A Rationally Engineered Capsid Variant Of Aav9 For Systemic Cns-Directed And Peripheral Tissue-Detargeted Gene Delivery In Neonates, 2018 University of Massachusetts Medical School
A Rationally Engineered Capsid Variant Of Aav9 For Systemic Cns-Directed And Peripheral Tissue-Detargeted Gene Delivery In Neonates, Dan Wang, Shaoyong Li, Dominic J. Gessler, Jun Xie, Li Zhong, Jia Li, Karen Tran, Kim Van Vliet, Lingzhi Ren, Qin Su, Ran He, Jason E. Goetzmann, Terence R. Flotte, Mavis Agbandje-Mckenna, Guangping Gao
Open Access Articles
Adeno-associated virus (AAV) has provided the gene therapy field with the most powerful in vivo gene delivery vector to realize safe, efficacious, and sustainable therapeutic gene expression. Because many clinically relevant properties of AAV-based vectors are governed by the capsid, much research effort has been devoted to the development of AAV capsids for desired features. Here, we combine AAV capsid discovery from nature and rational engineering to report an AAV9 capsid variant, designated as AAV9.HR, which retains AAV9's capability to traverse the blood-brain barrier and transduce neurons. This variant shows reduced transduction in peripheral tissues when delivered through ...
2'-5'-Oligoadenylate Synthetase 1 (Oas1) And Health Disparities In Prostate Cancer, 2018 Clark Atlanta University
2'-5'-Oligoadenylate Synthetase 1 (Oas1) And Health Disparities In Prostate Cancer, Aisha S. Hunt
Electronic Theses & Dissertations Collection for Atlanta University & Clark Atlanta University
2’ -5’ –oligoadenylate synthetase 1 (OAS1) is an antiviral enzyme that in the presence of double-stranded RNA structures, such as viral genomes or single-stranded RNA transcripts with significant double-stranded character, converts ATP to a series of 2’ -5’ –oligoadenylates (2-5A). 2-5A promotes dimerization of latent ribonuclease (RNaseL) to form catalytically active RNaseL, a candidate hereditary prostate cancer (PCa) gene. RNaseL is anti-proliferative and promotes senescence and apoptosis in PCa cells. Genotyping analysis was completed on over 600 genomic DNA samples from African-American and Caucasian, normal and PCa subjects. Genotyping was performed to screen the following SNPs in the last exon ...
Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender
Student Theses 2015-Present
This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim ...
El Impacto De Las Artes Visuales En Personas Afectadas Por Cáncer, 2018 EXPLORARTE
El Impacto De Las Artes Visuales En Personas Afectadas Por Cáncer, Bettina Ingham
ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens
El impacto de las artes visuales en el bienestar y la mejora de la calidad de vida de personas afectadas por cáncer.
Un programa diseñado para poner en práctica e investigar el alcance que tienen las artes visuales y el método de Estrategias de Pensamiento Visual para el desarrollo de habilidades de pensamiento que promueven la identificación y expresión verbal de las emociones, minimizando, en el caso de las personas convalecientes, el sufrimiento que va desde el dolor de la enfermedad hasta el miedo a la muerte.
Los efectos que la contemplación (percepción estética), el análisis y la práctica(proceso ...
Design Of A Distributed Real-Time E-Health Cyber Ecosystem With Collective Actions: Diagnosis, Dynamic Queueing, And Decision Making, 2018 University of Nebraska - Lincoln
Design Of A Distributed Real-Time E-Health Cyber Ecosystem With Collective Actions: Diagnosis, Dynamic Queueing, And Decision Making, Yanlin Zhou
Theses, Dissertations, and Student Research from Electrical & Computer Engineering
In this thesis, we develop a framework for E-health Cyber Ecosystems, and look into different involved actors. The three interested parties in the ecosystem including patients, doctors, and healthcare providers are discussed in 3 different phases. In Phase 1, machine-learning based modeling and simulation analysis is performed to remotely predict a patient's risk level of having heart diseases in real time. In Phase 2, an online dynamic queueing model is devised to pair doctors with patients having high risk levels (diagnosed in Phase 1) to confirm the risk, and provide help. In Phase 3, a decision making paradigm is ...
