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Translational Medical Research Commons

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Nkx2-1-As1 Negatively Regulates Cd274/Pd-L1, Cell-Cell Interaction Genes, And Limits Human Lung Carcinoma Cell Migration., Hasmeena Kathuria, Guetchyn Millien, Liam McNally, Adam C. Gower, Jean-Bosco Tagne, Yuxia Cao, Maria I. Ramirez 2018 Boston University School of Medicine

Nkx2-1-As1 Negatively Regulates Cd274/Pd-L1, Cell-Cell Interaction Genes, And Limits Human Lung Carcinoma Cell Migration., Hasmeena Kathuria, Guetchyn Millien, Liam Mcnally, Adam C. Gower, Jean-Bosco Tagne, Yuxia Cao, Maria I. Ramirez

Center for Translational Medicine Faculty Papers

The function of most long noncoding RNAs (lncRNAs) is unknown. However, recent studies reveal important roles of lncRNAs in regulating cancer-related pathways. Human antisense lncRNA-NKX2-1-AS1 partially overlaps the NKX2-1/TTF1 gene within chromosomal region 14q13.3. Amplification of this region and/or differential expression of genes therein are associated with cancer progression. Herein we show higher levels of NKX2-AS1 and NKX2-1 in lung adenocarcinomas relative to non-tumor controls but no correlation between NKX2-1-AS1 and NKX2-1 levels across specimens, or with amplification of the 14q13.3 region, suggesting that NKX2-1-AS1 and NKX2-1 are independently regulated. Loss-and-gain of function experiments showed that ...


Non-St-Segment Elevation Acute Coronary Syndrome: Early Versus Delayed Cardiac Catheterization, Teresa Colelli, Adrianna Clapp, Rudy Wenner, Blake J. Arthurs 2018 Annapolis Family Medicine Residency, Beaumont Wayne Hospital

Non-St-Segment Elevation Acute Coronary Syndrome: Early Versus Delayed Cardiac Catheterization, Teresa Colelli, Adrianna Clapp, Rudy Wenner, Blake J. Arthurs

Clinical Research in Practice: The Journal of Team Hippocrates

An informed consent conversation regarding early vs. delayed cardiac catheterization for patients with NSTEMI.


Editorial: Clinical Practice Can Save Evidence-Based Medicine From Itself, James Peter Meza, Nicholus Yee 2018 Wayne State University School of Medicine

Editorial: Clinical Practice Can Save Evidence-Based Medicine From Itself, James Peter Meza, Nicholus Yee

Clinical Research in Practice: The Journal of Team Hippocrates

Although imperfect, the structure of this journal and its publications are demonstrations of clinicians attempting to actualize the wisdom of these foundational thinkers. We need to leave examples and guideposts to the next generation of clinicians of how to fulfill this vision of being excellent clinicians, through both formal education and role modeling.


Pneumatic Balloon Dilation Versus Myotomy For The Treatment Of Achalsia, Benjamin E. Ueberroth 2018 Wayne State University School of Medicine

Pneumatic Balloon Dilation Versus Myotomy For The Treatment Of Achalsia, Benjamin E. Ueberroth

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Moonen A, Annese V, Belmans A, et al. Long-term results of the European achalasia trial: A multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy. Gut. 2016 May;65(5):732-9. doi: 10.1136/gutjnl-2015-310602.


Fecal Transplant Is Superior To Oral Vancomycin For Treatment Of Recurrent Clostridium Difficile, Kassandra J. Weber 2018 Wayne State University School of Medicine

Fecal Transplant Is Superior To Oral Vancomycin For Treatment Of Recurrent Clostridium Difficile, Kassandra J. Weber

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Van Nood E, Vrieze A, Nieuwdorp M, Fuentes S, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013;368(5):407-415. doi: 10.1056/NEJMoa1205037.


Equal Efficacy Of Clopidogrel Versus Ticagrelor As Monotherapy In Peripheral Artery Disease, Aimee L. Vos 2018 Wayne State University School of Medicine

Equal Efficacy Of Clopidogrel Versus Ticagrelor As Monotherapy In Peripheral Artery Disease, Aimee L. Vos

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Hiatt H, Fowkes G, Heizer G, et al. Ticagrelor versus clopidogrel in symptomatic peripheral artery disease. N Engl J Med. 2017;376:32-40. doi: 10.1056/NEJMoa1611688.


