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Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons

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The Effect Of Therapeutic Horseback Riding On Balance And Self-Efficacy In Children With Developmental Disabilities, Lauren M. Hurley, Alexandra Smola 2016 University of Akron Main Campus

The Effect Of Therapeutic Horseback Riding On Balance And Self-Efficacy In Children With Developmental Disabilities, Lauren M. Hurley, Alexandra Smola

Honors Research Projects

The prevalence of developmental disabilities in children in the United States is a serious problem. Since children with developmental disabilities often show decreased self-efficacy and balance, researchers have studied the effects of interventions in this population. The purpose of this study is to determine the effect of a 10-week THR session on balance and task-specific self-efficacy in children with physical disabilities ages 6 to 18 years old. Bandura’s social cognitive theory and The Physical Stress Theory will guide the quasi-experimental study. A pre-test post-test design will be implemented over a 12 week span at 3 different riding centers in ...


Chemical Biology Of Protein Arginine Modifications In Epigenetic Regulation, Jakob Fuhrmann, Kathleen W. Clancy, Paul R. Thompson 2015 The Scripps Research Institute

Chemical Biology Of Protein Arginine Modifications In Epigenetic Regulation, Jakob Fuhrmann, Kathleen W. Clancy, Paul R. Thompson

Thompson Lab Publications

Review article on histone citrullination (arginine deimination), histone arginine methylation, and noncanonical histone arginine modifications.


A Systematic Review Of Studies Comparing Diagnostic Clinical Prediction Rules With Clinical Judgement, Sharon Sanders, Jenny A. Doust, P. Glasziou 2015 Bond University

A Systematic Review Of Studies Comparing Diagnostic Clinical Prediction Rules With Clinical Judgement, Sharon Sanders, Jenny A. Doust, P. Glasziou

Faculty of Health Sciences & Medicine Publications

Diagnostic clinical prediction rules (CPRs) are developed to improve diagnosis or decrease diagnostic testing. Whether, and in what situations diagnostic CPRs improve upon clinical judgment is unclear.

We searched MEDLINE, Embase and CINAHL, with supplementary citation and reference checking for studies comparing CPRs and clinical judgment against a current objective reference standard. We report 1) the proportion of study participants classified as not having disease who hence may avoid further testing and or treatment and 2) the proportion, among those classified as not having disease, who do (missed diagnoses) by both approaches. 31 studies of 13 medical conditions were included ...


Functional Analysis Of The Molluscum Contagiosum Virus Mc160 Death Effector Domain-Containing Protein Rxdl Motif, Sarah Weber 2015 Seton Hall University

Functional Analysis Of The Molluscum Contagiosum Virus Mc160 Death Effector Domain-Containing Protein Rxdl Motif, Sarah Weber

Seton Hall University Dissertations and Theses (ETDs)

The Molluscum contagiosum virus (MCV) is a member of the Poxviridae family that causes benign skin lesions. MCV lesions persist on average for 8-12 months in otherwise healthy individuals. MCV lesions are characterized by reduced inflammation. The persistence and reduction of inflammation at the site of MCV lesions have been attributed to MCV immune evasion genes. MCV encodes two death effector domain (DED) containing proteins, MC159 and MC160. DEDs are found in cellular proteins such as FADD and procaspase-8. These cellular proteins are involved in several innate immune responses such as apoptosis and activation of interferon (IFN). Presumably, MC159 and ...


A Study To Evaluate The Maximal Dose Administration At Two Different Locations In Two Different Vdr4 High Frequency Percussive Ventilator (Hpfv) Circuits, Jeff L. Heltborg, Bethany S. Kobza, Ace Nilson 2015 Legacy Health System

A Study To Evaluate The Maximal Dose Administration At Two Different Locations In Two Different Vdr4 High Frequency Percussive Ventilator (Hpfv) Circuits, Jeff L. Heltborg, Bethany S. Kobza, Ace Nilson

Student Research Symposium

The purpose of this study was to determine if the positioning of a nebulizer at two different locations in the VDR4, a specialty ventilator, would result in differing dose administrations of a bronchodilator, Albuterol Sulfate. We hypothesized that placement near the endotracheal tube will provide greater dose deposition. The ventilator was set up to mimic the normal adult patient. Administration was done through the nebulizer placed in the ventilator circuit either before the humidifier or between the endotracheal tube and the VDR 4’s Phasitron. Three trials were performed using a standard dose of Albuterol for each trial. The mass ...


