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Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons

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A Systematic Review Of Dual-Sensory Impairment In Older Adults, Abby F. Malawer 2016 Graduate Center, City University of New York

A Systematic Review Of Dual-Sensory Impairment In Older Adults, Abby F. Malawer

All Dissertations, Theses, and Capstone Projects (2014-Present)

The elderly population (ages 65 years and older) in the United States is estimated to double between 2000 and 2030 to approximately 72 million people. Among this population, sensory impairment is a chronic disability. The combination of both hearing and vision impairment, referred to as dual-sensory impairment (DSI) is a chronic condition on the rise. The prevalence of DSI ranges from a low of 1.6% to as high as 22.5% depending on the population (Appollonio et al., 1995). Higher prevalence rates tend to emerge in populations receiving rehabilitative and hospital care. DSI impacts independent physical function and verbal ...


Reliability Of Clinical Evaluators Of Spasticity In Patients With Stroke, Tiffany Alvino, Shiney David, Chelsea Gendvil 2016 Graduate Center, City University of New York

Reliability Of Clinical Evaluators Of Spasticity In Patients With Stroke, Tiffany Alvino, Shiney David, Chelsea Gendvil

All Dissertations, Theses, and Capstone Projects (2014-Present)

Spasticity is characterized by hyperexcitable stretch reflexes with amplitude increases in response to velocity dependent passive movement and resistance. Spasticity is the result of abnormal function of segmental and suprasegmental neuronal circuits. The objective of this study was to determine any positive correlation between three clinical evaluators of spasticity (i.e., the pendulum test, the patellar tendon tap test (PTT), and the Modified Ashworth scale) in their reliability to assess spasticity in people post-stroke. It was hypothesized that the use of force movement sensors along with surface electromyography increases the reliability of the standardized clinical tests. The results show that ...


Global Dynamics Of A Model Of Joint Hormone Treatment With Dendritic Cell Vaccine For Prostate Cancer, Erica M. Rutter, Yang Kuang 2016 Arizona State University at the Tempe Campus

Global Dynamics Of A Model Of Joint Hormone Treatment With Dendritic Cell Vaccine For Prostate Cancer, Erica M. Rutter, Yang Kuang

Biology and Medicine Through Mathematics Conference

No abstract provided.


Patient-Specific Inference Of Average Glucose From Glycated Hemoglobin, Roy Malka, David M. Nathan, John M. Higgins 2016 Massachusetts General Hospital

Patient-Specific Inference Of Average Glucose From Glycated Hemoglobin, Roy Malka, David M. Nathan, John M. Higgins

Biology and Medicine Through Mathematics Conference

No abstract provided.


An Approach To Collect Non-Standard Microdialysis Compounds, Allison M. Schneider 2016 University of Arkansas, Fayetteville

An Approach To Collect Non-Standard Microdialysis Compounds, Allison M. Schneider

Chemistry & Biochemistry Undergraduate Honors Theses

Microdialysis is a sampling technique that is used to collect analytes through a semipermeable membrane. The collection occurs via the microdialysis probe where analytes can diffuse through the membrane and be collected by use of the outlet. Microdialysis is typically utilized with solutes that are hydrophilic and have a low molecular weight. It is unusual for hydrophobic solutes to be used, but pentane, a hydrophobic analyte, was studied in this research to see if non-standard microdialysis compounds can be collected. This is important because the pentane resembles hydrophobic signaling molecules in the brain, such as prostaglandins and leukotrienes and can ...


Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum 2016 University of Nebraska - Lincoln

Diffusion Modeling And Device Development For Peritoneal Membrane Oxygenation, Liana Hatoum

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Acute respiratory distress syndrome (ARDS) is a pulmonary disease that causes hypoxemia and respiratory failure. The mortality rate for ARDS ranges between 27% and 45%. Current treatments including mechanical ventilation and extracorporeal membrane oxygenation (ECMO) are often associated with high risk complications including barotrauma, infection, thrombosis, and hemorrhage. Alternative pulmonary support techniques are needed to improve the survival rate of patients suffering from ARDS. Previous studies introducing pure O2 gas, perfluorocarbons and red blood cells into the intraperitoneal (IP) cavity have reported no effect or only a mild increase in oxygenation. Here we report peritoneal membrane oxygenation (PMO) using ...


