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Characterizing The Response Of Multidrug-Resistant Klebsiella Pneumoniae Species To The Application Of A Phage Cocktail, Steven Liu 2014 California Polytechnic State University

Characterizing The Response Of Multidrug-Resistant Klebsiella Pneumoniae Species To The Application Of A Phage Cocktail, Steven Liu

Symposium

Project Summary: The application of bacteriophages to treat bacterial infections is known as phage therapy, which takes advantage of bacteriophage’s natural ability to infect and lyse bacterial hosts. Phages have been shaped by billions of years of evolution to be highly specialized deliverers of bactericidal agents to the cytoplasm of their target bacteria. Ever since discovery of bacteriophages in 1915, phage therapy was recognized as a potentially powerful tool for eliminating bacterial infections. The effectiveness of phage therapy can be increased by creating a mixture of multiple phages to target a wider variety of bacterial strains. Furthermore, phage therapy ...


Informed Consent, Psychotropic Medications, And A Prescribing Physician’S Duty To Disclose Safer Alternative Treatments, Rita F. Barnett Ms. 2014 Chapman University Dale E. Fowler School of Law

Informed Consent, Psychotropic Medications, And A Prescribing Physician’S Duty To Disclose Safer Alternative Treatments, Rita F. Barnett Ms.

Rita Barnett

INFORMED CONSENT, PSYCHOTROPIC MEDICATIONS, AND A PRESCRIBING PHYSICIAN’S DUTY TO DISCLOSE SAFER ALTERNATIVE TREATMENTS

The use of psychotropic medication to treat any presumed mental health disorder always involves serious risks of harm. Accordingly, before prescribing psychotropic medication to control the behaviors associated with a presumed mental health disorder, prescribing physicians are required, under various medical ethical guidelines and informed consent laws, to first disclose information regarding available alternative treatment options, and the risks and benefits of such alternative treatment options. Indeed, because psychotropic medications are themselves experimental treatments due to the concededly unknown etiology of most mental health disorders ...


The Use Of Natural Products As Potential Anti-Pseudomonas Agents, Margaret T. Bell 2014 Seton Hall University

The Use Of Natural Products As Potential Anti-Pseudomonas Agents, Margaret T. Bell

Seton Hall University Dissertations and Theses (ETDs)

Pseudomonas is a genus of gram-negative gammaproteobacteria with a large range of diversity. Because of its ability to grow at low temperature, Pseudomonas is a cause of food spoilage. This bacterium is also a very common nosocomial infection of hospital patients. In this study, we investigated the effects of different natural products on Pseudomonas. The products included a polysaccharide, two flavonoids tangeretin and nobiletin and their derivatives, 5’OH-tangeretin and 5’OH-nobiletin, black tea polyphenol – theaflavins (TFs), as well as an herb named Fallopia multiflora (Chinese Knotweed). P. fluorescens and P. aeruginosa were used as model organisms. Antimicrobial effects were ...


Herbal And Holistic Medicine In Latin America, William H. Lyle 2014 Western Kentucky University

Herbal And Holistic Medicine In Latin America, William H. Lyle

Honors College Capstone Experience/Thesis Projects

A variety of herbal and holistic remedies were used in pre-Columbian cultures, especially in Aztec and Incan cultures. Many different herbs were used to provide medical attention to patients directly, while other herbs were used to supplement shaman[1] medicine, which was particularly common in Inca culture. While there is little scientific basis for shamanism, as a viable healing option in modern culture, most herbal remedies had active chemical ingredients that could be or are used today to treat similar symptoms, and, in some cases, are being applied in different scenarios as well. The methods of usage, active chemicals, and ...


The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn 2014 University of Connecticut

The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn

Honors Scholar Theses

Substantial evidence has shown that dopamine (DA), particularly in the nucleus accumbens (NAc), is involved in behavioral activation and effort-related processes, such as overcoming work related response costs. Interference with accumbens DA transmission through administration of the vesicular monoamine transportor-2 (VMAT-2) inhibitor tetrabenazine (TBZ) produces an alteration of response allocation in the concurrent FR5/chow choice procedure, biasing animals toward the lower effort alternative. It has been suggested that these drug-induced shifts in effort-related choice behavior seen in rodents are analogous to symptoms such as psychomotor retardation, anergia, and fatigue, which can be observed in people with depression and other ...


