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Variability In Naltrexone Biotransformation, Stephani L. Stancil 2020 Children's Mercy Kansas City

Variability In Naltrexone Biotransformation, Stephani L. Stancil

Research Days

No abstract provided.


Possible Role Of Tetracyclines On Covid-19: Recycling Well-Known Old Drugs From The Shelf, Martin Gnoni, Raul Vasquez-Gararatti, Angel Mena 2020 University of Louisville; Tri-Health Good Samaritan Hospital; University of Pikeville

Possible Role Of Tetracyclines On Covid-19: Recycling Well-Known Old Drugs From The Shelf, Martin Gnoni, Raul Vasquez-Gararatti, Angel Mena

The University of Louisville Journal of Respiratory Infections

We are in the midst of a pandemic due to the novel coronavirus SARS-CoV-2. Innovative therapies are in the lookup around the world. Recently, chloroquine and hydroxychloroquine in addition to Azithromycin were proposed to be used in patients with severe disease even though strong evidence is lacking. We propose the use of tetracyclines in addition to anti-virals early in the curse of the disease in order to prevent the Cytokine Storm Syndrome associated with COVID-19 and prevent ARDS. The proposed mechanisms of tetracyclines are: 1) anti-apoptotic properties; 2) decrease the Myeloperoxidase and ROS releaser from immune cells; 3) decrease neutrophil ...


Dgat Activity Is Dispensable For Myeloma Cell Proliferation, C S. Murphy, H Campbell, V DeMambro, M Farrell, S Costas, C Vary, M R. Reagan 2020 Maine Medical Center

Dgat Activity Is Dispensable For Myeloma Cell Proliferation, C S. Murphy, H Campbell, V Demambro, M Farrell, S Costas, C Vary, M R. Reagan

Costas T. Lambrew Research Retreat 2020

Multiple myeloma (MM) is the third most common blood cancer and is defined by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains incurable due to the development of resistance to current chemotherapies; therefore, it is paramount to investigate novel treatments and the mechanisms of drug resistance in multiple myeloma cells. Recently, changes in both catabolic and anabolic lipid metabolism have been shown to support the proliferation, migration and the development of drug resistance in breast, prostate, and ovarian cancer. However, the role of lipid metabolism in myeloma cells has been understudied. Given the data ...


Innovations At Mainehealth-Introduction, Susan Ahern 2020 Maine Medical Center

Innovations At Mainehealth-Introduction, Susan Ahern

Costas T. Lambrew Research Retreat 2020

Where every colleague is welcome and we create a culture of innovation together, where we focus on the important unmet needs, and discover low tech, high impact solutions, where collaboration is critical and pivoting is part of the game, where we fail fast but have fun doing it, where we innovate with you...not for you, where we are one and we are better together.


Mainehealth Innovation Covid-19 Successes, Susan Ahern 2020 Maine Medical Center

Mainehealth Innovation Covid-19 Successes, Susan Ahern

Costas T. Lambrew Research Retreat 2020

Hand sanitizer, collapsible aerosol particle enclosures (CAPE), ventilator splitter, N95 UV Mask decontamination, aerosol boxes


Mmc Biobank: A Resource For Translational Research., Anne C. Breggia, Sue LaPierre, Christopher Keister, Hanna Renedo, Dawn Charnetzky, Hannah Brown, Howard Feller, Susan Nester, Robert Christman, Michael Jones, Tony Sellner, Liz Hamir, Lindsay Cote, Heidi Ingersoll 2020 Maine Medical Center

Mmc Biobank: A Resource For Translational Research., Anne C. Breggia, Sue Lapierre, Christopher Keister, Hanna Renedo, Dawn Charnetzky, Hannah Brown, Howard Feller, Susan Nester, Robert Christman, Michael Jones, Tony Sellner, Liz Hamir, Lindsay Cote, Heidi Ingersoll

Costas T. Lambrew Research Retreat 2020

BioBank Director develops an Internal Investigator protocol which outlines collection logistics, sample processing, communications with clinical personnel for executing the study plan and transport of samples to MMCRI.


Microrna199b Regulates Mouse Hematopoietic Stem Cells Maintenance, Aldona A. Karaczyn, Edward Jachimowicz, Jaspreet S. Kohli, Pradeep Sathyanarayana 2020 Maine Medical Center

Microrna199b Regulates Mouse Hematopoietic Stem Cells Maintenance, Aldona A. Karaczyn, Edward Jachimowicz, Jaspreet S. Kohli, Pradeep Sathyanarayana

Costas T. Lambrew Research Retreat 2020

The preservation of hematopoieticstem cell pool in bone marrow (BM) is crucial for sustained hematopoiesisin adults. Studies assessing adult hematopoieticstem cells functionality had been shown that for example loss of quiescence impairs hematopoieticstem cells maintenance. Although, miR‐199b is frequently down‐regulated in acute myeloid leukemia, its role in hematopoieticstem cells quiescence, self‐renewal and differentiation is poorly understood. Our laboratory investigated the role of miR‐199b in hematopoieticstem and progenitor cells (HSPCs) fate using miR‐199b‐5p global deletion mouse model. Characterization of miR‐199b expression pattern among normal HSPC populations revealed that miR‐199b is enriched in LT ...


