Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons^™

Differential Diagnosis Of Exercise-Induced Laryngeal Obstruction And Exercise-Induced Asthma, Allison Lyman, Allison Lyman

Honors College Theses

Sensations of shortness of breath and difficulty breathing are not uncommon, especially among athletes and those who regularly engage in aerobic activities. Often, athletes will seek treatment for their respiratory symptoms and may be diagnosed with exercise-induced asthma. Doctors prescribe inhalers to these individuals to help alleviate their symptoms; however, there are occasions in which inhalers fail to lessen the severity of breathing difficulties. This is because asthma is not the only condition that can cause shortness of breath, also known as dyspnea. There exists another condition which affects the vocal folds but not the lungs and bronchioles as is ...

Using Collaborative Objective Simulation Clinical Evaluation With Undergraduate Nursing Students And Nurse Anesthesia Students Labor Epidural Placement In An Active Labor Patient, Chaka K. Jackson, Aisha Pierre

Doctoral Projects

Developing interdisciplinary teamwork and patient communication skills are essential for the student registered nurse anesthetist (SRNA) to provide quality patient care when administering epidural anesthesia. The synthesis of the evidence revealed limited available information on simulation use for SRNA epidural administration and collaboration. This doctoral project examined the effectiveness of learning through traditional simulation to enhance communication and collaboration between the Bachelor of Science in Nursing (BSN) and the Nurse Anesthesia Program (NAP) students. The BSN and NAP students were provided with a simulation environment to care for a laboring patient while improving patient safety and quality outcomes. The project ...

An Analysis Of A New Shoe Technology In The Gait Patterns Of A Child With A Neurological Disability, Emma Madonna, Jeff Bauer

The SUNY Journal of the Scholarship of Engagement: JoSE

This study focused on the application of a unique technology originally designed to supply biofeedback to dancers, but in this case was used to assist a child learning to walk while battling the effects of Cerebral Palsy. The musical shoes, called Electroskip^TM, utilize a biofeedback system that generates variable sounds/beats/songs when an individual is walking and placing pressure on their heel or toe. The study lasted six weeks with two sessions per week. Each session started with shoes fitted with Electroskip^TM technology placed on the child’s feet. When instructed by the researcher the child would ...

Fall Detection: Threshold Analysis Of Wrist-Worn Motion Sensor Signals, Michael J. Wolfe, Jospeh Caguioa, Andy Nguyen, Jacquelyn Cheun Phd

SMU Data Science Review

In this paper, we present a detection algorithm that accurately differentiates the event of a person falling from normal Activities of Daily Living (ADL). Our algorithm processes signals recorded from accelerometers and gyroscopes built into wearable activity monitoring devices such as smart watches that are worn on an individual’s wrist. Existing algorithms are accurate but imprecise, and rely too much on inconveniently-placed sensors. We propose a pipeline that improves precision without sacrificing accuracy and ease of use. We present the use of a combination of threshold-based and machine learning-based approaches to develop a refined fall-detection algorithm that builds upon ...

Enhanced Extraction Technique Of Omarigliptin From Human Plasma-Applied To Biological Samples From Healthy Human Volunteers, Shereen Mowaka, Nermeen Ashoush, Mariam M. Tadros, Noha M. Elzahar, Bassam Ayoub

Pharmacy

Enhancing drug extraction from human plasma is a challenging approach that critically affects pharmacokinetic and any further clinical studies based on the drug Cmin and Cmax values. It also has a serious impact on the sensitivity and the lower limit of quantification (LLOQ) value of the bio-analytical methods. An advanced liquid chromatography tandem mass spectrometry (LC-MS/MS) bio-analytical method of omarigliptin (25–1000 nM) was established in human plasma using one-step liquid-liquid extraction. Alogliptin was used as an internal standard (IS) to attain good recovery and reproducibility while reducing the effects of the matrix. Enhanced plasma extraction of omarigliptin was ...

Optimizing Preprocessing Of Fmri Data To Maximize Correspondence Of Functional Anatomy Across Individuals, Nargess Ghazaleh

Electronic Thesis and Dissertation Repository

In movie-activation fMRI, intersubject correlation (ISC) indicates a functional correspondence across viewers. Brains differ in shape; spatial normalization and smoothing enhance inter-subject functional overlap. We compare 3 normalization methods (SPM12, DARTEL and ANTS) and 6 smoothing levels to discover which method yields the best functional overlap, indexed by ISC. This is key to optimizing data analysis in clinical studies using movie-activation fMRI in future. In a 3T scanner, 44 healthy subjects watched an 8-min movie. Both normalization and smoothing affected the strength and extent of the ISC. ISC values were more robust for ANTs and DARTEL than for SPM12 and ...

Estimating Partial Body Ionizing Radiation Exposure By Automated Cytogenetic Biodosimetry, Peter Rogan

Biochemistry Publications

Purpose: Inhomogeneous exposures to ionizing radiation can be detected and quantified with the Dicentric Chromosome Assay (DCA) of metaphase cells. Complete automation of interpretation of the DCA for whole body irradiation has significantly improved throughput without compromising accuracy, however low levels of residual false positive dicentric chromosomes (DCs) have confounded its application for partial body exposure determination.