Fiber Optic Bandage, Logan McNeil, Cameron Pilkey, Brittani Erwin, Adam Wojnar 2015 University of Tennessee - Knoxville

Fiber Optic Bandage, Logan Mcneil, Cameron Pilkey, Brittani Erwin, Adam Wojnar

Biomedical and Diagnostic Sciences Publications and Other Works

The purpose of this document is to show the report for the Fiber optic device formulated through the biomedical engineering department with a senior design group. A growing issue in medical technology is open wound care. Particularly prevalent in diabetics, open wound care is expensive and time consuming. Certain wavelengths of light have not only shown to have germicidal properties, but also allow cell growth and regeneration. The following design was founded around these ideas, and an initial design was developed. The design centered around using fiber optics as a means of replacing a wet bandage in a normal wound ...


Using Education And A Prevention Protocol Tool To Decrease The Incidence Of Pressure Ulcers In A Nursing Home, Kristina L. Scalzitti 2015 Valparaiso University

Using Education And A Prevention Protocol Tool To Decrease The Incidence Of Pressure Ulcers In A Nursing Home, Kristina L. Scalzitti

Evidence-Based Practice Project Reports

Over 1.3 million persons are residents in nursing homes (NHs); one in ten have pressure ulcers. The purpose of this evidence based practice project was to determine if implementation of a pressure ulcer prevention tool, along with staff education, decreases the incidence of pressure ulcers within the NH. Florence Nightingale’s Environmental Model and the Stetler Model were used to guide this project. The setting was a NH in northwest Indiana. Eleven nurses attended a 15 minute educational session on pressure ulcer prevention and implementation of the Pressure Ulcer Prevention Protocol Intervention (PUPPI) tool. PowerPoint slides were distributed and ...


The Characterization Of Amyloid Fibrils And Novel Synthetic Heparin-Binding Peptides Binding To Cell Surfaces, Nicole Marie Hackenbrack 2015 University of Tennessee, Knoxville

The Characterization Of Amyloid Fibrils And Novel Synthetic Heparin-Binding Peptides Binding To Cell Surfaces, Nicole Marie Hackenbrack

University of Tennessee Honors Thesis Projects

No abstract provided.


Fiber Optic Bandage, Logan McNeil 2015 University of Tennessee, Knoxville

Fiber Optic Bandage, Logan Mcneil

University of Tennessee Honors Thesis Projects

No abstract provided.


Oral Wellness: Using Occupational Therapy To Enhance Oral Hygiene Delivery In Long-Term Care, Lauryn J. Banovitz, Liberty Bellah, Rosemarie Lion 2015 Dominican University of California

Oral Wellness: Using Occupational Therapy To Enhance Oral Hygiene Delivery In Long-Term Care, Lauryn J. Banovitz, Liberty Bellah, Rosemarie Lion

Master's Theses and Capstone Projects

Based on current literature, oral health in long-term care (LTC) facilities is frequently of low priority and does not follow evidence-based best practices. Poor oral health reduces the quality of life of older adult residents and patients and can lead to systemic diseases, such as cardiovascular disease, stroke, and pneumonia, the leading cause of death in LTC. Occupational therapists can play an instrumental role as oral care consultants, and educators, and can act as resource guides to raise the standards of oral care in LTC facilities.

This capstone project explored ways in which occupational therapy, a profession traditionally designated for ...


Development And Validation Of An Unobtrusive, Continuous Model Of Loneliness Among Older Adults, Johanna Petersen Austin 2015 Oregon Health & Science University

Development And Validation Of An Unobtrusive, Continuous Model Of Loneliness Among Older Adults, Johanna Petersen Austin

Scholar Archive

Socialization is a very important part of healthy aging, but due to normal changes in health and life style, elderly individuals are at increased risk of becoming lonely—a qualitative state characterized by a subjective deficit in the social relationships. In the elderly, loneliness predicts morbidity and mortality [1-3], is associated with decreased cognitive functioning [4], impairs sleep quality [5, 6], decreases mobility [7, 8], and reduces quality of life. As a result, it is increasingly important to identify and assist lonely individuals. While surveys exist to measure loneliness [9, 10], they are given in a sporadic, infrequent, and impersonal ...


