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A Comparison Efficacy Study Of Commercial Nasopharyngeal Swabs Versus A Novel 3d Printed Swab For The Detection Of Sars-Cov-2, Forest W. Arnold, Gerald Grant, Phillip F. Bressoud, Stephen P. Furmanek, Donghoon Chung, Nadine Sbaih, Dipan Karmali, Meredith Cahill, George Pantalos 2020 University of Louisville

A Comparison Efficacy Study Of Commercial Nasopharyngeal Swabs Versus A Novel 3d Printed Swab For The Detection Of Sars-Cov-2, Forest W. Arnold, Gerald Grant, Phillip F. Bressoud, Stephen P. Furmanek, Donghoon Chung, Nadine Sbaih, Dipan Karmali, Meredith Cahill, George Pantalos

The University of Louisville Journal of Respiratory Infections

The large volume of diagnostic tests required by the response to the pandemic of COVID-19 pandemic resulted in a shortage of commercial nasopharyngeal swabs. In an effort to alleviate the shortage, swabs created by 3D printing may be a solution. We designed and produced 3D printed swabs and sought to compare their ability to detect SARS-CoV-2 in patients admitted for COVID-19 or who were suspected of having COVID-19. A total of 30 patients were swabbed with a commercial and printed 3D swab. Results matched in 28 of 31 patients (90%). Two patients were discordant with a positive commercial swab and ...


Treatment-Associated Improvements In Self-Regulation And Mood As Theory-Based Correlates Of Increased Self-Efficacy For Weight-Management Behaviors, James J. Annesi 2020 YMCA of Metropolitan Atlanta; University of Alabama at Birmingham

Treatment-Associated Improvements In Self-Regulation And Mood As Theory-Based Correlates Of Increased Self-Efficacy For Weight-Management Behaviors, James J. Annesi

Health Behavior Research

Expanded understanding of the psychosocial dynamics of weight-loss treatment processes is required to improve consistently poor results. Women with obesity of ages 40–59 years participated in self-regulation-based (n = 41) and information-based (n = 46) treatments. Improvements in self-regulation and self-efficacy related to exercise and eating, mood, exercise, intake of fruits/vegetables and sweets, and weight were significant, and generally greater in the self-regulation group. Exercise- and eating-behavior changes significantly mediated the prediction of self-efficacy changes by changes in self-regulation, with mood change significantly adding to the prediction strength. Findings suggested the value in supporting exercise for its psychosocial benefits within ...


Stroke Management In The Time Of Covid, Marwa Elnazeir, Siddharth Narayanan, Kerri Remmel 2020 Adult Neurology Resident, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA

Stroke Management In The Time Of Covid, Marwa Elnazeir, Siddharth Narayanan, Kerri Remmel

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Covid-19 Radiological Library, Forest W. Arnold, Tracy VanMeter, Lachlan Smith, Danny McGrath, Matthew Grassman, Nishant Patel, William Mattingly 2020 Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY, USA

Covid-19 Radiological Library, Forest W. Arnold, Tracy Vanmeter, Lachlan Smith, Danny Mcgrath, Matthew Grassman, Nishant Patel, William Mattingly

The University of Louisville Journal of Respiratory Infections

No abstract provided.


A Patient With Escherichia Coli Bacteremia And Covid-19 Co-Infection: A Case Report For The Louisville Covid-19 Epidemiology Study, Sarah E. Moore PharmD, Ashley M. Wilde PharmD, BCPS-AQID, Matthew Song PharmD, BCIDP, Brian C. Bohn PharmD, Clayton J. Patross PharmD, BCPS, Bryan Denham MD, Paul Schulz, Julio A. Ramirez 2020 Norton Healthcare

A Patient With Escherichia Coli Bacteremia And Covid-19 Co-Infection: A Case Report For The Louisville Covid-19 Epidemiology Study, Sarah E. Moore Pharmd, Ashley M. Wilde Pharmd, Bcps-Aqid, Matthew Song Pharmd, Bcidp, Brian C. Bohn Pharmd, Clayton J. Patross Pharmd, Bcps, Bryan Denham Md, Paul Schulz, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

Patients with COVID-19 may have co-infections with other microorganisms. Here we report a case of a patient with an E. coli bacteremia secondary to a urinary tract infection, who experienced fevers while on active antimicrobial therapy. The patient was eventually tested for COVID-19 and found to be positive. This case emphasizes the need to suspect COVID-19 even in patients with documented bacterial infection.