Design Of Medical Devices For Diagnostics In The Gastrointestinal System, Charles R. Welch 2016 University of Nebraska-Lincoln

Design Of Medical Devices For Diagnostics In The Gastrointestinal System, Charles R. Welch

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

This thesis presents the design, controls, and testing of two systems: a novel colonoscope locomotion design for diagnostics, and a biosensor capsule that implants a sensor in the small intestine. Each system requires special design considerations for use in the gastrointestinal system.

Colonoscopy procedures are recommended as a screening for colon cancer and related conditions after the age of 50. The need for an improved colonoscope that reduces the colonoscopy time and patient discomfort is apparent. The semi-autonomous device presented here could likely reduce the colonoscopy procedure time by allowing the physician to focus more on the diagnosis and less ...


Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg 2016 Cedarville University

Effects Of Antiepileptic Medications On Bone Density In Individuals With Intellectual And Developmental Disabilities, Carly R. Gregory, Hannah L. Stedge, Robyn K. Brandenburg

The Research and Scholarship Symposium

Individuals with intellectual and developmental disabilities (IDD) are commonly prescribed antiepileptic drugs (AEDs) to manage seizures, manage behavior, and stabilize mood. Though research has been done on the effects of antiepileptic medications in patients with epilepsy, little study has been done on the persons with intellectual and developmental disabilities population. After surveying IDD patients with a history and current use of AEDs on osteoprotective behaviors, we were unable to use SPSS due to incomplete surveys and low sample sizes. However, we were still able to analyze for common themes, and we found that the most prevalent use of AEDs was ...


Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, MD, Chadwick J. Knight, MD 2016 Marshall University

Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, Md, Chadwick J. Knight, Md

Marshall Journal of Medicine

Abdominal trauma can be mysterious to some physicians. If patients are evaluated for being stable or unstable, then abdominal trauma can be easily managed. Using a combination of physical examination, ultrasound and CT scans, patients can be quickly and efficiently evaluated.


Exploration Of Franklin D. Roosevelt's Paralytic Illness, Tara Malik 2016 Georgia State University

Exploration Of Franklin D. Roosevelt's Paralytic Illness, Tara Malik

Georgia State Undergraduate Research Conference

No abstract provided.


The Importance Of Including Co-Factor Information When Reporting Resting Heart Rate, John Hart 2016 Sherman College of Chiropractic

The Importance Of Including Co-Factor Information When Reporting Resting Heart Rate, John Hart

Internet Journal of Allied Health Sciences and Practice

Resting heart rate, sometimes referred to as resting pulse rate (RPR) is taken for various reasons in the various health care professions. As with many physiological tests, there are a number of basic factors that can affect RPR, such as gender and position of the patient during measurement. In most papers, these basic factors are included but in some they are not. If such information is lacking, the meaningfulness of the reported RPR is diminished. The purpose of this manuscript is to highlight the importance of including such information when reporting on RPR data.


Clinical Informatics : Recursive Concurrence Intravenous Medication Administration Systems Protocols For Addressing The Potential Problem Of Recessive Lethal Autonomy In Smart Infusion Systems, Nyagudi Nyagudi 2016 Independent Contractor - Litigation Support

Clinical Informatics : Recursive Concurrence Intravenous Medication Administration Systems Protocols For Addressing The Potential Problem Of Recessive Lethal Autonomy In Smart Infusion Systems, Nyagudi Nyagudi

Nyagudi M Nyagudi, B.Sc. Math & Phy (Nairobi, 1997), M.Sc. Info. Sys. (Notarized Equiv. of Nairobi, 2015)

