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Synthesis Of Novel Library Of Cyanopyrrolidinyl Beta-Amino Alcohols And Matrine Alkaloids, Xiaotian Chen 2019 Rowan University

Synthesis Of Novel Library Of Cyanopyrrolidinyl Beta-Amino Alcohols And Matrine Alkaloids, Xiaotian Chen

Theses and Dissertations

Cyanopyrrolidines and beta-Amino alcohols are molecular scaffolds that are highly found in commercially available drugs. We developed a multi-step synthetic method to form a novel library of compounds as inhibitors that share both scaffolds toward potent and selective diabetes therapeutics. Despite the ease for the synthesis of Cyanopyrrolidines, the difficulty of forming high selective beta-Amino alcohols is challenging. We successfully find the best condition for the preference of highly selective mono-alkylation and double-alkylation products and produce them with high yield.

Matrine is an alkaloid found in plants from the genus Sophora and can produce some pharmacological effects such as anti-cancer ...


The Opioid Crisis In America As It Effects Health Care Professionals, Patients, And The Economy, dale russell 2019 University of Lynchburg

The Opioid Crisis In America As It Effects Health Care Professionals, Patients, And The Economy, Dale Russell

Lynchburg Journal of Medical Science

Abstract

There is a growing concern in America over the increasing morbidity and mortality associated

with the use and abuse of opioid pain relievers. This alarming increase has led to the term

“crisis” when referring to these facts. Addressing this crisis is multi-focused. The need to prevent

and treat opioid addiction is on the forefront. These needs are seen in both the prescription of

opioids as well as the illicit use of non-prescription opioids. Overprescribing opioids has led to

an increase of abuse and addiction to these substances. This in turn has led to a rise in street use

of ...


Icatibant Is Not Helpful For The Treatment Of Ace Inhibitor-Induced Angioedema, Samantha R. Schwartz 2019 Wayne State University School of Medicine

Icatibant Is Not Helpful For The Treatment Of Ace Inhibitor-Induced Angioedema, Samantha R. Schwartz

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Sinert R, Levy P, Bernstein JA, et al. Randomized trial of icatibant for angiotensin-converting enzyme inhibitor-induced upper airway angioedema. J Allergy Clin Immunol Pract. 2017; 5(5): 1402-1409. doi: 10.1016/j.jaip.2017.03.003.


Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston 2019 University of Kentucky

Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston

Pharmaceutical Sciences Faculty Patents

The invention relates to isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention relates to uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.


Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston 2019 University of Kentucky

Cytochrome P450s And Uses Thereof, Joseph Chappell, Lyle F. Ralston

Pharmaceutical Sciences Faculty Patents

The invention relates to isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention relates to uses of such molecules in methods of increasing the level of resistance against a disease caused by a plant pathogen in a transgenic plant, in methods for producing altered compounds, for example, hydroxylated compounds, and in methods of producing isoprenoid compounds.


Choline Is An Intracellular Messenger Linking Extracellular Stimuli To Ip3-Evoked Ca2+ Signals Through Sigma-1 Receptors, Eugen Brailoiu, Sumita Chakraborty, G. Cristina Brailoiu, Pingwei Zhao, Jeffrey L. Barr, Marc A. Ilies, Ellen M. Unterwald, Mary E. Abood, Colin W. Taylor 2019 Temple University

Choline Is An Intracellular Messenger Linking Extracellular Stimuli To Ip3-Evoked Ca2+ Signals Through Sigma-1 Receptors, Eugen Brailoiu, Sumita Chakraborty, G. Cristina Brailoiu, Pingwei Zhao, Jeffrey L. Barr, Marc A. Ilies, Ellen M. Unterwald, Mary E. Abood, Colin W. Taylor

College of Pharmacy Faculty Papers

Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the ER. The endogenous ligands of Sig-1Rs are unknown. Phospholipase D (PLD) cleaves phosphatidylcholine to choline and phosphatidic acid (PA), with PA assumed to mediate all downstream signaling. We show that choline is also an intracellular messenger. Choline binds to Sig-1Rs, it mimics other Sig-1R agonists by potentiating Ca2+ signals evoked by IP3Rs, and it is deactivated by metabolism. Receptors, by stimulating ...


Bishydrazone-Based Antifungal Agents, Sylvie Garneau-Tsodikova, David S. Watt 2019 University of Kentucky

Bishydrazone-Based Antifungal Agents, Sylvie Garneau-Tsodikova, David S. Watt

Pharmaceutical Sciences Faculty Patents

Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.


College Of Pharmacy 2019, Nova Southeastern University 2019 Nova Southeastern University

College Of Pharmacy 2019, Nova Southeastern University

Health Professions Divisions Course Catalogs

No abstract provided.


