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Ecthyma Gangrenosum And Panniculitis Secondary To Acute Pseudomonas Myositis Without Bacteremia, Heather Gosnell, Matthew Burke, Joseph Shnouda 2021 Lake Erie College of Osteopathic Medicine

Ecthyma Gangrenosum And Panniculitis Secondary To Acute Pseudomonas Myositis Without Bacteremia, Heather Gosnell, Matthew Burke, Joseph Shnouda

HCA Healthcare Journal of Medicine

Introduction

Ecthyma gangrenosum (EG) is a relatively uncommon cutaneous manifestation of an underlying Pseudomonas aeruginosa infection and is clinically described as necrotic with gangrenous ulcers surrounded by erythematous halos. Cases of EG may occur in the absence of bacteremia and have been increasingly reported in literature. Here we present a patient with features of both EG and panniculitis, despite the lack of underlying bacteremia.

Clinical Findings

A 57-year-old male presented to the emergency department with unrelenting right-sided lower back pain and an “itchy and painful” rash of four to five day duration. The patient had an extensive history of intravenous ...


A Research Framework For Evaluating Next Generation Sequencing In Community-Acquired Pneumonia, Ashley M. Wilde, Elena Swingler, Sarah E. Moore PharmD, Brian C. Bohn PharmD, Matthew Song PharmD, BCIDP, Ruth Carrico, Julio A. Ramirez 2021 Norton Healthcare

A Research Framework For Evaluating Next Generation Sequencing In Community-Acquired Pneumonia, Ashley M. Wilde, Elena Swingler, Sarah E. Moore Pharmd, Brian C. Bohn Pharmd, Matthew Song Pharmd, Bcidp, Ruth Carrico, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

No abstract provided.


University Of Louisville International Travel Clinic: Pivoting During The Covid-19 Pandemic, Dawn Balcom, Subathra Marimuthu, Leslie A Wolf, Luanne Didelot, Sarah Tan, Daniel Hall, Ruth Carrico 2021 University of Louisville

University Of Louisville International Travel Clinic: Pivoting During The Covid-19 Pandemic, Dawn Balcom, Subathra Marimuthu, Leslie A Wolf, Luanne Didelot, Sarah Tan, Daniel Hall, Ruth Carrico

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Impact Of Pulse Oximetry On Hospital Referral Acceptance In Children Under 5 With Severe Pneumonia In Rural Pakistan (District Jamshoro): Protocol For A Cluster Randomised Trial, Fatima Mir, Apsara Ali, Suhail Chanar, Amjad Hussain, Arjumand Rizvi, Imran Ahmed, Zahid Memon, Atif Habib, Sajid Bashir Soofi, Zulfiqar Ahmed Bhutta 2021 Aga Khan University

Impact Of Pulse Oximetry On Hospital Referral Acceptance In Children Under 5 With Severe Pneumonia In Rural Pakistan (District Jamshoro): Protocol For A Cluster Randomised Trial, Fatima Mir, Apsara Ali, Suhail Chanar, Amjad Hussain, Arjumand Rizvi, Imran Ahmed, Zahid Memon, Atif Habib, Sajid Bashir Soofi, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: Pneumonia is a leading cause of death among children under 5 specifically in South Asia and sub-Saharan Africa. Hypoxaemia is a life-threatening complication among children under 5 with pneumonia. Hypoxaemia increases risk of mortality by 4.3 times in children with pneumonia than those without hypoxaemia. Prevalence of hypoxaemia varies with geography, altitude and severity (9%-39% Asia, 3%-10% African countries). In this protocol paper, we describe research methods for assessing impact of Lady Health Workers (LHWs) identifying hypoxaemia in children with signs of pneumonia during household visits on acceptance of hospital referral in district Jamshoro, Sindh.
Methods ...