Loss Of Vitamin A Stores Impairs Cardiac Workload And Function Under Stress Conditions, Amanda J. Favreau‐Lessard, MaryAnn Asson‐Batres, Douglas B. Sawyer, Ilka Pinz 2020 Maine Medical Center

Loss Of Vitamin A Stores Impairs Cardiac Workload And Function Under Stress Conditions, Amanda J. Favreau‐Lessard, Maryann Asson‐Batres, Douglas B. Sawyer, Ilka Pinz

Costas T. Lambrew Research Retreat 2020

Study Objectives: Assess cardiac function under baseline and cardiac stress conditions in mice with and without hepatic vitamin A stores.


Irisin Stimulates Osteoclast Differentiation And Function, Eben Estell, Phuong Le, Yosta Vegting, Hyeonwoo Kim, Roland Baron, Bruce Spiegelman, Clifford Rosen 2020 Maine Medical Center

Irisin Stimulates Osteoclast Differentiation And Function, Eben Estell, Phuong Le, Yosta Vegting, Hyeonwoo Kim, Roland Baron, Bruce Spiegelman, Clifford Rosen

Costas T. Lambrew Research Retreat 2020

Irisin is the cleaved product of the protein FNDC5 expressed in skeletal muscle, and is increased by exercise. Recent work suggests this myokine is a modulator of muscle-bone crosstalk. Irisin has been shown to increase bone formation (Colaiannia, PNAS 2015), prevent disuse-associated bone loss (Colaiannia, Sci Rep 2017), and directly stimulate osteoblasts (Colaiannia, Int J Endo 2014). These results demonstrate an anabolic function, but the full mechanisms of action on each key cell type in bone, and the relative impacts of irisin on bone formation, resorption, and coupled remodeling have yet to be elucidated. Converse to an anabolic role, genetic ...


Simulation – Based Testing Of A New Helipad Using An Iterative Failure Mode And Effects Analysis Framework, Jeffrey A. Holmes, Shelly Chipman, Erin Graydon Baker, Olivia Morejon, Tracie Barbour, Justin Michaud, Michael Baumann, Leah Mallory 2020 Maine Medical Center

Simulation – Based Testing Of A New Helipad Using An Iterative Failure Mode And Effects Analysis Framework, Jeffrey A. Holmes, Shelly Chipman, Erin Graydon Baker, Olivia Morejon, Tracie Barbour, Justin Michaud, Michael Baumann, Leah Mallory

Costas T. Lambrew Research Retreat 2020

Use iterative rounds of simulation and a Failure Mode and Effects Analysis model to detect and mitigate latent safety threats prior to opening a new helicopter landing pad at our hospital.


Meditative And Mind-Body Practice Among Patients With Genitourinary Malignancy, William Daly, Paul Han, Stephen Ryan, Moritz Hansen, Joshua Linscott, Quoc-dien Trinh, Jesse Sammon 2020 Maine Medical Center

Meditative And Mind-Body Practice Among Patients With Genitourinary Malignancy, William Daly, Paul Han, Stephen Ryan, Moritz Hansen, Joshua Linscott, Quoc-Dien Trinh, Jesse Sammon

Costas T. Lambrew Research Retreat 2020

Patients with genitourinary (GU) malignancies like prostate, kidney, and bladder cancer are exposed to many psychosocial stressors associated with cancer diagnosis, treatment and survivorship. The prevalence of anxiety and depression amongst kidney and bladder cancer patients is on par with, and in some studies exceeds, that seen in breast cancer patients. While prostate cancer patients tend to exhibit lower levels of stress when compared to other malignancies, subsets of those patients, especially those with preexisting tendencies towards anxiety, are at higher risk for psychological morbidity than the general population.

Two tools proposed to help patients manage disease specific stressors are ...


Loss Of Spry1 In Vascular Smooth Muscle Cells Promotes Hypercholesterolemiainduced Vsmc Phenotypic Transitions And Regulates Atherogenesis, Xuehui Yang, Shivangi Pande, Robert Friesel 2020 Maine Medical Center

Loss Of Spry1 In Vascular Smooth Muscle Cells Promotes Hypercholesterolemiainduced Vsmc Phenotypic Transitions And Regulates Atherogenesis, Xuehui Yang, Shivangi Pande, Robert Friesel

Costas T. Lambrew Research Retreat 2020

Atherosclerosis is an inflammatory disease characterized by arterial wall thickening and plaque accumulation, and is a major cause of death worldwide. Vascular smooth muscle cells (VSMC), which have the unique ability to transition from mature contractile cells to myofibroblasts and macrophagelike foam cells, and adopt a proinflammatory state contribute to atherogenic microenvironment (1). We aimed to investigate how Spry1, a regulator of receptor tyrosine kinase signaling, affects hypercholesterolemia induced plaque formation in mice by manipulating Spry1 expression specifically in VSMC.


