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Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin VanMouwerik, Merhawi Yigzaw, Reza Alavi 2014 Georgia State University

Mamba Juice: Expression Of Exogenous Mambalgin Peptide Using The Pgapzα Vector System, Lydia Studdard, Kristin Vanmouwerik, Merhawi Yigzaw, Reza Alavi

Georgia State Undergraduate Research Conference

No abstract provided.


Taxis Toward Hydrogen Gas By Methanococcus Maripaludis, Kristen A. Brileya, James M. Connolly, Carey Downey, Robin Gerlach, Matthew W. Fields 2013 Portland State University

Taxis Toward Hydrogen Gas By Methanococcus Maripaludis, Kristen A. Brileya, James M. Connolly, Carey Downey, Robin Gerlach, Matthew W. Fields

Biology Faculty Publications and Presentations

Knowledge of taxis (directed swimming) in the Archaea is currently expanding through identification of novel receptors, effectors, and proteins involved in signal transduction to the flagellar motor. Although the ability for biological cells to sense and swim toward hydrogen gas has been hypothesized for many years, this capacity has yet to be observed and demonstrated. Here we show that the average swimming velocity increases in the direction of a source of hydrogen gas for the methanogen, Methanococcus maripaludis using a capillary assay with anoxic gas-phase control and time-lapse microscopy. The results indicate that a methanogen couples motility to hydrogen concentration ...


A Box Of Paradoxes: The Fascinating World Of Viruses, Boriana Marintcheva 2013 Bridgewater State University

A Box Of Paradoxes: The Fascinating World Of Viruses, Boriana Marintcheva

Bridgewater Review

No abstract provided.


Development Of A Novel Luciferase Reporter Tool For High Throughput Gene Expression Analysis In Streptomyces, Margot Smith 2013 McMaster University

Development Of A Novel Luciferase Reporter Tool For High Throughput Gene Expression Analysis In Streptomyces, Margot Smith

Open Access Dissertations and Theses

Streptomycetes biology and genetics encompasses a variety of interesting features including multicellular growth, rich secondary metabolite production, and extensive environmental sensory and response systems. The characteristically large genomes of streptomycetes makes studying the diverse external stimuli intricate and internal regulation of these gene systems a challenge. Currently, there does not exist an efficient, cost-effective method of high throughput gene expression analysis in streptomycetes. Luciferase reporters have been used successfully in Streptomyces coelicolor to measure select promoter activity, however, they have demonstrated limited success in other strains and are not favourable to gene expression studies on a larger scale. Here, I ...


Welcome To The Journal Of Evolution And Health, Aaron Blaisdell, Paul Jaminet, David C. Pendergrass 2013 Ancestral Health Society

Welcome To The Journal Of Evolution And Health, Aaron Blaisdell, Paul Jaminet, David C. Pendergrass

Journal of Evolution and Health

Welcome to the first issue of the Journal of Evolution and Health! The Journal of Evolution and Health is the peer-reviewed, open-access journal of the Ancestral Health Society, a community of scientists, healthcare professionals, and laypersons who collaborate to understand health challenges from an evolutionary perspective.


Novel Inducers Of Gliotoxin Production In Aspergillus Fumigatus, Taylor J. Schoberle 2013 Texas Medical Center Library

Novel Inducers Of Gliotoxin Production In Aspergillus Fumigatus, Taylor J. Schoberle

UT GSBS Dissertations and Theses (Open Access)

Secondary metabolites are produced by numerous organisms and can either be benign to humans or harmful. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often located in subtelomeric regions of the chromosome. These clusters are often coordinately regulated, being almost exclusively dependent on transcription factors that are located within the clusters themselves. Secondary metabolites are also regulated by a variety of factors, including nutritional factors, environmental factors and developmental processes. Gliotoxin, which is produced by a variety of Aspergillus species, Trichoderma species, and Penicillium species, exhibits immunosuppressive properties and ...