Clinical Informatics: Recursive Concurrence Intravenous Medication Administration Systems Protocols for Addressing the Potential Problem of Recessive Lethal Autonomy in Smart Infusion Systems


Using Mixed Methods To Measure The Perception Of Community Capacity In An Academic–Community Partnership For A Walking Intervention, Charkarra Anderson-Lewis, Diana Castellanos, Arnecca Byrd, Karen Zynda, Alicia Sample, Vickie Reed, Mary Beard, Latessa Minor, Kathleen Yadrick 2016 University of Southern Mississippi

Using Mixed Methods To Measure The Perception Of Community Capacity In An Academic–Community Partnership For A Walking Intervention, Charkarra Anderson-Lewis, Diana Castellanos, Arnecca Byrd, Karen Zynda, Alicia Sample, Vickie Reed, Mary Beard, Latessa Minor, Kathleen Yadrick

Diana Cuy Castellanos

H.U.B. City Steps is a 5-year community-based participatory research walking intervention designed to help lower blood pressure in a majority African American population in southern Mississippi via community collaboration and capacity building, increased walking, culturally tailored health education sessions, and motivational interviewing. Building community capacity for physical activity is a key component of this intervention. Qualitative and quantitative methods have been used to assess how project stakeholders perceive the community capacity-building efforts of the project. This article illustrates the baseline results of this mixed methods approach from the perspective of three groups of stakeholders: project researchers and staff ...


Detecting Heart Failure Decompensation By Measuring Transthoracic Bioimpedance In The Outpatient Setting: Rationale And Design Of The Sentinel-Hf Study, Silviu Dovancescu, Jane Saczynski, Chad Darling, Jarno Riistema, Fatima Kuniyoshi, Theo Meyer, Robert Goldberg, David McManus 2016 Philips Research

Detecting Heart Failure Decompensation By Measuring Transthoracic Bioimpedance In The Outpatient Setting: Rationale And Design Of The Sentinel-Hf Study, Silviu Dovancescu, Jane Saczynski, Chad Darling, Jarno Riistema, Fatima Kuniyoshi, Theo Meyer, Robert Goldberg, David Mcmanus

David D. McManus

BACKGROUND: Recurrent hospital admissions are common among patients admitted for acute decompensated heart failure (ADHF), but identification of patients at risk for rehospitalization remains challenging. Contemporary heart failure (HF) management programs have shown modest ability to reduce readmissions, partly because they monitor signs or symptoms of HF worsening that appear late during decompensation. Detecting early stages of HF decompensation might allow for immediate application of effective HF therapies, thereby potentially reducing HF readmissions. One of the earliest indicators of HF decompensation is intrathoracic fluid accumulation, which can be assessed using transthoracic bioimpedance.

OBJECTIVE: The SENTINEL-HF study is a prospective observational ...


Protein Arginine Methylation And Citrullination In Epigenetic Regulation, Jakob Fuhrmann, Paul R. Thompson 2016 The Scripps Research Institute

Protein Arginine Methylation And Citrullination In Epigenetic Regulation, Jakob Fuhrmann, Paul R. Thompson

Thompson Lab Publications

The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states.


Enhancing Informative Frame Filtering By Water And Bubble Detection In Colonoscopy Videos, Ashok Dahal, JungHwan Oh, Wallapak Tavanapong, Johnny Wong, Piet de Groen 2016 University of North Texas

Enhancing Informative Frame Filtering By Water And Bubble Detection In Colonoscopy Videos, Ashok Dahal, Junghwan Oh, Wallapak Tavanapong, Johnny Wong, Piet De Groen

Wallapak Tavanapong

Colonoscopy has contributed to a marked decline in the number of colorectal cancer related deaths. However, recent data suggest that there is a significant (4-12%) miss-rate for the detection of even large polyps and cancers. To address this, we have been investigating an ‘automated feedback system’ which informs the endoscopist of possible sub-optimal inspection during colonoscopy. A fundamental step of this system is to distinguish non-informative frames from informative ones. Existing methods for this cannot classify water/bubble frames as non-informative even though they do not carry any useful visual information of the colon mucosa. In this paper, we propose ...