Lurasidone Is Not Associated With Risk Of Qtc Prolongation, Halimah Y. Oral 2018 Wayne State University School of Medicine

Lurasidone Is Not Associated With Risk Of Qtc Prolongation, Halimah Y. Oral

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Meltzer HY, Cucchiaro J, Silva R, Ogasa M, Phillips D, Xu J, Kalali AH, Scheizer E, Pikalov A, Loebel A. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am J Psychiatry. 2011 Sep;168(9):957-67. doi: https://doi.org/10.1176/appi.ajp.2011.10060907.


Long-Term Antibiotic Therapy Is Just As Effective As Amputation For Foot Osteomyelitis In Diabetics Without Peripheral Arterial Disease, Christopher Hopper 2018 Wayne State University School of Medicine

Long-Term Antibiotic Therapy Is Just As Effective As Amputation For Foot Osteomyelitis In Diabetics Without Peripheral Arterial Disease, Christopher Hopper

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Lázaro-Martínez JL, Aragón-Sánchez J, García-Morales E. Antibiotics versus conservative surgery for treating diabetic foot osteomyelitis: a randomized comparative trial. Diabetes Care. 2014;37(3):789-95. doi: 10.2337/dc13-1526.


Ssri Maintenance Therapy Reduces Rate Of Recurrence For Elderly Patients With First Episode Of Major Depression, Blake J. Arthurs 2018 Wayne State University

Ssri Maintenance Therapy Reduces Rate Of Recurrence For Elderly Patients With First Episode Of Major Depression, Blake J. Arthurs

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Reynolds CF 3rd, Dew MA, Pollock BG, et al. Maintenance treatment of major depression in old age. N Engl J Med. 2006 Mar 16;354(11):1130-8. doi: 10.1056/NEJMoa052619. Based on the appraisal, long term SSRI maintenance therapy is recommended for elderly patients suffering from first episode of major depression.


My Patient Chose To Not Use Daily Azithromycin To Prevent Exacerbation Of Copd, Jacob Oblak 2018 Wayne State University School of Medicine

My Patient Chose To Not Use Daily Azithromycin To Prevent Exacerbation Of Copd, Jacob Oblak

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Albert RK, Connett J, Bailey WC, et al. Azithromycin for prevention of exacerbations of COPD. New Eng J Med. 2011;365:689-698. doi: 10.1056/NEJMoa1104623.


Abstinence From Alcohol Improves Survival In Decompensated Cirrhotic Patients, Perry Zong 2018 Wayne State University

Abstinence From Alcohol Improves Survival In Decompensated Cirrhotic Patients, Perry Zong

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Alvarez MA, Cirera I, Solà R, Bargalló A, Morillas RM, Planas R. Long-term clinical course of decompensated alcoholic cirrhosis. Journal of Clinical Gastroenterology. 2011;45(10):906-911. doi: 10.1097/mcg.0b013e3182284e13.


Therapeutic Hypothermia For Children After In-Hospital Cardiac Arrest Not Helpful, Bradley Kolb 2018 Wayne State School of Medicine

Therapeutic Hypothermia For Children After In-Hospital Cardiac Arrest Not Helpful, Bradley Kolb

Clinical Research in Practice: The Journal of Team Hippocrates

An informed consent discussion regarding the merits of therapeutic hypothermia in a comatose pediatric patient following in-hospital cardiac arrest and return of spontaneous circulation.


Institutional Protocols Can Improve Ivc Filter Retrieval Rates, Madeline Ross, Gong He, Veronica Santana-Ufret, Anjali Sundar 2018 Wayne State University School of Medicine

Institutional Protocols Can Improve Ivc Filter Retrieval Rates, Madeline Ross, Gong He, Veronica Santana-Ufret, Anjali Sundar

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Lynch FC. A method for following patients with retrievable inferior vena cava filters: results and lessons learned from the first 1100 patients. J Vasc Interv Radiol. 2011;22:1507–1512. doi: 10.1016/j.jvir.2011.07.019


Pepducin-Mediated Cardioprotection Via Β-Arrestin-Biased Β2-Adrenergic Receptor-Specific Signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio de Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, Douglas G. Tilley 2018 University of Missouri

Pepducin-Mediated Cardioprotection Via Β-Arrestin-Biased Β2-Adrenergic Receptor-Specific Signaling, Laurel A. Grisanti, Toby P. Thomas, Rhonda L. Carter, Claudio De Lucia, Erhe Gao, Walter J. Koch, Jeffrey L. Benovic, Douglas G. Tilley

Department of Biochemistry and Molecular Biology Faculty Papers

Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte death at the time of reperfusion to better preserve function. However, a lack of efficacious βarr-biased orthosteric small molecules has prevented investigation into whether this pathway relays protection against ischemic injury in vivo. We recently demonstrated that the pepducin ICL1-9, a small lipidated peptide fragment designed from the first intracellular loop of β2AR, allosterically engaged pro-survival signaling cascades in a βarr-dependent manner ...


