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Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons

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Design And Development Of A Miniature In Vivo Surgical Robot With Distributed Motor Control For Laparoendoscopic Single-Site Surgery, Eric J. Markvicka 2014 University of Nebraska - Lincoln

Design And Development Of A Miniature In Vivo Surgical Robot With Distributed Motor Control For Laparoendoscopic Single-Site Surgery, Eric J. Markvicka

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Paradigm shifts in invasiveness, recovery time, cosmesis, and cost have been seen within the field of general surgery through major advances in surgical technology. Some of the most advanced types of general surgery now include Minimally Invasive Surgery (MIS), LaparoEndoscopic Single-Site (LESS) surgery, and Natural Orifice Translumenal Endoscopic Surgery (NOTES). One of the newest and rapidly developing catalysts is robotic platforms. Such platforms have improved ergonomics and control, increased workspace and dexterity, and have surpassed the efficacy of many non-robotic platforms such as traditional laparoscopic surgical tools. This thesis presents the design and development of a four-degree-of-freedom (4- DOF) miniature ...


Towards Highly-Integrated Stereovideoscopy For In Vivo Surgical Robots, Jay Carlson 2014 University of Nebraska - Lincoln

Towards Highly-Integrated Stereovideoscopy For In Vivo Surgical Robots, Jay Carlson

Electrical Engineering Theses and Dissertations

When compared to traditional surgery, laparoscopic procedures result in better patient outcomes: shorter recovery, reduced post-operative pain, and less trauma to incisioned tissue. Unfortunately, laparoscopic procedures require specialized training for surgeons, as these minimally-invasive procedures provide an operating environment that has limited dexterity and limited vision. Advanced surgical robotics platforms can make minimally-invasive techniques safer and easier for the surgeon to complete successfully. The most common type of surgical robotics platforms -- the laparoscopic robots -- accomplish this with multi-degree-of-freedom manipulators that are capable of a diversified set of movements when compared to traditional laparoscopic instruments. Also, these laparoscopic robots allow for ...


Fluid Powered Miniature In-Vivo Robots For Minimally Invasive Surgery (Mis), Abolfazl Pourghodrat 2014 University of Nebraska - Lincoln

Fluid Powered Miniature In-Vivo Robots For Minimally Invasive Surgery (Mis), Abolfazl Pourghodrat

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Minimizing the invasiveness of surgery is believed to improve patient outcomes. Bleeding, infection, and pain are major concerns in surgery afflicting patients for decades. Minimally invasive techniques have come into play to reduce these concerns and smooth the evolution of abdominal surgery to a scarless process where nearly all surgeries can be performed without a skin incision. Technology continually advances the frontier of development of novel surgical devices to implement less invasive surgical techniques.

Fusion of robotics and Minimally Invasive Surgery (MIS) has created new opportunities to develop diagnostic and therapeutic tools. Surgical robotics is advancing from externally actuated systems ...


Production Of Recombinant Human Coagulation Factor Ix By Transgenic Pig, Weijie Xu 2014 University of Nebraska - Lincoln

Production Of Recombinant Human Coagulation Factor Ix By Transgenic Pig, Weijie Xu

Chemical & Biomolecular Engineering Theses, Dissertations, & Student Research

Hemophilia B is the congenital bleeding disorder caused by deficiency in functional coagulation factor IX (FIX) and about 28,000 patients worldwide in 2012. And current treatment is restricted to protein-replacement therapy, which required FIX concentrates for patients’ life-time. Approximately 1 billion units FIX were consumed in 2012. However, still about 70-80% patients, mostly in developing countries, received inadequate or no treatment because of the unavailable and/or unaffordable FIX concentrates. Considering safety reasons, e.g. transmission of blood-borne diseases, the recombinant human FIX (rFIX) is recommended other than the plasma-derived FIX. However, only one rFIX is currently available on ...