Lean Phenotype Induced By Methionine Restriction In Mice Is Associated With Proteomic Changes In Perivascular Adipose Tissue, Bethany H. Fortier, Calvin PH Vary, Robert A. Koza, Gene P. Ables, Lucy Liaw 2020 Maine Medical Center

Lean Phenotype Induced By Methionine Restriction In Mice Is Associated With Proteomic Changes In Perivascular Adipose Tissue, Bethany H. Fortier, Calvin Ph Vary, Robert A. Koza, Gene P. Ables, Lucy Liaw

Costas T. Lambrew Research Retreat 2020

Perivascular adipose tissue (PVAT) surrounds blood vessels, is thermogenic, and secretes adipokines that can be vasoprotective. During aging and obesity, PVAT loses its thermogenic capacity, shows increased inflammation, and secretes proatherogenic cytokines. Our collaborative research has previously shown that dietary methionine restriction (MetR) in mice can decrease adiposity, improve glucose sensitivity, and induce PVAT to become more thermogenic. To identify initiating signals from PVAT that correspond to thermogenic conversion, we challenged male C57BL/6 mice with a high fat diet (HFD, 60 kcal% fat, 0.86% methionine) until they weighed >45g (~12 weeks of age). Weight matched mice were then ...


Anti-Adipogenicand Cytoprotectiveeffects Of Cthrc1 And Its Potential Role In The Regulation Of Aging, Igor Prudovsky, Matthew Siviski, Doreen Kacer, Yongri Jin, Victoria DeMambro, Patrizio Stohn, Kathleen Pyburn, Rachel Berkovitch, Alaa Makki, Volkhard Lindner 2020 Maine Medical Center

Anti-Adipogenicand Cytoprotectiveeffects Of Cthrc1 And Its Potential Role In The Regulation Of Aging, Igor Prudovsky, Matthew Siviski, Doreen Kacer, Yongri Jin, Victoria Demambro, Patrizio Stohn, Kathleen Pyburn, Rachel Berkovitch, Alaa Makki, Volkhard Lindner

Costas T. Lambrew Research Retreat 2020

actinThe human aging is usually accompanied by sarcopenic obesity and increased sensitivity of tissues to stress factors. The development of approaches promoting healthy versus disease-associated aging should address these issues. CTHRC1 is a secreted protein discovered in Lindner laboratory, based on its enhanced expression in remodeling vessels. Cthrc1 null mice develop abnormalities observed in humans with aging, such as increased body fat, reduced muscle and bone mass, and reduced physical activity. Our in vitro studies have demonstrated that CTHRC1 suppresses adipogenesis by strongly decreasing the expression of pro-adipogenic transcription factors of the CEBP family and enhancing the expression of the ...


Study Strategies For General Surgery Residents Preparing For The Absite: What To Keep, Discard, And Adopt, A Pletch, W Craig, J Rappold, J Whitting, C Turner 2020 Maine Medical Center

Study Strategies For General Surgery Residents Preparing For The Absite: What To Keep, Discard, And Adopt, A Pletch, W Craig, J Rappold, J Whitting, C Turner

Costas T. Lambrew Research Retreat 2020

BACKGROUND: The American Board of Surgery In-Training Examination (ABSITE) is important. Education research regarding general surgery residents is limited, but regarding undergraduate and graduate learners this research is extensive.


Insulin-Like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study And Preliminary Data, A N. Pletch, B Harris, P T. Le, Clifford Rosen 2020 Maine Medical Center

Insulin-Like Growth Factor Binding Protein 2 May Promote Bone Loss After Vertical Sleeve Gastrectomy: A Pilot Study And Preliminary Data, A N. Pletch, B Harris, P T. Le, Clifford Rosen

Costas T. Lambrew Research Retreat 2020

Vertical Sleeve Gastrectomy (VSG) is a successful treatment for obesity; however, one of the unintended consequences is bone loss. The mechanism behind this side effect is unclear. Insulin-like Growth Factor Binding Protein 2 (IGFBP-2) is necessary for osteoclast proliferation and differentiation. It is one of the most highly expressed proteins in human serum after VSG, and its deletion results in resistance to bone loss in mice. We are interested in determining whether IGFBP2 plays a role in the bone loss observed after VSG. • Pilot study: The main objective of the pilot study is to determine which VSG technique is preferred ...


