Using A Tailored Health Information Technology Driven Intervention To Improve Health Literacy And Medication Adherence (Talkingrx), Brenda Fay
Characterization Of Physicochemical And Thermal Properties Of Biofield Treated Ethyl Cellulose And Methyl Cellulose, Mahendra Trivedi
Mahendra Kumar Trivedi
Biosimilars In Rheumatology: What The Clinician Should Know, 2016 National Polytechnic Institute
Biosimilars In Rheumatology: What The Clinician Should Know, Gilberto Castaneda-Hernandez, Rodrigo Gonzalez-Ramirez, Jonathan Kay, Morton A. Scheinberg
Biosimilars are now a reality in rheumatology. Although analytical and non-clinical procedures to establish similarity have evolved significantly, clinical trials demonstrating equivalent efficacy and safety are absolutely required for all biosimilars. The design of such trials, including equivalence and non-inferiority statistical approaches, are discussed. Clinical evidence on biosimilars that have been approved recently or are presently being developed for use in rheumatology is also reviewed and contrasted with that available for biomimics (or intended copies), which are non-innovator biologics that are marketed in several countries but have not undergone review according to a regulatory pathway for biosimilars.
Improving Collaboration Between Pharmacists And Physicians, 2016 Butler University
Improving Collaboration Between Pharmacists And Physicians, Paras Patel
Physicians and pharmacists have differing but complementary roles that can optimize patient care when structured effectively. Unfortunately, these two professionals are not collaborating well enough, as patient outcomes, especially in relation to medication adherence, continue to decline. Coordinated care of patients can improve by expanding bidirectional communication and sharing additional patient information with each other. It will be necessary to continue to promote collaborative care in the educational and training stages of these professionals’ careers to build trust and understanding of professional scope. Ultimately, the healthcare infrastructure will have to continue to progress to make collaboration more available and valuable ...
An N Of One: My Review Of Management Of Type 1 Diabetes, Myself As Patient, 2016 Butler University
An N Of One: My Review Of Management Of Type 1 Diabetes, Myself As Patient, Jarred Daugherty
As technology has advanced, so has the management of diabetes. Insulin, the essential medication for type 1 diabetes, is marketed in an array of formulations and devices. Continuous glucose monitors (CGM) can be inserted to measure blood glucose every 5 minutes. The rise of social media has given diabetics online support groups, where they can share their story and learn from others overcoming similar challenges. So, how well do the current diabetes management strategies work? My name Is Jarred and I’m a type 1 diabetic. I have tried many of these products and this article is a review of ...
Pharmaceutical And Industrial Traits In Genetically Modified Crops: Co-Existence With Conventional Agriculture, 2016 Iowa State University
Pharmaceutical And Industrial Traits In Genetically Modified Crops: Co-Existence With Conventional Agriculture, Giancarlo Moschini
This paper discusses the implications of using genetically modified crops to biomanufacture pharmaceuticals and industrial compounds from the perspective of their co-existence with conventional agriculture. Such plant-made pharmaceuticals and plant-made industrial products rely on exciting scientific and technological breakthroughs and promise new opportunities for the agricultural sector, but they also entail novel risks. The management of the externalities and of the possible unintended economic effects that arise in this context is critical and poses difficult questions for regulators.
School Of Pharmacy Inaugural Hooding Ceremony, 2016 Cedarville University
School Of Pharmacy Inaugural Hooding Ceremony, Cedarville University
Doctor of Pharmacy Hooding Ceremony
May 6, 2016
Pharmacologic And Clinical Evaluation Of Posaconazole., 2016 Thomas Jefferson University
Pharmacologic And Clinical Evaluation Of Posaconazole., Jason N. Moore, Jason R. Healy, Walter K. Kraft
Department of Pharmacology and Experimental Therapeutics Faculty Papers
Posaconazole, a broad-spectrum triazole antifungal agent, is approved for the prevention of invasive aspergillosis and candidiasis in addition to the treatment of oropharyngeal candidiasis. There is evidence of efficacy in the treatment and prevention of rarer, more difficult-to-treat fungal infections. Posaconazole oral suspension solution has shown limitations with respect to fasting state absorption, elevated gastrointestinal pH and increased motility. The newly approved delayed-release oral tablet and intravenous solution formulations provide an attractive treatment option by reducing interpatient variability and providing flexibility in critically ill patients. On the basis of clinical experience and further clinical studies, posaconazole was found to be ...
