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380 full-text articles. Page 1 of 6.

Effects Of Cannabidiol On Contractions And Calcium Signaling In Rat Ventricular Myocytes, Ramez M. Ali, Lina T. Al Kury, Keun-Hang Susan Yang, Anwar Qureshi, Mohanraj Rajesh, Sehamuddin Galadari, Yaroslav M. Shuba, Frank Christopher Howarth, Murat Oz 2015 UAE University, Al Ain, Abu Dhabi, UAE

Effects Of Cannabidiol On Contractions And Calcium Signaling In Rat Ventricular Myocytes, Ramez M. Ali, Lina T. Al Kury, Keun-Hang Susan Yang, Anwar Qureshi, Mohanraj Rajesh, Sehamuddin Galadari, Yaroslav M. Shuba, Frank Christopher Howarth, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

Cannabidiol (CBD), a major nonpsychotropic cannabinoid found in Cannabis plant, has been shown to influence cardiovascular functions under various physiological and pathological conditions. In the present study, the effects of CBD on contractility and electrophysiological properties of rat ventricular myocytes were investigated. Video edge detection was used to measure myocyte shortening. Intracellular Ca2+ was measured in cells loaded with the Ca2+ sensitive fluorescent indicator fura-2 AM. Whole-cell patch clamp was used to measure action potential and Ca2+ currents. Radioligand binding was employed to study pharmacological characteristics of CBD binding. CBD (1 μM) caused a significant decrease in the amplitudes of ...


Response Of Soil Nitrification To The Veterinary Pharmaceuticals Monensin, Ivermectin And Zinc Bacitracin, Magda A. Konopka 2014 The University of Western Ontario

Response Of Soil Nitrification To The Veterinary Pharmaceuticals Monensin, Ivermectin And Zinc Bacitracin, Magda A. Konopka

University of Western Ontario - Electronic Thesis and Dissertation Repository

Pharmaceutical residues can reach agricultural land through amendment with animal or human waste. Since 2010, a series of replicated plots received annual applications of ivermectin, monensin and zinc bacitracin, either singly or in a mixture, at 0.1 mg/kg and 10 mg/kg concentrations. I collected soil samples before and after the fourth annual application of pharmaceuticals and assayed them for functional changes and amoA gene abundance, a gene needed for ammonia oxidation. In 2013, I exposed the soils to 100 mg/kg in a laboratory experiment which resulted in acceleration of nitrification. Under 10 mg/kg treatments in ...


Dengue Virus Neutralizing Antibody Levels Associated With Protection From Infection In Thai Cluster Studies, Darunee Buddhari, Jared Aldstadt, Timothy P. Endy, Anon Srikiatkhachorn, Butsaya Thaisomboonsuk, Chonticha Klungthong, Ananda Nisalak, Benjawan Khuntirat, Richard G. Jarman, Stefan Fernandez, Stephen J. Thomas, Thomas W. Scott, Alan L. Rothman, In-Kyu Yoon 2014 Armed Forces Research Institute of Medical Sciences

Dengue Virus Neutralizing Antibody Levels Associated With Protection From Infection In Thai Cluster Studies, Darunee Buddhari, Jared Aldstadt, Timothy P. Endy, Anon Srikiatkhachorn, Butsaya Thaisomboonsuk, Chonticha Klungthong, Ananda Nisalak, Benjawan Khuntirat, Richard G. Jarman, Stefan Fernandez, Stephen J. Thomas, Thomas W. Scott, Alan L. Rothman, In-Kyu Yoon

Open Access Articles

BACKGROUND: Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection.

METHODOLOGY/PRINCIPAL FINDINGS: Data from two geographic cluster studies conducted in Kamphaeng Phet, Thailand were used for this analysis. In the first study (2004-2007), cluster investigations of 100-meter radius were triggered by DENV-infected index cases from a concurrent prospective cohort. Subjects between 6 months and 15 years old were evaluated for DENV infection at days 0 and 15 by DENV PCR and IgM ELISA. In the second study ...


Silence Is The Loudest Sound, Emma Christian 2014 University of Maine - Main

Silence Is The Loudest Sound, Emma Christian

Honors College

Rhinoceros poaching is an act of killing a rhinoceros in order to take its horn, which is then used for human consumption or for cultural traditions. Both the Asian and the African rhinoceros are targets because of the demand from China, Vietnam, Yemen, and other countries around the world. Traditional Chinese Medicine practice is the main demand for rhinoceros horn and this demand in rhinoceros horn has caused an increase in the black market. Conservation of the rhinoceros is decreasing primarily because the price of rhinoceros horn is more than double the average household income in South Africa, thus making ...