Sclerostin Antibody Normalizes Decreased Trabecular Bone And Increased Bone Marrow Adipose Tissue Caused By Whole-Body Irradiation In Mice, Samantha Costa, Heather Fairfield, Mariah Farrell, Connor Murphy, Ashley Soucy, Gill Holdsworth, Michaela R. Reagan 2020 Maine Medical Center

Sclerostin Antibody Normalizes Decreased Trabecular Bone And Increased Bone Marrow Adipose Tissue Caused By Whole-Body Irradiation In Mice, Samantha Costa, Heather Fairfield, Mariah Farrell, Connor Murphy, Ashley Soucy, Gill Holdsworth, Michaela R. Reagan

Costas T. Lambrew Research Retreat 2020

Irradiation therapy continues to be an accepted medical treatment for many cancers, yet patients are at increased risk for bone deterioration and other skeletal-related events. Irradiation (IR) negatively affects trabecular architecture through increased osteoclast activity and decreased osteoblast activity. Additionally, IR induces increased bone marrow (BM) adipocyte expansion, which may compound IR-induced bone disease. Antibodies to sclerostin (Scl-Ab) increase bone mass and strength by increasing bone formation and reducing bone resorption. We hypothesized Scl-Ab treatment would reverse the adverse effects of IR by increasing bone volume and decreasing BM adipose tissue (BMAT), resulting in improved bone quality. In this study ...


Beyond The Brain: ?-Synuclein And Its Implications In Bone And Fat Metabolism, C A. Figueroa, P Bajgain, C J. Rosen 2020 Maine Medical Center

Beyond The Brain: ?-Synuclein And Its Implications In Bone And Fat Metabolism, C A. Figueroa, P Bajgain, C J. Rosen

Costas T. Lambrew Research Retreat 2020

Introduction: Pathological form of α-synuclein is the major component of the Lewy body in the brain of Parkinson’s disease (PD) patients. Research efforts have been directed towards understanding the root and progression of the neurodegeneration and its association to symptoms. Physiological α-synuclein is ubiquitously present in the human body, however, its role outside the central nervous system has been poorly studied. PD seriously impairs life quality; symptoms comprehend from locomotor dysfunction including resting tremors, rigidity and bradykinesia to non-motor features such as autonomic dysfunction, cognitive/neurobehavioral abnormalities, sleep and sensory disorders. Additionally, PD patients often experiment weight loss, impaired ...


Prrx1-Crealplfl/Flmice, A Model For Further Investigations Into The Pathophysiological Changes In Hypophosphatemia, Victoria DeMambro, Jennifer Daruszka, Daniel Brooks, Mary Bouxsein, Cliff Rosen 2020 Maine Medical Center

Prrx1-Crealplfl/Flmice, A Model For Further Investigations Into The Pathophysiological Changes In Hypophosphatemia, Victoria Demambro, Jennifer Daruszka, Daniel Brooks, Mary Bouxsein, Cliff Rosen

Costas T. Lambrew Research Retreat 2020

Hypophosphatasia (HPP) is caused by loss of function mutations in the tissuenonspecific alkaline phosphatase (TNSALP) gene (Alpl) which results in rickets, osteomalicia and bone fragility with severe childhood forms resulting in lean body mass. TNSALP is a glycosylphosphatidylinositol (GPI)-anchored phosphatase localized at the plasma membrane which when cleaved can also be found in circulation. In vitro, inhibition of TNSALP leads to a significant decrease in lipid accumulation suggesting TNSALP, an enzyme known for its mineralizing properties, may be pro-adipogenic. TNSALP has been implicated in bone marrow mesenchymal stem cell (BMMSC) lineage determination between osteoblasts and adipocytes through direct interactions ...


Primary Cilia-Mediated Ventricular Maturation In Congenital Heart Disease: A Role For Erbb Signaling?, Lindsey A. Fitzsimmons, Sergey Ryzhov, Kerry L. Tucker 2020 Maine Medical Center

Primary Cilia-Mediated Ventricular Maturation In Congenital Heart Disease: A Role For Erbb Signaling?, Lindsey A. Fitzsimmons, Sergey Ryzhov, Kerry L. Tucker

Costas T. Lambrew Research Retreat 2020

The embryonic heart requires a unique, and highly-specialized group of progenitor cells called the cardiac neural crest (CNCC), which are known to contribute specifically to the developing valves, the interventricular septum, and the great vessels of the outflow tract. CNCC display primary cilia, which are tiny, plasma-membrane bound organelles that function to modulate cell signaling mechanisms involved in normal heart development as well as congenital heart disease (CHD). Our laboratory has modeled CNCC-specific ciliary loss, using a Wnt1:Cre-2, Ift88-targeted conditional elimination of primary cilia. Loss of cilia in CNCC of Ift88-homozygous mutants (MUT) was characterized by a variety of ...


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