Cultural Competency In The Medical Workplace: A Look At Outpatient Clinic Nurses At A Children's Hospital In New England, Evelyn S. Callahan 2014 University of Connecticut

Cultural Competency In The Medical Workplace: A Look At Outpatient Clinic Nurses At A Children's Hospital In New England, Evelyn S. Callahan

Honors Scholar Theses

This paper analyzes the current state of progress toward cultural competency in the medical workplace, specifically in the hospital setting. It compares the current writing on the topic to research done at a large New England children’s hospital. The nurses are all individuals who work in an out patient setting so they often see the same patients regularly for longer periods of time. This differs from the in-patient or floor nurses who only spend limited time with a constantly changing population of patients. The research involved one-on-one interviews and a focus group with nurses at the hospital. The focus ...


Effect Of Ascorbate On Coagulation And Fibrinolytic Factors In The Septic Microvasculature, Scott Swarbreck 2014 Western University

Effect Of Ascorbate On Coagulation And Fibrinolytic Factors In The Septic Microvasculature, Scott Swarbreck

University of Western Ontario - Electronic Thesis and Dissertation Repository

Sepsis, a systemic inflammatory response to an infection, is a significant cause of morbidity and mortality worldwide. The microcirculation during sepsis fails, in part, due to microthrombosis and the resulting plugging of capillaries, precipitating organ failure. Intravenous injection of ascorbate has been shown to reduce capillary plugging, however the mechanism of this protective effect is unclear. We hypothesized that ascorbate-mediated destabilization of the microthrombi through promoting fibrinolysis could contribute to this protection.

We showed that streptokinase, a pro-fibrinolytic agent, reduced the capillary plugging to a similar degree as ascorbate. This similarity provided the impetus for studying the effect of ascorbate ...


Can Ginger Ameliorate Chemotherapy-Induced Nausea? Protocol Of A Randomized Double Blind, Placebo-Controlled Trial, Wolfgang Marx, A McCarthy, Karin Reid, Luis Vitetta, D McKavanagh, Damien Thomson, Avni Sali, Elizabeth Isenring 2014 Bond University

Can Ginger Ameliorate Chemotherapy-Induced Nausea? Protocol Of A Randomized Double Blind, Placebo-Controlled Trial, Wolfgang Marx, A Mccarthy, Karin Reid, Luis Vitetta, D Mckavanagh, Damien Thomson, Avni Sali, Elizabeth Isenring

Faculty of Health Sciences & Medicine Publications

Background: Preliminary research shows ginger may be an effective adjuvant treatment for chemotherapy-induced nausea and vomiting but significant limitations need to be addressed before recommendations for clinical practice can be made. Methods/Design: In a double–blinded randomised-controlled trial, chemotherapy-naïve patients will be randomly allocated to receive either 1.2 g of a standardised ginger extract or placebo per day. The study medication will be administrated as an adjuvant treatment to standard anti-emetic therapy and will be divided into four capsules per day, to be consumed approximately every 4 hours (300 mg per capsule administered q.i.d) for five ...


Enacting Kaitiakitanga: Challenges And Complexities In The Governance And Ownership Of Rongoā Research Information, Amohia Boulton, Maui Hudson, Annabel Ahuriri-Driscoll, Albert Stewart 2014 Western University

Enacting Kaitiakitanga: Challenges And Complexities In The Governance And Ownership Of Rongoā Research Information, Amohia Boulton, Maui Hudson, Annabel Ahuriri-Driscoll, Albert Stewart

The International Indigenous Policy Journal

This article explores the tensions one research team has faced in securing appropriate governance or stewardship (which we refer to as kaitiakitanga) of research data. Whilst ethical and regulatory frameworks exist which provide a minimum standard for researchers to meet when working with Māori, what our experience has highlighted is there is currently a “governance” gap in terms of who should hold stewardship of research data collected from Māori individuals or collectives. In the case of a project undertaken in the traditional healing space, the organisation best placed to fulfil this governance role receives no funding or support to take ...


The Effects Of Osteopathic Treatment On Common Femoral Artery Blood Flow And Skin Temperature In Spinal Cord Injured And Able-Bodied Individuals, David J.G. Murray 2014 McMaster University

The Effects Of Osteopathic Treatment On Common Femoral Artery Blood Flow And Skin Temperature In Spinal Cord Injured And Able-Bodied Individuals, David J.G. Murray

Open Access Dissertations and Theses

ABSTRACT

Individuals with spinal cord injuries (SCI) are prone to significant alterations in vascular structure and function. This study was designed to examine the effects of osteopathic treatment on mean leg (MLBF) blood flow and skin temperature in the lower extremities of individuals with chronic SCI compared to able-bodied (AB) individuals. Methods: Nine individuals (age 44 ± 17.5 years) with a chronic SCI (C6-T12; AIS A-B; 3.7 ± 4.6 years post-injury) and six AB individuals (38.3 ± 9.7 years) participated. The protocol consisted of 1 interview session and 3 osteopathic treatment sessions. Doppler ultrasound measured the diameter and ...