Engineering A Mutation In The Heparin Binding Pocket Of The Human Fibroblast Growth Factor, 2016 University of Arkansas, Fayetteville
Engineering A Mutation In The Heparin Binding Pocket Of The Human Fibroblast Growth Factor, Roshni Patel
Chemistry & Biochemistry Undergraduate Honors Theses
Fibroblast growth factors (FGFs) are family of proteins that belong to a group of growth factors that are found in mammals and play an important role in angiogenesis, differentiation, organogenesis, and tissue repair. In summary, their main functionality is involved in cell division and proliferation. Because FGFs plays such a vital role in cell proliferation, they are mainly involved in the process of wound healing and injuries. FGF binds to its ligand, heparin—a heavily sulfated glycosaminoglycan. The binding of heparin to FGF occurs through electrostatic interactions, specifically between the negatively charged sulfate groups on heparin and positively charged residues ...
An Investigation Into Formulation And Therapeutic Effectiveness Of Nanoparticle Drug Delivery For Select Pharmaceutical Agents, 2016 East Tennessee State Universtiy
An Investigation Into Formulation And Therapeutic Effectiveness Of Nanoparticle Drug Delivery For Select Pharmaceutical Agents, Dustin Cooper
Electronic Theses and Dissertations
Drug based nanoparticle (NP) formulations have gained considerable attention over the past decade for their use in various drug delivery systems. NPs have been shown to increase bioavailability, decrease side effects of highly toxic drugs, and prolong drug release. Furthermore, polymer based, biodegradable nanodelivery has become increasing popular in the field of NP formulation because of their high degree of compatibility and low rate of toxicity. Due to their popularity, commercially available polymers such as poly lactic acid (PLA), poly glycolic acid (PGA) and polylactic-co-glycolic acid (PLGA) are commonly used in the development and design of new nano based delivery ...
Ssri Use In Pregnancy And Congenital Heart Defects: A Meta-Analysis Of Population Based Cohort Studies, 2016 University of Rhode Island
Ssri Use In Pregnancy And Congenital Heart Defects: A Meta-Analysis Of Population Based Cohort Studies, Elizabeth A. Kowalik
Senior Honors Projects
The American College of Obstetricians and Gynecologists estimate that 10-23% of pregnant women in the US face depression at some point during their pregnancy. However, no clear recommendations regarding the treatment of depression in pregnancy are available. Antidepressants are commonly used during pregnancy without clear evidence of their safety. A study of 1,106,757 women in 47 states found that 89,980 (8.1%) had taken an antidepressant at some point during their pregnancy. The Centers for Disease Control and Prevention (CDC) found that 298 (4.5%) of 6582 women in 10 states between the years of 1998 and ...
Medication Use While Breastfeeding With Multiple Sclerosis: A Systematic Literature Review, 2016 University of Tennessee, Knoxville
Medication Use While Breastfeeding With Multiple Sclerosis: A Systematic Literature Review, Brittany Edralin
University of Tennessee Honors Thesis Projects
No abstract provided.
Using Poincaré And Coefficient Analyses To Assess Changes In Variability In Respiration As A Function Of Leptin Status, Sex, And Buprenorphine In Mice, 2016 University of Tennessee, Knoxville
Using Poincaré And Coefficient Analyses To Assess Changes In Variability In Respiration As A Function Of Leptin Status, Sex, And Buprenorphine In Mice, Wateen Hussein Alami
University of Tennessee Honors Thesis Projects
No abstract provided.
A Model For The Voltammetric Behaviour Of Tio2 Memristors, 2016 Dublin Institute of Technology
A Model For The Voltammetric Behaviour Of Tio2 Memristors, John Cassidy, Daryl Fox, Tony Betts
Abstract A model is solved based on the Nernst Planck equation to calculate the diffusion and migration currents for a species in a thin layer (about 200 nm) confined between two electrodes. This is proposed to account for the current voltage behaviour of a memristor constructed in a similar fashion. At the working electrode, an electroactive species is oxidised and at the counter electrode, the same species is reduced. Upon application of a simple voltammetric waveform, the migration current exhibits a resistance profile at slow scan rates and hysteresis at faster scan rates, indicative of memristor behavior.
Urinary Alkalisation For Symptomatic Uncomplicated Urinary Tract Infection In Women (Review), Dermot B. O'Kane, Sameer Dave, Neel Gore, Farhaan Patel, Tammy Hoffmann, Jeanne L. Trill, Chris Del Mar
Christopher Del Mar
Uncomplicated urinary tract infection (UTI) is the most common bacterial infection in women, characterised by dysuria and urinary frequency. Urinary alkalisers are widely used in some countries for the symptomatic treatment of uncomplicated UTI, and they are recommended in some national formularies. However, there is a lack of empirical evidence to support their use for UTI and some healthcare guidelines advise against their use.
