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Schizophrenia And Its Effects On An American Family: A Call To Action For The 21st Century, Cynthia Newton Captain 2017 Dominican University of California

Schizophrenia And Its Effects On An American Family: A Call To Action For The 21st Century, Cynthia Newton Captain

Senior Theses and Capstone Projects

Our country’s healthcare system is at a moral crossroads. The way we treat those whom we call “the homeless” is deplorable. The majority of the homeless are mentally ill and need treatment. Our country needs to treat those with the severe brain diseases of schizophrenia, schizo-affective disorder, and bi-polar disorder just as we would Alzheimer’s disease and Parkinson’s disease. Those with severe mental illness, who have no insight into their illness, should not be allowed to dictate their own treatment. If a homeless person is brought to San Francisco General Hospital and is found to be a ...


Inside The Juvenile Justice System, Megan Phalon 2016 University of San Francisco

Inside The Juvenile Justice System, Megan Phalon

Master's Projects

The United States of America is known for freedom and integrity and being a nation that stands for justice and equality for all. Within the United States there are systems in place to better the people and communities in order to provide safety and order. However, just as any nation, there is a struggle with violent behavior and tendencies among adults and adolescents. Within the last three decades, the United States has created a correctional system that specifically targets adolescents, and that acknowledges the differences between adult and juvenile development and deviant behavior. Within this literature review, academic databases were ...


Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot 2016 The Graduate Center, City University of New York

Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Empathy, the ability to both experientially share in and understand others’ thoughts, behaviors, and feelings, is vital for human adaptation. Deficits in empathy development have implications across the lifespan for the development of prosocial behavior, social functioning, mental health disorders, and risk for antisocial behavior (e.g., Guajardo, Snyder, & Petersen, 2009; Moreno, Klute & Robinson, 2008). In light of these societal and individual burdens, it is imperative to foster and strengthen the development of this ability early in life to prevent or ameliorate such negative outcomes. This type of prevention can take a variety of forms, but parent and child verbal exchanges and modeling are often the most direct methods after two years of age (e.g., Moreno et al., 2008). The aim of this research was to inform the development of a system to naturalistically assess empathy development via home-based observation of mothers and their children’s verbal exchanges.

The proposed system, iEAR-Empathy in Parent-Child Interactions (iEAR-EPIC), is a verbal coding system to code for verbal behaviors empirically demonstrated to foster empathy development, as well as behaviors found to indicate empathy development. The development of the iEPIC was theoretically informed by Preston and de Waal’s (2002) Perception Action Mechanism (PAM) model of empathy, a neurocognitive-emotional model of empathy. This model demonstrates empathy as a maturing system in which emotional and cognitive understanding develop in tandem through brain-environment interactions. However, the iEPIC also accounts for the interplay between parents and neurocognitive emotional processes, and thus captures the parallel, increasingly interactive, development of cognitive and emotional abilities from infancy onward in the context of a parent-child dyad.

To develop and test the iEPIC, an ethnically diverse subsample of 84 mothers and their 2 to 6-year-old children were recruited from a large, northeastern, urban, public university. After consenting, mother-child dyads were recorded for a 4-hour period during the dyad’s evening routine (5-9p.m.), using a two-minutes on, 10 seconds off protocol, resulting in 28 2-minute clips (56 minutes total) per dyad. Recordings were transcribed and reviewed, and then 4 pairs of coders were trained in the iEPIC coding system, and then coded the dyad recordings for behaviors comprising the proposed iEPIC assessment system.

The iEPIC observational assessment system consists of 5 codes for each parent and child: Reflection (R), Exploring Emotion and State (EES), Emotion and State Description (ESD), and Empathic Understanding and Concern (EUC), as well as Neutral verbalizations (N; non-study-related verbalizations). The EES, ESD, and EUC each have levels of complexity, with higher levels expected to occur more frequently in older children (e.g., 4 years and older).

There were several purposes of the current study: 1) assess inter-rater reliability for the iEPIC coding system 2) determine if ...