The Epidemiology Of Human Herpesvirus-8: Transmission Of Infection To Children In Zambian Households, Kay L. Crabtree 2013 University of Nebraska - Lincoln

The Epidemiology Of Human Herpesvirus-8: Transmission Of Infection To Children In Zambian Households, Kay L. Crabtree

Dissertations and Theses in Biological Sciences

Human Herpes virus-8 (HHV-8) is the known etiologic agent for several malignant pathologies, including Kaposi’s sarcoma (KS), the most common tumor in children in sub-Saharan Africa. Saliva is implicated as the culprit of transmission; however there is a paucity of information regarding transmission to young children. In this study, we investigated the hypothesis that household behaviors exposing the susceptible child to saliva increase the risk of transmission of HHV-8 to that child.

To test our hypothesis a large prospective cohort study in Lusaka, Zambia, enrolling 464 young children and their households, was followed for 48 months. Socio-demographics, health histories ...


Human Adenovirus E1a Binds And Retasks Cellular Hbre1, Blocking Interferon Signalling And Activating Virus Early Gene Transcription, Gregory J. Fonseca 2013 Western University

Human Adenovirus E1a Binds And Retasks Cellular Hbre1, Blocking Interferon Signalling And Activating Virus Early Gene Transcription, Gregory J. Fonseca

University of Western Ontario - Electronic Thesis and Dissertation Repository

Upon infection, human adenovirus (HAdV) must block interferon signaling and activate the expression of its early genes to reprogram the cellular environment to support virus replication. During the initial phase of infection, these processes are orchestrated by the first HAdV gene expressed during infection, early region 1A (E1A). E1A binds and appropriates components of the cellular transcriptional machinery to modulate cellular gene transcription and activate viral early genes transcription. We have identified hBre1/RNF20 as a novel target of E1A. hBre1 is an E3 ubiquitin ligase which acts with the Ube2b E2 conjugase and accessory factors RNF40 and WAC1 to ...


A Literature Review Of The Health Effects Of A Plant Based Diet Versus An Animal Based Diet, James Cote 2013 Liberty University

A Literature Review Of The Health Effects Of A Plant Based Diet Versus An Animal Based Diet, James Cote

Senior Honors Papers

Health and nutrition can mean a myriad of things to many people in today’s culture. The majority of the time people are unaware of the proper nutrients their body needs and how to get them from food. This thesis will seek to expose the health benefits that are associated with consuming a raw plant-based die, offering a more profound and encompassing view on nutrition. Investigating further into today’s most common diseases such as diabetes, heart disease, obesity, cancer and autoimmune disorders, it will seek to discover and answer why we have so many health issues. This thesis will ...


Human-Animal Interaction (Hai) In Research And Clinical Practice, Deborah Linder, Megan Mueller 2013 University of Massachusetts Medical School

Human-Animal Interaction (Hai) In Research And Clinical Practice, Deborah Linder, Megan Mueller

UMass Center for Clinical and Translational Science Research Retreat

Human-animal interaction is any interaction between humans and animals: educational outreach or activities that discuss the topic of animals or pets; pets in households; animal visitation from registered therapy animals; animal assisted therapy (AAT) and animal assisted activities (AAA). As part of a mini-symposium highlighting collaborative research opportunities with the Tufts Cummings School of Veterinary Medicine, this presentation discusses the benefits of human-animal interaction and the need for more rigorous evidence-based conclusions in this field.


Maternal Obesity Alters Fetal Development Due To Impaired Placental Function And Has Lasting Effects On Adult Offspring, Kristin Ann Norwood 2013 University of Nebraska - Lincoln

Maternal Obesity Alters Fetal Development Due To Impaired Placental Function And Has Lasting Effects On Adult Offspring, Kristin Ann Norwood

Theses and Dissertations in Animal Science

Obesity is an epidemic in many developed nations and maternal obesity can result in developmental alterations in offspring that have long-lasting effects. Two experiments were conducted to determine the impact of maternal obesity on placental development and early embryonic growth and muscle development. Experiment one utilized obese Lethal Yellow (LY) and normal weight C57BL/6 (B6) dams to assess how maternal obesity alters skeletal muscle development in mid-gestational embryos. Embryos from LY dams exhibited decreased embryo and placental weights as well as an increase in the myogenic marker desmin. Furthermore, the adipogenic marker PPARG expression was predominately localized to the ...