Pulmonary Inflammation And Injury Triggered By Spine Surgery In Recovered Covid-19 Patients Demand Consideration, Luciano Rodrigo Lopes, Silvana Kertzer Kasinski 2021 Universidade Federal de São Paulo (Unifesp)

Pulmonary Inflammation And Injury Triggered By Spine Surgery In Recovered Covid-19 Patients Demand Consideration, Luciano Rodrigo Lopes, Silvana Kertzer Kasinski

The University of Louisville Journal of Respiratory Infections

No abstract provided.


Assesment Of Antibiotic Resistant Gene Expression In Clinical Isolates Of Pseudomonas Aeruginosa, Dustin Esmond 2021 University of Texas at Tyler

Assesment Of Antibiotic Resistant Gene Expression In Clinical Isolates Of Pseudomonas Aeruginosa, Dustin Esmond

Biology Theses

Increasing prevalence of nosocomial infections by antimicrobial resistant pathogens resulting in higher mortality rates and financial burden is of great concern. Pseudomonas aeruginosa represents one of six highly virulent “ESKAPE” pathogens that exhibit considerable intrinsic drug resistance as well as mechanisms for acquiring further resistance. As many of these mechanisms are regulated through gene expression, we sought to identify regulatory strategies and patterns at play in 23 clinical isolates collected from Baku, Azerbaijan and Tyler, Texas, USA. Real-time quantitative polymerase chain reaction was performed on six gene targets implicated in resistance and contrasted with antibiotic phenotypes. We found AmpC cephalosporinase ...


S-Layer Increases Predation Ability Of Myxococcus Xanthus, 2021 Kennesaw State University

S-Layer Increases Predation Ability Of Myxococcus Xanthus

Symposium of Student Scholars

Background: Myxococcus xanthus is a gram-negative soil bacterium that exhibits micro-predatory activities. When starved, M. xanthus produces resistant spores within fruiting bodies for survival. The S-layer is a paracrystalline structure intertwined in many different patterns and is composed of proteins or glycoproteins. A species that produces the S-layer is Aeromonas. A. salmonicida is a strain of Aeromonas that infects fish. A. hydrophila is another pathogenic strain that causes a wide range of human diseases. We investigated the ability of the S-layer to protect Aeromonas from predation by Myxobacteria. Methods: Myxococcus and prey Aeromonas cultures were standardized to a concentration of ...


Molecular Detection Of Aspergillus Flavus In Georgia Peanut, Variety Tifguard., Carolle Zolome 2021 Kennesaw State University

Molecular Detection Of Aspergillus Flavus In Georgia Peanut, Variety Tifguard., Carolle Zolome

Symposium of Student Scholars

Peanuts provide a good source of protein, minerals, and vitamins to consumers. The US peanut industry suffers great losses of nearly $26 million annually due to contamination by Aspergillus species. In spite of strict control measures against Aspergillus species, the industry is still facing economic loss due to contamination by this mold. Poor storage of peanuts in commercial outlets can lead to infection by the mold, releasing aflatoxin which is carcinogenic. A number of DNA based techniques are currently available for identification of the fungal population. This research aims at identifying if peanut, the variety Tifguard which is highly recommended ...


Effects Of Neem Oil On Growth And Development Of Aspergillus Flavus In Peanuts, Onachukwu Nwolisa 2021 Kennesaw State University

Effects Of Neem Oil On Growth And Development Of Aspergillus Flavus In Peanuts, Onachukwu Nwolisa

Symposium of Student Scholars

Effects of Neem Oil On Growth And Development Of Aspergillus flavus in peanuts**

Ona Nwolisa and Premila N Achar1

1Dept. of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA.

Aspergillus flavus is known to contaminate peanuts and produce aflatoxin which are carcinogenic metabolites. According to the USDA, more than $1 billion is spent on infection and prevention. Currently there is no single method known to eradicate Aspergillus spp. in peanuts and the industry continue to face the aflatoxin problem. There has been an increased interest in use of plant based antifungal products which are environmentally friendly and ...


Why Should People Use Face Masks In The Time Of Covid? The Jri Position, Jose Bordon, Alex Glynn, Forest W. Arnold 2021 University of Louisville, Division of Infectious Diseases

Why Should People Use Face Masks In The Time Of Covid? The Jri Position, Jose Bordon, Alex Glynn, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

No abstract provided.