Out-Of-Sequence Signal 3 As A Mechanism For Virus-Induced Immune Suppression Of Cd8 T Cell Responses, Stina L. Urban, Raymond M. Welsh 2014 University of Massachusetts Medical School

Out-Of-Sequence Signal 3 As A Mechanism For Virus-Induced Immune Suppression Of Cd8 T Cell Responses, Stina L. Urban, Raymond M. Welsh

Open Access Articles

Virus infections are known to induce a transient state of immune suppression often associated with an inhibition of T cell proliferation in response to mitogen or cognate-antigen stimulation. Recently, virus-induced immune suppression has been linked to responses to type 1 interferon (IFN), a signal 3 cytokine that normally can augment the proliferation and differentiation of T cells exposed to antigen (signal 1) and co-stimulation (signal 2). However, pre-exposure of CD8 T cells to IFN-inducers such as viruses or poly(IratioC) prior to antigen signaling is inhibitory, indicating that the timing of IFN exposure is of essence. We show here that ...


Annotated Bibliography: Attitudes Toward Wildlife And The Environment (1998-2013), Erich Yahner 2014 Humane Society Institute for Science and Policy

Annotated Bibliography: Attitudes Toward Wildlife And The Environment (1998-2013), Erich Yahner

Humane Education Bibliographies

No abstract provided.


Annotated Bibliography: Attitudes Toward Animals (1998-2013), Erich Yahner 2014 Humane Society Institute for Science and Policy

Annotated Bibliography: Attitudes Toward Animals (1998-2013), Erich Yahner

Humane Education Bibliographies

No abstract provided.


Annotated Bibliography: Cruelty To Animals And Violence To Humans (1998-2013), Erich Yahner 2014 Humane Society Institute for Science and Policy

Annotated Bibliography: Cruelty To Animals And Violence To Humans (1998-2013), Erich Yahner

Humane Education Bibliographies

No abstract provided.


Annotated Bibliography: Humane Education (1998-2013), Erich Yahner 2014 Humane Society Institute for Science and Policy

Annotated Bibliography: Humane Education (1998-2013), Erich Yahner

Humane Education Bibliographies

No abstract provided.


Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner 2014 Humane Society Institute for Science and Policy

Annotated Bibliography: Interaction With Animals (1998-2013), Erich Yahner

Humane Education Bibliographies

No abstract provided.


The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith, Ph.D. 2014 Chapman University

The Effect Of Pomegranate Juice Extract On The Hedgehog Signaling Pathway In Pancreatic Cancer, Veronica Gomez, Talia Shackelford, Autumn Tocchi, Melissa Rowland-Goldsmith, Ph.D.

e-Research: A Journal of Undergraduate Work

Pancreatic cancer is the fourth leading cause of cancer death in the United States. There have been several reports indicating that phytochemicals in fruits can reduce the risk of cancer due to the anti-oxidant and anti-inflammatory effects of the polyphenols. Our lab has shown that pomegranate juice extract (PJE) has anti-proliferative and pro-apoptotic effects in human pancreatic cancer cells. In the past, we have shown that cells adhere more strongly to the plate when treated with PJE. This observation prompted an investigation of how PJE regulates cell adhesion proteins. Previously, our lab investigated E-cadherin, a cell adhesion protein. Upon activation ...


The Spatial Dynamics Of Dengue Virus In Kamphaeng Phet, Thailand, Piraya Bhoomiboonchoo, Robert V. Gibbons, Angkana Huang, In-Kyu Yoon, Darunee Buddhari, Ananda Nisalak, Natkamol Chansatiporn, Mathuros Thipayamongkolgul, Siripen Kalanarooj, Timothy Endy, Alan L. Rothman, Anon Srikiatkhachorn, Sharone Green, Mammen P. Mammen, Derek A. Cummings, Henrik Salje 2014 Mahidol University

The Spatial Dynamics Of Dengue Virus In Kamphaeng Phet, Thailand, Piraya Bhoomiboonchoo, Robert V. Gibbons, Angkana Huang, In-Kyu Yoon, Darunee Buddhari, Ananda Nisalak, Natkamol Chansatiporn, Mathuros Thipayamongkolgul, Siripen Kalanarooj, Timothy Endy, Alan L. Rothman, Anon Srikiatkhachorn, Sharone Green, Mammen P. Mammen, Derek A. Cummings, Henrik Salje

Open Access Articles

BACKGROUND: Dengue is endemic to the rural province of Kamphaeng Phet, Northern Thailand. A decade of prospective cohort studies has provided important insights into the dengue viruses and their generated disease. However, as elsewhere, spatial dynamics of the pathogen remain poorly understood. In particular, the spatial scale of transmission and the scale of clustering are poorly characterized. This information is critical for effective deployment of spatially targeted interventions and for understanding the mechanisms that drive the dispersal of the virus.