Antimicrobial Activity Of Various Antibiotics Against Klebsiella Pneumoniae Carbapenemase (Kpc)-Producing Bacteria, Basem H. Sadaka, Paola C. Zucchi, Todd M. Lasco 2013 Northeastern University

Antimicrobial Activity Of Various Antibiotics Against Klebsiella Pneumoniae Carbapenemase (Kpc)-Producing Bacteria, Basem H. Sadaka, Paola C. Zucchi, Todd M. Lasco

Honors Junior/Senior Projects

No abstract provided.


Effects Of Clostridium Difficile On The Human Immune Response, Mike McGovern 2013 Bryant University

Effects Of Clostridium Difficile On The Human Immune Response, Mike Mcgovern

Honors Projects in Science and Technology

Clostridium difficile is a bacterium that is rapidly becoming a large issue in the medical community due to its tendency to infect hospital patients and its resistance to antibiotics. By studying the way in which the pathogen interacts with the human immune system, it is possible to better understand how the body naturally fights off the disease. This knowledge can allow medical professionals to develop treatments that can help curtail the infection before serious symptoms occur. Working under a grant program alongside Professors Kirsten Hokeness and Chris Reid, I was able to research the effects that exposure to the C ...


An In-Depth Look At Recent Influenza Seasons And Vaccine Effectiveness, Ariana Ricci 2013 Bryant University

An In-Depth Look At Recent Influenza Seasons And Vaccine Effectiveness, Ariana Ricci

Honors Projects in Science and Technology

This paper aims to present an in-depth exploration of immunology, the influenza virus, vaccination, and vaccination’s effectiveness with respect to influenza. It also delves into the possible causes behind the large increase in early childhood deaths during the 2003-2004 influenza season, which was a turning point in terms of influenza incident reporting. Finally, data analysis on the relationship between childhood flu vaccine coverage and childhood outpatient ILI (influenza-like illness) visits by region is presented as a measurement of vaccine effectiveness and identifier of trends. Although this relationship was not statistically significant (alpha=0.05) regionally, this simply points to ...


Is The Use Of Intestinal Helminths Safe And Effective In The Treatment Of Allergic Rhinitis?, Tanner McCalley 2013 Philadelphia College of Osteopathic Medicine

Is The Use Of Intestinal Helminths Safe And Effective In The Treatment Of Allergic Rhinitis?, Tanner Mccalley

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this EBM review is to determine whether the use of intestinal helminths is safe and effective in the treatment of allergic rhinitis.

STUDY DESIGN: Review of three English language, blinded randomized controlled trials from 2009, 2010, and 2010.

DATA SOURCE: Randomized, controlled, blinded trials comparing the use of intestinal helminths versus visually matched placebo as a treatment for allergic rhinitis found using PubMed and Ovid databases.

OUTCOMES MEASURED: Several different systems were used to evaluate the symptoms or occurrence of AR. Bager et al.2010 uses symptom scores of AR scale of 0 to 3. Feary ...


Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne 2013 University of Kentucky

Effects Of Intranasally Administered Dnsp-11 On The Central Dopamine System Of Normal And Parkinsonian Fischer 344 Rats, James H. Sonne

Theses and Dissertations--Anatomy and Neurobiology

Due to the blood-brain barrier, delivery of many drugs to the brain has required intracranial surgery which is prone to complication. Here we show that Dopamine Neuron Stimulating Peptide 11 (DNSP-11), following non-invasive intranasal administration, protects dopaminergic neurons from a lesion model of Parkinson’s disease in the rat. A significant and dose-dependent increase in an index of dopamine turnover (the ratio of DOPAC to dopamine) was observed in the striatum of normal young adult Fischer 344 rats by whole-tissue neurochemistry compared to vehicle administered controls.