Object Relations In Children's Projective Testing: Applying The Mutuality Of Autonomy Scale To The Thematic Apperception Test, Lily A. Thom 2016 The Graduate Center, City University of New York

Object Relations In Children's Projective Testing: Applying The Mutuality Of Autonomy Scale To The Thematic Apperception Test, Lily A. Thom

All Graduate Works by Year: Dissertations, Theses, and Capstone Projects

Psychodynamic assessment of object relations on projective tests has consistently been shown to contribute to a better understanding of children’s psychological functioning and to guide therapeutic interventions (Tuber, 1992). This research examines the enhanced utility of applying a psychodynamically-derived scale of children’s object relations to a commonly used projective assessment tool, the Thematic Apperception Test (TAT) (Morgan & Murray, 1935; Murray, 1943). The current study investigates the adaptation and application of the Mutuality of Autonomy Scale (MOA) (Urist, 1977; Urist & Shill, 1982), commonly used as a Rorschach Inkblot Method object relations scale, to examine verbal narratives on the TAT. It was hypothesized that findings from the proposed study would demonstrate that the MOA is a readily employable scale for examining children’s object relational paradigms on TAT responses. A second aim of the study was to demonstrate concurrent validity between MOA scores and the Defense Mechanisms Manual (DMM), a well-validated tool for assessing developmental level of defenses on the TAT (Cramer, 1991). In addition, this work contributes to the need for empirically-validated, systematic approaches to interpreting TAT data (Rossini & Moretti, 1997; Cramer, 2004). The findings showed several expected, significant relationships between level of defense and object relations that confirmed the study’s ...


Metabolic Alterations In Experimental Models Of Depression, Maria G. Puiu, Mihnea C. Manea, George L. Paraschiv, Traian Purnichi, Ecaterina Ionescu, Simona Tache, Ioana Paunica, Mirela Manea 2016 Carol Davila University of Medicine and Pharmacy, Deparment of Psychiatry and Psychology

Metabolic Alterations In Experimental Models Of Depression, Maria G. Puiu, Mihnea C. Manea, George L. Paraschiv, Traian Purnichi, Ecaterina Ionescu, Simona Tache, Ioana Paunica, Mirela Manea

Journal of Mind and Medical Sciences

Introduction: Major depressive disorder is one of the most prevalent psychiatric disorders and is associated with a severe impact on the personal functioning, thus with incurring significant direct and indirect costs. The presence of depression in patients with medical comorbidities increases the risks of myocardial infarction and decreases diabetes control, and adherence to treatment. The mechanism through which these effects are produced is still uncertain. Objectives of this study were to evaluate the metabolic alterations in female Wistar rats with induced depression, with and without administration of Agomelatine. The methods included two experiments. All data were analyzed by comparison with ...


Structural Dichotomy Of The Mind; The Role Of Sexual Neuromodulators, Ion G. Motofei, David L. Rowland 2016 Carol Davila University, Department of Surgery and Psychiatry

Structural Dichotomy Of The Mind; The Role Of Sexual Neuromodulators, Ion G. Motofei, David L. Rowland

Journal of Mind and Medical Sciences

The mind (mental function) and sexuality represent two distinct environmental functions, but which are supported within the brain by a common (somatic-autonomic) neurobiological substrate. As a consequence, mental function takes on autonomic characteristics from the sexual-autonomic system (like autonomy, duality), while sexual function takes on features from mental functioning (such as lateralization). In this paper we discuss the lateralized action of two classes of sexual neuromodulators: hormones and pheromones. This process of lateralization is assimilated with the structural dichotomy of the mind.

A relatively similar process but related to informational dichotomy of the mind will be presented in a forthcoming ...


The Current Treatment Of Erectile Dysfunction, Maria Isabela Sarbu, Mircea Tampa, Mădălina I. Mitran, Cristina I. Mitran, Vasile Benea, Simona R. Georgescu 2016 Carol Davila University, Department of Dermatology and Venereology

The Current Treatment Of Erectile Dysfunction, Maria Isabela Sarbu, Mircea Tampa, Mădălina I. Mitran, Cristina I. Mitran, Vasile Benea, Simona R. Georgescu

Journal of Mind and Medical Sciences

Erectile dysfunction (ED) is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. It is the most frequent sexual dysfunction in elderly men and its prevalence increases with age.