No Difference In Clinical Outcomes For African American And White Patients Hospitalized With Sars-Cov-2 Pneumonia In Louisville, Kentucky, Julio A. Ramirez, Stephen P. Furmanek, Thomas Chandler, Stephen S. Hanson, Dawn Balcom, Subathra Marimuthu, Sathya Krishnasamy, Jose Bordon, Rodrigo Cavallazzi, Amr Aboelnasr, Mahder A. Tella, William A. Mattingly, Ashley M. Wilde, Daisy Sangroula, Demetra Antimisiaris, Donghoon Chung, Guillermo Cabral, Gabino R Fernandez-Botran, Jiapeng Huang, Martin Gnoni, Ozan Akca, Paul Schulz, Phillip F. Bressoud, Priya Krishnan, Sally Suliman, William P. McKinney, Bryan Moffett, Leslie A Wolf, Mark Burns, Alex Glynn, Ruth Carrico, Forest W. Arnold 2021 University of Louisville, School of Medicine Infectious Diseases

No Difference In Clinical Outcomes For African American And White Patients Hospitalized With Sars-Cov-2 Pneumonia In Louisville, Kentucky, Julio A. Ramirez, Stephen P. Furmanek, Thomas Chandler, Stephen S. Hanson, Dawn Balcom, Subathra Marimuthu, Sathya Krishnasamy, Jose Bordon, Rodrigo Cavallazzi, Amr Aboelnasr, Mahder A. Tella, William A. Mattingly, Ashley M. Wilde, Daisy Sangroula, Demetra Antimisiaris, Donghoon Chung, Guillermo Cabral, Gabino R Fernandez-Botran, Jiapeng Huang, Martin Gnoni, Ozan Akca, Paul Schulz, Phillip F. Bressoud, Priya Krishnan, Sally Suliman, William P. Mckinney, Bryan Moffett, Leslie A Wolf, Mark Burns, Alex Glynn, Ruth Carrico, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Introduction: Current literature indicates that African American individuals are at increased risk of becoming infected with the SARS-CoV-2 virus and suffer higher SARS-CoV-2-related mortality rates. However, there is a lack of consensus as to how the clinical outcomes of African American patients differ from those of other groups. The objective of this study was to define the clinical outcomes of African American and White hospitalized patients with SARS-CoV-2 community-acquired pneumonia (CAP) in Louisville, Kentucky.

Methods: This was a retrospective cohort study of hospitalized patients with SARS-CoV-2 CAP at eight hospitals in Louisville, Kentucky. Severity of CAP at time of hospitalization ...


The Origins And Future Of Sentinel: An Early-Warning System For Pandemic Preemption And Response, Yolanda Botti-Lodovico, Andres Colubri, Pardis C. Sabeti, Christian Happi 2021 Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard

The Origins And Future Of Sentinel: An Early-Warning System For Pandemic Preemption And Response, Yolanda Botti-Lodovico, Andres Colubri, Pardis C. Sabeti, Christian Happi

COVID-19 Publications by UMass Chan Authors

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our hypothesis that natural selection acting on LARGE-detected in the Yoruba population of Nigeria-conferred resistance to Lassa Fever in some West African populations. As we delved further, we conjectured that the "emerging" nature of recently discovered diseases like Lassa fever is related to a newfound capacity for detection, rather than a novel viral presence, and that ...


From Bloom To Bust: Harmful Algae Blooms And Their Impacts On The Waterfront Economy, Sergio Alvarez 2021 University of Central Florida

From Bloom To Bust: Harmful Algae Blooms And Their Impacts On The Waterfront Economy, Sergio Alvarez

Rosen Research Review

The true costs of harmful algae blooms (HABs) and the mechanics that determine their socio-economic impacts are for the most part unknown. Florida’s 2017–2019 red tide (Karenia brevis) bloom is a historical case study of the ever-growing threats to coastal welfare posed by HABs. A new research project at Rosen College of Hospitality Management has this at its heart. The central objective of the project is the identification of direct, indirect, and induced socioeconomic impacts caused by the 2017–2019 K. brevis bloom in Florida.