Cable Footprint History: Spatio-Temporal Technique For Instrument Detection In Gastrointestinal Endoscopic Procedures, Chuanhai Zhang, Wallapak Tavanapong, Johnny Wong, Piet de Groen, JungHwan Oh 2016 Iowa State University

Cable Footprint History: Spatio-Temporal Technique For Instrument Detection In Gastrointestinal Endoscopic Procedures, Chuanhai Zhang, Wallapak Tavanapong, Johnny Wong, Piet De Groen, Junghwan Oh

Wallapak Tavanapong

We propose a new fast spatio-temporal technique that detects an operation scene---a video segment corresponding to a single purpose diagnosis action or a single purpose therapeutic action. The technique utilizes (1) color contrast of the cable region and the background, (2) the new area-based coordinate system to compute spatial features, and (3) the history of locations of detected cables of the instrument in a video to discard false regions. The proposed technique and software are useful for (1) automatic documentation of diagnostic or therapeutic operations at the end of the procedure, (2) a second review for causes of complications due ...


Who Should Receive Extended Infusion Beta-Lactam Therapy?, Christopher Roman, Tia Sloth, Kendra Damer 2016 Butler University

Who Should Receive Extended Infusion Beta-Lactam Therapy?, Christopher Roman, Tia Sloth, Kendra Damer

Christopher Roman

The increasing prevalence of antibiotic-resistant bacteria challenges a clinician's ability to fight life-threatening infections. Administering beta-lactams via extended infusion may improve patient outcomes. This article discusses the underlying principles of this therapeutic approach and when it may be appropriate.


Development And Validation Of A Preprocedural Risk Score To Predict Access Site Complications After Peripheral Vascular Interventions Based On The Vascular Quality Initiative Database, Daniel Ortiz, Maharaj Singh, Arshad Jahangir, Suhail Allaqaband, Anjan Gupta, Tanvir Bajwa, Mark W. Mewissen 2016 Aurora Health Care

Development And Validation Of A Preprocedural Risk Score To Predict Access Site Complications After Peripheral Vascular Interventions Based On The Vascular Quality Initiative Database, Daniel Ortiz, Maharaj Singh, Arshad Jahangir, Suhail Allaqaband, Anjan Gupta, Tanvir Bajwa, Mark W. Mewissen

Arshad Jahangir, MD

Purpose

Access site complications following peripheral vascular intervention (PVI) are associated with prolonged hospitalization and increased mortality. Prediction of access site complication risk may optimize PVI care; however, there is no tool designed for this. We aimed to create a clinical scoring tool to stratify patients according to their risk of developing access site complications after PVI.

Methods

The Society for Vascular Surgery’s Vascular Quality Initiative database yielded 27,997 patients who had undergone PVI at 131 North American centers. Clinically and statistically significant preprocedural risk factors associated with in-hospital, post-PVI access site complications were included in a multivariate ...


Volume Averaging Of Spectral-Domain Optical Coherence Tomography Impacts Retinal Segmentation In Children, Carmelina Trimboli-Heidler, Kelly Vogt, Robert A. Avery 2016 George Washington University

Volume Averaging Of Spectral-Domain Optical Coherence Tomography Impacts Retinal Segmentation In Children, Carmelina Trimboli-Heidler, Kelly Vogt, Robert A. Avery

GW Research Days 2016 - Present

Purpose: To determine the influence of volume averaging on retinal layer thickness measures acquired with spectral-domain optical coherence tomography (SD-OCT) in children.

Methods: Macular SD-OCT images were acquired using three different volume acquisition settings (i.e., ART 1, 3, and 9 volumes) in children enrolled in a prospective OCT study. Total retinal, retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer, and outer plexiform layer thicknesses were measured around an ETDRS grid using beta version automated segmentation software for the Spectralis. The magnitude of manual segmentation required to correct the automated segmentation was classified as either ...


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