Structure Determination Of A Bioengineered Human/Porcine Factor Viii For Hemophilia A Treatment, And Improvements To The Human Factor Viii Model, 2018 Western Washington University
Structure Determination Of A Bioengineered Human/Porcine Factor Viii For Hemophilia A Treatment, And Improvements To The Human Factor Viii Model, Ian Smith
Graduate Student Symposium
Blood coagulation factor VIII (FVIII), is a non-enzymatic cofactor which plays a crucial role in the formation of a stable blood clot. Absence or deficiency of FVIII results in the blood disorder hemophilia A; with symptoms including internal hemorrhaging and the inability to stop bleeding from open wounds. Treatment of hemophilia A relies on infusions of blood, plasma, or protein concentrates to replace FVIII. Unfortunately, approximately 30% of patients receiving replacement FVIII generate pathologic anti-FVIII inhibitory antibodies, which both reduce the effectiveness of the FVIII therapeutic and increase the severity of hemophilia A symptoms. We have determined the molecular structure ...
A Case Of Signet Ring Cell Colon Carcinoma Initially Presenting As Acute Diverticulitis, 2018 Rowan University SOM
A Case Of Signet Ring Cell Colon Carcinoma Initially Presenting As Acute Diverticulitis, Justin Derosa Do, Jonathan Foster Do, Drew Chiesa Do, Darshan Roy Md
Stratford Campus Research Day
This is a unique case of a female with an acute bout of diverticulitis who six weeks later on follow up colonoscopy, was found to have signet ring cell colon carcinoma. The purpose is to deliver awareness of this rare type of colon malignancy, emphasize the continued need for screening colonoscopy, and to provide the reader with a distinct and thought provoking spin on the conventional diagnosis of diverticulitis.
Spectral Properties Of Doxorubicin Doped Rhdl Nanoparticles, 2018 University of North Texas Health Science Center at Fort Worth
Spectral Properties Of Doxorubicin Doped Rhdl Nanoparticles, Sunil Shah
Theses and Dissertations
Doxorubicin, also known as Adriamycin, is an anthracycline antibiotic which first gained clinical prominence in the early 1970’s as an effective antitumor agent. It is still used today to treat a spectrum of cancers like lymphoma, bladder, stomach, lung, breast, ovarian, and several others. Due to its production of free radicals to attack tumor cells, Doxorubicin interferes with mitochondrial phosphorylation and also induces cardiotoxicity. Thus, efficient and biocompatible delivery methods are needed for targeted drug delivery to overcome systemic toxicity. To maintain a high level of growth, tumor cells overexpress Scavenger receptors type B-1 (SR-B1). This cellular characteristic can ...
Analysis Of Patient Recruitment Methods For Clinical Trials Of Different Heart And Lung Diseases, 2018 University of North Texas Health Science Center at Fort Worth
Analysis Of Patient Recruitment Methods For Clinical Trials Of Different Heart And Lung Diseases, Oghenevovwero Vovwe Sido
Theses and Dissertations
Patient recruitment is key to the success of any clinical trial, as clinical trials cannot be conducted without the willful participation of subjects. However, clinical trial recruitment has always been a great challenge in clinical studies. This practicum project conducted over an eight-month period, compares three different methods of subject recruitment into 2 clinical research studies conducted at the Heart & Lung Transplant and Pulmonary Research Department of Baylor Scott & White Research Institute, Dallas. The three recruitment methods are: Physician Referral, EHR Screening and Online Portals. We hypothesize that Physician referral is a more successful method for enrolling patients into clinical ...