Ever since ED was recognized as a real health problem, several treatment options became available and some of them proved to be very efficient. PDE5 inhibitors are the mainstay treatment of ED.

However, other treatment options such as intracorporal injections, surgery, vacuum devices and prosthesis are also available for patients who are unresponsive to PDE5 inhibitors. Since none of the treatment options available so far has proven ...


The Substrate Of The Biopsychosocial Influences In The Carcinogenesis Of The Digestive Tract, Georgică C. Târtea, Cristina Florescu, Daniel Pirici, Daniel Caragea, Elena A. Târtea, Cristin C. Vere 2016 Cardiology Resident Doctor, PhD Student Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania

The Substrate Of The Biopsychosocial Influences In The Carcinogenesis Of The Digestive Tract, Georgică C. Târtea, Cristina Florescu, Daniel Pirici, Daniel Caragea, Elena A. Târtea, Cristin C. Vere

Journal of Mind and Medical Sciences

Digestive cancer represents a severe public health problem, being one of the main causes of death. It is considered a multifactorial disease, with hereditary predisposition, environmental factors, and other factors involved in carcinogenesis. Both the evolution and the pathogenesis of digestive neoplasms remain incompletely elucidated. As a multifactorial disease, it can be approached by taking into account the biopsychosocial influences via enteric nervous system. Many peptides and non-peptides having a neurotransmitter role can be found in the enteric nervous system, which can influence the neoplastic process directly or indirectly by affecting some angiogenic, growth, and metastasis factors. However, neurotransmitters can ...


The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică 2016 Valparaiso University, Department of Psychology

The Postfinasteride Syndrome; An Overview, David L. Rowland, Ion G. Motofei, Florian Popa, Vlad D. Constantin, Adriana Vasilache, Ioana Păunică, Cristian Bălălău, Georgeta P. Păunică, Petrisor Banu, Stana Păunică

Journal of Mind and Medical Sciences

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.”

Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse ...


Mission Diversion & Recovery For Traumatized Veterans (Mission Direct Vet): Early Findings And Lessons Learned, Paul P. Christopher, Elizabeth A. Aaker, Amanda Lennox, William H. Fisher, Carl E. Fulwiler, Stephanie W. Hartwell, David Smelson, Debra A. Pinals 2016 University of Massachusetts Medical School

Mission Diversion & Recovery For Traumatized Veterans (Mission Direct Vet): Early Findings And Lessons Learned, Paul P. Christopher, Elizabeth A. Aaker, Amanda Lennox, William H. Fisher, Carl E. Fulwiler, Stephanie W. Hartwell, David Smelson, Debra A. Pinals

Stephanie W. Hartwell

MISSION DIRECT VET is a SAMHSA- funded, court based diversion program targeting veterans in Massachusetts with trauma-related mental health and substance use problems. MISSION-DIRECT VET seeks to: Reduce criminal justice involvement Treat mental health, substance abuse and other trauma related symptoms Use a systematic wrap-around model Provide care coordination, peer support and trauma informed services Develop interagency partnerships to serve veterans with co-occurring disorders


Mission Diversion & Recovery For Traumatized Veterans (Mission Direct Vet): Early Planning And Development, Paul P. Christopher, William H. Fisher, Mary Ellen G. Foti, Carl E. Fulwiler, Albert J. Grudzinskas, Stephanie W. Hartwell, David Smelson, Debra A. Pinals 2016 University of Massachusetts Medical School

Mission Diversion & Recovery For Traumatized Veterans (Mission Direct Vet): Early Planning And Development, Paul P. Christopher, William H. Fisher, Mary Ellen G. Foti, Carl E. Fulwiler, Albert J. Grudzinskas, Stephanie W. Hartwell, David Smelson, Debra A. Pinals

Stephanie W. Hartwell

MISSION DIRECT VET is a SAMHSA- funded, court based diversion program targeting veterans in Massachusetts with trauma-related mental health and substance use problems. MISSION-DIRECT VET seeks to: Reduce criminal justice involvement Treat mental health, substance abuse and other trauma related symptoms Use a systematic wrap-around model Provide care coordination, peer support and trauma informed service.


Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston 2016 University of Massachusetts Medical School

Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston

Stephenie C. Lemon

BACKGROUND: What is the next frontier for computer-tailored health communication (CTHC) research? In current CTHC systems, study designers who have expertise in behavioral theory and mapping theory into CTHC systems select the variables and develop the rules that specify how the content should be tailored, based on their knowledge of the targeted population, the literature, and health behavior theories. In collective-intelligence recommender systems (hereafter recommender systems) used by Web 2.0 companies (eg, Netflix and Amazon), machine learning algorithms combine user profiles and continuous feedback ratings of content (from themselves and other users) to empirically tailor content. Augmenting current theory-based ...


Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston 2016 University of Massachusetts Medical School

Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston

Kathleen M. Mazor

BACKGROUND: What is the next frontier for computer-tailored health communication (CTHC) research? In current CTHC systems, study designers who have expertise in behavioral theory and mapping theory into CTHC systems select the variables and develop the rules that specify how the content should be tailored, based on their knowledge of the targeted population, the literature, and health behavior theories. In collective-intelligence recommender systems (hereafter recommender systems) used by Web 2.0 companies (eg, Netflix and Amazon), machine learning algorithms combine user profiles and continuous feedback ratings of content (from themselves and other users) to empirically tailor content. Augmenting current theory-based ...


Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston 2016 University of Massachusetts Medical School

Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston

Sarah L. Cutrona

BACKGROUND: What is the next frontier for computer-tailored health communication (CTHC) research? In current CTHC systems, study designers who have expertise in behavioral theory and mapping theory into CTHC systems select the variables and develop the rules that specify how the content should be tailored, based on their knowledge of the targeted population, the literature, and health behavior theories. In collective-intelligence recommender systems (hereafter recommender systems) used by Web 2.0 companies (eg, Netflix and Amazon), machine learning algorithms combine user profiles and continuous feedback ratings of content (from themselves and other users) to empirically tailor content. Augmenting current theory-based ...


Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston 2016 University of Massachusetts Medical School

Collective-Intelligence Recommender Systems: Advancing Computer Tailoring For Health Behavior Change Into The 21st Century, Rajani S. Sadasivam, Sarah L. Cutrona, Rebecca L. Kinney, Benjamin M. Marlin, Kathleen M. Mazor, Stephenie C. Lemon, Thomas K. Houston

Rajani S. Sadasivam

BACKGROUND: What is the next frontier for computer-tailored health communication (CTHC) research? In current CTHC systems, study designers who have expertise in behavioral theory and mapping theory into CTHC systems select the variables and develop the rules that specify how the content should be tailored, based on their knowledge of the targeted population, the literature, and health behavior theories. In collective-intelligence recommender systems (hereafter recommender systems) used by Web 2.0 companies (eg, Netflix and Amazon), machine learning algorithms combine user profiles and continuous feedback ratings of content (from themselves and other users) to empirically tailor content. Augmenting current theory-based ...


Two Distinct Patterns Of Treatment Resistance: Clinical Predictors Of Treatment Resistance In First-Episode Schizophrenia Spectrum Psychoses., John Lally, O Ajnakina, M Di Forti, A Trotta, A Demjaha, A Kolliakou, V Mondelli, T Reis Marques, C Pariante, P Dazzan, S S. Shergil, O D. Howes, A S. David, J H. MacCabe, F Gaughran, R M. Murray 2016 Royal College of Surgeons in Ireland

Two Distinct Patterns Of Treatment Resistance: Clinical Predictors Of Treatment Resistance In First-Episode Schizophrenia Spectrum Psychoses., John Lally, O Ajnakina, M Di Forti, A Trotta, A Demjaha, A Kolliakou, V Mondelli, T Reis Marques, C Pariante, P Dazzan, S S. Shergil, O D. Howes, A S. David, J H. Maccabe, F Gaughran, R M. Murray

Psychiatry Articles

BACKGROUND: Clozapine remains the only evidence-based antipsychotic for treatment-resistant schizophrenia (TRS). The ability to predict which patients with their first onset of schizophrenia would subsequently meet criteria for treatment resistance (TR) could help to diminish the severe functional disability which may ensue if TR is not recognized and correctly treated.