The Importance Of A Pictorial Medical History In Assisting Medical Diagnosis Of Individuals With Intellectual Disabilities: A Telemedicine Approach, Grace Bonanno 2015 Nova Southeastern University

The Importance Of A Pictorial Medical History In Assisting Medical Diagnosis Of Individuals With Intellectual Disabilities: A Telemedicine Approach, Grace Bonanno

GSCIS ETDs

When face-to-face physical medical exams are not possible, virtual physical exams, in the form of a pictorial medical exam/history, can be substituted, and telemedicine can be the means to deliver these virtual exams. The goal of this work was to determine if presence in the form of a visual and/or pictorial medical history can be of benefit to clinicians in the diagnosis of medical conditions of individuals with developmental disabilities (DDs) and/or intellectual disabilities (IDs), in particular those who cannot, because of their cognitive and/or physical disabilities, verbally relate their illness to a clinician. Virtual exams ...


A Comparison Of Cyfra 21-1, Nse, And Cea For The Serodiagnosis Of Lung Cancer, A Alexandra Knopp 2015 The University of Southern Mississippi

A Comparison Of Cyfra 21-1, Nse, And Cea For The Serodiagnosis Of Lung Cancer, A Alexandra Knopp

Honors Theses

There were 224,210 new cases of lung cancer in the US during 2014, and of those cases, there 159,260 that died from lung cancer during 2014. Since early diagnosis and treatment leads to a better prognosis, the medical community is actively looking for new, noninvasive tests for the disease. This includes the search for new and effective tumor markers. Tumor markers are used in combination with other tests to diagnose cancer. After the diagnosis, they are used to follow a patient’s case. The three tumor markers studied were neuron specific enolase (NSE), carcinoembryonic antigen (CEA), and CYFRA ...


Dynamic Simulation And Neuromuscular Control Of Movement: Applications For Predictive Simulations Of Balance Recovery, Misagh Mansouri Boroujeni 2015 University of Tennessee - Knoxville

Dynamic Simulation And Neuromuscular Control Of Movement: Applications For Predictive Simulations Of Balance Recovery, Misagh Mansouri Boroujeni

Doctoral Dissertations

Balance is among the most challenging tasks for patients with movement disorders. Study and treatment of these disorders could greatly benefit from combined software tools that offer better insights into neuromuscular biomechanics, and predictive capabilities for optimal surgical and rehabilitation treatment planning. A platform was created to combine musculoskeletal modeling, closed-loop forward dynamic simulation, optimization techniques, and neuromuscular control system design. Spinal (stretch-reflex) and supraspinal (operational space task-based) controllers were developed to test simulation-based hypotheses related to balance recovery and movement control. A corrective procedure (rectus femoris transfer surgery) was targeted for children experiencing stiff-knee gait and how this procedure ...


A Computational, Topological Approach To Icu Mortality Rate Prediction With Data Relationship Realization, Adam Michael Aaron 2015 University of Tennessee - Knoxville

A Computational, Topological Approach To Icu Mortality Rate Prediction With Data Relationship Realization, Adam Michael Aaron

Masters Theses

The objective of this work is to predict the mortality of intensive care unit patients based on their physiological data and understand the relationships between physiological data. Such a model may be used to prioritize care when resources are limited or identify patients that will need significant care in the immediate future. This effort will take a novel approach applying computational topological analysis to classify patients. The algorithm predicting the patient outcomes is trained using an evolutionary algorithm. The dataset used is from the 2012 PhysioNet Computing in Cardiology Challenge. A set containing 4000 records with outcomes was used to ...


Milk Fat Globule-Epidermal Growth Factor-Factor 8 (Mfg-E8) As A Novel Biomarker For Periodontal Disease, Fatimah A. Meshikhes 2015 University of Pennsylvania

Milk Fat Globule-Epidermal Growth Factor-Factor 8 (Mfg-E8) As A Novel Biomarker For Periodontal Disease, Fatimah A. Meshikhes

Dental Theses

AIM:

To detect the presence of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) in human gingival crevicular fluid (GCF) and to determine its potential role as a biomarker for periodontal disease activity.

MATERIALS & METHODS:

GCF was collected from a total of 230 sites from with seven subjects with gingivitis, twelve subjects with chronic moderate periodontitis, fourteen subjects with chronic severe periodontitis, six subjects with localized severe periodontitis as well as seven clinically healthy subjects. Subjects from the severe periodontitis group received nonsurgical therapy and were re-evaluated after 4 weeks. GCF was re-collected from thirty sites in five subjects at that ...