In Vitro Aortic Arch Flow Model For Vector Flow Imaging Testing, 2018 University of Arkansas, Fayetteville
In Vitro Aortic Arch Flow Model For Vector Flow Imaging Testing, Jackson Mosley
Biomedical Engineering Undergraduate Honors Theses
Pediatric stenosis is the narrowing of the aorta at the aortic valve, above the aortic valve, or below the aortic valve. Typically, this disease’s severity is diagnosed by conventional Doppler ultrasound methods, or echocardiography. Conventional Doppler can sometimes overestimate the pressure gradient over the area of stenosis, diagnosing some cases of PAS to be more severe than they actually are. This causes earlier intervention than is desired in children. A new US modality, Vector Flow Imaging (VFI), is an angle-independent US imaging method that can potentially more accurately quantify peak blood flow velocities and pressure gradients across stenotic sections ...
Design And Development Of A Quartz Crystal Microbalance Immunosensor For Exosomes, 2018 University of Tennessee, Knoxville
Design And Development Of A Quartz Crystal Microbalance Immunosensor For Exosomes, Wesley Cox
University of Tennessee Honors Thesis Projects
No abstract provided.
Policy Of Current Hospital Translation Services And Recommendations For Future Adjustments For Spanish-Speaking Patients, 2018 University of Tennessee, Knoxville
Policy Of Current Hospital Translation Services And Recommendations For Future Adjustments For Spanish-Speaking Patients, Isidora Rose Beach
University of Tennessee Honors Thesis Projects
No abstract provided.
The Dancing Nurse: Addressing Barriers To The Implementation Of Movement-Based Interventions In Holistic Patient Care, 2018 Oral Roberts University
The Dancing Nurse: Addressing Barriers To The Implementation Of Movement-Based Interventions In Holistic Patient Care, Jessica Collier, Audrey Thompson Phd
Nursing Undergraduate Work
The efficacy of dance movement therapy (DMT) is well demonstrated in contemporary nursing literature; however, implementation by healthcare professionals is often limited. Dance movement therapy was pioneered in the mid-20th century by classically trained modern dancer Marian Chace. Recent trends toward patient-centered care and interdisciplinary approaches render therapies such as DMT important modalities which nurses and other healthcare providers may become familiar with. This systematic research review focused on answering the question: “what are hindrances perceived by members of the healthcare team to implementing DMT as an alternative treatment modality?” Two variables were identified for the purposes of this ...
Insane: James Holmes, Clark V. Arizona, And America's Insanity Defense, 2018 Cleveland-Marshall College of Law
Insane: James Holmes, Clark V. Arizona, And America's Insanity Defense, Eric Collins
Journal of Law and Health
Insanity is a legal term of art that changes definitions depending on the legal standard in American jurisprudence, which explains why a man who mental health professionals described as having an uncontrollable obsession with killing people can be found not insane and guilty. This Note addresses the current state of the Insanity Defense Reform Act of 1984 and its widespread implementation at the state level. Part II supplies background information on the history of the insanity defense and how it has transformed over the years in American jurisprudence. Part III provides an analysis of the of the insanity defense. Part ...
The Test-Retest Reliability Of Erp Components As Assessed By The Brief Neurometric Battery, 2018 The College of William and Mary
The Test-Retest Reliability Of Erp Components As Assessed By The Brief Neurometric Battery, James D. Cole, Paul Kieffaber
Undergraduate Honors Theses
Electroencephalography (EEG) has been a crucial component of neuropsychological research for nearly a century. Recent applications of the EEG recordings in a clinical setting have demonstrated a range of diagnostic and prognostic uses. Certain changes in event-related potentials (ERP) have been linked to the effects of different neurological conditions and can be accurately used to determine the severity of those conditions. However, in order to assess the stability of these ERP recordings over an extended period of time, one must first establish their statistical test-retest reliability. Using a novel Brief Neurometric Battery we assessed seven different ERP components in twenty ...