Predictors Of Pain Relief Following Spinal Cord Stimulation In Chronic Back And Leg Pain And Failed Back Surgery Syndrome: A Systematic Review And Meta-Regression Analysis, Rod S. Taylor, Mehul J. Desai, Philippe Rigoard, Rebecca J. Taylor 2014 Himmelfarb Health Sciences Library, The George Washington University

Predictors Of Pain Relief Following Spinal Cord Stimulation In Chronic Back And Leg Pain And Failed Back Surgery Syndrome: A Systematic Review And Meta-Regression Analysis, Rod S. Taylor, Mehul J. Desai, Philippe Rigoard, Rebecca J. Taylor

Anesthesiology and Critical Care Medicine Faculty Publications

We sought to assess the extent to which pain relief in chronic back and leg pain ( CBLP) following spinal cord stimulation ( SCS) is influenced by patient-related factors, including pain location, and technology factors. A number of electronic databases were searched with citation searching of included papers and recent systematic reviews. All study designs were included. The primary outcome was pain relief following SCS, we also sought pain score (pre- and post- SCS). Multiple predictive factors were examined: location of pain, history of back surgery, initial level of pain, litigation/worker's compensation, age, gender, duration of pain, duration of follow-up ...


Application Of Nuclear Magnetic Resonance Based Metabolomics To Study The Central Metabolism Of Staphylococci, Bo Zhang 2014 University of Nebraska - Lincoln

Application Of Nuclear Magnetic Resonance Based Metabolomics To Study The Central Metabolism Of Staphylococci, Bo Zhang

Student Research Projects, Dissertations, and Theses - Chemistry Department

Metabolomics studies the collection of small molecules (metabolites) involved in enzymatically catalyzed reactions, cell signaling and cellular structure. Perturbations in metabolite concentrations have been used to reflect the activity of corresponding enzymes or proteins. Nuclear magnetic resonance (NMR) spectroscopy is a well-known approach for the structure determination of biological macromolecules. Alternatively, NMR has recently been established as a valuable tool of metabolomics, in which NMR spectral signals correlate small molecules with cellular activities. This has been accomplished through the chemometric analysis of high-throughput one dimensional 1H spectra (metabolic fingerprinting) and quantitative metabolite identification based on two dimensional 1H ...


Characterizing The Response Of Multidrug-Resistant Klebsiella Pneumoniae Species To The Application Of A Phage Cocktail, Steven Liu 2014 California Polytechnic State University

Characterizing The Response Of Multidrug-Resistant Klebsiella Pneumoniae Species To The Application Of A Phage Cocktail, Steven Liu

Symposium

Project Summary: The application of bacteriophages to treat bacterial infections is known as phage therapy, which takes advantage of bacteriophage’s natural ability to infect and lyse bacterial hosts. Phages have been shaped by billions of years of evolution to be highly specialized deliverers of bactericidal agents to the cytoplasm of their target bacteria. Ever since discovery of bacteriophages in 1915, phage therapy was recognized as a potentially powerful tool for eliminating bacterial infections. The effectiveness of phage therapy can be increased by creating a mixture of multiple phages to target a wider variety of bacterial strains. Furthermore, phage therapy ...


Understanding The Last Days Of Life: Information And Resources For Patients And Family Members, Penny Glassman 2014 University of Massachusetts Medical School

Understanding The Last Days Of Life: Information And Resources For Patients And Family Members, Penny Glassman

Library Publications and Presentations

The purpose of this article is to describe my experience during the last few days of my father's life. My father had been suffering with dementia for approximately eight years. As a family, we worked together to plan his care. However, we were not prepared for his last days of life. Understanding the process helped me cope with the end of my father's life. The end of the article includes links to some freely available resources to help you, your family, and your patrons.


