Pharmacy and Pharmaceutical Sciences Commons^™

Stability Of An Alternative Extemporaneous Captopril Fast-Dispersing Tablet Formulation Versus An Extemporaneous Oral Liquid Formulation., Ritesh M. Pabari, Claire Mcdermott, James Barlow, Zebunnissa Ramtoola

School of Pharmacy Articles

BACKGROUND: Administration of medications to pediatric patients is challenging because many drugs are not commercially available in appropriate dosage formulations and/or strengths. Consequently, these drugs are prepared extemporaneously as oral liquid (OL) formulations using marketed tablets or capsules. In many cases, the stability of these extemporaneous preparations, which may affect their tolerability, has not been documented. An alternative extemporaneous solid formulation, such as a fast-dispersing tablet (FDT), may offer enhanced stability as well as dosing flexibility because it may be administered as an orodispersible tablet or as a reconstituted suspension/solution. Although FDTs are available increasingly as patient-friendly oral ...

Application Of Face Centred Central Composite Design To Optimise Compression Force And Tablet Diameter For The Formulation Of Mechanically Strong And Fast Disintegrating Orodispersible Tablets., Ritesh M. Pabari, Zebunnissa Ramtoola

School of Pharmacy Articles

A two factor, three level (3(2)) face centred, central composite design (CCD) was applied to investigate the main and interaction effects of tablet diameter and compression force (CF) on hardness, disintegration time (DT) and porosity of mannitol based orodispersible tablets (ODTs). Tablet diameters of 10, 13 and 15 mm, and CF of 10, 15 and 20 kN were studied. Results of multiple linear regression analysis show that both the tablet diameter and CF influence tablet characteristics. A negative value of regression coefficient for tablet diameter showed an inverse relationship with hardness and DT. A positive value of regression coefficient ...

Investigation Of A Novel 3-Fluid Nozzle Spray Drying Technology For The Engineering Of Multifunctional Layered Microparticles., Ritesh M. Pabari, Tara Sunderland, Zebunnissa Ramtoola

School of Pharmacy Articles

OBJECTIVE: To examine the potential of a novel 3-fluid nozzle spray drying technology to formulate differentiated layered microparticles (MPs) of diclofenac sodium (DFS)/ethyl cellulose (EC).

METHODS: DFS/EC MPs were formulated using the inner and/or outer nozzles of a novel 3-fluid nozzle and compared with MPs formed using conventional (2-fluid) spray drying. MPs were characterised for particle size and for morphology by TEM and SEM. Distribution of DFS and EC of MPs was analysed by FT-IR and DSC. A two-factor, three-level (3(2)) factorial design was applied to investigate the effect and interaction of total feed solid content ...

The Impact Of Community Use Of Novel Oral Anticoagulants On An Academic Medical Center, Luis Eraso, Md, Taki Galanis, Md, Kristina Kipp, Pharm.D., Walter K. Kraft, Md, Michael Palladino, Pharm.D., Cacp, Alejandro Perez, Md, Kimberle Ferebee-Spruill, Crnp, Geno Merli, Md, Brian G. Swift, Pharm.D., Mba, Lynda Thomson, Brittany Vining

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Warfarin has been a mainstay of therapy for treatment and prevention of venous thromboembolic disease (VTED) and prevention of stroke and systemic embolism for over 50 years. Recent FDA approval of several novel oral anticoagulants has offered more extensive treatment options for management of these disease states.

The availability of the novel anticoagulants offers an attractive alternative to warfarin therapy for patients due to their convenience of use. In comparison to warfarin, dabigatran, rivaroxaban and apixaban offer: - a fixed dosage regimen

- a relatively small potential drug interaction profile

- minimal laboratory monitoring

- little to no dietary restrictions.

Although these agents offer ...