Sars-Cov-2 And Bacterial Co-Infection, Rodrigo Cavallazzi 2020 University of Louisville

Sars-Cov-2 And Bacterial Co-Infection, Rodrigo Cavallazzi

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Life In The Time Of Covid, Julio A. Ramirez 2020 University of Louisville

Life In The Time Of Covid, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Healthcare Workers In The Time Of Covid, Julio A. Ramirez, Ruth Carrico 2020 University of Louisville

Healthcare Workers In The Time Of Covid, Julio A. Ramirez, Ruth Carrico

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Abo Blood Group Type And Susceptibility To Covid-19 Infection, G. Rafael Fernandez-Botran 2020 Associate Professor, Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA

Abo Blood Group Type And Susceptibility To Covid-19 Infection, G. Rafael Fernandez-Botran

The University of Louisville Journal of Respiratory Infections

Since December 2019, the SARS-CoV2 (COVID-19) pandemic has continued to extend over most of the world, infecting over four million people and causing well over 300,000 deaths so far (https://coronavirus.jhu.edu/map.html, accessed on May 14, 2020). A significant percentage of infected patients develop severe symptoms and life-threatening conditions. While COVID-19 infection can affect all ages, available evidence points to older age and pre-existing comorbidities such as hypertension, diabetes and coronary heart disease, as important risk factors related to increased mortality rates. [1-3] Moreover, recent reports from China and the U.S. have suggested that the ...


Causes Of Challenges In Implementing Computer-Based Knowledge Management Systems In Healthcare Institutions: A Case Study Of Private Hospitals In Johannesburg, South Africa, George Maramba, Alfred Coleman, Felix F. Ntawanga 2020 UNISA

Causes Of Challenges In Implementing Computer-Based Knowledge Management Systems In Healthcare Institutions: A Case Study Of Private Hospitals In Johannesburg, South Africa, George Maramba, Alfred Coleman, Felix F. Ntawanga

The African Journal of Information Systems

The advent of computer-based knowledge management systems has changed the world, especially in the way businesses operate, making them an integral aspect to modern economies and the drivers of success. Studies show that the implementation of computer-based knowledge management systems is challenging, particularly in healthcare institutions. This paper presents a study that was undertaken to identify the causes of challenges encountered when implementing computer-based knowledge management systems in healthcare institutions. A case was used as this study’s research methodology in which three private hospitals based in Johannesburg, South Africa, were utilized. Six participants, two from each private hospital, were ...


Implementation Of The Louisville Covid-19 Surveillance Protocol: Experiences From The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, Dawn Balcom, William Johnson, Amr Aboelnasr, Mutasem Abuhalaweh, Stephen Furmanek, Montray Smith, Amanda Lasnik, Donghoon Chung, Julio A. Ramirez 2020 University of Louisville Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID)

Implementation Of The Louisville Covid-19 Surveillance Protocol: Experiences From The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, Dawn Balcom, William Johnson, Amr Aboelnasr, Mutasem Abuhalaweh, Stephen Furmanek, Montray Smith, Amanda Lasnik, Donghoon Chung, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

The lack of available testing for SARS-CoV-2 has been one of the primary challenges in the development and implementation of a comprehensive approach to infection prevention and transmission in the United States (US). In response to the need for increased testing capacities and capabilities, the University of Louisville (UofL) Division of Infectious Diseases, Center of Excellence for Research in Infectious Diseases (CERID) initiated the Louisville Coronavirus Surveillance Program, a comprehensive approach to surveillance and testing of patients and healthcare workers. The first specimens were accepted on March 12, 2020 and parallel testing was done using a high-capacity testing process and ...


An Eye On The Dog As The Scientist’S Best Friend For Translational Research In Ophthalmology: Focus On The Ocular Surface, Lionel Sebbag, Jonathan P. Mochel 2020 Iowa State University

An Eye On The Dog As The Scientist’S Best Friend For Translational Research In Ophthalmology: Focus On The Ocular Surface, Lionel Sebbag, Jonathan P. Mochel

Biomedical Sciences Publications

Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (ie., rabbits, mice and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help ...


Variability In Naltrexone Biotransformation, Stephani L. Stancil 2020 Children's Mercy Kansas City

Variability In Naltrexone Biotransformation, Stephani L. Stancil

Research Days

No abstract provided.


Composite Quantitative Knee Structure Metrics Predict The Development Of Accelerated Knee Osteoarthritis: Data From The Osteoarthritis Initiative, Matthew S. Harkey, Julie E. Davis, Lori Lyn. Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Bing Lu, Timothy E. McAlindon, Jeffrey B. Driban 2020 University of Massachusetts Medical School

Composite Quantitative Knee Structure Metrics Predict The Development Of Accelerated Knee Osteoarthritis: Data From The Osteoarthritis Initiative, Matthew S. Harkey, Julie E. Davis, Lori Lyn. Price, Robert J. Ward, James W. Mackay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Bing Lu, Timothy E. Mcalindon, Jeffrey B. Driban

UMass Center for Clinical and Translational Science Supported Publications

BACKGROUND: We aimed to determine if composite structural measures of knee osteoarthritis (KOA) progression on magnetic resonance (MR) imaging can predict the radiographic onset of accelerated knee osteoarthritis.

METHODS: We used data from a nested case-control study among participants from the Osteoarthritis Initiative without radiographic KOA at baseline. Participants were separated into three groups based on radiographic disease progression over 4 years: 1) accelerated (Kellgren-Lawrence grades [KL] 0/1 to 3/4), 2) typical (increase in KL, excluding accelerated osteoarthritis), or 3) no KOA (no change in KL). We assessed tibiofemoral cartilage damage (four regions: medial/lateral tibia/femur), bone ...