An Investigation Of Poly(N-Isopropylacrylamide) For Applications With Microfluidic Paper-Based Analytical Devices, Haydn Thomas Mitchell 2014 California Polytechnic State University

An Investigation Of Poly(N-Isopropylacrylamide) For Applications With Microfluidic Paper-Based Analytical Devices, Haydn Thomas Mitchell

Master's Theses and Project Reports

N,N′-methylenebisacrylamide-crosslinked poly(N-isopropylacrylamide), also known as P(NIPAM), was developed as a fluid delivery system for use with microfluidic paper-based analytical devices (microPADs). MicroPADs are postage-stamp-sized devices made out of paper that can be used as platforms for low-cost, simple-to-use point-of-care diagnostic assays. P(NIPAM) is a thermally responsive polymer that absorbs aqueous solutions at room temperature and will expel the solutions to microPADs when heated. The fluid delivery characteristics of P(NIPAM) were assessed, and P(NIPAM) was able to deliver multiple solutions to microPADs in specific sequences or simultaneously in a laminar-flow configuration. P(NIPAM) was ...


Characterization Of Corynebacterium Pseudotuberculosis Biovar Equi Isolates Obtained From Cal Poly Horses And Review Of Application Of Transposons To Better Prevent Pigeon Fever In Horses, Irene Hasen 2014 California Polytechnic State University

Characterization Of Corynebacterium Pseudotuberculosis Biovar Equi Isolates Obtained From Cal Poly Horses And Review Of Application Of Transposons To Better Prevent Pigeon Fever In Horses, Irene Hasen

Animal Science

No abstract provided.


Low-Cost Strider For Guatemala, Nicole Catherine Cooper, Gonzalo Hernandez, Jared W. Tower 2014 California Polytechnic State University

Low-Cost Strider For Guatemala, Nicole Catherine Cooper, Gonzalo Hernandez, Jared W. Tower

Mechanical Engineering

The purpose of this project was to create a strider, a type of standing rehabilitation device, for children in developing countries who have trouble walking and supporting their full body weight. The project was initially brought to us by Cal Poly professor Brian Self, who had visited a clinic in San Marcos and determined that there were children there who had difficulties with walking and were a need for a rehabilitation device. The team discussed the problem with Dr. Self, Matt Robinson (a local San Luis Obispo prosthetist), and Cal Poly physics professor Pete Schwartz, all of whom had visited ...


Lessons Learned In Caring For Patients Treated With Therapeutic Hypothermia, Catherine H. Swedberg RN, Kelly A. Wolfenden RN, BSN, CCI 2014 Lehigh Valley Health Network

Lessons Learned In Caring For Patients Treated With Therapeutic Hypothermia, Catherine H. Swedberg Rn, Kelly A. Wolfenden Rn, Bsn, Cci

Patient Care Services / Nursing

No abstract provided.


High-Dose Interleukin-2 Administration In The Oncology Medical-Surgical Setting – An Innovation To Impact Cost Efficiencies, Clinical Outcomes And The Ideal Patient Experience, Deidre L. Kutzler RN, Megan L. Derr RN 2014 Lehigh Valley Health Network

High-Dose Interleukin-2 Administration In The Oncology Medical-Surgical Setting – An Innovation To Impact Cost Efficiencies, Clinical Outcomes And The Ideal Patient Experience, Deidre L. Kutzler Rn, Megan L. Derr Rn

Patient Care Services / Nursing

No abstract provided.


Clinical And Physiological Analysis Of Very Long Apneas In Premature Infants, Anne Mennen 2014 College of William and Mary

Clinical And Physiological Analysis Of Very Long Apneas In Premature Infants, Anne Mennen

Honors Theses

Apnea is common in premature infants, and in severe cases it may impair development. Data recorded during apnea events by hospital monitors at the University of Virginia Neonatal Intensive Care Unit (NICU) include EKG, chest impedance, and pulse oximetry signals. In previous work, an apnea detection algorithm was developed that filtered the cardiac artifact from the chest impedance signal to improve detection of apneas [1]. An unexpected result was the discovery that Very Long Apneas (VLAs) lasting more than 60 seconds are not rare. We use this findings in our research to provide new information about these apneas and to ...


Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham 2014 University of Rhode Island

Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham

Senior Honors Projects

A noted characteristic found in several neurodegenerative disorders, including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and bovine spongiform encephalopathy, is the accumulation of amyloid plaques in the brain. Amyloid plaques contain deposits of fibrillar aggregates of misfolded proteins that disrupt normal functionality in neurons. Certain variants of these misfolded proteins are self-replicating; these self-replicating amyloids are termed prions (for infectious protein). We are interested in how protein misfolding contributes to amyloid formation and how molecular chaperone proteins can change the formation of amyloid deposits. Chaperone proteins function by catalyzing the proper folding of other proteins, the refolding ...


A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard 2014 East Tennessee State University

A Systematic Column Performance Comparison For The Confirmation Of Opioids Used In Pain Management By Lc-Ms, Derek Stallard

Undergraduate Honors Theses

In this study, three different chromatographic column chemistries (C18, Pentafluorophenyl (PFP), Hydrophilic Interaction Chromatography (HILIC)) were compared under optimal conditions to determine which stationary performed best in the separation and detection of a mixture of opioids using LC-MS. Furthermore, these stationary phases were examined in three different column technologies – traditional silica, porous shell, and porous polymer (PRP). The PRP column had the best peak shape for all 13 opioids and dominated for later-eluting compounds. In terms of column reproducibility, the Hamilton C18 column had the lowest %RSD values. The Kinetex HILIC produced the most theoretical plates and best resolution for ...


Bridging Classroom And Lab Teaching In Audiology Using Problem Based Learning, Sriram Boothalingam 2014 Western University

Bridging Classroom And Lab Teaching In Audiology Using Problem Based Learning, Sriram Boothalingam

Teaching Innovation Projects

In traditional classroom settings, disciplinary content is generally presented first and students’ abilities to acquire this knowledge are then assessed through assignments and exams. Problem based learning (PBL), on the other hand, works in reverse: students learn in the context of the problem to be solved (Ram, 1999). PBL is based on both learning theories and constructivist principles.

In Audiology, students’ learning is divided: they study theory in classrooms and the use of sophisticated equipment, and instruments, in lab practicum, separately. In clinical placements, however, student audiologists encounter diverse patients and, consequently, are expected to draw from their theoretical knowledge ...


Eculizumab In The Successful Treatment Of Postpartum Hemolytic Uremic Syndrome - A Case Report, Craig A. Mackaness DO, Frederick S. Fleszler MD 2014 Lehigh Valley Health Network

Eculizumab In The Successful Treatment Of Postpartum Hemolytic Uremic Syndrome - A Case Report, Craig A. Mackaness Do, Frederick S. Fleszler Md

Department of Medicine

No abstract provided.


Determining Knee Loading For Abnormal Gait, Joel D. Hutchison, Dana C. Madsen, Timothy L. Norman, J. D. Blaha MD 2014 Cedarville University

Determining Knee Loading For Abnormal Gait, Joel D. Hutchison, Dana C. Madsen, Timothy L. Norman, J. D. Blaha Md

The Research and Scholarship Symposium

The purpose of this study was to take known experimental loads throughout normal gait and to find the corresponding loading at the knee for both normal gait and abnormal gait. Abnormal gait was defined as a person with varus, i.e. “bowleggedness”, or a person who had an external rotation of the femur (or the inability to internally rotate the femur) which caused an indirect varus in the forward positions of gait. This problem was approached by imposing static equilibrium on the femur. This allowed the loads at the knee to be calculated from the loading at the hip. In ...


Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell 2014 University of Tennessee, Knoxville

Control Of Inflammation In Pancreatic Β-Cells: Role Of Arylpyrazole Compounds, Whitney Lyn Powell

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

The Exhibition of Undergraduate Research and Creative Achievement represents an event in which students involved in undergraduate research can present research projects at the University of Tennessee.


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