Valuing The Negative Impacts Of Harmful Algae Blooms, Sergio Alvarez 2021 University of Central Florida

Valuing The Negative Impacts Of Harmful Algae Blooms, Sergio Alvarez

Rosen Research Review

Ecological disturbances can impact several ecosystem services, including cultural services such as outdoor recreation opportunities. In Florida, one ecological disturbance that is negatively impacting recreation is the occurrence of harmful algae blooms. In recent work, Dr. Sergio Alvarez at UCF Rosen College of Hospitality Management has assessed the impact that harmful algae blooms have on human wellbeing by using random utility models to estimate changes in the value of recreation in coastal ecosystems resulting from these blooms. The results indicate that harmful algae blooms, which reduced boating access between June and September 2018, may have resulted in losses of up ...


Virus-Targeted Transcriptomic Analyses Implicate Ranaviral Interaction With Host Interferon Response In Frog Virus 3-Infected Frog Tissues, Yun Tian, Francisco De Jesús Andino, Collins N. Khwatenge, Jiuyi Li, Jacques Robert, Yongming Sang 2021 Tennessee State University

Virus-Targeted Transcriptomic Analyses Implicate Ranaviral Interaction With Host Interferon Response In Frog Virus 3-Infected Frog Tissues, Yun Tian, Francisco De Jesús Andino, Collins N. Khwatenge, Jiuyi Li, Jacques Robert, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Ranaviruses (Iridoviridae), including Frog Virus 3 (FV3), are large dsDNA viruses that cause devastating infections globally in amphibians, fish, and reptiles, and contribute to catastrophic amphibian declines. FV3’s large genome (~105 kb) contains at least 98 putative open reading frames (ORFs) as annotated in its reference genome. Previous studies have classified these coding genes into temporal classes as immediate early, delayed early, and late viral transcripts based on their sequential expression during FV3 infection. To establish a high-throughput characterization of ranaviral gene expression at the genome scale, we performed a whole transcriptomic analysis (RNA-Seq) using total RNA samples containing ...


Modeling Site-Specific Nucleotide Biases Affecting Himar1 Transposon Insertion Frequencies In Tnseq Datasets [Preprint], Sanjeevani Choudhery, A. Jacob Brown, Chidiebere Akusobi, Eric J. Rubin, Christopher M. Sassetti, Thomas R. Ioerger 2021 Texas A&M University

Modeling Site-Specific Nucleotide Biases Affecting Himar1 Transposon Insertion Frequencies In Tnseq Datasets [Preprint], Sanjeevani Choudhery, A. Jacob Brown, Chidiebere Akusobi, Eric J. Rubin, Christopher M. Sassetti, Thomas R. Ioerger

University of Massachusetts Medical School Faculty Publications

In bacterial TnSeq experiments, a library of transposons insertion mutants is generated, selected under various growth conditions, and sequenced to determine the profile of insertions at different sites in the genome, from which the fitness of mutant strains can be inferred. The widely used Himar1 transposon is known to be restricted to insertions at TA dinucleotides, but otherwise, few site-specific biases have been identified. As a result, most analytical approaches assume that insertion counts are expected a priori to be randomly distributed among TA sites in non-essential regions. However, recent analyses of independent Himar1 Tn libraries in M. tuberculosis have ...