The Effect Of Any Willing Provider And Freedom Of Choice Laws On Health Care Expenditures, Jonathan Klick, Joshua D. Wright

Faculty Scholarship

Any Willing Provider and Freedom of Choice laws restrict the ability of managed care entities, including pharmacy benefit managers, to selectively contract with providers. The managed care entities argue this limits their ability to generate cost savings, while proponents of the laws suggest that such selective contracts limit competition, leading to an increase in aggregate costs. We examine the effect of state adoption of such laws on total state healthcare spending, finding that any willing provider/freedom of choice laws are associated with cost increases of at least 3 percent. These results suggest that these laws are harmful from a ...

Preclinical And Clinical Development Of The Lipophilic Camptothecin Analogue Ar-67, Eleftheria Tsakalozou

Theses and Dissertations--Pharmacy

AR-67 is a lipophilic third generation camptothecin analogue, currently under early stage clinical trials. It acts by targeting Topoisomerase 1 (Top1), a nuclear enzyme essential for DNA replication and transcription and is present in two forms, the pharmacologically active lipophilic lactone and the charged carboxylate. In oncology patients participating in a phase I clinical trial, AR-67 lactone was the predominant species in plasma. Similarly to other camptothecins, the identified dose-limiting toxicities for AR-67 were neutropenia, thrombocytopenia and fatigue. In addition, in vitro metabolism studies indicated AR-67 lactone as a substrate for CYP3A4/5 as well as the UGT1A7 and UGT1A8 ...

Isolation And Partial Characterization Of Bioactive Fucoxanthin From Himanthalia Elongata Brown Seaweed: A Tlc-Based Approach, Gaurav Rajauria, Nissreen Abu-Ghannam

Articles

Seaweeds are important sources of carotenoids, and numerous studies have shown the beneficial effects of these pigments on human health. In the present study, Himanthalia elongata brown seaweed was extracted with a mixture of low polarity solvents, and the crude extract was separated using analytical thin-layer chromatography (TLC).The separated compounds were tested for their potential antioxidant capacity and antimicrobial activity against Listeria monocytogenes bacteria using TLC bioautography approach. For bio-autography, the coloured band on TLC chromatogram was visualized after spraying with DPPH and triphenyltetrazolium chloride reagents which screen antioxidant and antimicrobial compounds, respectively, and only one active compound was ...

In-House Mentorship, Reza Karimi

Faculty Scholarship (PHRM)

No abstract provided.

Perception, Expression And Management Of The Pain Of Childbirth, Mary H. Christenson

Senior Honors Papers

In order to be a competent nurse on an American labor and delivery unit it is important to have an understanding of the pain of childbirth. This includes a thorough understanding of pain as a sensation and its manifestation during the birthing experience. An understanding of pain is useless, however, unless standardized pain assessment practices are used. The most accurate pain assessment is associated with a general understanding of cultural trends in pain perception and expression. Along with culture, other factors also influence how a woman senses and copes with the pain of labor. Anxiety is one of these influential ...

Oral Contraceptives, Stephenie G. Fortier

Senior Honors Papers

Cyclic oral contraceptive and continuous oral contraceptives have many similarities yet a few distinct differences. One of the major differences between cyclic and continuous oral contraceptives is that cyclic oral contraceptive pills have twenty one active pills and seven inactive pills versus the new continuous oral contraceptive pills which have 28 active pills and no inactive pills. However, though cyclic and continuous oral contraceptives do have a few differences, both types of oral contraceptives affect a woman’s body in similar ways. When choosing between cyclic and continuous oral contraceptives, it is important for women to be informed about the ...

Towards Elucidation Of A Viral Dna Packaging Motor, Chad T. Schwartz

Theses and Dissertations--Pharmacy

Previously, gp16, the ATPase protein of phi29 DNA packaging motor, was an enigma due to its tendency to form multiple oligomeric states. Recently we employed new methodologies to decipher both its stoichiometry and also the mechanism in which the protein functions to hydrolyze ATP and provide the driving force for DNA packaging. The oligomeric states were determined by biochemical and biophysical approaches. Contrary to many reported intriguing models of viral DNA packaging, it was found that phi29 DNA packaging motor permits the translocation of DNA unidirectionally and driven cooperatively by three rings of defined shape. The mechanism for the generation ...