Among animals challenged with a moderate, unilateral 6-hydroxy-dopamine (6-OHDA) lesion of the substantia nigra ...


The Effect Of Visual Wulst Lesions And Trigeminal Nerve Sectioning On The Discrimination Of Magnetic Inclination In The Homing Pigeon (Columba Livia), Merissa Acerbi 2013 Bowling Green State University

The Effect Of Visual Wulst Lesions And Trigeminal Nerve Sectioning On The Discrimination Of Magnetic Inclination In The Homing Pigeon (Columba Livia), Merissa Acerbi

Honors Projects

The ability of homing pigeons to return to their loft from unknown places has fascinated scientists for centuries. It is well established that homing pigeons, like migratory birds, posses an innate magnetic inclination compass to determine direction by measuring the angle between the magnetic field vector and the Earth's surface. Recent work has indicated that the avian magnetic compass is light mediated and appears to mediate magnetic information to the brain. This occurs via a visual pathway with processing in the visual Wulst area of the forebrain. There is, however, also evidence from other avian species that magnetic direction ...


Reviewing The American University Law Review On Extraterritoriality: A Critical Response To Viki Economides, Note, Tianrui Group Co. V. Itc: The Dubious Status Of Extraterritoriality And The Domestic Industry Requirement Requirement Of Section 337(Link), Jonathan R. K. Stroud 2012 SelectedWorks

Reviewing The American University Law Review On Extraterritoriality: A Critical Response To Viki Economides, Note, Tianrui Group Co. V. Itc: The Dubious Status Of Extraterritoriality And The Domestic Industry Requirement Requirement Of Section 337(Link), Jonathan R. K. Stroud

Jonathan R. K. Stroud

Recently, the Federal Circuit upheld the Commission’s decision to exclude goods based on a trade secret violation that largely happened abroad. The American University Law Review critiqued that decision on two grounds: First, that a presumption against extraterritorial application of U.S. law applied; and second, that licensing alone could not establish a domestic industry. The American University Law Review's critique remains incomplete, however, as the Federal Circuit correctly decided the case for at least two reasons. first, the Federal Circuit correctly applied the “extraterritorial presumption” canon of construction; and second, the recent Federal Circuit decision in InterDigital ...


Characterization Of Antiviral Properties Of Trappin-2 And Elafin Against Hiv-1 And Hsv-2 In The Female Genital Mucosa, Anna Drannik 2012 McMaster University

Characterization Of Antiviral Properties Of Trappin-2 And Elafin Against Hiv-1 And Hsv-2 In The Female Genital Mucosa, Anna Drannik

Open Access Dissertations and Theses

Sexually transmitted infections (STIs), especially HIV/AIDS and HSV-2, continue to be a devastating burden on societies around the world. The close link between HSV-2 and HIV-1, the role of inflammation in driving these infections, and the limited success and availability of prophylactic and therapeutic measures underscore the need for continued search of alternative means of protection. Characterization of endogenous antimicrobials, especially those local to the female genital tract and actively regulating inflammatory and antiviral responses, could be beneficial for microbicidal trials. Although regulators of mucosal immunity, such as serine antiproteases, trappin-2 and elafin (Tr/E), have been associated with ...


Bugs In The News: Arbovirus And Hantavirus, Richard N. Bradley 2012 SelectedWorks

Bugs In The News: Arbovirus And Hantavirus, Richard N. Bradley

Richard N Bradley

The objectives of this presentation are:

(1) Recognize zoonotic infections of public health importance that are currently in the news

(2) Understand the clinical presentations of arbovirus and hantavirus

(3) Describe actions a physician should take when suspecting one of these infections


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