Optimization Of Fluorescent Detection Of Rotavirus Protein Nsp4 And A Cellular Receptor In Two Cell Lines, Katelyn D. Defrates, Rebecca Walker, Ron Havenar, Rebecca D. Parr 2015 Stephen F Austin State University

Optimization Of Fluorescent Detection Of Rotavirus Protein Nsp4 And A Cellular Receptor In Two Cell Lines, Katelyn D. Defrates, Rebecca Walker, Ron Havenar, Rebecca D. Parr

Bright Ideas Conference

Rotavirus (RV) infections are the most common cause of severe diarrhea in infants and young children worldwide. The two licensed vaccines for RV protect children from common strains of RV, but they are less effective against new emerging RV strains. Therefore, new therapeutics to treat RV infections need to be developed. Recently, we have shown stilbenoids, trans-arachidin-1 (t-A1) and trans-arachidin-3 (t-A3), decrease progeny virus particles by one hundred fold. Likewise, western blot assays show a decrease in the amount of the viral protein NSP4 with the addition of the stilbenoids during a RV infection. This indicates an effect on viral ...


Does Every Patient Need Colonoscopy Follow-Up For Diverticulitis?, Rachel Ackerman, Justin Yamin, Anne Foley, Louise Maranda, Benjamin Hyatt 2015 University of Massachusetts Medical School

Does Every Patient Need Colonoscopy Follow-Up For Diverticulitis?, Rachel Ackerman, Justin Yamin, Anne Foley, Louise Maranda, Benjamin Hyatt

Senior Scholars Program

Background: American College of Gastroenterology guidelines recommend colonoscopy as follow-up after an episode of diverticulitis, as there has been some association between diverticulitis and the diagnosis of colon cancer. There is limited data on the yield of this procedure in this setting. Recent studies have suggested that colonoscopy may only be warranted after episodes of complicated diverticulitis involving CT-proven abscess or reactive lymph nodes, which are associated with a higher likelihood of the presence of occult colon cancer.

Objective: The primary objective is to retrospectively examine the results of colonoscopy done for follow-up of diverticulitis at our center, specifically looking ...


Detection Of Igg4-Specific Autoantibodies In Rheumatoid Arthritis Serum Samples, Azra Borogovac, Youmna Lahoud, Janice Weaver, Sheldon M. Cooper, Mercedes Rincon, Jonathan Kay, Ellen M. Gravallese 2015 University of Massachusetts Medical School

Detection Of Igg4-Specific Autoantibodies In Rheumatoid Arthritis Serum Samples, Azra Borogovac, Youmna Lahoud, Janice Weaver, Sheldon M. Cooper, Mercedes Rincon, Jonathan Kay, Ellen M. Gravallese

Senior Scholars Program

Background: Rheumatoid arthritis (RA) is a chronic multi-system autoimmune disease characterized by inflammatory synovitis. Autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) have been implicated in the pathogenesis of RA, and are currently important criteria for diagnosis within the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria.1 Yet, many patients diagnosed with RA do not have measurable circulating ACPA or RF which may result in delayed diagnosis and treatment. After IgG1, IgG4 is the second most predominant isotype among ACPA and RF; however it is not detected in currently available diagnostic ...


Location Of All-Cause 30-Day Readmission Following Total Joint Replacement: Surgical Hospital Versus Outside Hospital, Leslie R. Harrold, David C. Ayers, Philip Noble, Regis O'Keefe, Tom Bowen, Matthew Sloan, Patricia D. Franklin 2015 University of Massachusetts Medical School

Location Of All-Cause 30-Day Readmission Following Total Joint Replacement: Surgical Hospital Versus Outside Hospital, Leslie R. Harrold, David C. Ayers, Philip Noble, Regis O'Keefe, Tom Bowen, Matthew Sloan, Patricia D. Franklin

Senior Scholars Program

Background: Evaluating posthospital complications and hospital readmissions in the United States is limited under the current system. This is due to an inability to quantify posthospital care delivered to patients at locations other than the surgical hospital. In order to circumvent this issue, information can be sought directly from patients about posthospital health care utilization. This approach provides a more complete record in comparison with methods that evaluate complications treated only at the surgical hospital.

Methods: Participants undergoing total joint replacement (TJR) between 5/10/11 and 5/17/11 were identified from the Function and Outcomes Research in Comparative ...


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