A Functional Near Infrared Spectroscopy (Fnirs) Replication Of The Sunscreen Persuasion Paradigm, 2018 University of Pennsylvania
A Functional Near Infrared Spectroscopy (Fnirs) Replication Of The Sunscreen Persuasion Paradigm, Shannon M. Burns, Lianne N. Barnes, Perri L. Katzman, Daniel L. Ames, Emily B. Falk, Matthew D. Lieberman
Departmental Papers (ASC)
Activity in medial prefrontal cortex (mPFC) during persuasive messages predicts future message-consistent behavior change, but there are significant limitations to the types of persuasion processes that can be invoked inside an MRI scanner. For instance, real world persuasion often involves multiple people in conversation. Functional near infrared spectroscopy (fNIRS) allows us to move out of the scanner and into more ecologically valid contexts. As a first step, the current study used fNIRS to replicate an existing fMRI persuasion paradigm (i.e. the sunscreen paradigm) to determine if mPFC shows similar predictive value with this technology. Consistent with prior fMRI work ...
Use Of Urine Antigen Testing For Blastomyces In An Integrated Health System, 2018 Aurora UW Medical Group, Aurora Health Care
Use Of Urine Antigen Testing For Blastomyces In An Integrated Health System, Dennis J. Baumgardner
Journal of Patient-Centered Research and Reviews
Purpose: Blastomycosis, an endemic fungal infection, mimics many other diseases. We explored the use of Blastomyces urine antigen (BuAg), reportedly the most sensitive noninvasive test, in clinical practice and compared it to other noninvasive tests.
Methods: A total of 836 BuAg tests performed on unique patients (first test only) at one large integrated health system from June 2013 to May 2016 were retrospectively reviewed to examine test characteristics and demographic features. Of these, 100 cases from 2015, a year containing a large local blastomycosis outbreak, were randomly selected for detailed analysis.
Results: Demographics for the BuAg-tested population: mean age 54 ...
Open Cycle: Forecasting Ovulation For Family Planning, 2018 Southern Methodist University
Open Cycle: Forecasting Ovulation For Family Planning, Karen Clark, Mridul Jain, Araya Messa, Vinh Le, Eric C. Larson
SMU Data Science Review
Abstract: Forecasting the length and different phases of a woman’s menstrual cycle, especially ovulation, is an important aspect of family planning. Predicting fertility has many uses in family planning including avoiding pregnancy and assisting couples in becoming pregnant. Past methods have focused on monitoring basal body temperature (BBT), cervical mucus changes, and hormonal levels to determine fertility. While these methods can provide an accurate prediction of ovulation these tests can become expensive, time-consuming, and do not provide prediction until after ovulation has occurred. In this paper, we compare conventional fertility assessment that is based on a rule known as ...
Quantifying Nitric Oxide Production In Platelets Using A Griess Reagent System, 2018 Lynchburg College
Quantifying Nitric Oxide Production In Platelets Using A Griess Reagent System, Chelsea Shultis
Undergraduate Theses and Capstone Projects
Nitric oxide (NO) is a signaling molecule that regulates many physiological processes in the human body. Common examples of processes that NO is involved in range from immune responses to the regulation of blood pressure. In intact blood vessels, nitric oxide is constitutively released by vascular endothelial cells in order to prevent platelet adhesion and clot formation. Platelets have also been shown to release small amounts of NO as they aggregate on damaged blood vessels. Platelet-derived NO is hypothesized to play an important role in limiting the extent of clot formation. Although platelets produce nitric oxide during aggregation, it is ...
Effects Of Psychiatric Comorbidities On The Perioperative Outcomes Following A Primary Total Arthroplasty, Taylor Smith
Carroll College Student Undergraduate Research Festival
This review was conducted to compare the perioperative outcomes following a total primary arthroplasty among patients with a psychiatric comorbidity versus those without a psychiatric comorbidity. Literature was reviewed from the database Pubmed. Seven cohort and case-control studies were reviewed, with the largest sample size of 8.4 million patients. Psychiatric comorbidities resulted in increased negative perioperative outcomes compared to patients without psychiatric comorbidities in six articles. These studies observed higher rates of revision, blood transfusion, mortality, non-traditional discharge, and increased length and cost of stay for patients with a diagnosed psychiatric condition. Therefore, it was concluded from most studies ...