METHOD: This is a 5-year longitudinal assessment of clinical outcomes in a cohort of 246 first-episode schizophrenia spectrum patients recruited as part of the NIHR Genetics and Psychosis (GAP) study conducted in South London from 2005 to 2010. We examined the relationship between baseline demographic and clinical measures and the ...


Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori 2016 Humana, Inc.

Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamthoori

Amy B. Wachholtz

BACKGROUND: There are many studies in the literature on the association between depression treatment and health expenditures. However, there is a knowledge gap in examining this relationship taking into account coexisting chronic conditions among patients with diabetes. We aim to analyze the association between depression treatment and healthcare expenditures among adults with Type 2 Diabetes Mellitus (T2DM) and newly-diagnosed depression, with consideration of coexisting chronic physical conditions.

METHODS: We used multi-state Medicaid data (2000-2008) and adopted a retrospective longitudinal cohort design. Medical conditions were identified using diagnosis codes (ICD-9-CM and CPT systems). Healthcare expenditures were aggregated for each month for ...


Visual Perception And Processing In Children With 22q11.2 Deletion Syndrome: Associations With Social Cognition Measures Of Face Identity And Emotion Recognition., Kathryn L. McCabe, Stuart Marlin, Gavin Cooper, Robin Morris, Ulrich Schall, Declan G. Murphy, Kieran C. Murphy, Linda E. Campbell 2016 The University of Newcastle, Australia

Visual Perception And Processing In Children With 22q11.2 Deletion Syndrome: Associations With Social Cognition Measures Of Face Identity And Emotion Recognition., Kathryn L. Mccabe, Stuart Marlin, Gavin Cooper, Robin Morris, Ulrich Schall, Declan G. Murphy, Kieran C. Murphy, Linda E. Campbell

Psychiatry Articles

BACKGROUND: People with 22q11.2 deletion syndrome (22q11DS) have difficulty processing social information including facial identity and emotion processing. However, difficulties with visual and attentional processes may play a role in difficulties observed with these social cognitive skills.

METHODS: A cross-sectional study investigated visual perception and processing as well as facial processing abilities in a group of 49 children and adolescents with 22q11DS and 30 age and socio-economic status-matched healthy sibling controls using the Birmingham Object Recognition Battery and face processing sub-tests from the MRC face processing skills battery.

RESULTS: The 22q11DS group demonstrated poorer performance on all measures of ...


Muscle Dysmorphia And Athletic Identity, Taylor McGohan 2016 Western Kentucky University

Muscle Dysmorphia And Athletic Identity, Taylor Mcgohan

Honors College Capstone Experience/Thesis Projects

Society is creating a stronger importance for men to have muscular physiques. Therefore, increasing the dissatisfaction men have with their bodies and perceptions of body image. The current study assesses the possible relationship between muscle dysmorphia and athletic identity. As well as a relationship between lifting time and athletic identity. Participants for the current study took three different self-reported surveys to measure demographics, exercise history, level of athletic identity, and possible symptoms of muscle dysmorphia. It was hypothesized that those with strong athletic identities also have a stronger desire to gain muscle mass, increasing likelihood of displaying muscle dysmorphia symptoms ...


Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad 2016 The University of Western Ontario

Cal And Magi Pdz Protein Regulation Of Crfr1 And 5-Ht2ar Trafficking And Signaling, Maha Mahmoud Hammad

Electronic Thesis and Dissertation Repository

PDZ (PSD95/Disc Large/Zona Occludens) domain-containing proteins are scaffolding proteins that play important roles in regulating the activity of G protein-coupled receptors. Corticotropin Releasing Factor Receptor 1 (CRFR1) and Serotonin 2A Receptor (5-HT2AR) are two GPCRs that are commonly associated with mental disorders. Both receptors also contain a class I PDZ-binding motif at the carboxyl terminal tail. In the first chapter, we investigate the effects of CAL (CFTR-associated ligand) on regulating the trafficking and signaling of CRFR1. We demonstrate a role for CAL in inhibiting CRFR1 endocytosis, cell surface expression, and CRF-mediated ERK1/2 signaling via the ...


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