Materials and Methods: We describe a method of estimating and correcting for false positive DCs in digitally processed images of metaphase cells. Nearly all DCs detected in unirradiated calibration samples are introduced by digital image processing. DC frequencies of irradiated calibration samples and ...

Factors Affecting The Characterization Of Post-Exertional Malaise Derived From Patient Input, Carly S. Holtzman, Claire Fisher, Shaun Bhatia, Leonard A. Jason

Journal of Health Disparities Research and Practice

The National Institutes of Health/Center for Disease Control and Prevention (NIH/CDC) Common Data Elements (CDE) established a post-exertional malaise (PEM) workgroup with the task of describing PEM and recommending a standardized way of assessing it in patients with myalgic encephalomyelitis and chronic fatigue syndrome (ME/CFS). As a stigmatized group, patients with ME/CFS are in need of instruments which can properly describe their symptomatic experiences, which can help reduce the disparity between illness seriousness and appropriate attention from healthcare. The current study explored attitudes and preferences among 115 patients with ME/CFS who participated in the creation ...

Predicting Postoperative Delirium Risk For Intracranial Surgery: A Statistical Machine Learning Approach, Juliet Aygun, Alaina Bartfeld, Sahana Rayan

The Journal of Purdue Undergraduate Research

No abstract provided.

Tratamientos Tópicos Oculares Para El Segmento Anterior Y Uso De Fármacos Diagnósticos En Población Pediátrica, Adriana Camila Gayón Muñoz, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

En los niños, la prescripción de medicamentos para el diagnóstico y tratamiento de patologías de segmento anterior representa un gran reto para los profesionales de la salud, debido a que se requiere de un amplio conocimiento sobre el momento de prescribirlos y de ofrecer tratamientos efectivos, con mínimo riesgo de generar efectos adversos. Este trabajo tuvo como propósito referenciar aspectos que se deben tener en cuenta en la formulación de medicamentos tópicos oculares, para el diagnóstico y tratamiento de patologías oculares de segmento anterior, en niños menores de 12 años. Para esto, se adelantó una búsqueda y revisión documental, en ...

Efecto De Los Prismas Gemelos En La Atención, Postura Y Comportamiento En Niños Con Trastorno Del Espectro Autista (Tea), Elizabeth Casillas Casillas, Jaime Bernal Escalante, Sergio Ramírez González, Luis Héctor Salas Hernández, Raúl Arias Ulloa, José De Jesús Espinosa Galaviz, Luis Fernando Barba-Gallardo

Ciencia y Tecnología para la Salud Visual y Ocular

El trastorno del espectro autista (TEA) se caracteriza por una alteración generalizada del desarrollo cerebral, que afecta la socialización, comunicación, imaginación y reciprocidad emocional y se evidencia mediante conductas repetitivas e inusuales. El uso de prismas gemelos estimula una reorganización neurológica y provoca cambios en la percepción visual. El objetivo del presente artículo fue evaluar las habilidades visuales y determinar el efecto de los prismas gemelos en la atención, postura y comportamiento de los niños con TEA. Se elaboró un estudio de intervención con muestras pareadas antes-después; se incluyeron 20 niños con diagnóstico de TEA en edades de 4 a ...

Chromatic Perception Mediates The Response To Red, Green, Blue, And Yellow Stimuli Among Children From Elementary School In Mexico, Myrna Miriam Valera Mota, Jorge Bernal Hernández, Ilhuicamina Melina Ávila Lara, Enrique Jiménez Valencia, Mariana Guzmán Noriega

Ciencia y Tecnología para la Salud Visual y Ocular

Purpose: We evaluated the responses to chromatic perception (wavelength) stimuli in the visible spectrum among children from an elementary school in Nezahualcoyotl Country, Mexico.Materials and Methods: A software developed ad hoc was used to measure how children perceived the colors blue, green, yellow, and red. The tests were in monocular form, and responses were pooled based on their similarity according to the Pearson correlation index and cluster analysis by unweighted averages. A chi-square test was applied to the groups for significant differences. Results: Data from each wavelength were analyzed in relation to age, sex, and ocular laterality. At a ...

Etiología Y Factores Asociados A Fototoxicidad Retinal, Angélica María Cristancho Chaparro, Diana V. Rey-Rodríguez

Ciencia y Tecnología para la Salud Visual y Ocular

Los efectos nocivos de la radiación solar en la piel y en la superficie ocular se conocen claramente; sin embargo, los daños fotoquímicos en la retina aún son motivo de investigación. Se ha documentado que incluso el tiempo reducido, único o recurrente de exposición a la radicación puede inducir cambios histológicos que afectan la calidad de la visión, desde alteraciones transitorias hasta maculopatías irreversibles. Pese a esto, existe limitada información sobre la prevalencia e incidencia de los casos relacionados a exposición lumínica ambiental u ocupacional. Esta investigación tuvo propósito identificar la etiología y factores asociados a fototoxicidad retinal adquirida y ...