Influence Of Different Glycoproteins And Of The Virion Core On Serinc5 Antiviral Activity, William E. Diehl, Mehmet Hakan Guney, Teresa Vanzo, Pyae Phyo Kyawe, Judith M. White, Massimo Pizzato, Jeremy Luban 2021 University of Massachusetts Medical School

Influence Of Different Glycoproteins And Of The Virion Core On Serinc5 Antiviral Activity, William E. Diehl, Mehmet Hakan Guney, Teresa Vanzo, Pyae Phyo Kyawe, Judith M. White, Massimo Pizzato, Jeremy Luban

COVID-19 Publications by UMass Chan Authors

Host plasma membrane protein SERINC5 is incorporated into budding retrovirus particles where it blocks subsequent entry into susceptible target cells. Three structurally unrelated proteins encoded by diverse retroviruses, human immunodeficiency virus type 1 (HIV-1) Nef, equine infectious anemia virus (EIAV) S2, and ecotropic murine leukemia virus (MLV) GlycoGag, disrupt SERINC5 antiviral activity by redirecting SERINC5 from the site of virion assembly on the plasma membrane to an internal RAB7+ endosomal compartment. Pseudotyping retroviruses with particular glycoproteins, e.g., vesicular stomatitis virus glycoprotein (VSV G), renders the infectivity of particles resistant to inhibition by virion-associated SERINC5. To better understand viral determinants ...


Preventing Transmission Of Covid 19 In Hvac Duct Systems: Implementations Of Hvac System Design Upgrade, Jacob S. Lopez, Adama Barro 2021 CUNY New York City College of Technology

Preventing Transmission Of Covid 19 In Hvac Duct Systems: Implementations Of Hvac System Design Upgrade, Jacob S. Lopez, Adama Barro

Publications and Research

The recent pandemic outbreak has triggered a global alarm to increase efforts on finding the best methods to mitigate contagious viral pathogens. This project is a continuation of our mission to study engineering guidelines needed to implement upgrades to HVAC Systems in order to deter airborne pathogens such as the covid-19 virus. In our previous projects we researched how covid-19 can possibly flow through the ambient air inside of restaurants, office spaces, and locomotive train cabins. As we continued our research, we were able to find some solutions that will be best used to deactivate and prevent the virus from ...


A Novel In Vitro Method For Pelvic Floor Dysfunction In Pcos Women, Ruben Vila 2021 Oregon Health & Science University

A Novel In Vitro Method For Pelvic Floor Dysfunction In Pcos Women, Ruben Vila

University Honors Theses

Background:

Poly Cystic Ovary Syndrome and Pelvic Floor Dysfunction are reproductive diseases with comorbidities whose novel relationship deserves further investigation.

Methods:

Levator Ani Muscle/Paravaginal Attachment was dissected from female Rhesus Macaque and subjected to tissue dissociation. Cells were treated with serum level hormones E2, T, and DHT. PCR, ICC, and IHC were used, followed by statistical analysis.

Results:

RNA analysis show differences in relative expression for endpoints ER, PR, AR, Ki-67, Col1A, and Vimentin. IHC along with ICC showed expression and localization in vivo.

Conclusions:

A novel in vitro model was created from macaque Levator Ani Muscle/Paravaginal Attachment ...


Clarification Of Human Blood Ilc Subtype Interrelatedness And Discovery Of Amphiregulin Production By Human Nk Cells Shed Light On Hiv-1 Pathogenesis [Preprint], Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela St. Louis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, Jeremy Luban 2021 University of Massachusetts Medical School

Clarification Of Human Blood Ilc Subtype Interrelatedness And Discovery Of Amphiregulin Production By Human Nk Cells Shed Light On Hiv-1 Pathogenesis [Preprint], Yetao Wang, Lawrence M. Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela St. Louis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, Jeremy Luban

University of Massachusetts Medical School Faculty Publications

Human blood innate lymphoid cells (ILCs), which include ILCs and natural killer (NK) cells, derive from a common CD117+ILC precursor (ILCP). Yet, the relationship among the ILC subsets remains unclear. Bulk and single cell RNA-Seq and ATAC-Seq showed that blood ILC subsets cluster into ILC2s, ILCPs, a mixed cluster of CD56dim and CD56 NK cells, and a separate cluster of CD56hiNK cells that share features with both ILCs and CD56dimNK cells. In surprising contrast to mice, tissue repair protein amphiregulin was produced by human NK cells, with higher levels in CD56hiNK cells ...


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