Autologous Blood Patch After Ct-Guided Lung Biopsy Might Reduce Pneumothorax Requiring Chest Tube Placement, Tiffani Strickland 2018 Wayne State University School of Medicine

Autologous Blood Patch After Ct-Guided Lung Biopsy Might Reduce Pneumothorax Requiring Chest Tube Placement, Tiffani Strickland

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Malone LJ, Stanfill RM, Wang H, Fahey KM, Bertino RE. Effect of intraparenchymal blood patch on rates of pneumothorax and pneumothorax requiring chest tube placement after percutaneous lung biopsy. American Journal of Roentgenology. 2013;200(6):1238-1243. doi: 10.2214/ajr.12.8980.


Icatibant Is Not An Appropriate Treatment Option For Ace-Inhibitor Induced Angioedema Of The Head And Neck, Faiz Khaja 2018 Wayne State University School of Medicine

Icatibant Is Not An Appropriate Treatment Option For Ace-Inhibitor Induced Angioedema Of The Head And Neck, Faiz Khaja

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Sinert T, Levy P, Bernstein JA, et al. Randomized trial of icatibant for angiotensin-converting enzyme inhibitor-induced upper airway angioedema. J Allergy Clin Immunol Pract. 2017;5(5):1402-9. doi: 10.1016/j.jaip.2017.03.003


Objective Measurement Of Physical Activity Outcomes In Lifestyle Interventions Among Adults: A Systematic Review, Valerie J. Silfee, Christina Haughton, Danielle E. Jake-Schoffman, Andrea Lopez-Cepero, Christine N. May, Meera Sreedhara, Milagros C. Rosal, Stephanie Lemon 2018 University of Massachusetts Medical School

Objective Measurement Of Physical Activity Outcomes In Lifestyle Interventions Among Adults: A Systematic Review, Valerie J. Silfee, Christina Haughton, Danielle E. Jake-Schoffman, Andrea Lopez-Cepero, Christine N. May, Meera Sreedhara, Milagros C. Rosal, Stephanie Lemon

UMass Center for Clinical and Translational Science Supported Publications

Valid, reliable, and direct measures of physical activity (PA) are critical to assessing the impact of lifestyle PA interventions. However, little is known about the extent to which objective measures have been used to assess the outcomes of lifestyle PA interventions. This systematic review had two aims: 1) evaluate the extent to which PA is measured objectively in lifestyle PA interventions targeting adults and 2) explore and summarize what objective measures have been used and what PA dimensions and metrics have been reported. Pubmed, Cochrane Central Register, and PsychInfo were searched for lifestyle PA interventions conducted between 2006 and 2016 ...


Anidulafungin: A Noninferior Alternative To Fluconazole For Treatment Of Esophageal Candidiasis, Blake S. Sanford 2018 Wayne State University

Anidulafungin: A Noninferior Alternative To Fluconazole For Treatment Of Esophageal Candidiasis, Blake S. Sanford

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Krause DS, Simjee AE, van Rensburg C, et al. A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis. Clin Infect Dis. 2004;39(6):770-775. doi: 10.1086/423378.


Sertraline Is An Effective Management Option For Cholestatic Pruritus, Rudy W. Wenner 2018 Wayne State University School of Medicine

Sertraline Is An Effective Management Option For Cholestatic Pruritus, Rudy W. Wenner

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of Mayo MJ, Handem I, Saldana S, Jacobe H, Getachew Y, Rush AJ. Sertraline as a first-line treatment for cholestatic pruritus. Hepatology. 2007 Mar;45(3):666-74. doi: 10.1002/hep.21553


Intravenous Glucocorticoids Provide No Additional Benefit Over Oral Glucocorticoids In Chronic Obstructive Pulmonary Disease Exacerbation, Alexander C. Waselewski 2018 Wayne State University

Intravenous Glucocorticoids Provide No Additional Benefit Over Oral Glucocorticoids In Chronic Obstructive Pulmonary Disease Exacerbation, Alexander C. Waselewski

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of de Jong YP, Uil SM, Grotjohan HP, Postma DS, Kerstjens HA, van den Berg JW. Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study. Chest. 2007;132(6):1741-1747. doi: 10.1378/chest.07-0208


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