The Effect Of Blue Light On Pilot And Flight Attendant Behavioral Alertness, Lori J. Brown, Toine Schoutens, Geoffrey Whitehurst, Troy Booker, Travis Davis, Spencer Losinski, Ryan Diehl 2014 Western Michigan University

The Effect Of Blue Light On Pilot And Flight Attendant Behavioral Alertness, Lori J. Brown, Toine Schoutens, Geoffrey Whitehurst, Troy Booker, Travis Davis, Spencer Losinski, Ryan Diehl

Lori J. Brown

The study aimed to investigate the efficacy of blue light therapy to improve behavioral alertness in flight crew-members. Western Michigan University, College of Aviation, Jeppesen (a Boeing Company), Nature Bright Company, Airline participants, and a leading sleep researcher Schoutens, A.M.C. of FluxPlus, BV, The Netherlands, collaborated to examine whether timed blue light could improve flight crewmember alertness. During the four week study, crewmembers wore actigraph bands to monitor sleep behaviors. Self-assessed levels of sleepiness were recorded using the Karlosinska Sleepiness Scale (KSS), and self-assessed fatigue was measured using the Samn-Perelli (SP) fatigue scale. Participants completed psychomotor vigilance tests ...


Is Hyperbaric Oxygen Therapy An Effective Treatment For Autism? A Review, Daniel Dunleavy, Bruce A. Thyer 2014 University of Tennessee at Chattanooga

Is Hyperbaric Oxygen Therapy An Effective Treatment For Autism? A Review, Daniel Dunleavy, Bruce A. Thyer

Journal of Adolescent and Family Health

Objectives: We review outcome studies regarding the effectiveness of hyperbaric oxygen therapy (HBOT) for Autism Spectrum Disorders (ASD). Method: Studies were identified through electronic bibliographic databases and manual searches of article reference lists. Results: A total of 8 studies met eligibility criteria, consisting of three randomized controlled trials (RCTs), one quasi-experimental study involving a comparison group, two pre-experimental one-group pretest–posttest studies, and two single-system designs. Studies reviewed did not offer credible evidence to suggest that HBOT is an effective treatment for autism. Conclusion: It is premature to call HBOT an effective treatment for Autism and ASD. Individuals clinically treated ...


Traditional Elders In Post-Secondary Stem Education, Maria Pontes Ferreira, Betty McKenna, Fidji Gendron 2014 Wayne State University

Traditional Elders In Post-Secondary Stem Education, Maria Pontes Ferreira, Betty Mckenna, Fidji Gendron

Nutrition and Food Science Faculty Research Publications

Native/Aboriginal students are underrepresented in Western science, technology, engineering, and mathematics (STEM), due in part to perceived cultural irrelevance. Yet many Native people continue to engage in Indigenous science, such as through traditional medicine and food systems. Recently it was shown that Aboriginal university students are significant users of natural health products (NHP) and learn about NHP from Elders. Thus, in post-secondary educational settings, the presence of Elders may positively impact Native students' interest in science-related topics. At the First Nations University of Canada, partnering of STEM-trained faculty with Elders occurs in community-based research and education endeavours. This paper ...


Animal-Assisted Therapy: Motives And Rewards, Kailee Victoria Collins 2014 University of New Hampshire

Animal-Assisted Therapy: Motives And Rewards, Kailee Victoria Collins

Honors Theses

Animal-assisted therapy is a complimentary therapy utilized in health care to provide goal-directed therapy using dogs. The purpose of this study was to understand what motivates individuals to being animal-assisted volunteering and rewards that encourage and sustain animal-assisted volunteering. This mixed methods study employed quantitative methods, a demographic questionnaire and the Volunteer Motivation Index (VMI), which ranks motives most important to animal-assisted volunteers (N=15) and qualitative methods, a semi-structured interview (N=13). The participants ranked Values most important as a motive on the VMI. Social related variables were ranked low. Content analysis of the interviews yielded five themes: No ...