Providers’ Perception Of Alert Fatigue After Implementation Of User-Filtered Warnings, Hina Afaq, Sahaana Mukundan, Sadaf Zia, Alisa K. Escano Dr., Rebecca Lear Dr., Casey Washington Dr. 2019 VCU School of Pharmacy

Providers’ Perception Of Alert Fatigue After Implementation Of User-Filtered Warnings, Hina Afaq, Sahaana Mukundan, Sadaf Zia, Alisa K. Escano Dr., Rebecca Lear Dr., Casey Washington Dr.

Pharmacotherapy and Outcomes Science Publications

Alert fatigue is a complex problem that many health institutions face when using an electronic health record (EHR). The addition of user-filtered warnings (UFW) is a physicians’ proposed intervention at Inova Health System (IHS), a large 5-hospital health system in Northern Virginia, that allows prescribers to filter out specific drug-drug interactions and pregnancy and lactation medication alerts for a 30-day period. This study aims to determine the impact of UFW on physicians’ perception of alert fatigue and to calculate the reduction of medication alerts. It was hypothesized that the reduction in alerts will significantly impact physicians’ perception of alert fatigue ...


Carbapenem-Resistant Enterobacteriaceae: Epidemiology, Genetics, In Vitro Activity, And Pharmacodynamic Modeling, Brandon Kulengowski 2019 University of Kentucky

Carbapenem-Resistant Enterobacteriaceae: Epidemiology, Genetics, In Vitro Activity, And Pharmacodynamic Modeling, Brandon Kulengowski

Theses and Dissertations--Pharmacy

Background: Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) such as Escherichia coli and Klebsiella pneumoniae are among the most urgent threats of the infectious disease realm. The incidence of these infections has been increasing over the years and due to very limited treatment options, mortality is estimated at about 50%. By 2050, mortality from antimicrobial resistant infections is expected to surpass cancer at 10 million deaths annually.

Methods: We evaluated 18 contemporary antimicrobials against 122 carbapenem-resistant Enterobacteriaceae using a variety of antimicrobial susceptibility testing methods according to Clinical Laboratory Standards Institute guidelines. Time-kill studies were performed on clinical isolates with variable ...


Anti-Inflammatory, Anti-Nociceptive And Antipyretic Activity Of Young And Old Leaves Of Vernonia Amygdalina, Du-Bois Asante, Isaac Tabiri Henneh, Desmond Omane Acheampong, Foster Kyei, Christian Kweku Adokoh, Eric Gyamerah Ofori, Nelson Kwabla Domey, Emmanuel Adakudugu, Lokeswari Prathyusha Tangella, Elvis Ofori Ameyaw 2019 Edith Cowan University

Anti-Inflammatory, Anti-Nociceptive And Antipyretic Activity Of Young And Old Leaves Of Vernonia Amygdalina, Du-Bois Asante, Isaac Tabiri Henneh, Desmond Omane Acheampong, Foster Kyei, Christian Kweku Adokoh, Eric Gyamerah Ofori, Nelson Kwabla Domey, Emmanuel Adakudugu, Lokeswari Prathyusha Tangella, Elvis Ofori Ameyaw

ECU Publications Post 2013

Background

Both young and old leaves of Vernonia amygdalina (VA) are traditionally used to treat inflammation, pain and fever. However, the efficacy of young and old leaves for treating these ailments have not been compared till date.

Aim

To ascertain the effect of young and old leaves of VA in managing inflammation, pain and fever.

Methods

Both quantitative and qualitative phytochemical screening of ethanol extracts of young (EthYL) and old (EthOL) leaves of VA were performed. The anti-inflammatory activity of orally administered EthYL and EthOL (50–200 mg/kg) and Diclofenac (10 mg/kg) were evaluated in carrageenan-induced inflammation model ...


Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan 2018 University of Kentucky

Mutants Of Cocaine Esterase, Donald Landry, Chang-Guo Zhan

Pharmaceutical Sciences Faculty Patents

Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.


Community Pharmacists And Substance Use Disorders: Attitudes, Knowledge And Practices, Deepika Rao 2018 Duquesne University

Community Pharmacists And Substance Use Disorders: Attitudes, Knowledge And Practices, Deepika Rao

Electronic Theses and Dissertations

Background: Substance use disorder (SUD) is a serious health concern affecting a large proportion of the US population. Community pharmacists are well-positioned to prevent, screen, and provide appropriate treatment for SUD. Stigma towards these patients and SUD results in reduced quality of care as well as poor treatment outcomes. It is imperative that pharmacists have the appropriate knowledge of and attitude towards prevention, harm reduction and treatment to develop therapeutic relationships and improve their delivery of pharmacy services

Objective: To assess knowledge, practices (with an emphasis upon screening), stigma and general attitudes of community pharmacists towards SUD and evaluate the ...


Characterization Of G-Protein Coupled Receptors In Pain, Depression And Anxiety, Neil Lax 2018 Duquesne University

Characterization Of G-Protein Coupled Receptors In Pain, Depression And Anxiety, Neil Lax

Electronic Theses and Dissertations

Chronic pain and major depressive disorder are widespread conditions in the world. Interestingly, these conditions often occur comorbidly, with each individual disease amplifying the symptoms of the other. A significant amount of preclinical research in pain and depression focuses on G-protein coupled receptors (GPCRs), implying that GPCRs may be useful in treating this comorbidity. Our efforts have sought to characterize several poorly understood GPCRs, including the serotonin receptor subtypes 2C and 7 (5-HT2CR and 5-HT7R) and metabotropic glutamate receptor 5 (mGluR5), along with more well-known GPCRs such as the mu opioid receptor (MOR), and the role that they play in ...