METHODOLOGY/PRINCIPAL FINDINGS: We geocoded the home locations of 4,768 confirmed dengue cases admitted to the main hospital in ...


Banshidhar Sahu, banshi dhar sahu mr 2014 banshidhar sahu

Banshidhar Sahu, Banshi Dhar Sahu Mr

banshi dhar sahu mr

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Banshidhar Sahu, banshi dhar sahu mr 2014 banshidhar sahu

Banshidhar Sahu, Banshi Dhar Sahu Mr

banshi dhar sahu mr

111


Banshidhar Sahu, banshi dhar sahu mr 2014 banshidhar sahu

Banshidhar Sahu, Banshi Dhar Sahu Mr

banshi dhar sahu mr

111


Banshidhar Sahu, banshi dhar sahu mr 2014 banshidhar sahu

Banshidhar Sahu, Banshi Dhar Sahu Mr

banshi dhar sahu mr

111


Banshidhar Sahu, banshi dhar sahu mr 2014 banshidhar sahu

Banshidhar Sahu, Banshi Dhar Sahu Mr

banshi dhar sahu mr

111


Profiles Of Acute Cytokine And Antibody Responses In Patients Infected With Avian Influenza A H7n9, Rui Huang, Lu Zhang, Qin Gu, Yi-Hua Zhou, Yingying Hao, Kui Zhang, Yong Liu, Danjiang Dong, Shixia Wang, Zuhu Huang, Shan Lu, Chao Wu 2014 Nanjing University Medical School

Profiles Of Acute Cytokine And Antibody Responses In Patients Infected With Avian Influenza A H7n9, Rui Huang, Lu Zhang, Qin Gu, Yi-Hua Zhou, Yingying Hao, Kui Zhang, Yong Liu, Danjiang Dong, Shixia Wang, Zuhu Huang, Shan Lu, Chao Wu

Open Access Articles

The influenza A H7N9 virus outbreak in Eastern China in the spring of 2013 represented a novel, emerging avian influenza transmission to humans. While clinical and microbiological features of H7N9 infection have been reported in the literature, the current study investigated acute cytokine and antibody responses in acute H7N9 infection. Between March 27, 2013 and April 23, 2013, six patients with confirmed H7N9 influenza infection were admitted to Drum Tower Hospital, Nanjing, China. Acute phase serum cytokine profiles were determined using a high-throughput multiplex assay. Daily H7 hemagglutinin (HA)-specific IgG, IgM, and IgA responses were monitored by ELISA. Neutralizing ...


Banshidhar Sahu, banshi dhar sahu mr 2014 banshidhar sahu

Banshidhar Sahu, Banshi Dhar Sahu Mr

banshi dhar sahu mr

111


Aquastella Gen. Nov.: A New Genus Of Saprolegniaceous Oomycete Rotifer Parasites Related To Aphanomyces, With Unique Sporangial Outgrowths, Daniel P. Molloy, Sally L. Glockling, Clifford A. Siegfried, Gordon W. Beakes, Timothy Y. James, Sergey E. Mastitsky, Elizabeth S. Wurdak, Laure Giamberini, Michael J. Gaylo, Michael J. Nemeth 2014 College of Saint Benedict/Saint John's University

Aquastella Gen. Nov.: A New Genus Of Saprolegniaceous Oomycete Rotifer Parasites Related To Aphanomyces, With Unique Sporangial Outgrowths, Daniel P. Molloy, Sally L. Glockling, Clifford A. Siegfried, Gordon W. Beakes, Timothy Y. James, Sergey E. Mastitsky, Elizabeth S. Wurdak, Laure Giamberini, Michael J. Gaylo, Michael J. Nemeth

Biology Faculty Publications

The oomycete genus Aquastella is described to accommodate two new species of parasites of rotifers observed in Brooktrout Lake, New York State, USA. Three rotifer species – Keratella taurocephala,Polyarthra vulgaris, and Ploesoma truncatum – were infected, and this is the first report of oomycete infection in these species. Aquastella attenuata was specific to K. taurocephala and Aquastella aciculariswas specific to P. vulgaris and P. truncatum. The occurrence of infections correlated with peak host population densities and rotifers were infected in the upper layers of the water column. Sequencing of 18S rRNA and phylogenetic analysis of both species placed them within ...


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