A Call For Grounding Implicit Bias Training In Clinical And Translational Frameworks, Nao Hagiwara, Frederick W. Kron, Mark W. Scerbo, Ginger S. Watson 2020 Old Dominion University

A Call For Grounding Implicit Bias Training In Clinical And Translational Frameworks, Nao Hagiwara, Frederick W. Kron, Mark W. Scerbo, Ginger S. Watson

Psychology Faculty Publications

Since the publication of Unequal Treatment in 2003,1 the number of studies investigating the implicit bias of health-care providers and its troubling consequences has increased exponentially. Bias can occur in all three psychological components: affects (ie, prejudice), cognition (ie, stereotypes), and behaviour (ie, discrimination). Implicit bias refers to prejudicial attitudes towards and stereotypical beliefs about a particular social group or members therein. These prejudicial attitudes and stereotypical beliefs are activated spontaneously and effortlessly, which often result in discriminatory behaviours.2 This definition is consistent with how implicit bias is defined in psychology3 and in literature on health disparities ...


Umccts Newsletter, May 2020, UMass Center for Clinical and Translational Science 2020 University of Massachusetts Medical School

Umccts Newsletter, May 2020, Umass Center For Clinical And Translational Science

UMass Center for Clinical and Translational Science Newsletter

This is the May 2020 issue of the UMass Center for Clinical and Translational Science Newsletter containing news and events of interest.


Possible Role Of Tetracyclines On Covid-19: Recycling Well-Known Old Drugs From The Shelf, Martin Gnoni, Raul Vasquez-Gararatti, Angel Mena 2020 University of Louisville; Tri-Health Good Samaritan Hospital; University of Pikeville

Possible Role Of Tetracyclines On Covid-19: Recycling Well-Known Old Drugs From The Shelf, Martin Gnoni, Raul Vasquez-Gararatti, Angel Mena

The University of Louisville Journal of Respiratory Infections

We are in the midst of a pandemic due to the novel coronavirus SARS-CoV-2. Innovative therapies are in the lookup around the world. Recently, chloroquine and hydroxychloroquine in addition to Azithromycin were proposed to be used in patients with severe disease even though strong evidence is lacking. We propose the use of tetracyclines in addition to anti-virals early in the curse of the disease in order to prevent the Cytokine Storm Syndrome associated with COVID-19 and prevent ARDS. The proposed mechanisms of tetracyclines are: 1) anti-apoptotic properties; 2) decrease the Myeloperoxidase and ROS releaser from immune cells; 3) decrease neutrophil ...


Rna Therapeutics: Informational Drugs As A Pandemic Response Tool, Anastasia Khvorova 2020 University of Massachusetts Medical School

Rna Therapeutics: Informational Drugs As A Pandemic Response Tool, Anastasia Khvorova

UMass Center for Clinical and Translational Science Seminars

This presentation, hosted by the Community Engagement and Research Section, University of Massachusetts Medical School Center for Clinical and Translational Science, describes the development of siRNA-based approaches for modulation of COVID-19 in the lung in a three-month time frame.

This talk was the second in the COVID-19 Research Community Forum webinar series, a collaboration of the four federally-funded Clinical and Translational Science Awardees (CTSA) in Massachusetts, that provided an opportunity for community members, institutions and other organizations to be part of the discussions surrounding the COVID-19 pandemic. The MA CTSAs, consisting of the UMass Center for Clinical and Translational Science ...


The Symbiome Project: An Exploratory Investigation Of The Biological, Psychological, And Social Mechanisms That Contribute To The Transition From Acute To Chronic Musculoskeletal Pain, Joshua Y. Lee 2020 The University of Western Ontario

The Symbiome Project: An Exploratory Investigation Of The Biological, Psychological, And Social Mechanisms That Contribute To The Transition From Acute To Chronic Musculoskeletal Pain, Joshua Y. Lee

Electronic Thesis and Dissertation Repository

This dissertation presents the initial findings of the SYMBIOME project; which attempts to combine the objective and subjective aspects of musculoskeletal pain to develop a prognostic clinical phenotype. Chapter 2 presents a moderator analysis of functional outcomes (pain interference and pain severity). Psychosocial moderators can affect the relationship between biomarkers and pain. For pain severity, TNF-α, TGF-β1, and CRP were moderated by employment status, pre-existing psychopathology, and sex. For pain interference, IL-1β, cortisol, TGF-β1, CRP, and IL-6 were moderated by pre-existing pain, peri-traumatic fear, region of injury, and peri-traumatic stress. Chapter 3 presents a latent growth curve analysis in determining ...


How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi k. Kamepalli MD,FIDSA,CWSP 2020 Regional Infectious diseases and infusion ctr,Inc

How Immune T-Cell Augmentation Can Help Prevent Covid-19: A Possible Nutritional Solution Using Ketogenic Lifestyle, Ravi K. Kamepalli Md,Fidsa,Cwsp

The University of Louisville Journal of Respiratory Infections

No abstract provided.


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