Music Therapy For Patients Who Have Undergone Hematopoietic Stem Cell Transplant, Chelsea G. Ratcliff, Sara Prinsloo, Michael Richardson, Laura Baynham-Fletcher, Richard Lee, Alejandro Chaoul, Marlene Z. Cohen, Marcos de Lima, Lorenzo Cohen 2014 University of Nebraska Medical Center

Music Therapy For Patients Who Have Undergone Hematopoietic Stem Cell Transplant, Chelsea G. Ratcliff, Sara Prinsloo, Michael Richardson, Laura Baynham-Fletcher, Richard Lee, Alejandro Chaoul, Marlene Z. Cohen, Marcos De Lima, Lorenzo Cohen

Journal Articles: College of Nursing

Objectives. This study examines the short- and long-term QOL benefits of a music therapy intervention for patients recovering from hematopoietic stem cell transplantation (HSCT). Methods. Ninety allogeneic HSCT patients, after transplant, were randomized to receive ISO-principle (i.e., mood matching) based music therapy (MT; n = 29), unstructured music (UM; n = 30), or usual care (UC; n = 31) for four weeks. The ISO principle posits that patients may shift their mood from one state to another by listening to music that is "equal to" the individual's initial mood state and subsequently listening to music selections that gradually shift in tempo ...


Short-Term Effectiveness Of A Lifestyle Intervention Program For Reducing Selected Chronic Disease Risk Factors In Individuals Living In Rural Appalachia: A Pilot Cohort Study, David Drozek, Hans Diehl, Masato Nakazawa, Tom Kostohryz, Darren Morton, Jay Shubrook 2014 Avondale College

Short-Term Effectiveness Of A Lifestyle Intervention Program For Reducing Selected Chronic Disease Risk Factors In Individuals Living In Rural Appalachia: A Pilot Cohort Study, David Drozek, Hans Diehl, Masato Nakazawa, Tom Kostohryz, Darren Morton, Jay Shubrook

Education Papers and Journal Articles

Most Western chronic diseases are closely tied to lifestyle behaviors, and many are preventable. Despite the well-distributed knowledge of these detrimental behaviors, effective efforts in disease prevention have been lacking. Many of these chronic diseases are related to obesity and type " diabetes, which have doubled in incidence during the last 35 years. The Complete Health Improvement Program (CHIP) is a community-based, comprehensive lifestyle modification approach to health that has shown success in addressing this problem. This pilot study demonstrates the effectiveness of CHIP in an underserved, rural, and vulnerable Appalachian population. Two hundred fourteen participants in CHIP collectively demonstrated significant ...


Cura Personalis: A Healthcare Delivery Quandary At The End Of Life, George P. Smith II 2014 The Catholic University of America, Columbus School of Law

Cura Personalis: A Healthcare Delivery Quandary At The End Of Life, George P. Smith Ii

Scholarly Articles and Other Contributions

Holistic Medicine traces its provenance to the foundational value or chrism of the Society of Jesus of cura personalis which directs respect be given to all individuals and to their souls — especially whenever medical healing is required. Today, the notion of best patient care should include not merely attention to somatic issues of refractory pain management but, equally, to non-somatic or existential suffering. It is at the end-stage of life that palliative — as opposed to curative — care must be provided. When a condition is seen as medically futile, this Article advocates palliative or deep sedation — when consistent with patient values ...


Modern Cavemen? Stereotypes And Reality Of The Ancestral Health Movement, David B. Schwartz, Hamilton M. Stapell 2013 Ancestral Health Society

Modern Cavemen? Stereotypes And Reality Of The Ancestral Health Movement, David B. Schwartz, Hamilton M. Stapell

Journal of Evolution and Health

Both academic and popular interest in the ancestral health movement, or “paleo” lifestyle, has grown rapidly in recent years. More people than ever are joining the movement, and more books and articles are being published on the topic. Media coverage and certain societal preconceptions of the movement have also increased. More often than not, followers of a paleo lifestyle are thought to be “modern cavemen”: athletic, single, meat-eating, young, white, and male. To test whether or not these stereotypes are true, the authors of the present study created the first large, academic survey (N = 3,967) of the ancestral health ...


Medicine And Doctoring In Ancient Mesopotamia, Emily K. Teall 2013 Grand Valley State University

Medicine And Doctoring In Ancient Mesopotamia, Emily K. Teall

Grand Valley Journal of History

Medicine and pharmaceuticals in Mesopotamia during the span of c. 3000-1000 BCE were more sophisticated than many ancient and modern scholars from other cultures would concede. The limited historical evidence in the form of cuneiform texts and the complementary archaeological material allow for medical practice in this long time span to be examined as a whole. There were two dichotomous traditions of healing present in ancient Mesopotamia, one more therapeutic and one more religious; they were non-competitive and both considered reputable and essential. The therapeutic tradition is given a closer examination in order to provide a picture of how pharmaceutical ...


Best Bodybuilding Supplements : A Beginners Guide, Lissa Coffey 2013 SelectedWorks

Best Bodybuilding Supplements : A Beginners Guide, Lissa Coffey

LissaCoffey

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