Actinomycin Heterocyle Thesis 122018 For Submission.Pdf, Matt McErlean 2018 University of Kentucky

Actinomycin Heterocyle Thesis 122018 For Submission.Pdf, Matt Mcerlean

Matt McErlean

Actinomycins are a class of compounds consisting of phenoxazinone-like core attached to two peptidolactone rings, denoted as α and β. A unique component of a few families—actinomycins G, Y, and Z—is a chlorinated β-ring threonine residue. Families G and Y also contained an actinomycin that possess a β-ring heterocycle (actinomycins G5 and Y5, respectively); prior to this work, no β-ring heterocycle-containing actinomycins were reported for the Z family. Unlike other actinomycin derivatives, Y5’s cytotoxicity was abolished while still maintaining some antibacterial potency.
We constructed a model compound to probe the physical properties of the actinomycin core to ...


A Comparison Of Student Pharmacist Clinical Interventions During An Internal Medicine Advanced Pharmacy Practice Experience (Appe) In A High-Income Versus Low-Income Setting, Ellen Schellhase, Monica Miller, Shelby Wilkinson, Rakhi Karwa 2018 Purdue University

A Comparison Of Student Pharmacist Clinical Interventions During An Internal Medicine Advanced Pharmacy Practice Experience (Appe) In A High-Income Versus Low-Income Setting, Ellen Schellhase, Monica Miller, Shelby Wilkinson, Rakhi Karwa

Engagement & Service-Learning Summit: Connecting Through Listening & Scholarship

Objectives: Compare and contrast the number and type of interventions made by student pharmacists who participated in an adult internal medicine APPE in the US to an internal medicine APPE in Kenya.

Methods: A US-based faculty-led, four-week internal medicine APPE with interprofessional team rounding that provides care for underserved patients in an urban setting and hosts 16 students annually was compared to a faculty-led, eight-week internal medicine APPE in Kenya that hosts on average 24 students annually. Starting May 2017 – January 2018 a standard clinical intervention collection form was used by all students on these two APPEs starting the first ...


Save The Pharmacy Piggy Bank: Managing Mega High-Cost Drugs, Richard K. Ogden Jr., Jerame Hill, Sam Abdelghany 2018 Children's Mercy Hospital

Save The Pharmacy Piggy Bank: Managing Mega High-Cost Drugs, Richard K. Ogden Jr., Jerame Hill, Sam Abdelghany

Pharmacy Presentations

No abstract provided.


Executive Summary: A Comprehensive Report On Marijuana: Focus On The Paso Del Norte Region, Gabriel Frietze, Nora Hernandez, José O. Rivera 2018 University of Texas at El Paso

Executive Summary: A Comprehensive Report On Marijuana: Focus On The Paso Del Norte Region, Gabriel Frietze, Nora Hernandez, José O. Rivera

Departmental Papers (Pharmacy)

No abstract provided.


A Comprehensive Report On Marijuana: Focus On The Paso Del Norte Region, Gabriel Frietze, Nora Hernandez, José O. Rivera 2018 University of Texas at El Paso

A Comprehensive Report On Marijuana: Focus On The Paso Del Norte Region, Gabriel Frietze, Nora Hernandez, José O. Rivera

Departmental Papers (Pharmacy)

The present executive summary highlights topics discussed within a comprehensive and extensive report on marijuana. This condensed summary discusses the chemical compounds within marijuana, the various methods of consuming marijuana, the therapeutic effects and health consequences associated with marijuana use, and repercussions that have emerged as a result of the legalization of marijuana in many states within the United States. Additionally, the impact of marijuana in communities within the Paso del Norte Region are discussed.

Read more: Executive Summary


The Incidence And Severity Of Drug Interactions Before And After Antiretroviral Therapy Simplification In Treatment Experienced Patients With Hiv Infection, Aleena Santana, PharmD Candidate, Nick Hastain, PharmD Candidate, Jason J. Schafer, PharmD, MPH, BCPS, AAHIVP 2018 Thomas Jefferson University

The Incidence And Severity Of Drug Interactions Before And After Antiretroviral Therapy Simplification In Treatment Experienced Patients With Hiv Infection, Aleena Santana, Pharmd Candidate, Nick Hastain, Pharmd Candidate, Jason J. Schafer, Pharmd, Mph, Bcps, Aahivp

College of Pharmacy Posters

Purpose

  • The primary objective of this study was to assess changes in the incidence and severity of drug interactions before and after ART simplification in treatment experienced patients.
  • Describe ART medication class changes and analyze predictors for achieving drug interaction score reductions.


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