Manifestaciones Oculares Del Covid-19, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.

Understanding Covid-19: From Origin To Potential Therapeutics, Muhammad Moazzam, Muhammad Imran Sajid, Hamza Shahid, Jahanzaib Butt, Irfan Bashir, Muhammad Jamshaid, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari

Pharmacy Faculty Articles and Research

Currently, a global pandemic era of public health concerns is going on with the Coronavirus Disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The first case of COVID-19 was reported from Wuhan’s Huanan seafood market in China late December 2019. Bats, pangolins, and snakes have been nominated as salient carriers of the virus. Thanks to its high pathogenicity, it can cause severe respiratory infections. Fever, dry cough, sore throat, pneumonia, septic shock, and ground-glass opacities are the foremost clinical manifestations of COVID-19. Immunocompromised patients are at high risk for COVID-19 infection and may lead ...

Detection Of Left Ventricular Thrombi On Cardiac Magnetic Resonance Viability Studies, Donya Ahmed Alhassan, Khawaja Bilal Waheed, Muhammad Nasim Sharif, Muhammad Zia Ulhassan, Fazal Ghaffar, Khaled Saleh Saleem, Emad Fouad Mahmoud Said, Bayan Mohammed Altalaq, Zechariah Jebakumar Arulanantham, Ahmad Omar Qarmash

Journal of the Saudi Heart Association

Objective: To highlight detection of left ventricular thrombi on cardiac magnetic resonance (CMR) viability studies.

Method: This retrospective observational study was conducted in the Radiology Department at our Hospital in Dhahran, from April 2015-2019. All recently re-perfused (post-percutaneous coronary intervention/ PCI) patients with ST-segment elevation myocardial infarctions (STEMI), having low ejection fractions (

Results: Of the 125 patients, most were men (71.2%) with a mean age of 56.78 years. Eleven patients had left ventricular thrombi (8.8%), and most of these were anterior wall infarctions with low ejection fractions (

Conclusion: Left ventricular thrombi can be detected on cardiac viability ...

Effect Of Cannabidiol And ∆9-Tetrahydrocannabinol Concentration On Breast Cancer Cell Viability, Dorothy Achiaa Agyemang

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

-Tetrahydrocannabinol (THC) and cannabidiol (CBD) are phytocannabinoids that have a potential impact in cancer treatments. Studies have shown that certain cannabinoids cause cancer cells to die, but only with selective concentrations, which have not been well documented. The first study of this thesis was to determine the exact concentration of CBD and THC needed to kill human MCF-7 breast cancer cells rather than create mass multiplication leading to more growth of the cancer. To conduct this experiment, cell culture was performed with a MCF-7 breast cancer cell line. The treatment groups were treated with CBD or THC at varying concentrations ...

Searching For Covid-19 Treatments: First, Do No Harm, Roy Guharoy, Edward Krenzelok

COVID-19 Publications by UMMS Authors

FDA is the gatekeeper to protect the public health and is critical to sustain US global leadership in drug innovation. Our foundation of evidence-based clinical practice is based on large, well-designed randomized controlled trials. The failure of HCQ against COVID-19 stands as prime example of the urgent need for adherence to science. Rigorous scientific objectivity Downloaded from https://academic.oup.com/ajhp/advance-article/doi/10.1093/ajhp/zxaa257/5879960 by Medical Center Library user on 17 August 2020 13 and independence must prevail in any future EUA decision by FDA. Trust in FDA’s mission to approve safe and effective ...

Melting Dsdna Donor Molecules Potentiates Precision Genome Editing In C. Elegans, Krishna S. Ghanta, Craig C. Mello

University of Massachusetts Medical School Faculty Publications

CRISPR genome editing has revolutionized genetics in many organisms. In the nematode Caenorhabditis elegans one injection into each of the two gonad arms of an adult hermaphrodite exposes hundreds of meiotic germ cells to editing mixtures, permitting the recovery of multiple indels or small precision edits from each successfully injected animal. Unfortunately, particularly for long insertions, editing efficiencies can vary widely, necessitating multiple injections, and often requiring co-selection strategies. Here we show that melting double stranded DNA (dsDNA) donor molecules prior to injection increases the frequency of precise homology-directed repair (HDR) by several fold for longer edits. We describe troubleshooting ...

Review Of Kelly Pender's Being At Genetic Risk: Toward A Rhetoric Of Care, Jillian K. Zwilling

Rhetoric of Health & Medicine

Being at Genetic Risk: Toward a Rhetoric of Care. Kelly Pender. University Park, PA, The Pennsylvania State Press, 2018. 174 pages, $69.95 hardcover. Publisher webpage: https://www.psupress.org/books/titles/978-0-271-08212-7.html

DOI: 10.5744/rhm.2020.1019