We aimed to look at the benefits and harms of the use of urinary alkalisers for the treatment of uncomplicated UTIs in adult women.
We searched the Cochrane Kidney and Transplant Specialised ...
Which Drugs Cause Cancer?, 2016 Animal Consultants International
Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, Jonathan Balcombe
Andrew Knight, BSc (Vet Biol), BVMS, MANZCVS, DipECAWBM (AWSEL), DACAW, PhD, MRCVS, SFHEA
Animal tests yield misleading results.
Rapid Effects Of Aldosterone And Spironolactone In The Isolated Working Rat Heart, 2016 Marshall University
Rapid Effects Of Aldosterone And Spironolactone In The Isolated Working Rat Heart, John C. Barbato, Patrick J. Mulrow, Joseph I. Shapiro Md, Roberto Franco-Saenz
Joseph I Shapiro MD
Chronic administration of aldosterone promotes myocardial fibrosis in rats. The Randomized Aldactone Evaluation Study reported that the aldosterone antagonist spironolactone improved outcome in patients with congestive heart failure, suggesting a deleterious effect of aldosterone in the heart. Aldosterone has been shown to have rapid nongenomic effects in different tissues including the heart. However, the hemodynamic actions of aldosterone and spironolactone are not well characterized. In this study, we examined the hemodynamic effects of aldosterone and its receptor antagonist, spironolactone, in the isolated rat heart by use of the Langendorff-Neely technique. Perfusion with 10 nmol/L aldosterone increased contractility by 45 ...
Reduction Of Na/K-Atpase Affects Cardiac Remodeling And Increases C-Kit Cell Abundance In Partial Nephrectomized Mice, Christopher A. Drummond, Moustafa Sayed, Kaleigh L. Evans, Huilin Shi, Xiaoliang Wang, Steven T. Haller, Jiang Liu, Christopher J. Cooper, Zijian Xie, Joseph I. Shapiro Md, Jiang Tian
Joseph I Shapiro MD
The current study examined the role of Na/K-ATPase α1-subunit in animals subjected to 5/6th partial nephrectomy (PNx) using Na/K-ATPase α1-heterozygous (α1(+/-)) mice and their wild-type (WT) littermates. After PNx, both WT and α1(+/-) animals displayed diastolic dimension increases, increased blood pressure, and increased cardiac hypertrophy. However, in the α1(+/-) animals we detected significant increases in cardiac cell death in PNx animals. Given that reduction of α1 elicited increased cardiac cell death with PNx, while at the same time these animals developed cardiac hypertrophy, an examination of cardiac cell number, and proliferative capabilities of those cells was carried ...
Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, 2016 Dublin Institute of Technology
Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, Emer H. Shannon, Nissreen Abu-Ghannam
The marine environment is home to a taxonomically diverse ecosystem. Organisms such as algae, molluscs, sponges, corals, and tunicates have evolved to survive the high concentrations of infectious and surface-fouling bacteria that are indigenous to ocean waters. Both macroalgae (seaweeds) and microalgae (diatoms) contain pharmacologically active compounds such as phlorotannins, fatty acids, polysaccharides, peptides, and terpenes which combat bacterial invasion. The resistance of pathogenic bacteria to existing antibiotics has become a global epidemic. Marine algae derivatives have shown promise as candidates in novel, antibacterial drug discovery. The efficacy of these compounds, their mechanism of action, applications as antibiotics, disinfectants, and ...
The Effect Of Luteolin On Human Glioblastoma, 2016 Cedarville University
The Effect Of Luteolin On Human Glioblastoma, David M. Anson, Samson Amos, Robert L. Paris, Denise S. Simpson
The Research and Scholarship Symposium
Glioblastoma multiforme (GBM) is widely recognized as the most common and lethal of the malignant gliomas. Few effective therapeutic treatments are available as five-year survival rates of diagnosed individuals are less than five percent. Luteolin, a common flavonoid found in a variety of fruits and vegetables, has demonstrated significant promise in combating cancers of the breast, colon, liver, lung, and bone. In this study, we investigated the effects of luteolin on glioblastoma multiforme cell lines U-251, U-87, and U-1242. Cell viability was assessed using cell count with trypan blue exclusion and MTT assays. Results revealed that luteolin reduces GBM cell ...