven to be one of the most important classes of antibiotics of the last century. The molecule I am studying, obafluorine, was isolated from Pseudomonas fluorescens and has a beta-lactone ring in its structure—a close relative of the beta-lactam ring in Penicillin. Obafluorin was isolated as a broad-spectrum antibacterial and antifungal agent that could have therapeutic properties, but its cellular target is still unknown. The Wencewicz Lab in the WUSTL Department of Chemistry is ...


Polymeric Nanoparticle-Based Delivery Of Microrna-199a-3p Inhibits Proliferation And Growth Of Osteosarcoma Cells, Linlin Zhang, Arun K. Iyer, Xiaoqian Yang, Eisuke Kobayashi, Yuqi Guo, Henry Mankin, Francis J. Hornicek, Mansoor M. Amiji, Zhenfeng Duan 2015 Massachusetts General Hospital

Polymeric Nanoparticle-Based Delivery Of Microrna-199a-3p Inhibits Proliferation And Growth Of Osteosarcoma Cells, Linlin Zhang, Arun K. Iyer, Xiaoqian Yang, Eisuke Kobayashi, Yuqi Guo, Henry Mankin, Francis J. Hornicek, Mansoor M. Amiji, Zhenfeng Duan

Pharmaceutical Sciences Faculty Publications

Our prior screening of microRNAs (miRs) identified that miR-199a-3p expression is reduced in osteosarcoma cells, one of the most common types of bone tumor. miR-199a-3p exhibited functions of tumor cell growth inhibition, suggesting the potential application of miR-199a-3p as an anticancer agent. In the study reported here, we designed and developed a lipid-modified dextran-based polymeric nanoparticle platform for encapsulation of miRs, and determined the efficiency and efficacy of delivering miR-199a-3p into osteosarcoma cells. In addition, another potent miR, let-7a, which also displayed tumor suppressive ability, was selected as a candidate miR for evaluation. Fluorescence microscopy studies and real-time polymerase chain ...


Exploration Of Putative Mitochondrial Gene Expression In Crithidia Fasciculata As A Model For Pathogenic Trypanosomes Causing Human Disease, Baylye Boxall, Nadjean Sagesse 2015 Georgia State University

Exploration Of Putative Mitochondrial Gene Expression In Crithidia Fasciculata As A Model For Pathogenic Trypanosomes Causing Human Disease, Baylye Boxall, Nadjean Sagesse

Georgia State Undergraduate Research Conference

No abstract provided.


Filamin A Phosphorylation By Akt Promotes Cell Migration In Response To Arsenic, Lingzhi LI, Yongju Lu, Paul M. Stemmer, Fei Chen 2015 Wayne State University

Filamin A Phosphorylation By Akt Promotes Cell Migration In Response To Arsenic, Lingzhi Li, Yongju Lu, Paul M. Stemmer, Fei Chen

Pharmaceutical Sciences Faculty Publications

We had previously reported that trivalent arsenic (As3+), a well-known environmental carcinogen, induces phosphorylation of several putative Akt substrates. In the present report, we characterized one of these substrates by immunoprecipitation and proteomics analysis. The results indicate that a cytoskeleton remodeling protein, filamin A, with a molecular weight around 280 kDa, is phosphorylated by Akt in HEK-293 cells treated with As3+, which was also confirmed in human bronchial epithelial cell line, BEAS-2B cells. Additional biochemical and biological studies revealed that serine 2152 (S2152) of filamin A is phosphorylated by activated Akt in the cells treated with As3+. To ...


2015 Symposium Overview, Cedarville University 2015 Cedarville University

2015 Symposium Overview, Cedarville University

The Research and Scholarship Symposium

Click the "Download" button in the top right corner to view the abstract booklet.


Simulation-Based Interdisciplinary Team Learning—Pilot Study, Brian C. Patterson, Adam H. Altman, Brittani H. Purkeypile, Bethany Sibbitt, Zachary IlGiovine, Nicholaus Christian, Phillip J. Wenzell, Natasha Mehta, Raymond Ten Eyck 2015 Wright State University

Simulation-Based Interdisciplinary Team Learning—Pilot Study, Brian C. Patterson, Adam H. Altman, Brittani H. Purkeypile, Bethany Sibbitt, Zachary Ilgiovine, Nicholaus Christian, Phillip J. Wenzell, Natasha Mehta, Raymond Ten Eyck

The Research and Scholarship Symposium

Background: Currently, interprofessional education (IPE) is becoming widely integrated into healthcare professional education with regulating bodies including IPE as a curricular requirement. Although recent studies have concluded that students value IPE, there are a number of challenges associated with initial engagement. Many schools are unsure how to approach this interdisciplinary integration. In addition to IPE, simulation has become an important tool in the education of health professionals. As the first exercise at Wright State University involving interprofessional groups composed completely of undergraduates, interested students from the Boonshoft School of Medicine, the WSU College of Nursing and Health, and the Cedarville ...