Acute Vibration Induces Transient Expression Of Anabolic Genes In The Murine Intervertebral Disc, Matthew R. Mccann, Priya Patel, Kim L. Beaucage, Yizhi Xiao, Corey Bacher, Walter L. Siqueira, David W. Holdsworth, S. Jeffrey Dixon, Cheryle A. Séguin

Physiology and Pharmacology Publications

No abstract provided.

Patients' Perceptions Of Community Pharmacists Giving Vaccinations, Darlinghton O. Njoku, Vineeta Rao, Morgan R. Bailey, Matt Madden, Joshua A. Sitler, Tracy R. Frame

The Research and Scholarship Symposium

No abstract provided.

Stemming The Global Trade In Falsified And Substandard Medicines, Lawrence O. Gostin, Gillian J. Buckley, Patrick W. Kelley

Georgetown Law Faculty Publications and Other Works

Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and the problem is far more common and serious in low- and middle-income countries with weak drug regulatory systems. An Institute of Medicine consensus committee report identified the causes and possible solutions to the problem of falsified and substandard drugs around the world.

The vocabulary people use to discuss the problem is itself a concern. The word counterfeit is often used innocuously to ...

Emergency Contraceptive (Ec) Use In Indigent Populations, Ashley Benjamin, Kasandra Chambers, Melissa Mcnicol, Amy Roy, Kurtis Schultz, April Yoakam, Miriam A. Ansong, Pharm.D., Tracy R. Frame, Ph.D.

The Research and Scholarship Symposium

No abstract provided.

A Case Study On Pharmacy To Explore The Perceptions Of Pharmacy Leaders And Policy Makers On The Benefits, Risks, And Alternatives Of The Doctorate As The Entry Level Degree In Health Professions, Heidi Marie Crocker

Dissertations

The clinical doctorate is an emergent trend in many health profession disciplines. Collier (2008) projects continued momentum toward higher degrees for entry into practice and advancing the field in health professions. There has been minimal research on how the trend of doctoral education in health professions will affect health professions education, delivery of services, and interdisciplinary relationship among health care providers, or the wider society (Freburger, King, & Slifkin, 2008). This research focused on the transition to the clinical doctorate in one profession, Pharmacy, retrospectively examining the inception and enactment phase of the Pharm.D. The study provides important insight into ...

Impact Of A Pharmacist-Managed Smoking Cessation Program, Alexandra Archambault, Belinda Darkwah, Kale Hanavan, Ellery Kent, Myriam Shaw Ojeda, Larisa Yuchimiuk, Kelly J. Hiteshew, Pharm.D.

The Research and Scholarship Symposium

No abstract provided.

Patient Satisfaction With Pharmacist Counseling, Kristina Burban, Samuel Franklin, Sarah Marks, Trevor Reed, Brandon Spears, Aleda M. H. Chen, Ph.D.

The Research and Scholarship Symposium

No abstract provided.

Genetic Manipulation Of Leishmania Parasites Facilitates The Exploration Of The Polyamine Biosynthetic Pathway As A Potential Therapeutic Target, Sigrid C. Roberts

Faculty Scholarship (PHRM)

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases, ranging from cutaneous ulcerative lesions to fatal visceralizing infections that affect an estimated 12 million people worldwide. Unfortunately, vaccines are not available and the cturent arsenal of drugs used to treat leishmaniasis is far from ideal. Thus the need for new therapeutic targets and a better understanding of host-parasite interactions is urgent. One biochemical pathway that has been successfully exploited for the treatment of a related parasitic disease, African trypanosomiasis, is the polyamine biosynthetic pathway. In order to elucidate the polyamine biosynthetic pathway and to explore ...

Embedded Assessment And Evidence-Based Curriculum Mapping: The Promise Of Learning Analytics, Jane M. Souza

Pharmacy Faculty Publications

At Wegmans School of Pharmacy, we have adopted an embedded assessment approach to curriculum mapping and data collection on student learning outcomes achievement. In essence, we capture the data from the course level exams that our faculty members craft to measure student learning.