Cilia Have A Significant Role In Regulating Cell Size In Response To Fluid Flow Induced Shear Stress In A Flow Chamber, Ryan M. Hecklinger, Schuyler E. Price, Matthew B. Welkie Jr., Timothy L. Norman, Elisha R. Injeti 2015 Cedarville University

Cilia Have A Significant Role In Regulating Cell Size In Response To Fluid Flow Induced Shear Stress In A Flow Chamber, Ryan M. Hecklinger, Schuyler E. Price, Matthew B. Welkie Jr., Timothy L. Norman, Elisha R. Injeti

The Research and Scholarship Symposium

Cilia are hair-like protrusions on the apical surface of cells. Their function is to relay mechanical signals like shear stress from extracellular into intracellular environment and thereby maintain cellular homeostasis. Ciliary dysfunctions include polycystic kidney disease and new therapeutic interventions based on ciliary function are under investigation. The current study evaluates the use of a custom designed fluid flow chamber’s ability to study the role of cilia in regulating cell size in response to shear stress.

A fluid flow chamber that continually maintains laminar flow at different flow rates and temperature was designed. Endothelial wild type cells (ETWT) that ...


Medication Reconciliation Of Medically-Complex Emergency Department Patients By Second-Year Professional Pharmacy Students, Lauren Haines, Neal S. Fox, Rachel R. Bull, Jeb Ballentine, Thaddeus T. Franz, Zachary N. Jenkins 2015 Cedarville University

Medication Reconciliation Of Medically-Complex Emergency Department Patients By Second-Year Professional Pharmacy Students, Lauren Haines, Neal S. Fox, Rachel R. Bull, Jeb Ballentine, Thaddeus T. Franz, Zachary N. Jenkins

The Research and Scholarship Symposium

Background: There is a high potential for medication discrepancies to occur during patient care transitions. However, health professionals must find ways to reduce these and improve patient care, such as with medication reconciliation. This intervention is used to identify a patient’s most accurate medication list by comparing the medical record to another list obtained from the patient, hospital, or other provider. Pharmacists have a major role in this process because of their medicinal expertise, but paying them is expensive, so using students may be more cost-effective. Research has examined fourth-year professional pharmacy students (P4s) performing medication reconciliation during their ...


Gmo Vs. Non-Gmo: Comparing The Addictiveness Of Corn In Rats, Christian A. Carroll, Sara L. Hill, Kelly A. Huston, Tyler Michael, Courtney Noll, Melissa J. Beck, Ginger Cameron 2015 Cedarville University

Gmo Vs. Non-Gmo: Comparing The Addictiveness Of Corn In Rats, Christian A. Carroll, Sara L. Hill, Kelly A. Huston, Tyler Michael, Courtney Noll, Melissa J. Beck, Ginger Cameron

The Research and Scholarship Symposium

Genetically modified organisms (GMOs) refer to organisms whose DNA has been altered to produce a certain characteristic. GMOs account for a significant proportion of the crops produced in the United States. Specifically, GMO corn accounted for approximately 88% of all corn grown for human and animal consumption in the year 2012. Previously conducted studies have not uniformly demonstrated the safe use of GMO corn, and no studies have been conducted to analyze the addictiveness of GMO corn.

The idea of addiction refers to more than just a physical dependence, but to a psychological dependence on something as well. Addiction is ...


Community Education On Mtm Services, Jacob M. Davis, Kristin Lessig, Lindsay M. Mailloux, Samantha A. Smolinski, Stephen K. Yeboah, Aleda M.H. Chen, Ginger Cameron, Thaddeus T. Franz, Jenna G. Lawhead 2015 Cedarville University

Community Education On Mtm Services, Jacob M. Davis, Kristin Lessig, Lindsay M. Mailloux, Samantha A. Smolinski, Stephen K. Yeboah, Aleda M.H. Chen, Ginger Cameron, Thaddeus T. Franz, Jenna G. Lawhead

The Research and Scholarship Symposium

Background: Medication nonadherence, defined as “the number of doses not taken or taken incorrectly that jeopardizes the patient’s therapeutic outcome,” is a major health problem with about 43% of the general population nonadherent to their medications. Medication nonadherence accounts for an estimated 125,000 deaths per year in the US, 33-69% of medication-related hospital readmissions, and an estimated $100 to $300 billion in direct and indirect medical costs. Medication therapy management (MTM), defined as “a distinct service or group of services that optimize therapeutic outcomes for individual patients,” has been found to reduce medication nonadherence. However, many individuals eligible ...


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